CNEP1R1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein that belongs to the Tmemb_18A family. A similar protein in yeast is a component of an endoplasmic reticulum-associated protein phosphatase complex and is thought to play a role in the synthesis of triacylglycerol. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.98417220
2regulation of spindle organization (GO:0090224)4.86388562
3metaphase plate congression (GO:0051310)4.76004605
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.70264443
5platelet dense granule organization (GO:0060155)4.52319192
6protein K11-linked deubiquitination (GO:0035871)4.37983644
7purine nucleobase biosynthetic process (GO:0009113)4.22276581
8attachment of spindle microtubules to kinetochore (GO:0008608)4.11401974
9establishment of chromosome localization (GO:0051303)4.09779070
10regulation of sister chromatid cohesion (GO:0007063)3.95538662
11regulation of mitotic spindle organization (GO:0060236)3.83365171
12protein localization to kinetochore (GO:0034501)3.82095264
13water-soluble vitamin biosynthetic process (GO:0042364)3.80021349
14histone-serine phosphorylation (GO:0035404)3.77600461
15DNA deamination (GO:0045006)3.76014917
16CENP-A containing nucleosome assembly (GO:0034080)3.73899430
17maturation of 5.8S rRNA (GO:0000460)3.71793093
18DNA double-strand break processing (GO:0000729)3.70945285
19meiotic chromosome segregation (GO:0045132)3.70464395
20L-fucose catabolic process (GO:0042355)3.70148562
21fucose catabolic process (GO:0019317)3.70148562
22L-fucose metabolic process (GO:0042354)3.70148562
23detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.67706593
24mitotic sister chromatid cohesion (GO:0007064)3.67491822
25regulation of exit from mitosis (GO:0007096)3.63125150
26spindle checkpoint (GO:0031577)3.59341429
27kinetochore organization (GO:0051383)3.53124213
28regulation of integrin-mediated signaling pathway (GO:2001044)3.43220847
29regulation of meiosis I (GO:0060631)3.43143345
30respiratory chain complex IV assembly (GO:0008535)3.42516169
31chromatin remodeling at centromere (GO:0031055)3.41450668
32protein neddylation (GO:0045116)3.39803669
33protein-cofactor linkage (GO:0018065)3.36838874
34mitotic sister chromatid segregation (GO:0000070)3.35819495
35regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35795437
36indolalkylamine catabolic process (GO:0046218)3.33259854
37tryptophan catabolic process (GO:0006569)3.33259854
38indole-containing compound catabolic process (GO:0042436)3.33259854
39regulation of chromosome segregation (GO:0051983)3.28767659
40protein localization to chromosome, centromeric region (GO:0071459)3.26443460
41anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26234675
42adenosine metabolic process (GO:0046085)3.25462850
43response to pheromone (GO:0019236)3.23830506
44RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.22372082
45nucleobase biosynthetic process (GO:0046112)3.19364159
46sister chromatid segregation (GO:0000819)3.18575103
47ribosome assembly (GO:0042255)3.18147675
48protein K6-linked ubiquitination (GO:0085020)3.18113365
49mitotic chromosome condensation (GO:0007076)3.17806050
50preassembly of GPI anchor in ER membrane (GO:0016254)3.17666348
51DNA replication-independent nucleosome organization (GO:0034724)3.12810925
52DNA replication-independent nucleosome assembly (GO:0006336)3.12810925
53signal peptide processing (GO:0006465)3.12130878
54protein deneddylation (GO:0000338)3.11756675
55C-terminal protein lipidation (GO:0006501)3.11630217
56negative regulation of mast cell activation (GO:0033004)3.11280332
57positive regulation of osteoblast proliferation (GO:0033690)3.08687997
58neural tube formation (GO:0001841)3.08078347
59kynurenine metabolic process (GO:0070189)3.07475933
60regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06709470
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06549738
62indolalkylamine metabolic process (GO:0006586)3.06263783
63chromosome segregation (GO:0007059)3.05107720
64histone exchange (GO:0043486)3.03819254
65mitotic spindle checkpoint (GO:0071174)3.01998068
66mitotic G2 DNA damage checkpoint (GO:0007095)3.01859515
67kinetochore assembly (GO:0051382)3.00460316
68rRNA catabolic process (GO:0016075)2.99930543
69RNA capping (GO:0036260)2.98803040
707-methylguanosine RNA capping (GO:0009452)2.98803040
71regulation of protein heterodimerization activity (GO:0043497)2.96116354
72negative regulation of neurotransmitter secretion (GO:0046929)2.95859576
73regulation of RNA export from nucleus (GO:0046831)2.94546384
74mitotic G2/M transition checkpoint (GO:0044818)2.94419322
75regulation of hexokinase activity (GO:1903299)2.92247674
76regulation of glucokinase activity (GO:0033131)2.92247674
77cellular ketone body metabolic process (GO:0046950)2.91066011
787-methylguanosine mRNA capping (GO:0006370)2.90155245
79C-terminal protein amino acid modification (GO:0018410)2.89480551
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.88389520
81recombinational repair (GO:0000725)2.87749323
82cullin deneddylation (GO:0010388)2.86621349
83double-strand break repair via homologous recombination (GO:0000724)2.86284810
84termination of RNA polymerase III transcription (GO:0006386)2.85984248
85transcription elongation from RNA polymerase III promoter (GO:0006385)2.85984248
86kidney morphogenesis (GO:0060993)2.85189763
87positive regulation of chromosome segregation (GO:0051984)2.84375243
88GPI anchor metabolic process (GO:0006505)2.83780967
89regulation of mitotic spindle checkpoint (GO:1903504)2.83568540
90regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83568540
91regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.82744097
92proline transport (GO:0015824)2.82627334
93G1 DNA damage checkpoint (GO:0044783)2.82414345
94regulation of establishment of cell polarity (GO:2000114)2.81569933
95replication fork processing (GO:0031297)2.81557244
96tryptophan metabolic process (GO:0006568)2.81426561
97proteasome assembly (GO:0043248)2.81264579
98prenylation (GO:0097354)2.81133454
99protein prenylation (GO:0018342)2.81133454
100regulation of mitochondrial translation (GO:0070129)2.80278924
101cytochrome complex assembly (GO:0017004)2.80223428
102regulation of RIG-I signaling pathway (GO:0039535)2.80057970
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80005368
104mitotic spindle assembly checkpoint (GO:0007094)2.77070286
105cell cycle G1/S phase transition (GO:0044843)2.75996101
106G1/S transition of mitotic cell cycle (GO:0000082)2.75996101
107reciprocal DNA recombination (GO:0035825)2.75668226
108reciprocal meiotic recombination (GO:0007131)2.75668226
109spindle assembly checkpoint (GO:0071173)2.75461183
110otic vesicle formation (GO:0030916)2.74838214
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74449707
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73845320
113protein localization to cilium (GO:0061512)2.73542619
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.72717494
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.72717494
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.72717494
117negative regulation of sister chromatid segregation (GO:0033046)2.72717494
118positive regulation of oligodendrocyte differentiation (GO:0048714)2.71882439
119dopamine transport (GO:0015872)2.71545774
120synapsis (GO:0007129)2.71142544
121positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.70640312
122regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.69466035
123N-terminal protein amino acid modification (GO:0031365)2.69258684
124protein K11-linked ubiquitination (GO:0070979)2.69048705
125photoreceptor cell maintenance (GO:0045494)2.68570560
126regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68020764
127male meiosis I (GO:0007141)2.67218779
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66822955
129positive regulation of ligase activity (GO:0051351)2.66657322
130folic acid-containing compound biosynthetic process (GO:0009396)2.66437544
131labyrinthine layer development (GO:0060711)2.65638632
132axon ensheathment in central nervous system (GO:0032291)2.65277448
133central nervous system myelination (GO:0022010)2.65277448
134COPI coating of Golgi vesicle (GO:0048205)2.64769412
135Golgi transport vesicle coating (GO:0048200)2.64769412
136ketone body metabolic process (GO:1902224)2.64457886
137adaptation of signaling pathway (GO:0023058)2.63979782
138positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.63625754
139mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.63625754
140negative regulation of chromosome segregation (GO:0051985)2.63292708
141regulation of somitogenesis (GO:0014807)2.62387898
142ER overload response (GO:0006983)2.59472543
143negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59118123
144negative regulation of ligase activity (GO:0051352)2.59118123
145positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.59003521
146UDP-N-acetylglucosamine metabolic process (GO:0006047)2.58311536
147lactate metabolic process (GO:0006089)2.57709206
148behavioral response to nicotine (GO:0035095)2.56214571
149inositol phosphate catabolic process (GO:0071545)2.56135488
150DNA replication checkpoint (GO:0000076)2.55587525
151keratinocyte development (GO:0003334)2.54686588
152regulation of MHC class II biosynthetic process (GO:0045346)2.54331924
153L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.54212673
154negative regulation of DNA-dependent DNA replication (GO:2000104)2.53609025
155anterograde synaptic vesicle transport (GO:0048490)2.53520626
156microtubule nucleation (GO:0007020)2.53231521
157regulation of DNA methylation (GO:0044030)2.52968503
158regulation of nuclear cell cycle DNA replication (GO:0033262)2.52714964
159protein localization to chromosome (GO:0034502)2.52192791
160negative regulation of telomere maintenance (GO:0032205)2.51878486
161mitotic nuclear envelope disassembly (GO:0007077)2.51681733
162sister chromatid cohesion (GO:0007062)2.51145003
163regulation of centrosome cycle (GO:0046605)2.50677348
164establishment of protein localization to mitochondrial membrane (GO:0090151)2.47896222
165positive regulation of mitochondrial fission (GO:0090141)2.47838476
166regulation of histone phosphorylation (GO:0033127)2.47592620
167cytidine deamination (GO:0009972)2.47463337
168cytidine metabolic process (GO:0046087)2.47463337
169cytidine catabolic process (GO:0006216)2.47463337
170auditory receptor cell stereocilium organization (GO:0060088)2.46765401
171transcription elongation from RNA polymerase II promoter (GO:0006368)2.45986872
172reflex (GO:0060004)2.44844892
173regulation of metalloenzyme activity (GO:0048552)2.44481619
174protein complex biogenesis (GO:0070271)2.43303760
175epithelial cilium movement (GO:0003351)2.43017229
176mitochondrial RNA metabolic process (GO:0000959)2.42786277
177mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.42584878
178mitochondrial respiratory chain complex I assembly (GO:0032981)2.42584878
179NADH dehydrogenase complex assembly (GO:0010257)2.42584878
180cilium morphogenesis (GO:0060271)2.42211737
181piRNA metabolic process (GO:0034587)2.41682006
182axoneme assembly (GO:0035082)2.40605984
183amine catabolic process (GO:0009310)2.40576187
184cellular biogenic amine catabolic process (GO:0042402)2.40576187
185ubiquinone biosynthetic process (GO:0006744)2.40552884
186positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.40204166
187tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.39599614
188RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.39599614
189somite development (GO:0061053)2.38005913
190somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.37724917
191somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.37724917
192isotype switching (GO:0045190)2.37724917
193mitochondrial respiratory chain complex assembly (GO:0033108)2.37426507
194mannosylation (GO:0097502)2.37417956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.12969908
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.99089850
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.87367216
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.87265291
5AR_21909140_ChIP-Seq_LNCAP_Human3.64133887
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.56779181
7ZNF274_21170338_ChIP-Seq_K562_Hela3.43534113
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.23412584
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.17454347
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13970436
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89216061
12VDR_22108803_ChIP-Seq_LS180_Human2.87540890
13ELK1_19687146_ChIP-ChIP_HELA_Human2.71620108
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71035617
15GBX2_23144817_ChIP-Seq_PC3_Human2.61572624
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.52125377
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.35737083
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34303269
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24682658
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.18994084
21P300_19829295_ChIP-Seq_ESCs_Human2.18845021
22IGF1R_20145208_ChIP-Seq_DFB_Human2.17196564
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11784741
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11207036
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05461433
26VDR_23849224_ChIP-Seq_CD4+_Human2.03296251
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02562723
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01655271
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.98294059
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95420727
31TAF15_26573619_Chip-Seq_HEK293_Human1.93893143
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.90902415
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90899070
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.90845397
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.89000504
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88088049
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86078529
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83616684
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81530242
40DCP1A_22483619_ChIP-Seq_HELA_Human1.79706669
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72023834
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71457049
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71244962
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70756422
45EWS_26573619_Chip-Seq_HEK293_Human1.68718891
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.67657253
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66430395
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.65279225
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.64254544
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64212163
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62845022
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.61966446
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61381442
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.60971402
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60155296
56GABP_19822575_ChIP-Seq_HepG2_Human1.58371995
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.56598482
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56274765
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56222388
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55354918
61BCAT_22108803_ChIP-Seq_LS180_Human1.55315413
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54487294
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53249767
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.52915447
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52260387
66SMAD4_21799915_ChIP-Seq_A2780_Human1.47348707
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39662578
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39494323
69CBP_20019798_ChIP-Seq_JUKART_Human1.39494323
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39436448
71NANOG_19829295_ChIP-Seq_ESCs_Human1.39430550
72SOX2_19829295_ChIP-Seq_ESCs_Human1.39430550
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.39279771
74FUS_26573619_Chip-Seq_HEK293_Human1.38507311
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.37629527
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.37527189
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37121946
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37044902
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36817190
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36103027
81EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35805822
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34744568
83CDX2_22108803_ChIP-Seq_LS180_Human1.34401242
84IRF1_19129219_ChIP-ChIP_H3396_Human1.33297863
85TP53_22573176_ChIP-Seq_HFKS_Human1.31043061
86MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30708240
87TFEB_21752829_ChIP-Seq_HELA_Human1.30600859
88AR_25329375_ChIP-Seq_VCAP_Human1.30549634
89STAT3_23295773_ChIP-Seq_U87_Human1.30293780
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30206401
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30206258
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30058222
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29501079
94* BRD4_25478319_ChIP-Seq_HGPS_Human1.28882370
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.28463897
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28081667
97P53_22387025_ChIP-Seq_ESCs_Mouse1.27954521
98TCF4_22108803_ChIP-Seq_LS180_Human1.27937651
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27396814
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27347546
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27114312
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27114312
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26179750
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.25929029
105FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25929029
106TCF4_23295773_ChIP-Seq_U87_Human1.25678560
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24437427
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23007205
109HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22681252
110FOXP3_21729870_ChIP-Seq_TREG_Human1.22009889
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.21914785
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21776431
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.20383718
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19883205
115MYC_18940864_ChIP-ChIP_HL60_Human1.18923868
116MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18314412
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.18182513
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.17891740
119MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17838441
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17704159
121ELK1_22589737_ChIP-Seq_MCF10A_Human1.16928843
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.16729469
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16706931
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16636753
125XRN2_22483619_ChIP-Seq_HELA_Human1.14992038
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14389215
127THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14140539
128P300_18555785_Chip-Seq_ESCs_Mouse1.13488819
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.13362899
130KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13338718
131OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12436997
132SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11674663
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11304765
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10736047
135RUNX2_22187159_ChIP-Seq_PCA_Human1.10174477
136KDM5A_27292631_Chip-Seq_BREAST_Human1.09637719
137SMAD4_21741376_ChIP-Seq_EPCs_Human1.09630097
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08152937
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08152937
140SOX17_20123909_ChIP-Seq_XEN_Mouse1.08092834
141WT1_19549856_ChIP-ChIP_CCG9911_Human1.07912754
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07801652
143FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07014388
144AR_20517297_ChIP-Seq_VCAP_Human1.06736768
145MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05449340
146EOMES_21245162_ChIP-Seq_HESCs_Human1.04528269
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03846794
148CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02641410
149OCT4_18555785_Chip-Seq_ESCs_Mouse1.02614171
150GATA3_26560356_Chip-Seq_TH2_Human1.02530557
151TRIM28_21343339_ChIP-Seq_HEK293_Human1.01976069
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01943926
153SOX2_18555785_Chip-Seq_ESCs_Mouse1.01335491
154TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00838634
155SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99882186
156ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99217199
157GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98433991
158NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98016723
159CJUN_26792858_Chip-Seq_BT549_Human0.97105493
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96440825
161CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96217272
162ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95022021
163MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94978904
164FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93982149
165NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93758259
166IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93128182
167ER_23166858_ChIP-Seq_MCF-7_Human0.92506050
168BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92457247
169HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92222033
170NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90335379
171SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90270395
172HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88113573
173EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87561277
174TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86849331
175PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86163439
176TTF2_22483619_ChIP-Seq_HELA_Human0.86071275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.84923227
2MP0006054_spinal_hemorrhage3.83744911
3MP0003950_abnormal_plasma_membrane3.36900013
4MP0008057_abnormal_DNA_replication3.22357514
5MP0003693_abnormal_embryo_hatching3.19899552
6MP0000569_abnormal_digit_pigmentation2.95701045
7MP0005503_abnormal_tendon_morphology2.87840353
8MP0008877_abnormal_DNA_methylation2.83383838
9MP0002837_dystrophic_cardiac_calcinosis2.69709584
10MP0004957_abnormal_blastocyst_morpholog2.60248595
11MP0008438_abnormal_cutaneous_collagen2.53729649
12MP0005084_abnormal_gallbladder_morpholo2.52668434
13MP0003787_abnormal_imprinting2.38880231
14MP0006072_abnormal_retinal_apoptosis2.33823963
15MP0003011_delayed_dark_adaptation2.21072950
16MP0003077_abnormal_cell_cycle2.16519328
17MP0005551_abnormal_eye_electrophysiolog2.15258640
18MP0001346_abnormal_lacrimal_gland2.10085544
19MP0008932_abnormal_embryonic_tissue2.06174812
20MP0005623_abnormal_meninges_morphology2.00036993
21MP0004145_abnormal_muscle_electrophysio1.96388730
22MP0005253_abnormal_eye_physiology1.95955112
23MP0004272_abnormal_basement_membrane1.95194230
24MP0003718_maternal_effect1.94946072
25MP0003656_abnormal_erythrocyte_physiolo1.90178029
26MP0003937_abnormal_limbs/digits/tail_de1.89971400
27MP0002277_abnormal_respiratory_mucosa1.89896223
28MP0003567_abnormal_fetal_cardiomyocyte1.85614395
29MP0000733_abnormal_muscle_development1.84399052
30MP0003646_muscle_fatigue1.81884397
31MP0003111_abnormal_nucleus_morphology1.79386581
32MP0002876_abnormal_thyroid_physiology1.78250104
33MP0003123_paternal_imprinting1.77802395
34MP0008058_abnormal_DNA_repair1.77097895
35MP0005174_abnormal_tail_pigmentation1.76462620
36MP0000015_abnormal_ear_pigmentation1.75680561
37MP0005367_renal/urinary_system_phenotyp1.73651571
38MP0000516_abnormal_urinary_system1.73651571
39MP0005248_abnormal_Harderian_gland1.70791850
40MP0008007_abnormal_cellular_replicative1.66727724
41MP0004084_abnormal_cardiac_muscle1.66518915
42MP0002877_abnormal_melanocyte_morpholog1.61901659
43MP0008775_abnormal_heart_ventricle1.61644902
44MP0003186_abnormal_redox_activity1.60191118
45MP0005645_abnormal_hypothalamus_physiol1.59909813
46MP0001299_abnormal_eye_distance/1.58035160
47MP0005075_abnormal_melanosome_morpholog1.57951516
48MP0005085_abnormal_gallbladder_physiolo1.56860169
49MP0001661_extended_life_span1.55109180
50MP0002928_abnormal_bile_duct1.54200266
51MP0001730_embryonic_growth_arrest1.52016092
52MP0000427_abnormal_hair_cycle1.51514389
53MP0004147_increased_porphyrin_level1.50347191
54MP0001986_abnormal_taste_sensitivity1.49082600
55MP0008872_abnormal_physiological_respon1.49015027
56MP0000747_muscle_weakness1.47047054
57MP0003121_genomic_imprinting1.44409872
58MP0001697_abnormal_embryo_size1.40724347
59MP0003252_abnormal_bile_duct1.40718743
60MP0000920_abnormal_myelination1.40310487
61MP0008875_abnormal_xenobiotic_pharmacok1.39421005
62MP0009046_muscle_twitch1.38869831
63MP0009764_decreased_sensitivity_to1.36224624
64MP0009745_abnormal_behavioral_response1.35586298
65MP0003136_yellow_coat_color1.35266900
66MP0003806_abnormal_nucleotide_metabolis1.33785291
67MP0002638_abnormal_pupillary_reflex1.33600640
68MP0002254_reproductive_system_inflammat1.32319191
69MP0005167_abnormal_blood-brain_barrier1.31454457
70MP0005646_abnormal_pituitary_gland1.30530399
71MP0001529_abnormal_vocalization1.29196009
72MP0000350_abnormal_cell_proliferation1.28706270
73MP0010094_abnormal_chromosome_stability1.27147872
74MP0000631_abnormal_neuroendocrine_gland1.26634523
75MP0004142_abnormal_muscle_tone1.25924415
76MP0006138_congestive_heart_failure1.25809066
77MP0002282_abnormal_trachea_morphology1.25667938
78MP0002090_abnormal_vision1.24641877
79MP0001485_abnormal_pinna_reflex1.23640836
80MP0009250_abnormal_appendicular_skeleto1.23123629
81MP0002751_abnormal_autonomic_nervous1.22967624
82MP0005076_abnormal_cell_differentiation1.22871076
83MP0004036_abnormal_muscle_relaxation1.20558503
84MP0009384_cardiac_valve_regurgitation1.20491856
85MP0010307_abnormal_tumor_latency1.20461045
86MP0005508_abnormal_skeleton_morphology1.20236837
87MP0001764_abnormal_homeostasis1.19764465
88MP0002163_abnormal_gland_morphology1.19486838
89MP0009333_abnormal_splenocyte_physiolog1.19365492
90MP0005379_endocrine/exocrine_gland_phen1.16978524
91MP0005408_hypopigmentation1.16171380
92MP0001324_abnormal_eye_pigmentation1.14976975
93MP0005058_abnormal_lysosome_morphology1.14515194
94MP0003984_embryonic_growth_retardation1.13800760
95MP0005380_embryogenesis_phenotype1.13174637
96MP0001672_abnormal_embryogenesis/_devel1.13174637
97MP0002106_abnormal_muscle_physiology1.13168839
98MP0009697_abnormal_copulation1.12866308
99MP0005389_reproductive_system_phenotype1.12434018
100MP0002088_abnormal_embryonic_growth/wei1.11797417
101MP0001501_abnormal_sleep_pattern1.11175468
102MP0006036_abnormal_mitochondrial_physio1.11029644
103MP0003880_abnormal_central_pattern1.09820374
104MP0002693_abnormal_pancreas_physiology1.09715782
105MP0006082_CNS_inflammation1.08773448
106MP0004134_abnormal_chest_morphology1.07778020
107MP0001968_abnormal_touch/_nociception1.07565616
108MP0005369_muscle_phenotype1.07055453
109MP0001915_intracranial_hemorrhage1.05881730
110MP0001984_abnormal_olfaction1.05065269
111MP0002736_abnormal_nociception_after1.04768813
112MP0004197_abnormal_fetal_growth/weight/1.03616182
113MP0004133_heterotaxia1.02552499
114MP0003724_increased_susceptibility_to1.01844588
115MP0000750_abnormal_muscle_regeneration1.01190494
116MP0006035_abnormal_mitochondrial_morpho1.00773074
117MP0009785_altered_susceptibility_to1.00638089
118MP0005671_abnormal_response_to1.00216007
119MP0004215_abnormal_myocardial_fiber0.98819006
120MP0002085_abnormal_embryonic_tissue0.98374877
121MP0002160_abnormal_reproductive_system0.98345914
122MP0002938_white_spotting0.97925221
123MP0001835_abnormal_antigen_presentation0.97559973
124MP0002272_abnormal_nervous_system0.97002550
125MP0001486_abnormal_startle_reflex0.96973002
126MP0010386_abnormal_urinary_bladder0.96818475
127MP0002095_abnormal_skin_pigmentation0.96704255
128MP0003221_abnormal_cardiomyocyte_apopto0.96436006
129MP0001919_abnormal_reproductive_system0.96318958
130MP0001533_abnormal_skeleton_physiology0.95166584
131MP0005390_skeleton_phenotype0.93809234
132MP0002080_prenatal_lethality0.93648767
133MP0005332_abnormal_amino_acid0.93200710
134MP0001879_abnormal_lymphatic_vessel0.93090219
135MP0002084_abnormal_developmental_patter0.92998540
136MP0003448_altered_tumor_morphology0.92966851
137MP0002148_abnormal_hypersensitivity_rea0.92627193
138MP0000749_muscle_degeneration0.91064667
139MP0003137_abnormal_impulse_conducting0.90324632
140MP0005410_abnormal_fertilization0.90240125
141MP0002115_abnormal_skeleton_extremities0.89565257
142MP0000372_irregular_coat_pigmentation0.89507132
143MP0005621_abnormal_cell_physiology0.89386486
144MP0003786_premature_aging0.89105801
145MP0003755_abnormal_palate_morphology0.89074654
146MP0006292_abnormal_olfactory_placode0.88494829
147MP0004484_altered_response_of0.88391715
148MP0002113_abnormal_skeleton_development0.88277391
149MP0002138_abnormal_hepatobiliary_system0.88220191
150MP0005195_abnormal_posterior_eye0.88110549
151MP0001177_atelectasis0.86755263
152MP0000163_abnormal_cartilage_morphology0.86114353
153MP0002086_abnormal_extraembryonic_tissu0.84903163
154MP0010678_abnormal_skin_adnexa0.84418925
155MP0001851_eye_inflammation0.84118011
156MP0000428_abnormal_craniofacial_morphol0.84048398
157MP0006276_abnormal_autonomic_nervous0.83100897
158MP0000759_abnormal_skeletal_muscle0.82593112
159MP0004808_abnormal_hematopoietic_stem0.82080014
160MP0001905_abnormal_dopamine_level0.81677391
161MP0003195_calcinosis0.81611661
162MP0001119_abnormal_female_reproductive0.81570628
163MP0000647_abnormal_sebaceous_gland0.81229227
164MP0003828_pulmonary_edema0.79141544
165MP0005365_abnormal_bile_salt0.78801004
166MP0005384_cellular_phenotype0.78533985
167MP0004043_abnormal_pH_regulation0.77716936
168MP0002229_neurodegeneration0.77492583
169MP0005395_other_phenotype0.76355505
170MP0001929_abnormal_gametogenesis0.75758489
171MP0002127_abnormal_cardiovascular_syste0.75685308
172MP0005385_cardiovascular_system_phenoty0.75434762
173MP0001544_abnormal_cardiovascular_syste0.75434762
174MP0005266_abnormal_metabolism0.75286157
175MP0002896_abnormal_bone_mineralization0.75132803
176MP0002933_joint_inflammation0.75104825
177MP0005310_abnormal_salivary_gland0.73294902
178MP0001970_abnormal_pain_threshold0.72930654
179MP0005171_absent_coat_pigmentation0.72809233
180MP0008260_abnormal_autophagy0.72695080
181MP0003091_abnormal_cell_migration0.72359338
182MP0003122_maternal_imprinting0.71693432

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)5.22826962
2Birth length less than 3rd percentile (HP:0003561)4.70576866
3Hypoplastic ischia (HP:0003175)4.55149048
4Pancreatic cysts (HP:0001737)3.95796192
5Abnormality of the ischium (HP:0003174)3.82068292
6Breast hypoplasia (HP:0003187)3.80198696
7Flat capital femoral epiphysis (HP:0003370)3.74197959
8Microglossia (HP:0000171)3.72125810
9True hermaphroditism (HP:0010459)3.71757360
10Molar tooth sign on MRI (HP:0002419)3.30745851
11Abnormality of midbrain morphology (HP:0002418)3.30745851
12Progressive inability to walk (HP:0002505)3.27803217
13Muscle fiber splitting (HP:0003555)3.27349461
14Epiphyseal dysplasia (HP:0002656)3.18356220
15Vitreoretinal degeneration (HP:0000655)3.15699734
16Exercise-induced muscle cramps (HP:0003710)3.14072375
17Round ear (HP:0100830)3.13747684
18Absent epiphyses (HP:0010577)3.08597811
19Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.08597811
20Premature rupture of membranes (HP:0001788)3.04934843
21Stomatitis (HP:0010280)3.04612835
22Nephronophthisis (HP:0000090)2.99461268
23Fibular aplasia (HP:0002990)2.95918077
24Ankle contracture (HP:0006466)2.95693867
25Type II lissencephaly (HP:0007260)2.94101554
26Congenital stationary night blindness (HP:0007642)2.90338746
27Medial flaring of the eyebrow (HP:0010747)2.88515798
28Abolished electroretinogram (ERG) (HP:0000550)2.88469218
29Wrist flexion contracture (HP:0001239)2.87845058
30Abnormality of the umbilical cord (HP:0010881)2.75581103
31Small epiphyses (HP:0010585)2.73465082
32Abnormality of the renal cortex (HP:0011035)2.72760244
33Abnormality of the labia minora (HP:0012880)2.72716433
34Abnormality of the fetal cardiovascular system (HP:0010948)2.69827822
35Abnormal umbilical cord blood vessels (HP:0011403)2.69827822
36Single umbilical artery (HP:0001195)2.69827822
37Abnormality of incisor morphology (HP:0011063)2.69585261
38Calcaneovalgus deformity (HP:0001848)2.68139360
39Abnormality of the proximal phalanges of the hand (HP:0009834)2.67399696
403-Methylglutaconic aciduria (HP:0003535)2.66222764
41Long clavicles (HP:0000890)2.65294106
42Albinism (HP:0001022)2.62978129
43Deformed tarsal bones (HP:0008119)2.61521474
44Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.59380296
45Methylmalonic acidemia (HP:0002912)2.56102016
46Glossoptosis (HP:0000162)2.54268146
47Male pseudohermaphroditism (HP:0000037)2.53781465
48Abnormal rod and cone electroretinograms (HP:0008323)2.53382253
49Inability to walk (HP:0002540)2.53205219
50Metaphyseal dysplasia (HP:0100255)2.52954918
51Nemaline bodies (HP:0003798)2.52935915
52Hypoplasia of the capital femoral epiphysis (HP:0003090)2.52124661
53Abnormality of the renal medulla (HP:0100957)2.51225510
54Cerebral hypomyelination (HP:0006808)2.49494498
55Cervical subluxation (HP:0003308)2.48982889
56Delayed epiphyseal ossification (HP:0002663)2.48716078
57Progressive macrocephaly (HP:0004481)2.47934110
58Sparse lateral eyebrow (HP:0005338)2.46461692
59Muscle fiber inclusion bodies (HP:0100299)2.46379941
60Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.46324232
61Protrusio acetabuli (HP:0003179)2.46145651
62Carpal bone hypoplasia (HP:0001498)2.45045788
63Attenuation of retinal blood vessels (HP:0007843)2.42241730
64Abnormality of the calcaneus (HP:0008364)2.37955922
65Acute necrotizing encephalopathy (HP:0006965)2.32212411
66Intestinal atresia (HP:0011100)2.32013898
67Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.30997487
68Abnormality of femoral epiphyses (HP:0006499)2.30997487
69Thyroiditis (HP:0100646)2.30757934
70Sensory axonal neuropathy (HP:0003390)2.30756367
71Abnormality of the phalanges of the 2nd finger (HP:0009541)2.29809193
72Absent radius (HP:0003974)2.29383697
73Postnatal microcephaly (HP:0005484)2.27640286
74Abnormality of the femoral head (HP:0003368)2.27203333
75Chronic hepatic failure (HP:0100626)2.26372512
76Cupped ribs (HP:0000887)2.25437583
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.24372605
78Wormian bones (HP:0002645)2.23964614
79Renal cortical cysts (HP:0000803)2.22334827
80Polydipsia (HP:0001959)2.20651467
81Abnormal drinking behavior (HP:0030082)2.20651467
82Furrowed tongue (HP:0000221)2.19675466
83Pendular nystagmus (HP:0012043)2.18680179
84Osteolytic defects of the hand bones (HP:0009699)2.18366279
85Osteolytic defects of the phalanges of the hand (HP:0009771)2.18366279
86Abnormal biliary tract physiology (HP:0012439)2.17234230
87Bile duct proliferation (HP:0001408)2.17234230
88Abnormality of the epiphysis of the femoral head (HP:0010574)2.15944661
89Increased CSF lactate (HP:0002490)2.15234615
90Shallow orbits (HP:0000586)2.13218960
91Ketoacidosis (HP:0001993)2.12872669
92Abnormality of alanine metabolism (HP:0010916)2.12435604
93Hyperalaninemia (HP:0003348)2.12435604
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12435604
95Aplasia/Hypoplasia of the tibia (HP:0005772)2.12355877
96Aplasia/Hypoplasia of the uvula (HP:0010293)2.12034790
97Decreased central vision (HP:0007663)2.11651552
98Aplasia/Hypoplasia of the fibula (HP:0006492)2.11605296
99Congenital, generalized hypertrichosis (HP:0004540)2.11398519
100Mitochondrial inheritance (HP:0001427)2.10833749
101Tubular atrophy (HP:0000092)2.09944097
102Absent phalangeal crease (HP:0006109)2.09212858
103Short clavicles (HP:0000894)2.07894592
104Biliary tract neoplasm (HP:0100574)2.06507103
105Increased serum pyruvate (HP:0003542)2.05385337
106Abnormality of glycolysis (HP:0004366)2.05385337
107Gaze-evoked nystagmus (HP:0000640)2.05092484
108Cystic liver disease (HP:0006706)2.03586369
109Hypoproteinemia (HP:0003075)2.03528885
110Optic nerve hypoplasia (HP:0000609)2.02954465
111Coxa vara (HP:0002812)2.02716299
112Methylmalonic aciduria (HP:0012120)2.02151212
113Stillbirth (HP:0003826)2.02137494
114Absent forearm bone (HP:0003953)2.01647627
115Aplasia involving forearm bones (HP:0009822)2.01647627
116Acute encephalopathy (HP:0006846)2.00809913
117Sclerocornea (HP:0000647)1.99813580
118Congenital primary aphakia (HP:0007707)1.98006911
119Vascular tortuosity (HP:0004948)1.97119895
120Disproportionate short-trunk short stature (HP:0003521)1.96047291
121Cerebellar dysplasia (HP:0007033)1.95894686
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95639288
123Fair hair (HP:0002286)1.94732074
124Septo-optic dysplasia (HP:0100842)1.94724799
125Congenital sensorineural hearing impairment (HP:0008527)1.94510016
126Neonatal respiratory distress (HP:0002643)1.93845493
127Irregular vertebral endplates (HP:0003301)1.93731068
128Meckel diverticulum (HP:0002245)1.93010291
129Abnormality of chromosome stability (HP:0003220)1.92970381
130Type 1 muscle fiber predominance (HP:0003803)1.92872487
131Spastic paraparesis (HP:0002313)1.92031493
132Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.91795917
133Constricted visual fields (HP:0001133)1.91726716
134Keratoconus (HP:0000563)1.90802703
135Increased corneal curvature (HP:0100692)1.90802703
136Gait imbalance (HP:0002141)1.90353752
137Global brain atrophy (HP:0002283)1.89661552
138Abnormality of the ileum (HP:0001549)1.89144308
139Bell-shaped thorax (HP:0001591)1.88913285
140Relative macrocephaly (HP:0004482)1.88309824
141Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87759975
142Short tibia (HP:0005736)1.86847176
143Hemiparesis (HP:0001269)1.86004896
144Autoamputation (HP:0001218)1.85881402
145Genital tract atresia (HP:0001827)1.85454487
146Congenital hepatic fibrosis (HP:0002612)1.85348095
147Hepatocellular necrosis (HP:0001404)1.84775390
148Hepatic necrosis (HP:0002605)1.82721917
149Aplasia/Hypoplasia of the fovea (HP:0008060)1.81433171
150Hypoplasia of the fovea (HP:0007750)1.81433171
151Abnormal biliary tract morphology (HP:0012440)1.81376798
152Abnormality of vitamin B metabolism (HP:0004340)1.80760215
153Barrel-shaped chest (HP:0001552)1.80109414
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80104112
155Absent hand (HP:0004050)1.79932977
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.79728936
157Genu varum (HP:0002970)1.79031600
158Nephrogenic diabetes insipidus (HP:0009806)1.78960639
159Hip contracture (HP:0003273)1.78329670
160Beaking of vertebral bodies (HP:0004568)1.76978136
161Segmental peripheral demyelination/remyelination (HP:0003481)1.76359629
162Vertebral compression fractures (HP:0002953)1.76305468
163Abnormal auditory evoked potentials (HP:0006958)1.76071879
164Delayed gross motor development (HP:0002194)1.75982562
165Short palpebral fissure (HP:0012745)1.75699294
166Patellar aplasia (HP:0006443)1.75545067
167Hypothermia (HP:0002045)1.74862260
168Lissencephaly (HP:0001339)1.74540724
169Abnormality of the vertebral endplates (HP:0005106)1.74468206
170Type 2 muscle fiber atrophy (HP:0003554)1.74375317
171Retinal dysplasia (HP:0007973)1.73088411
172Sloping forehead (HP:0000340)1.73063988
173Abnormal mitochondria in muscle tissue (HP:0008316)1.72567569
174Dandy-Walker malformation (HP:0001305)1.72153916
175Polyuria (HP:0000103)1.71526575
176Postaxial foot polydactyly (HP:0001830)1.70873349
177Anencephaly (HP:0002323)1.70304400
178Abnormality of methionine metabolism (HP:0010901)1.69802060
179CNS hypomyelination (HP:0003429)1.69642407
180Rough bone trabeculation (HP:0100670)1.68480499
181Aplasia/Hypoplasia of the patella (HP:0006498)1.68239210
182Hypomagnesemia (HP:0002917)1.67834690
183Abnormality of the fovea (HP:0000493)1.67703278
184Stomach cancer (HP:0012126)1.66848820
185Poor head control (HP:0002421)1.66556597
186Adrenal hypoplasia (HP:0000835)1.65528195
187Abnormal cartilage morphology (HP:0002763)1.65349435
188Hyperventilation (HP:0002883)1.65010439
189Exostoses (HP:0100777)1.64848698
190Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.64617810
191Degeneration of the lateral corticospinal tracts (HP:0002314)1.64617810
192Flattened epiphyses (HP:0003071)1.64139569
193Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.63313704
194Pancreatic fibrosis (HP:0100732)1.63041884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.71533736
2BRSK23.47564670
3WNK33.40545137
4EIF2AK13.00110260
5PBK2.91688198
6MAP4K22.77546226
7WEE12.70786015
8BMPR1B2.70331940
9TRIM282.63948187
10INSRR2.61660739
11LATS12.52139156
12NUAK12.45200524
13ACVR1B2.33028140
14STK32.18765946
15NEK22.17046247
16SCYL22.16961457
17BCR2.10383386
18ERBB32.07789959
19NEK12.06715874
20RPS6KA42.05165215
21MET1.97914609
22EIF2AK31.97386503
23MUSK1.93963667
24CDC71.82954020
25ADRBK21.81812079
26TXK1.75051511
27PLK31.71624597
28TAOK31.71326176
29SRPK11.68472910
30STK391.58249645
31GRK11.58145247
32ARAF1.51748533
33BRAF1.51660674
34PLK41.48805295
35AKT31.46295114
36MAPKAPK51.45485685
37MKNK11.43434523
38CSNK1G11.42881408
39NEK91.42036179
40STK241.41921518
41TNIK1.40667581
42CSNK1G31.31161468
43LIMK11.30417524
44CSNK1A1L1.30397059
45ABL21.30355522
46DYRK31.28358012
47PNCK1.27393374
48BLK1.24373379
49EPHA21.24209195
50MAPK131.23142013
51PINK11.23040759
52MAP3K41.21638119
53CHEK21.18797045
54KSR21.16978140
55DAPK21.14689547
56FGFR21.13069729
57DYRK21.10952181
58PLK21.10225178
59TTK1.08655063
60LATS21.08502730
61CAMKK21.03723976
62PLK11.03046098
63OXSR11.02388200
64CASK1.01831036
65STK38L1.00767015
66TESK20.99972561
67TTN0.99541508
68CSNK1G20.98659133
69BMPR20.96616349
70OBSCN0.96597579
71PIK3CG0.96352105
72KSR10.96331032
73BRSK10.95647986
74AURKB0.94528448
75PRKCE0.93208354
76IRAK10.92873226
77MOS0.91636595
78MST40.91053270
79MAP3K130.90641422
80STK40.88091490
81MAP3K80.87595554
82FER0.87355260
83SIK30.84440518
84MAP3K90.81469868
85VRK10.79998194
86DDR20.79456711
87STK100.70342407
88MAP2K30.69205387
89CHEK10.68896448
90STK160.68298850
91SGK2230.67277786
92SGK4940.67277786
93PAK40.67242583
94WNK40.66554800
95TSSK60.66404439
96ADRBK10.65920415
97MAP2K70.64503699
98MAP3K120.64026903
99ZAK0.63688183
100PRKCG0.63384926
101IKBKB0.61781632
102PIM20.61420009
103TLK10.60835777
104TEC0.60736553
105ERBB40.59164712
106NLK0.58956423
107PAK10.58899410
108LRRK20.58623863
109PAK30.57937153
110CDK60.56366522
111MKNK20.55805275
112MAP2K60.55461800
113PRKCQ0.55415441
114EPHA30.54717991
115MELK0.54609409
116NEK60.53851957
117NME10.52364781
118RAF10.52160632
119TRPM70.51893399
120TGFBR10.50684400
121AURKA0.49211829
122TAF10.48202987
123SGK30.47458637
124NME20.47163118
125MARK30.46602503
126EPHA40.45604289
127GRK70.45568503
128SGK20.44863953
129CDK40.44409586
130ATM0.44238782
131CDK140.43785326
132MAP3K30.43608118
133MAP3K50.43323191
134CDK190.40431682
135FRK0.39137992
136PRKCI0.38944347
137JAK30.37887671
138CAMK2A0.37152005
139YES10.35060858
140EIF2AK20.34655668
141PHKG20.34207473
142PHKG10.34207473
143LYN0.33591509
144CDK10.33015912
145MINK10.32235065
146PTK2B0.32231210
147CSNK1A10.31947783
148KDR0.31929546
149ABL10.31189426
150CCNB10.30932197
151PRKG10.26907652
152MAPKAPK30.25822798
153IGF1R0.25413483
154FLT30.25049226
155PRKACA0.24873907
156PRKACB0.23780142

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.89968352
2RNA polymerase_Homo sapiens_hsa030203.63341928
3Vitamin B6 metabolism_Homo sapiens_hsa007503.57357703
4Proteasome_Homo sapiens_hsa030503.45540821
5Cell cycle_Homo sapiens_hsa041103.09255360
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.04937853
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54527241
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.52372141
9Butanoate metabolism_Homo sapiens_hsa006502.43726734
10Basal transcription factors_Homo sapiens_hsa030222.30709317
11Propanoate metabolism_Homo sapiens_hsa006402.24810703
12Selenocompound metabolism_Homo sapiens_hsa004502.24107570
13Folate biosynthesis_Homo sapiens_hsa007902.17931636
14RNA transport_Homo sapiens_hsa030132.16522435
15Phototransduction_Homo sapiens_hsa047442.15112973
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.11555311
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09919462
18DNA replication_Homo sapiens_hsa030302.03602757
19Homologous recombination_Homo sapiens_hsa034401.89028545
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82801340
21Caffeine metabolism_Homo sapiens_hsa002321.80612972
22Tryptophan metabolism_Homo sapiens_hsa003801.67764266
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66889958
24Linoleic acid metabolism_Homo sapiens_hsa005911.65534781
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.63025993
26Nucleotide excision repair_Homo sapiens_hsa034201.60425592
27p53 signaling pathway_Homo sapiens_hsa041151.60400060
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53314715
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52635071
30Steroid biosynthesis_Homo sapiens_hsa001001.52505173
31Base excision repair_Homo sapiens_hsa034101.51701724
32Oocyte meiosis_Homo sapiens_hsa041141.50261730
33Spliceosome_Homo sapiens_hsa030401.49962539
34Renal cell carcinoma_Homo sapiens_hsa052111.47305028
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44209082
36Pyrimidine metabolism_Homo sapiens_hsa002401.42037961
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40916977
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35178490
39TGF-beta signaling pathway_Homo sapiens_hsa043501.32397146
40RNA degradation_Homo sapiens_hsa030181.30876986
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28891191
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27698055
43Nitrogen metabolism_Homo sapiens_hsa009101.24400041
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23158012
45Mismatch repair_Homo sapiens_hsa034301.21897075
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.20737592
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20447919
48Rheumatoid arthritis_Homo sapiens_hsa053231.17914216
49Shigellosis_Homo sapiens_hsa051311.16263714
50Fanconi anemia pathway_Homo sapiens_hsa034601.16203299
51Oxidative phosphorylation_Homo sapiens_hsa001901.15601973
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13734774
53ECM-receptor interaction_Homo sapiens_hsa045121.13582706
54Peroxisome_Homo sapiens_hsa041461.11650286
55Non-homologous end-joining_Homo sapiens_hsa034501.09963046
56Phagosome_Homo sapiens_hsa041451.06361702
57Epstein-Barr virus infection_Homo sapiens_hsa051691.04638523
58Vibrio cholerae infection_Homo sapiens_hsa051101.04200030
59Fatty acid degradation_Homo sapiens_hsa000711.01018169
60Type I diabetes mellitus_Homo sapiens_hsa049400.99083414
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97280434
62Ether lipid metabolism_Homo sapiens_hsa005650.96522398
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96325338
64Purine metabolism_Homo sapiens_hsa002300.94586337
65Fatty acid elongation_Homo sapiens_hsa000620.93398851
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89096020
67Parkinsons disease_Homo sapiens_hsa050120.88049795
68Small cell lung cancer_Homo sapiens_hsa052220.85255551
69Sphingolipid metabolism_Homo sapiens_hsa006000.84925211
70MicroRNAs in cancer_Homo sapiens_hsa052060.84833341
71Huntingtons disease_Homo sapiens_hsa050160.83856244
72Regulation of autophagy_Homo sapiens_hsa041400.81671969
73Prostate cancer_Homo sapiens_hsa052150.80888705
74Asthma_Homo sapiens_hsa053100.79741790
75Focal adhesion_Homo sapiens_hsa045100.79038954
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76298759
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76041706
78ABC transporters_Homo sapiens_hsa020100.75946411
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.75225139
80Circadian rhythm_Homo sapiens_hsa047100.75018114
81Malaria_Homo sapiens_hsa051440.74759815
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74681775
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74533121
84Taste transduction_Homo sapiens_hsa047420.72778935
85Sulfur metabolism_Homo sapiens_hsa009200.72757013
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71639372
87Viral carcinogenesis_Homo sapiens_hsa052030.71350388
88Olfactory transduction_Homo sapiens_hsa047400.71000449
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68922555
90Retinol metabolism_Homo sapiens_hsa008300.68677585
91Tight junction_Homo sapiens_hsa045300.68165552
92beta-Alanine metabolism_Homo sapiens_hsa004100.67836067
93One carbon pool by folate_Homo sapiens_hsa006700.67270375
94Nicotine addiction_Homo sapiens_hsa050330.67124584
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66869617
96Primary immunodeficiency_Homo sapiens_hsa053400.66546894
97Arachidonic acid metabolism_Homo sapiens_hsa005900.64354307
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63438390
99Chemical carcinogenesis_Homo sapiens_hsa052040.62951624
100Hippo signaling pathway_Homo sapiens_hsa043900.61277866
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.61036897
102FoxO signaling pathway_Homo sapiens_hsa040680.60482910
103Pancreatic cancer_Homo sapiens_hsa052120.59826882
104Fatty acid metabolism_Homo sapiens_hsa012120.59393882
105Dorso-ventral axis formation_Homo sapiens_hsa043200.59191984
106Hepatitis B_Homo sapiens_hsa051610.58967750
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58638555
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57855716
109Serotonergic synapse_Homo sapiens_hsa047260.57547362
110Metabolic pathways_Homo sapiens_hsa011000.56753079
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56693299
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56601005
113mRNA surveillance pathway_Homo sapiens_hsa030150.56294047
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56257744
115Proteoglycans in cancer_Homo sapiens_hsa052050.56114546
116Alzheimers disease_Homo sapiens_hsa050100.55889634
117Lysosome_Homo sapiens_hsa041420.51454170
118Adherens junction_Homo sapiens_hsa045200.51031282
119Herpes simplex infection_Homo sapiens_hsa051680.50232908
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50192949
121Glycerolipid metabolism_Homo sapiens_hsa005610.48591277
122Staphylococcus aureus infection_Homo sapiens_hsa051500.48257818
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47969013
124Legionellosis_Homo sapiens_hsa051340.47386602
125Allograft rejection_Homo sapiens_hsa053300.46370293
126Morphine addiction_Homo sapiens_hsa050320.46045184
127Insulin secretion_Homo sapiens_hsa049110.43815248
128Hematopoietic cell lineage_Homo sapiens_hsa046400.43786496
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43153964
130HTLV-I infection_Homo sapiens_hsa051660.42631979
131TNF signaling pathway_Homo sapiens_hsa046680.42507483
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41398332
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40842205
134Viral myocarditis_Homo sapiens_hsa054160.40553077
135Autoimmune thyroid disease_Homo sapiens_hsa053200.39403624
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.38650245
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38601528
138Melanoma_Homo sapiens_hsa052180.37931287
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35783880
140Colorectal cancer_Homo sapiens_hsa052100.35734766
141RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35702580
142Circadian entrainment_Homo sapiens_hsa047130.35176517
143Thyroid cancer_Homo sapiens_hsa052160.34690493
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.33528381
145Collecting duct acid secretion_Homo sapiens_hsa049660.32765891
146Pyruvate metabolism_Homo sapiens_hsa006200.32378460
147Graft-versus-host disease_Homo sapiens_hsa053320.31839587
148Vitamin digestion and absorption_Homo sapiens_hsa049770.28576966
149Renin-angiotensin system_Homo sapiens_hsa046140.27214149
150Salmonella infection_Homo sapiens_hsa051320.26646453
151Pathways in cancer_Homo sapiens_hsa052000.26174874
152Protein digestion and absorption_Homo sapiens_hsa049740.26172913
153Apoptosis_Homo sapiens_hsa042100.25688231
154Ovarian steroidogenesis_Homo sapiens_hsa049130.25314352
155Long-term depression_Homo sapiens_hsa047300.24053579

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