CMIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a c-Maf inducing protein that plays a role in T-cell signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tachykinin receptor signaling pathway (GO:0007217)5.40053011
2neuron cell-cell adhesion (GO:0007158)5.22036973
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.19463768
4synaptic vesicle maturation (GO:0016188)5.13745821
5vocalization behavior (GO:0071625)5.08808868
6locomotory exploration behavior (GO:0035641)5.04686827
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95746440
8synaptic vesicle exocytosis (GO:0016079)4.92663635
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.75840425
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.70610325
11glutamate secretion (GO:0014047)4.58291990
12regulation of synaptic vesicle exocytosis (GO:2000300)4.57488393
13positive regulation of digestive system process (GO:0060456)4.46119006
14protein localization to synapse (GO:0035418)4.45017539
15layer formation in cerebral cortex (GO:0021819)4.40506169
16regulation of glutamate receptor signaling pathway (GO:1900449)4.35379335
17exploration behavior (GO:0035640)4.21630733
18dendritic spine morphogenesis (GO:0060997)4.17818993
19neuron recognition (GO:0008038)4.14434087
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.13409115
21regulation of synaptic vesicle transport (GO:1902803)3.96146065
22neurotransmitter secretion (GO:0007269)3.77145707
23regulation of long-term neuronal synaptic plasticity (GO:0048169)3.76941257
24axonal fasciculation (GO:0007413)3.76739456
25proline transport (GO:0015824)3.75676037
26regulation of neuronal synaptic plasticity (GO:0048168)3.74898411
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.70351071
28glutamate receptor signaling pathway (GO:0007215)3.68254262
29neuronal action potential propagation (GO:0019227)3.63547493
30synaptic vesicle docking involved in exocytosis (GO:0016081)3.60417593
31cochlea development (GO:0090102)3.49835060
32regulation of synapse structural plasticity (GO:0051823)3.49816410
33dendrite morphogenesis (GO:0048813)3.44284680
34cell migration in hindbrain (GO:0021535)3.38524632
35activation of protein kinase A activity (GO:0034199)3.38472420
36transmission of nerve impulse (GO:0019226)3.38272755
37postsynaptic membrane organization (GO:0001941)3.37500584
38synaptic transmission, glutamatergic (GO:0035249)3.37470875
39presynaptic membrane assembly (GO:0097105)3.36990472
40positive regulation of membrane potential (GO:0045838)3.34370936
41positive regulation by symbiont of host defense response (GO:0052509)3.30018736
42modulation by symbiont of host defense response (GO:0052031)3.30018736
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.30018736
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.30018736
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.30018736
46modulation by symbiont of host immune response (GO:0052553)3.30018736
47G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29154046
48gamma-aminobutyric acid transport (GO:0015812)3.28073600
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.24472551
50neuron-neuron synaptic transmission (GO:0007270)3.23015012
51neurotransmitter transport (GO:0006836)3.21824740
52gamma-aminobutyric acid signaling pathway (GO:0007214)3.20567219
53long-term memory (GO:0007616)3.19948081
54synaptic vesicle endocytosis (GO:0048488)3.18714399
55mating behavior (GO:0007617)3.17251046
56regulation of vesicle fusion (GO:0031338)3.16103266
57regulation of postsynaptic membrane potential (GO:0060078)3.09406627
58regulation of synaptic plasticity (GO:0048167)3.08292944
59vesicle transport along microtubule (GO:0047496)3.08102827
60regulation of dendritic spine morphogenesis (GO:0061001)3.05565213
61response to histamine (GO:0034776)3.05286256
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.04732808
63negative regulation of microtubule polymerization (GO:0031115)3.04057905
64cytoskeletal anchoring at plasma membrane (GO:0007016)3.03551023
65presynaptic membrane organization (GO:0097090)3.03067122
66regulation of neurotransmitter secretion (GO:0046928)3.02193518
67synapse assembly (GO:0007416)3.00927807
68cellular potassium ion homeostasis (GO:0030007)2.99973939
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99925936
70cell-cell junction maintenance (GO:0045217)2.99260915
71organelle transport along microtubule (GO:0072384)2.97855323
72cerebellar granule cell differentiation (GO:0021707)2.97415846
73neurotransmitter-gated ion channel clustering (GO:0072578)2.97181063
74long-term synaptic potentiation (GO:0060291)2.95266497
75inner ear receptor cell development (GO:0060119)2.95170270
76negative regulation of erythrocyte differentiation (GO:0045647)2.94870583
77regulation of mast cell degranulation (GO:0043304)2.91455892
78regulation of neurotransmitter levels (GO:0001505)2.91360223
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.91209631
80cellular response to ammonium ion (GO:0071242)2.90405928
81neuromuscular process controlling balance (GO:0050885)2.89668242
82clathrin coat assembly (GO:0048268)2.88971696
83regulation of leukocyte degranulation (GO:0043300)2.88892419
84regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84991191
85cerebellar Purkinje cell differentiation (GO:0021702)2.83336176
86neuronal ion channel clustering (GO:0045161)2.83286868
87negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83076807
88regulation of dendritic spine development (GO:0060998)2.81571560
89negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80668764
90adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.79959786
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79708743
92regulation of regulated secretory pathway (GO:1903305)2.78749160
93positive regulation of dendritic spine development (GO:0060999)2.78228948
94auditory behavior (GO:0031223)2.77569662
95dopamine receptor signaling pathway (GO:0007212)2.77150467
96central nervous system projection neuron axonogenesis (GO:0021952)2.73603117
97intraspecies interaction between organisms (GO:0051703)2.73462682
98social behavior (GO:0035176)2.73462682
99sensory perception of smell (GO:0007608)2.72242270
100regulation of neurotransmitter transport (GO:0051588)2.71873220
101positive regulation of synapse maturation (GO:0090129)2.71687105
102macrophage activation involved in immune response (GO:0002281)2.71564746
103regulation of ARF protein signal transduction (GO:0032012)2.71526126
104synapse organization (GO:0050808)2.71336598
105neutrophil activation involved in immune response (GO:0002283)2.70654380
106membrane depolarization (GO:0051899)2.70634764
107suckling behavior (GO:0001967)2.70116454
108regulation of synaptic transmission, glutamatergic (GO:0051966)2.69276803
109dendritic spine organization (GO:0097061)2.68594008
110positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.67918048
111learning (GO:0007612)2.67809682
112regulation of glutamate secretion (GO:0014048)2.67695088
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.65437433
114regulation of mast cell activation involved in immune response (GO:0033006)2.65373317
115chemosensory behavior (GO:0007635)2.65286371
116innervation (GO:0060384)2.65081967
117nerve growth factor signaling pathway (GO:0038180)2.64814061
118membrane hyperpolarization (GO:0060081)2.64477901
119positive regulation of neurotransmitter secretion (GO:0001956)2.64452884
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63474723
121regulation of synaptic transmission (GO:0050804)2.63146824
122sodium ion export (GO:0071436)2.62491500
123establishment of mitochondrion localization (GO:0051654)2.61889538
124positive regulation of mast cell activation (GO:0033005)2.61228230
125positive regulation of regulated secretory pathway (GO:1903307)2.59095433
126positive regulation of CREB transcription factor activity (GO:0032793)2.56827467
127positive regulation of mast cell activation involved in immune response (GO:0033008)2.56068876
128positive regulation of mast cell degranulation (GO:0043306)2.56068876
129positive regulation of leukocyte degranulation (GO:0043302)2.54337861
130positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.48583687
131cell junction maintenance (GO:0034331)2.47610096
132regulation of early endosome to late endosome transport (GO:2000641)2.46431216
133positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.46210303
134regulation of ARF GTPase activity (GO:0032312)2.40146765
135regulation of germinal center formation (GO:0002634)2.31748921
136regulation of T-helper 2 cell differentiation (GO:0045628)2.29295521
137signal complex assembly (GO:0007172)2.28413235
138glucocorticoid receptor signaling pathway (GO:0042921)2.25390838
139mesenchymal cell differentiation involved in renal system development (GO:2001012)2.25378606
140mesenchymal cell differentiation involved in kidney development (GO:0072161)2.25378606
141cortical actin cytoskeleton organization (GO:0030866)2.19015079
142endocytic recycling (GO:0032456)2.15057634
143detection of molecule of bacterial origin (GO:0032490)2.14893222
144positive regulation of cellular amide metabolic process (GO:0034250)2.14473633
145regulation of extracellular matrix disassembly (GO:0010715)2.14237079
146response to host defenses (GO:0052200)2.10072729
147response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.10072729
148response to host (GO:0075136)2.10072729
149peptidyl-tyrosine autophosphorylation (GO:0038083)2.07692062
150flavonoid metabolic process (GO:0009812)2.06876132
151endothelial cell chemotaxis (GO:0035767)2.05382840
152embryonic retina morphogenesis in camera-type eye (GO:0060059)2.04803421
153regulation of cholesterol homeostasis (GO:2000188)2.04298952
154positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.02578363
155receptor catabolic process (GO:0032801)2.00957057
156corticosteroid receptor signaling pathway (GO:0031958)1.99434287
157collecting duct development (GO:0072044)1.98210439
158cellular response to nerve growth factor stimulus (GO:1990090)1.97336347
159response to nerve growth factor (GO:1990089)1.97336347
160L-amino acid import (GO:0043092)1.97255861
161semaphorin-plexin signaling pathway (GO:0071526)1.96085338
162cortical cytoskeleton organization (GO:0030865)1.95526917
163positive regulation of receptor recycling (GO:0001921)1.95164690
164response to host immune response (GO:0052572)1.95115912
165response to immune response of other organism involved in symbiotic interaction (GO:0052564)1.95115912
166maternal placenta development (GO:0001893)1.95093113
167positive regulation of Rap GTPase activity (GO:0032854)1.94460205
168microglial cell activation (GO:0001774)1.93765178
169regulation of mast cell activation (GO:0033003)1.92629718
170regulation of interferon-beta biosynthetic process (GO:0045357)1.91461954
171regulation of interferon-gamma biosynthetic process (GO:0045072)1.91453384

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.75955567
2GBX2_23144817_ChIP-Seq_PC3_Human3.09234404
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04430558
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01255826
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88171923
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63508579
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63508579
8REST_21632747_ChIP-Seq_MESCs_Mouse2.59106319
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.58790145
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56344895
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55957282
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50983901
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48068162
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.43997100
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43697122
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41224562
17DROSHA_22980978_ChIP-Seq_HELA_Human2.39737508
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.29166575
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29105546
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.22316455
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.14575246
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.13515528
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10588653
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00795745
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.00612048
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.97616271
27* LXR_22292898_ChIP-Seq_THP-1_Human1.89638849
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88332474
29AR_21572438_ChIP-Seq_LNCaP_Human1.88099102
30TCF7_22412390_ChIP-Seq_EML_Mouse1.83559776
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.81885074
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.81487686
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75444282
34TAF15_26573619_Chip-Seq_HEK293_Human1.75421323
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70520778
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65947205
37KDM2B_26808549_Chip-Seq_DND41_Human1.64791970
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62995116
39* CDX2_20551321_ChIP-Seq_CACO-2_Human1.59650753
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55842645
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55696042
42* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54816605
43* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53700769
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49208302
45MYC_22102868_ChIP-Seq_BL_Human1.46831183
46* GATA1_19941826_ChIP-Seq_K562_Human1.45847636
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45183766
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.44648166
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40238648
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.39894647
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37107584
52* ELK3_25401928_ChIP-Seq_HUVEC_Human1.36283835
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35712941
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.35263324
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.35066551
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34106035
57ZNF274_21170338_ChIP-Seq_K562_Hela1.31101210
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30304088
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29677833
60SCL_19346495_ChIP-Seq_HPC-7_Human1.29659336
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.29039323
62P300_19829295_ChIP-Seq_ESCs_Human1.28533991
63* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28408768
64* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27870827
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25162207
66* RACK7_27058665_Chip-Seq_MCF-7_Human1.24959643
67* SPI1_23127762_ChIP-Seq_K562_Human1.24322668
68* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24053200
69* KDM2B_26808549_Chip-Seq_K562_Human1.22570462
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.22252884
71* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22163506
72* SMAD3_21741376_ChIP-Seq_EPCs_Human1.21918690
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21134756
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20635056
75* SOX2_21211035_ChIP-Seq_LN229_Gbm1.19936375
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19912236
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.19641682
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19490871
79AHR_22903824_ChIP-Seq_MCF-7_Human1.18830297
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18524476
81* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17785616
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17618162
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17578708
84* VDR_21846776_ChIP-Seq_THP-1_Human1.17435110
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.16619458
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16489386
87* FOXA2_19822575_ChIP-Seq_HepG2_Human1.15308050
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14476714
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.14464899
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.14376579
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13477546
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13365112
93WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13326401
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.12077481
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11723221
96SMC4_20622854_ChIP-Seq_HELA_Human1.11710068
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11708461
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10358320
99RNF2_27304074_Chip-Seq_NSC_Mouse1.09634633
100IGF1R_20145208_ChIP-Seq_DFB_Human1.09291460
101AR_25329375_ChIP-Seq_VCAP_Human1.09057411
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08839338
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08764302
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08019725
105* AR_19668381_ChIP-Seq_PC3_Human1.07666016
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07478914
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07406100
108* VDR_24763502_ChIP-Seq_THP-1_Human1.07283657
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06577396
110SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05070789
111* GATA2_19941826_ChIP-Seq_K562_Human1.04479263
112* STAT3_23295773_ChIP-Seq_U87_Human1.04368109
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04223591
114* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03868388
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03653564
116* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03292727
117* RUNX1_27514584_Chip-Seq_MCF-7_Human1.02661396
118CTCF_27219007_Chip-Seq_Bcells_Human1.02160942
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02087489
120CREB1_26743006_Chip-Seq_LNCaP_Human1.02051925
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.01852762
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01614656
123ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00375338
124* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99780193
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99361953
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.98493578
127VDR_22108803_ChIP-Seq_LS180_Human0.97838763
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97441401
129STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97355802
130TRIM28_21343339_ChIP-Seq_HEK293_Human0.96813849
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96737919
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95901776
133* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95830074
134GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94681829
135ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94118776
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94082810
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94082810
138P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93902580
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93214411
140PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92874128
141* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92527139
142* TCF4_23295773_ChIP-Seq_U87_Human0.92151776
143MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91867856
144CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91739288
145SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91172546
146* RUNX2_22187159_ChIP-Seq_PCA_Human0.90191476
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90083225
148NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90065162
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90011554
150RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.88538551
151CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88391124
152GATA2_21666600_ChIP-Seq_HMVEC_Human0.88238597
153SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87366866
154* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87271538
155P68_20966046_ChIP-Seq_HELA_Human0.86989038
156RUNX1_22412390_ChIP-Seq_EML_Mouse0.86847900
157TP53_18474530_ChIP-ChIP_U2OS_Human0.86553182
158RXR_22108803_ChIP-Seq_LS180_Human0.85977229
159* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83165099
160TP53_16413492_ChIP-PET_HCT116_Human0.82426922
161UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82031056
162OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81903845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.84890914
2MP0003880_abnormal_central_pattern4.90195450
3MP0004270_analgesia3.98370978
4MP0003635_abnormal_synaptic_transmissio3.92336132
5MP0009745_abnormal_behavioral_response3.16373037
6MP0002063_abnormal_learning/memory/cond3.15869582
7MP0002064_seizures3.02157532
8MP0001968_abnormal_touch/_nociception2.91225445
9MP0005423_abnormal_somatic_nervous2.77854514
10MP0002734_abnormal_mechanical_nocicepti2.74919187
11MP0002572_abnormal_emotion/affect_behav2.68054603
12MP0009046_muscle_twitch2.62091323
13MP0002735_abnormal_chemical_nociception2.48710627
14MP0001486_abnormal_startle_reflex2.41241991
15MP0002272_abnormal_nervous_system2.37647136
16MP0002089_abnormal_postnatal_growth/wei2.36575456
17MP0001984_abnormal_olfaction2.35148605
18MP0002733_abnormal_thermal_nociception2.34410040
19MP0000778_abnormal_nervous_system2.31611049
20MP0003566_abnormal_cell_adhesion2.30205804
21MP0001501_abnormal_sleep_pattern2.22630130
22MP0006276_abnormal_autonomic_nervous2.21548227
23MP0001440_abnormal_grooming_behavior2.21382585
24MP0003329_amyloid_beta_deposits2.16631586
25MP0002736_abnormal_nociception_after2.15021043
26MP0001970_abnormal_pain_threshold2.14275435
27MP0005076_abnormal_cell_differentiation2.13905378
28MP0004858_abnormal_nervous_system2.09912384
29MP0003436_decreased_susceptibility_to2.01820259
30MP0002822_catalepsy1.98215297
31MP0002184_abnormal_innervation1.98001838
32MP0009780_abnormal_chondrocyte_physiolo1.95142417
33MP0005464_abnormal_platelet_physiology1.94486446
34MP0003705_abnormal_hypodermis_morpholog1.93367055
35MP0005645_abnormal_hypothalamus_physiol1.92373628
36MP0002067_abnormal_sensory_capabilities1.87122924
37MP0002909_abnormal_adrenal_gland1.79667642
38MP0002557_abnormal_social/conspecific_i1.76638438
39MP0004811_abnormal_neuron_physiology1.76305605
40MP0005451_abnormal_body_composition1.72824809
41MP0004924_abnormal_behavior1.65604773
42MP0005386_behavior/neurological_phenoty1.65604773
43MP0000955_abnormal_spinal_cord1.59776135
44MP0004885_abnormal_endolymph1.56554687
45MP0008569_lethality_at_weaning1.56262244
46MP0003300_gastrointestinal_ulcer1.54921483
47MP0000566_synostosis1.54351851
48MP0002882_abnormal_neuron_morphology1.50235825
49MP0003787_abnormal_imprinting1.50216706
50MP0005377_hearing/vestibular/ear_phenot1.46363176
51MP0003878_abnormal_ear_physiology1.46363176
52MP0003123_paternal_imprinting1.45283778
53MP0008004_abnormal_stomach_pH1.40517378
54MP0001905_abnormal_dopamine_level1.40506380
55MP0002066_abnormal_motor_capabilities/c1.40041794
56MP0003122_maternal_imprinting1.39677306
57MP0003879_abnormal_hair_cell1.37673925
58MP0004742_abnormal_vestibular_system1.37419486
59MP0009278_abnormal_bone_marrow1.36652162
60MP0003091_abnormal_cell_migration1.36307917
61MP0004947_skin_inflammation1.33989026
62MP0003724_increased_susceptibility_to1.32333303
63MP0003195_calcinosis1.30085328
64MP0000678_abnormal_parathyroid_gland1.26670621
65MP0003303_peritoneal_inflammation1.25615269
66MP0000920_abnormal_myelination1.23604769
67MP0003633_abnormal_nervous_system1.23188115
68MP0005646_abnormal_pituitary_gland1.22589344
69MP0001529_abnormal_vocalization1.21901269
70MP0001502_abnormal_circadian_rhythm1.21379768
71MP0004142_abnormal_muscle_tone1.20797322
72MP0000534_abnormal_ureter_morphology1.19584190
73MP0002998_abnormal_bone_remodeling1.19443277
74MP0002152_abnormal_brain_morphology1.14832962
75MP0000604_amyloidosis1.11850385
76MP0005409_darkened_coat_color1.10938415
77MP0004510_myositis1.10215226
78MP0001849_ear_inflammation1.09488088
79MP0001188_hyperpigmentation1.09461834
80MP0010329_abnormal_lipoprotein_level1.09187884
81MP0003453_abnormal_keratinocyte_physiol1.08450386
82MP0003634_abnormal_glial_cell1.07790644
83MP0001533_abnormal_skeleton_physiology1.07586221
84MP0003631_nervous_system_phenotype1.02320021
85MP0002229_neurodegeneration1.02230399
86MP0003191_abnormal_cellular_cholesterol1.02185312
87MP0010386_abnormal_urinary_bladder1.00890183
88MP0008961_abnormal_basal_metabolism1.00295207
89MP0001765_abnormal_ion_homeostasis0.99689134
90MP0002419_abnormal_innate_immunity0.99123342
91MP0004264_abnormal_extraembryonic_tissu0.98963437
92MP0005394_taste/olfaction_phenotype0.98029565
93MP0005499_abnormal_olfactory_system0.98029565
94MP0002069_abnormal_eating/drinking_beha0.97533780
95MP0003045_fibrosis0.96168358
96MP0000569_abnormal_digit_pigmentation0.95591001
97MP0008874_decreased_physiological_sensi0.95142200
98MP0002796_impaired_skin_barrier0.95040118
99MP0003690_abnormal_glial_cell0.94432206
100MP0005448_abnormal_energy_balance0.93577785
101MP0003283_abnormal_digestive_organ0.92194816
102MP0008260_abnormal_autophagy0.88359757
103MP0001963_abnormal_hearing_physiology0.86767974
104MP0002752_abnormal_somatic_nervous0.86167096
105MP0000631_abnormal_neuroendocrine_gland0.86007127
106MP0005167_abnormal_blood-brain_barrier0.85920053
107MP0004019_abnormal_vitamin_homeostasis0.85479038
108MP0001851_eye_inflammation0.85041751
109MP0002132_abnormal_respiratory_system0.84638568
110MP0005058_abnormal_lysosome_morphology0.82053150
111MP0008872_abnormal_physiological_respon0.81545662
112MP0001485_abnormal_pinna_reflex0.81337829
113MP0003942_abnormal_urinary_system0.80510278
114MP0005535_abnormal_body_temperature0.80449948
115MP0004130_abnormal_muscle_cell0.80287899
116MP0001348_abnormal_lacrimal_gland0.79301619
117MP0003075_altered_response_to0.78887885
118MP0003866_abnormal_defecation0.75915883
119MP0003172_abnormal_lysosome_physiology0.75506138
120MP0010234_abnormal_vibrissa_follicle0.74639063
121MP0005023_abnormal_wound_healing0.72786972
122MP0004043_abnormal_pH_regulation0.71811138
123MP0001835_abnormal_antigen_presentation0.70175126
124MP0003943_abnormal_hepatobiliary_system0.69533633
125MP0001664_abnormal_digestion0.68876603
126MP0000579_abnormal_nail_morphology0.68370655
127MP0003632_abnormal_nervous_system0.68298914
128MP0005671_abnormal_response_to0.67958661
129MP0002118_abnormal_lipid_homeostasis0.65888883
130MP0005551_abnormal_eye_electrophysiolog0.65291850
131MP0005623_abnormal_meninges_morphology0.65176601
132MP0009115_abnormal_fat_cell0.64850396
133MP0005666_abnormal_adipose_tissue0.62531822
134MP0003861_abnormal_nervous_system0.62031334
135MP0004085_abnormal_heartbeat0.61780901
136MP0001177_atelectasis0.61661034
137MP0002751_abnormal_autonomic_nervous0.61533149
138MP0002638_abnormal_pupillary_reflex0.58932558
139MP0005310_abnormal_salivary_gland0.58452190
140MP0001943_abnormal_respiration0.58136830
141MP0000751_myopathy0.57646176
142MP0002876_abnormal_thyroid_physiology0.55460691
143MP0003183_abnormal_peptide_metabolism0.55347038
144MP0002090_abnormal_vision0.54060680
145MP0000026_abnormal_inner_ear0.53715478
146MP0010769_abnormal_survival0.52753982
147MP0010770_preweaning_lethality0.51878820
148MP0002082_postnatal_lethality0.51878820
149MP0001299_abnormal_eye_distance/0.50474094
150MP0010768_mortality/aging0.48482157

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.20048549
2Myokymia (HP:0002411)6.03894619
3Focal seizures (HP:0007359)5.27977954
4Visual hallucinations (HP:0002367)4.91572830
5Supranuclear gaze palsy (HP:0000605)4.79712400
6Atonic seizures (HP:0010819)4.47467374
7Epileptic encephalopathy (HP:0200134)4.26259387
8Neurofibrillary tangles (HP:0002185)4.03236684
9Cerebral inclusion bodies (HP:0100314)3.93555454
10Absence seizures (HP:0002121)3.91372979
11Hemorrhage of the eye (HP:0011885)3.84373987
12Febrile seizures (HP:0002373)3.79412164
13Progressive cerebellar ataxia (HP:0002073)3.70493282
14Papilledema (HP:0001085)3.67382962
15Mutism (HP:0002300)3.63276969
16Dialeptic seizures (HP:0011146)3.57144924
17Generalized tonic-clonic seizures (HP:0002069)3.55384770
18Limb dystonia (HP:0002451)3.34543147
19Action tremor (HP:0002345)3.32004869
20Prolonged bleeding time (HP:0003010)3.30627179
21Broad-based gait (HP:0002136)3.24901494
22Abnormality of the corticospinal tract (HP:0002492)3.24648015
23Menorrhagia (HP:0000132)3.22599661
24Episodic fever (HP:0001954)3.21465676
25Termporal pattern (HP:0011008)3.19048574
26Insidious onset (HP:0003587)3.19048574
27Amblyopia (HP:0000646)3.17563264
28Ankle clonus (HP:0011448)3.14530112
29Hyperventilation (HP:0002883)3.14513564
30Abnormal eating behavior (HP:0100738)2.96645770
31Abnormality of binocular vision (HP:0011514)2.89368729
32Diplopia (HP:0000651)2.89368729
33Urinary bladder sphincter dysfunction (HP:0002839)2.88225609
34Polyphagia (HP:0002591)2.88020072
35Depression (HP:0000716)2.84722761
36Excessive salivation (HP:0003781)2.84094771
37Drooling (HP:0002307)2.84094771
38Dysmetria (HP:0001310)2.81876318
39Deep venous thrombosis (HP:0002625)2.79830079
40Agitation (HP:0000713)2.79013428
41Poor eye contact (HP:0000817)2.73058889
42Spastic gait (HP:0002064)2.67504274
43Impaired social interactions (HP:0000735)2.67067903
44Abnormal social behavior (HP:0012433)2.67067903
45Anxiety (HP:0000739)2.66153795
46Akinesia (HP:0002304)2.64768671
47Eczematoid dermatitis (HP:0000976)2.63952746
48Genetic anticipation (HP:0003743)2.62779484
49Progressive inability to walk (HP:0002505)2.62516747
50Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.61185087
51Impaired vibration sensation in the lower limbs (HP:0002166)2.59689609
52Abnormality of macrophages (HP:0004311)2.56894493
53Truncal ataxia (HP:0002078)2.55390969
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54562926
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.54562926
56Purpura (HP:0000979)2.53591070
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.50565010
58Broad face (HP:0000283)2.46125033
59Megalencephaly (HP:0001355)2.45482283
60Urinary urgency (HP:0000012)2.42751392
61Epileptiform EEG discharges (HP:0011182)2.39969005
62Stereotypic behavior (HP:0000733)2.39008249
63Apathy (HP:0000741)2.37635886
64Torticollis (HP:0000473)2.37410132
65EEG with generalized epileptiform discharges (HP:0011198)2.35708111
66Absent speech (HP:0001344)2.34917211
67Peritonitis (HP:0002586)2.34696005
68Amyloidosis (HP:0011034)2.32941558
69Dysdiadochokinesis (HP:0002075)2.31667404
70Postural instability (HP:0002172)2.30631292
71Hemiparesis (HP:0001269)2.30089194
72Amyotrophic lateral sclerosis (HP:0007354)2.29334698
73Inappropriate behavior (HP:0000719)2.28111306
74Gaze-evoked nystagmus (HP:0000640)2.25085587
75Epistaxis (HP:0000421)2.25022951
76Hypsarrhythmia (HP:0002521)2.23697969
77Hyperthyroidism (HP:0000836)2.21854289
78Exotropia (HP:0000577)2.20958638
79Retinal dysplasia (HP:0007973)2.20643399
80Bronchomalacia (HP:0002780)2.20177456
81Abnormality of the fingertips (HP:0001211)2.18424860
82Focal dystonia (HP:0004373)2.18020004
83Gingival bleeding (HP:0000225)2.17976773
84Neuronal loss in central nervous system (HP:0002529)2.16867030
85Pheochromocytoma (HP:0002666)2.16508671
86Flat acetabular roof (HP:0003180)2.15088961
87Mitral stenosis (HP:0001718)2.14084800
88Psychosis (HP:0000709)2.14044140
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14028195
90Obstructive sleep apnea (HP:0002870)2.13384224
91Segmental peripheral demyelination/remyelination (HP:0003481)2.12097396
92Cerebral aneurysm (HP:0004944)2.11600618
93Generalized myoclonic seizures (HP:0002123)2.10929863
94Spontaneous hematomas (HP:0007420)2.10240509
95Lower limb muscle weakness (HP:0007340)2.09924465
96Intention tremor (HP:0002080)2.09833698
97Abnormality of salivation (HP:0100755)2.09157993
98Diminished motivation (HP:0000745)2.06381888
99Oligodontia (HP:0000677)2.06313964
100Ankyloglossia (HP:0010296)2.05625282
101Abnormal platelet volume (HP:0011876)2.04977077
102Joint hemorrhage (HP:0005261)2.04476706
103Focal segmental glomerulosclerosis (HP:0000097)2.04246290
104Rapidly progressive (HP:0003678)2.04192372
105Craniofacial dystonia (HP:0012179)2.00360828
106Hypoventilation (HP:0002791)1.97310054
107Abnormality of the nasal septum (HP:0000419)1.97275807
108Bradykinesia (HP:0002067)1.97094836
109Inability to walk (HP:0002540)1.96371323
110Insomnia (HP:0100785)1.94885252
111Decreased central vision (HP:0007663)1.93300683
112Increased IgE level (HP:0003212)1.92711404
113Peripheral hypomyelination (HP:0007182)1.92278115
114Fetal akinesia sequence (HP:0001989)1.92218331
115Striae distensae (HP:0001065)1.91416373
116Failure to thrive in infancy (HP:0001531)1.90793596
117Hypercortisolism (HP:0001578)1.89841481
118Widely spaced teeth (HP:0000687)1.89611176
119Sporadic (HP:0003745)1.89592007
120Impaired smooth pursuit (HP:0007772)1.87832976
121Vascular calcification (HP:0004934)1.84728189
122Open mouth (HP:0000194)1.82495514
123Increased mean platelet volume (HP:0011877)1.81935506
124Hypophosphatemic rickets (HP:0004912)1.80831990
125Osteomalacia (HP:0002749)1.80547770
126Sleep apnea (HP:0010535)1.80224158
127Recurrent pneumonia (HP:0006532)1.80191485
128Hemiplegia (HP:0002301)1.78697547
129Onion bulb formation (HP:0003383)1.78694575
130Neuroendocrine neoplasm (HP:0100634)1.78541683
131Morphological abnormality of the pyramidal tract (HP:0002062)1.78027273
132Blue irides (HP:0000635)1.77991550
133Aqueductal stenosis (HP:0002410)1.77759783
134Gastrointestinal stroma tumor (HP:0100723)1.77491139
135Facial shape deformation (HP:0011334)1.76836032
136Potter facies (HP:0002009)1.76836032
137Arthropathy (HP:0003040)1.76826252
138Poikiloderma (HP:0001029)1.76792519
139Polycythemia (HP:0001901)1.76248154
140Abnormal platelet function (HP:0011869)1.74938408
141Impaired platelet aggregation (HP:0003540)1.74938408
142Macroorchidism (HP:0000053)1.74109587
143Protruding tongue (HP:0010808)1.73741974
144Scanning speech (HP:0002168)1.72591359
145Lower limb amyotrophy (HP:0007210)1.72558574
146Hyperacusis (HP:0010780)1.72057557
147Vertebral arch anomaly (HP:0008438)1.71977467
148Myocardial infarction (HP:0001658)1.71495519
149Autoamputation (HP:0001218)1.71064019
150Renovascular hypertension (HP:0100817)1.67882848
151Arnold-Chiari malformation (HP:0002308)1.67787473
152Malnutrition (HP:0004395)1.67658806
153Petechiae (HP:0000967)1.65471117
154Abnormality of the common coagulation pathway (HP:0010990)1.64093096
155Recurrent sinusitis (HP:0011108)1.62419824
156Systemic lupus erythematosus (HP:0002725)1.61603303
157Zonular cataract (HP:0010920)1.61386982
158Recurrent gram-negative bacterial infections (HP:0005420)1.60625522
159Arterial tortuosity (HP:0005116)1.60448207
160Recurrent bacterial skin infections (HP:0005406)1.60230637
161Dysmetric saccades (HP:0000641)1.60089137
162Aneurysm (HP:0002617)1.59826259
163Thin bony cortex (HP:0002753)1.59067435
164Aseptic necrosis (HP:0010885)1.59032917
165Bowel incontinence (HP:0002607)1.58061298
166Gingivitis (HP:0000230)1.57725585
167Disproportionate tall stature (HP:0001519)1.57199826
168Self-mutilation (HP:0000742)1.56886465
169Ventricular fibrillation (HP:0001663)1.55779104
170Abnormality of incisor morphology (HP:0011063)1.54520154
171Increased density of long bones (HP:0006392)1.53610209
172Choroideremia (HP:0001139)1.53389975
173Cardiovascular calcification (HP:0011915)1.52637724
174Protrusio acetabuli (HP:0003179)1.51661850
175Hypophosphatemia (HP:0002148)1.51535082
176Abnormality of macular pigmentation (HP:0008002)1.50448592
177Bruising susceptibility (HP:0000978)1.50025365
178Broad palm (HP:0001169)1.48910725
179Acanthocytosis (HP:0001927)1.48789896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.09827650
2NTRK33.79346406
3MAP3K93.78380652
4CDK123.59862839
5ERN13.00992319
6EPHA42.85128460
7TRIB32.59695249
8MINK12.58339769
9MAP3K42.51298885
10DAPK22.17571900
11MAP2K72.12808265
12NTRK12.12499205
13PNCK2.12197785
14PAK62.11300154
15SIK22.05147229
16RIPK42.01272872
17NTRK22.01128362
18MAP3K121.99083276
19CASK1.95919464
20KSR21.95739089
21RIPK11.76386135
22FGFR41.75660101
23NEK61.70629431
24SIK11.59918696
25FES1.56373606
26MAPK131.55366847
27MAP3K21.54221735
28MAP2K41.52718649
29UHMK11.51547324
30CDK51.51030830
31GRK51.48978517
32MATK1.47600898
33TNIK1.43937607
34FGFR31.36251763
35CAMKK11.29525070
36KSR11.28151848
37PLK21.24463280
38PHKG21.23588329
39PHKG11.23588329
40TAOK11.21516230
41ARAF1.20315819
42CDK191.18886340
43OXSR11.17661603
44CDC42BPA1.12940623
45DAPK11.11968945
46CSNK1G21.10778901
47TYRO31.09752484
48SGK31.09116311
49PRKD31.08440079
50STK111.07204852
51TAOK31.06280463
52PRPF4B1.05494594
53CAMK1D1.05253987
54SMG11.04966573
55PAK31.02597840
56PRKCG1.02004522
57STK391.00229508
58FGR0.99806883
59MAP3K70.98984954
60CAMK1G0.97510737
61CAMK2A0.95943722
62SGK20.95016823
63BLK0.94792428
64EEF2K0.94482068
65CSK0.93368929
66MARK20.92726359
67CDK140.92092035
68MST1R0.90543376
69CAMK2B0.89173127
70RET0.88265158
71MAP3K130.86214628
72MTOR0.84889669
73CDK150.83204776
74CDK180.82913499
75MAP3K110.82213311
76PKN20.82037254
77LATS20.81547742
78EPHA30.79550662
79PKN10.79203036
80PRKD20.78316177
81PTK60.78221928
82MAP2K30.76187454
83ALK0.75340647
84DYRK1A0.75337533
85MAP2K60.75235697
86MAP3K10.75068090
87ERBB20.74941283
88CDK11A0.74707538
89BMX0.74645591
90WNK40.74592242
91PRKCH0.72841709
92MAPK120.72122250
93SGK2230.71897625
94SGK4940.71897625
95ICK0.70309192
96CSNK1G30.69904020
97ZAP700.69663212
98DYRK20.69452144
99PDGFRA0.68155341
100NME10.67206583
101GRK60.64723500
102MAP3K30.64478557
103IRAK40.63418220
104RPS6KA20.63312553
105FYN0.61569767
106PRKCZ0.61512088
107CAMKK20.60707179
108PTK2B0.60568777
109GRK70.60463306
110MAP4K10.59912357
111PDPK10.59739227
112PTK20.59124756
113CAMK10.59103324
114SGK10.58519834
115TYK20.58265052
116BRD40.56694723
117CSNK1A1L0.56375012
118BMPR20.55739125
119EPHA20.55187051
120CAMK2D0.54968080
121PDGFRB0.54126491
122PRKCE0.54039828
123SYK0.52615082
124RAF10.52473130
125IRAK30.51277881
126PRKG20.51191925
127CAMK40.50859432
128TNK20.50439178
129STK380.50170167
130PDK10.49911096
131ROCK20.49275569
132CSF1R0.48698147
133HCK0.47793306
134BTK0.47494287
135LIMK10.45915774
136DDR20.45558214
137JAK20.45550308
138JAK10.43972152
139EPHB20.43898732
140WNK10.43369252
141FER0.43352165
142HIPK20.42671865
143CAMK2G0.39824872
144BCR0.38058567
145DMPK0.37848637
146CSNK1G10.37832871
147RPS6KA30.35899658
148EPHB10.35514630
149MAP3K60.35355454
150MAPK100.35225819

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.99981478
2Synaptic vesicle cycle_Homo sapiens_hsa047212.93391971
3Olfactory transduction_Homo sapiens_hsa047402.81936813
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.54301945
5GABAergic synapse_Homo sapiens_hsa047272.34151274
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33518103
7Long-term potentiation_Homo sapiens_hsa047202.29095363
8Glutamatergic synapse_Homo sapiens_hsa047242.26767225
9Circadian entrainment_Homo sapiens_hsa047132.26076937
10Morphine addiction_Homo sapiens_hsa050322.21676487
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14059341
12Amphetamine addiction_Homo sapiens_hsa050312.07246983
13Dopaminergic synapse_Homo sapiens_hsa047282.05201428
14Salivary secretion_Homo sapiens_hsa049701.93005206
15Cholinergic synapse_Homo sapiens_hsa047251.86386811
16Insulin secretion_Homo sapiens_hsa049111.82072315
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75484967
18Serotonergic synapse_Homo sapiens_hsa047261.74628984
19Gastric acid secretion_Homo sapiens_hsa049711.73918370
20Collecting duct acid secretion_Homo sapiens_hsa049661.66353905
21Cocaine addiction_Homo sapiens_hsa050301.63788245
22Renin secretion_Homo sapiens_hsa049241.63376043
23Taste transduction_Homo sapiens_hsa047421.63105285
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61857838
25Long-term depression_Homo sapiens_hsa047301.61517401
26Axon guidance_Homo sapiens_hsa043601.50886629
27Oxytocin signaling pathway_Homo sapiens_hsa049211.43728230
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41267679
29GnRH signaling pathway_Homo sapiens_hsa049121.40167225
30Gap junction_Homo sapiens_hsa045401.32972920
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30508414
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29495452
33Notch signaling pathway_Homo sapiens_hsa043301.28630804
34Estrogen signaling pathway_Homo sapiens_hsa049151.26864318
35Vibrio cholerae infection_Homo sapiens_hsa051101.22820960
36Type II diabetes mellitus_Homo sapiens_hsa049301.22701231
37Calcium signaling pathway_Homo sapiens_hsa040201.21838799
38Platelet activation_Homo sapiens_hsa046111.17928070
39Glioma_Homo sapiens_hsa052141.17010525
40ErbB signaling pathway_Homo sapiens_hsa040121.15666730
41cAMP signaling pathway_Homo sapiens_hsa040241.14126340
42Osteoclast differentiation_Homo sapiens_hsa043801.08519318
43Dorso-ventral axis formation_Homo sapiens_hsa043201.08035199
44Melanogenesis_Homo sapiens_hsa049161.04438676
45Acute myeloid leukemia_Homo sapiens_hsa052211.00484628
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99041283
47Chronic myeloid leukemia_Homo sapiens_hsa052200.98874007
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97898426
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93040937
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92193193
51Adherens junction_Homo sapiens_hsa045200.90028343
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89344716
53Pancreatic cancer_Homo sapiens_hsa052120.89223288
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88826878
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.87969876
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86816076
57Staphylococcus aureus infection_Homo sapiens_hsa051500.83696966
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82953366
59Pancreatic secretion_Homo sapiens_hsa049720.82783104
60Choline metabolism in cancer_Homo sapiens_hsa052310.82287242
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.82127083
62Renal cell carcinoma_Homo sapiens_hsa052110.82029162
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.80480702
64MAPK signaling pathway_Homo sapiens_hsa040100.78843096
65VEGF signaling pathway_Homo sapiens_hsa043700.78535855
66Phototransduction_Homo sapiens_hsa047440.77267273
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.76744280
68Leishmaniasis_Homo sapiens_hsa051400.75519852
69Cardiac muscle contraction_Homo sapiens_hsa042600.75065713
70Amoebiasis_Homo sapiens_hsa051460.74487144
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74010628
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73692573
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.73036776
74Thyroid hormone synthesis_Homo sapiens_hsa049180.72176776
75Tuberculosis_Homo sapiens_hsa051520.70694037
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70355065
77Ras signaling pathway_Homo sapiens_hsa040140.69811026
78HIF-1 signaling pathway_Homo sapiens_hsa040660.69506578
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.69094679
80FoxO signaling pathway_Homo sapiens_hsa040680.68758647
81Alzheimers disease_Homo sapiens_hsa050100.66190134
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65468601
83Insulin resistance_Homo sapiens_hsa049310.65048230
84Complement and coagulation cascades_Homo sapiens_hsa046100.63666871
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.63461714
86Chemokine signaling pathway_Homo sapiens_hsa040620.62701882
87Endocytosis_Homo sapiens_hsa041440.62655506
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61577351
89Endometrial cancer_Homo sapiens_hsa052130.61475514
90Hepatitis C_Homo sapiens_hsa051600.61107881
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60253184
92Glycerolipid metabolism_Homo sapiens_hsa005610.59930146
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59877572
94Focal adhesion_Homo sapiens_hsa045100.59447043
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58782522
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58634833
97Thyroid cancer_Homo sapiens_hsa052160.58015456
98Rap1 signaling pathway_Homo sapiens_hsa040150.57957178
99Proteoglycans in cancer_Homo sapiens_hsa052050.56926950
100Inositol phosphate metabolism_Homo sapiens_hsa005620.56577526
101TNF signaling pathway_Homo sapiens_hsa046680.55483483
102Oocyte meiosis_Homo sapiens_hsa041140.55429219
103Prion diseases_Homo sapiens_hsa050200.55407783
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54515098
105Toxoplasmosis_Homo sapiens_hsa051450.54020207
106Type I diabetes mellitus_Homo sapiens_hsa049400.52538904
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51231402
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51091743
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49079636
110Non-small cell lung cancer_Homo sapiens_hsa052230.47429538
111T cell receptor signaling pathway_Homo sapiens_hsa046600.47015380
112Oxidative phosphorylation_Homo sapiens_hsa001900.46139439
113Dilated cardiomyopathy_Homo sapiens_hsa054140.45263157
114mTOR signaling pathway_Homo sapiens_hsa041500.44716419
115Rheumatoid arthritis_Homo sapiens_hsa053230.44187963
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43979336
117Wnt signaling pathway_Homo sapiens_hsa043100.43185966
118Colorectal cancer_Homo sapiens_hsa052100.42895914
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42445738
120African trypanosomiasis_Homo sapiens_hsa051430.42105406
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41502606
122Insulin signaling pathway_Homo sapiens_hsa049100.40734098
123Alcoholism_Homo sapiens_hsa050340.40596756
124Prolactin signaling pathway_Homo sapiens_hsa049170.40550254
125B cell receptor signaling pathway_Homo sapiens_hsa046620.40540686
126Ovarian steroidogenesis_Homo sapiens_hsa049130.40462734
127Bile secretion_Homo sapiens_hsa049760.38878573
128Phagosome_Homo sapiens_hsa041450.38672404
129Salmonella infection_Homo sapiens_hsa051320.37809207
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37752199
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37436784

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