CMTM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor that regulates G1/S transition in the cell cycle, and epidermal growth factor receptor/protein kinase B signaling during tumor pathogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.14133495
2DNA deamination (GO:0045006)6.47179635
3viral transcription (GO:0019083)5.82789910
4translational termination (GO:0006415)5.60570323
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.01612352
6translational elongation (GO:0006414)5.00465564
7ribosomal small subunit biogenesis (GO:0042274)4.93944018
8cotranslational protein targeting to membrane (GO:0006613)4.89658922
9protein targeting to ER (GO:0045047)4.87022525
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.66943426
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.66943426
12protein localization to endoplasmic reticulum (GO:0070972)4.64440995
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.63383730
14telomere maintenance via semi-conservative replication (GO:0032201)4.59460656
15DNA strand elongation involved in DNA replication (GO:0006271)4.54788237
16maturation of SSU-rRNA (GO:0030490)4.54432255
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.40758422
18DNA strand elongation (GO:0022616)4.36944616
19viral life cycle (GO:0019058)4.34058018
20antigen processing and presentation via MHC class Ib (GO:0002475)4.32058021
21neutrophil activation involved in immune response (GO:0002283)4.26145268
22cellular protein complex disassembly (GO:0043624)4.24804444
23translational initiation (GO:0006413)4.21695854
24response to peptidoglycan (GO:0032494)3.97144844
25telomere maintenance via recombination (GO:0000722)3.87517066
26antigen processing and presentation of endogenous antigen (GO:0019883)3.85456047
27protein complex disassembly (GO:0043241)3.83002916
28DNA replication initiation (GO:0006270)3.78708382
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.76869705
30DNA unwinding involved in DNA replication (GO:0006268)3.68997530
31macromolecular complex disassembly (GO:0032984)3.60257341
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.59169564
33negative regulation of cell killing (GO:0031342)3.59169564
34positive regulation of B cell differentiation (GO:0045579)3.56887095
35platelet dense granule organization (GO:0060155)3.51864928
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.50909696
37mitotic recombination (GO:0006312)3.48038635
38detection of bacterium (GO:0016045)3.45971804
39detection of other organism (GO:0098543)3.42347328
40pseudouridine synthesis (GO:0001522)3.42318239
41nuclear-transcribed mRNA catabolic process (GO:0000956)3.42177710
42negative regulation of interleukin-12 production (GO:0032695)3.40887777
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.40581839
44ribosomal large subunit biogenesis (GO:0042273)3.39802178
45Arp2/3 complex-mediated actin nucleation (GO:0034314)3.38101752
46telomere maintenance via telomere lengthening (GO:0010833)3.36871658
47formation of translation preinitiation complex (GO:0001731)3.31996089
48ribonucleoprotein complex biogenesis (GO:0022613)3.28700476
49tolerance induction (GO:0002507)3.28144078
50mRNA catabolic process (GO:0006402)3.27498516
51lymphoid progenitor cell differentiation (GO:0002320)3.27406218
52negative regulation of phagocytosis (GO:0050765)3.25204248
53definitive hemopoiesis (GO:0060216)3.23554649
54protein targeting to membrane (GO:0006612)3.22318403
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.20414343
56positive regulation by organism of defense response of other organism involved in symbiotic interact3.20414343
57modulation by symbiont of host immune response (GO:0052553)3.20414343
58positive regulation by symbiont of host defense response (GO:0052509)3.20414343
59modulation by symbiont of host defense response (GO:0052031)3.20414343
60modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.20414343
61translation (GO:0006412)3.19929709
62response to interferon-beta (GO:0035456)3.19679331
63positive regulation of antigen processing and presentation (GO:0002579)3.16752550
64RNA catabolic process (GO:0006401)3.14487035
65regulation of B cell receptor signaling pathway (GO:0050855)3.10020596
66neutrophil activation (GO:0042119)3.07840887
67nucleotide-excision repair, DNA gap filling (GO:0006297)3.07725107
68positive thymic T cell selection (GO:0045059)3.06175591
69positive regulation of mast cell activation (GO:0033005)3.03877847
70nucleobase biosynthetic process (GO:0046112)3.02262093
71positive regulation of mast cell degranulation (GO:0043306)3.02228528
72positive regulation of mast cell activation involved in immune response (GO:0033008)3.02228528
73purine deoxyribonucleotide catabolic process (GO:0009155)3.00324411
74regulation of T cell tolerance induction (GO:0002664)2.99246217
75negative regulation of B cell apoptotic process (GO:0002903)2.96751078
76leukocyte aggregation (GO:0070486)2.94639368
77respiratory burst (GO:0045730)2.94541211
78regulation of antigen processing and presentation (GO:0002577)2.94430291
79myeloid cell activation involved in immune response (GO:0002275)2.92583679
80granulocyte activation (GO:0036230)2.91181820
81cellular extravasation (GO:0045123)2.89396203
82regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87524707
83rRNA processing (GO:0006364)2.86620639
84regulation of mast cell degranulation (GO:0043304)2.85861523
85negative regulation of erythrocyte differentiation (GO:0045647)2.85712750
86leukocyte degranulation (GO:0043299)2.85156475
87regulation of tolerance induction (GO:0002643)2.84506012
88interferon-gamma-mediated signaling pathway (GO:0060333)2.82625483
89mature B cell differentiation involved in immune response (GO:0002313)2.82540725
90pentose-phosphate shunt (GO:0006098)2.80942189
91negative thymic T cell selection (GO:0045060)2.80793693
92positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.80707447
93negative T cell selection (GO:0043383)2.80182742
94negative regulation of RNA splicing (GO:0033119)2.75376112
95rRNA metabolic process (GO:0016072)2.75073160
96IMP metabolic process (GO:0046040)2.74609507
97pinocytosis (GO:0006907)2.74298758
98regulation of myeloid leukocyte mediated immunity (GO:0002886)2.73573763
99purine-containing compound salvage (GO:0043101)2.73447652
100positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73278547
101regulation of gamma-delta T cell activation (GO:0046643)2.72342340
102exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71898277
103immunoglobulin mediated immune response (GO:0016064)2.71424172
104purine nucleobase biosynthetic process (GO:0009113)2.69138386
105regulation of B cell apoptotic process (GO:0002902)2.68666922
106detection of external biotic stimulus (GO:0098581)2.68558336
107positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67954719
108endosome to melanosome transport (GO:0035646)2.67930863
109endosome to pigment granule transport (GO:0043485)2.67930863
110regulation of B cell differentiation (GO:0045577)2.66825927
111defense response to protozoan (GO:0042832)2.66360896
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.65829384
113ribosome biogenesis (GO:0042254)2.63967631
114autophagic vacuole fusion (GO:0000046)2.63578896
115mast cell activation (GO:0045576)2.63337910
116deoxyribonucleotide catabolic process (GO:0009264)2.62453468
117cellular response to type I interferon (GO:0071357)2.62374125
118type I interferon signaling pathway (GO:0060337)2.62374125
119DNA replication checkpoint (GO:0000076)2.61304516
120regulation of mast cell activation (GO:0033003)2.60850053
121response to protozoan (GO:0001562)2.60368825
122CENP-A containing nucleosome assembly (GO:0034080)2.59562130
123translesion synthesis (GO:0019985)2.59549653
124response to type I interferon (GO:0034340)2.59334505
125macrophage activation involved in immune response (GO:0002281)2.59228091
126cellular component biogenesis (GO:0044085)2.58774825
127T cell homeostasis (GO:0043029)2.58375769
128regulation of superoxide anion generation (GO:0032928)2.57247231
129regulation of mast cell activation involved in immune response (GO:0033006)2.57010803
130positive regulation of gamma-delta T cell activation (GO:0046645)2.56507652
131necroptotic process (GO:0070266)2.55963008
132positive regulation of interleukin-8 secretion (GO:2000484)2.55575211
133nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54639428
134antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.54136173
135deoxyribose phosphate catabolic process (GO:0046386)2.53607778
136IMP biosynthetic process (GO:0006188)2.53287822
137regulation of T cell mediated cytotoxicity (GO:0001914)2.53247846
138respiratory chain complex IV assembly (GO:0008535)2.53068267
139regulation of leukocyte degranulation (GO:0043300)2.52468018
140regulation of gamma-delta T cell differentiation (GO:0045586)2.52217506
141response to interferon-alpha (GO:0035455)2.49955548
142secretory granule organization (GO:0033363)2.49230791
143B cell mediated immunity (GO:0019724)2.48904570
144regulation of alpha-beta T cell proliferation (GO:0046640)2.48503740
145regulation of regulatory T cell differentiation (GO:0045589)2.48264911
146telomere maintenance (GO:0000723)2.48013211
147lipopolysaccharide-mediated signaling pathway (GO:0031663)2.47930456
148response to muramyl dipeptide (GO:0032495)2.47920124
149telomere organization (GO:0032200)2.47668451
150negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.47372970
151viral mRNA export from host cell nucleus (GO:0046784)2.46875308
152negative regulation of T cell mediated immunity (GO:0002710)2.46618854
153positive regulation of tolerance induction (GO:0002645)2.46165158
154G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.45801525
155response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.45571948
156response to host immune response (GO:0052572)2.45571948
157negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.45016079
158negative regulation of cytokine production involved in immune response (GO:0002719)2.44827424
159negative regulation of nitric oxide biosynthetic process (GO:0045019)2.43427789
160chromatin remodeling at centromere (GO:0031055)2.43345063
161purine nucleotide salvage (GO:0032261)2.42611003
162mast cell activation involved in immune response (GO:0002279)2.42597189
163mast cell degranulation (GO:0043303)2.42597189
164detection of biotic stimulus (GO:0009595)2.42437752
165negative regulation of lymphocyte apoptotic process (GO:0070229)2.41917657
166positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.41876875
167T cell migration (GO:0072678)2.41837475
168proteasome assembly (GO:0043248)2.41022555
169negative regulation of myeloid cell apoptotic process (GO:0033033)2.40996188
170ncRNA 3-end processing (GO:0043628)2.40971039
171NADPH regeneration (GO:0006740)2.40817433
172iron-sulfur cluster assembly (GO:0016226)2.40741039
173metallo-sulfur cluster assembly (GO:0031163)2.40741039
174regulation of protein heterodimerization activity (GO:0043497)2.40626820
175actin nucleation (GO:0045010)2.39743733
176establishment of integrated proviral latency (GO:0075713)2.39040391
177regulation of erythrocyte differentiation (GO:0045646)2.38345794
178DNA replication-independent nucleosome organization (GO:0034724)2.37867888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.27884034
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91401544
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.53922528
4ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80768799
5SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.78285061
6SCL_19346495_ChIP-Seq_HPC-7_Human2.68325430
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56005691
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52242080
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50358079
10* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.50127577
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.46004467
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.45186916
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44322409
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42989461
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41997573
16VDR_21846776_ChIP-Seq_THP-1_Human2.36919998
17MYC_22102868_ChIP-Seq_BL_Human2.35815276
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.34195628
19* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.32603497
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31810589
21* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26698200
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24464813
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.19903654
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17686111
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17112302
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.12544601
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11914618
28VDR_23849224_ChIP-Seq_CD4+_Human2.11521171
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07503167
30* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04197298
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03724598
32ERG_20887958_ChIP-Seq_HPC-7_Mouse1.99084000
33SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.99070345
34XRN2_22483619_ChIP-Seq_HELA_Human1.96624299
35FOXP3_21729870_ChIP-Seq_TREG_Human1.92201815
36SPI1_23547873_ChIP-Seq_NB4_Human1.91717472
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89086993
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.87365967
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.87013383
40* IRF8_27001747_Chip-Seq_BMDM_Mouse1.83408699
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82159106
42CIITA_25753668_ChIP-Seq_RAJI_Human1.82070314
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79742924
44GATA1_22025678_ChIP-Seq_K562_Human1.73495198
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.70828174
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68010885
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65816117
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65353552
49GABP_19822575_ChIP-Seq_HepG2_Human1.63225750
50DCP1A_22483619_ChIP-Seq_HELA_Human1.62541574
51VDR_24763502_ChIP-Seq_THP-1_Human1.60039941
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57722453
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56747394
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.56271008
55GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.53394838
56SPI1_23127762_ChIP-Seq_K562_Human1.48173841
57* RUNX1_22412390_ChIP-Seq_EML_Mouse1.48042918
58TTF2_22483619_ChIP-Seq_HELA_Human1.46531746
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46469204
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.44949014
61* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44318979
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43350588
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42663425
64* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41131512
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.41002959
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.40333662
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40315082
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40131861
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40117000
70RUNX_20019798_ChIP-Seq_JUKART_Human1.39569260
71* BCL6_27268052_Chip-Seq_Bcells_Human1.38488013
72* MYB_26560356_Chip-Seq_TH2_Human1.38066417
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.37179872
74MAF_26560356_Chip-Seq_TH1_Human1.37091157
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37009614
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36043350
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35425450
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34144003
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.34067636
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33136030
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31995578
82YY1_21170310_ChIP-Seq_MESCs_Mouse1.31383447
83* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30200996
84UTX_26944678_Chip-Seq_JUKART_Human1.29464114
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28841705
86MYB_26560356_Chip-Seq_TH1_Human1.28798192
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27422574
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26576491
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25215525
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23577876
91ELK1_19687146_ChIP-ChIP_HELA_Human1.23071427
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22326552
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22161017
94* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21593782
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21136719
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20749920
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20626924
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20265807
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20043302
100* BCOR_27268052_Chip-Seq_Bcells_Human1.17213171
101STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.17152891
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16036457
103GATA3_27048872_Chip-Seq_THYMUS_Human1.15488788
104MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14909701
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14701958
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12062241
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11595737
108GATA3_26560356_Chip-Seq_TH2_Human1.10826780
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10702236
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09896058
111* TCF7_22412390_ChIP-Seq_EML_Mouse1.09652435
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08806790
113AR_21909140_ChIP-Seq_LNCAP_Human1.06687238
114GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04380990
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03809187
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03529717
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03460982
118TFEB_21752829_ChIP-Seq_HELA_Human1.03409351
119KDM5A_27292631_Chip-Seq_BREAST_Human1.03260609
120LXR_22292898_ChIP-Seq_THP-1_Human1.02861002
121* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01854944
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01804849
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01699310
124EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01459434
125TET1_21451524_ChIP-Seq_MESCs_Mouse1.01145722
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00191644
127MAF_26560356_Chip-Seq_TH2_Human0.99577061
128CTCF_26484167_Chip-Seq_Bcells_Mouse0.98958022
129NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97842211
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97037186
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96510844
132* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95959932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.50098274
2MP0003693_abnormal_embryo_hatching3.36777113
3MP0001835_abnormal_antigen_presentation3.32692444
4MP0005397_hematopoietic_system_phenotyp2.79772240
5MP0001545_abnormal_hematopoietic_system2.79772240
6MP0004808_abnormal_hematopoietic_stem2.66548289
7MP0000685_abnormal_immune_system2.65575304
8MP0005174_abnormal_tail_pigmentation2.58131354
9MP0010094_abnormal_chromosome_stability2.55995840
10MP0009785_altered_susceptibility_to2.54922561
11MP0003806_abnormal_nucleotide_metabolis2.52690059
12MP0005075_abnormal_melanosome_morpholog2.48706999
13MP0000490_abnormal_crypts_of2.42892337
14MP0005671_abnormal_response_to2.38560643
15MP0004957_abnormal_blastocyst_morpholog2.32641391
16MP0002398_abnormal_bone_marrow2.31798753
17MP0000465_gastrointestinal_hemorrhage2.31596529
18MP0005464_abnormal_platelet_physiology2.30722598
19MP0003763_abnormal_thymus_physiology2.27822154
20MP0003111_abnormal_nucleus_morphology2.22151861
21MP0005025_abnormal_response_to2.22101063
22MP0003077_abnormal_cell_cycle2.20201946
23MP0008007_abnormal_cellular_replicative2.19230195
24MP0008057_abnormal_DNA_replication2.18172622
25MP0001800_abnormal_humoral_immune2.09672865
26MP0002420_abnormal_adaptive_immunity2.06267900
27MP0009333_abnormal_splenocyte_physiolog2.04216541
28MP0001819_abnormal_immune_cell2.02235215
29MP0000689_abnormal_spleen_morphology2.01595626
30MP0003436_decreased_susceptibility_to2.01153580
31MP0002166_altered_tumor_susceptibility1.99398995
32MP0002452_abnormal_antigen_presenting1.97843652
33MP0008058_abnormal_DNA_repair1.95896086
34MP0002722_abnormal_immune_system1.95683350
35MP0000716_abnormal_immune_system1.95507785
36MP0002723_abnormal_immune_serum1.94314211
37MP0002419_abnormal_innate_immunity1.91490497
38MP0009379_abnormal_foot_pigmentation1.91134010
39MP0005000_abnormal_immune_tolerance1.90190753
40MP0001853_heart_inflammation1.88862224
41MP0003724_increased_susceptibility_to1.87229458
42MP0002429_abnormal_blood_cell1.86585213
43MP0002148_abnormal_hypersensitivity_rea1.83450253
44MP0001873_stomach_inflammation1.79773291
45MP0002095_abnormal_skin_pigmentation1.71229936
46MP0009764_decreased_sensitivity_to1.61046793
47MP0003075_altered_response_to1.58665606
48MP0010155_abnormal_intestine_physiology1.56961443
49MP0000703_abnormal_thymus_morphology1.56857363
50MP0002019_abnormal_tumor_incidence1.55404661
51MP0002006_tumorigenesis1.54561773
52MP0003866_abnormal_defecation1.52660938
53MP0002277_abnormal_respiratory_mucosa1.52620264
54MP0002405_respiratory_system_inflammati1.49204499
55MP0006054_spinal_hemorrhage1.45165467
56MP0005387_immune_system_phenotype1.40188191
57MP0001790_abnormal_immune_system1.40188191
58MP0009278_abnormal_bone_marrow1.36377519
59MP0003172_abnormal_lysosome_physiology1.34225902
60MP0001845_abnormal_inflammatory_respons1.29534897
61MP0001986_abnormal_taste_sensitivity1.29267504
62MP0003303_peritoneal_inflammation1.29154205
63MP0000015_abnormal_ear_pigmentation1.28363968
64MP0005451_abnormal_body_composition1.27177892
65MP0004147_increased_porphyrin_level1.26468179
66MP0003656_abnormal_erythrocyte_physiolo1.21874807
67MP0008260_abnormal_autophagy1.21748103
68MP0000313_abnormal_cell_death1.21248766
69MP0005166_decreased_susceptibility_to1.16823431
70MP0000858_altered_metastatic_potential1.15389199
71MP0008469_abnormal_protein_level1.14860183
72MP0003186_abnormal_redox_activity1.14403651
73MP0006036_abnormal_mitochondrial_physio1.14242415
74MP0003786_premature_aging1.12563766
75MP0002138_abnormal_hepatobiliary_system1.11396097
76MP0002877_abnormal_melanocyte_morpholog1.10450862
77MP0010352_gastrointestinal_tract_polyps1.09080033
78MP0010307_abnormal_tumor_latency1.07607132
79MP0000350_abnormal_cell_proliferation0.99635801
80MP0001851_eye_inflammation0.98886730
81MP0002998_abnormal_bone_remodeling0.97071584
82MP0005390_skeleton_phenotype0.93482907
83MP0000343_altered_response_to0.92213195
84MP0008932_abnormal_embryonic_tissue0.91981629
85MP0001533_abnormal_skeleton_physiology0.89771099
86MP0005165_increased_susceptibility_to0.89561721
87MP0002132_abnormal_respiratory_system0.88931781
88MP0003448_altered_tumor_morphology0.86255242
89MP0000358_abnormal_cell_content/0.86048185
90MP0005058_abnormal_lysosome_morphology0.85688497
91MP0001542_abnormal_bone_strength0.83064242
92MP0004947_skin_inflammation0.81575487
93MP0001663_abnormal_digestive_system0.81415562
94MP0005164_abnormal_response_to0.80015527
95MP0009840_abnormal_foam_cell0.78241974
96MP0000477_abnormal_intestine_morphology0.76327253
97MP0009765_abnormal_xenobiotic_induced0.75201650
98MP0004510_myositis0.74897091
99MP0005310_abnormal_salivary_gland0.74618485
100MP0004883_abnormal_blood_vessel0.74615142
101MP0003567_abnormal_fetal_cardiomyocyte0.73871417
102MP0003221_abnormal_cardiomyocyte_apopto0.73663874
103MP0003191_abnormal_cellular_cholesterol0.73296034
104MP0003300_gastrointestinal_ulcer0.72454450
105MP0002080_prenatal_lethality0.71223759
106MP0002933_joint_inflammation0.71222066
107MP0001730_embryonic_growth_arrest0.70850397
108MP0006292_abnormal_olfactory_placode0.70696457
109MP0003943_abnormal_hepatobiliary_system0.69926780
110MP0000249_abnormal_blood_vessel0.69708488
111MP0002075_abnormal_coat/hair_pigmentati0.68714143
112MP0005319_abnormal_enzyme/_coenzyme0.68294833
113MP0003315_abnormal_perineum_morphology0.67616073
114MP0008873_increased_physiological_sensi0.67465459
115MP0000371_diluted_coat_color0.67083338
116MP0003183_abnormal_peptide_metabolism0.66673165
117MP0003795_abnormal_bone_structure0.66328996
118MP0001764_abnormal_homeostasis0.65997220
119MP0002653_abnormal_ependyma_morphology0.62981501
120MP0009763_increased_sensitivity_to0.62614612
121MP0006035_abnormal_mitochondrial_morpho0.61846734
122MP0000598_abnormal_liver_morphology0.60710158
123MP0004381_abnormal_hair_follicle0.59676286
124MP0000604_amyloidosis0.58481686
125MP0003828_pulmonary_edema0.58351361
126MP0005409_darkened_coat_color0.57752753
127MP0002163_abnormal_gland_morphology0.56451741
128MP0001348_abnormal_lacrimal_gland0.56302148
129MP0006082_CNS_inflammation0.55251803
130MP0000681_abnormal_thyroid_gland0.54216810
131MP0004185_abnormal_adipocyte_glucose0.54169039
132MP0005084_abnormal_gallbladder_morpholo0.52496236

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.78707480
2Abnormal number of erythroid precursors (HP:0012131)5.73351839
3Thrombocytosis (HP:0001894)5.39257640
4Aplastic anemia (HP:0001915)5.37531579
5Reticulocytopenia (HP:0001896)4.89579530
6Elevated erythrocyte sedimentation rate (HP:0003565)4.41442183
7Chronic otitis media (HP:0000389)4.40657107
8IgM deficiency (HP:0002850)4.32110006
9Petechiae (HP:0000967)4.04973347
10Stomatitis (HP:0010280)4.03660932
11Reduced antithrombin III activity (HP:0001976)3.88862230
12Abnormality of liposaccharide metabolism (HP:0010968)3.75579518
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.75579518
14Abnormality of glycolipid metabolism (HP:0010969)3.75579518
15Type I transferrin isoform profile (HP:0003642)3.68701928
16Vacuolated lymphocytes (HP:0001922)3.62014794
17Pallor (HP:0000980)3.56973254
18Myositis (HP:0100614)3.36820353
19Pustule (HP:0200039)3.30559793
20Macrocytic anemia (HP:0001972)3.29003088
21Increased IgM level (HP:0003496)3.20379211
22Prolonged bleeding time (HP:0003010)3.18981958
23Recurrent abscess formation (HP:0002722)3.17832660
24Recurrent bronchitis (HP:0002837)3.08856333
25Abnormal glycosylation (HP:0012345)3.08577120
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.08577120
27Abnormal protein N-linked glycosylation (HP:0012347)3.08577120
28Abnormal protein glycosylation (HP:0012346)3.08577120
29Abnormality of T cell physiology (HP:0011840)3.06221994
30Orchitis (HP:0100796)3.04144880
31Chronic mucocutaneous candidiasis (HP:0002728)2.97993353
32Recurrent cutaneous fungal infections (HP:0011370)2.97993353
33Increased cerebral lipofuscin (HP:0011813)2.88126011
34T lymphocytopenia (HP:0005403)2.85836243
35Dysostosis multiplex (HP:0000943)2.84631369
36Abnormality of T cell number (HP:0011839)2.84425490
37Recurrent bacterial skin infections (HP:0005406)2.82482636
38Urticaria (HP:0001025)2.77324083
39Poikiloderma (HP:0001029)2.75422548
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.75073876
41Autoimmune hemolytic anemia (HP:0001890)2.73734797
42Panhypogammaglobulinemia (HP:0003139)2.73678739
43Severe combined immunodeficiency (HP:0004430)2.73466220
44Recurrent viral infections (HP:0004429)2.72776940
45Abnormal platelet function (HP:0011869)2.71621261
46Impaired platelet aggregation (HP:0003540)2.71621261
47Hepatosplenomegaly (HP:0001433)2.68157096
48Nasal polyposis (HP:0100582)2.67266090
49Pulmonary infiltrates (HP:0002113)2.67028575
50Oral leukoplakia (HP:0002745)2.62786177
51Microretrognathia (HP:0000308)2.61908397
52Acute lymphatic leukemia (HP:0006721)2.61844667
53Cellulitis (HP:0100658)2.61561255
54Muscle fiber atrophy (HP:0100295)2.59446489
55Abnormality of the nasal mucosa (HP:0000433)2.57502618
56Autoimmune thrombocytopenia (HP:0001973)2.57216825
57Epistaxis (HP:0000421)2.57173091
58Pancytopenia (HP:0001876)2.57054812
59Optic neuritis (HP:0100653)2.55914200
60Retrobulbar optic neuritis (HP:0100654)2.55914200
61Eosinophilia (HP:0001880)2.55693720
62Recurrent gram-negative bacterial infections (HP:0005420)2.55430467
63Meningitis (HP:0001287)2.53625803
64Vasculitis (HP:0002633)2.48929465
65Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47342172
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47342172
67Amyloidosis (HP:0011034)2.47224917
68Mitochondrial inheritance (HP:0001427)2.46482011
69Type 2 muscle fiber atrophy (HP:0003554)2.45856455
70B lymphocytopenia (HP:0010976)2.43055545
71Abnormality of B cell number (HP:0010975)2.43055545
72Combined immunodeficiency (HP:0005387)2.41752377
73Loss of speech (HP:0002371)2.41185539
74Increased IgE level (HP:0003212)2.40856962
75Leukocytosis (HP:0001974)2.39860298
76Abnormal delayed hypersensitivity skin test (HP:0002963)2.38832789
77Myelodysplasia (HP:0002863)2.38271382
78Encephalitis (HP:0002383)2.37723834
79Abnormality of the heme biosynthetic pathway (HP:0010472)2.37483740
80Colon cancer (HP:0003003)2.37454263
81Recurrent fungal infections (HP:0002841)2.35106190
82Lymphoma (HP:0002665)2.32774609
83Abnormality of the prostate (HP:0008775)2.31886680
8411 pairs of ribs (HP:0000878)2.29333457
85Hypertensive crisis (HP:0100735)2.29222225
86Abnormality of T cells (HP:0002843)2.28656551
87Severe visual impairment (HP:0001141)2.27996501
88Entropion (HP:0000621)2.27104894
89Gastrointestinal inflammation (HP:0004386)2.26596657
90Polygenic inheritance (HP:0010982)2.25994931
91Hepatocellular necrosis (HP:0001404)2.25033355
92Increased serum ferritin (HP:0003281)2.24156623
93Albinism (HP:0001022)2.21658341
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20147628
95IgG deficiency (HP:0004315)2.18398000
96Abnormal mitochondria in muscle tissue (HP:0008316)2.16944299
97Inflammation of the large intestine (HP:0002037)2.16322716
98Interstitial pulmonary disease (HP:0006530)2.16126905
99Progressive neurologic deterioration (HP:0002344)2.16001523
100Birth length less than 3rd percentile (HP:0003561)2.14918746
101Acute myeloid leukemia (HP:0004808)2.14835990
102Abnormality of the columella (HP:0009929)2.13278278
103Hepatic necrosis (HP:0002605)2.12497611
104Abnormality of eosinophils (HP:0001879)2.11423303
105Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10432110
106Anorexia (HP:0002039)2.09639104
107Abnormality of macrophages (HP:0004311)2.08682642
108Gastrointestinal infarctions (HP:0005244)2.07910204
109Obstructive lung disease (HP:0006536)2.06723570
110Chronic obstructive pulmonary disease (HP:0006510)2.06723570
111Acute necrotizing encephalopathy (HP:0006965)2.06329908
112Agammaglobulinemia (HP:0004432)2.06297241
113Recurrent skin infections (HP:0001581)2.06161190
114Neutropenia (HP:0001875)2.05569092
115Lymphopenia (HP:0001888)2.05385113
116Hemoptysis (HP:0002105)2.05331002
117Amaurosis fugax (HP:0100576)2.04905846
118Abnormality of cells of the lymphoid lineage (HP:0012140)2.04390152
119Pulmonary fibrosis (HP:0002206)2.03975998
120Verrucae (HP:0200043)2.02025556
121Papilloma (HP:0012740)2.02025556
122Microcytic anemia (HP:0001935)2.01590370
123Increased muscle lipid content (HP:0009058)2.00737711
124Increased CSF lactate (HP:0002490)1.99242833
125Hypoplasia of the thymus (HP:0000778)1.98149918
126Episodic fever (HP:0001954)1.98019422
127Skin rash (HP:0000988)1.97495187
128Abnormality of iron homeostasis (HP:0011031)1.96163997
129Mediastinal lymphadenopathy (HP:0100721)1.96058920
130Chronic sinusitis (HP:0011109)1.95649095
131Exertional dyspnea (HP:0002875)1.94673133
132Broad face (HP:0000283)1.94158294
133Agnosia (HP:0010524)1.94007157
134Abnormality of polysaccharide metabolism (HP:0011012)1.93588700
135Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93588700
136Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93588700
137Fatigue (HP:0012378)1.93456141
138Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93106937
139Poor head control (HP:0002421)1.92695622
140Bone marrow hypocellularity (HP:0005528)1.92590783
141Sepsis (HP:0100806)1.92434639
142Eczematoid dermatitis (HP:0000976)1.92279263
143Erythema (HP:0010783)1.91471373
144Abnormality of DNA repair (HP:0003254)1.91350536
145Keratoconjunctivitis sicca (HP:0001097)1.90972687
146Skin ulcer (HP:0200042)1.90209727
147Granulocytopenia (HP:0001913)1.88916041
148Thoracic kyphosis (HP:0002942)1.88897749
149Progressive muscle weakness (HP:0003323)1.88381914
150Chest pain (HP:0100749)1.87519551
151Abnormality of the thoracic spine (HP:0100711)1.82521140
152Increased intramyocellular lipid droplets (HP:0012240)1.80992328
1533-Methylglutaconic aciduria (HP:0003535)1.80157528
154Hypergammaglobulinemia (HP:0010702)1.75208758
155Hypoproteinemia (HP:0003075)1.74973070
156Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74905249
157Purpura (HP:0000979)1.74859970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.81713710
2KIT3.05419079
3WEE13.01043255
4NME22.89840593
5VRK22.76397548
6FLT32.76366168
7EEF2K2.74880698
8PIM22.56247691
9MAP4K12.52758689
10BUB12.31564085
11SCYL22.22324818
12TEC2.19087197
13BTK2.10928690
14CDK192.10655373
15TNIK2.03746309
16EIF2AK31.98552937
17ACVR1B1.97359138
18RPS6KB21.89529393
19CSK1.86350374
20CSF1R1.82443794
21TESK11.74767218
22VRK11.71614561
23MAP3K31.69579335
24MAP2K31.62691884
25CDC71.60493247
26TGFBR11.54493026
27DYRK31.52255175
28NEK21.50463763
29MAPKAPK31.45218377
30IRAK41.43001613
31KDR1.42641552
32BRSK21.42113994
33MAP3K121.41186623
34BLK1.39483522
35MAP3K141.36070694
36IRAK31.31814528
37MAP3K131.30244086
38EIF2AK11.29583570
39FES1.28944479
40SYK1.28863915
41TAOK21.28731453
42TESK21.27767434
43LRRK21.27594892
44ARAF1.27220949
45PKN21.26741469
46TBK11.25501434
47ZAP701.23821767
48MATK1.19465088
49EPHA21.19387058
50ABL21.16659775
51CDK71.15034850
52BMPR21.10399883
53JAK31.05405419
54GRK71.03224310
55BCKDK1.02664856
56CAMKK21.02418428
57CCNB11.00571999
58RPS6KA40.99288759
59PIM10.97823832
60MST40.97322648
61MUSK0.96794709
62CDK40.95441738
63TYK20.95099727
64ATR0.95061407
65EPHB10.94184761
66MAP3K110.94031718
67PAK40.93376376
68NLK0.92769329
69ERN10.92190511
70RAF10.89658249
71MAPKAPK50.89006503
72PASK0.88719013
73SRPK10.88652158
74MKNK10.87285774
75GRK60.86350808
76MAP3K100.84558788
77LYN0.84494321
78LMTK20.84094904
79MOS0.83699064
80TGFBR20.80851793
81IKBKE0.80646847
82TAOK10.80199274
83TSSK60.79378324
84TLK10.78486674
85PRPF4B0.76468586
86DAPK10.74506980
87LIMK10.74241924
88CDK80.73354298
89FGR0.70710377
90HIPK20.69569106
91LCK0.69142710
92TAOK30.68743709
93AURKB0.67938744
94ILK0.67051728
95BRSK10.66561203
96IKBKB0.65972984
97STK100.65457586
98MARK30.64432487
99PRKD20.64122173
100MAP3K10.64100685
101MAPK40.64058204
102PRKCI0.63108423
103MAP3K60.61370638
104TXK0.59696559
105MAP3K80.58259895
106TRIB30.58007375
107PLK10.53978672
108CLK10.53116647
109PTK2B0.52852583
110PRKCQ0.52388395
111MAPK110.51263020
112MAPKAPK20.50650017
113HCK0.49624157
114MKNK20.48464828
115ADRBK20.47885692
116PRKG20.47851011
117ITK0.47630205
118CAMK10.47370772
119STK40.46852489
120EIF2AK20.45989732
121RPS6KA60.44514554
122TNK20.43649726
123MYLK0.43202255
124JAK20.41974204
125IRAK10.41231447
126RIPK40.38761734
127RPS6KL10.38713712
128RPS6KC10.38713712
129JAK10.38640192
130PAK10.38607587
131BMPR1B0.37087271
132SMG10.36096356
133CSNK2A20.35307656
134PLK40.35240896
135CSNK2A10.33485185
136ADRBK10.33441595
137BRAF0.28538332
138PDK10.28458699
139CHUK0.27692590
140MST1R0.26867312
141PTK60.26629852

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.15847381
2Ribosome_Homo sapiens_hsa030104.93006580
3Mismatch repair_Homo sapiens_hsa034303.63204736
4Autoimmune thyroid disease_Homo sapiens_hsa053203.06547120
5Base excision repair_Homo sapiens_hsa034102.98325829
6Graft-versus-host disease_Homo sapiens_hsa053322.90579833
7Homologous recombination_Homo sapiens_hsa034402.68540602
8Proteasome_Homo sapiens_hsa030502.59575166
9Spliceosome_Homo sapiens_hsa030402.43998938
10Pyrimidine metabolism_Homo sapiens_hsa002402.35658259
11Staphylococcus aureus infection_Homo sapiens_hsa051502.34925620
12Nucleotide excision repair_Homo sapiens_hsa034202.30698149
13Type I diabetes mellitus_Homo sapiens_hsa049402.28297122
14RNA polymerase_Homo sapiens_hsa030202.22621550
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07210077
16Primary immunodeficiency_Homo sapiens_hsa053402.02915920
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97986513
18Non-homologous end-joining_Homo sapiens_hsa034501.77878501
19Rheumatoid arthritis_Homo sapiens_hsa053231.74278018
20Oxidative phosphorylation_Homo sapiens_hsa001901.73399023
21Viral myocarditis_Homo sapiens_hsa054161.71254352
22Cell cycle_Homo sapiens_hsa041101.70362678
23RNA transport_Homo sapiens_hsa030131.62880396
24Pentose phosphate pathway_Homo sapiens_hsa000301.59465157
25N-Glycan biosynthesis_Homo sapiens_hsa005101.57505736
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51199326
27Antigen processing and presentation_Homo sapiens_hsa046121.50839919
28Lysosome_Homo sapiens_hsa041421.44658734
29Sulfur relay system_Homo sapiens_hsa041221.44288100
30One carbon pool by folate_Homo sapiens_hsa006701.42508648
31Fanconi anemia pathway_Homo sapiens_hsa034601.41108251
32RNA degradation_Homo sapiens_hsa030181.39064276
33Protein export_Homo sapiens_hsa030601.38489277
34Folate biosynthesis_Homo sapiens_hsa007901.32869395
35Herpes simplex infection_Homo sapiens_hsa051681.31498452
36Parkinsons disease_Homo sapiens_hsa050121.27971770
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23550201
38Other glycan degradation_Homo sapiens_hsa005111.22281054
39Purine metabolism_Homo sapiens_hsa002301.19022044
40Leishmaniasis_Homo sapiens_hsa051401.17514716
41B cell receptor signaling pathway_Homo sapiens_hsa046621.15134279
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15087721
43Phagosome_Homo sapiens_hsa041451.14837235
44Hematopoietic cell lineage_Homo sapiens_hsa046401.14136686
45p53 signaling pathway_Homo sapiens_hsa041151.09652151
46T cell receptor signaling pathway_Homo sapiens_hsa046601.08354303
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07135409
48Measles_Homo sapiens_hsa051621.06146566
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96013732
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95861233
51Legionellosis_Homo sapiens_hsa051340.95505793
52Systemic lupus erythematosus_Homo sapiens_hsa053220.95346631
53Acute myeloid leukemia_Homo sapiens_hsa052210.94486284
54Shigellosis_Homo sapiens_hsa051310.91877652
55Basal transcription factors_Homo sapiens_hsa030220.91000704
56Epstein-Barr virus infection_Homo sapiens_hsa051690.90715744
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88558675
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.87993807
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.86564086
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84542186
61Huntingtons disease_Homo sapiens_hsa050160.84302972
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.83627207
63African trypanosomiasis_Homo sapiens_hsa051430.82966962
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81241031
65Collecting duct acid secretion_Homo sapiens_hsa049660.80893712
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78506307
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78402135
68Thyroid cancer_Homo sapiens_hsa052160.78320024
69Alzheimers disease_Homo sapiens_hsa050100.77648818
70Asthma_Homo sapiens_hsa053100.75953096
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.75787881
72Caffeine metabolism_Homo sapiens_hsa002320.75152127
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73983176
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.73777797
75Galactose metabolism_Homo sapiens_hsa000520.72000537
76TNF signaling pathway_Homo sapiens_hsa046680.70212781
77Renin-angiotensin system_Homo sapiens_hsa046140.69496261
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68824699
79Chemokine signaling pathway_Homo sapiens_hsa040620.67415922
80Hepatitis B_Homo sapiens_hsa051610.66867364
81Apoptosis_Homo sapiens_hsa042100.65832863
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65015125
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64318596
84Viral carcinogenesis_Homo sapiens_hsa052030.64108631
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63473389
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.61958914
87Pertussis_Homo sapiens_hsa051330.61601531
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61542454
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61033526
90Influenza A_Homo sapiens_hsa051640.60083933
91Platelet activation_Homo sapiens_hsa046110.59995151
92Osteoclast differentiation_Homo sapiens_hsa043800.59334781
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.59162764
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58649388
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56403110
96Selenocompound metabolism_Homo sapiens_hsa004500.56092019
97Biosynthesis of amino acids_Homo sapiens_hsa012300.51476380
98Hepatitis C_Homo sapiens_hsa051600.51348531
99Regulation of autophagy_Homo sapiens_hsa041400.50340007
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48949273
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48430843
102HTLV-I infection_Homo sapiens_hsa051660.48345243
103Allograft rejection_Homo sapiens_hsa053300.44816269
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44603769
105Toxoplasmosis_Homo sapiens_hsa051450.43619434
106Glutathione metabolism_Homo sapiens_hsa004800.43470684
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43446624
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41409352
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41374187
110Chronic myeloid leukemia_Homo sapiens_hsa052200.40897639
111mRNA surveillance pathway_Homo sapiens_hsa030150.40710295
112Small cell lung cancer_Homo sapiens_hsa052220.39317705
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38095296
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38012336
115Endocytosis_Homo sapiens_hsa041440.37515168
116Salmonella infection_Homo sapiens_hsa051320.36443809
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36058842
118Fructose and mannose metabolism_Homo sapiens_hsa000510.35965589
119Malaria_Homo sapiens_hsa051440.35802757
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35751981
121Pancreatic cancer_Homo sapiens_hsa052120.35549792
122Tuberculosis_Homo sapiens_hsa051520.35237008
123Arachidonic acid metabolism_Homo sapiens_hsa005900.35228098
124Fatty acid elongation_Homo sapiens_hsa000620.34780818
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34120985
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.33673640
127Carbon metabolism_Homo sapiens_hsa012000.29108385
128Non-small cell lung cancer_Homo sapiens_hsa052230.27498374
129Vibrio cholerae infection_Homo sapiens_hsa051100.23006904

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