CLU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.20961371
2synaptic vesicle maturation (GO:0016188)5.17908824
3low-density lipoprotein particle remodeling (GO:0034374)4.64524564
4glutamate secretion (GO:0014047)4.61520848
5alpha-linolenic acid metabolic process (GO:0036109)4.32601499
6postsynaptic membrane organization (GO:0001941)4.28923309
7regulation of synaptic vesicle exocytosis (GO:2000300)4.10454278
8synaptic vesicle exocytosis (GO:0016079)4.06636491
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.03127713
10potassium ion homeostasis (GO:0055075)3.99416235
11cellular response to cholesterol (GO:0071397)3.90095381
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.86707988
13regulation of short-term neuronal synaptic plasticity (GO:0048172)3.79132909
14astrocyte differentiation (GO:0048708)3.74539170
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.72496742
16axon ensheathment in central nervous system (GO:0032291)3.71999084
17central nervous system myelination (GO:0022010)3.71999084
18L-serine transport (GO:0015825)3.70230786
19neuronal action potential propagation (GO:0019227)3.67369452
20cellular modified amino acid catabolic process (GO:0042219)3.65037222
21neurotransmitter secretion (GO:0007269)3.64856970
22alanine transport (GO:0032328)3.63498062
23neurotransmitter uptake (GO:0001504)3.57505802
24cerebellar granule cell differentiation (GO:0021707)3.57421829
25sulfur amino acid catabolic process (GO:0000098)3.54972001
26regulation of neuronal synaptic plasticity (GO:0048168)3.51039850
27C4-dicarboxylate transport (GO:0015740)3.49924402
28positive regulation of triglyceride biosynthetic process (GO:0010867)3.49836157
29regulation of synaptic vesicle transport (GO:1902803)3.46133624
30ovulation cycle (GO:0042698)3.43193574
31negative regulation of astrocyte differentiation (GO:0048712)3.39494072
32cellular potassium ion homeostasis (GO:0030007)3.36189010
33cellular response to sterol (GO:0036315)3.35872305
34sterol catabolic process (GO:0016127)3.34970663
35cholesterol catabolic process (GO:0006707)3.34970663
36cell communication by electrical coupling (GO:0010644)3.34917503
37regulation of cholesterol esterification (GO:0010872)3.34679464
38protein-lipid complex remodeling (GO:0034368)3.31694854
39macromolecular complex remodeling (GO:0034367)3.31694854
40plasma lipoprotein particle remodeling (GO:0034369)3.31694854
41regulation of cholesterol biosynthetic process (GO:0045540)3.26996338
42sodium ion export (GO:0071436)3.26376320
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.24047478
44vocalization behavior (GO:0071625)3.23748705
45astrocyte development (GO:0014002)3.22892558
46presynaptic membrane assembly (GO:0097105)3.21948074
47L-serine metabolic process (GO:0006563)3.20637583
48high-density lipoprotein particle remodeling (GO:0034375)3.20190676
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.20058221
50* reverse cholesterol transport (GO:0043691)3.19241769
51peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.18282645
52presynaptic membrane organization (GO:0097090)3.16629164
53cerebellar Purkinje cell layer development (GO:0021680)3.16177608
54response to auditory stimulus (GO:0010996)3.15969573
55neuronal ion channel clustering (GO:0045161)3.15265850
56regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14952307
57serine transport (GO:0032329)3.13909765
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.12413149
59neuron cell-cell adhesion (GO:0007158)3.09919526
60lung epithelium development (GO:0060428)3.08960106
61cysteine metabolic process (GO:0006534)3.08486760
62chondroitin sulfate catabolic process (GO:0030207)3.08452230
63negative regulation of sodium ion transport (GO:0010766)3.08381184
64linoleic acid metabolic process (GO:0043651)3.08358786
65ionotropic glutamate receptor signaling pathway (GO:0035235)3.05473080
66regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.03104980
67neurotransmitter transport (GO:0006836)3.02224636
68dicarboxylic acid biosynthetic process (GO:0043650)3.00724651
69neurotransmitter-gated ion channel clustering (GO:0072578)3.00458571
70exploration behavior (GO:0035640)2.98399213
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.97219458
72L-phenylalanine catabolic process (GO:0006559)2.97219458
73glutamate metabolic process (GO:0006536)2.93332008
74very long-chain fatty acid metabolic process (GO:0000038)2.92813931
75regulation of neurotransmitter levels (GO:0001505)2.92182689
76regulation of triglyceride biosynthetic process (GO:0010866)2.90447546
77gap junction assembly (GO:0016264)2.89165357
78amino acid import (GO:0043090)2.85806312
79plasma lipoprotein particle organization (GO:0071827)2.84890539
80keratan sulfate catabolic process (GO:0042340)2.84285195
81negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83840967
82regulation of neurotransmitter uptake (GO:0051580)2.83541792
83positive regulation of synapse maturation (GO:0090129)2.83090418
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.82807492
85erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.81816079
86L-phenylalanine metabolic process (GO:0006558)2.81816079
87response to leptin (GO:0044321)2.79936157
88L-amino acid import (GO:0043092)2.79411150
89response to nitrosative stress (GO:0051409)2.78487599
90positive regulation of triglyceride metabolic process (GO:0090208)2.75664684
91purine nucleotide transport (GO:0015865)2.75624090
92aspartate family amino acid catabolic process (GO:0009068)2.75008342
93dicarboxylic acid catabolic process (GO:0043649)2.74533546
94adenine nucleotide transport (GO:0051503)2.74243121
95regulation of glutamate receptor signaling pathway (GO:1900449)2.74166247
96regulation of synapse structural plasticity (GO:0051823)2.73631012
97very-low-density lipoprotein particle assembly (GO:0034379)2.73567841
98cellular sodium ion homeostasis (GO:0006883)2.73119932
99gonadal mesoderm development (GO:0007506)2.73023635
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.72927238
101plasma lipoprotein particle assembly (GO:0034377)2.72654576
102acidic amino acid transport (GO:0015800)2.72523874
103regulation of hydrogen peroxide-induced cell death (GO:1903205)2.71942909
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71265247
105ethanol oxidation (GO:0006069)2.71209770
106regulation of neurotransmitter transport (GO:0051588)2.69255881
107synaptic transmission, glutamatergic (GO:0035249)2.68683209
108neuromuscular process controlling posture (GO:0050884)2.68130201
109long-term synaptic potentiation (GO:0060291)2.67600753
110amino-acid betaine metabolic process (GO:0006577)2.67231777
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65455610
112response to dietary excess (GO:0002021)2.64752397
113regulation of synaptic plasticity (GO:0048167)2.64505343
114protein-lipid complex subunit organization (GO:0071825)2.62297120
115synaptic vesicle endocytosis (GO:0048488)2.62072310
116dendritic spine morphogenesis (GO:0060997)2.61975866
117purine ribonucleotide transport (GO:0015868)2.61655711
118regulation of neurotransmitter secretion (GO:0046928)2.61501326
119locomotory exploration behavior (GO:0035641)2.60147478
120* glial cell proliferation (GO:0014009)2.59949169
121phospholipid efflux (GO:0033700)2.59197872
122positive regulation of membrane potential (GO:0045838)2.57989008
123regulation of cholesterol homeostasis (GO:2000188)2.57683914
124regulation of glomerular filtration (GO:0003093)2.57661420
125regulation of voltage-gated calcium channel activity (GO:1901385)2.56985833
126regulation of cholesterol metabolic process (GO:0090181)2.56474763
127neuromuscular process controlling balance (GO:0050885)2.55431172
128response to gravity (GO:0009629)2.54487941
129homocysteine metabolic process (GO:0050667)2.53773605
130aromatic amino acid family catabolic process (GO:0009074)2.53237843
131carnitine metabolic process (GO:0009437)2.53222327
132positive regulation of neurotransmitter transport (GO:0051590)2.52481478
133detection of calcium ion (GO:0005513)2.52283622
134bile acid biosynthetic process (GO:0006699)2.51828150
135cellular amino acid catabolic process (GO:0009063)2.50765590
136alpha-amino acid catabolic process (GO:1901606)2.50659959
137one-carbon compound transport (GO:0019755)2.49677022
138fructose metabolic process (GO:0006000)2.48090640
139sodium ion homeostasis (GO:0055078)2.47843057
140layer formation in cerebral cortex (GO:0021819)2.47600987
141positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.46829456
142protein localization to synapse (GO:0035418)2.45974335
143cellular response to leptin stimulus (GO:0044320)2.45841035
144lysine metabolic process (GO:0006553)2.45655323
145lysine catabolic process (GO:0006554)2.45655323
146negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.45594859
147negative regulation of response to reactive oxygen species (GO:1901032)2.45018140
148cell communication involved in cardiac conduction (GO:0086065)2.44751168
149potassium ion import (GO:0010107)2.44633468
150regulation of astrocyte differentiation (GO:0048710)2.44238337
151positive regulation of sodium ion transmembrane transport (GO:1902307)2.43164623
152L-glutamate transport (GO:0015813)2.42980003
153regulation of ARF protein signal transduction (GO:0032012)2.42364245
154kynurenine metabolic process (GO:0070189)2.42127175
155neuron projection regeneration (GO:0031102)2.41767638
156macroautophagy (GO:0016236)2.41207510
157positive regulation of neurotransmitter secretion (GO:0001956)2.40949829
158auditory behavior (GO:0031223)2.40555455
159regulation of respiratory system process (GO:0044065)2.39837484
160negative regulation of complement activation (GO:0045916)2.39258368
161eye photoreceptor cell differentiation (GO:0001754)2.39146026
162photoreceptor cell differentiation (GO:0046530)2.39146026
163regulation of female receptivity (GO:0045924)2.38654199
164cytoskeletal anchoring at plasma membrane (GO:0007016)2.38447906
165positive regulation of dendritic spine development (GO:0060999)2.38178109
166positive regulation of male gonad development (GO:2000020)2.37761856
167neurotransmitter catabolic process (GO:0042135)2.37009329
168membrane repolarization (GO:0086009)2.35952724
169protein-lipid complex assembly (GO:0065005)2.35103238
170regulation of apoptotic cell clearance (GO:2000425)2.34451927
171gamma-aminobutyric acid transport (GO:0015812)2.34348583
172glutamate receptor signaling pathway (GO:0007215)2.34336421
173regulation of complement activation (GO:0030449)2.34099458
174sex differentiation (GO:0007548)2.33847417
175lens fiber cell development (GO:0070307)2.33594151
176valine metabolic process (GO:0006573)2.33530682
177serine family amino acid biosynthetic process (GO:0009070)2.33420066
178regulation of cardiac muscle cell contraction (GO:0086004)2.32931991
179artery smooth muscle contraction (GO:0014824)2.32929283
180positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.32501181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.32244754
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.01865682
3LXR_22158963_ChIP-Seq_LIVER_Mouse2.67260444
4FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.63844944
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57607273
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.22211863
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03937812
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96813167
9ESR2_21235772_ChIP-Seq_MCF-7_Human1.91946088
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91337980
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89623239
12IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88540524
13* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84358536
14MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83541171
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.79953902
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79673622
17AR_21572438_ChIP-Seq_LNCaP_Human1.78661502
18* CLOCK_20551151_ChIP-Seq_293T_Human1.76398325
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.76011350
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73531995
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71328014
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70801493
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67552550
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66899777
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.66837428
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64841436
27* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62620110
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.61268081
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58018088
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56400918
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55927041
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55927041
33* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48587306
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.48491639
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47336058
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45549622
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.41193036
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38565961
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37978282
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37110700
41DROSHA_22980978_ChIP-Seq_HELA_Human1.33481954
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33232746
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32705220
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.29779289
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24839163
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24839163
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.23015647
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22836911
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.21560163
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21080902
51* FOXA2_19822575_ChIP-Seq_HepG2_Human1.20324546
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19580125
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19561852
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19559401
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19390089
56* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16667157
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.13843074
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12670531
59PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12585322
60BCAT_22108803_ChIP-Seq_LS180_Human1.11645199
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08877884
62TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08560316
63EZH2_22144423_ChIP-Seq_EOC_Human1.08202113
64GBX2_23144817_ChIP-Seq_PC3_Human1.07963318
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07721168
66* LXR_22292898_ChIP-Seq_THP-1_Human1.07584486
67TET1_21490601_ChIP-Seq_MESCs_Mouse1.05912647
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05061317
69* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01895759
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00296245
71RING1B_27294783_Chip-Seq_ESCs_Mouse0.99509778
72EZH2_27304074_Chip-Seq_ESCs_Mouse0.98959141
73OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98344254
74REST_21632747_ChIP-Seq_MESCs_Mouse0.97767889
75DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97531911
76SMC4_20622854_ChIP-Seq_HELA_Human0.97370497
77TP53_20018659_ChIP-ChIP_R1E_Mouse0.96864862
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96504413
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95302431
80STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94718539
81CTCF_27219007_Chip-Seq_Bcells_Human0.94663995
82NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94120342
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93220897
84FOXO3_23340844_ChIP-Seq_DLD1_Human0.92453406
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.92419942
86SOX2_20726797_ChIP-Seq_SW620_Human0.91967704
87WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91872344
88RARB_27405468_Chip-Seq_BRAIN_Mouse0.90536771
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90390268
90PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89647190
91SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89393312
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.89346741
93SMAD4_21799915_ChIP-Seq_A2780_Human0.89317626
94TP53_18474530_ChIP-ChIP_U2OS_Human0.89215994
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88476428
96AHR_22903824_ChIP-Seq_MCF-7_Human0.88406842
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87832838
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86998974
99RXR_22108803_ChIP-Seq_LS180_Human0.86919319
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86826458
101* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86323579
102CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85792426
103* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83717713
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83408733
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83140787
106NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82782579
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82633120
108SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82509917
109TP53_16413492_ChIP-PET_HCT116_Human0.82395461
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81946650
111SOX2_21211035_ChIP-Seq_LN229_Gbm0.81923163
112REST_18959480_ChIP-ChIP_MESCs_Mouse0.81420735
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.81123352
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.81056363
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.80216323
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79864275
117RUNX1_27514584_Chip-Seq_MCF-7_Human0.79397976
118AR_25329375_ChIP-Seq_VCAP_Human0.79368170
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79176390
120AR_19668381_ChIP-Seq_PC3_Human0.79109753
121PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.79062037
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78521495
123* CJUN_26792858_Chip-Seq_BT549_Human0.78248253
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.76696857
125KDM2B_26808549_Chip-Seq_K562_Human0.76327837
126KLF5_25053715_ChIP-Seq_YYC3_Human0.75975998
127* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75757053
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75600384
129NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75426433
130KLF4_19829295_ChIP-Seq_ESCs_Human0.75386560
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.75216666
132ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73199501
133MYC_19915707_ChIP-ChIP_AK7_Human0.73053276
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.69963388
135TP53_23651856_ChIP-Seq_MEFs_Mouse0.68938428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.31960052
2MP0004858_abnormal_nervous_system3.59514644
3MP0002254_reproductive_system_inflammat3.55393763
4MP0003880_abnormal_central_pattern3.49522248
5MP0003690_abnormal_glial_cell3.26135803
6MP0005423_abnormal_somatic_nervous3.15895175
7MP0003011_delayed_dark_adaptation2.87667860
8MP0005365_abnormal_bile_salt2.85594448
9MP0005360_urolithiasis2.78579242
10MP0005377_hearing/vestibular/ear_phenot2.78022515
11MP0003878_abnormal_ear_physiology2.78022515
12MP0009384_cardiac_valve_regurgitation2.72821211
13MP0009780_abnormal_chondrocyte_physiolo2.69440917
14MP0009840_abnormal_foam_cell2.64019279
15MP0005085_abnormal_gallbladder_physiolo2.62648652
16MP0003195_calcinosis2.47329203
17MP0002272_abnormal_nervous_system2.31004413
18MP0010329_abnormal_lipoprotein_level2.27929484
19MP0005332_abnormal_amino_acid2.25154972
20MP0002734_abnormal_mechanical_nocicepti2.24643754
21MP0005646_abnormal_pituitary_gland2.19097459
22MP0005503_abnormal_tendon_morphology2.16605875
23MP0001968_abnormal_touch/_nociception2.10830308
24MP0001501_abnormal_sleep_pattern1.99930107
25MP0008875_abnormal_xenobiotic_pharmacok1.96628230
26* MP0003329_amyloid_beta_deposits1.94357420
27MP0001970_abnormal_pain_threshold1.89676043
28MP0004885_abnormal_endolymph1.88848398
29MP0004859_abnormal_synaptic_plasticity1.88121524
30MP0000920_abnormal_myelination1.86063214
31MP0010234_abnormal_vibrissa_follicle1.85976668
32MP0005167_abnormal_blood-brain_barrier1.83774341
33MP0003252_abnormal_bile_duct1.76902572
34MP0002736_abnormal_nociception_after1.74339574
35MP0001666_abnormal_nutrient_absorption1.73253232
36MP0005647_abnormal_sex_gland1.70767766
37MP0004019_abnormal_vitamin_homeostasis1.67105752
38MP0002735_abnormal_chemical_nociception1.66369620
39MP0003075_altered_response_to1.64133151
40MP0005083_abnormal_biliary_tract1.61658471
41MP0002090_abnormal_vision1.57240740
42MP0001905_abnormal_dopamine_level1.54256594
43MP0001440_abnormal_grooming_behavior1.52328072
44MP0002909_abnormal_adrenal_gland1.46217544
45MP0010386_abnormal_urinary_bladder1.45920007
46MP0000566_synostosis1.35144381
47MP0003300_gastrointestinal_ulcer1.33931033
48MP0003279_aneurysm1.32369287
49MP0001502_abnormal_circadian_rhythm1.29613131
50MP0003122_maternal_imprinting1.26066555
51MP0006276_abnormal_autonomic_nervous1.26024388
52MP0002067_abnormal_sensory_capabilities1.25941537
53MP0003806_abnormal_nucleotide_metabolis1.23090119
54MP0002118_abnormal_lipid_homeostasis1.20787625
55MP0003634_abnormal_glial_cell1.20249492
56MP0002876_abnormal_thyroid_physiology1.18610939
57* MP0000604_amyloidosis1.16291677
58MP0000778_abnormal_nervous_system1.15954701
59MP0002066_abnormal_motor_capabilities/c1.15543245
60MP0002138_abnormal_hepatobiliary_system1.15002289
61MP0005058_abnormal_lysosome_morphology1.14723940
62MP0004811_abnormal_neuron_physiology1.13951540
63MP0001984_abnormal_olfaction1.12522234
64MP0001958_emphysema1.10982488
65MP0001756_abnormal_urination1.10568970
66MP0005165_increased_susceptibility_to1.10500344
67MP0003635_abnormal_synaptic_transmissio1.10120873
68* MP0003632_abnormal_nervous_system1.09885212
69MP0002168_other_aberrant_phenotype1.08743110
70MP0008995_early_reproductive_senescence1.08552158
71MP0003633_abnormal_nervous_system1.08434977
72MP0004272_abnormal_basement_membrane1.06950709
73MP0003879_abnormal_hair_cell1.06922240
74MP0001486_abnormal_startle_reflex1.06323108
75MP0002653_abnormal_ependyma_morphology1.06322006
76MP0002229_neurodegeneration1.05511172
77* MP0002882_abnormal_neuron_morphology1.04938750
78MP0002295_abnormal_pulmonary_circulatio1.03393085
79MP0001881_abnormal_mammary_gland0.99622576
80MP0005166_decreased_susceptibility_to0.99422923
81MP0000955_abnormal_spinal_cord0.98265581
82MP0001664_abnormal_digestion0.96721402
83MP0001963_abnormal_hearing_physiology0.96292739
84MP0003172_abnormal_lysosome_physiology0.95562004
85MP0003045_fibrosis0.94746582
86* MP0003631_nervous_system_phenotype0.94019993
87MP0005275_abnormal_skin_tensile0.93080165
88MP0003868_abnormal_feces_composition0.93063579
89MP0005584_abnormal_enzyme/coenzyme_acti0.93016954
90MP0002572_abnormal_emotion/affect_behav0.92739325
91MP0002063_abnormal_learning/memory/cond0.92690888
92MP0005645_abnormal_hypothalamus_physiol0.92427046
93MP0005551_abnormal_eye_electrophysiolog0.92425030
94MP0002064_seizures0.92027585
95MP0002638_abnormal_pupillary_reflex0.91673347
96MP0009745_abnormal_behavioral_response0.90930178
97MP0000609_abnormal_liver_physiology0.90856656
98MP0000751_myopathy0.89688094
99MP0003186_abnormal_redox_activity0.89584550
100MP0003705_abnormal_hypodermis_morpholog0.88801831
101MP0002928_abnormal_bile_duct0.88566253
102MP0005386_behavior/neurological_phenoty0.87313648
103MP0004924_abnormal_behavior0.87313648
104MP0005595_abnormal_vascular_smooth0.87161592
105MP0005535_abnormal_body_temperature0.86305480
106MP0003115_abnormal_respiratory_system0.85760933
107MP0008874_decreased_physiological_sensi0.84958246
108MP0001661_extended_life_span0.84386448
109MP0005670_abnormal_white_adipose0.82422392
110MP0002557_abnormal_social/conspecific_i0.81180687
111MP0000537_abnormal_urethra_morphology0.81073593
112MP0003638_abnormal_response/metabolism_0.80224917
113MP0009643_abnormal_urine_homeostasis0.80076865
114MP0005623_abnormal_meninges_morphology0.79741089
115MP0002152_abnormal_brain_morphology0.79090229
116MP0005379_endocrine/exocrine_gland_phen0.77903837
117MP0005084_abnormal_gallbladder_morpholo0.77875611
118MP0003787_abnormal_imprinting0.76123859
119MP0005319_abnormal_enzyme/_coenzyme0.75919265
120MP0003136_yellow_coat_color0.74590761
121MP0005253_abnormal_eye_physiology0.71938563
122MP0005248_abnormal_Harderian_gland0.71688728
123MP0003137_abnormal_impulse_conducting0.70881474
124MP0001485_abnormal_pinna_reflex0.70576334
125MP0008872_abnormal_physiological_respon0.70435727
126MP0003183_abnormal_peptide_metabolism0.69954619
127MP0004270_analgesia0.69790944
128MP0002069_abnormal_eating/drinking_beha0.69762170
129MP0002184_abnormal_innervation0.69427024
130MP0000579_abnormal_nail_morphology0.68891715
131MP0005410_abnormal_fertilization0.66730668
132MP0009764_decreased_sensitivity_to0.65586982
133MP0010368_abnormal_lymphatic_system0.65378588
134MP0000639_abnormal_adrenal_gland0.63022907
135MP0000747_muscle_weakness0.62537443
136MP0004130_abnormal_muscle_cell0.62234815
137MP0000013_abnormal_adipose_tissue0.61858607
138MP0002733_abnormal_thermal_nociception0.61787476
139MP0004043_abnormal_pH_regulation0.61731607
140MP0002127_abnormal_cardiovascular_syste0.61720525
141MP0003942_abnormal_urinary_system0.61677333
142MP0008569_lethality_at_weaning0.61422718
143MP0003283_abnormal_digestive_organ0.61158877
144MP0004883_abnormal_blood_vessel0.60000614
145MP0009046_muscle_twitch0.59772677
146MP0001177_atelectasis0.58531849
147MP0000026_abnormal_inner_ear0.56498951
148MP0002108_abnormal_muscle_morphology0.54713055
149MP0001944_abnormal_pancreas_morphology0.54611625

Predicted human phenotypes

RankGene SetZ-score
1Megalencephaly (HP:0001355)5.13377177
2Aplasia involving bones of the upper limbs (HP:0009823)5.10837993
3Aplasia of the phalanges of the hand (HP:0009802)5.10837993
4Aplasia involving bones of the extremities (HP:0009825)5.10837993
5Action tremor (HP:0002345)4.73676141
6Neurofibrillary tangles (HP:0002185)4.53500671
7Systemic lupus erythematosus (HP:0002725)4.10178412
8Onycholysis (HP:0001806)4.03265897
9Focal motor seizures (HP:0011153)3.78605139
10Back pain (HP:0003418)3.73520778
11Cerebral inclusion bodies (HP:0100314)3.71900667
12Xanthomatosis (HP:0000991)3.44950999
13Hyperglycinuria (HP:0003108)3.41260998
14Focal seizures (HP:0007359)3.39568335
15Abnormal eating behavior (HP:0100738)3.34326184
16Obstructive sleep apnea (HP:0002870)3.30473811
17Clumsiness (HP:0002312)3.30373300
18Torticollis (HP:0000473)3.28290976
19Intrahepatic cholestasis (HP:0001406)3.23774199
20Hypoplastic left heart (HP:0004383)3.17607720
21Abnormality of complement system (HP:0005339)3.16380809
22Hypoalphalipoproteinemia (HP:0003233)3.15648755
23Glomerulonephritis (HP:0000099)3.11899778
24Hypoplasia of the uterus (HP:0000013)3.11150569
25Ankle clonus (HP:0011448)3.10646334
26Abnormality of glycine metabolism (HP:0010895)3.10021562
27Abnormality of serine family amino acid metabolism (HP:0010894)3.10021562
28Atonic seizures (HP:0010819)3.07440180
29Deep venous thrombosis (HP:0002625)3.05799200
30Generalized tonic-clonic seizures (HP:0002069)2.99001198
31Hyperlipoproteinemia (HP:0010980)2.97841238
32Gout (HP:0001997)2.96065745
33Hydroxyprolinuria (HP:0003080)2.95883761
34Abnormality of proline metabolism (HP:0010907)2.95883761
35Febrile seizures (HP:0002373)2.91638509
36Intention tremor (HP:0002080)2.87134441
37Focal dystonia (HP:0004373)2.86020875
38Epileptic encephalopathy (HP:0200134)2.84777026
39Aplasia/hypoplasia of the uterus (HP:0008684)2.81054467
40Synostosis involving the elbow (HP:0003938)2.79116661
41Humeroradial synostosis (HP:0003041)2.79116661
42Mitral stenosis (HP:0001718)2.75242313
43Ketosis (HP:0001946)2.74484155
44Papilledema (HP:0001085)2.73852922
45Craniofacial dystonia (HP:0012179)2.72900812
46Ketoacidosis (HP:0001993)2.72642703
47Tetraplegia (HP:0002445)2.72070178
48Hemiplegia (HP:0002301)2.70892811
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.70214155
50Sensorimotor neuropathy (HP:0007141)2.70056661
51Anxiety (HP:0000739)2.62946851
52Postural tremor (HP:0002174)2.62829085
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.61335190
54Mutism (HP:0002300)2.60510373
55Hyperglycinemia (HP:0002154)2.60506887
56Abnormality of the axillary hair (HP:0100134)2.55860226
57Abnormality of secondary sexual hair (HP:0009888)2.55860226
58Nuclear cataract (HP:0100018)2.52587874
59Late onset (HP:0003584)2.51423529
60Hyperammonemia (HP:0001987)2.47953431
61Hypolipoproteinemia (HP:0010981)2.45886084
62Increased circulating renin level (HP:0000848)2.45358454
63Truncal ataxia (HP:0002078)2.45179503
64Male infertility (HP:0003251)2.43924639
65Sleep apnea (HP:0010535)2.43692201
66Increased CSF protein (HP:0002922)2.43131699
67Hemiparesis (HP:0001269)2.41876904
68Tetraparesis (HP:0002273)2.41839125
69Amyloidosis (HP:0011034)2.41354564
70Polyphagia (HP:0002591)2.40456370
71Bronchomalacia (HP:0002780)2.39837409
72Vascular calcification (HP:0004934)2.35958164
73Mesangial abnormality (HP:0001966)2.35187790
74Abnormality of monocarboxylic acid metabolism (HP:0010996)2.33348453
75Gonadal dysgenesis (HP:0000133)2.31275641
76Spastic gait (HP:0002064)2.31190700
77Depression (HP:0000716)2.25579526
78Status epilepticus (HP:0002133)2.25564031
79Absence seizures (HP:0002121)2.24946702
80Progressive cerebellar ataxia (HP:0002073)2.23997264
81Esophageal varix (HP:0002040)2.22193600
82Dysmetria (HP:0001310)2.18256719
83Hypoplastic heart (HP:0001961)2.18221751
84Rigidity (HP:0002063)2.18009213
85Abnormality of the dental pulp (HP:0006479)2.16954513
86Postural instability (HP:0002172)2.15103794
87Right ventricular cardiomyopathy (HP:0011663)2.14882407
88Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.14268834
89Abnormality of sulfur amino acid metabolism (HP:0004339)2.14177836
90Insomnia (HP:0100785)2.09832294
91Cardiovascular calcification (HP:0011915)2.09223724
92Arterial tortuosity (HP:0005116)2.08003328
93Akinesia (HP:0002304)2.07339657
94Pseudobulbar signs (HP:0002200)2.06929356
95Limb dystonia (HP:0002451)2.05143231
96Hypoglycemic coma (HP:0001325)2.05033990
97Peripheral hypomyelination (HP:0007182)2.04452722
98Fragile nails (HP:0001808)2.03721341
99Dysdiadochokinesis (HP:0002075)2.03631638
100Absent hair (HP:0002298)2.03599655
101Delusions (HP:0000746)2.03523187
102Neuronal loss in central nervous system (HP:0002529)2.02632412
103Nephritis (HP:0000123)2.01856758
104Short hallux (HP:0010109)2.01792244
105Dialeptic seizures (HP:0011146)2.01457178
106Abnormality of the dental root (HP:0006486)2.01303339
107Taurodontia (HP:0000679)2.01303339
108Abnormality of permanent molar morphology (HP:0011071)2.01303339
109Purpura (HP:0000979)2.01063291
110Exercise-induced myalgia (HP:0003738)1.98501360
111Prolonged partial thromboplastin time (HP:0003645)1.98179834
112Potter facies (HP:0002009)1.98010835
113Facial shape deformation (HP:0011334)1.98010835
114Tubulointerstitial nephritis (HP:0001970)1.96880244
115Hypercortisolism (HP:0001578)1.96143521
116Scotoma (HP:0000575)1.95101383
117Turricephaly (HP:0000262)1.94740007
118Hyperthyroidism (HP:0000836)1.94540311
119Split foot (HP:0001839)1.94233841
120Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93811444
121Bradykinesia (HP:0002067)1.93299600
122Supranuclear gaze palsy (HP:0000605)1.93185196
123Complement deficiency (HP:0004431)1.93131251
124Diplopia (HP:0000651)1.92388118
125Abnormality of binocular vision (HP:0011514)1.92388118
126Abnormality of molar morphology (HP:0011070)1.91111606
127Abnormality of molar (HP:0011077)1.91111606
128Double outlet right ventricle (HP:0001719)1.90768297
129Congenital malformation of the right heart (HP:0011723)1.90768297
130Fibular aplasia (HP:0002990)1.90359646
131Mild short stature (HP:0003502)1.90248627
132Epileptiform EEG discharges (HP:0011182)1.89596311
133Aplasia/Hypoplasia of the hallux (HP:0008362)1.88849720
134Hypercholesterolemia (HP:0003124)1.87446339
135Cerebral hypomyelination (HP:0006808)1.86964901
136Increased purine levels (HP:0004368)1.84254618
137Hyperuricemia (HP:0002149)1.84254618
138Vascular tortuosity (HP:0004948)1.83857508
139Hypobetalipoproteinemia (HP:0003563)1.82786987
140Annular pancreas (HP:0001734)1.82374314
141Stroke (HP:0001297)1.82120643
142Global brain atrophy (HP:0002283)1.80855009
143Scanning speech (HP:0002168)1.80528550
144Neonatal short-limb short stature (HP:0008921)1.79852531
145Joint hemorrhage (HP:0005261)1.77992717
146Growth hormone excess (HP:0000845)1.77865020
147Abnormality of purine metabolism (HP:0004352)1.77479260
148Hyperventilation (HP:0002883)1.76219631
149Fat malabsorption (HP:0002630)1.75733673
150Delayed CNS myelination (HP:0002188)1.75583848
151Mixed hearing impairment (HP:0000410)1.75353704
152Gonadotropin excess (HP:0000837)1.74961145
153Myokymia (HP:0002411)1.74114331
154Dementia (HP:0000726)1.73167255
155Visual hallucinations (HP:0002367)1.72831320
156Hypoplasia of dental enamel (HP:0006297)1.72741996
157EEG with generalized epileptiform discharges (HP:0011198)1.72686690
158Retinal atrophy (HP:0001105)1.72407707
159Atrioventricular block (HP:0001678)1.71721594
160Abnormality of the diencephalon (HP:0010662)1.71694326
161Abnormality of the middle phalanges of the toes (HP:0010183)1.70585044
162Adactyly (HP:0009776)1.68530560
163Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.68239782
164Sex reversal (HP:0012245)1.67398549
165Abnormal sex determination (HP:0012244)1.67398549
166Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65204459
167Apathy (HP:0000741)1.63552826
168Heart block (HP:0012722)1.60491366
169Truncus arteriosus (HP:0001660)1.60342769
170Spastic tetraparesis (HP:0001285)1.59428367
171Adrenal overactivity (HP:0002717)1.58891233
172Choreoathetosis (HP:0001266)1.58112816
173Hypsarrhythmia (HP:0002521)1.57297773
174Menorrhagia (HP:0000132)1.57092763
175Abnormality of the corticospinal tract (HP:0002492)1.57071822
176J-shaped sella turcica (HP:0002680)1.54521271
177Shallow orbits (HP:0000586)1.54433778
178Spinal cord compression (HP:0002176)1.53602412
179Hammertoe (HP:0001765)1.53164863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.09029599
2EPHA24.47628494
3EPHA43.40979884
4MARK13.14086900
5PHKG23.07156428
6PHKG13.07156428
7PAK62.95734561
8PRKD32.95607220
9SIK12.80971411
10TRIB32.68791528
11NTRK22.48388967
12UHMK12.33833681
13BCKDK1.99451711
14PTK61.84125339
15RIPK11.79373104
16ERN11.65234679
17NEK61.63858596
18PDK31.62793267
19PDK41.62793267
20ARAF1.57733466
21TYRO31.57449802
22PLK21.51869259
23NTRK31.51348047
24FER1.47318791
25MAP3K41.45407335
26MAP3K121.40664619
27MST41.26890771
28EPHA31.26328667
29MAP3K21.26259091
30FRK1.22788812
31PKN11.20510013
32GRK51.19646052
33DAPK21.19387095
34MAP3K91.13069296
35TNIK1.11807575
36SGK2231.09611536
37SGK4941.09611536
38SGK21.08920893
39MYLK1.07957957
40MUSK1.03782655
41PAK31.03525974
42MAP2K71.03188223
43PKN21.02662767
44PTK21.02131036
45LATS21.00048996
46MAPKAPK30.99807860
47LATS10.99277416
48PDGFRA0.98881511
49CASK0.98385392
50TNK20.96146479
51TESK10.96124570
52CAMK10.94264918
53SGK30.94220481
54MAPK150.94052648
55MAP2K40.93320054
56EPHB10.92647305
57ERBB40.91512964
58NTRK10.89434732
59PDK20.87779010
60MAP2K10.87393772
61MAP2K20.87383493
62FGFR30.85989545
63LIMK10.85494295
64MAPK130.85487425
65DDR20.84404498
66FGR0.84154282
67BMX0.84012890
68MARK20.81781351
69PRKCG0.81174640
70PRKCE0.81146020
71FGFR40.80679232
72PDPK10.80402149
73PTK2B0.76821308
74ROCK10.72331145
75PAK40.71875542
76CAMK2G0.71839462
77MAPK120.71527719
78FGFR20.70957785
79PRKG20.70476589
80MET0.69211544
81MINK10.68197594
82MAP3K70.67619351
83DAPK30.67369355
84KSR20.67310213
85RET0.66007075
86WNK40.65293296
87STK380.64635325
88CDK50.64098162
89FGFR10.63788425
90MAPK100.62742096
91STK390.62701008
92PRKD10.61473172
93PDK10.61315286
94MAP3K130.60944090
95CAMK2A0.60802457
96CDK150.60265148
97PINK10.58889594
98FES0.56257809
99LRRK20.56254611
100MST1R0.55408599
101CDK180.55257014
102CDK140.55162644
103PRKCH0.55022977
104ICK0.54987844
105PRKG10.54712366
106RPS6KA30.51650791
107CDC42BPA0.50880533
108MAPKAPK50.49891519
109CDK11A0.49102662
110ALK0.49043795
111CAMK2B0.47943305
112CAMKK10.47517249
113PRPF4B0.47346742
114ROCK20.46834982
115MAPK70.46452127
116HIPK20.46310376
117WNK30.45463790
118SGK10.45422676
119CAMK2D0.43523791
120DYRK1A0.42977346
121CAMKK20.42533091
122ADRBK10.42126093
123PRKACA0.42041165
124STK38L0.41817772
125JAK10.41482136
126ERBB20.41013906
127STK110.39775707
128CSNK1G20.38712307
129PRKCA0.37920970
130PRKACG0.37789117
131PRKCZ0.37507447
132SRC0.37114862
133IGF1R0.36989997
134MAP2K60.34849197
135FYN0.33959836
136DAPK10.33908663
137DMPK0.33286105
138INSRR0.32751250
139TAOK20.31303046
140PRKCQ0.28679138

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.71243669
2Fatty acid biosynthesis_Homo sapiens_hsa000613.45949399
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.06003502
4Fatty acid degradation_Homo sapiens_hsa000712.97137905
5Fatty acid metabolism_Homo sapiens_hsa012122.93927111
6Synaptic vesicle cycle_Homo sapiens_hsa047212.73686772
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.43517705
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.35842743
9PPAR signaling pathway_Homo sapiens_hsa033202.08259524
10Propanoate metabolism_Homo sapiens_hsa006402.03963819
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03090771
12Arginine biosynthesis_Homo sapiens_hsa002201.77538473
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74828711
14Bile secretion_Homo sapiens_hsa049761.71356722
15Sulfur metabolism_Homo sapiens_hsa009201.68339163
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.65369347
17Butanoate metabolism_Homo sapiens_hsa006501.64626602
18Peroxisome_Homo sapiens_hsa041461.57776208
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52857425
20Tryptophan metabolism_Homo sapiens_hsa003801.50995721
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50101471
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49090280
23Long-term potentiation_Homo sapiens_hsa047201.47082294
24Fatty acid elongation_Homo sapiens_hsa000621.44867709
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42939609
26Dopaminergic synapse_Homo sapiens_hsa047281.36736016
27* Complement and coagulation cascades_Homo sapiens_hsa046101.35970819
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31176894
29Chemical carcinogenesis_Homo sapiens_hsa052041.29672727
30Collecting duct acid secretion_Homo sapiens_hsa049661.21051678
31Pyruvate metabolism_Homo sapiens_hsa006201.18872576
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16292104
33Vitamin digestion and absorption_Homo sapiens_hsa049771.12267601
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09564170
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07918147
36Biosynthesis of amino acids_Homo sapiens_hsa012301.07723826
37Carbon metabolism_Homo sapiens_hsa012001.06013731
38Serotonergic synapse_Homo sapiens_hsa047261.02449736
39Vibrio cholerae infection_Homo sapiens_hsa051101.01926967
40Glycerolipid metabolism_Homo sapiens_hsa005611.00627369
41beta-Alanine metabolism_Homo sapiens_hsa004101.00575733
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99884894
43Starch and sucrose metabolism_Homo sapiens_hsa005000.98160634
44Cholinergic synapse_Homo sapiens_hsa047250.96129103
45Steroid biosynthesis_Homo sapiens_hsa001000.91487167
46Retinol metabolism_Homo sapiens_hsa008300.90484454
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89650162
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.86858725
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.86656611
50Nicotine addiction_Homo sapiens_hsa050330.83889017
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83519565
52Calcium signaling pathway_Homo sapiens_hsa040200.83336753
53Oxytocin signaling pathway_Homo sapiens_hsa049210.83141262
54Long-term depression_Homo sapiens_hsa047300.82498329
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.81302965
56Gastric acid secretion_Homo sapiens_hsa049710.81026499
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80285830
58GABAergic synapse_Homo sapiens_hsa047270.78604671
59Estrogen signaling pathway_Homo sapiens_hsa049150.76915422
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.76633354
61Mineral absorption_Homo sapiens_hsa049780.76609728
62Arginine and proline metabolism_Homo sapiens_hsa003300.76599178
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.75316231
64Glutathione metabolism_Homo sapiens_hsa004800.75295865
65Vitamin B6 metabolism_Homo sapiens_hsa007500.73776536
66Histidine metabolism_Homo sapiens_hsa003400.73616933
67Insulin secretion_Homo sapiens_hsa049110.73578962
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73188964
69Taste transduction_Homo sapiens_hsa047420.73005277
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.72296462
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72030872
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70930864
73Gap junction_Homo sapiens_hsa045400.69513802
74Salivary secretion_Homo sapiens_hsa049700.67901917
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66662951
76Fructose and mannose metabolism_Homo sapiens_hsa000510.65220832
77Sulfur relay system_Homo sapiens_hsa041220.65152267
78Fat digestion and absorption_Homo sapiens_hsa049750.64590564
79ECM-receptor interaction_Homo sapiens_hsa045120.63961024
80Cocaine addiction_Homo sapiens_hsa050300.63786948
81Pentose phosphate pathway_Homo sapiens_hsa000300.62230698
82Arachidonic acid metabolism_Homo sapiens_hsa005900.61808674
83Phenylalanine metabolism_Homo sapiens_hsa003600.61119815
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60939957
85Folate biosynthesis_Homo sapiens_hsa007900.60670614
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60663636
87Pancreatic secretion_Homo sapiens_hsa049720.59891773
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59801345
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59667649
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58708558
91GnRH signaling pathway_Homo sapiens_hsa049120.57719303
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.57696754
93Circadian rhythm_Homo sapiens_hsa047100.57374089
94Thyroid hormone synthesis_Homo sapiens_hsa049180.56411597
95Glutamatergic synapse_Homo sapiens_hsa047240.54036055
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.52977898
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51300006
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50401087
99Glucagon signaling pathway_Homo sapiens_hsa049220.49787346
100Glioma_Homo sapiens_hsa052140.49231891
101Caffeine metabolism_Homo sapiens_hsa002320.48680804
102ABC transporters_Homo sapiens_hsa020100.48333257
103Olfactory transduction_Homo sapiens_hsa047400.48275343
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48078754
105Tyrosine metabolism_Homo sapiens_hsa003500.47953317
106Dorso-ventral axis formation_Homo sapiens_hsa043200.47573549
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44199366
108Linoleic acid metabolism_Homo sapiens_hsa005910.43591382
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41393415
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.40938467
111Other glycan degradation_Homo sapiens_hsa005110.40530483
112Sphingolipid metabolism_Homo sapiens_hsa006000.40386102
113Prion diseases_Homo sapiens_hsa050200.40340913
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40310781
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39992942
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38671735
117Insulin resistance_Homo sapiens_hsa049310.38213053
118Dilated cardiomyopathy_Homo sapiens_hsa054140.37823300
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37680080
120Protein digestion and absorption_Homo sapiens_hsa049740.35471742
121cAMP signaling pathway_Homo sapiens_hsa040240.35030287
122Tight junction_Homo sapiens_hsa045300.33975804
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32720040
124Lysine degradation_Homo sapiens_hsa003100.32687597
125Renin secretion_Homo sapiens_hsa049240.32075960
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31532434
127Circadian entrainment_Homo sapiens_hsa047130.31043060
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30647385
129Basal cell carcinoma_Homo sapiens_hsa052170.30456713
130Melanogenesis_Homo sapiens_hsa049160.28161616
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28040059
132Ether lipid metabolism_Homo sapiens_hsa005650.27875114
133Selenocompound metabolism_Homo sapiens_hsa004500.27848005
134Amphetamine addiction_Homo sapiens_hsa050310.26247303
135Lysosome_Homo sapiens_hsa041420.25789971
136Morphine addiction_Homo sapiens_hsa050320.25768494

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