CLUAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intraciliary transport (GO:0042073)4.57213531
2cilium movement (GO:0003341)4.51094133
3ribosomal small subunit assembly (GO:0000028)4.49630233
4axonemal dynein complex assembly (GO:0070286)4.42696720
5behavioral response to nicotine (GO:0035095)4.30996167
6regulation of cilium movement (GO:0003352)4.29802915
7cilium or flagellum-dependent cell motility (GO:0001539)4.03100768
8epithelial cilium movement (GO:0003351)3.99473113
9GTP biosynthetic process (GO:0006183)3.95394702
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.95394580
11mitochondrial respiratory chain complex I assembly (GO:0032981)3.95394580
12NADH dehydrogenase complex assembly (GO:0010257)3.95394580
13piRNA metabolic process (GO:0034587)3.91886403
14nonmotile primary cilium assembly (GO:0035058)3.91144779
15viral mRNA export from host cell nucleus (GO:0046784)3.86580329
16protein polyglutamylation (GO:0018095)3.78172165
17protein localization to cilium (GO:0061512)3.72310427
18protein complex biogenesis (GO:0070271)3.70095694
19mitochondrial respiratory chain complex assembly (GO:0033108)3.57297313
20histone H2A acetylation (GO:0043968)3.53744750
21DNA deamination (GO:0045006)3.52940586
22guanosine-containing compound biosynthetic process (GO:1901070)3.51672752
23UTP biosynthetic process (GO:0006228)3.50145911
24centriole replication (GO:0007099)3.48847461
25regulation of microtubule-based movement (GO:0060632)3.41219663
26left/right axis specification (GO:0070986)3.41179693
27synapsis (GO:0007129)3.40289003
28motile cilium assembly (GO:0044458)3.38508825
29intra-S DNA damage checkpoint (GO:0031573)3.37032429
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36446894
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.34519057
32left/right pattern formation (GO:0060972)3.32391116
33* cellular component assembly involved in morphogenesis (GO:0010927)3.32240906
34CTP biosynthetic process (GO:0006241)3.29063533
35CTP metabolic process (GO:0046036)3.29063533
36response to pheromone (GO:0019236)3.26293527
37pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.24375564
38DNA methylation involved in gamete generation (GO:0043046)3.21312035
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19840705
40maturation of SSU-rRNA (GO:0030490)3.19437288
41ventricular system development (GO:0021591)3.17083396
42viral transcription (GO:0019083)3.16040906
43male meiosis (GO:0007140)3.15874759
44fucose catabolic process (GO:0019317)3.15821784
45L-fucose metabolic process (GO:0042354)3.15821784
46L-fucose catabolic process (GO:0042355)3.15821784
47cotranslational protein targeting to membrane (GO:0006613)3.15628193
48ATP synthesis coupled proton transport (GO:0015986)3.14847077
49energy coupled proton transport, down electrochemical gradient (GO:0015985)3.14847077
50retinal cone cell development (GO:0046549)3.12987704
51smoothened signaling pathway (GO:0007224)3.10560266
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.09858051
53protein targeting to ER (GO:0045047)3.08610510
54male meiosis I (GO:0007141)3.08464437
55ribosomal small subunit biogenesis (GO:0042274)3.08101760
56telomere maintenance via semi-conservative replication (GO:0032201)3.07228249
57pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.05689519
58translational termination (GO:0006415)3.05620738
59termination of RNA polymerase III transcription (GO:0006386)3.04214657
60transcription elongation from RNA polymerase III promoter (GO:0006385)3.04214657
61nucleoside diphosphate phosphorylation (GO:0006165)3.02985633
62microtubule bundle formation (GO:0001578)3.02183573
637-methylguanosine mRNA capping (GO:0006370)3.01729730
64RNA capping (GO:0036260)3.01546577
657-methylguanosine RNA capping (GO:0009452)3.01546577
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.00650712
67pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.00303165
68centriole assembly (GO:0098534)2.98976795
69photoreceptor cell maintenance (GO:0045494)2.96793802
70regulation of meiosis I (GO:0060631)2.96114328
71UTP metabolic process (GO:0046051)2.95955083
72pyrimidine nucleobase catabolic process (GO:0006208)2.95785043
73presynaptic membrane assembly (GO:0097105)2.95471066
74sperm motility (GO:0030317)2.93144116
75* cilium organization (GO:0044782)2.92552885
76telomere maintenance via recombination (GO:0000722)2.92270284
77* cilium assembly (GO:0042384)2.91985103
78protein localization to endoplasmic reticulum (GO:0070972)2.91905903
79establishment of protein localization to endoplasmic reticulum (GO:0072599)2.91539745
80cornea development in camera-type eye (GO:0061303)2.91198581
81DNA strand elongation (GO:0022616)2.88891285
82transmission of nerve impulse (GO:0019226)2.88761655
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88657598
84postsynaptic membrane organization (GO:0001941)2.87887297
85axoneme assembly (GO:0035082)2.87263970
86translational elongation (GO:0006414)2.84556497
87DNA strand elongation involved in DNA replication (GO:0006271)2.83182059
88platelet dense granule organization (GO:0060155)2.83175733
89acrosome reaction (GO:0007340)2.81292739
90ribosomal large subunit biogenesis (GO:0042273)2.80140535
91sperm-egg recognition (GO:0035036)2.80125715
92neural tube formation (GO:0001841)2.76141698
93determination of left/right symmetry (GO:0007368)2.75869555
94mitotic recombination (GO:0006312)2.75819594
95limb development (GO:0060173)2.74143767
96appendage development (GO:0048736)2.74143767
97spliceosomal complex assembly (GO:0000245)2.71936626
98DNA replication initiation (GO:0006270)2.70955188
99reciprocal DNA recombination (GO:0035825)2.69554733
100reciprocal meiotic recombination (GO:0007131)2.69554733
101spermatid development (GO:0007286)2.68361881
1022-deoxyribonucleotide biosynthetic process (GO:0009265)2.67990588
103deoxyribose phosphate biosynthetic process (GO:0046385)2.67990588
104pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.67514585
105fusion of sperm to egg plasma membrane (GO:0007342)2.66363861
106pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.66268722
107RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.65585062
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.65585062
109binding of sperm to zona pellucida (GO:0007339)2.65262593
110formation of translation preinitiation complex (GO:0001731)2.64752698
111spliceosomal snRNP assembly (GO:0000387)2.63919575
112behavioral response to ethanol (GO:0048149)2.63695159
113kidney morphogenesis (GO:0060993)2.63482379
114pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.62775215
115multicellular organism reproduction (GO:0032504)2.59820211
116determination of bilateral symmetry (GO:0009855)2.59766428
117cullin deneddylation (GO:0010388)2.59723658
118presynaptic membrane organization (GO:0097090)2.58786375
119microtubule depolymerization (GO:0007019)2.58176760
120cellular ketone body metabolic process (GO:0046950)2.58134881
121DNA unwinding involved in DNA replication (GO:0006268)2.57502064
122* cell projection assembly (GO:0030031)2.57436349
123spinal cord motor neuron differentiation (GO:0021522)2.56574552
124cellular protein complex disassembly (GO:0043624)2.56218293
125regulation of action potential (GO:0098900)2.55453846
126translation (GO:0006412)2.54930221
127regulation of collateral sprouting (GO:0048670)2.54066397
128cellular component biogenesis (GO:0044085)2.53948926
129positive regulation of meiosis (GO:0045836)2.53841484
130telomere maintenance via telomere lengthening (GO:0010833)2.53396326
131specification of symmetry (GO:0009799)2.52852076
132establishment of integrated proviral latency (GO:0075713)2.52502417
133cell-cell recognition (GO:0009988)2.52442596
134base-excision repair, AP site formation (GO:0006285)2.51644922
135nucleobase catabolic process (GO:0046113)2.51396700
136cilium morphogenesis (GO:0060271)2.50405781
137synaptic vesicle docking involved in exocytosis (GO:0016081)2.49959579
138pseudouridine synthesis (GO:0001522)2.49447715
139establishment of protein localization to mitochondrial membrane (GO:0090151)2.48729006
140negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.48294398
141auditory behavior (GO:0031223)2.47975016
142startle response (GO:0001964)2.47958792
143viral life cycle (GO:0019058)2.47843527
144nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.47564471
145mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.47439701
146transcription-coupled nucleotide-excision repair (GO:0006283)2.47301944
147CENP-A containing nucleosome assembly (GO:0034080)2.47140260
148photoreceptor cell development (GO:0042461)2.47096701
149plasma membrane fusion (GO:0045026)2.46699892
150negative regulation of telomere maintenance (GO:0032205)2.46699753
151respiratory chain complex IV assembly (GO:0008535)2.46592335
152iron-sulfur cluster assembly (GO:0016226)2.45924289
153metallo-sulfur cluster assembly (GO:0031163)2.45924289
154organelle disassembly (GO:1903008)2.45568533
155pyrimidine nucleotide biosynthetic process (GO:0006221)2.45444976
156detection of light stimulus involved in sensory perception (GO:0050962)2.43543260
157detection of light stimulus involved in visual perception (GO:0050908)2.43543260
158tongue development (GO:0043586)2.41815331
159ribonucleoprotein complex biogenesis (GO:0022613)2.41475130
160microtubule-based movement (GO:0007018)2.41198213
161negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41044717
162somite development (GO:0061053)2.40956112
163chromosome organization involved in meiosis (GO:0070192)2.38709246
164positive regulation of meiotic cell cycle (GO:0051446)2.38590453
165inner ear receptor stereocilium organization (GO:0060122)2.36883460
166indolalkylamine metabolic process (GO:0006586)2.33722216
167retinal ganglion cell axon guidance (GO:0031290)2.33185517
168mechanosensory behavior (GO:0007638)2.32937953
169ketone body metabolic process (GO:1902224)2.32161827
170limb bud formation (GO:0060174)2.31532962
171negative regulation of transcription regulatory region DNA binding (GO:2000678)2.31345833
172resolution of meiotic recombination intermediates (GO:0000712)2.30297272
173eye photoreceptor cell development (GO:0042462)2.25451613
174regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.25194042
175G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.23034804
176meiosis I (GO:0007127)2.22796989
177membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.21282955
178DNA double-strand break processing (GO:0000729)2.20413155
179neuron cell-cell adhesion (GO:0007158)2.19875728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.76371658
2E2F7_22180533_ChIP-Seq_HELA_Human3.66416742
3EZH2_22144423_ChIP-Seq_EOC_Human3.64327342
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43429279
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.28781188
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.23287854
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.09589439
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04509059
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.98089509
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.93646585
11VDR_22108803_ChIP-Seq_LS180_Human2.85930456
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.84135667
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.83212571
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58723155
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.54617472
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.54222941
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.46820616
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45183935
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43147128
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41454052
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30423220
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09208110
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.09064220
24P300_19829295_ChIP-Seq_ESCs_Human2.08061292
25VDR_23849224_ChIP-Seq_CD4+_Human2.06070252
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05461836
27FOXP3_21729870_ChIP-Seq_TREG_Human2.01363547
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.99885127
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98282271
30* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.97443823
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93504686
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87208313
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86413016
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.86276206
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82043242
36ER_23166858_ChIP-Seq_MCF-7_Human1.81362523
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78233127
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.76148712
39SMAD4_21799915_ChIP-Seq_A2780_Human1.76121446
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73061056
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72637502
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71652065
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71238347
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71177286
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71069494
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66975801
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66877172
48* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64850117
49GBX2_23144817_ChIP-Seq_PC3_Human1.64593156
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.64047466
51STAT3_23295773_ChIP-Seq_U87_Human1.62071338
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60303338
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59983555
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.57695171
55BCAT_22108803_ChIP-Seq_LS180_Human1.57687809
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57678560
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56782828
58AR_25329375_ChIP-Seq_VCAP_Human1.56261800
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.55895230
60CBP_20019798_ChIP-Seq_JUKART_Human1.53829125
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53829125
62* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53274828
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53031141
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52372904
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52372904
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52340001
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52325884
68ELK1_19687146_ChIP-ChIP_HELA_Human1.52256323
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.50985037
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50588736
71* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49870036
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48915324
73TTF2_22483619_ChIP-Seq_HELA_Human1.48479957
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46877432
75XRN2_22483619_ChIP-Seq_HELA_Human1.46670062
76TCF4_23295773_ChIP-Seq_U87_Human1.45638296
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45188386
78AR_21572438_ChIP-Seq_LNCaP_Human1.43977954
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43220357
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41561046
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39373060
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38119213
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36618359
84DCP1A_22483619_ChIP-Seq_HELA_Human1.36325043
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35283261
86GABP_19822575_ChIP-Seq_HepG2_Human1.33374490
87RUNX2_22187159_ChIP-Seq_PCA_Human1.31972066
88FUS_26573619_Chip-Seq_HEK293_Human1.30739853
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28840899
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27778004
91TP53_22573176_ChIP-Seq_HFKS_Human1.27689801
92* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26661907
93TCF4_22108803_ChIP-Seq_LS180_Human1.25588255
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.24181548
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23619610
96NANOG_19829295_ChIP-Seq_ESCs_Human1.23458796
97SOX2_19829295_ChIP-Seq_ESCs_Human1.23458796
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23163074
99MYC_18940864_ChIP-ChIP_HL60_Human1.22540384
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22389256
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20391970
102EWS_26573619_Chip-Seq_HEK293_Human1.20286427
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20027561
104E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15851687
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14390464
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13267747
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12909101
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11890850
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.11845408
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.11554239
111SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11443513
112EED_16625203_ChIP-ChIP_MESCs_Mouse1.09497074
113EZH2_27304074_Chip-Seq_ESCs_Mouse1.09384159
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07636735
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07213799
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.07213799
117TP53_16413492_ChIP-PET_HCT116_Human1.07175292
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06614189
119ZNF274_21170338_ChIP-Seq_K562_Hela1.05554046
120IGF1R_20145208_ChIP-Seq_DFB_Human1.05542230
121DROSHA_22980978_ChIP-Seq_HELA_Human1.05280893
122POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05005073
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.04792607
124JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03297387
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.03186477
126IRF1_19129219_ChIP-ChIP_H3396_Human1.02991365
127CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02420395
128NCOR_22424771_ChIP-Seq_293T_Human1.02197608
129ARNT_22903824_ChIP-Seq_MCF-7_Human1.02131393
130SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01698069
131CBX2_27304074_Chip-Seq_ESCs_Mouse1.01638836
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01523491
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01326138
134BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00435884
135TAF15_26573619_Chip-Seq_HEK293_Human1.00261418
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.99828566
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99158586
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98868074
139FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98792997
140CIITA_25753668_ChIP-Seq_RAJI_Human0.98658667
141PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98613328
142* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98337265
143* SOX2_21211035_ChIP-Seq_LN229_Gbm0.97940687
144* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97781765
145SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96402472
146NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96023833
147FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95645037
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95278998
149CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94847827
150RNF2_27304074_Chip-Seq_NSC_Mouse0.94082551
151FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91352325
152E2F1_21310950_ChIP-Seq_MCF-7_Human0.91074803
153* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89862167
154SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88710835
155IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87443427
156CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86097716
157* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85587334
158REST_21632747_ChIP-Seq_MESCs_Mouse0.85093850
159CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84251620
160POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83574145
161RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82488068
162MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.81550853
163GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81542927
164STAT3_18555785_Chip-Seq_ESCs_Mouse0.81232361
165NANOG_18555785_Chip-Seq_ESCs_Mouse0.79867738
166TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79816642
167ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79748841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.21829999
2MP0008058_abnormal_DNA_repair2.98049440
3MP0010094_abnormal_chromosome_stability2.55617801
4MP0008877_abnormal_DNA_methylation2.55061612
5MP0001188_hyperpigmentation2.54108665
6MP0005410_abnormal_fertilization2.52614371
7MP0001984_abnormal_olfaction2.37408402
8MP0008057_abnormal_DNA_replication2.31086571
9MP0006292_abnormal_olfactory_placode2.11856259
10MP0005551_abnormal_eye_electrophysiolog2.07497695
11MP0003763_abnormal_thymus_physiology1.91637634
12MP0001529_abnormal_vocalization1.89930622
13MP0005423_abnormal_somatic_nervous1.86144560
14MP0001968_abnormal_touch/_nociception1.85650595
15MP0006072_abnormal_retinal_apoptosis1.84631354
16MP0003693_abnormal_embryo_hatching1.84491960
17MP0009379_abnormal_foot_pigmentation1.84440562
18MP0002736_abnormal_nociception_after1.83673267
19MP0000569_abnormal_digit_pigmentation1.82218633
20MP0003787_abnormal_imprinting1.80719501
21MP0004133_heterotaxia1.79395311
22MP0002396_abnormal_hematopoietic_system1.78869055
23MP0002837_dystrophic_cardiac_calcinosis1.78461411
24MP0001485_abnormal_pinna_reflex1.78090589
25MP0005645_abnormal_hypothalamus_physiol1.75449842
26MP0004859_abnormal_synaptic_plasticity1.74887367
27MP0005075_abnormal_melanosome_morpholog1.71708789
28MP0005671_abnormal_response_to1.70279833
29MP0005174_abnormal_tail_pigmentation1.64961288
30MP0003635_abnormal_synaptic_transmissio1.61299605
31MP0003195_calcinosis1.59033595
32MP0003077_abnormal_cell_cycle1.58432035
33MP0008004_abnormal_stomach_pH1.56912251
34MP0000015_abnormal_ear_pigmentation1.56864240
35MP0000778_abnormal_nervous_system1.54970356
36MP0004043_abnormal_pH_regulation1.54934889
37MP0001929_abnormal_gametogenesis1.54867971
38MP0002095_abnormal_skin_pigmentation1.54788804
39MP0003698_abnormal_male_reproductive1.54615776
40MP0009745_abnormal_behavioral_response1.52502921
41MP0004885_abnormal_endolymph1.50489837
42MP0005646_abnormal_pituitary_gland1.49894538
43MP0009046_muscle_twitch1.46928779
44MP0003111_abnormal_nucleus_morphology1.46227788
45MP0008875_abnormal_xenobiotic_pharmacok1.44856165
46MP0000427_abnormal_hair_cycle1.43189310
47MP0002572_abnormal_emotion/affect_behav1.41135934
48MP0002272_abnormal_nervous_system1.40683502
49MP0001986_abnormal_taste_sensitivity1.40622383
50MP0002938_white_spotting1.39457169
51MP0003122_maternal_imprinting1.33882959
52MP0009780_abnormal_chondrocyte_physiolo1.30454307
53MP0002102_abnormal_ear_morphology1.28052758
54MP0008872_abnormal_physiological_respon1.27780857
55MP0000372_irregular_coat_pigmentation1.27491105
56MP0005377_hearing/vestibular/ear_phenot1.27018224
57MP0003878_abnormal_ear_physiology1.27018224
58MP0002064_seizures1.26183406
59MP0006035_abnormal_mitochondrial_morpho1.25756116
60MP0004808_abnormal_hematopoietic_stem1.25713588
61MP0008007_abnormal_cellular_replicative1.25702380
62MP0003786_premature_aging1.23906372
63MP0005389_reproductive_system_phenotype1.23288222
64MP0002063_abnormal_learning/memory/cond1.21979712
65MP0004142_abnormal_muscle_tone1.19364414
66MP0002638_abnormal_pupillary_reflex1.18687366
67MP0004957_abnormal_blastocyst_morpholog1.17487496
68MP0002557_abnormal_social/conspecific_i1.16120388
69MP0002928_abnormal_bile_duct1.15964062
70MP0005409_darkened_coat_color1.14970373
71MP0002822_catalepsy1.14541263
72MP0010386_abnormal_urinary_bladder1.13811669
73MP0001486_abnormal_startle_reflex1.12234751
74MP0002210_abnormal_sex_determination1.11577637
75MP0001905_abnormal_dopamine_level1.10121332
76MP0000026_abnormal_inner_ear1.09944120
77MP0005379_endocrine/exocrine_gland_phen1.09775620
78MP0001293_anophthalmia1.09433754
79MP0003646_muscle_fatigue1.09192603
80MP0002734_abnormal_mechanical_nocicepti1.08601132
81MP0005187_abnormal_penis_morphology1.07721198
82MP0005253_abnormal_eye_physiology1.07354019
83MP0000383_abnormal_hair_follicle1.06687280
84MP0005195_abnormal_posterior_eye1.06016714
85MP0006036_abnormal_mitochondrial_physio1.05079850
86MP0000631_abnormal_neuroendocrine_gland1.04956295
87MP0002735_abnormal_chemical_nociception1.04896326
88MP0004924_abnormal_behavior1.04407990
89MP0005386_behavior/neurological_phenoty1.04407990
90MP0001501_abnormal_sleep_pattern1.03276661
91MP0003121_genomic_imprinting1.03266481
92MP0002233_abnormal_nose_morphology1.03058479
93MP0003011_delayed_dark_adaptation1.01246981
94MP0002067_abnormal_sensory_capabilities1.00968864
95MP0003866_abnormal_defecation1.00952105
96MP0008789_abnormal_olfactory_epithelium1.00870078
97MP0008932_abnormal_embryonic_tissue1.00659791
98MP0003937_abnormal_limbs/digits/tail_de1.00256049
99MP0009697_abnormal_copulation0.99791680
100MP0003718_maternal_effect0.99018393
101MP0003890_abnormal_embryonic-extraembry0.98866089
102MP0000703_abnormal_thymus_morphology0.98831041
103MP0001963_abnormal_hearing_physiology0.97143996
104MP0002184_abnormal_innervation0.96378846
105MP0004147_increased_porphyrin_level0.96147353
106MP0000566_synostosis0.94222910
107MP0002234_abnormal_pharynx_morphology0.93910293
108MP0000653_abnormal_sex_gland0.93668839
109MP0001145_abnormal_male_reproductive0.91978978
110MP0001502_abnormal_circadian_rhythm0.91945388
111MP0002909_abnormal_adrenal_gland0.91722816
112MP0005084_abnormal_gallbladder_morpholo0.91534231
113MP0005499_abnormal_olfactory_system0.91376220
114MP0005394_taste/olfaction_phenotype0.91376220
115MP0002160_abnormal_reproductive_system0.91361644
116MP0005391_vision/eye_phenotype0.91223861
117MP0008995_early_reproductive_senescence0.91219088
118MP0000955_abnormal_spinal_cord0.90329149
119MP0002277_abnormal_respiratory_mucosa0.88677667
120MP0004742_abnormal_vestibular_system0.88376589
121MP0001835_abnormal_antigen_presentation0.87984292
122MP0002163_abnormal_gland_morphology0.86803568
123MP0001970_abnormal_pain_threshold0.85304390
124MP0002398_abnormal_bone_marrow0.84740501
125MP0006054_spinal_hemorrhage0.84294065
126MP0002161_abnormal_fertility/fecundity0.83942383
127MP0004811_abnormal_neuron_physiology0.83912115
128MP0001873_stomach_inflammation0.83382719
129MP0003136_yellow_coat_color0.83379820
130MP0008569_lethality_at_weaning0.82858849
131MP0000465_gastrointestinal_hemorrhage0.80462864
132MP0006276_abnormal_autonomic_nervous0.80398921
133MP0002653_abnormal_ependyma_morphology0.80185261
134MP0002132_abnormal_respiratory_system0.79734108
135MP0000358_abnormal_cell_content/0.79647912
136MP0002752_abnormal_somatic_nervous0.79317738
137MP0000049_abnormal_middle_ear0.79278224
138MP0004215_abnormal_myocardial_fiber0.78242468
139MP0002229_neurodegeneration0.77886247
140MP0001664_abnormal_digestion0.77597969
141MP0002882_abnormal_neuron_morphology0.76246242
142MP0003315_abnormal_perineum_morphology0.76060992
143MP0000313_abnormal_cell_death0.74837252
144MP0002876_abnormal_thyroid_physiology0.74780456

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.15776142
2Abnormal respiratory motile cilium physiology (HP:0012261)5.04118810
3Abnormal ciliary motility (HP:0012262)4.97547991
4Medial flaring of the eyebrow (HP:0010747)4.35468019
5Pancreatic fibrosis (HP:0100732)4.34491342
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.34345445
7Absent/shortened dynein arms (HP:0200106)4.34345445
8Abnormal respiratory epithelium morphology (HP:0012253)4.23925819
9Abnormal respiratory motile cilium morphology (HP:0005938)4.23925819
10True hermaphroditism (HP:0010459)3.93319441
11Rhinitis (HP:0012384)3.79740538
12Acute necrotizing encephalopathy (HP:0006965)3.74410840
13Gait imbalance (HP:0002141)3.71618337
14Congenital primary aphakia (HP:0007707)3.65155742
15Abnormal mitochondria in muscle tissue (HP:0008316)3.58745585
16Nephrogenic diabetes insipidus (HP:0009806)3.58303906
17Pancreatic cysts (HP:0001737)3.57572605
18Aplastic anemia (HP:0001915)3.41832687
19Chronic hepatic failure (HP:0100626)3.33695420
20Panhypogammaglobulinemia (HP:0003139)3.18595001
21Nephronophthisis (HP:0000090)3.16364663
22Progressive macrocephaly (HP:0004481)3.10028619
23Mitochondrial inheritance (HP:0001427)3.09141759
24Abnormality of midbrain morphology (HP:0002418)3.03597078
25Molar tooth sign on MRI (HP:0002419)3.03597078
26Increased CSF lactate (HP:0002490)2.89524001
27Abnormality of the renal cortex (HP:0011035)2.88868745
28Chronic bronchitis (HP:0004469)2.75374660
29Hepatocellular necrosis (HP:0001404)2.72514954
30Abnormality of cells of the erythroid lineage (HP:0012130)2.72111355
31Type 2 muscle fiber atrophy (HP:0003554)2.71283160
32Sclerocornea (HP:0000647)2.70103675
33Abnormal number of erythroid precursors (HP:0012131)2.64795759
34Tubular atrophy (HP:0000092)2.62981633
35Acute encephalopathy (HP:0006846)2.61620478
36Bronchiectasis (HP:0002110)2.57767443
37Central scotoma (HP:0000603)2.56631232
38Poor coordination (HP:0002370)2.56544087
39Male pseudohermaphroditism (HP:0000037)2.51603580
4011 pairs of ribs (HP:0000878)2.51117989
41Type II lissencephaly (HP:0007260)2.50638501
42Polydipsia (HP:0001959)2.50017883
43Abnormal drinking behavior (HP:0030082)2.50017883
44Abnormality of macular pigmentation (HP:0008002)2.48296002
45Postaxial foot polydactyly (HP:0001830)2.47870725
46Constricted visual fields (HP:0001133)2.46918731
47Vaginal atresia (HP:0000148)2.37635456
48Genital tract atresia (HP:0001827)2.37309680
49Facial cleft (HP:0002006)2.35064421
50B lymphocytopenia (HP:0010976)2.33724662
51Abnormality of B cell number (HP:0010975)2.33724662
52Severe visual impairment (HP:0001141)2.33680237
53Chronic sinusitis (HP:0011109)2.33556672
54Preaxial hand polydactyly (HP:0001177)2.32782028
55Abnormal rod and cone electroretinograms (HP:0008323)2.32701487
56Type I transferrin isoform profile (HP:0003642)2.32015363
57Reticulocytopenia (HP:0001896)2.29167545
58Focal motor seizures (HP:0011153)2.27872111
59Optic disc pallor (HP:0000543)2.23422779
60Epileptic encephalopathy (HP:0200134)2.21644173
61Furrowed tongue (HP:0000221)2.21128505
62Abnormality of the renal medulla (HP:0100957)2.19857111
63Muscle fiber atrophy (HP:0100295)2.17591774
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16443178
65Aplasia/Hypoplasia of the tongue (HP:0010295)2.15743515
66Increased hepatocellular lipid droplets (HP:0006565)2.13572196
67Broad-based gait (HP:0002136)2.13473278
68Bronchitis (HP:0012387)2.13021602
69Hepatic necrosis (HP:0002605)2.10495764
70Birth length less than 3rd percentile (HP:0003561)2.10192549
71Short tibia (HP:0005736)2.09508490
72Congenital hepatic fibrosis (HP:0002612)2.09043238
73Postaxial hand polydactyly (HP:0001162)2.07684658
743-Methylglutaconic aciduria (HP:0003535)2.07231369
75Cystic liver disease (HP:0006706)2.05019492
76Optic nerve hypoplasia (HP:0000609)2.04859014
77Colon cancer (HP:0003003)2.04255290
78Fibular hypoplasia (HP:0003038)1.98693424
79Gaze-evoked nystagmus (HP:0000640)1.98214832
80Absent speech (HP:0001344)1.97902162
81Anencephaly (HP:0002323)1.97603057
82Abnormal biliary tract physiology (HP:0012439)1.96976616
83Bile duct proliferation (HP:0001408)1.96976616
84Decreased central vision (HP:0007663)1.96198930
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.94575104
86Increased serum pyruvate (HP:0003542)1.92239900
87Abnormality of glycolysis (HP:0004366)1.92239900
88Abnormality of the labia minora (HP:0012880)1.92145138
89Abnormal delayed hypersensitivity skin test (HP:0002963)1.92042823
90Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91461552
91Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91461552
92Progressive cerebellar ataxia (HP:0002073)1.90886006
93Supernumerary spleens (HP:0009799)1.90579116
94Exercise intolerance (HP:0003546)1.88372800
95Broad foot (HP:0001769)1.87953176
96Occipital encephalocele (HP:0002085)1.87119539
97Aplasia/Hypoplasia of the lens (HP:0008063)1.86591027
98Tubulointerstitial nephritis (HP:0001970)1.86449388
99Polyuria (HP:0000103)1.86278316
100Bony spicule pigmentary retinopathy (HP:0007737)1.86146130
101Rough bone trabeculation (HP:0100670)1.84546864
102Median cleft lip (HP:0000161)1.84344839
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84304012
104Inability to walk (HP:0002540)1.82577177
105Renal Fanconi syndrome (HP:0001994)1.82296940
106Attenuation of retinal blood vessels (HP:0007843)1.81586480
107Increased intramyocellular lipid droplets (HP:0012240)1.81570166
108Renal cortical cysts (HP:0000803)1.81478517
109Tubulointerstitial abnormality (HP:0001969)1.80379066
110Increased serum lactate (HP:0002151)1.80086221
111Abolished electroretinogram (ERG) (HP:0000550)1.79862336
112Congenital stationary night blindness (HP:0007642)1.79802110
113Cerebellar dysplasia (HP:0007033)1.78411837
114Oligodactyly (hands) (HP:0001180)1.78386052
115Scotoma (HP:0000575)1.78259599
116Narrow forehead (HP:0000341)1.78203957
117Abnormality of the fovea (HP:0000493)1.77771823
118Keratoconus (HP:0000563)1.77497449
119Increased corneal curvature (HP:0100692)1.77497449
120Infertility (HP:0000789)1.75466897
121Hyperventilation (HP:0002883)1.75057390
122Large for gestational age (HP:0001520)1.74209582
123Widely spaced teeth (HP:0000687)1.72575761
124Agammaglobulinemia (HP:0004432)1.72198967
125Recurrent bronchitis (HP:0002837)1.71452896
126Oculomotor apraxia (HP:0000657)1.71343072
127Abnormality of renal resorption (HP:0011038)1.70169466
128Hypothermia (HP:0002045)1.69707661
129Medulloblastoma (HP:0002885)1.69433795
130IgM deficiency (HP:0002850)1.69369477
131Prominent nasal bridge (HP:0000426)1.68658268
132Unsteady gait (HP:0002317)1.68599049
133Aganglionic megacolon (HP:0002251)1.68220967
134Nasal polyposis (HP:0100582)1.67772199
135Pancytopenia (HP:0001876)1.67619175
136Multicystic kidney dysplasia (HP:0000003)1.67344858
137Astigmatism (HP:0000483)1.67250125
138Lissencephaly (HP:0001339)1.65941081
139Febrile seizures (HP:0002373)1.64238556
140Hemiparesis (HP:0001269)1.60260870
141Decreased circulating renin level (HP:0003351)1.58962045
142Stage 5 chronic kidney disease (HP:0003774)1.58077091
143Aplasia/Hypoplasia of the spleen (HP:0010451)1.58064236
144Protruding tongue (HP:0010808)1.57124707
145Septo-optic dysplasia (HP:0100842)1.57105425
146Pachygyria (HP:0001302)1.57079985
147Congenital, generalized hypertrichosis (HP:0004540)1.56570011
148Aplasia/hypoplasia of the uterus (HP:0008684)1.56306384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.00196580
2FRK4.41651457
3PINK13.26725962
4TNIK3.17897811
5MAP4K22.63731687
6PASK2.54303292
7ADRBK22.42376010
8VRK12.41136534
9PDK42.38899629
10PDK32.38899629
11NME12.35422210
12WNK32.30062132
13GRK72.23975496
14CCNB12.18456961
15WEE12.10856356
16CDC72.04105593
17CASK2.01154539
18MAP2K71.99018434
19PDK21.98709727
20EIF2AK31.98598703
21MAP3K61.96107988
22NEK11.80903005
23INSRR1.79265721
24TSSK61.79175087
25MAPK131.74561342
26CDK81.73032512
27MUSK1.71208046
28DYRK31.70150028
29WNK41.64572686
30CDK31.59356073
31STK38L1.56455273
32STK391.52919117
33NTRK31.52118748
34SRPK11.50987397
35TLK11.50944703
36CDK191.39293452
37NUAK11.38832643
38RAF11.33451840
39MINK11.29892858
40OXSR11.27245843
41BMPR21.23603446
42TAOK31.23516230
43ATR1.22852608
44ERBB31.21424978
45PLK41.17953961
46MAP3K121.17472828
47PLK31.13976629
48PAK31.13646929
49TXK1.12912202
50NEK61.09726720
51PTK2B1.05930473
52PLK21.05519650
53TEC1.05491848
54BUB11.03718812
55TRIM281.03335269
56CSNK1G21.01656651
57MKNK21.00800009
58TGFBR11.00638936
59PIM20.99442754
60MARK10.97611288
61CAMKK20.96662918
62FGFR20.95760459
63BCR0.94780624
64MST40.94522791
65CSNK1G10.93569341
66SIK30.91677451
67MAP2K60.90310530
68PRKCE0.87491934
69MAPKAPK50.87466850
70MAPK150.87050734
71DAPK10.86540745
72ARAF0.83859717
73MAP3K40.82766059
74YES10.81401713
75FES0.81264746
76OBSCN0.79522157
77CHEK20.77003465
78PHKG20.75145376
79PHKG10.75145376
80DAPK20.74146881
81PRKCG0.73911966
82BMPR1B0.73684957
83GRK10.73654586
84CSNK1G30.73160516
85NLK0.72936871
86ADRBK10.72701159
87CSNK1A1L0.72420251
88BTK0.71540183
89IRAK40.71433852
90DYRK1A0.70709236
91ACVR1B0.70093929
92KIT0.69085450
93CAMK1G0.68235047
94BRSK10.68106137
95PLK10.67170764
96EPHA30.66972196
97MKNK10.66047586
98CAMK10.65413777
99PIK3CA0.65212537
100CAMK2A0.64967186
101MARK30.64352234
102SYK0.64030196
103BRAF0.62437464
104PNCK0.61827030
105MAPKAPK30.61300800
106EPHB20.61146830
107PKN10.61061651
108RPS6KA50.60619654
109ZAK0.60272250
110SGK4940.60149771
111SGK2230.60149771
112BRSK20.59694401
113EPHA40.59227236
114SGK20.58705086
115AURKB0.58264329
116AURKA0.57409444
117STK30.56278935
118PRKCQ0.54236994
119STK110.52350680
120AKT30.51938421
121EIF2AK20.50714129
122NEK20.50534269
123RPS6KB20.50319130
124ZAP700.50209300
125CDK70.50017127
126LATS10.49887034
127TIE10.48903371
128EEF2K0.48694367
129PRKACA0.48553390
130BCKDK0.48019893
131CSNK2A20.47852688
132CSNK2A10.47799494
133CDK180.47581173
134CDK11A0.46600082
135LYN0.44884816
136MAP4K10.44739517
137UHMK10.44708636
138RPS6KB10.44419417
139DYRK20.42092546
140CSNK1A10.40487820
141TNK20.40451798
142CHEK10.40359949
143NME20.39832267
144CDK150.39799162
145ROCK10.39624281
146GRK50.39479145
147IRAK10.36425082
148ATM0.35491900
149MAP3K50.34774814
150PRKCI0.34483992
151CSNK1D0.34132293
152CDK50.33621481
153MAP2K30.33323591
154NTRK20.33310715
155MAP2K40.33146405
156SGK10.32913461
157PRKG10.32532899
158CAMKK10.31175821

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.43294990
2Ribosome_Homo sapiens_hsa030103.40963001
3Mismatch repair_Homo sapiens_hsa034303.20200682
4Protein export_Homo sapiens_hsa030603.08663788
5Proteasome_Homo sapiens_hsa030502.97723471
6RNA polymerase_Homo sapiens_hsa030202.83211405
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66997070
8Butanoate metabolism_Homo sapiens_hsa006502.61929321
9Base excision repair_Homo sapiens_hsa034102.59363081
10Oxidative phosphorylation_Homo sapiens_hsa001902.37823816
11Spliceosome_Homo sapiens_hsa030402.34590088
12Nucleotide excision repair_Homo sapiens_hsa034202.27081299
13Homologous recombination_Homo sapiens_hsa034402.25823517
14Nitrogen metabolism_Homo sapiens_hsa009102.23286456
15Parkinsons disease_Homo sapiens_hsa050122.09437517
16Huntingtons disease_Homo sapiens_hsa050162.07380009
17Basal transcription factors_Homo sapiens_hsa030222.04058546
18Pyrimidine metabolism_Homo sapiens_hsa002402.02972515
19Nicotine addiction_Homo sapiens_hsa050331.95697073
20Linoleic acid metabolism_Homo sapiens_hsa005911.93483744
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91385884
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86722011
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.82372928
24Fanconi anemia pathway_Homo sapiens_hsa034601.82270243
25Propanoate metabolism_Homo sapiens_hsa006401.78584505
26Non-homologous end-joining_Homo sapiens_hsa034501.77079798
27RNA transport_Homo sapiens_hsa030131.71469899
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64759060
29Purine metabolism_Homo sapiens_hsa002301.63472891
30Alzheimers disease_Homo sapiens_hsa050101.61438777
31beta-Alanine metabolism_Homo sapiens_hsa004101.59092402
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.55009176
33Chemical carcinogenesis_Homo sapiens_hsa052041.54751508
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54625252
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54402119
36Synaptic vesicle cycle_Homo sapiens_hsa047211.47624844
37Tryptophan metabolism_Homo sapiens_hsa003801.47109102
38Hedgehog signaling pathway_Homo sapiens_hsa043401.42684521
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42675110
40Phototransduction_Homo sapiens_hsa047441.39100631
41RNA degradation_Homo sapiens_hsa030181.38395094
42Primary immunodeficiency_Homo sapiens_hsa053401.37353341
43Selenocompound metabolism_Homo sapiens_hsa004501.37048284
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35506237
45Olfactory transduction_Homo sapiens_hsa047401.30000164
46ABC transporters_Homo sapiens_hsa020101.28481563
47Peroxisome_Homo sapiens_hsa041461.25248387
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23637296
49Caffeine metabolism_Homo sapiens_hsa002321.19854001
50Cell cycle_Homo sapiens_hsa041101.19230136
51Collecting duct acid secretion_Homo sapiens_hsa049661.16154540
52Histidine metabolism_Homo sapiens_hsa003401.14406092
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13609639
54mRNA surveillance pathway_Homo sapiens_hsa030151.13446676
55Ether lipid metabolism_Homo sapiens_hsa005651.12944824
56Circadian entrainment_Homo sapiens_hsa047131.11662410
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07353016
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05148278
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03812150
60Basal cell carcinoma_Homo sapiens_hsa052171.03491596
61Retinol metabolism_Homo sapiens_hsa008301.03027950
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.01887672
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01340761
64Morphine addiction_Homo sapiens_hsa050321.00627637
65Insulin secretion_Homo sapiens_hsa049110.98582878
66Amphetamine addiction_Homo sapiens_hsa050310.97130812
67Taste transduction_Homo sapiens_hsa047420.96414998
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94181468
69GABAergic synapse_Homo sapiens_hsa047270.93055614
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91376058
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90281159
72Cardiac muscle contraction_Homo sapiens_hsa042600.87452425
73Oocyte meiosis_Homo sapiens_hsa041140.86434260
74Fatty acid degradation_Homo sapiens_hsa000710.86432710
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.86325376
76Vibrio cholerae infection_Homo sapiens_hsa051100.86157725
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85552158
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84332383
79Long-term potentiation_Homo sapiens_hsa047200.83281092
80Glutamatergic synapse_Homo sapiens_hsa047240.82838631
81N-Glycan biosynthesis_Homo sapiens_hsa005100.82453323
82Serotonergic synapse_Homo sapiens_hsa047260.79466627
83Calcium signaling pathway_Homo sapiens_hsa040200.76896096
84Steroid biosynthesis_Homo sapiens_hsa001000.75630764
85Dopaminergic synapse_Homo sapiens_hsa047280.74470056
86Dorso-ventral axis formation_Homo sapiens_hsa043200.73919658
87Epstein-Barr virus infection_Homo sapiens_hsa051690.73304121
88Alcoholism_Homo sapiens_hsa050340.69578833
89Ovarian steroidogenesis_Homo sapiens_hsa049130.69285323
90Antigen processing and presentation_Homo sapiens_hsa046120.68434780
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67917787
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62388501
93Glycerolipid metabolism_Homo sapiens_hsa005610.59383341
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56671729
95Tyrosine metabolism_Homo sapiens_hsa003500.56623416
96Hippo signaling pathway_Homo sapiens_hsa043900.55527242
97Axon guidance_Homo sapiens_hsa043600.51545919
98Glutathione metabolism_Homo sapiens_hsa004800.51498577
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47644486
100Salivary secretion_Homo sapiens_hsa049700.46598597
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45184711
102Cholinergic synapse_Homo sapiens_hsa047250.43995696
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43780137
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43718891
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42235188
106Renin secretion_Homo sapiens_hsa049240.41812213
107Arachidonic acid metabolism_Homo sapiens_hsa005900.39133984
108Circadian rhythm_Homo sapiens_hsa047100.38524605
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37837358
110Wnt signaling pathway_Homo sapiens_hsa043100.37790853
111TGF-beta signaling pathway_Homo sapiens_hsa043500.37761332
112Oxytocin signaling pathway_Homo sapiens_hsa049210.37698483
113p53 signaling pathway_Homo sapiens_hsa041150.36685206
114Mineral absorption_Homo sapiens_hsa049780.36014842
115T cell receptor signaling pathway_Homo sapiens_hsa046600.35871744
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35661104
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35489146
118Fatty acid metabolism_Homo sapiens_hsa012120.34575795
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33437496
120Gastric acid secretion_Homo sapiens_hsa049710.32467630
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30646502
122Metabolic pathways_Homo sapiens_hsa011000.30369009
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30002241
124Systemic lupus erythematosus_Homo sapiens_hsa053220.29679859
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29076866
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28988827
127Regulation of autophagy_Homo sapiens_hsa041400.28943942
128Long-term depression_Homo sapiens_hsa047300.27900142
129Pentose phosphate pathway_Homo sapiens_hsa000300.26495507
130Thyroid hormone synthesis_Homo sapiens_hsa049180.26050788
131Hematopoietic cell lineage_Homo sapiens_hsa046400.25334136
132Fructose and mannose metabolism_Homo sapiens_hsa000510.25019900
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.25013562
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24974596
135Herpes simplex infection_Homo sapiens_hsa051680.23482670
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22883580
137Cocaine addiction_Homo sapiens_hsa050300.22501586
138Glucagon signaling pathway_Homo sapiens_hsa049220.21182942
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20308893
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19815050
141HTLV-I infection_Homo sapiens_hsa051660.19109226
142Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.17526806
143cAMP signaling pathway_Homo sapiens_hsa040240.17343811
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17169511

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