CNTD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)8.34346177
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.59065913
3regulation of female gonad development (GO:2000194)6.41654697
4oocyte development (GO:0048599)6.08020904
5protein kinase C signaling (GO:0070528)6.04070094
6multicellular organism reproduction (GO:0032504)5.99486017
7peptidyl-glutamic acid carboxylation (GO:0017187)5.41565816
8protein carboxylation (GO:0018214)5.41565816
9GDP-mannose metabolic process (GO:0019673)5.09990099
10negative regulation of fatty acid transport (GO:2000192)4.56402827
11negative regulation of reproductive process (GO:2000242)4.28504263
12protein retention in ER lumen (GO:0006621)4.21274360
13positive regulation of humoral immune response (GO:0002922)4.19120901
14reproduction (GO:0000003)4.17998678
15L-phenylalanine metabolic process (GO:0006558)4.10349370
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.10349370
17regulation of phospholipid biosynthetic process (GO:0071071)4.06882790
18regulation of cytokine production involved in inflammatory response (GO:1900015)4.05001046
19proline biosynthetic process (GO:0006561)4.02783098
20regulation of cholesterol homeostasis (GO:2000188)3.88986859
21regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.85171792
22binding of sperm to zona pellucida (GO:0007339)3.81106978
23exocrine pancreas development (GO:0031017)3.80177337
24proline metabolic process (GO:0006560)3.75826438
25regulation of DNA methylation (GO:0044030)3.75619988
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.72155953
27positive regulation of hormone metabolic process (GO:0032352)3.71527433
28regulation of cholesterol esterification (GO:0010872)3.63463651
29amyloid precursor protein catabolic process (GO:0042987)3.61370434
30endothelial cell chemotaxis (GO:0035767)3.60298545
31COPI coating of Golgi vesicle (GO:0048205)3.54859912
32Golgi transport vesicle coating (GO:0048200)3.54859912
33positive regulation of lipoprotein lipase activity (GO:0051006)3.46273871
34positive regulation of triglyceride lipase activity (GO:0061365)3.46273871
35regulation of cholesterol biosynthetic process (GO:0045540)3.45805517
36phosphatidylethanolamine biosynthetic process (GO:0006646)3.36945614
37regulation of fatty acid beta-oxidation (GO:0031998)3.32113996
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.28027207
39L-phenylalanine catabolic process (GO:0006559)3.28027207
40citrulline biosynthetic process (GO:0019240)3.27352312
41regulation of calcium ion-dependent exocytosis (GO:0017158)3.25900171
42negative regulation of cell size (GO:0045792)3.19715881
43regulation of bile acid biosynthetic process (GO:0070857)3.19343202
44positive regulation of cellular amine metabolic process (GO:0033240)3.16365263
45cell-cell junction maintenance (GO:0045217)3.15517220
46regulation of chromatin binding (GO:0035561)3.13761195
47urea cycle (GO:0000050)3.08513443
48sperm-egg recognition (GO:0035036)3.05146282
49phosphatidylethanolamine metabolic process (GO:0046337)2.98978483
50response to misfolded protein (GO:0051788)2.96563418
51regulation of fibrinolysis (GO:0051917)2.96538636
52biotin metabolic process (GO:0006768)2.94480764
53urea metabolic process (GO:0019627)2.92334021
54plasma lipoprotein particle assembly (GO:0034377)2.91628976
55DNA methylation involved in gamete generation (GO:0043046)2.91338630
56negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.88995977
57peptidyl-tyrosine autophosphorylation (GO:0038083)2.86061017
58regulation of plasminogen activation (GO:0010755)2.84119344
59negative regulation of fibrinolysis (GO:0051918)2.83651861
60regulation of cholesterol metabolic process (GO:0090181)2.82225883
61virion assembly (GO:0019068)2.82172823
62peptidyl-glutamic acid modification (GO:0018200)2.76176659
63negative regulation of lipase activity (GO:0060192)2.75341239
64single fertilization (GO:0007338)2.75155263
65positive regulation of hormone biosynthetic process (GO:0046886)2.74373899
66positive regulation of reproductive process (GO:2000243)2.74068939
67negative regulation of histone methylation (GO:0031061)2.72978260
68viral protein processing (GO:0019082)2.69500431
69positive regulation of steroid metabolic process (GO:0045940)2.68112853
70mitotic chromosome condensation (GO:0007076)2.67626268
71intestinal epithelial cell development (GO:0060576)2.67613836
72positive regulation of fatty acid beta-oxidation (GO:0032000)2.67250001
73cerebral cortex neuron differentiation (GO:0021895)2.65639766
74positive regulation of steroid biosynthetic process (GO:0010893)2.64075363
75retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.64070783
76myelin maintenance (GO:0043217)2.62655420
77mammary gland epithelial cell differentiation (GO:0060644)2.61750514
78nitrogen cycle metabolic process (GO:0071941)2.61150289
79negative regulation of lipid transport (GO:0032369)2.60524810
80amyloid precursor protein metabolic process (GO:0042982)2.59754138
81very-low-density lipoprotein particle assembly (GO:0034379)2.58506594
82phospholipid efflux (GO:0033700)2.56965951
83regulation of steroid hormone biosynthetic process (GO:0090030)2.56038657
84citrulline metabolic process (GO:0000052)2.55126833
85regulation of autophagic vacuole assembly (GO:2000785)2.54463372
86cellular zinc ion homeostasis (GO:0006882)2.53285267
87fertilization (GO:0009566)2.51820900
88meiotic cell cycle (GO:0051321)2.51656855
89activation of Rac GTPase activity (GO:0032863)2.50707767
90regulation of lipoprotein particle clearance (GO:0010984)2.50542029
91protein-lipid complex assembly (GO:0065005)2.50030647
92cell junction maintenance (GO:0034331)2.49597765
93nucleotide-sugar biosynthetic process (GO:0009226)2.47834466
94regulation of reproductive process (GO:2000241)2.47833365
95cholesterol efflux (GO:0033344)2.47799330
96ear development (GO:0043583)2.47352461
97histone H2B ubiquitination (GO:0033523)2.46466067
98phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.46393355
99focal adhesion assembly (GO:0048041)2.46385451
100cell-substrate adherens junction assembly (GO:0007045)2.46385451

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.75833977
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.42888418
3ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.89512627
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.80043253
5* ESR2_21235772_ChIP-Seq_MCF-7_Human2.74711164
6LXR_22292898_ChIP-Seq_THP-1_Human2.74658291
7RACK7_27058665_Chip-Seq_MCF-7_Human2.65275848
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.55551210
9VDR_21846776_ChIP-Seq_THP-1_Human2.29066958
10* P68_20966046_ChIP-Seq_HELA_Human2.24657290
11ZNF263_19887448_ChIP-Seq_K562_Human2.20255482
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.16102231
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13122963
14TET1_21451524_ChIP-Seq_MESCs_Mouse2.09930866
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.01124002
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98307822
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.96385672
18HIF1A_21447827_ChIP-Seq_MCF-7_Human1.94517829
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.89742310
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85719780
21ERG_21242973_ChIP-ChIP_JURKAT_Human1.80595630
22PPARA_22158963_ChIP-Seq_LIVER_Mouse1.79799427
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.77445641
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76954541
25SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.74820765
26* RUNX1_27514584_Chip-Seq_MCF-7_Human1.74086848
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72701586
28SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.72138614
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.70649975
30* SMC4_20622854_ChIP-Seq_HELA_Human1.69848525
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69365034
32BCOR_27268052_Chip-Seq_Bcells_Human1.68300009
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68160724
34TCF7_22412390_ChIP-Seq_EML_Mouse1.67032494
35EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65045586
36KDM2B_26808549_Chip-Seq_DND41_Human1.61997583
37CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.61632072
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.60622511
39SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.56856030
40CREB1_26743006_Chip-Seq_LNCaP_Human1.56697325
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55505436
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53614328
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52997143
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52826895
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48451989
46SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.47558089
47DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.47262926
48BCL6_27268052_Chip-Seq_Bcells_Human1.46645558
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.46266908
50CTCF_27219007_Chip-Seq_Bcells_Human1.45280672
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44408710
52PKCTHETA_26484144_Chip-Seq_BREAST_Human1.40197716
53KDM2B_26808549_Chip-Seq_K562_Human1.40126624
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36465237
55CTCF_21964334_Chip-Seq_Bcells_Human1.36244802
56MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.36195151
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.35945329
58MYC_22102868_ChIP-Seq_BL_Human1.34682045
59E2F1_20622854_ChIP-Seq_HELA_Human1.33900108
60RARB_24833708_ChIP-Seq_LIVER_Mouse1.33500417
61PHF8_20622854_ChIP-Seq_HELA_Human1.32104479
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30940939
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30202188
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28893411
65FOXP1_21924763_ChIP-Seq_HESCs_Human1.28566359
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27022791
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24482278
68CTCF_26484167_Chip-Seq_Bcells_Mouse1.23400659
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23176479
70* ATF3_27146783_Chip-Seq_COLON_Human1.22868872
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18699935
72TP63_22573176_ChIP-Seq_HFKS_Human1.17873339
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17529542
74CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17291820
75CTCF_20526341_ChIP-Seq_ESCs_Human1.17236456
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.16766835
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16678487
78ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16467594
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.15330011
80MAF_26560356_Chip-Seq_TH2_Human1.14282265
81* YY1_22570637_ChIP-Seq_MALME-3M_Human1.13500434
82TP53_22127205_ChIP-Seq_IMR90_Human1.12580619
83XRN2_22483619_ChIP-Seq_HELA_Human1.11580274
84ETS1_21867929_ChIP-Seq_TH2_Mouse1.10808937
85RARA_24833708_ChIP-Seq_LIVER_Mouse1.09965114
86OCT4_19829295_ChIP-Seq_ESCs_Human1.05606116
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05161879
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05150092
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03304803
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03089339
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02061990
92ERA_21632823_ChIP-Seq_H3396_Human1.01946916
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01659701
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00735835
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00276519
96P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.99833377
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99332148
98RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98065470
99KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97715510
100JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97662367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.59194843
2MP0002139_abnormal_hepatobiliary_system3.81600267
3MP0003718_maternal_effect3.80662654
4MP0009840_abnormal_foam_cell3.44484324
5MP0003878_abnormal_ear_physiology3.29431092
6MP0005377_hearing/vestibular/ear_phenot3.29431092
7MP0003136_yellow_coat_color3.03787848
8MP0004264_abnormal_extraembryonic_tissu2.97840548
9MP0003123_paternal_imprinting2.89419116
10MP0010234_abnormal_vibrissa_follicle2.88948485
11MP0005451_abnormal_body_composition2.71734111
12MP0003705_abnormal_hypodermis_morpholog2.67668250
13MP0005365_abnormal_bile_salt2.49619785
14MP0005409_darkened_coat_color2.30749532
15MP0003879_abnormal_hair_cell2.30290829
16MP0000566_synostosis2.25609697
17MP0002089_abnormal_postnatal_growth/wei2.20746980
18MP0005410_abnormal_fertilization1.94170556
19MP0010030_abnormal_orbit_morphology1.93789365
20MP0008875_abnormal_xenobiotic_pharmacok1.90750678
21MP0005257_abnormal_intraocular_pressure1.86357882
22MP0001666_abnormal_nutrient_absorption1.79084345
23MP0005395_other_phenotype1.62879950
24MP0004381_abnormal_hair_follicle1.58943099
25MP0003699_abnormal_female_reproductive1.58033456
26MP0005076_abnormal_cell_differentiation1.57575048
27MP0003191_abnormal_cellular_cholesterol1.54740568
28MP0008260_abnormal_autophagy1.51024827
29MP0002796_impaired_skin_barrier1.47422671
30MP0005085_abnormal_gallbladder_physiolo1.44293331
31MP0005058_abnormal_lysosome_morphology1.34510908
32MP0010329_abnormal_lipoprotein_level1.32968336
33MP0004185_abnormal_adipocyte_glucose1.32339159
34MP0001929_abnormal_gametogenesis1.32070752
35MP0005501_abnormal_skin_physiology1.30661079
36MP0009384_cardiac_valve_regurgitation1.28332579
37MP0002653_abnormal_ependyma_morphology1.28072599
38MP0010678_abnormal_skin_adnexa1.27636736
39MP0002822_catalepsy1.27441798
40MP0000383_abnormal_hair_follicle1.26695707
41MP0001664_abnormal_digestion1.22250764
42MP0002161_abnormal_fertility/fecundity1.21060290
43MP0002249_abnormal_larynx_morphology1.18867859
44MP0000003_abnormal_adipose_tissue1.14924682
45MP0005423_abnormal_somatic_nervous1.13394438
46MP0000678_abnormal_parathyroid_gland1.12015082
47MP0000470_abnormal_stomach_morphology1.09571774
48MP0003693_abnormal_embryo_hatching1.06210047
49MP0001502_abnormal_circadian_rhythm1.04660192
50MP0001764_abnormal_homeostasis1.02460581
51MP0002098_abnormal_vibrissa_morphology1.01034193
52MP0002118_abnormal_lipid_homeostasis1.00556447
53MP0003195_calcinosis0.99872230
54MP0001944_abnormal_pancreas_morphology0.98561782
55MP0009780_abnormal_chondrocyte_physiolo0.98101373
56MP0002210_abnormal_sex_determination0.97915855
57MP0005083_abnormal_biliary_tract0.97816116
58MP0006292_abnormal_olfactory_placode0.97690650
59MP0003453_abnormal_keratinocyte_physiol0.94117285
60MP0002138_abnormal_hepatobiliary_system0.93107952
61MP0005375_adipose_tissue_phenotype0.92855610
62MP0000653_abnormal_sex_gland0.91106486
63MP0005394_taste/olfaction_phenotype0.90492818
64MP0005499_abnormal_olfactory_system0.90492818
65MP0003329_amyloid_beta_deposits0.89557163
66MP0000750_abnormal_muscle_regeneration0.87834039
67MP0005666_abnormal_adipose_tissue0.87726563
68MP0001968_abnormal_touch/_nociception0.86920478
69MP0000762_abnormal_tongue_morphology0.84415629
70MP0004019_abnormal_vitamin_homeostasis0.83816972
71MP0002160_abnormal_reproductive_system0.82882851
72MP0000377_abnormal_hair_follicle0.81423509
73MP0001873_stomach_inflammation0.80624170
74MP0001661_extended_life_span0.79832416
75MP0009672_abnormal_birth_weight0.78978603
76MP0001986_abnormal_taste_sensitivity0.76446046
77MP0003122_maternal_imprinting0.75799709
78MP0010368_abnormal_lymphatic_system0.75274421
79MP0003959_abnormal_lean_body0.75150649
80MP0003183_abnormal_peptide_metabolism0.73735498
81MP0003698_abnormal_male_reproductive0.73531124
82MP0003121_genomic_imprinting0.72713720
83MP0000609_abnormal_liver_physiology0.72503937
84MP0003942_abnormal_urinary_system0.72276230
85MP0008789_abnormal_olfactory_epithelium0.71511912
86MP0005332_abnormal_amino_acid0.71128444
87MP0000538_abnormal_urinary_bladder0.70402287
88MP0010771_integument_phenotype0.69107675
89MP0005220_abnormal_exocrine_pancreas0.68915210
90MP0002970_abnormal_white_adipose0.68654376
91MP0002909_abnormal_adrenal_gland0.68011310
92MP0000026_abnormal_inner_ear0.67742350
93MP0001119_abnormal_female_reproductive0.67129723
94MP0009115_abnormal_fat_cell0.66415913
95MP0001730_embryonic_growth_arrest0.65804872
96MP0000467_abnormal_esophagus_morphology0.65798655
97MP0003868_abnormal_feces_composition0.65733324
98MP0002735_abnormal_chemical_nociception0.63415472
99MP0005646_abnormal_pituitary_gland0.63034433
100MP0000427_abnormal_hair_cycle0.62907441

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.47094303
2Abnormal gallbladder physiology (HP:0012438)5.11957010
3Cholecystitis (HP:0001082)5.11957010
4Prolonged partial thromboplastin time (HP:0003645)4.62432606
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.71962447
6Thin bony cortex (HP:0002753)3.71360738
7Aplasia of the musculature (HP:0100854)3.59101802
8Joint hemorrhage (HP:0005261)3.54063192
9Asymmetry of the thorax (HP:0001555)3.44001412
10Hemorrhage of the eye (HP:0011885)3.42954362
11Flat acetabular roof (HP:0003180)3.35793381
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.28078328
13Menstrual irregularities (HP:0000858)3.08590442
14Hypophosphatemic rickets (HP:0004912)3.08338338
15Facial hemangioma (HP:0000329)2.99150868
16Spinal cord compression (HP:0002176)2.89075139
17Enlarged penis (HP:0000040)2.87285628
18Ulnar claw (HP:0001178)2.83183716
19Testicular atrophy (HP:0000029)2.74486647
20J-shaped sella turcica (HP:0002680)2.72128881
21Growth hormone excess (HP:0000845)2.63909831
22Abnormality of carpal bone ossification (HP:0006257)2.48920526
23Septate vagina (HP:0001153)2.46844056
24Obstructive sleep apnea (HP:0002870)2.44617889
25Biconcave vertebral bodies (HP:0004586)2.41531764
26Delayed CNS myelination (HP:0002188)2.39633398
27Vaginal fistula (HP:0004320)2.37829046
28Long palpebral fissure (HP:0000637)2.37666560
29Intrahepatic cholestasis (HP:0001406)2.35243227
30Upper limb amyotrophy (HP:0009129)2.33087814
31Distal upper limb amyotrophy (HP:0007149)2.33087814
32Partial duplication of thumb phalanx (HP:0009944)2.32803670
33Hand muscle atrophy (HP:0009130)2.32431448
34Impulsivity (HP:0100710)2.30087972
35Broad distal phalanx of finger (HP:0009836)2.28827282
36Concave nail (HP:0001598)2.28708288
37Abnormal tarsal ossification (HP:0008369)2.28529555
38Hypoalphalipoproteinemia (HP:0003233)2.27552822
39Hypercortisolism (HP:0001578)2.21520189
40Cholelithiasis (HP:0001081)2.20671551
41Infertility (HP:0000789)2.18779870
42Progressive sensorineural hearing impairment (HP:0000408)2.17054421
43Abnormality of the Achilles tendon (HP:0005109)2.16995049
44Pterygium (HP:0001059)2.15163566
45Hypercholesterolemia (HP:0003124)2.13637293
46Lip pit (HP:0100267)2.08704778
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07527497
48Lymphangioma (HP:0100764)2.06712246
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06490892
50Stridor (HP:0010307)2.06444733
51Congenital glaucoma (HP:0001087)2.03143243
52Testicular neoplasm (HP:0010788)1.99798948
53Xanthomatosis (HP:0000991)1.96901852
54Osteomalacia (HP:0002749)1.94142391
55Achilles tendon contracture (HP:0001771)1.90570041
56Abnormality of the common coagulation pathway (HP:0010990)1.90449825
57Premature skin wrinkling (HP:0100678)1.89648720
58Ulnar bowing (HP:0003031)1.89094043
59Abnormal ossification of hand bones (HP:0005921)1.88815863
60Abnormality of the intrinsic pathway (HP:0010989)1.88563396
61Cervical subluxation (HP:0003308)1.87986686
62Abnormal urine phosphate concentration (HP:0012599)1.86496545
63Partial duplication of the phalanx of hand (HP:0009999)1.86462421
64Acanthosis nigricans (HP:0000956)1.85851840
65Vertebral compression fractures (HP:0002953)1.85529385
66Myokymia (HP:0002411)1.82758760
67Back pain (HP:0003418)1.82273693
68Abnormal gallbladder morphology (HP:0012437)1.81932824
69Bronchomalacia (HP:0002780)1.81464345
70Choanal stenosis (HP:0000452)1.80554313
71Microretrognathia (HP:0000308)1.79860285
72Poikiloderma (HP:0001029)1.78126555
73Large eyes (HP:0001090)1.77648883
74Abnormality of the umbilical cord (HP:0010881)1.77431563
75Male infertility (HP:0003251)1.76194458
76Abnormal hand bone ossification (HP:0010660)1.76053218
77Germ cell neoplasia (HP:0100728)1.75549468
78Myelomeningocele (HP:0002475)1.73398239
79Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72098089
80Abnormality of the gallbladder (HP:0005264)1.69751837
81Anterior segment dysgenesis (HP:0007700)1.69478359
82Bell-shaped thorax (HP:0001591)1.68209785
83Hypolipoproteinemia (HP:0010981)1.67807802
84Flattened epiphyses (HP:0003071)1.66744725
85Easy fatigability (HP:0003388)1.66463579
86Spinal canal stenosis (HP:0003416)1.65908087
87Broad face (HP:0000283)1.65410476
88Diaphragmatic weakness (HP:0009113)1.63284029
89Late onset (HP:0003584)1.61151302
90Premature ovarian failure (HP:0008209)1.60060126
91Seborrheic dermatitis (HP:0001051)1.59478120
92Diminished motivation (HP:0000745)1.58874063
93Delayed epiphyseal ossification (HP:0002663)1.57793692
94Apathy (HP:0000741)1.57791438
95Abnormal atrioventricular conduction (HP:0005150)1.57434762
96Hypergonadotropic hypogonadism (HP:0000815)1.56769399
97Microglossia (HP:0000171)1.56726441
98Hypoplastic pelvis (HP:0008839)1.55916654
99Rickets (HP:0002748)1.55397979
100Hypokinesia (HP:0002375)1.54654283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB38.86524583
2PKN24.21555937
3MUSK3.54688452
4ARAF3.54556036
5EPHA23.33690593
6EEF2K3.33384430
7SIK12.59098920
8STK162.52951203
9MAP3K92.22709200
10CDK122.21889347
11TESK11.98309623
12TESK21.91503746
13MAPK151.89914410
14ICK1.85712551
15MAPKAPK31.68425807
16BRAF1.66098360
17ERN11.60795465
18ILK1.50009976
19PRPF4B1.40133116
20BCKDK1.34474296
21PDPK11.34127909
22FGFR41.33479452
23PRKCI1.30876332
24WNK41.29157231
25NEK61.26880937
26MAP3K131.25188968
27SMG11.14956301
28NME21.13245941
29CAMKK11.08732648
30IRAK31.00153021
31PTK60.99439498
32MTOR0.99114119
33DYRK1B0.97690516
34LRRK20.97188254
35CDK70.94344939
36TAOK20.93801952
37RIPK10.90273102
38AURKA0.85672108
39PIM20.84900273
40PTK20.83158111
41MET0.79232612
42RPS6KB20.77549439
43VRK20.77472979
44PDK10.75951258
45TBK10.73568497
46WNK10.73514629
47SIK20.71430182
48MARK20.70820646
49CAMK1D0.68427976
50CDK90.66398770
51RET0.66324025
52PAK40.65176714
53TNK20.64928935
54KSR20.64915633
55GRK60.61898714
56PRKD20.57119938
57IRAK20.55663650
58RPS6KA20.53919994
59STK390.53082162
60STK240.52422847
61BRSK10.49748031
62NTRK20.49712722
63MAP3K10.48472526
64CHUK0.46380732
65PRKD30.45307226
66MAP2K20.45205110
67MST1R0.43589869
68AKT20.42257718
69STK380.41249758
70LMTK20.40802564
71SIK30.34970628
72MAP3K110.34551632
73MAPK110.32689297
74MELK0.32134972
75MAP3K30.32011794
76TAOK10.31919726
77BMX0.31751221
78HIPK20.31526478
79PRKD10.31003522
80PRKCZ0.30960881
81TYRO30.28894562
82CSNK1D0.27638455
83MAPK80.26596270
84RAF10.26185426
85CDK11A0.24218027
86PRKG20.24107022
87MAPKAPK20.23528889
88CDK150.21322089
89CDK20.20273232
90CAMK40.19273530
91RPS6KC10.19174521
92RPS6KL10.19174521
93DDR20.17866140
94RPS6KB10.17765311
95IKBKE0.17159338
96TRIM280.17111951
97CDK180.16820701
98CAMK2G0.16766235
99GSK3B0.16321821
100CDK10.15803458

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041222.99155612
2Fructose and mannose metabolism_Homo sapiens_hsa000512.47736002
3Phenylalanine metabolism_Homo sapiens_hsa003602.31669170
4Arginine biosynthesis_Homo sapiens_hsa002202.23666077
5Complement and coagulation cascades_Homo sapiens_hsa046102.08635962
6Ovarian steroidogenesis_Homo sapiens_hsa049131.99069604
7Sphingolipid metabolism_Homo sapiens_hsa006001.88552013
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88081800
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87836120
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86997922
11Biosynthesis of amino acids_Homo sapiens_hsa012301.81108978
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.69872174
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.65276128
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63758317
15Bile secretion_Homo sapiens_hsa049761.53549932
16mTOR signaling pathway_Homo sapiens_hsa041501.50763690
17Endometrial cancer_Homo sapiens_hsa052131.44017479
18Notch signaling pathway_Homo sapiens_hsa043301.43168734
19Longevity regulating pathway - mammal_Homo sapiens_hsa042111.41044029
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37438709
21Other glycan degradation_Homo sapiens_hsa005111.32745866
22AMPK signaling pathway_Homo sapiens_hsa041521.32452865
23Tyrosine metabolism_Homo sapiens_hsa003501.32066000
24VEGF signaling pathway_Homo sapiens_hsa043701.28358588
25Insulin resistance_Homo sapiens_hsa049311.27610200
26Insulin signaling pathway_Homo sapiens_hsa049101.27176840
27Non-small cell lung cancer_Homo sapiens_hsa052231.27152800
28Steroid biosynthesis_Homo sapiens_hsa001001.26304563
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20985876
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.20650802
31Vibrio cholerae infection_Homo sapiens_hsa051101.17941777
32Inositol phosphate metabolism_Homo sapiens_hsa005621.16874655
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16297321
34Lysine degradation_Homo sapiens_hsa003101.14826409
35PPAR signaling pathway_Homo sapiens_hsa033201.08974854
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.06002736
37Histidine metabolism_Homo sapiens_hsa003401.04791848
38Fatty acid biosynthesis_Homo sapiens_hsa000611.04760016
39Glucagon signaling pathway_Homo sapiens_hsa049221.02716781
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02541143
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98872043
42Base excision repair_Homo sapiens_hsa034100.98596198
43Acute myeloid leukemia_Homo sapiens_hsa052210.96894566
44Arginine and proline metabolism_Homo sapiens_hsa003300.93204422
45Estrogen signaling pathway_Homo sapiens_hsa049150.90857013
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.90580841
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90237615
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89201430
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89190056
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88550168
51ErbB signaling pathway_Homo sapiens_hsa040120.88348730
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87455613
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86625913
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84027933
55Pentose phosphate pathway_Homo sapiens_hsa000300.83639195
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.83478652
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83239208
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82867780
59Cocaine addiction_Homo sapiens_hsa050300.81525820
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80788241
61Prion diseases_Homo sapiens_hsa050200.80381361
62Thyroid cancer_Homo sapiens_hsa052160.78196780
63N-Glycan biosynthesis_Homo sapiens_hsa005100.77813762
64ABC transporters_Homo sapiens_hsa020100.76472143
65Fatty acid degradation_Homo sapiens_hsa000710.74077006
66Thyroid hormone synthesis_Homo sapiens_hsa049180.73110761
67Fat digestion and absorption_Homo sapiens_hsa049750.72173898
68Prostate cancer_Homo sapiens_hsa052150.70750418
69Fatty acid elongation_Homo sapiens_hsa000620.70118382
70Pyruvate metabolism_Homo sapiens_hsa006200.69814210
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68810076
72Tight junction_Homo sapiens_hsa045300.63317290
73Vitamin digestion and absorption_Homo sapiens_hsa049770.63249089
74Carbon metabolism_Homo sapiens_hsa012000.62664624
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62243199
76Vitamin B6 metabolism_Homo sapiens_hsa007500.60967305
77Caffeine metabolism_Homo sapiens_hsa002320.60424342
78Fatty acid metabolism_Homo sapiens_hsa012120.60231290
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.59521397
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59072405
81Synaptic vesicle cycle_Homo sapiens_hsa047210.58915412
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.58238441
83Basal transcription factors_Homo sapiens_hsa030220.57598885
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55407899
85Hepatitis C_Homo sapiens_hsa051600.54141727
86Circadian rhythm_Homo sapiens_hsa047100.52647209
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.52282299
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.52020507
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51531744
90Choline metabolism in cancer_Homo sapiens_hsa052310.49430259
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48830470
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48714737
93Gap junction_Homo sapiens_hsa045400.47229608
94Chronic myeloid leukemia_Homo sapiens_hsa052200.46337971
95Galactose metabolism_Homo sapiens_hsa000520.45619701
96Renal cell carcinoma_Homo sapiens_hsa052110.45447883
97Glioma_Homo sapiens_hsa052140.42634801
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42519461
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42079544
100HIF-1 signaling pathway_Homo sapiens_hsa040660.40463203

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