CNTFR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.70937264
2locomotory exploration behavior (GO:0035641)5.61033115
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.40561665
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28083879
5pyrimidine nucleobase catabolic process (GO:0006208)5.18344299
6presynaptic membrane assembly (GO:0097105)4.80126307
7sodium ion export (GO:0071436)4.70072127
8presynaptic membrane organization (GO:0097090)4.59490872
9layer formation in cerebral cortex (GO:0021819)4.56436297
10cellular potassium ion homeostasis (GO:0030007)4.51519194
11glutamate secretion (GO:0014047)4.36945987
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.34752510
13synaptic vesicle exocytosis (GO:0016079)4.30497313
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.27318311
15regulation of synaptic vesicle exocytosis (GO:2000300)4.24828818
16neuronal action potential propagation (GO:0019227)4.21400943
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.17171129
18vocalization behavior (GO:0071625)4.14548955
19nucleobase catabolic process (GO:0046113)4.11886821
20gamma-aminobutyric acid transport (GO:0015812)4.03730436
21neurotransmitter secretion (GO:0007269)3.99254262
22cell communication by electrical coupling (GO:0010644)3.95487251
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.94221892
24regulation of glutamate receptor signaling pathway (GO:1900449)3.91121637
25exploration behavior (GO:0035640)3.87443895
26establishment of mitochondrion localization (GO:0051654)3.86085515
27regulation of neuronal synaptic plasticity (GO:0048168)3.78366840
28dendritic spine morphogenesis (GO:0060997)3.74420264
29regulation of synaptic vesicle transport (GO:1902803)3.66241106
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.61985861
31potassium ion import (GO:0010107)3.59268332
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.58472101
33glycine transport (GO:0015816)3.57105053
34negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.56871955
35axon ensheathment in central nervous system (GO:0032291)3.55160529
36central nervous system myelination (GO:0022010)3.55160529
37proline transport (GO:0015824)3.52332164
38neuron cell-cell adhesion (GO:0007158)3.51918637
39regulation of synapse structural plasticity (GO:0051823)3.49137616
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47937001
41neuromuscular process controlling balance (GO:0050885)3.45390242
42activation of protein kinase A activity (GO:0034199)3.45270260
43protein localization to synapse (GO:0035418)3.44887121
44potassium ion homeostasis (GO:0055075)3.42836366
45synaptic transmission, glutamatergic (GO:0035249)3.40398290
46cerebellar Purkinje cell differentiation (GO:0021702)3.37248484
47neuronal ion channel clustering (GO:0045161)3.27979099
48neuromuscular process controlling posture (GO:0050884)3.26656970
49cell migration in hindbrain (GO:0021535)3.25692378
50dendrite morphogenesis (GO:0048813)3.24797595
51regulation of respiratory system process (GO:0044065)3.24571136
52glutamate receptor signaling pathway (GO:0007215)3.22397955
53cerebellar granule cell differentiation (GO:0021707)3.20805543
54neurotransmitter-gated ion channel clustering (GO:0072578)3.20257960
55long-term memory (GO:0007616)3.20097901
56neuromuscular synaptic transmission (GO:0007274)3.19770341
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18706488
58establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.18373936
59mitochondrion transport along microtubule (GO:0047497)3.18373936
60central nervous system projection neuron axonogenesis (GO:0021952)3.18326027
61mechanosensory behavior (GO:0007638)3.17139834
62cellular sodium ion homeostasis (GO:0006883)3.17002432
63cerebellar Purkinje cell layer development (GO:0021680)3.15094052
64cerebral cortex radially oriented cell migration (GO:0021799)3.15092108
65L-amino acid import (GO:0043092)3.14958127
66innervation (GO:0060384)3.13834005
67alanine transport (GO:0032328)3.13810804
68positive regulation of synapse assembly (GO:0051965)3.13697300
69membrane repolarization (GO:0086009)3.12205580
70neurotransmitter transport (GO:0006836)3.11855716
71auditory behavior (GO:0031223)3.10750935
72response to auditory stimulus (GO:0010996)3.09036704
73positive regulation of synapse maturation (GO:0090129)3.06237304
74axonal fasciculation (GO:0007413)3.02007996
75positive regulation of dendritic spine development (GO:0060999)3.01311870
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00823010
77neuron-neuron synaptic transmission (GO:0007270)2.99100872
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98814786
79positive regulation of synaptic transmission, GABAergic (GO:0032230)2.97892316
80regulation of neurotransmitter levels (GO:0001505)2.96987332
81transmission of nerve impulse (GO:0019226)2.94722877
82response to pheromone (GO:0019236)2.93232276
83regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93156618
84positive regulation of potassium ion transmembrane transport (GO:1901381)2.91315458
85neuron recognition (GO:0008038)2.90445522
86establishment of nucleus localization (GO:0040023)2.90287982
87regulation of synaptic plasticity (GO:0048167)2.90076584
88prepulse inhibition (GO:0060134)2.89918232
89synapse assembly (GO:0007416)2.89480215
90positive regulation of membrane potential (GO:0045838)2.89452071
91synaptic vesicle endocytosis (GO:0048488)2.89275892
92cytoskeletal anchoring at plasma membrane (GO:0007016)2.89141697
93axon extension (GO:0048675)2.87568463
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86273981
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83924502
96membrane depolarization during action potential (GO:0086010)2.81871794
97regulation of excitatory postsynaptic membrane potential (GO:0060079)2.81361163
98regulation of neurotransmitter secretion (GO:0046928)2.79208666
99regulation of ARF protein signal transduction (GO:0032012)2.78525108
100regulation of respiratory gaseous exchange (GO:0043576)2.77957480
101amino acid import (GO:0043090)2.77887122
102chemosensory behavior (GO:0007635)2.76779840
103dendritic spine organization (GO:0097061)2.74372777
104regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.74170246
105regulation of dendritic spine morphogenesis (GO:0061001)2.74164344
106cell differentiation in hindbrain (GO:0021533)2.74025641
107neuromuscular process (GO:0050905)2.73257337
108G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72805777
109positive regulation of potassium ion transport (GO:0043268)2.72690589
110synapse organization (GO:0050808)2.72594975
111postsynaptic membrane organization (GO:0001941)2.72032464
112spinal cord development (GO:0021510)2.71972205
113regulation of calcium ion-dependent exocytosis (GO:0017158)2.71475272
114regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.71336601
115membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.71026247
116regulation of postsynaptic membrane potential (GO:0060078)2.70594063
117negative regulation of synaptic transmission, GABAergic (GO:0032229)2.68086815
118regulation of synaptic transmission, glutamatergic (GO:0051966)2.67092282
119cell communication involved in cardiac conduction (GO:0086065)2.65610175
120regulation of neurotransmitter transport (GO:0051588)2.64315771
121camera-type eye morphogenesis (GO:0048593)2.64161065
122positive regulation of dendritic spine morphogenesis (GO:0061003)2.63727548
123regulation of vesicle fusion (GO:0031338)2.63170474
124adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.62918112
125membrane hyperpolarization (GO:0060081)2.58499591
126negative regulation of catenin import into nucleus (GO:0035414)2.56680835
127neuron projection extension involved in neuron projection guidance (GO:1902284)2.56510382
128axon extension involved in axon guidance (GO:0048846)2.56510382
129negative regulation of axonogenesis (GO:0050771)2.54095359
130regulation of synapse maturation (GO:0090128)2.53904774
131peripheral nervous system axon ensheathment (GO:0032292)2.53891439
132myelination in peripheral nervous system (GO:0022011)2.53891439
133neuronal stem cell maintenance (GO:0097150)2.53151303
134membrane assembly (GO:0071709)2.52653433
135positive regulation of dendrite development (GO:1900006)2.51595368
136regulation of dendrite morphogenesis (GO:0048814)2.49506188
137apical protein localization (GO:0045176)2.49366307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.92811195
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03428794
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91895961
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91664104
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91664104
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89968544
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.85910343
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.79077450
9DROSHA_22980978_ChIP-Seq_HELA_Human2.65460176
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.59953995
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.58791395
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57735587
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54037473
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53195439
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50400904
16REST_21632747_ChIP-Seq_MESCs_Mouse2.50125134
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.43395330
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.41939692
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40412518
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38754106
21* EED_16625203_ChIP-ChIP_MESCs_Mouse2.37485454
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.23718334
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19333202
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.15729666
25* ERG_21242973_ChIP-ChIP_JURKAT_Human2.09934633
26ZFP281_18757296_ChIP-ChIP_E14_Mouse2.02547706
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00604463
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94631570
29KDM2B_26808549_Chip-Seq_K562_Human1.83599218
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82646490
31GBX2_23144817_ChIP-Seq_PC3_Human1.82289711
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76869561
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.70850355
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68682779
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68179503
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.67518520
37RNF2_27304074_Chip-Seq_NSC_Mouse1.64409346
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56780862
39AR_21572438_ChIP-Seq_LNCaP_Human1.56757067
40* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53686655
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53098679
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52593451
43* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44932963
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43566874
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.43329625
46RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40348331
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39148910
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35536438
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.34189753
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32360403
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30106281
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29984502
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.28897194
54* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27900904
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26851240
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26452077
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25025828
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22618852
59* AR_19668381_ChIP-Seq_PC3_Human1.21729304
60ZNF274_21170338_ChIP-Seq_K562_Hela1.21497904
61CTCF_27219007_Chip-Seq_Bcells_Human1.20549659
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18886147
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17656019
64* LXR_22292898_ChIP-Seq_THP-1_Human1.16396391
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16154832
66TET1_21490601_ChIP-Seq_MESCs_Mouse1.13875891
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11334680
68IGF1R_20145208_ChIP-Seq_DFB_Human1.07968934
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.07947815
70* KDM2B_26808549_Chip-Seq_JURKAT_Human1.05404322
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05292664
72KDM2B_26808549_Chip-Seq_DND41_Human1.03413913
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03116141
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01838464
75* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00111910
76CBX2_27304074_Chip-Seq_ESCs_Mouse0.99072226
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98981045
78SMAD4_21799915_ChIP-Seq_A2780_Human0.95989276
79* SMAD3_21741376_ChIP-Seq_ESCs_Human0.95152040
80TRIM28_21343339_ChIP-Seq_HEK293_Human0.94038647
81CREB1_26743006_Chip-Seq_LNCaP_Human0.93973610
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93319221
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93259384
84ESR2_21235772_ChIP-Seq_MCF-7_Human0.92820196
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92475859
86RXR_22108803_ChIP-Seq_LS180_Human0.92120553
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91133661
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91133661
89SMC4_20622854_ChIP-Seq_HELA_Human0.90780974
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90703203
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90620325
92SMAD4_21741376_ChIP-Seq_HESCs_Human0.90305088
93KLF4_19829295_ChIP-Seq_ESCs_Human0.90181207
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90037212
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89031555
96ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88411270
97ISL1_27105846_Chip-Seq_CPCs_Mouse0.88237207
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86885060
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86664598
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85045710
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84076449
102SOX3_22085726_ChIP-Seq_NPCs_Mouse0.83864246
103RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83795215
104SOX9_26525672_Chip-Seq_HEART_Mouse0.83460493
105AHR_22903824_ChIP-Seq_MCF-7_Human0.83385467
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83137144
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82945444
108* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82732334
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.82332320
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82195369
111TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81982935
112MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.80629811
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80613581
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80236686
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80158565
116STAT3_23295773_ChIP-Seq_U87_Human0.79928084
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79540484
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79396605
119* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.79353976
120CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78994891
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78693062
122* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77842741
123SMAD3_21741376_ChIP-Seq_EPCs_Human0.77838583
124P53_22127205_ChIP-Seq_FIBROBLAST_Human0.77502481
125CTBP1_25329375_ChIP-Seq_LNCAP_Human0.77184249
126* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77036345
127SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.76712258
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76381975
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.75739551
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75450248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.54859869
2MP0003635_abnormal_synaptic_transmissio3.57018372
3MP0004270_analgesia3.42204755
4MP0004858_abnormal_nervous_system2.90040951
5MP0003880_abnormal_central_pattern2.88690674
6MP0002063_abnormal_learning/memory/cond2.65625533
7MP0009046_muscle_twitch2.59845154
8MP0009745_abnormal_behavioral_response2.59218639
9MP0002064_seizures2.54387930
10MP0003283_abnormal_digestive_organ2.50306857
11MP0005423_abnormal_somatic_nervous2.47011590
12MP0009780_abnormal_chondrocyte_physiolo2.35971250
13MP0002909_abnormal_adrenal_gland2.27284913
14MP0002734_abnormal_mechanical_nocicepti2.21955446
15MP0002572_abnormal_emotion/affect_behav2.19402494
16MP0001486_abnormal_startle_reflex2.11258006
17MP0002272_abnormal_nervous_system2.10827058
18MP0008569_lethality_at_weaning2.07753475
19MP0004885_abnormal_endolymph2.04608357
20MP0001968_abnormal_touch/_nociception1.98168622
21MP0003329_amyloid_beta_deposits1.94541604
22MP0000778_abnormal_nervous_system1.84802776
23MP0002733_abnormal_thermal_nociception1.82303488
24MP0003136_yellow_coat_color1.79958556
25* MP0000955_abnormal_spinal_cord1.76613638
26MP0002822_catalepsy1.71808621
27MP0003122_maternal_imprinting1.71521889
28MP0000566_synostosis1.69662025
29MP0002184_abnormal_innervation1.68412292
30MP0004145_abnormal_muscle_electrophysio1.63538362
31MP0001440_abnormal_grooming_behavior1.63223296
32MP0002653_abnormal_ependyma_morphology1.63020196
33MP0001529_abnormal_vocalization1.62912186
34MP0004811_abnormal_neuron_physiology1.61916008
35MP0002067_abnormal_sensory_capabilities1.60908464
36MP0001501_abnormal_sleep_pattern1.59226994
37MP0001970_abnormal_pain_threshold1.57947915
38MP0002557_abnormal_social/conspecific_i1.55267226
39MP0005646_abnormal_pituitary_gland1.51366969
40MP0002249_abnormal_larynx_morphology1.50588430
41MP0008961_abnormal_basal_metabolism1.42666585
42* MP0002882_abnormal_neuron_morphology1.42285251
43MP0003121_genomic_imprinting1.38094888
44MP0002735_abnormal_chemical_nociception1.37743788
45MP0000049_abnormal_middle_ear1.36416611
46MP0002736_abnormal_nociception_after1.35087550
47MP0001502_abnormal_circadian_rhythm1.32868108
48MP0004233_abnormal_muscle_weight1.32411707
49MP0006292_abnormal_olfactory_placode1.30973554
50MP0002066_abnormal_motor_capabilities/c1.28984647
51MP0001299_abnormal_eye_distance/1.28079066
52MP0005386_behavior/neurological_phenoty1.23727089
53MP0004924_abnormal_behavior1.23727089
54MP0000751_myopathy1.23304136
55MP0004130_abnormal_muscle_cell1.22964344
56MP0003787_abnormal_imprinting1.21483761
57* MP0002152_abnormal_brain_morphology1.21073311
58MP0003633_abnormal_nervous_system1.20691820
59MP0005645_abnormal_hypothalamus_physiol1.20275763
60MP0003938_abnormal_ear_development1.19470025
61MP0002234_abnormal_pharynx_morphology1.18315970
62MP0003690_abnormal_glial_cell1.16112030
63MP0000026_abnormal_inner_ear1.14652913
64MP0000013_abnormal_adipose_tissue1.14202088
65MP0003634_abnormal_glial_cell1.13642355
66MP0000579_abnormal_nail_morphology1.13464372
67MP0004043_abnormal_pH_regulation1.10271474
68MP0000534_abnormal_ureter_morphology1.08672521
69MP0005623_abnormal_meninges_morphology1.06857507
70MP0003631_nervous_system_phenotype1.06434290
71MP0005248_abnormal_Harderian_gland1.05069245
72MP0003011_delayed_dark_adaptation1.04921425
73MP0003632_abnormal_nervous_system1.04059373
74MP0003385_abnormal_body_wall1.03659352
75MP0004142_abnormal_muscle_tone1.03609435
76MP0001984_abnormal_olfaction1.01002854
77MP0008789_abnormal_olfactory_epithelium1.00984258
78MP0005670_abnormal_white_adipose1.00567650
79MP0001905_abnormal_dopamine_level1.00081432
80MP0001963_abnormal_hearing_physiology0.96784191
81MP0000631_abnormal_neuroendocrine_gland0.95957889
82MP0001346_abnormal_lacrimal_gland0.95433763
83MP0002638_abnormal_pupillary_reflex0.95085969
84MP0006072_abnormal_retinal_apoptosis0.91285321
85MP0003942_abnormal_urinary_system0.89320915
86MP0010030_abnormal_orbit_morphology0.88864526
87MP0003123_paternal_imprinting0.88510717
88MP0003879_abnormal_hair_cell0.87761275
89MP0005187_abnormal_penis_morphology0.87459031
90MP0005394_taste/olfaction_phenotype0.87145972
91MP0005499_abnormal_olfactory_system0.87145972
92* MP0002069_abnormal_eating/drinking_beha0.86414844
93MP0003861_abnormal_nervous_system0.85709186
94MP0005167_abnormal_blood-brain_barrier0.85514458
95MP0000537_abnormal_urethra_morphology0.83276429
96MP0003075_altered_response_to0.82918062
97MP0002229_neurodegeneration0.81308986
98MP0001188_hyperpigmentation0.81284121
99MP0006276_abnormal_autonomic_nervous0.80598369
100MP0004133_heterotaxia0.80584645
101* MP0002081_perinatal_lethality0.79744934
102MP0000920_abnormal_myelination0.79538625
103MP0000747_muscle_weakness0.79498871
104MP0002089_abnormal_postnatal_growth/wei0.79260794
105MP0001293_anophthalmia0.79254849
106MP0002233_abnormal_nose_morphology0.79212794
107MP0002752_abnormal_somatic_nervous0.77675730
108MP0003137_abnormal_impulse_conducting0.76681277
109MP0001177_atelectasis0.75677544
110MP0000003_abnormal_adipose_tissue0.74781683
111MP0002116_abnormal_craniofacial_bone0.73951436
112MP0005551_abnormal_eye_electrophysiolog0.73738508
113MP0003705_abnormal_hypodermis_morpholog0.73600073
114MP0000678_abnormal_parathyroid_gland0.73197788
115MP0002751_abnormal_autonomic_nervous0.73133566
116MP0002090_abnormal_vision0.72944917
117MP0010234_abnormal_vibrissa_follicle0.72221067
118MP0004085_abnormal_heartbeat0.71962939
119MP0002697_abnormal_eye_size0.71727342
120MP0000462_abnormal_digestive_system0.68772193
121MP0000428_abnormal_craniofacial_morphol0.68255951
122MP0001485_abnormal_pinna_reflex0.67683149
123MP0003119_abnormal_digestive_system0.67585549
124MP0004742_abnormal_vestibular_system0.66452862
125MP0001943_abnormal_respiration0.65002843
126MP0000604_amyloidosis0.63453026
127MP0010769_abnormal_survival0.61592932

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.05125923
2Focal motor seizures (HP:0011153)4.50180005
3Visual hallucinations (HP:0002367)4.09434183
4Action tremor (HP:0002345)3.96140084
5Focal seizures (HP:0007359)3.86154354
6Megalencephaly (HP:0001355)3.79792335
7Progressive cerebellar ataxia (HP:0002073)3.37135579
8Supranuclear gaze palsy (HP:0000605)3.33771646
9Polyphagia (HP:0002591)3.16178758
10Insomnia (HP:0100785)3.04558431
11Epileptic encephalopathy (HP:0200134)3.00546298
12Depression (HP:0000716)2.94117176
13Ankle clonus (HP:0011448)2.83606040
14Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.82082141
15Abnormality of the 4th metacarpal (HP:0010012)2.78819047
16Atonic seizures (HP:0010819)2.77776341
17Neoplasm of the heart (HP:0100544)2.74421140
18Hemiplegia (HP:0002301)2.67618400
19Dysdiadochokinesis (HP:0002075)2.66197640
20Absence seizures (HP:0002121)2.65035213
21Septo-optic dysplasia (HP:0100842)2.64942810
22Generalized tonic-clonic seizures (HP:0002069)2.64625069
23Hemiparesis (HP:0001269)2.64231126
24Genetic anticipation (HP:0003743)2.60595288
25Limb dystonia (HP:0002451)2.56669837
26Neurofibrillary tangles (HP:0002185)2.52281400
27Abnormality of the lower motor neuron (HP:0002366)2.52223696
28Hyperacusis (HP:0010780)2.51577836
29Cerebral inclusion bodies (HP:0100314)2.45105968
30Abnormality of the aortic arch (HP:0012303)2.45098001
31Postural instability (HP:0002172)2.43229216
32Aplasia involving bones of the upper limbs (HP:0009823)2.42743939
33Aplasia of the phalanges of the hand (HP:0009802)2.42743939
34Aplasia involving bones of the extremities (HP:0009825)2.42743939
35Pointed chin (HP:0000307)2.42579869
36Sleep apnea (HP:0010535)2.41809105
37Intention tremor (HP:0002080)2.37812659
38Ankyloglossia (HP:0010296)2.35754686
39Ventricular fibrillation (HP:0001663)2.34148005
40Overriding aorta (HP:0002623)2.30387767
41Anxiety (HP:0000739)2.29721624
42Pheochromocytoma (HP:0002666)2.28790523
43Dialeptic seizures (HP:0011146)2.28452249
44Turricephaly (HP:0000262)2.28226181
45Coronal craniosynostosis (HP:0004440)2.28050504
46Truncal ataxia (HP:0002078)2.27534225
47Split foot (HP:0001839)2.27209275
48Febrile seizures (HP:0002373)2.26965700
49Elfin facies (HP:0004428)2.26701798
50Poor eye contact (HP:0000817)2.26422043
51Abnormal eating behavior (HP:0100738)2.25889116
52Impaired vibration sensation in the lower limbs (HP:0002166)2.25089992
53Diplopia (HP:0000651)2.22639659
54Abnormality of binocular vision (HP:0011514)2.22639659
55Trigonocephaly (HP:0000243)2.22391474
56Dysmetria (HP:0001310)2.22306438
57Renal duplication (HP:0000075)2.21577566
58Annular pancreas (HP:0001734)2.21026025
59Cutaneous finger syndactyly (HP:0010554)2.20027467
60Bronchomalacia (HP:0002780)2.19698742
61Drooling (HP:0002307)2.18929839
62Hypercortisolism (HP:0001578)2.18677384
63Abnormal social behavior (HP:0012433)2.18553597
64Impaired social interactions (HP:0000735)2.18553597
65Torticollis (HP:0000473)2.18547833
66Calcaneovalgus deformity (HP:0001848)2.17715188
67Papilledema (HP:0001085)2.16131516
68Urinary bladder sphincter dysfunction (HP:0002839)2.15919158
69Impaired smooth pursuit (HP:0007772)2.12586915
70Agitation (HP:0000713)2.11150896
71Vitreoretinal degeneration (HP:0000655)2.09832110
72Amblyopia (HP:0000646)2.08112747
73Cutaneous syndactyly (HP:0012725)2.07698320
74Oligodactyly (HP:0012165)2.06813859
75Gaze-evoked nystagmus (HP:0000640)2.06516642
76Cortical dysplasia (HP:0002539)2.05255506
77Rib fusion (HP:0000902)2.04146078
78Postural tremor (HP:0002174)2.02862000
79Gait imbalance (HP:0002141)2.02730875
80Renovascular hypertension (HP:0100817)2.02642841
81Hypoventilation (HP:0002791)2.01730006
82Abnormality of the corticospinal tract (HP:0002492)2.01535696
83Urinary urgency (HP:0000012)1.99543031
84Oligodactyly (hands) (HP:0001180)1.95132242
85Excessive salivation (HP:0003781)1.94672978
86Macroorchidism (HP:0000053)1.93836069
87Spastic gait (HP:0002064)1.93667569
88Hypsarrhythmia (HP:0002521)1.92709903
89Ulnar claw (HP:0001178)1.92704585
90Short 4th metacarpal (HP:0010044)1.92222588
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92222588
92Focal dystonia (HP:0004373)1.92108620
93EEG with generalized epileptiform discharges (HP:0011198)1.91453709
94Deformed tarsal bones (HP:0008119)1.91049342
95Broad-based gait (HP:0002136)1.90414142
96Dysmetric saccades (HP:0000641)1.89499762
97Shallow orbits (HP:0000586)1.88854193
98Partial duplication of the phalanx of hand (HP:0009999)1.88753181
99Abnormality of ocular smooth pursuit (HP:0000617)1.88325324
100Abnormality of the ischium (HP:0003174)1.88086908
101Hypoplasia of the brainstem (HP:0002365)1.87261489
102Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87261489
103Myotonia (HP:0002486)1.87046951
104Enlarged penis (HP:0000040)1.86349691
105Epileptiform EEG discharges (HP:0011182)1.86148445
106Anophthalmia (HP:0000528)1.85319047
107Bundle branch block (HP:0011710)1.84924871
108Obstructive sleep apnea (HP:0002870)1.84101765
109Fetal akinesia sequence (HP:0001989)1.83407598
110Hypoplasia of the corpus callosum (HP:0002079)1.82916190
111Hepatoblastoma (HP:0002884)1.82847890
112Partial duplication of thumb phalanx (HP:0009944)1.81790926
113Specific learning disability (HP:0001328)1.81254391
114Termporal pattern (HP:0011008)1.81097190
115Insidious onset (HP:0003587)1.81097190
116Bradykinesia (HP:0002067)1.78234703
117Humeroradial synostosis (HP:0003041)1.78113136
118Synostosis involving the elbow (HP:0003938)1.78113136
119Stereotypic behavior (HP:0000733)1.77909549
120Difficulty running (HP:0009046)1.77692186
121Scanning speech (HP:0002168)1.77101053
122Neuroendocrine neoplasm (HP:0100634)1.76989766
123Absent septum pellucidum (HP:0001331)1.76942555
124Optic nerve hypoplasia (HP:0000609)1.76755367
125Abnormality of the labia minora (HP:0012880)1.76726970
126Abnormality of the diencephalon (HP:0010662)1.75696804
127Abnormality of calcium-phosphate metabolism (HP:0100530)1.75519514
128Craniofacial dystonia (HP:0012179)1.73027131
129High anterior hairline (HP:0009890)1.71015195
130Bowel diverticulosis (HP:0005222)1.69630224
131Lower limb muscle weakness (HP:0007340)1.69394872
132Flat cornea (HP:0007720)1.68585936
133Aqueductal stenosis (HP:0002410)1.68498294
134Status epilepticus (HP:0002133)1.67933306
135Neoplasm of the peripheral nervous system (HP:0100007)1.67551741
136Pachygyria (HP:0001302)1.66549196
137Exercise-induced myalgia (HP:0003738)1.65721555
138Peripheral hypomyelination (HP:0007182)1.63489828
139Clonus (HP:0002169)1.63410520
140Failure to thrive in infancy (HP:0001531)1.63112604
141Mutism (HP:0002300)1.62868133
142Akinesia (HP:0002304)1.61089746
143Retinal dysplasia (HP:0007973)1.60006556
144Exotropia (HP:0000577)1.59429978
145Midline defect of the nose (HP:0004122)1.59012300
146Morphological abnormality of the pyramidal tract (HP:0002062)1.58210271
147Tracheomalacia (HP:0002779)1.58071897
148Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.57808107
149Renal hypoplasia (HP:0000089)1.56947273
150Shawl scrotum (HP:0000049)1.56820038
151Hypoplastic ischia (HP:0003175)1.56307327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.74485344
2MAP3K93.60079681
3EPHA43.43961909
4PRKD33.36061455
5CASK3.08920421
6NTRK22.45308421
7NTRK12.42162099
8MARK12.41277192
9PAK62.39630953
10MINK12.32996502
11KSR22.25032896
12MAP3K42.09545706
13DAPK22.02669905
14DYRK22.00471081
15TRIB31.93498186
16PHKG21.90059809
17PHKG11.90059809
18CAMKK11.87268789
19LMTK21.68664693
20KSR11.63086663
21UHMK11.61257016
22RIPK11.60489634
23TYRO31.59345326
24MAP3K21.45556359
25STK381.43886074
26MAPK151.42128551
27CDK51.39313230
28EPHA31.38695060
29MAP2K41.31836157
30TAOK11.30784293
31ICK1.27408447
32ALK1.26603136
33LATS21.25377427
34BCR1.21962141
35RET1.19524925
36PRKCH1.15500148
37PDGFRA1.13658853
38PNCK1.11364200
39MAP2K71.10614754
40CDK191.08946235
41DYRK1B1.08945097
42CAMK1G1.08072114
43SIK11.04235911
44SGK2231.03735704
45SGK4941.03735704
46SIK21.03567155
47PRPF4B1.00853325
48PRKCG0.99233090
49OBSCN0.98121344
50WNK10.96429854
51FGFR20.96034503
52PKN10.95263380
53NEK10.93797462
54CAMK1D0.92249322
55CDK150.90485019
56STK110.89836592
57SGK30.89585843
58CDK180.89391627
59CAMKK20.87625757
60EPHB20.87036661
61CDK140.86627340
62CDC42BPA0.86240779
63PAK30.85268219
64GRK50.85114726
65MAPK130.82630380
66MAP3K10.80535175
67TNIK0.80094127
68CDK11A0.79470366
69SGK20.77612381
70PINK10.77525226
71DDR20.77070609
72CAMK10.77066786
73MAP3K100.76128412
74DAPK10.75257584
75MARK20.75014103
76PTK20.72620298
77SCYL20.70222900
78INSRR0.68929381
79PLK20.68408999
80LIMK10.67948828
81BMX0.67891050
82ERBB20.64642648
83ARAF0.62726915
84HIPK20.60566416
85CAMK2A0.58951743
86CAMK40.56835918
87SGK10.56547738
88FER0.55885840
89FGFR10.55320209
90CSNK1G30.54993722
91RPS6KA30.54970482
92DMPK0.52755954
93MAP3K70.51593411
94PKN20.51094992
95MAPK100.50768878
96DYRK1A0.50680994
97PDPK10.50415954
98PTK60.49421474
99PRKAA10.49272745
100CSNK1A1L0.49160030
101PRKCZ0.48761963
102CSNK1G20.48252455
103MOS0.47943080
104PRKD20.46915205
105BRSK10.46676113
106TESK10.45607624
107ROCK20.43029039
108CAMK2B0.42879330
109CSNK1G10.41782737
110RPS6KA20.41022715
111CAMK2D0.40866735
112MAPK120.40004488
113PRKD10.39384534
114CSNK1E0.39239943
115CAMK2G0.39218677
116ROCK10.38863448
117PDK10.38779249
118BRAF0.38150999
119FYN0.37620497
120MKNK20.37005758
121WNK40.36863943
122RIPK40.36719948
123MAPK40.34559059
124PRKACA0.33945026
125PRKG10.33659375
126DYRK30.33605462
127MKNK10.33425003
128CDK30.32959039
129MAPK90.32902517

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.71487374
2Synaptic vesicle cycle_Homo sapiens_hsa047212.63267290
3Nicotine addiction_Homo sapiens_hsa050332.61233820
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.43555531
5GABAergic synapse_Homo sapiens_hsa047272.35057553
6Insulin secretion_Homo sapiens_hsa049112.33297992
7Circadian entrainment_Homo sapiens_hsa047132.31320400
8Glutamatergic synapse_Homo sapiens_hsa047242.23704059
9Long-term potentiation_Homo sapiens_hsa047202.20439187
10Olfactory transduction_Homo sapiens_hsa047402.03986666
11Amphetamine addiction_Homo sapiens_hsa050311.97917685
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95757689
13Morphine addiction_Homo sapiens_hsa050321.94279786
14Salivary secretion_Homo sapiens_hsa049701.90939827
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88793543
16Gastric acid secretion_Homo sapiens_hsa049711.82941205
17Dopaminergic synapse_Homo sapiens_hsa047281.77887953
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74444489
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74285512
20Cocaine addiction_Homo sapiens_hsa050301.71473040
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69102607
22Cholinergic synapse_Homo sapiens_hsa047251.64003089
23Type II diabetes mellitus_Homo sapiens_hsa049301.60352686
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53758803
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48774980
26Long-term depression_Homo sapiens_hsa047301.48737744
27Taste transduction_Homo sapiens_hsa047421.42877962
28Melanogenesis_Homo sapiens_hsa049161.36160574
29Oxytocin signaling pathway_Homo sapiens_hsa049211.34720707
30Gap junction_Homo sapiens_hsa045401.33780214
31Renin secretion_Homo sapiens_hsa049241.32155978
32GnRH signaling pathway_Homo sapiens_hsa049121.29283240
33Estrogen signaling pathway_Homo sapiens_hsa049151.29254163
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24331219
35Dorso-ventral axis formation_Homo sapiens_hsa043201.23187763
36Notch signaling pathway_Homo sapiens_hsa043301.21847826
37Calcium signaling pathway_Homo sapiens_hsa040201.19939447
38cAMP signaling pathway_Homo sapiens_hsa040241.19711188
39Axon guidance_Homo sapiens_hsa043601.17648405
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17218421
41Hedgehog signaling pathway_Homo sapiens_hsa043401.15920384
42Glioma_Homo sapiens_hsa052141.14869270
43Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12601162
44Serotonergic synapse_Homo sapiens_hsa047261.10293628
45Pancreatic secretion_Homo sapiens_hsa049721.05996612
46Basal cell carcinoma_Homo sapiens_hsa052171.02252242
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99738278
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99692627
49Thyroid hormone synthesis_Homo sapiens_hsa049180.97416408
50ErbB signaling pathway_Homo sapiens_hsa040120.96361589
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92444413
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92425625
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.92017005
54Bile secretion_Homo sapiens_hsa049760.90855116
55Phototransduction_Homo sapiens_hsa047440.90817780
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89549287
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86627750
58Dilated cardiomyopathy_Homo sapiens_hsa054140.85934409
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.84313754
60Fatty acid biosynthesis_Homo sapiens_hsa000610.84006235
61Glucagon signaling pathway_Homo sapiens_hsa049220.83992462
62Oocyte meiosis_Homo sapiens_hsa041140.81931830
63mTOR signaling pathway_Homo sapiens_hsa041500.80670985
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78961360
65Cardiac muscle contraction_Homo sapiens_hsa042600.76965273
66Arginine and proline metabolism_Homo sapiens_hsa003300.76756188
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.76190425
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76068561
69Fatty acid metabolism_Homo sapiens_hsa012120.75459787
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75091598
71Endometrial cancer_Homo sapiens_hsa052130.73782289
72Wnt signaling pathway_Homo sapiens_hsa043100.72578597
73Butanoate metabolism_Homo sapiens_hsa006500.72521267
74Insulin signaling pathway_Homo sapiens_hsa049100.72087342
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68732141
76Vibrio cholerae infection_Homo sapiens_hsa051100.68524101
77PPAR signaling pathway_Homo sapiens_hsa033200.68235224
78Hippo signaling pathway_Homo sapiens_hsa043900.67996338
79Steroid biosynthesis_Homo sapiens_hsa001000.67765291
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.67685480
81MAPK signaling pathway_Homo sapiens_hsa040100.66056664
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.65035040
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64790843
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64775446
85Sulfur relay system_Homo sapiens_hsa041220.64754019
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64409740
87Renal cell carcinoma_Homo sapiens_hsa052110.64046004
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63662286
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62033737
90VEGF signaling pathway_Homo sapiens_hsa043700.61705136
91Circadian rhythm_Homo sapiens_hsa047100.61643049
92Choline metabolism in cancer_Homo sapiens_hsa052310.60548124
93Prion diseases_Homo sapiens_hsa050200.58640684
94Rap1 signaling pathway_Homo sapiens_hsa040150.58592797
95Collecting duct acid secretion_Homo sapiens_hsa049660.57088616
96Non-small cell lung cancer_Homo sapiens_hsa052230.56879766
97Protein digestion and absorption_Homo sapiens_hsa049740.56638580
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54726400
99Endocytosis_Homo sapiens_hsa041440.53866550
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53208811
101Colorectal cancer_Homo sapiens_hsa052100.52742828
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51986670
103Propanoate metabolism_Homo sapiens_hsa006400.51011503
104Alcoholism_Homo sapiens_hsa050340.48603870
105Type I diabetes mellitus_Homo sapiens_hsa049400.48403695
106Ras signaling pathway_Homo sapiens_hsa040140.47831999
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.47453810
108Proteoglycans in cancer_Homo sapiens_hsa052050.46500678
109beta-Alanine metabolism_Homo sapiens_hsa004100.46347988
110Insulin resistance_Homo sapiens_hsa049310.46001008
111Vitamin B6 metabolism_Homo sapiens_hsa007500.44998835
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44489041
113Ovarian steroidogenesis_Homo sapiens_hsa049130.42925346
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41401546
115Tight junction_Homo sapiens_hsa045300.40402283
116AMPK signaling pathway_Homo sapiens_hsa041520.38575449
117Inositol phosphate metabolism_Homo sapiens_hsa005620.37843570
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37351647
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36772305
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.34679344

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