CNKSR3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to hepatocyte growth factor (GO:0035728)5.21955092
2cellular response to hepatocyte growth factor stimulus (GO:0035729)5.21955092
3behavioral response to nicotine (GO:0035095)5.20108048
4semaphorin-plexin signaling pathway (GO:0071526)4.99932256
5positive regulation of catenin import into nucleus (GO:0035413)4.98472612
6peripheral nervous system axon ensheathment (GO:0032292)4.67510679
7myelination in peripheral nervous system (GO:0022011)4.67510679
8indolalkylamine metabolic process (GO:0006586)4.47082577
9L-fucose catabolic process (GO:0042355)4.33887558
10fucose catabolic process (GO:0019317)4.33887558
11L-fucose metabolic process (GO:0042354)4.33887558
12indole-containing compound catabolic process (GO:0042436)4.27100676
13indolalkylamine catabolic process (GO:0046218)4.27100676
14tryptophan catabolic process (GO:0006569)4.27100676
15cholesterol biosynthetic process (GO:0006695)4.12940864
16kynurenine metabolic process (GO:0070189)3.98813127
17ensheathment of neurons (GO:0007272)3.98628418
18axon ensheathment (GO:0008366)3.98628418
19cellular response to ethanol (GO:0071361)3.94840234
20myelination (GO:0042552)3.90967728
21adhesion of symbiont to host cell (GO:0044650)3.85599452
22virion attachment to host cell (GO:0019062)3.85599452
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.83332625
24creatine metabolic process (GO:0006600)3.83288788
25tryptophan metabolic process (GO:0006568)3.75262396
26glyoxylate metabolic process (GO:0046487)3.73892750
27nephron tubule morphogenesis (GO:0072078)3.71264692
28nephron epithelium morphogenesis (GO:0072088)3.71264692
29regulation of endothelial cell chemotaxis (GO:2001026)3.67525383
30lens fiber cell development (GO:0070307)3.61885932
31cellular ketone body metabolic process (GO:0046950)3.61351810
32sterol biosynthetic process (GO:0016126)3.58257650
33positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.55605933
34indole-containing compound metabolic process (GO:0042430)3.51837021
35regulation of hippo signaling (GO:0035330)3.51211794
36adult feeding behavior (GO:0008343)3.43694548
37regulation of cardioblast differentiation (GO:0051890)3.42496778
38positive regulation of actin filament depolymerization (GO:0030836)3.42144637
39adhesion of symbiont to host (GO:0044406)3.41126966
40activated T cell proliferation (GO:0050798)3.39870803
41water-soluble vitamin biosynthetic process (GO:0042364)3.35983252
42kidney morphogenesis (GO:0060993)3.32475408
43inositol phosphate-mediated signaling (GO:0048016)3.31274891
44blood vessel maturation (GO:0001955)3.29974468
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.29055472
46heart trabecula formation (GO:0060347)3.28083916
47drug catabolic process (GO:0042737)3.26734158
48exogenous drug catabolic process (GO:0042738)3.25036332
49sarcomere organization (GO:0045214)3.23418479
50regulation of catenin import into nucleus (GO:0035412)3.22645949
51primary amino compound metabolic process (GO:1901160)3.21979884
52ketone body metabolic process (GO:1902224)3.17605965
53oxidative demethylation (GO:0070989)3.15892927
54protein import into peroxisome matrix (GO:0016558)3.12267105
55NADPH regeneration (GO:0006740)3.08174077
56gamma-aminobutyric acid transport (GO:0015812)3.07018236
57serotonin metabolic process (GO:0042428)3.06911175
58negative regulation of translation, ncRNA-mediated (GO:0040033)3.06386433
59regulation of translation, ncRNA-mediated (GO:0045974)3.06386433
60negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06386433
61reflex (GO:0060004)3.06386121
62cardiac myofibril assembly (GO:0055003)3.04950316
63sulfation (GO:0051923)3.04412823
64detection of light stimulus involved in visual perception (GO:0050908)3.03919160
65detection of light stimulus involved in sensory perception (GO:0050962)3.03919160
66acetyl-CoA metabolic process (GO:0006084)3.02856697
67response to pheromone (GO:0019236)3.00342176
68negative regulation of interleukin-1 beta production (GO:0032691)2.99819670
69Rap protein signal transduction (GO:0032486)2.98889364
70regulation of collateral sprouting (GO:0048670)2.98422027
71NAD biosynthetic process (GO:0009435)2.97125682
72peristalsis (GO:0030432)2.94091600
73aromatic amino acid family catabolic process (GO:0009074)2.92552632
74hindbrain development (GO:0030902)2.89917408
75polarized epithelial cell differentiation (GO:0030859)2.89768900
76multicellular organism reproduction (GO:0032504)2.88208966
77negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.86722982
78tricarboxylic acid metabolic process (GO:0072350)2.86633585
79L-amino acid import (GO:0043092)2.85729510
80neuronal action potential (GO:0019228)2.84886927
81auditory receptor cell stereocilium organization (GO:0060088)2.83949342
82plasma membrane repair (GO:0001778)2.82772864
83cornea development in camera-type eye (GO:0061303)2.81847821
84renal tubule morphogenesis (GO:0061333)2.81321418
85regulation of mesoderm development (GO:2000380)2.79401082
86membrane protein ectodomain proteolysis (GO:0006509)2.78759911
87ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.78210406
88regulation of alkaline phosphatase activity (GO:0010692)2.76069815
89pericardium development (GO:0060039)2.75308221
902-oxoglutarate metabolic process (GO:0006103)2.74738821
91regulation of gene silencing by RNA (GO:0060966)2.73507087
92regulation of posttranscriptional gene silencing (GO:0060147)2.73507087
93regulation of gene silencing by miRNA (GO:0060964)2.73507087
94establishment of epithelial cell polarity (GO:0090162)2.73298053
95regulation of myelination (GO:0031641)2.72926841
96protein K11-linked deubiquitination (GO:0035871)2.72317206
97negative regulation of telomere maintenance (GO:0032205)2.71604861
98cilium organization (GO:0044782)2.68641013
99cellular biogenic amine catabolic process (GO:0042402)2.68123145
100amine catabolic process (GO:0009310)2.68123145
101cilium or flagellum-dependent cell motility (GO:0001539)2.66780494
102positive regulation of neurological system process (GO:0031646)2.64912213
103growth hormone secretion (GO:0030252)2.64772499
104C4-dicarboxylate transport (GO:0015740)2.64418363
105inner ear receptor stereocilium organization (GO:0060122)2.63273390
106negative regulation of interleukin-1 production (GO:0032692)2.62987313
107fucosylation (GO:0036065)2.62784840
108fatty acid elongation (GO:0030497)2.61345302
109axoneme assembly (GO:0035082)2.61237614
110cellular response to ATP (GO:0071318)2.60960267
111cellular response to epinephrine stimulus (GO:0071872)2.59272564
112cilium assembly (GO:0042384)2.59209106
113endosome to melanosome transport (GO:0035646)2.58906900
114endosome to pigment granule transport (GO:0043485)2.58906900
115basement membrane organization (GO:0071711)2.57365413
116positive regulation of fatty acid beta-oxidation (GO:0032000)2.57054125
117negative regulation of systemic arterial blood pressure (GO:0003085)2.56395182
118behavioral response to ethanol (GO:0048149)2.56343791
119protein ADP-ribosylation (GO:0006471)2.56212238
120negative regulation of striated muscle cell apoptotic process (GO:0010664)2.56042058
121positive regulation of triglyceride biosynthetic process (GO:0010867)2.55797412
122transcytosis (GO:0045056)2.55518641
123spinal cord motor neuron differentiation (GO:0021522)2.54922831
124amino acid import (GO:0043090)2.53660399
125cysteine metabolic process (GO:0006534)2.53436127
126neurotransmitter metabolic process (GO:0042133)2.52720724
127skin morphogenesis (GO:0043589)2.52408294
128UDP-N-acetylglucosamine metabolic process (GO:0006047)2.52278787
129trabecula formation (GO:0060343)2.52058912
130renal filtration (GO:0097205)2.51922381
131negative regulation of smooth muscle cell migration (GO:0014912)2.50304224
132positive regulation of CREB transcription factor activity (GO:0032793)2.49910425
133fatty acid beta-oxidation (GO:0006635)2.49373362
134phasic smooth muscle contraction (GO:0014821)2.49281399
135regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.48716065
136regulation of cholesterol homeostasis (GO:2000188)2.48296789
137glomerular basement membrane development (GO:0032836)2.48274531
138alkaloid metabolic process (GO:0009820)2.47974573
139response to redox state (GO:0051775)2.47808250
140negative regulation of reactive oxygen species metabolic process (GO:2000378)2.47180679
141negative regulation of Rho protein signal transduction (GO:0035024)2.47145477
142regulation of phospholipid biosynthetic process (GO:0071071)2.46810497
143negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46778318
144regulation of nuclear cell cycle DNA replication (GO:0033262)2.46606450
145glomerular filtration (GO:0003094)2.46462722
146signal peptide processing (GO:0006465)2.45304468
147nonmotile primary cilium assembly (GO:0035058)2.44904910
148negative regulation of potassium ion transmembrane transport (GO:1901380)2.44348430
149macroautophagy (GO:0016236)2.44184716
150positive regulation of developmental pigmentation (GO:0048087)2.44115567
151membrane depolarization during action potential (GO:0086010)2.43977021
152cilium movement (GO:0003341)2.43774698
153histone H4 deacetylation (GO:0070933)2.43745314
154cardiac muscle cell development (GO:0055013)2.43681031
155cardiac cell development (GO:0055006)2.42315257
156platelet-derived growth factor receptor signaling pathway (GO:0048008)2.41950773
157positive regulation of fatty acid oxidation (GO:0046321)2.41861401
158cardiac muscle tissue morphogenesis (GO:0055008)2.41494788
159DNA deamination (GO:0045006)2.41247253
160reciprocal DNA recombination (GO:0035825)2.40951063
161reciprocal meiotic recombination (GO:0007131)2.40951063
162endothelial cell morphogenesis (GO:0001886)2.40854924
1633-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.40746856
164purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.40746856
165aromatic amino acid family metabolic process (GO:0009072)2.39680499
166negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.39522459
167cell morphogenesis involved in neuron differentiation (GO:0048667)2.38241533
168negative regulation of sodium ion transport (GO:0010766)2.37841846
169epithelial cell-cell adhesion (GO:0090136)2.37035411
170alpha-linolenic acid metabolic process (GO:0036109)2.36994207
171epithelial cilium movement (GO:0003351)2.36400295
172rRNA catabolic process (GO:0016075)2.35455389
173myofibril assembly (GO:0030239)2.35195648
174regulation of hexokinase activity (GO:1903299)2.34994494
175regulation of glucokinase activity (GO:0033131)2.34994494
176central nervous system myelination (GO:0022010)2.34985518
177axon ensheathment in central nervous system (GO:0032291)2.34985518
178neural tube formation (GO:0001841)2.34872850
179coronary vasculature morphogenesis (GO:0060977)2.33895729
180cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.33560114
181lysine catabolic process (GO:0006554)2.33533714
182lysine metabolic process (GO:0006553)2.33533714
183regulation of lamellipodium organization (GO:1902743)2.32991233
184maternal placenta development (GO:0001893)2.32350227
185tricarboxylic acid cycle (GO:0006099)2.31653063
186valine metabolic process (GO:0006573)2.31300570
187dermatan sulfate biosynthetic process (GO:0030208)2.30843753
188acyl-CoA biosynthetic process (GO:0071616)2.29644476
189thioester biosynthetic process (GO:0035384)2.29644476
190regulation of p38MAPK cascade (GO:1900744)2.28547586
191adherens junction assembly (GO:0034333)2.28392280
192cholesterol metabolic process (GO:0008203)2.26197765
193regulation of cell proliferation involved in kidney development (GO:1901722)2.23913314
194branching involved in salivary gland morphogenesis (GO:0060445)2.23365498
195regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.23175649
196apoptotic process involved in morphogenesis (GO:0060561)2.21213122
197isoprenoid biosynthetic process (GO:0008299)2.19611052
198apoptotic cell clearance (GO:0043277)2.18632538
199bundle of His cell to Purkinje myocyte communication (GO:0086069)2.18549435
200positive regulation of p38MAPK cascade (GO:1900745)2.18072354

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.88532970
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.64286707
3EZH2_22144423_ChIP-Seq_EOC_Human3.28637143
4CLOCK_20551151_ChIP-Seq_293T_Human3.11055269
5VDR_22108803_ChIP-Seq_LS180_Human3.07881738
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.99885302
7GBX2_23144817_ChIP-Seq_PC3_Human2.90452891
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.85797910
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67843276
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.61767551
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.60412931
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.58138006
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.40557479
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38966542
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.38851369
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.36062346
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.31840124
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25697590
19* LXR_22158963_ChIP-Seq_LIVER_Mouse2.25493435
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.25333223
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.17079806
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.17079806
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.17079806
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12864778
25EP300_21415370_ChIP-Seq_HL-1_Mouse2.11905423
26TRIM28_21343339_ChIP-Seq_HEK293_Human2.09858662
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09434741
28TBX20_22328084_ChIP-Seq_HEART_Mouse2.02620910
29TBX20_22080862_ChIP-Seq_HEART_Mouse2.02620910
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02073604
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93059728
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.91294481
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.89655410
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89622931
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.88743376
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86617734
37* P300_19829295_ChIP-Seq_ESCs_Human1.85709656
38EWS_26573619_Chip-Seq_HEK293_Human1.84574499
39* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.84196337
40ER_23166858_ChIP-Seq_MCF-7_Human1.84089796
41AR_21572438_ChIP-Seq_LNCaP_Human1.84079730
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81065806
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.79615029
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.75600490
45* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75245116
46STAT3_23295773_ChIP-Seq_U87_Human1.74323014
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.74229954
48FUS_26573619_Chip-Seq_HEK293_Human1.73802609
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.72769970
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71703454
51RACK7_27058665_Chip-Seq_MCF-7_Human1.71391848
52KDM2B_26808549_Chip-Seq_DND41_Human1.71340427
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68436320
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.67959433
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.65947472
56ZNF263_19887448_ChIP-Seq_K562_Human1.65835960
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.64897934
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64722074
59TAF15_26573619_Chip-Seq_HEK293_Human1.63611934
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62315762
61* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61438428
62BCAT_22108803_ChIP-Seq_LS180_Human1.61299523
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.60948755
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.58747369
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58315615
66* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57581099
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.57082517
68IGF1R_20145208_ChIP-Seq_DFB_Human1.56204510
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56077516
70SMAD4_21799915_ChIP-Seq_A2780_Human1.54318532
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53141418
72GATA2_21666600_ChIP-Seq_HMVEC_Human1.52819638
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52320646
74TCF4_23295773_ChIP-Seq_U87_Human1.51921635
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50034938
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50034938
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49426567
78AR_25329375_ChIP-Seq_VCAP_Human1.48603259
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47778898
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46820207
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46283236
82TP53_16413492_ChIP-PET_HCT116_Human1.45914048
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45491855
84DROSHA_22980978_ChIP-Seq_HELA_Human1.44760465
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.44101241
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43945470
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42881642
88* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42427438
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41103481
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40512790
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40171379
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.37968904
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.37374237
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36797707
95REST_21632747_ChIP-Seq_MESCs_Mouse1.36456745
96AR_21909140_ChIP-Seq_LNCAP_Human1.36294720
97GATA1_19941826_ChIP-Seq_K562_Human1.35795780
98MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.35750456
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34799446
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34635386
101MYC_22102868_ChIP-Seq_BL_Human1.34127985
102* TCF7_22412390_ChIP-Seq_EML_Mouse1.33838963
103PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33836670
104VDR_21846776_ChIP-Seq_THP-1_Human1.31681518
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31384370
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31207325
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31165440
108CBP_20019798_ChIP-Seq_JUKART_Human1.31165440
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31034176
110TCF4_22108803_ChIP-Seq_LS180_Human1.30295546
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28698216
112IRF1_19129219_ChIP-ChIP_H3396_Human1.28175516
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28124933
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28055047
115PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27649487
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27610701
117NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.27281533
118* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26432230
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.26171590
120* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25694119
121* FOXA2_19822575_ChIP-Seq_HepG2_Human1.25451426
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.23919530
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23556153
124RUNX1_27514584_Chip-Seq_MCF-7_Human1.23471557
125SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23398630
126GATA6_25053715_ChIP-Seq_YYC3_Human1.23382350
127TP53_22573176_ChIP-Seq_HFKS_Human1.23042007
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22709175
129* RUNX2_22187159_ChIP-Seq_PCA_Human1.21753357
130* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21594281
131NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21538648
132EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21402267
133ATF3_27146783_Chip-Seq_COLON_Human1.20854703
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20615990
135LXR_22292898_ChIP-Seq_THP-1_Human1.20359204
136NANOG_19829295_ChIP-Seq_ESCs_Human1.18912697
137SOX2_19829295_ChIP-Seq_ESCs_Human1.18912697
138FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18242777
139FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18108799
140UBF1/2_26484160_Chip-Seq_HMECs_Human1.17548956
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17200824
142FOXA1_25329375_ChIP-Seq_VCAP_Human1.16515425
143FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16515425
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16472986
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16302903
146HOXB7_26014856_ChIP-Seq_BT474_Human1.15806153
147SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15038449
148HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14074472
149SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13210854
150SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13115472
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12778506
152* FLI1_21867929_ChIP-Seq_TH2_Mouse1.12335404
153RNF2_27304074_Chip-Seq_NSC_Mouse1.11809330
154KDM2B_26808549_Chip-Seq_JURKAT_Human1.11765321
155* SOX2_20726797_ChIP-Seq_SW620_Human1.11278076
156GATA3_21878914_ChIP-Seq_MCF-7_Human1.10742214
157PRDM14_20953172_ChIP-Seq_ESCs_Human1.10598842
158* GATA4_25053715_ChIP-Seq_YYC3_Human1.09708229
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09554497
160ARNT_22903824_ChIP-Seq_MCF-7_Human1.08413611
161SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08197443
162EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07869234
163RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07822781
164ISL1_27105846_Chip-Seq_CPCs_Mouse1.07701558
165TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07546428
166SMAD3_21741376_ChIP-Seq_ESCs_Human1.06901234
167* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06797284
168KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06744074
169KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06663333
170CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06632527
171VDR_24763502_ChIP-Seq_THP-1_Human1.05948894
172NFE2_27457419_Chip-Seq_LIVER_Mouse1.05283348
173NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04762933
174FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04731898
175JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04452667
176EZH2_27304074_Chip-Seq_ESCs_Mouse1.04020900
177MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03665406
178AHR_22903824_ChIP-Seq_MCF-7_Human1.03538168
179JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03411212
180STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03238150
181SCL_19346495_ChIP-Seq_HPC-7_Human1.03158249
182SMAD3_21741376_ChIP-Seq_HESCs_Human1.02840331
183NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02102840
184SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01165660
185SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01165660
186ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01156111
187EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00876423
188* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00705922
189ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00597662
190UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00497158
191* EZH2_27294783_Chip-Seq_NPCs_Mouse1.00103331
192TP63_19390658_ChIP-ChIP_HaCaT_Human0.99814222
193TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99405906
194GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99081367
195SOX2_21211035_ChIP-Seq_LN229_Gbm0.99023443
196SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98864989
197NANOG_18555785_Chip-Seq_ESCs_Mouse0.98530608
198RUNX_20019798_ChIP-Seq_JUKART_Human0.98412901
199CDX2_20551321_ChIP-Seq_CACO-2_Human0.98086173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.41051814
2MP0005623_abnormal_meninges_morphology3.00015459
3MP0004084_abnormal_cardiac_muscle2.82125452
4MP0008438_abnormal_cutaneous_collagen2.79765391
5MP0002837_dystrophic_cardiac_calcinosis2.77570983
6MP0004272_abnormal_basement_membrane2.71826949
7MP0008872_abnormal_physiological_respon2.58385599
8MP0004043_abnormal_pH_regulation2.57140841
9MP0005551_abnormal_eye_electrophysiolog2.31588889
10MP0009046_muscle_twitch2.27987925
11MP0008875_abnormal_xenobiotic_pharmacok2.23370438
12MP0002876_abnormal_thyroid_physiology2.17002874
13MP0004185_abnormal_adipocyte_glucose2.14344479
14MP0003136_yellow_coat_color2.14080772
15MP0000569_abnormal_digit_pigmentation2.09469790
16MP0001501_abnormal_sleep_pattern2.07616440
17MP0000751_myopathy2.02862745
18MP0005330_cardiomyopathy1.99398443
19MP0002102_abnormal_ear_morphology1.95331384
20MP0009384_cardiac_valve_regurgitation1.89694213
21MP0001968_abnormal_touch/_nociception1.87595253
22MP0003566_abnormal_cell_adhesion1.83967074
23MP0003690_abnormal_glial_cell1.83129863
24MP0004134_abnormal_chest_morphology1.82955858
25MP0002653_abnormal_ependyma_morphology1.79157658
26MP0002638_abnormal_pupillary_reflex1.78568422
27MP0000733_abnormal_muscle_development1.77206214
28MP0003890_abnormal_embryonic-extraembry1.74217942
29MP0002938_white_spotting1.72295084
30MP0004087_abnormal_muscle_fiber1.72187416
31MP0001666_abnormal_nutrient_absorption1.72163073
32MP0002736_abnormal_nociception_after1.68891076
33MP0003868_abnormal_feces_composition1.68871316
34MP0000427_abnormal_hair_cycle1.67901942
35MP0004142_abnormal_muscle_tone1.67467139
36MP0009745_abnormal_behavioral_response1.67289754
37MP0010630_abnormal_cardiac_muscle1.66197480
38MP0004036_abnormal_muscle_relaxation1.62971803
39MP0000749_muscle_degeneration1.62349910
40MP0004145_abnormal_muscle_electrophysio1.60288629
41MP0010329_abnormal_lipoprotein_level1.59723130
42MP0004133_heterotaxia1.58829674
43MP0002735_abnormal_chemical_nociception1.58765383
44MP0001485_abnormal_pinna_reflex1.58465107
45MP0008877_abnormal_DNA_methylation1.56556976
46MP0003119_abnormal_digestive_system1.55994764
47MP0006138_congestive_heart_failure1.53595226
48MP0009278_abnormal_bone_marrow1.52879610
49MP0003950_abnormal_plasma_membrane1.52427124
50MP0000462_abnormal_digestive_system1.50929794
51MP0004885_abnormal_endolymph1.50626263
52MP0002928_abnormal_bile_duct1.46677765
53MP0005646_abnormal_pituitary_gland1.44700425
54MP0005220_abnormal_exocrine_pancreas1.44601006
55MP0004215_abnormal_myocardial_fiber1.42776201
56MP0002160_abnormal_reproductive_system1.41883431
57MP0002272_abnormal_nervous_system1.41339812
58MP0001986_abnormal_taste_sensitivity1.40781890
59MP0000920_abnormal_myelination1.40622802
60MP0002557_abnormal_social/conspecific_i1.39811568
61MP0003828_pulmonary_edema1.39479992
62MP0003385_abnormal_body_wall1.38323761
63MP0000538_abnormal_urinary_bladder1.38164860
64MP0002139_abnormal_hepatobiliary_system1.38108879
65MP0001486_abnormal_startle_reflex1.37232996
66MP0001984_abnormal_olfaction1.36848132
67MP0000383_abnormal_hair_follicle1.34420946
68MP0000631_abnormal_neuroendocrine_gland1.34141021
69MP0005084_abnormal_gallbladder_morpholo1.34107793
70MP0005666_abnormal_adipose_tissue1.32328197
71MP0005167_abnormal_blood-brain_barrier1.31235197
72MP0002108_abnormal_muscle_morphology1.30832399
73MP0006276_abnormal_autonomic_nervous1.29503644
74MP0005645_abnormal_hypothalamus_physiol1.28860613
75MP0004130_abnormal_muscle_cell1.28790280
76MP0005253_abnormal_eye_physiology1.28777237
77MP0002269_muscular_atrophy1.28518821
78MP0002138_abnormal_hepatobiliary_system1.28160857
79MP0010368_abnormal_lymphatic_system1.27907182
80MP0003806_abnormal_nucleotide_metabolis1.26667529
81MP0005386_behavior/neurological_phenoty1.25984430
82MP0004924_abnormal_behavior1.25984430
83MP0005365_abnormal_bile_salt1.25964614
84MP0002733_abnormal_thermal_nociception1.24685553
85MP0003252_abnormal_bile_duct1.23925844
86MP0002572_abnormal_emotion/affect_behav1.22500761
87MP0005275_abnormal_skin_tensile1.21580428
88MP0003646_muscle_fatigue1.20366630
89MP0005385_cardiovascular_system_phenoty1.20319190
90MP0001544_abnormal_cardiovascular_syste1.20319190
91MP0000467_abnormal_esophagus_morphology1.20257054
92MP0005448_abnormal_energy_balance1.20176504
93MP0002106_abnormal_muscle_physiology1.18383230
94MP0002282_abnormal_trachea_morphology1.16881620
95MP0005174_abnormal_tail_pigmentation1.15126731
96MP0003453_abnormal_keratinocyte_physiol1.14593195
97MP0005332_abnormal_amino_acid1.14547557
98MP0002067_abnormal_sensory_capabilities1.14438662
99MP0002128_abnormal_blood_circulation1.14299710
100MP0005375_adipose_tissue_phenotype1.14276000
101MP0000747_muscle_weakness1.13986118
102MP0010030_abnormal_orbit_morphology1.13902209
103MP0002064_seizures1.13778842
104MP0002168_other_aberrant_phenotype1.13752710
105MP0000750_abnormal_muscle_regeneration1.13367075
106MP0003195_calcinosis1.13291634
107MP0006072_abnormal_retinal_apoptosis1.13179165
108MP0000767_abnormal_smooth_muscle1.11880091
109MP0001970_abnormal_pain_threshold1.11864866
110MP0001664_abnormal_digestion1.11269017
111MP0009053_abnormal_anal_canal1.10498749
112MP0002089_abnormal_postnatal_growth/wei1.10019106
113MP0005360_urolithiasis1.09926152
114MP0005083_abnormal_biliary_tract1.09771360
115MP0003567_abnormal_fetal_cardiomyocyte1.09465615
116MP0002972_abnormal_cardiac_muscle1.08853444
117MP0005369_muscle_phenotype1.08279266
118MP0002295_abnormal_pulmonary_circulatio1.08132879
119MP0006292_abnormal_olfactory_placode1.07858065
120MP0000537_abnormal_urethra_morphology1.07827539
121MP0005023_abnormal_wound_healing1.05941767
122MP0000003_abnormal_adipose_tissue1.05798189
123MP0008961_abnormal_basal_metabolism1.05675729
124MP0000230_abnormal_systemic_arterial1.05432033
125MP0003878_abnormal_ear_physiology1.03794073
126MP0005377_hearing/vestibular/ear_phenot1.03794073
127MP0003279_aneurysm1.03714000
128MP0001849_ear_inflammation1.01579010
129MP0001502_abnormal_circadian_rhythm1.01322349
130MP0005389_reproductive_system_phenotype1.00836173
131MP0003137_abnormal_impulse_conducting1.00261412
132MP0004197_abnormal_fetal_growth/weight/0.99444744
133MP0002925_abnormal_cardiovascular_devel0.99173290
134MP0004742_abnormal_vestibular_system0.98886231
135MP0003283_abnormal_digestive_organ0.98228054
136MP0000266_abnormal_heart_morphology0.97973513
137MP0002734_abnormal_mechanical_nocicepti0.97229359
138MP0010386_abnormal_urinary_bladder0.96506907
139MP0003221_abnormal_cardiomyocyte_apopto0.96373808
140MP0003091_abnormal_cell_migration0.96345600
141MP0003984_embryonic_growth_retardation0.95958008
142MP0005508_abnormal_skeleton_morphology0.95857055
143MP0003011_delayed_dark_adaptation0.95346968
144MP0002088_abnormal_embryonic_growth/wei0.94913070
145MP0009250_abnormal_appendicular_skeleto0.94867652
146MP0005195_abnormal_posterior_eye0.94652877
147MP0000470_abnormal_stomach_morphology0.94576498
148MP0001614_abnormal_blood_vessel0.93145341
149MP0000026_abnormal_inner_ear0.92935477
150MP0002063_abnormal_learning/memory/cond0.92838497
151MP0002909_abnormal_adrenal_gland0.92424135
152MP0000762_abnormal_tongue_morphology0.91856758
153MP0000759_abnormal_skeletal_muscle0.91432342
154MP0002693_abnormal_pancreas_physiology0.90967088
155MP0005503_abnormal_tendon_morphology0.90036342
156MP0003300_gastrointestinal_ulcer0.89406746
157MP0008775_abnormal_heart_ventricle0.89245503
158MP0001299_abnormal_eye_distance/0.88919083
159MP0001919_abnormal_reproductive_system0.87314086
160MP0003937_abnormal_limbs/digits/tail_de0.86769802
161MP0002234_abnormal_pharynx_morphology0.86015626
162MP0005085_abnormal_gallbladder_physiolo0.85877763
163MP0002896_abnormal_bone_mineralization0.85267587
164MP0001944_abnormal_pancreas_morphology0.83343052
165MP0001756_abnormal_urination0.80912179
166MP0002111_abnormal_tail_morphology0.79269796
167MP0003959_abnormal_lean_body0.77954980
168MP0001697_abnormal_embryo_size0.77481158
169MP0003115_abnormal_respiratory_system0.77417716
170MP0001324_abnormal_eye_pigmentation0.77072234
171MP0002085_abnormal_embryonic_tissue0.76768738
172MP0003953_abnormal_hormone_level0.76615243
173MP0001784_abnormal_fluid_regulation0.76598537
174MP0003935_abnormal_craniofacial_develop0.76507418
175MP0001730_embryonic_growth_arrest0.76450444
176MP0002060_abnormal_skin_morphology0.76423788
177MP0000163_abnormal_cartilage_morphology0.76261781
178MP0004147_increased_porphyrin_level0.75814188
179MP0006054_spinal_hemorrhage0.74692357
180MP0000428_abnormal_craniofacial_morphol0.74664708
181MP0001963_abnormal_hearing_physiology0.73738298
182MP0003698_abnormal_male_reproductive0.73672975

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.75127842
2Pancreatic cysts (HP:0001737)4.61741391
3Pancreatic fibrosis (HP:0100732)4.30724290
4Type II lissencephaly (HP:0007260)4.26531025
5Hyperventilation (HP:0002883)4.20197678
6Multiple enchondromatosis (HP:0005701)4.01970935
7Abnormality of midbrain morphology (HP:0002418)3.86577780
8Molar tooth sign on MRI (HP:0002419)3.86577780
9True hermaphroditism (HP:0010459)3.81973249
10Congenital stationary night blindness (HP:0007642)3.69598980
11Small epiphyses (HP:0010585)3.67335310
12Nephronophthisis (HP:0000090)3.66964572
13Epiphyseal dysplasia (HP:0002656)3.53608970
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.52022307
15Abnormality of alanine metabolism (HP:0010916)3.52022307
16Hyperalaninemia (HP:0003348)3.52022307
17Metaphyseal cupping (HP:0003021)3.50430599
18Lymphangioma (HP:0100764)3.43107064
19Tubular atrophy (HP:0000092)3.41835297
20Genetic anticipation (HP:0003743)3.40790377
21Broad metatarsal (HP:0001783)3.37611102
22Premature skin wrinkling (HP:0100678)3.31911935
23Abnormality of the renal cortex (HP:0011035)3.29698643
24Abnormality of the renal medulla (HP:0100957)3.24452913
25Abnormal cartilage morphology (HP:0002763)3.21882683
26Protrusio acetabuli (HP:0003179)3.11995898
27Ankle contracture (HP:0006466)3.09141797
28Attenuation of retinal blood vessels (HP:0007843)3.05555725
29Cerebellar dysplasia (HP:0007033)3.03675865
30Cystic liver disease (HP:0006706)3.01459902
31Breast hypoplasia (HP:0003187)2.99109907
32Inability to walk (HP:0002540)2.98494381
33Scapular winging (HP:0003691)2.97178598
34Abnormality of the parathyroid morphology (HP:0011766)2.97110486
35Ventricular tachycardia (HP:0004756)2.96002266
36Premature rupture of membranes (HP:0001788)2.95431619
37Ulnar bowing (HP:0003031)2.93133951
38Patellar aplasia (HP:0006443)2.91990689
39Hypoplastic ischia (HP:0003175)2.91809041
40Chronic hepatic failure (HP:0100626)2.89625446
41Right ventricular cardiomyopathy (HP:0011663)2.83999102
42Hemorrhage of the eye (HP:0011885)2.83001650
43Chorioretinal atrophy (HP:0000533)2.81612670
44Increased connective tissue (HP:0009025)2.80527064
45Large for gestational age (HP:0001520)2.79086819
46Protruding tongue (HP:0010808)2.77754161
47Shallow orbits (HP:0000586)2.74250373
48Aplasia/Hypoplasia of the patella (HP:0006498)2.71385142
49Hyporeflexia of lower limbs (HP:0002600)2.71256115
50Progressive cerebellar ataxia (HP:0002073)2.71005733
51Muscle fiber splitting (HP:0003555)2.68477837
52Gaze-evoked nystagmus (HP:0000640)2.64728754
53Cupped ribs (HP:0000887)2.64478099
54Sudden death (HP:0001699)2.62799763
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.58437145
56Lissencephaly (HP:0001339)2.57573092
57Abnormality of the pons (HP:0007361)2.55602004
58Thick nail (HP:0001805)2.51707380
59Clumsiness (HP:0002312)2.49548642
60Progressive inability to walk (HP:0002505)2.47763844
61Abnormality of the ischium (HP:0003174)2.47754112
62Increased corneal curvature (HP:0100692)2.45711219
63Keratoconus (HP:0000563)2.45711219
64Fair hair (HP:0002286)2.44400718
65Pendular nystagmus (HP:0012043)2.43788218
66Vertebral clefting (HP:0008428)2.38426064
67Abolished electroretinogram (ERG) (HP:0000550)2.36918578
68Hypoplasia of the pons (HP:0012110)2.35792455
69Medial flaring of the eyebrow (HP:0010747)2.35391014
70Broad-based gait (HP:0002136)2.35084560
71Exostoses (HP:0100777)2.33547576
72Duplicated collecting system (HP:0000081)2.32659200
73Lipoatrophy (HP:0100578)2.32165479
74Polydipsia (HP:0001959)2.32000346
75Abnormal drinking behavior (HP:0030082)2.32000346
76Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.31119361
77Sclerocornea (HP:0000647)2.30739156
78Sensory axonal neuropathy (HP:0003390)2.29982096
79Bowing of the arm (HP:0006488)2.27806966
80Bowed forearm bones (HP:0003956)2.27806966
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.27286950
82Abnormal vertebral ossification (HP:0100569)2.26244413
83Cerebral aneurysm (HP:0004944)2.26235016
84Abnormality of the renal collecting system (HP:0004742)2.24907869
85Irregular epiphyses (HP:0010582)2.24643397
86Depressed nasal tip (HP:0000437)2.24187623
87Furrowed tongue (HP:0000221)2.24153578
88Dynein arm defect of respiratory motile cilia (HP:0012255)2.20557555
89Absent/shortened dynein arms (HP:0200106)2.20557555
90Myoglobinuria (HP:0002913)2.19791370
91Male pseudohermaphroditism (HP:0000037)2.19398757
92Visceral angiomatosis (HP:0100761)2.19058793
93Blue sclerae (HP:0000592)2.18810068
94Dilated cardiomyopathy (HP:0001644)2.16908257
95Hypoplastic labia majora (HP:0000059)2.16861973
96Difficulty running (HP:0009046)2.15847335
97Polyuria (HP:0000103)2.15464181
98Anomalous pulmonary venous return (HP:0010772)2.13908379
99Concave nail (HP:0001598)2.13129059
100Delayed epiphyseal ossification (HP:0002663)2.13025838
101Difficulty climbing stairs (HP:0003551)2.12984953
102Hemangiomatosis (HP:0007461)2.12772420
103Decreased circulating renin level (HP:0003351)2.11533537
104Abnormality of the calf musculature (HP:0001430)2.11275617
105Bile duct proliferation (HP:0001408)2.10086570
106Abnormal biliary tract physiology (HP:0012439)2.10086570
107Rhabdomyolysis (HP:0003201)2.08794732
108Widely spaced teeth (HP:0000687)2.06609232
109Retinal dysplasia (HP:0007973)2.06100620
110Aplasia/Hypoplasia involving the musculature (HP:0001460)2.06049979
111Congenital, generalized hypertrichosis (HP:0004540)2.04711230
112Increased variability in muscle fiber diameter (HP:0003557)2.03719369
113Congenital hepatic fibrosis (HP:0002612)2.02906655
114Mesangial abnormality (HP:0001966)2.02369908
115Abnormality of the labia majora (HP:0012881)2.02047130
116Decreased central vision (HP:0007663)2.01557405
117Limb-girdle muscle atrophy (HP:0003797)2.01192900
118Anencephaly (HP:0002323)1.99758569
119Absent hand (HP:0004050)1.99311249
120Turricephaly (HP:0000262)1.98912234
121Abnormal ciliary motility (HP:0012262)1.98424139
122Hypothermia (HP:0002045)1.97576331
123Renal cortical cysts (HP:0000803)1.97492553
124Platyspondyly (HP:0000926)1.97141091
125Deep venous thrombosis (HP:0002625)1.96963222
126EMG: myopathic abnormalities (HP:0003458)1.96350144
127Absent speech (HP:0001344)1.95292603
128Coronal craniosynostosis (HP:0004440)1.94209930
129Stridor (HP:0010307)1.94183776
130Abnormality of the left ventricular outflow tract (HP:0011103)1.93939300
131Subaortic stenosis (HP:0001682)1.93939300
132Hypoplastic nipples (HP:0002557)1.93405663
133Flat acetabular roof (HP:0003180)1.93322472
134Pachygyria (HP:0001302)1.92886490
135Abnormality of the pulmonary veins (HP:0011718)1.92492585
136Lumbar hyperlordosis (HP:0002938)1.91908791
137Prominent supraorbital ridges (HP:0000336)1.90621087
138Abnormality of the salivary glands (HP:0010286)1.90544721
139Congenital sensorineural hearing impairment (HP:0008527)1.90141940
140Aneurysm (HP:0002617)1.89282966
141Calf muscle hypertrophy (HP:0008981)1.88680441
142Wide anterior fontanel (HP:0000260)1.88318898
143Pseudobulbar signs (HP:0002200)1.88292856
144Radial bowing (HP:0002986)1.87903645
145Muscle hypertrophy of the lower extremities (HP:0008968)1.87159525
146Cerebral hypomyelination (HP:0006808)1.87114219
147Exercise-induced muscle cramps (HP:0003710)1.86997910
148Disproportionate short-trunk short stature (HP:0003521)1.86866942
149Hemiparesis (HP:0001269)1.86335244
150Hypoplastic pelvis (HP:0008839)1.86029803
151Severe muscular hypotonia (HP:0006829)1.85432196
152Abnormal respiratory motile cilium morphology (HP:0005938)1.84825890
153Abnormal respiratory epithelium morphology (HP:0012253)1.84825890
154Supernumerary ribs (HP:0005815)1.84429881
155Microretrognathia (HP:0000308)1.84110967
156Thin ribs (HP:0000883)1.83712504
157Mild short stature (HP:0003502)1.83333835
158Abnormal urine output (HP:0012590)1.83070752
159Abnormality of the vitreous humor (HP:0004327)1.82171263
160Rhizomelia (HP:0008905)1.81516552
161Generalized hypopigmentation of hair (HP:0011358)1.81150306
162Partial agenesis of the corpus callosum (HP:0001338)1.80579416
163Spinal rigidity (HP:0003306)1.80521912
164Genital tract atresia (HP:0001827)1.80064264
165Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78035396
166Abnormality of the peritoneum (HP:0002585)1.77023445
167Dandy-Walker malformation (HP:0001305)1.77014007
168Exercise-induced myalgia (HP:0003738)1.76345355
169Tachypnea (HP:0002789)1.76109612
170Postaxial foot polydactyly (HP:0001830)1.75411582
171Optic nerve hypoplasia (HP:0000609)1.75204609
172Abnormality of skeletal muscle fiber size (HP:0012084)1.74419809
173Aortic dissection (HP:0002647)1.72922612
174Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72123274
175Degeneration of the lateral corticospinal tracts (HP:0002314)1.72123274
176Deep palmar crease (HP:0006191)1.71170115
177Aortic aneurysm (HP:0004942)1.70974208
178Gait imbalance (HP:0002141)1.70436950
179Ketoacidosis (HP:0001993)1.70348003
180Global brain atrophy (HP:0002283)1.70237520
181Pterygium (HP:0001059)1.69390403
182Small hand (HP:0200055)1.69267855
183Ovoid vertebral bodies (HP:0003300)1.68766302
184Hypoalbuminemia (HP:0003073)1.68734710
185Abnormal albumin level (HP:0012116)1.68734710
186Cervical subluxation (HP:0003308)1.68607756
187Type 1 muscle fiber predominance (HP:0003803)1.68502430
188Ketosis (HP:0001946)1.68324672
189Double outlet right ventricle (HP:0001719)1.68154460
190Congenital malformation of the right heart (HP:0011723)1.68154460
191Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68085957
192Congenital primary aphakia (HP:0007707)1.66992855
193Peritonitis (HP:0002586)1.65378054
194Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.64364091
195Vertebral hypoplasia (HP:0008417)1.64364091
196Intrahepatic cholestasis (HP:0001406)1.60362207
197Achilles tendon contracture (HP:0001771)1.60174737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.24535148
2INSRR4.64148617
3EPHB14.62990682
4BMPR1B4.04778955
5TYRO33.66083981
6TNIK3.57227251
7PKN23.20019722
8ADRBK23.02190988
9STK392.98724951
10TTN2.91295593
11TAOK32.72158634
12ICK2.53580721
13LATS12.52656491
14SIK12.40668393
15GRK12.38425196
16TRIB32.23553185
17RIPK12.23494865
18CASK2.20108937
19TLK12.03082160
20DAPK21.91843023
21WNK31.86954709
22ZAK1.85573516
23MKNK21.84387812
24DMPK1.77998320
25PNCK1.76545652
26TIE11.76088186
27FLT31.67079117
28PAK41.66621036
29RPS6KB21.62132647
30PTK61.61919311
31EEF2K1.59121890
32BCKDK1.58417601
33PTK21.54702514
34AKT31.52203296
35DDR21.51555748
36MAP4K21.47234656
37ERN11.45219198
38ADRBK11.39186427
39WNK41.37601265
40CDK121.36512016
41PDGFRB1.35629664
42PDGFRA1.33781309
43PINK11.31250076
44CSK1.30175226
45TGFBR11.28492458
46PKN11.27012611
47MAPK151.26469568
48FES1.24515243
49STK38L1.22497660
50STK31.22240631
51OXSR11.19834586
52CAMK1D1.17677527
53PIK3CA1.16520199
54MET1.16203782
55MAP3K41.15363705
56KDR1.11355867
57ROCK11.11236691
58MAP3K31.08685056
59CAMK1G1.08029182
60NEK21.05407709
61MAP3K101.04445267
62ROCK21.04422219
63PAK21.02275613
64MAPKAPK30.98084284
65BMX0.97561329
66IRAK10.97325614
67MTOR0.95695548
68NLK0.93872788
69IRAK20.92642337
70LRRK20.90936641
71CAMKK10.90130709
72PAK30.86523825
73TGFBR20.84506238
74TBK10.84470340
75PRKD10.83929387
76UHMK10.82045576
77NTRK30.81997318
78PRKCG0.80414440
79MAP2K60.79435203
80MAP2K30.78886935
81MKNK10.78870346
82STK110.77070842
83STK40.76821078
84PTK2B0.72187590
85IRAK40.71907471
86WNK10.71741781
87GSK3A0.71666732
88EPHA20.71639389
89PRKCE0.71293396
90FGFR40.70732228
91MELK0.69689462
92RPS6KA50.68210181
93MYLK0.65880171
94PHKG20.65868118
95PHKG10.65868118
96RET0.65594101
97FGFR10.65064907
98RPS6KA60.64393010
99WEE10.62590004
100CDK80.62347337
101STK100.60137902
102PRKAA10.59118077
103TRPM70.58874156
104LMTK20.57882282
105SIK20.57041283
106MAPKAPK50.55448730
107TXK0.53842064
108MARK10.53750275
109MUSK0.52815458
110TEC0.52230189
111MAP2K10.50786192
112NME10.50765126
113CAMK10.50671823
114SGK20.50334824
115FGFR20.49360519
116MAPK130.47066894
117CAMK2A0.46892742
118MAP2K20.46755781
119INSR0.46645632
120CSF1R0.46634450
121PRKD20.45841575
122IKBKB0.45164656
123MAP3K20.42914386
124EPHB20.42731177
125PRKCZ0.42238567
126ACVR1B0.41068491
127CSNK1A10.39471471
128CHUK0.39162407
129IKBKE0.39048402
130PRKACA0.37618888
131NTRK20.37041868
132PRKG20.36628109
133CHEK20.35519867
134ALK0.35079433
135ABL20.34316134
136CAMK40.33436722
137PRKCQ0.33380415
138CSNK1D0.32932516
139TNK20.32725552
140BTK0.32528404
141CAMKK20.32456434
142ILK0.31573176
143SGK4940.31457804
144SGK2230.31457804
145MST40.31225688
146VRK10.30973478
147NUAK10.30835619
148PRKCA0.30776740
149PRKAA20.30653900
150SRC0.29827956
151PIK3CG0.29327276
152MAP2K70.29149833
153MAPK10.28844975
154CDK70.28058017
155PRKG10.27870037
156NEK90.27363054
157ERBB20.27357787
158FER0.26096546
159BRSK20.25888052
160LATS20.25417241
161RPS6KB10.25177361
162OBSCN0.24925615
163CAMK2D0.24449483
164ERBB40.24329558
165CDK40.24284116
166MAP3K70.24251694
167STK380.24161690
168MAPK110.23471000
169RPS6KA30.23328522
170MARK20.23252973
171CDK90.23238394
172DYRK1B0.22580328

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.08911170
2Steroid biosynthesis_Homo sapiens_hsa001003.18212041
3Linoleic acid metabolism_Homo sapiens_hsa005913.00498130
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.84678953
5Fatty acid degradation_Homo sapiens_hsa000712.77206350
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.73022312
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69693262
8Fatty acid metabolism_Homo sapiens_hsa012122.59549861
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.58517048
10Fatty acid elongation_Homo sapiens_hsa000622.35741564
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29518399
12ECM-receptor interaction_Homo sapiens_hsa045122.25978481
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.21454495
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15266942
15Phototransduction_Homo sapiens_hsa047442.14730174
16Caffeine metabolism_Homo sapiens_hsa002322.14566213
17Propanoate metabolism_Homo sapiens_hsa006402.12033012
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97199466
19Nicotine addiction_Homo sapiens_hsa050331.87020332
20ABC transporters_Homo sapiens_hsa020101.81140468
21Focal adhesion_Homo sapiens_hsa045101.79291500
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.79205578
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71556120
24Butanoate metabolism_Homo sapiens_hsa006501.70145303
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.67847685
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65503719
27Viral myocarditis_Homo sapiens_hsa054161.64516109
28Histidine metabolism_Homo sapiens_hsa003401.62681310
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61659842
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60496626
31Homologous recombination_Homo sapiens_hsa034401.56886594
32Protein digestion and absorption_Homo sapiens_hsa049741.56106472
33Chemical carcinogenesis_Homo sapiens_hsa052041.51371359
34Retinol metabolism_Homo sapiens_hsa008301.51247361
35Taste transduction_Homo sapiens_hsa047421.43126512
36Sulfur metabolism_Homo sapiens_hsa009201.40430517
37Lysine degradation_Homo sapiens_hsa003101.39301742
38Fat digestion and absorption_Homo sapiens_hsa049751.37112975
39Carbon metabolism_Homo sapiens_hsa012001.35238737
40Proteoglycans in cancer_Homo sapiens_hsa052051.30339501
41Adherens junction_Homo sapiens_hsa045201.29611084
42PPAR signaling pathway_Homo sapiens_hsa033201.26595136
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26472659
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.25585967
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23934723
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23592645
47Fatty acid biosynthesis_Homo sapiens_hsa000611.23547124
48Basal transcription factors_Homo sapiens_hsa030221.22153190
49Insulin secretion_Homo sapiens_hsa049111.19997920
50Tryptophan metabolism_Homo sapiens_hsa003801.19729693
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19694797
52Pyruvate metabolism_Homo sapiens_hsa006201.19499504
53Arginine and proline metabolism_Homo sapiens_hsa003301.17705835
54Notch signaling pathway_Homo sapiens_hsa043301.17517553
55Dilated cardiomyopathy_Homo sapiens_hsa054141.17199947
56Fanconi anemia pathway_Homo sapiens_hsa034601.16628467
57Olfactory transduction_Homo sapiens_hsa047401.14026030
58Tight junction_Homo sapiens_hsa045301.13122545
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13052758
60Biosynthesis of amino acids_Homo sapiens_hsa012301.12029024
61Ovarian steroidogenesis_Homo sapiens_hsa049131.10591540
62Arachidonic acid metabolism_Homo sapiens_hsa005901.10561641
63Pentose and glucuronate interconversions_Homo sapiens_hsa000401.09372302
64Peroxisome_Homo sapiens_hsa041461.08816059
65Small cell lung cancer_Homo sapiens_hsa052221.08476305
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08411741
67Serotonergic synapse_Homo sapiens_hsa047261.08089062
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08052043
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06783028
70MicroRNAs in cancer_Homo sapiens_hsa052061.02804436
71Platelet activation_Homo sapiens_hsa046111.02260253
72Morphine addiction_Homo sapiens_hsa050321.01296230
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99274396
74Vitamin digestion and absorption_Homo sapiens_hsa049770.97826584
75Insulin resistance_Homo sapiens_hsa049310.97702797
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96138824
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.96074695
78Hippo signaling pathway_Homo sapiens_hsa043900.94770640
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.94566571
80Axon guidance_Homo sapiens_hsa043600.93797496
81One carbon pool by folate_Homo sapiens_hsa006700.93676348
82Amoebiasis_Homo sapiens_hsa051460.93593173
83TGF-beta signaling pathway_Homo sapiens_hsa043500.88518078
84Mineral absorption_Homo sapiens_hsa049780.87350540
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86249015
86Basal cell carcinoma_Homo sapiens_hsa052170.83639658
87Vitamin B6 metabolism_Homo sapiens_hsa007500.83587378
88Glutamatergic synapse_Homo sapiens_hsa047240.83262506
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81716804
90Circadian entrainment_Homo sapiens_hsa047130.81696049
91GABAergic synapse_Homo sapiens_hsa047270.81179193
92RNA polymerase_Homo sapiens_hsa030200.80863221
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80272185
94Ether lipid metabolism_Homo sapiens_hsa005650.80178776
95Chronic myeloid leukemia_Homo sapiens_hsa052200.79822615
96Renal cell carcinoma_Homo sapiens_hsa052110.79582253
97Calcium signaling pathway_Homo sapiens_hsa040200.79177857
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77307848
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.75129816
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74452591
101Acute myeloid leukemia_Homo sapiens_hsa052210.72659548
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72376621
103Glutathione metabolism_Homo sapiens_hsa004800.72144880
104Cocaine addiction_Homo sapiens_hsa050300.71352066
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71116981
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70347816
107Selenocompound metabolism_Homo sapiens_hsa004500.69384060
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68954272
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68427292
110Prostate cancer_Homo sapiens_hsa052150.67983914
111beta-Alanine metabolism_Homo sapiens_hsa004100.66035444
112AMPK signaling pathway_Homo sapiens_hsa041520.65750615
113Circadian rhythm_Homo sapiens_hsa047100.63462126
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.61831137
115Oxidative phosphorylation_Homo sapiens_hsa001900.61537123
116Pancreatic secretion_Homo sapiens_hsa049720.59459126
117Salivary secretion_Homo sapiens_hsa049700.58069526
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.56413236
119Arginine biosynthesis_Homo sapiens_hsa002200.55776736
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55706056
121Pancreatic cancer_Homo sapiens_hsa052120.55672824
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54549081
123Toxoplasmosis_Homo sapiens_hsa051450.54515511
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53962256
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.53650324
126Bile secretion_Homo sapiens_hsa049760.53584741
127Dorso-ventral axis formation_Homo sapiens_hsa043200.52716866
128Tyrosine metabolism_Homo sapiens_hsa003500.51741429
129Pentose phosphate pathway_Homo sapiens_hsa000300.51113530
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50892702
131Shigellosis_Homo sapiens_hsa051310.50486673
132mTOR signaling pathway_Homo sapiens_hsa041500.49997210
133Metabolic pathways_Homo sapiens_hsa011000.49718758
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.49253780
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.49235532
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48886737
137cAMP signaling pathway_Homo sapiens_hsa040240.45700905
138Protein export_Homo sapiens_hsa030600.45283431
139Cardiac muscle contraction_Homo sapiens_hsa042600.44501460
140Long-term depression_Homo sapiens_hsa047300.44028491
141Type II diabetes mellitus_Homo sapiens_hsa049300.43972821
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43623877
143Apoptosis_Homo sapiens_hsa042100.43399153
144Thyroid hormone synthesis_Homo sapiens_hsa049180.42884843
145Hedgehog signaling pathway_Homo sapiens_hsa043400.42469611
146Dopaminergic synapse_Homo sapiens_hsa047280.41214914
147Complement and coagulation cascades_Homo sapiens_hsa046100.40545071
148Cyanoamino acid metabolism_Homo sapiens_hsa004600.39718449
149Folate biosynthesis_Homo sapiens_hsa007900.39612764
150Malaria_Homo sapiens_hsa051440.39479519
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39105583
152Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38898655
153Starch and sucrose metabolism_Homo sapiens_hsa005000.38335838
154Amphetamine addiction_Homo sapiens_hsa050310.38331536
155Thyroid cancer_Homo sapiens_hsa052160.37431946
156Bladder cancer_Homo sapiens_hsa052190.35578415
157Cysteine and methionine metabolism_Homo sapiens_hsa002700.35321798
158Sulfur relay system_Homo sapiens_hsa041220.35095657
159Cholinergic synapse_Homo sapiens_hsa047250.35084087
160Pathways in cancer_Homo sapiens_hsa052000.33076449
161Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32370652
162Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32070947
163Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30373638
164Nitrogen metabolism_Homo sapiens_hsa009100.30232006
165Choline metabolism in cancer_Homo sapiens_hsa052310.29808552
166Colorectal cancer_Homo sapiens_hsa052100.29760937
167Glycerolipid metabolism_Homo sapiens_hsa005610.29226113
168Maturity onset diabetes of the young_Homo sapiens_hsa049500.29131645
169B cell receptor signaling pathway_Homo sapiens_hsa046620.27429916

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