CNGA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* detection of light stimulus (GO:0009583)9.86875049
2* detection of visible light (GO:0009584)9.76138057
3retinal rod cell development (GO:0046548)9.58682143
4sphingoid metabolic process (GO:0046519)9.54721639
5regulation of guanylate cyclase activity (GO:0031282)9.05370841
6* visual perception (GO:0007601)8.69099680
7protein-chromophore linkage (GO:0018298)8.68790748
8* sensory perception of light stimulus (GO:0050953)8.59901909
9eye photoreceptor cell differentiation (GO:0001754)7.67075593
10photoreceptor cell differentiation (GO:0046530)7.67075593
11* cellular response to light stimulus (GO:0071482)7.26484824
12* detection of external stimulus (GO:0009581)6.87778323
13retina development in camera-type eye (GO:0060041)6.76809501
14* detection of abiotic stimulus (GO:0009582)6.76339435
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.76311620
16L-phenylalanine catabolic process (GO:0006559)6.76311620
17regulation of cGMP metabolic process (GO:0030823)6.49619528
18DNA methylation involved in gamete generation (GO:0043046)6.41383135
19regulation of meiosis I (GO:0060631)6.28469961
20positive regulation of cGMP biosynthetic process (GO:0030828)5.88422897
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.85661200
22L-phenylalanine metabolic process (GO:0006558)5.85661200
23lipopolysaccharide biosynthetic process (GO:0009103)5.80903054
24regulation of odontogenesis of dentin-containing tooth (GO:0042487)5.70355197
25heme transport (GO:0015886)5.57918858
26regulation of cGMP biosynthetic process (GO:0030826)5.50948462
27sulfate transmembrane transport (GO:1902358)5.45635696
28regulation of protein glycosylation (GO:0060049)5.36703302
29aromatic amino acid family catabolic process (GO:0009074)5.34532248
30cell morphogenesis involved in neuron differentiation (GO:0048667)5.27973294
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.23856069
32positive regulation of cGMP metabolic process (GO:0030825)5.17335092
33negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.11014152
34nonmotile primary cilium assembly (GO:0035058)5.09639111
35tyrosine metabolic process (GO:0006570)5.08489820
36receptor guanylyl cyclase signaling pathway (GO:0007168)5.07592605
37lipopolysaccharide metabolic process (GO:0008653)4.99356569
38drug catabolic process (GO:0042737)4.94847363
39piRNA metabolic process (GO:0034587)4.93134111
40exogenous drug catabolic process (GO:0042738)4.89494830
41detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.80343026
42sulfate transport (GO:0008272)4.77001438
43* cellular response to radiation (GO:0071478)4.73709115
44adaptation of signaling pathway (GO:0023058)4.69358208
45positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.62416190
46flavonoid metabolic process (GO:0009812)4.58698529
47* regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.43459136
48regulation of pigment cell differentiation (GO:0050932)4.39945603
49positive regulation of developmental pigmentation (GO:0048087)4.29506947
50negative regulation of cell cycle G2/M phase transition (GO:1902750)4.25371244
51negative regulation of glycoprotein biosynthetic process (GO:0010561)4.24984442
52centriole replication (GO:0007099)4.20113169
53epoxygenase P450 pathway (GO:0019373)4.19838737
54* sensory perception (GO:0007600)4.18839578
55aromatic amino acid family metabolic process (GO:0009072)4.17509950
56retina layer formation (GO:0010842)4.15234046
57regulation of voltage-gated calcium channel activity (GO:1901385)4.13752076
58tryptophan catabolic process (GO:0006569)4.08506139
59indole-containing compound catabolic process (GO:0042436)4.08506139
60indolalkylamine catabolic process (GO:0046218)4.08506139
61omega-hydroxylase P450 pathway (GO:0097267)4.04069842
62drug metabolic process (GO:0017144)4.01241773
63prenylation (GO:0097354)3.99981029
64protein prenylation (GO:0018342)3.99981029
65regulation of triglyceride catabolic process (GO:0010896)3.96928398
66indolalkylamine metabolic process (GO:0006586)3.96035523
67iron coordination entity transport (GO:1901678)3.95787657
68glycerol metabolic process (GO:0006071)3.94810419
69oxidative demethylation (GO:0070989)3.92988688
70positive regulation of meiosis (GO:0045836)3.86383852
71short-term memory (GO:0007614)3.83399036
72ribonucleoprotein complex disassembly (GO:0032988)3.79288816
73neuron development (GO:0048666)3.76648152
74* response to light stimulus (GO:0009416)3.74246085
75vitamin transmembrane transport (GO:0035461)3.74236899
76estrogen biosynthetic process (GO:0006703)3.73456290
77retina homeostasis (GO:0001895)3.72352746
78cellular glucuronidation (GO:0052695)3.71035435
79positive regulation of meiotic cell cycle (GO:0051446)3.65733595
80regulation of penile erection (GO:0060405)3.63122772
81paraxial mesoderm development (GO:0048339)3.62526623
82behavioral response to ethanol (GO:0048149)3.61432407
83alditol metabolic process (GO:0019400)3.61289229
84uronic acid metabolic process (GO:0006063)3.59238081
85glucuronate metabolic process (GO:0019585)3.59238081
86regulation of clathrin-mediated endocytosis (GO:2000369)3.58509381
87bile acid metabolic process (GO:0008206)3.57943305
88regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.57133467
89chemosensory behavior (GO:0007635)3.53344160
90protein localization to synapse (GO:0035418)3.51847317
91urate metabolic process (GO:0046415)3.46862136
92amino-acid betaine metabolic process (GO:0006577)3.44448210
93glyoxylate metabolic process (GO:0046487)3.42696850
94nodal signaling pathway (GO:0038092)3.41804898
95organelle disassembly (GO:1903008)3.41427128
96amine catabolic process (GO:0009310)3.40721667
97cellular biogenic amine catabolic process (GO:0042402)3.40721667
98DNA deamination (GO:0045006)3.39392215
99regulation of nuclear cell cycle DNA replication (GO:0033262)3.39373815
100aspartate family amino acid catabolic process (GO:0009068)3.37676013
101regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.36735282
102regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.36735282
103positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.34169799
104tryptophan metabolic process (GO:0006568)3.33109380
105meiotic chromosome segregation (GO:0045132)3.31340072
106positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.27679560
107toxin metabolic process (GO:0009404)3.26683182
108negative regulation of receptor-mediated endocytosis (GO:0048261)3.24646413
109negative regulation of glycoprotein metabolic process (GO:1903019)3.22166232
110response to histamine (GO:0034776)3.21376839
111pantothenate metabolic process (GO:0015939)3.21186526
112lysine catabolic process (GO:0006554)3.21094710
113lysine metabolic process (GO:0006553)3.21094710
114cellular ketone body metabolic process (GO:0046950)3.15762496
115positive regulation of neurotransmitter transport (GO:0051590)3.13421377
116notochord development (GO:0030903)3.13029413
117response to mercury ion (GO:0046689)3.11181130
118axoneme assembly (GO:0035082)3.09883048
119kynurenine metabolic process (GO:0070189)3.07676281
120positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.04359577
121amino acid salvage (GO:0043102)3.02460759
122L-methionine salvage (GO:0071267)3.02460759
123L-methionine biosynthetic process (GO:0071265)3.02460759
124membrane hyperpolarization (GO:0060081)3.01370030
125sulfur compound transport (GO:0072348)3.01081450
126positive regulation of sodium ion transmembrane transport (GO:1902307)3.00338007
127S-adenosylmethionine metabolic process (GO:0046500)2.99622758
128xenobiotic catabolic process (GO:0042178)2.97003128
129protein heterotetramerization (GO:0051290)2.95228103
130somite rostral/caudal axis specification (GO:0032525)2.95103556
131serotonin receptor signaling pathway (GO:0007210)2.94287969
132bile acid biosynthetic process (GO:0006699)2.92722556
133tachykinin receptor signaling pathway (GO:0007217)2.90762704
134serine family amino acid catabolic process (GO:0009071)2.87593091
135alkaloid metabolic process (GO:0009820)2.84382671
136detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.84279080
137alpha-amino acid catabolic process (GO:1901606)2.84196504
138regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84022246
139benzene-containing compound metabolic process (GO:0042537)2.83082320
140detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.82966740
141response to nitrosative stress (GO:0051409)2.82629235
142positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.82201389
143phenylpropanoid metabolic process (GO:0009698)2.81839712
144peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.81052836
145gamma-aminobutyric acid signaling pathway (GO:0007214)2.79907712
146cofactor transport (GO:0051181)2.79073011
147drug transmembrane transport (GO:0006855)2.77857905
148behavioral response to nicotine (GO:0035095)2.77528722
149retinoid metabolic process (GO:0001523)2.77497178
150positive regulation of fatty acid oxidation (GO:0046321)2.75276338
151SMAD protein complex assembly (GO:0007183)2.73351973
152ketone body metabolic process (GO:1902224)2.72467289
153arachidonic acid secretion (GO:0050482)2.72203140
154icosanoid secretion (GO:0032309)2.72203140
155negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.72195169
156CDP-diacylglycerol biosynthetic process (GO:0016024)2.70556955
157positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.70466258
158indole-containing compound metabolic process (GO:0042430)2.70367384
159glycine metabolic process (GO:0006544)2.69739928
160L-fucose metabolic process (GO:0042354)2.68225576
161negative regulation of cation channel activity (GO:2001258)2.64280907
162behavioral response to cocaine (GO:0048148)2.63335575
163righting reflex (GO:0060013)2.62443448
164synaptic transmission, dopaminergic (GO:0001963)2.62189181
165* response to radiation (GO:0009314)2.61899803
166negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60968627
167detection of chemical stimulus involved in sensory perception (GO:0050907)2.59343738
168diterpenoid metabolic process (GO:0016101)2.56559568
169sensory perception of smell (GO:0007608)2.56465202
170lipid translocation (GO:0034204)2.56313321
171phospholipid translocation (GO:0045332)2.56313321
172retinol metabolic process (GO:0042572)2.56216312
173negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.54973246
174negative regulation of calcium ion transmembrane transport (GO:1903170)2.54973246
175positive regulation of ERBB signaling pathway (GO:1901186)2.52317320
176dopamine receptor signaling pathway (GO:0007212)2.52024321
177CDP-diacylglycerol metabolic process (GO:0046341)2.39806264
178positive regulation of cyclase activity (GO:0031281)2.39309307
179* cellular response to abiotic stimulus (GO:0071214)2.37653641
180positive regulation of membrane potential (GO:0045838)2.37225364
181regulation of catecholamine metabolic process (GO:0042069)2.36397689
182regulation of dopamine metabolic process (GO:0042053)2.36397689
183regulation of neurotransmitter uptake (GO:0051580)2.35757672
184terpenoid metabolic process (GO:0006721)2.32983854
185post-embryonic morphogenesis (GO:0009886)2.30530672
186* regulation of rhodopsin mediated signaling pathway (GO:0022400)18.1711360
187* rhodopsin mediated signaling pathway (GO:0016056)17.7392513
188retinal cone cell development (GO:0046549)15.1751226
189photoreceptor cell development (GO:0042461)12.5052044
190photoreceptor cell maintenance (GO:0045494)12.3671424
191eye photoreceptor cell development (GO:0042462)11.9452363
192sphingosine metabolic process (GO:0006670)11.2560626
193detection of light stimulus involved in visual perception (GO:0050908)10.8524082
194detection of light stimulus involved in sensory perception (GO:0050962)10.8524082
195* phototransduction (GO:0007602)10.4248387
196GMP metabolic process (GO:0046037)10.4000442
197* phototransduction, visible light (GO:0007603)10.2428754
198diol metabolic process (GO:0034311)10.2381253
199positive regulation of guanylate cyclase activity (GO:0031284)10.0451961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.83472277
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.39795701
3VDR_22108803_ChIP-Seq_LS180_Human3.38654070
4GBX2_23144817_ChIP-Seq_PC3_Human3.16879691
5ZNF274_21170338_ChIP-Seq_K562_Hela2.92199196
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.74764021
7* FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.59545133
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57247664
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14672450
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12074638
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.10984167
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.06407173
13DROSHA_22980978_ChIP-Seq_HELA_Human2.04952460
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04353829
15CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95492654
16AR_21572438_ChIP-Seq_LNCaP_Human1.88176091
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87079001
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85317466
19NANOG_19829295_ChIP-Seq_ESCs_Human1.82771734
20SOX2_19829295_ChIP-Seq_ESCs_Human1.82771734
21IGF1R_20145208_ChIP-Seq_DFB_Human1.78192640
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75385085
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.74480658
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74350846
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70847382
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69687078
27CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67586658
28HOXB7_26014856_ChIP-Seq_BT474_Human1.66639654
29SMAD3_21741376_ChIP-Seq_HESCs_Human1.65866314
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64893914
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64365926
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.63777417
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62950138
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61809787
35DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61266046
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58744102
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58744102
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56996207
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56949007
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.56523662
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.54015041
42SMAD4_21799915_ChIP-Seq_A2780_Human1.53749984
43REST_21632747_ChIP-Seq_MESCs_Mouse1.52318150
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52011223
45AR_25329375_ChIP-Seq_VCAP_Human1.50926289
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49512540
47* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.49236491
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49169713
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47391984
50P300_19829295_ChIP-Seq_ESCs_Human1.47239042
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46315925
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.45955440
53TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.43726401
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.43074639
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43074639
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.42306525
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.41640044
58AR_19668381_ChIP-Seq_PC3_Human1.41412674
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40946753
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39761112
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.39405369
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39394716
63CBP_20019798_ChIP-Seq_JUKART_Human1.39394716
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38149943
65TCF4_22108803_ChIP-Seq_LS180_Human1.37681837
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35946743
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.35935506
68EZH2_22144423_ChIP-Seq_EOC_Human1.35751379
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35599765
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.35455799
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33900191
72TAF15_26573619_Chip-Seq_HEK293_Human1.33800472
73FUS_26573619_Chip-Seq_HEK293_Human1.33664999
74STAT3_23295773_ChIP-Seq_U87_Human1.32191478
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31223070
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.29916548
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.29284364
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.29185239
79TBL1_22424771_ChIP-Seq_293T_Human1.29153543
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28018298
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27895947
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27223889
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.26559172
84SMAD4_21741376_ChIP-Seq_EPCs_Human1.25783882
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.24571841
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24498431
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23228166
88CDX2_22108803_ChIP-Seq_LS180_Human1.21901280
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21765568
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21640822
91BCAT_22108803_ChIP-Seq_LS180_Human1.21150729
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21133986
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20893914
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20725265
95OCT4_20526341_ChIP-Seq_ESCs_Human1.20601487
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20026675
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19529462
98ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19410562
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17153978
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14457815
101TCF4_23295773_ChIP-Seq_U87_Human1.13451487
102EED_16625203_ChIP-ChIP_MESCs_Mouse1.13105237
103FOXH1_21741376_ChIP-Seq_ESCs_Human1.12749997
104ER_23166858_ChIP-Seq_MCF-7_Human1.12293226
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12201372
106EP300_21415370_ChIP-Seq_HL-1_Mouse1.12114534
107MYC_19829295_ChIP-Seq_ESCs_Human1.11926214
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11848294
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11318353
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.11306572
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11121107
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09970276
113GF1_26923725_Chip-Seq_HPCs_Mouse1.09875112
114AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09798702
115NOTCH1_21737748_ChIP-Seq_TLL_Human1.09636977
116OCT1_27270436_Chip-Seq_PROSTATE_Human1.09625484
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09112959
118CEBPB_22108803_ChIP-Seq_LS180_Human1.08953464
119STAT1_20625510_ChIP-Seq_HELA_Human1.07195875
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07082972
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07082972
122E2F1_18555785_Chip-Seq_ESCs_Mouse1.07023648
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06994481
124RNF2_27304074_Chip-Seq_NSC_Mouse1.06874255
125NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.06552112
126CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05956414
127CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05802148
128HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05646876
129STAT3_18555785_Chip-Seq_ESCs_Mouse1.05623201
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05530325
131P53_21459846_ChIP-Seq_SAOS-2_Human1.05422478
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05063920
133NANOG_20526341_ChIP-Seq_ESCs_Human1.04752149
134WDR5_24793694_ChIP-Seq_LNCAP_Human1.04461051
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04016362
136RARB_27405468_Chip-Seq_BRAIN_Mouse1.03638313
137E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02850847
138KDM2B_26808549_Chip-Seq_K562_Human1.02579083
139NFE2_27457419_Chip-Seq_LIVER_Mouse1.02311384
140CMYC_18555785_Chip-Seq_ESCs_Mouse1.02163558
141SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01725837
142EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00924954
143SALL1_21062744_ChIP-ChIP_HESCs_Human1.00846587
144MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00824686
145RXR_22158963_ChIP-Seq_LIVER_Mouse1.00536808
146LXR_22158963_ChIP-Seq_LIVER_Mouse0.99416782
147NCOR_22424771_ChIP-Seq_293T_Human0.99072406
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98987837
149TAL1_26923725_Chip-Seq_HPCs_Mouse0.98332688
150ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98308578
151ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97815224
152CBP_21632823_ChIP-Seq_H3396_Human0.97727334
153SMAD4_21741376_ChIP-Seq_HESCs_Human0.97612257
154KDM2B_26808549_Chip-Seq_REH_Human0.97396001
155EWS_26573619_Chip-Seq_HEK293_Human0.97309358
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.96996137
157TAF2_19829295_ChIP-Seq_ESCs_Human0.95578447
158EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94792269
159SOX2_18555785_Chip-Seq_ESCs_Mouse0.94128829
160FLI1_27457419_Chip-Seq_LIVER_Mouse0.93959335
161PIAS1_25552417_ChIP-Seq_VCAP_Human0.93381848
162RUNX2_22187159_ChIP-Seq_PCA_Human0.92476371
163CTCF_27219007_Chip-Seq_Bcells_Human0.91343722
164SMAD3_21741376_ChIP-Seq_EPCs_Human0.90973658
165YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90244515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.71847115
2MP0002837_dystrophic_cardiac_calcinosis7.69613162
3MP0005253_abnormal_eye_physiology6.92173637
4MP0006072_abnormal_retinal_apoptosis6.45553703
5MP0003136_yellow_coat_color5.93888898
6MP0005171_absent_coat_pigmentation4.99501669
7MP0003950_abnormal_plasma_membrane4.12255560
8MP0005085_abnormal_gallbladder_physiolo4.02793553
9MP0002138_abnormal_hepatobiliary_system3.98921793
10MP0005195_abnormal_posterior_eye3.88821462
11MP0003195_calcinosis3.54453300
12MP0001324_abnormal_eye_pigmentation3.49796271
13MP0005391_vision/eye_phenotype3.34213376
14MP0005365_abnormal_bile_salt3.27793230
15MP0002638_abnormal_pupillary_reflex3.26965868
16MP0005423_abnormal_somatic_nervous2.76383930
17MP0000569_abnormal_digit_pigmentation2.69761241
18MP0002139_abnormal_hepatobiliary_system2.68292491
19MP0002090_abnormal_vision2.67213548
20MP0005670_abnormal_white_adipose2.64627844
21MP0003879_abnormal_hair_cell2.63692810
22MP0008875_abnormal_xenobiotic_pharmacok2.59381536
23MP0001986_abnormal_taste_sensitivity2.58905170
24MP0002229_neurodegeneration2.57365440
25MP0001764_abnormal_homeostasis2.16799400
26MP0005360_urolithiasis2.10561956
27MP0003252_abnormal_bile_duct2.10085985
28MP0004147_increased_porphyrin_level2.03500133
29MP0002752_abnormal_somatic_nervous2.00431348
30MP0003011_delayed_dark_adaptation10.7447602
31MP0002938_white_spotting1.92404237
32MP0004381_abnormal_hair_follicle1.75348039
33MP0002876_abnormal_thyroid_physiology1.73999361
34MP0002168_other_aberrant_phenotype1.63875418
35MP0005075_abnormal_melanosome_morpholog1.42220439
36MP0000749_muscle_degeneration1.41250557
37MP0002882_abnormal_neuron_morphology1.40819535
38MP0008872_abnormal_physiological_respon1.36950173
39MP0001984_abnormal_olfaction1.32694373
40MP0005395_other_phenotype1.31204520
41MP0004019_abnormal_vitamin_homeostasis1.30168722
42MP0006292_abnormal_olfactory_placode1.25717304
43MP0002653_abnormal_ependyma_morphology1.18319377
44MP0010329_abnormal_lipoprotein_level1.14903471
45MP0005332_abnormal_amino_acid1.12081268
46MP0001666_abnormal_nutrient_absorption1.11243888
47MP0002254_reproductive_system_inflammat1.11208472
48MP0001502_abnormal_circadian_rhythm1.10006204
49MP0000427_abnormal_hair_cycle1.09143435
50MP0002160_abnormal_reproductive_system1.09054891
51MP0002095_abnormal_skin_pigmentation1.08848022
52MP0005197_abnormal_uvea_morphology1.07988419
53MP0001486_abnormal_startle_reflex0.97275458
54MP0004885_abnormal_endolymph0.95294460
55MP0002163_abnormal_gland_morphology0.93913082
56MP0005394_taste/olfaction_phenotype0.91325175
57MP0005499_abnormal_olfactory_system0.91325175
58MP0003718_maternal_effect0.89731269
59MP0002332_abnormal_exercise_endurance0.88678470
60MP0005319_abnormal_enzyme/_coenzyme0.86273909
61MP0002735_abnormal_chemical_nociception0.85208355
62MP0004270_analgesia0.83812830
63MP0002272_abnormal_nervous_system0.83078755
64MP0008789_abnormal_olfactory_epithelium0.82778105
65MP0003137_abnormal_impulse_conducting0.81548252
66MP0002277_abnormal_respiratory_mucosa0.81143062
67MP0005174_abnormal_tail_pigmentation0.79573045
68MP0004233_abnormal_muscle_weight0.79368011
69MP0003634_abnormal_glial_cell0.77858727
70MP0003806_abnormal_nucleotide_metabolis0.77574748
71MP0005187_abnormal_penis_morphology0.76945799
72MP0002127_abnormal_cardiovascular_syste0.76711051
73MP0009764_decreased_sensitivity_to0.75579033
74MP0005410_abnormal_fertilization0.74300254
75MP0002075_abnormal_coat/hair_pigmentati0.74123518
76MP0003880_abnormal_central_pattern0.74064130
77MP0003868_abnormal_feces_composition0.73366659
78MP0002102_abnormal_ear_morphology0.70940194
79MP0002118_abnormal_lipid_homeostasis0.68853155
80MP0005389_reproductive_system_phenotype0.68442806
81MP0006276_abnormal_autonomic_nervous0.68248737
82MP0001963_abnormal_hearing_physiology0.66611238
83MP0006036_abnormal_mitochondrial_physio0.66055304
84MP0005377_hearing/vestibular/ear_phenot0.65729844
85MP0003878_abnormal_ear_physiology0.65729844
86MP0002269_muscular_atrophy0.63019884
87MP0009046_muscle_twitch0.62332887
88MP0008877_abnormal_DNA_methylation0.62227274
89MP0005379_endocrine/exocrine_gland_phen0.61626690
90MP0002734_abnormal_mechanical_nocicepti0.61485975
91MP0005330_cardiomyopathy0.60376556
92MP0010352_gastrointestinal_tract_polyps0.59473640
93MP0001485_abnormal_pinna_reflex0.58971235
94MP0001286_abnormal_eye_development0.57680456
95MP0000230_abnormal_systemic_arterial0.55850506
96MP0002736_abnormal_nociception_after0.55659365
97MP0002064_seizures0.55559354
98MP0005266_abnormal_metabolism0.53912262
99MP0002067_abnormal_sensory_capabilities0.50262207
100MP0002971_abnormal_brown_adipose0.50198184
101MP0003635_abnormal_synaptic_transmissio0.49777451
102MP0005220_abnormal_exocrine_pancreas0.49310248
103MP0000026_abnormal_inner_ear0.48915612
104MP0002572_abnormal_emotion/affect_behav0.46981488
105MP0005376_homeostasis/metabolism_phenot0.46337975
106MP0002751_abnormal_autonomic_nervous0.44947320
107MP0004859_abnormal_synaptic_plasticity0.44579546
108MP0009745_abnormal_behavioral_response0.44335042
109MP0001186_pigmentation_phenotype0.44193413
110MP0005448_abnormal_energy_balance0.43768238
111MP0004742_abnormal_vestibular_system0.43655218
112MP0009643_abnormal_urine_homeostasis0.43466369
113MP0000631_abnormal_neuroendocrine_gland0.43201636
114MP0005535_abnormal_body_temperature0.42599716
115MP0002063_abnormal_learning/memory/cond0.42332631
116MP0000015_abnormal_ear_pigmentation0.41044189
117MP0000465_gastrointestinal_hemorrhage0.40454666
118MP0004145_abnormal_muscle_electrophysio0.40136914
119MP0000383_abnormal_hair_follicle0.40051888
120MP0000372_irregular_coat_pigmentation0.40042101
121MP0001968_abnormal_touch/_nociception0.38646716
122MP0001905_abnormal_dopamine_level0.37254496
123MP0001188_hyperpigmentation0.36842588
124MP0004782_abnormal_surfactant_physiolog0.36203374
125MP0003045_fibrosis0.34692245
126MP0004142_abnormal_muscle_tone0.34618896
127MP0005595_abnormal_vascular_smooth0.32873500
128MP0005646_abnormal_pituitary_gland0.30715488
129MP0004043_abnormal_pH_regulation0.30329241
130MP0010386_abnormal_urinary_bladder0.30315162
131MP0005386_behavior/neurological_phenoty0.29089566
132MP0004924_abnormal_behavior0.29089566
133MP0004215_abnormal_myocardial_fiber0.26949936
134MP0004085_abnormal_heartbeat0.26817810
135MP0005409_darkened_coat_color0.25323407
136MP0001661_extended_life_span0.25317810
137MP0002184_abnormal_innervation0.24883064
138MP0002557_abnormal_social/conspecific_i0.24864318
139MP0008569_lethality_at_weaning0.24863665
140MP0005310_abnormal_salivary_gland0.24361949
141MP0003890_abnormal_embryonic-extraembry0.23717497
142MP0008004_abnormal_stomach_pH0.23399909
143MP0003646_muscle_fatigue0.23043469
144MP0005620_abnormal_muscle_contractility0.22969708
145MP0002066_abnormal_motor_capabilities/c0.22272573
146MP0005248_abnormal_Harderian_gland0.21420228
147MP0002152_abnormal_brain_morphology0.20338494
148MP0002697_abnormal_eye_size0.19964769
149MP0008058_abnormal_DNA_repair0.19500869
150MP0001501_abnormal_sleep_pattern0.18638336
151MP0005193_abnormal_anterior_eye0.17866738
152MP0000778_abnormal_nervous_system0.17186445
153MP0001970_abnormal_pain_threshold0.16545468
154MP0003787_abnormal_imprinting0.15971999
155MP0002928_abnormal_bile_duct0.15904151
156MP0004811_abnormal_neuron_physiology0.13346849
157MP0005076_abnormal_cell_differentiation0.12177073
158MP0008995_early_reproductive_senescence0.10611234
159MP0003632_abnormal_nervous_system0.10399703
160MP0003633_abnormal_nervous_system0.09675777
161MP0001177_atelectasis0.09077437
162MP0000751_myopathy0.08388005
163MP0004133_heterotaxia0.08022862
164MP0000001_mammalian_phenotype0.07758577
165MP0001440_abnormal_grooming_behavior0.07149722
166MP0003698_abnormal_male_reproductive0.07090189
167MP0003638_abnormal_response/metabolism_0.06430424

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)9.27944745
2Chorioretinal atrophy (HP:0000533)9.00178466
3Central scotoma (HP:0000603)7.99951960
4Attenuation of retinal blood vessels (HP:0007843)7.89257596
5Pendular nystagmus (HP:0012043)7.73226254
6Dyschromatopsia (HP:0007641)7.70757079
7Abnormality of macular pigmentation (HP:0008002)7.36648838
8Amelogenesis imperfecta (HP:0000705)7.26367799
9Scotoma (HP:0000575)7.19626383
10Abolished electroretinogram (ERG) (HP:0000550)6.68165496
11Focal motor seizures (HP:0011153)6.45557231
12Decreased central vision (HP:0007663)6.44016069
13* Photophobia (HP:0000613)5.56612473
14* Type II diabetes mellitus (HP:0005978)5.53920385
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.18488038
16Acanthocytosis (HP:0001927)5.12660711
17Keratoconus (HP:0000563)5.10500119
18Increased corneal curvature (HP:0100692)5.10500119
19Parakeratosis (HP:0001036)5.03389570
20Vitreoretinal degeneration (HP:0000655)4.98202006
21Macular degeneration (HP:0000608)4.96678459
22Abnormality of aromatic amino acid family metabolism (HP:0004338)4.88318617
23Cone-rod dystrophy (HP:0000548)4.82608283
24Severe visual impairment (HP:0001141)4.57868182
25Abnormality of monocarboxylic acid metabolism (HP:0010996)4.53357938
26Choroideremia (HP:0001139)4.39911383
27* Retinitis pigmentosa (HP:0000510)4.33388783
28Constricted visual fields (HP:0001133)4.27365633
29Posterior subcapsular cataract (HP:0007787)4.17317180
30Aplastic anemia (HP:0001915)3.90125783
31Decreased electroretinogram (ERG) amplitude (HP:0000654)3.63420224
32Abnormality of the renal cortex (HP:0011035)3.40524179
33Dialeptic seizures (HP:0011146)3.35030866
34Colon cancer (HP:0003003)3.32410482
35Progressive visual loss (HP:0000529)3.11041340
36Aplasia/Hypoplasia of the uvula (HP:0010293)3.09760650
37Rectal prolapse (HP:0002035)3.08856314
38Congenital ichthyosiform erythroderma (HP:0007431)3.05985330
39Potter facies (HP:0002009)3.05870058
40Facial shape deformation (HP:0011334)3.05870058
41Enlarged kidneys (HP:0000105)2.97886150
42Hyperglycinuria (HP:0003108)2.90665167
43Retinal atrophy (HP:0001105)2.86360231
44Proximal amyotrophy (HP:0007126)2.82768142
45Poikilocytosis (HP:0004447)2.79019720
46Prolonged partial thromboplastin time (HP:0003645)2.76739525
47Optic disc pallor (HP:0000543)2.73930141
48Erythroderma (HP:0001019)2.72373461
49Type I transferrin isoform profile (HP:0003642)2.63039306
50Abnormality of proline metabolism (HP:0010907)2.62732409
51Hydroxyprolinuria (HP:0003080)2.62732409
52Gait imbalance (HP:0002141)2.60811425
53Congenital sensorineural hearing impairment (HP:0008527)2.59367845
54Congenital primary aphakia (HP:0007707)2.59283192
55Abnormality of glutamine family amino acid metabolism (HP:0010902)2.56464789
56Abnormality of glycine metabolism (HP:0010895)2.55959737
57Abnormality of serine family amino acid metabolism (HP:0010894)2.55959737
58Focal seizures (HP:0007359)2.53867008
59Subcapsular cataract (HP:0000523)2.50527458
60* Wide nasal bridge (HP:0000431)2.46202364
61Hypobetalipoproteinemia (HP:0003563)2.45507051
62Tubular atrophy (HP:0000092)2.45118040
63Conjugated hyperbilirubinemia (HP:0002908)2.41308765
64Progressive inability to walk (HP:0002505)2.34426709
65Nephrogenic diabetes insipidus (HP:0009806)2.31162853
66Decreased circulating renin level (HP:0003351)2.30599647
67Medial flaring of the eyebrow (HP:0010747)2.30252861
68Opisthotonus (HP:0002179)2.29570446
69Hypokalemia (HP:0002900)2.27487637
70Hematochezia (HP:0002573)2.26148492
71Difficulty walking (HP:0002355)2.23562556
72Tubulointerstitial fibrosis (HP:0005576)2.21633795
73Ulnar claw (HP:0001178)2.17347766
74Abnormal albumin level (HP:0012116)2.14505111
75Hypoalbuminemia (HP:0003073)2.14505111
76Inability to walk (HP:0002540)2.13163995
77Epidermoid cyst (HP:0200040)2.11041226
78Overlapping toe (HP:0001845)2.10991748
79Hyperalaninemia (HP:0003348)2.05037415
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05037415
81Abnormality of alanine metabolism (HP:0010916)2.05037415
82Hyperglycinemia (HP:0002154)2.00058675
83Congenital stationary night blindness (HP:0007642)15.2042315
84Bony spicule pigmentary retinopathy (HP:0007737)12.0278503
85Absent rod-and cone-mediated responses on ERG (HP:0007688)10.6657997
86Abnormal rod and cone electroretinograms (HP:0008323)10.3891309
87Fair hair (HP:0002286)1.98878526
88Chronic diarrhea (HP:0002028)1.97864332
89Type II lissencephaly (HP:0007260)1.95677424
90Poor coordination (HP:0002370)1.94513665
91Glycosuria (HP:0003076)1.94366686
92Abnormality of urine glucose concentration (HP:0011016)1.94366686
93Abnormality of potassium homeostasis (HP:0011042)1.90027714
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89859545
95Abnormal protein N-linked glycosylation (HP:0012347)1.89859545
96Abnormal protein glycosylation (HP:0012346)1.89859545
97Abnormal glycosylation (HP:0012345)1.89859545
98Stomach cancer (HP:0012126)1.89020281
99Portal hypertension (HP:0001409)1.84661460
100Dehydration (HP:0001944)1.84405171
101True hermaphroditism (HP:0010459)1.83970612
102Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82123919
103Abnormal pancreas size (HP:0012094)1.81919791
104Vaginal atresia (HP:0000148)1.81497609
105Abnormality of the vocal cords (HP:0008777)1.80784569
106Tubulointerstitial abnormality (HP:0001969)1.80215089
107Vertebral arch anomaly (HP:0008438)1.78443373
108Gangrene (HP:0100758)1.75882523
109Spontaneous hematomas (HP:0007420)1.75399743
110Chromsome breakage (HP:0040012)1.74308466
111Genital tract atresia (HP:0001827)1.74239283
112Abnormality of pyrimidine metabolism (HP:0004353)1.72904129
113Hypoplastic iliac wings (HP:0002866)1.71818807
114Bile duct proliferation (HP:0001408)1.70423227
115Abnormal biliary tract physiology (HP:0012439)1.70423227
116Ileus (HP:0002595)1.68855134
117Abnormal drinking behavior (HP:0030082)1.68264381
118Polydipsia (HP:0001959)1.68264381
119Ketosis (HP:0001946)1.65323778
120Xanthomatosis (HP:0000991)1.64419646
121Bilateral sensorineural hearing impairment (HP:0008619)1.64252908
122Conjunctival telangiectasia (HP:0000524)1.63833678
123Abnormality of serum amino acid levels (HP:0003112)1.63468902
124Abnormality of the hepatic vasculature (HP:0006707)1.62311439
125* Optic atrophy (HP:0000648)1.60165037
126Pancreatic fibrosis (HP:0100732)1.57718739
127Aplasia/Hypoplasia of the lens (HP:0008063)1.54371810
128Horizontal nystagmus (HP:0000666)1.50233279
129Interstitial pulmonary disease (HP:0006530)1.49408928
130Polar cataract (HP:0010696)1.34754607
131Aplasia/Hypoplasia of the fovea (HP:0008060)1.31487991
132Hypoplasia of the fovea (HP:0007750)1.31487991
133Abnormality of the fovea (HP:0000493)1.31292615
134Pancreatic cysts (HP:0001737)1.30140706
135Astigmatism (HP:0000483)1.27741097
136Severe Myopia (HP:0011003)1.26306246
137Recurrent sinusitis (HP:0011108)1.26164865
138Cystic liver disease (HP:0006706)1.22971309
139Dysdiadochokinesis (HP:0002075)1.20912502
140Febrile seizures (HP:0002373)1.19534265
141Epileptic encephalopathy (HP:0200134)1.16184017
142Retinal detachment (HP:0000541)1.12327975
143Chorioretinal coloboma (HP:0000567)1.03898310
144Partial agenesis of the corpus callosum (HP:0001338)1.03454516
145Broad foot (HP:0001769)1.03252722
146Specific learning disability (HP:0001328)1.03220463
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.03200654
148Abnormality of midbrain morphology (HP:0002418)1.01836555
149Molar tooth sign on MRI (HP:0002419)1.01836555
150Left ventricular hypertrophy (HP:0001712)1.00169996
151Asthma (HP:0002099)1.00096027
152Decreased testicular size (HP:0008734)0.96621949
153Cerebellar dysplasia (HP:0007033)0.94732283
154Sclerocornea (HP:0000647)0.93332643
155Aplasia/Hypoplasia of the macula (HP:0008059)0.92910500
156Nephronophthisis (HP:0000090)0.91917487
157Abnormality of the renal medulla (HP:0100957)0.88532014
158Congenital hepatic fibrosis (HP:0002612)0.85386010
159Progressive cerebellar ataxia (HP:0002073)0.85096855
160Abnormality of dental color (HP:0011073)0.84557602
161Hypermetropia (HP:0000540)0.82636437
162Aplasia/Hypoplasia affecting the retina (HP:0008061)0.81843485
163Anencephaly (HP:0002323)0.81429319
164Postaxial hand polydactyly (HP:0001162)0.79965317
165Chronic hepatic failure (HP:0100626)0.79518917
166Furrowed tongue (HP:0000221)0.77471103
167Truncal ataxia (HP:0002078)0.74990494
168Dental crowding (HP:0000678)0.74578982
169Osteomalacia (HP:0002749)0.74398765
170Lymphopenia (HP:0001888)0.73802567
171Septo-optic dysplasia (HP:0100842)0.71557111
172Hypodontia (HP:0000668)0.70135863
173Short foot (HP:0001773)0.68770913
174Multicystic kidney dysplasia (HP:0000003)0.67313011
175Visual hallucinations (HP:0002367)0.67094799
176Postaxial foot polydactyly (HP:0001830)0.66857295
177Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.66799236
178Nephrotic syndrome (HP:0000100)0.65674056
179Abnormality of cells of the lymphoid lineage (HP:0012140)0.65622706
180Male pseudohermaphroditism (HP:0000037)0.65326134
181Tubulointerstitial nephritis (HP:0001970)0.63730592
182Broad-based gait (HP:0002136)0.62890507
183Preaxial hand polydactyly (HP:0001177)0.61466023

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK7.79022541
2STK38L6.71163002
3LATS25.39749569
4ZAK3.40467357
5ACVR1B3.26689820
6IRAK22.77235895
7PINK12.69917830
8NLK2.22850281
9BMPR1B2.18865682
10STK32.12847056
11GRK110.5014031
12MAP2K21.89381185
13SIK21.76506104
14TAOK31.71549482
15INSRR1.67409686
16MELK1.54873043
17MKNK21.48565391
18ADRBK11.46128300
19CAMK1G1.36958213
20MAPK71.36767601
21ADRBK21.32986176
22LMTK21.32921762
23CASK1.25146927
24CCNB11.22842095
25MAPK121.16445673
26CDK31.15178774
27HIPK21.11741473
28EIF2AK31.11049130
29BRD41.08244678
30PIK3CG1.07704554
31MAP3K101.07114535
32TAF11.06704731
33CAMK1D1.04014430
34SGK4941.03023737
35SGK2231.03023737
36MAP4K21.02800527
37NEK61.02713505
38MAP3K20.99199359
39PNCK0.98656846
40STK380.96124559
41CSNK1D0.95417470
42CDK120.94256202
43AKT30.93831912
44MARK10.92029643
45PRKCZ0.90125458
46TGFBR10.88166459
47TNIK0.87552644
48RPS6KA40.87027018
49PAK60.85653566
50SGK20.84742320
51WNK30.84667000
52BRSK20.81133199
53TLK10.81064177
54OXSR10.80505075
55ERBB20.78336391
56FES0.78268501
57PKN10.77140676
58BLK0.75934752
59DAPK20.73834826
60PRKAA20.71749574
61PDPK10.69988770
62CAMK2D0.69982504
63WNK10.69894453
64CSNK1A1L0.69701425
65DYRK1A0.69007362
66PRPF4B0.68238109
67PRKCH0.68051879
68PRKCB0.64114911
69STK160.63820387
70YES10.63632627
71PRKD20.63358233
72SGK30.63143880
73NTRK30.61012946
74TTK0.60218412
75MKNK10.59730288
76MAP2K70.59432020
77CAMK10.58577542
78MST40.58286691
79MAP3K40.58043171
80GRK70.57108830
81NME10.56600849
82CAMKK10.56491768
83PRKAA10.56184043
84PRKACG0.55820763
85GRK50.55500744
86CAMK2A0.53549404
87PRKD30.52870342
88ICK0.52511309
89RPS6KA30.51292771
90TNK20.50326581
91NEK10.49855619
92PLK20.49113068
93SGK10.47557308
94NUAK10.47467444
95MAPK130.44958594
96PRKD10.42512655
97GSK3B0.41650215
98OBSCN0.41366944
99PHKG20.41272017
100PHKG10.41272017
101PLK10.40544141
102PRKDC0.40037849
103MAP2K10.40019717
104PRKCG0.38742756
105MAPK140.38574326
106PRKCE0.37988810
107PRKACA0.37014736
108NEK90.36758009
109PRKCI0.36004498
110PIK3CA0.35743971
111MYLK0.34874989
112TGFBR20.34644998
113CDK90.34295757
114MAPKAPK30.33564675
115CDK50.32782493
116STK110.32501235
117STK390.32409788
118MAPK100.31724893
119NEK20.31710108
120MAPK90.31509694
121PDK20.31352725
122CHEK20.31278158
123CAMK40.30853044
124TXK0.29302931
125PRKCA0.29284272
126RPS6KB10.28567707
127PLK30.28364988
128FRK0.28255607
129RPS6KA50.27881527
130CDK10.27767647
131NTRK20.26763898
132MUSK0.26635908
133AKT20.26434052
134WEE10.26388709
135LATS10.26310975
136CHUK0.26303828
137WNK40.24658665
138IRAK10.24227398
139CDC42BPA0.23418193
140PRKG20.22819126
141FER0.22452302
142PRKG10.22441062
143KSR20.21995788
144BCKDK0.21883079
145BMPR20.21331394
146VRK10.21038125
147IRAK30.20480693
148PIM10.18628888
149PAK30.16900718
150STK100.15475563
151EIF2AK20.15401755
152EPHA40.15273763
153PRKCQ0.15127109
154IKBKB0.14769653
155PTK2B0.14149468
156TRIM280.13873395
157CSNK1A10.13659320
158ABL10.13386720
159TEC0.11889273
160VRK20.10309741
161MAP3K120.09691519
162IGF1R0.08353791
163CDK190.08236290
164PRKACB0.07363532
165MAPK30.06317173

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.41660231
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.80769751
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.72447746
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.62851080
5Butanoate metabolism_Homo sapiens_hsa006502.32770097
6Tryptophan metabolism_Homo sapiens_hsa003802.29663361
7Phenylalanine metabolism_Homo sapiens_hsa003602.26209084
8Steroid hormone biosynthesis_Homo sapiens_hsa001402.14370661
9Histidine metabolism_Homo sapiens_hsa003402.05829683
10Chemical carcinogenesis_Homo sapiens_hsa052042.04523464
11* Phototransduction_Homo sapiens_hsa0474415.9988519
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93540313
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88953430
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88917926
15Fatty acid degradation_Homo sapiens_hsa000711.85501420
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73992726
17Olfactory transduction_Homo sapiens_hsa047401.65556273
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.63037673
19Tyrosine metabolism_Homo sapiens_hsa003501.57382488
20Synaptic vesicle cycle_Homo sapiens_hsa047211.53260009
21beta-Alanine metabolism_Homo sapiens_hsa004101.46026097
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41104844
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36740554
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.35578534
25Bile secretion_Homo sapiens_hsa049761.30617878
26Propanoate metabolism_Homo sapiens_hsa006401.27462379
27Complement and coagulation cascades_Homo sapiens_hsa046101.23924793
28Peroxisome_Homo sapiens_hsa041461.22453662
29Dorso-ventral axis formation_Homo sapiens_hsa043201.21416159
30GABAergic synapse_Homo sapiens_hsa047271.20501066
31One carbon pool by folate_Homo sapiens_hsa006701.17498187
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07514387
33Starch and sucrose metabolism_Homo sapiens_hsa005001.05446900
34Arachidonic acid metabolism_Homo sapiens_hsa005901.03899409
35Retinol metabolism_Homo sapiens_hsa008300.98465026
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94967140
37N-Glycan biosynthesis_Homo sapiens_hsa005100.94177636
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94065353
39Cholinergic synapse_Homo sapiens_hsa047250.93759484
40Morphine addiction_Homo sapiens_hsa050320.93052440
41Sulfur relay system_Homo sapiens_hsa041220.91379539
42Fat digestion and absorption_Homo sapiens_hsa049750.90422618
43Glutamatergic synapse_Homo sapiens_hsa047240.86894326
44Pyruvate metabolism_Homo sapiens_hsa006200.86336881
45Arginine and proline metabolism_Homo sapiens_hsa003300.84650881
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83255281
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82901078
48Circadian entrainment_Homo sapiens_hsa047130.82771219
49Selenocompound metabolism_Homo sapiens_hsa004500.77888182
50Dopaminergic synapse_Homo sapiens_hsa047280.77487965
51Circadian rhythm_Homo sapiens_hsa047100.76424035
52Serotonergic synapse_Homo sapiens_hsa047260.76398269
53PPAR signaling pathway_Homo sapiens_hsa033200.71427716
54Metabolic pathways_Homo sapiens_hsa011000.64744521
55ABC transporters_Homo sapiens_hsa020100.62743103
56Sulfur metabolism_Homo sapiens_hsa009200.62546649
57Nicotine addiction_Homo sapiens_hsa050330.61764475
58Basal transcription factors_Homo sapiens_hsa030220.59613545
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59045923
60Insulin secretion_Homo sapiens_hsa049110.54883249
61Oxidative phosphorylation_Homo sapiens_hsa001900.54748780
62Homologous recombination_Homo sapiens_hsa034400.54590779
63Fatty acid metabolism_Homo sapiens_hsa012120.52913584
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46834599
65Purine metabolism_Homo sapiens_hsa002300.45757117
66Oxytocin signaling pathway_Homo sapiens_hsa049210.42928549
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42675142
68RNA polymerase_Homo sapiens_hsa030200.40043009
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38083668
70Nitrogen metabolism_Homo sapiens_hsa009100.37656436
71Fanconi anemia pathway_Homo sapiens_hsa034600.37474387
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37184172
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36687306
74Folate biosynthesis_Homo sapiens_hsa007900.36642300
75* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36320201
76Salivary secretion_Homo sapiens_hsa049700.35625394
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35088421
78Glutathione metabolism_Homo sapiens_hsa004800.35037513
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33647150
80Inositol phosphate metabolism_Homo sapiens_hsa005620.32976330
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31423702
82Chemokine signaling pathway_Homo sapiens_hsa040620.30690000
83Fatty acid biosynthesis_Homo sapiens_hsa000610.30451754
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30388160
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30346281
86Renin secretion_Homo sapiens_hsa049240.30302423
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28255828
88Fatty acid elongation_Homo sapiens_hsa000620.27971301
89Gastric acid secretion_Homo sapiens_hsa049710.27217349
90Cocaine addiction_Homo sapiens_hsa050300.27028006
91* cAMP signaling pathway_Homo sapiens_hsa040240.26377169
92Dilated cardiomyopathy_Homo sapiens_hsa054140.25894436
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25537633
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25037252
95Taste transduction_Homo sapiens_hsa047420.24304550
96Fructose and mannose metabolism_Homo sapiens_hsa000510.24247097
97Cardiac muscle contraction_Homo sapiens_hsa042600.23497660
98Glycerolipid metabolism_Homo sapiens_hsa005610.23310644
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23160642
100Calcium signaling pathway_Homo sapiens_hsa040200.22834767
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.21453258
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21379758
103Parkinsons disease_Homo sapiens_hsa050120.21076861
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.20475677
105Collecting duct acid secretion_Homo sapiens_hsa049660.19865513
106Long-term potentiation_Homo sapiens_hsa047200.19745126
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19684104
108Protein export_Homo sapiens_hsa030600.18595987
109Ras signaling pathway_Homo sapiens_hsa040140.18437052
110Alcoholism_Homo sapiens_hsa050340.18193812
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18059538
112Amphetamine addiction_Homo sapiens_hsa050310.17389723
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.17051802
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.16933887
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16789226
116Type II diabetes mellitus_Homo sapiens_hsa049300.16566689
117Caffeine metabolism_Homo sapiens_hsa002320.16554886
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15958989
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15934455
120Pancreatic secretion_Homo sapiens_hsa049720.15447256
121Lysine degradation_Homo sapiens_hsa003100.15293321
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15121209
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14649982
124Biosynthesis of amino acids_Homo sapiens_hsa012300.14383318
125Arginine biosynthesis_Homo sapiens_hsa002200.13047739
126mTOR signaling pathway_Homo sapiens_hsa041500.12661897
127Glucagon signaling pathway_Homo sapiens_hsa049220.12061912
128Linoleic acid metabolism_Homo sapiens_hsa005910.11547482
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.11287311
130Ether lipid metabolism_Homo sapiens_hsa005650.11269763
131Huntingtons disease_Homo sapiens_hsa050160.10327934
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10175236
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09226797
134Rheumatoid arthritis_Homo sapiens_hsa053230.09138822
135HIF-1 signaling pathway_Homo sapiens_hsa040660.09051419
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.08924176
137MAPK signaling pathway_Homo sapiens_hsa040100.08312070
138GnRH signaling pathway_Homo sapiens_hsa049120.08244893
139Mineral absorption_Homo sapiens_hsa049780.07835691
140Ovarian steroidogenesis_Homo sapiens_hsa049130.07410998
141Vitamin digestion and absorption_Homo sapiens_hsa049770.06947856
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06723475
143Wnt signaling pathway_Homo sapiens_hsa043100.06179423
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06087386
145Galactose metabolism_Homo sapiens_hsa000520.05415327
146mRNA surveillance pathway_Homo sapiens_hsa030150.05314967
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.05086961
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.04739255
149Tight junction_Homo sapiens_hsa045300.04539859
150AMPK signaling pathway_Homo sapiens_hsa041520.04406950
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.04289679
152TGF-beta signaling pathway_Homo sapiens_hsa043500.03614187
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.03570833
154Vibrio cholerae infection_Homo sapiens_hsa051100.03432534
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.03288739
156Choline metabolism in cancer_Homo sapiens_hsa052310.03073917
157Thyroid hormone synthesis_Homo sapiens_hsa049180.03060511
158Melanogenesis_Homo sapiens_hsa049160.02525640
159Sphingolipid metabolism_Homo sapiens_hsa006000.02177978

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