CLTC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.94740639
2nuclear pore organization (GO:0006999)5.10703844
3synaptic vesicle maturation (GO:0016188)4.86486807
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.51566425
5layer formation in cerebral cortex (GO:0021819)4.30220666
6locomotory exploration behavior (GO:0035641)4.24059814
7pore complex assembly (GO:0046931)4.21619491
8COPII vesicle coating (GO:0048208)4.01430764
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97235660
10cell adhesion mediated by integrin (GO:0033627)3.78739282
11regulation of synaptic vesicle exocytosis (GO:2000300)3.74232868
12cytoskeletal anchoring at plasma membrane (GO:0007016)3.68735591
13synaptic vesicle exocytosis (GO:0016079)3.68201436
14glutamate secretion (GO:0014047)3.65221319
15mitotic sister chromatid cohesion (GO:0007064)3.63234294
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.56521063
17DNA unwinding involved in DNA replication (GO:0006268)3.55089496
18proline transport (GO:0015824)3.53765868
19mitotic chromosome condensation (GO:0007076)3.53475222
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.52682618
21regulation of RNA export from nucleus (GO:0046831)3.52459348
22regulation of clathrin-mediated endocytosis (GO:2000369)3.51196610
23vesicle transport along microtubule (GO:0047496)3.50854213
24activation of protein kinase A activity (GO:0034199)3.43394899
25protein retention in ER lumen (GO:0006621)3.42363145
26protein localization to endosome (GO:0036010)3.37893771
27clathrin coat assembly (GO:0048268)3.37448446
28regulation of nucleobase-containing compound transport (GO:0032239)3.35503754
29sodium ion export (GO:0071436)3.32999161
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.31549678
31establishment of nucleus localization (GO:0040023)3.25292251
32cellular potassium ion homeostasis (GO:0030007)3.24631113
33vocalization behavior (GO:0071625)3.23128820
34cellular protein complex localization (GO:0034629)3.22393386
35adherens junction assembly (GO:0034333)3.16074317
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10942602
37exploration behavior (GO:0035640)3.10433066
38regulation of translational fidelity (GO:0006450)3.09385194
39neurotransmitter secretion (GO:0007269)3.07867408
40dendrite morphogenesis (GO:0048813)3.07616751
41regulation of ARF protein signal transduction (GO:0032012)3.06700446
42regulation of synaptic vesicle transport (GO:1902803)3.06082454
43protein complex localization (GO:0031503)3.01987513
44regulation of centriole replication (GO:0046599)3.00335464
45desmosome organization (GO:0002934)3.00206591
46paraxial mesoderm development (GO:0048339)2.99846138
47G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99259502
48organelle transport along microtubule (GO:0072384)2.98752355
49regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98462921
50neuromuscular process controlling balance (GO:0050885)2.97255156
51cerebellar Purkinje cell layer development (GO:0021680)2.97235825
52regulation of glutamate receptor signaling pathway (GO:1900449)2.96935567
53hemidesmosome assembly (GO:0031581)2.96022801
54focal adhesion assembly (GO:0048041)2.95337860
55cell-substrate adherens junction assembly (GO:0007045)2.95337860
56skin morphogenesis (GO:0043589)2.95024725
57cell-substrate junction assembly (GO:0007044)2.94121293
58negative regulation of DNA repair (GO:0045738)2.94094578
59negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92929800
60regulation of synapse structural plasticity (GO:0051823)2.92742653
61activation of Rac GTPase activity (GO:0032863)2.92695578
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.92196412
63regulation of mitotic spindle organization (GO:0060236)2.90657580
64nerve growth factor signaling pathway (GO:0038180)2.89895132
65dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.89215982
66protein export from nucleus (GO:0006611)2.88550698
67embryonic process involved in female pregnancy (GO:0060136)2.84061232
68regulation of long-term neuronal synaptic plasticity (GO:0048169)2.80949912
69regulation of neuronal synaptic plasticity (GO:0048168)2.77178966
70plasma membrane repair (GO:0001778)2.76251167
71sister chromatid segregation (GO:0000819)2.75913673
72COPI coating of Golgi vesicle (GO:0048205)2.75186420
73Golgi transport vesicle coating (GO:0048200)2.75186420
74epithelial cell-cell adhesion (GO:0090136)2.72751288
75positive regulation of fibroblast migration (GO:0010763)2.72009976
76mitotic cytokinesis (GO:0000281)2.70414229
77cell communication by electrical coupling (GO:0010644)2.70074712
78protein targeting to Golgi (GO:0000042)2.69379423
79protein localization to microtubule (GO:0035372)2.66805187
80mating behavior (GO:0007617)2.66748969
81regulation of sister chromatid cohesion (GO:0007063)2.66283918
82cytoskeleton-dependent cytokinesis (GO:0061640)2.66019816
83dendritic spine morphogenesis (GO:0060997)2.65885037
84branching involved in mammary gland duct morphogenesis (GO:0060444)2.64942521
85NLS-bearing protein import into nucleus (GO:0006607)2.63089901
86mammary gland epithelial cell proliferation (GO:0033598)2.61920967
87positive regulation of synapse maturation (GO:0090129)2.61750774
88regulation of histone H3-K27 methylation (GO:0061085)2.59784706
89regulation of glucose import in response to insulin stimulus (GO:2001273)2.58882952
90innervation (GO:0060384)2.58803872
91embryonic camera-type eye morphogenesis (GO:0048596)2.58707758
92cerebellar Purkinje cell differentiation (GO:0021702)2.58670016
93establishment of protein localization to Golgi (GO:0072600)2.58519628
94mitotic sister chromatid segregation (GO:0000070)2.58222104
95activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.57363446
96iron ion import (GO:0097286)2.56363752
97axon extension (GO:0048675)2.55965323
98protein localization to synapse (GO:0035418)2.54384516
99DNA duplex unwinding (GO:0032508)2.53950460
100synaptic vesicle endocytosis (GO:0048488)2.52928013
101ER-nucleus signaling pathway (GO:0006984)2.52703105
102glucocorticoid receptor signaling pathway (GO:0042921)2.52460157
103ER overload response (GO:0006983)2.52149594
104positive regulation of nuclease activity (GO:0032075)2.51969774
105cell migration in hindbrain (GO:0021535)2.51005114
106regulation of mammary gland epithelial cell proliferation (GO:0033599)2.50950742
107endoplasmic reticulum unfolded protein response (GO:0030968)2.50247024
108insulin-like growth factor receptor signaling pathway (GO:0048009)2.49866819
109cytoplasmic mRNA processing body assembly (GO:0033962)2.49086450
110alanine transport (GO:0032328)2.48126489
111axon cargo transport (GO:0008088)2.47919180
112membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.47278213
113axonal fasciculation (GO:0007413)2.46797099
114regulation of dendritic spine morphogenesis (GO:0061001)2.46582156
115hippo signaling (GO:0035329)2.46481308
116retina vasculature morphogenesis in camera-type eye (GO:0061299)2.45090955
117neuron recognition (GO:0008038)2.43493883
118macroautophagy (GO:0016236)2.43441928
119regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.41493238
120gamma-aminobutyric acid transport (GO:0015812)2.41428694
121vesicle coating (GO:0006901)2.40503182
122embryonic eye morphogenesis (GO:0048048)2.39346698
123proline biosynthetic process (GO:0006561)2.38863309
124neuron projection extension (GO:1990138)2.38494801
125retrograde transport, vesicle recycling within Golgi (GO:0000301)2.37296396
126ionotropic glutamate receptor signaling pathway (GO:0035235)2.37260239
127spliceosomal tri-snRNP complex assembly (GO:0000244)2.36209903
128membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.36000443
129chondrocyte development (GO:0002063)2.35831918
130DNA geometric change (GO:0032392)2.35698507
131positive regulation of axon extension (GO:0045773)2.35610789
132retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.35399478
133suckling behavior (GO:0001967)2.34616034
134negative regulation of fatty acid transport (GO:2000192)2.33697878
135response to nerve growth factor (GO:1990089)2.33654287
136cellular response to nerve growth factor stimulus (GO:1990090)2.33654287
137protein localization to chromosome, centromeric region (GO:0071459)2.33488508
138Golgi organization (GO:0007030)2.32526003
139potassium ion import (GO:0010107)2.32032537
140positive regulation of cellular response to insulin stimulus (GO:1900078)2.31424642
141cellular zinc ion homeostasis (GO:0006882)2.31153483
142cellular response to unfolded protein (GO:0034620)2.29927572
143membrane disassembly (GO:0030397)2.28913720
144nuclear envelope disassembly (GO:0051081)2.28913720
145regulation of nuclease activity (GO:0032069)2.28749097
146maternal placenta development (GO:0001893)2.28699754
147stress fiber assembly (GO:0043149)2.28662151
148asymmetric protein localization (GO:0008105)2.27342154
149semaphorin-plexin signaling pathway (GO:0071526)2.27306082
150regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.27241466
151regulation of ARF GTPase activity (GO:0032312)2.25966385
152neurotransmitter transport (GO:0006836)2.25597179
153regulation of Rac protein signal transduction (GO:0035020)2.25504689
154mitotic nuclear envelope disassembly (GO:0007077)2.24967727
155regulation of synaptic plasticity (GO:0048167)2.24955390
156negative regulation of dendrite morphogenesis (GO:0050774)2.24167957
157positive regulation of keratinocyte differentiation (GO:0045618)2.23491084
158cellular sodium ion homeostasis (GO:0006883)2.22993884
159long-term memory (GO:0007616)2.22766900
160regulation of early endosome to late endosome transport (GO:2000641)2.22763025
161regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.22653452
162regulation of glucocorticoid metabolic process (GO:0031943)2.22574916
163positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.22553373
164apical protein localization (GO:0045176)2.22321908
165regulation of NFAT protein import into nucleus (GO:0051532)2.22116565
166neuron cell-cell adhesion (GO:0007158)2.21363221
167nucleobase-containing small molecule interconversion (GO:0015949)2.21133565
168inner ear receptor cell development (GO:0060119)2.20934295
169glycine transport (GO:0015816)2.20700200
170neuronal ion channel clustering (GO:0045161)2.20025995
171long-term synaptic potentiation (GO:0060291)2.19913216
172cell communication involved in cardiac conduction (GO:0086065)2.19260319
173gap junction assembly (GO:0016264)2.18749871
174corticosteroid receptor signaling pathway (GO:0031958)2.18141656
175membrane repolarization during action potential (GO:0086011)2.18040936
176neuronal action potential propagation (GO:0019227)2.17779696
177negative regulation of sodium ion transport (GO:0010766)2.17283267
178prepulse inhibition (GO:0060134)2.17224602
179regulation of transforming growth factor beta2 production (GO:0032909)2.16899587
180synapse organization (GO:0050808)2.16470329
181regulation of spindle organization (GO:0090224)2.16442273
182receptor catabolic process (GO:0032801)2.15756051
183mesodermal cell differentiation (GO:0048333)2.15710552
184positive regulation of protein localization to plasma membrane (GO:1903078)2.14663431
185peptidyl-threonine phosphorylation (GO:0018107)2.14659654
186regulation of translational termination (GO:0006449)2.14188580
187basement membrane organization (GO:0071711)2.14044717

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.43448187
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.09682952
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.94087293
4AR_21909140_ChIP-Seq_LNCAP_Human3.43872365
5EZH2_22144423_ChIP-Seq_EOC_Human2.78616401
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57063230
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51622779
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44468419
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43433840
10PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.33618734
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33311201
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.25421975
13* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.22749664
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.22167772
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12114190
16TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.07922525
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07701445
18* RARB_27405468_Chip-Seq_BRAIN_Mouse2.06383191
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01388617
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98708192
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.97964065
22* DROSHA_22980978_ChIP-Seq_HELA_Human1.96623718
23GBX2_23144817_ChIP-Seq_PC3_Human1.96330602
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93122527
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89356436
26* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84556011
27* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.80623108
28* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.80418872
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.78748220
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74402892
31* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74279225
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72904483
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72904483
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.72097649
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69689467
36MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68378427
37* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67252875
38* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67252875
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65333847
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62484166
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62344929
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61426245
43TP53_16413492_ChIP-PET_HCT116_Human1.60369108
44KDM2B_26808549_Chip-Seq_K562_Human1.58871413
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.57818089
46REST_21632747_ChIP-Seq_MESCs_Mouse1.55060909
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54709694
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54692294
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.54601463
50E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53563790
51AR_21572438_ChIP-Seq_LNCaP_Human1.53388978
52* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52491745
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.51375883
54* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.50619484
55* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49096679
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47604253
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47296063
58* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47145808
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45312177
60* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45012723
61* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44820121
62* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44621258
63* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43949397
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42715670
65* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42605470
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42196389
67AHR_22903824_ChIP-Seq_MCF-7_Human1.41886284
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41807071
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41077671
70CHD1_26751641_Chip-Seq_LNCaP_Human1.40912697
71SMAD4_21799915_ChIP-Seq_A2780_Human1.40192517
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.40041676
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39811925
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.39486474
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.38320105
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37617500
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36275880
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35930642
79* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35311222
80* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35293983
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.34842756
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.34787289
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34774086
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.34760675
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32828338
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31546638
87ZNF274_21170338_ChIP-Seq_K562_Hela1.31259047
88* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30558968
89RACK7_27058665_Chip-Seq_MCF-7_Human1.30369367
90AR_19668381_ChIP-Seq_PC3_Human1.29592534
91* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29550859
92* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29050857
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28153594
94ZNF263_19887448_ChIP-Seq_K562_Human1.28014703
95GATA1_22025678_ChIP-Seq_K562_Human1.27468601
96* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26923062
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25859233
98REST_18959480_ChIP-ChIP_MESCs_Mouse1.24212893
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24175300
100ATF3_27146783_Chip-Seq_COLON_Human1.23516948
101* STAT3_23295773_ChIP-Seq_U87_Human1.23014275
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22123236
103* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22094978
104* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21673763
105* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21140964
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19147336
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18428288
108* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18062255
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17964763
110* TFEB_21752829_ChIP-Seq_HELA_Human1.17562072
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.17350147
112RUNX1_27514584_Chip-Seq_MCF-7_Human1.16937258
113* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15785181
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15148766
115CLOCK_20551151_ChIP-Seq_293T_Human1.14813593
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14646947
117BRD4_25478319_ChIP-Seq_HGPS_Human1.14481074
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13535287
119EED_16625203_ChIP-ChIP_MESCs_Mouse1.13411628
120GATA3_24758297_ChIP-Seq_MCF-7_Human1.13261049
121* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13144707
122PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13139538
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13089097
124P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12970735
125NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.12807674
126KDM2B_26808549_Chip-Seq_DND41_Human1.12338091
127RXR_22108803_ChIP-Seq_LS180_Human1.11421287
128* SOX17_20123909_ChIP-Seq_XEN_Mouse1.10972316
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10580401
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10451750
131* UBF1/2_26484160_Chip-Seq_HMECs_Human1.10084257
132EZH2_27304074_Chip-Seq_ESCs_Mouse1.09737797
133SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09616536
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.09030283
135* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08956635
136SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08675566
137FOXO3_23340844_ChIP-Seq_DLD1_Human1.08460631
138EZH2_27294783_Chip-Seq_ESCs_Mouse1.08323924
139GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06993987
140EP300_21415370_ChIP-Seq_HL-1_Mouse1.06870393
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05874920
142MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05781170
143RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05604705
144ESR1_20079471_ChIP-ChIP_T-47D_Human1.05285198
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04553615
146ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.03313407
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02764104
148* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02709160
149HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02572207
150IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01345872
151STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01002986
152ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00927479
153KDM2B_26808549_Chip-Seq_JURKAT_Human1.00604726
154* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00193754
155SMAD3_21741376_ChIP-Seq_EPCs_Human0.99773695
156FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99398479
157SMAD3_21741376_ChIP-Seq_ESCs_Human0.99191372
158* GATA6_25053715_ChIP-Seq_YYC3_Human0.98937435
159TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98781610
160SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98512665
161* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97943313
162* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97943313
163TCF4_23295773_ChIP-Seq_U87_Human0.97096173
164ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97019923
165TCF4_18268006_ChIP-ChIP_LS174T_Human0.96694827
166AR_25329375_ChIP-Seq_VCAP_Human0.96598909
167ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96591056
168ESR2_21235772_ChIP-Seq_MCF-7_Human0.95739321
169NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92858511
170* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92201233
171NANOG_21062744_ChIP-ChIP_HESCs_Human0.91706834
172* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90481894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.01350481
2MP0000569_abnormal_digit_pigmentation3.58272375
3MP0010234_abnormal_vibrissa_follicle3.36097505
4MP0009780_abnormal_chondrocyte_physiolo3.16314040
5MP0003705_abnormal_hypodermis_morpholog3.03804586
6MP0004270_analgesia2.93983060
7MP0003635_abnormal_synaptic_transmissio2.92191744
8MP0003941_abnormal_skin_development2.63490882
9MP0004858_abnormal_nervous_system2.38338489
10MP0003300_gastrointestinal_ulcer2.37087923
11MP0002909_abnormal_adrenal_gland2.30771619
12MP0002063_abnormal_learning/memory/cond2.25243248
13MP0009046_muscle_twitch2.20070582
14MP0005623_abnormal_meninges_morphology2.19564399
15MP0005409_darkened_coat_color2.10906089
16MP0002877_abnormal_melanocyte_morpholog2.01466392
17MP0002064_seizures1.99323045
18MP0008057_abnormal_DNA_replication1.98895032
19MP0003172_abnormal_lysosome_physiology1.96180919
20MP0009745_abnormal_behavioral_response1.96156514
21MP0004264_abnormal_extraembryonic_tissu1.88984872
22MP0002734_abnormal_mechanical_nocicepti1.86960066
23MP0000013_abnormal_adipose_tissue1.86575192
24MP0003283_abnormal_digestive_organ1.82309214
25MP0004957_abnormal_blastocyst_morpholog1.81292335
26MP0005257_abnormal_intraocular_pressure1.79240879
27MP0004272_abnormal_basement_membrane1.77220015
28MP0010352_gastrointestinal_tract_polyps1.75974785
29MP0005076_abnormal_cell_differentiation1.75969878
30MP0003329_amyloid_beta_deposits1.70579390
31MP0002009_preneoplasia1.69501889
32MP0008438_abnormal_cutaneous_collagen1.68555879
33MP0004811_abnormal_neuron_physiology1.67863355
34MP0003880_abnormal_central_pattern1.66507820
35MP0002796_impaired_skin_barrier1.65776873
36MP0003303_peritoneal_inflammation1.64715761
37MP0001968_abnormal_touch/_nociception1.63105690
38MP0010678_abnormal_skin_adnexa1.61765533
39MP0002733_abnormal_thermal_nociception1.57640655
40MP0002572_abnormal_emotion/affect_behav1.56994741
41MP0003111_abnormal_nucleus_morphology1.53296438
42MP0002735_abnormal_chemical_nociception1.52141352
43MP0001299_abnormal_eye_distance/1.50703499
44MP0008961_abnormal_basal_metabolism1.49842092
45MP0002060_abnormal_skin_morphology1.49541133
46MP0001730_embryonic_growth_arrest1.47376556
47MP0005451_abnormal_body_composition1.41082142
48MP0003045_fibrosis1.41028376
49MP0002184_abnormal_innervation1.40584645
50MP0000604_amyloidosis1.40081422
51MP0003091_abnormal_cell_migration1.40076565
52MP0009672_abnormal_birth_weight1.39073979
53MP0000462_abnormal_digestive_system1.38257306
54MP0003122_maternal_imprinting1.36476816
55MP0003183_abnormal_peptide_metabolism1.32215342
56MP0002086_abnormal_extraembryonic_tissu1.31896040
57MP0004885_abnormal_endolymph1.31392251
58MP0001672_abnormal_embryogenesis/_devel1.31154107
59MP0005380_embryogenesis_phenotype1.31154107
60MP0003690_abnormal_glial_cell1.30274406
61MP0005501_abnormal_skin_physiology1.28171013
62MP0001440_abnormal_grooming_behavior1.27972286
63MP0003984_embryonic_growth_retardation1.27736858
64MP0000778_abnormal_nervous_system1.26893070
65MP0001970_abnormal_pain_threshold1.26494756
66MP0000955_abnormal_spinal_cord1.26128718
67MP0003191_abnormal_cellular_cholesterol1.26124586
68MP0003693_abnormal_embryo_hatching1.25372793
69MP0010386_abnormal_urinary_bladder1.24611284
70MP0002088_abnormal_embryonic_growth/wei1.24605000
71MP0001915_intracranial_hemorrhage1.24321992
72MP0003633_abnormal_nervous_system1.24076613
73MP0000627_abnormal_mammary_gland1.22220394
74MP0005386_behavior/neurological_phenoty1.22047526
75MP0004924_abnormal_behavior1.22047526
76MP0010094_abnormal_chromosome_stability1.21724962
77MP0003077_abnormal_cell_cycle1.21188382
78MP0000350_abnormal_cell_proliferation1.20569257
79MP0003453_abnormal_keratinocyte_physiol1.20546640
80MP0003632_abnormal_nervous_system1.20506952
81MP0002896_abnormal_bone_mineralization1.19881445
82MP0003634_abnormal_glial_cell1.19695039
83MP0005408_hypopigmentation1.19542187
84MP0003950_abnormal_plasma_membrane1.18395029
85MP0008932_abnormal_embryonic_tissue1.17513521
86MP0002084_abnormal_developmental_patter1.17409200
87MP0008569_lethality_at_weaning1.17368312
88MP0002067_abnormal_sensory_capabilities1.16159257
89MP0001486_abnormal_startle_reflex1.15773171
90MP0001697_abnormal_embryo_size1.13559141
91MP0005621_abnormal_cell_physiology1.12999962
92MP0002080_prenatal_lethality1.12104334
93MP0003787_abnormal_imprinting1.11594455
94MP0004233_abnormal_muscle_weight1.11527418
95MP0002736_abnormal_nociception_after1.11266772
96MP0005171_absent_coat_pigmentation1.10993387
97MP0002090_abnormal_vision1.10350619
98MP0003631_nervous_system_phenotype1.10157998
99MP0005058_abnormal_lysosome_morphology1.09936785
100MP0000003_abnormal_adipose_tissue1.09632346
101MP0005187_abnormal_penis_morphology1.09450559
102MP0004145_abnormal_muscle_electrophysio1.09332423
103MP0002272_abnormal_nervous_system1.09199466
104MP0010307_abnormal_tumor_latency1.09132919
105MP0005275_abnormal_skin_tensile1.08964301
106MP0000579_abnormal_nail_morphology1.08891405
107MP0003868_abnormal_feces_composition1.07693291
108MP0004782_abnormal_surfactant_physiolog1.06760116
109MP0003566_abnormal_cell_adhesion1.06175576
110MP0003890_abnormal_embryonic-extraembry1.05804302
111MP0001501_abnormal_sleep_pattern1.04721511
112MP0005167_abnormal_blood-brain_barrier1.03765832
113MP0002557_abnormal_social/conspecific_i1.03206670
114MP0002882_abnormal_neuron_morphology1.00576137
115MP0002085_abnormal_embryonic_tissue1.00258402
116MP0002098_abnormal_vibrissa_morphology0.99472208
117MP0001177_atelectasis0.98928233
118MP0001661_extended_life_span0.98335718
119MP0003385_abnormal_body_wall0.97680550
120MP0000377_abnormal_hair_follicle0.97415925
121MP0001348_abnormal_lacrimal_gland0.96611893
122MP0002697_abnormal_eye_size0.96154930
123MP0005423_abnormal_somatic_nervous0.95381446
124MP0000383_abnormal_hair_follicle0.94890038
125MP0008007_abnormal_cellular_replicative0.94251247
126MP0009697_abnormal_copulation0.94222203
127MP0000733_abnormal_muscle_development0.93730908
128MP0003942_abnormal_urinary_system0.93525609
129MP0004197_abnormal_fetal_growth/weight/0.92548705
130MP0002066_abnormal_motor_capabilities/c0.92491709
131MP0002152_abnormal_brain_morphology0.91599223
132MP0009703_decreased_birth_body0.90453525
133MP0003115_abnormal_respiratory_system0.90228987
134MP0003279_aneurysm0.88722848
135MP0005384_cellular_phenotype0.88430958
136MP0005023_abnormal_wound_healing0.87464502
137MP0006054_spinal_hemorrhage0.87380411
138MP0003123_paternal_imprinting0.85833386
139MP0004130_abnormal_muscle_cell0.84561121
140MP0002092_abnormal_eye_morphology0.83882158
141MP0001216_abnormal_epidermal_layer0.83013918
142MP0001958_emphysema0.82243292
143MP0001849_ear_inflammation0.82166589
144MP0000762_abnormal_tongue_morphology0.81881986
145MP0000537_abnormal_urethra_morphology0.80770439
146MP0010368_abnormal_lymphatic_system0.80464207
147MP0008260_abnormal_autophagy0.79417126
148MP0009053_abnormal_anal_canal0.77923349
149MP0003075_altered_response_to0.77673868
150MP0003935_abnormal_craniofacial_develop0.77505570
151MP0001881_abnormal_mammary_gland0.75621483
152MP0003879_abnormal_hair_cell0.74278843
153MP0004808_abnormal_hematopoietic_stem0.73631175
154MP0005248_abnormal_Harderian_gland0.72663892
155MP0003121_genomic_imprinting0.72253835
156MP0000432_abnormal_head_morphology0.72239760
157MP0000467_abnormal_esophagus_morphology0.72188249
158MP0000534_abnormal_ureter_morphology0.67294006
159MP0002229_neurodegeneration0.66224003
160MP0004185_abnormal_adipocyte_glucose0.66018757
161MP0000747_muscle_weakness0.65001927
162MP0004510_myositis0.63931406
163MP0000428_abnormal_craniofacial_morphol0.62687830
164MP0000516_abnormal_urinary_system0.62684672
165MP0005367_renal/urinary_system_phenotyp0.62684672
166MP0004085_abnormal_heartbeat0.61610996
167MP0001943_abnormal_respiration0.59172730

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.56294568
2Asymmetry of the thorax (HP:0001555)3.55359108
3Cerebral aneurysm (HP:0004944)3.35486664
4Papilledema (HP:0001085)3.26026378
5Visual hallucinations (HP:0002367)3.17277405
6Focal seizures (HP:0007359)3.08534361
7Insidious onset (HP:0003587)2.99159136
8Termporal pattern (HP:0011008)2.99159136
9Action tremor (HP:0002345)2.92162653
10Osteolytic defects of the phalanges of the hand (HP:0009771)2.88462892
11Osteolytic defects of the hand bones (HP:0009699)2.88462892
12Macroorchidism (HP:0000053)2.82727324
13Supranuclear gaze palsy (HP:0000605)2.80620263
14Myokymia (HP:0002411)2.70738644
15Subacute progressive viral hepatitis (HP:0006572)2.66887755
16Resting tremor (HP:0002322)2.63473020
17Focal motor seizures (HP:0011153)2.62768014
18Overgrowth (HP:0001548)2.58466239
19Short nail (HP:0001799)2.57110140
20Protrusio acetabuli (HP:0003179)2.50944213
21Flat acetabular roof (HP:0003180)2.46981710
22Cerebral inclusion bodies (HP:0100314)2.41901987
23Syringomyelia (HP:0003396)2.40022865
24Spinal cord lesions (HP:0100561)2.40022865
25Inappropriate behavior (HP:0000719)2.34574578
26Abnormality of the lower motor neuron (HP:0002366)2.33004688
27Deep philtrum (HP:0002002)2.32858282
28Shallow orbits (HP:0000586)2.31883315
29Atonic seizures (HP:0010819)2.31688928
30Apathy (HP:0000741)2.28136822
31Microglossia (HP:0000171)2.27736779
32Increased cerebral lipofuscin (HP:0011813)2.25598898
33Mutism (HP:0002300)2.24287920
34Urinary bladder sphincter dysfunction (HP:0002839)2.21570976
35Depression (HP:0000716)2.21224001
36Ankyloglossia (HP:0010296)2.18946201
37Disinhibition (HP:0000734)2.15887982
38Vertebral arch anomaly (HP:0008438)2.15636679
39Ulnar bowing (HP:0003031)2.15608995
40Truncal ataxia (HP:0002078)2.13879371
41Absence seizures (HP:0002121)2.13750531
42Hand muscle atrophy (HP:0009130)2.10379448
43Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.09503571
44Urinary urgency (HP:0000012)2.09224379
45Ankle clonus (HP:0011448)2.09057442
46Relative macrocephaly (HP:0004482)2.06317509
47Diminished motivation (HP:0000745)2.06180317
48Progressive cerebellar ataxia (HP:0002073)2.05727904
49Buphthalmos (HP:0000557)2.05081325
50Distal upper limb amyotrophy (HP:0007149)2.04650643
51Upper limb amyotrophy (HP:0009129)2.04650643
52Wormian bones (HP:0002645)2.04526541
53Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04305963
54Vertebral compression fractures (HP:0002953)2.04258147
55Enlarged penis (HP:0000040)2.03809713
56Wrist flexion contracture (HP:0001239)2.02687607
57Impaired vibration sensation in the lower limbs (HP:0002166)2.02380577
58Postural instability (HP:0002172)2.00505473
59Striae distensae (HP:0001065)2.00315635
60Increased nuchal translucency (HP:0010880)2.00294436
61Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.99255690
62Ankle contracture (HP:0006466)1.97858842
63Drooling (HP:0002307)1.97709489
64Excessive salivation (HP:0003781)1.97709489
65Missing ribs (HP:0000921)1.97396826
66Aortic aneurysm (HP:0004942)1.96479086
67Broad face (HP:0000283)1.96114108
68Pointed chin (HP:0000307)1.94759237
69Mitral valve prolapse (HP:0001634)1.94655500
70Hypopigmentation of the fundus (HP:0007894)1.94618817
71Abnormality of the distal phalanx of the thumb (HP:0009617)1.94450901
72Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94041663
73Atrophic scars (HP:0001075)1.93933832
74Arterial tortuosity (HP:0005116)1.93805439
75Micronodular cirrhosis (HP:0001413)1.93548482
76Generalized tonic-clonic seizures (HP:0002069)1.93521061
77Back pain (HP:0003418)1.93186199
78Chromsome breakage (HP:0040012)1.91993231
79Thyroid carcinoma (HP:0002890)1.91492064
80Impaired smooth pursuit (HP:0007772)1.91199791
81Agitation (HP:0000713)1.90912933
82Epileptic encephalopathy (HP:0200134)1.89921424
83Leiomyosarcoma (HP:0100243)1.89563193
84Uterine leiomyosarcoma (HP:0002891)1.89563193
85Hematochezia (HP:0002573)1.89491055
86Deviation of the thumb (HP:0009603)1.89485030
87Tetraparesis (HP:0002273)1.89236288
88Abnormality of oral frenula (HP:0000190)1.88924909
89Genetic anticipation (HP:0003743)1.88842926
90Spinal cord compression (HP:0002176)1.88627002
91Dilatation of the ascending aorta (HP:0005111)1.88530729
92Abnormality of the distal phalanges of the toes (HP:0010182)1.88187711
93J-shaped sella turcica (HP:0002680)1.87279934
94Aqueductal stenosis (HP:0002410)1.87213308
95Advanced eruption of teeth (HP:0006288)1.86859225
96Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.85706159
97Neuronal loss in central nervous system (HP:0002529)1.85654189
98Mitral stenosis (HP:0001718)1.85555531
99Dysmetric saccades (HP:0000641)1.85085072
100Dialeptic seizures (HP:0011146)1.85024171
101Abnormal foot bone ossification (HP:0010675)1.84573652
102Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84118350
103Hemiplegia (HP:0002301)1.83968180
104Aneurysm (HP:0002617)1.83596844
105Hypercortisolism (HP:0001578)1.83101210
106Cervical subluxation (HP:0003308)1.82654154
107Lower limb amyotrophy (HP:0007210)1.82472523
108Insomnia (HP:0100785)1.81050884
109Vascular tortuosity (HP:0004948)1.80277484
110Impaired social interactions (HP:0000735)1.79481517
111Abnormal social behavior (HP:0012433)1.79481517
112Curly hair (HP:0002212)1.78886093
113Amyotrophic lateral sclerosis (HP:0007354)1.78541458
114Bladder diverticulum (HP:0000015)1.78314389
115Astrocytoma (HP:0009592)1.78285203
116Abnormality of the astrocytes (HP:0100707)1.78285203
117Sparse lateral eyebrow (HP:0005338)1.77947926
118Bowel diverticulosis (HP:0005222)1.77513283
119Septate vagina (HP:0001153)1.77269388
120Abnormality of binocular vision (HP:0011514)1.76695589
121Diplopia (HP:0000651)1.76695589
122Abnormality of the corticospinal tract (HP:0002492)1.76451622
123Genu recurvatum (HP:0002816)1.75707694
124Right ventricular cardiomyopathy (HP:0011663)1.74755663
125Germ cell neoplasia (HP:0100728)1.74676290
126Dysdiadochokinesis (HP:0002075)1.74467829
127Increased CSF protein (HP:0002922)1.73759136
128Intention tremor (HP:0002080)1.73318158
129Arnold-Chiari malformation (HP:0002308)1.71759153
130Abnormality of ocular smooth pursuit (HP:0000617)1.70207728
131Patellar dislocation (HP:0002999)1.70206412
132Absent frontal sinuses (HP:0002688)1.69961094
133Aortic dissection (HP:0002647)1.69933311
134Distal lower limb amyotrophy (HP:0008944)1.68794670
135Transitional cell carcinoma of the bladder (HP:0006740)1.68782010
136Hyperacusis (HP:0010780)1.67875593
137Malignant gastrointestinal tract tumors (HP:0006749)1.66763837
138Gastrointestinal carcinoma (HP:0002672)1.66763837
139Fragile skin (HP:0001030)1.66608120
140Selective tooth agenesis (HP:0001592)1.66344235
141Orthostatic hypotension (HP:0001278)1.65958462
142Cortical dysplasia (HP:0002539)1.65051734
143Poor eye contact (HP:0000817)1.64855889
144Overriding aorta (HP:0002623)1.64406416
145Neurofibrillary tangles (HP:0002185)1.64317938
146Heterotopia (HP:0002282)1.64229925
147Hammertoe (HP:0001765)1.64169912
148Overlapping toe (HP:0001845)1.63822381
149Intellectual disability, profound (HP:0002187)1.63511429
150Renal duplication (HP:0000075)1.63506541
151Lower limb asymmetry (HP:0100559)1.63453637
152Elfin facies (HP:0004428)1.63236959
153Lower limb muscle weakness (HP:0007340)1.62700318
154Hyperparathyroidism (HP:0000843)1.62595226
155Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62208404
156Esophageal varix (HP:0002040)1.62064290
157Achilles tendon contracture (HP:0001771)1.61861302
158Menstrual irregularities (HP:0000858)1.61431270
159Bladder carcinoma (HP:0002862)1.60778360
160Bladder neoplasm (HP:0009725)1.60778360
161Natal tooth (HP:0000695)1.60141020
162Hypoventilation (HP:0002791)1.59677583
163Rapidly progressive (HP:0003678)1.59431685
164Megalencephaly (HP:0001355)1.58915295
165Papillary thyroid carcinoma (HP:0002895)1.58800601
166Spastic diplegia (HP:0001264)1.58726772
167Febrile seizures (HP:0002373)1.58589746
168Proximal placement of thumb (HP:0009623)1.58069170
169Turricephaly (HP:0000262)1.57713445
170Spinal rigidity (HP:0003306)1.57643938
171Lymphangioma (HP:0100764)1.56066478
172Global brain atrophy (HP:0002283)1.54904742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.73050872
2NTRK33.36386797
3MARK12.65147080
4MST1R2.42639015
5MAP3K42.42427993
6NTRK12.41718952
7MAP3K22.41280492
8KSR22.39829071
9EIF2AK12.27867066
10MINK12.20618775
11EPHA22.16362484
12RIPK12.13337442
13PBK2.09499275
14FRK2.05291897
15SMG12.03088609
16PAK62.02309283
17CAMKK12.00103971
18TSSK61.96276376
19SIK11.89679470
20PRKD31.89531192
21TRIB31.84948576
22PKN21.84060191
23PAK41.74084364
24RET1.71667794
25PDGFRA1.67573153
26TTK1.67273700
27DAPK21.66669408
28CAMK1G1.60191987
29NEK61.57296181
30EPHA41.52744628
31FGFR41.51198975
32RPS6KB21.50490561
33LATS21.46759367
34LMTK21.45361033
35ALK1.43473335
36KSR11.43088311
37BRD41.41881783
38SIK21.38505147
39FER1.35886798
40CAMK1D1.35304667
41MAP2K41.33656992
42PLK21.29846139
43ERBB41.29300005
44RIPK41.28524497
45IRAK31.27797703
46PTK61.26874697
47NTRK21.20083685
48CAMKK21.19281143
49NEK91.16452674
50EIF2AK31.15605720
51CDK51.15134586
52PNCK1.13220991
53MAP3K121.12898526
54PRKCH1.11217786
55SRPK11.10371612
56NEK11.07920591
57TYRO31.07026011
58DDR21.06733858
59PRPF4B1.03207511
60SGK30.99868362
61STK380.99862625
62PAK30.98577038
63BMX0.98111394
64PIK3CA0.96981346
65CDK120.96687351
66LATS10.95693808
67FGFR20.95101484
68TTN0.91002690
69EEF2K0.89658524
70FGFR30.89562743
71PTK20.88661158
72WNK10.85029302
73PDGFRB0.83006397
74TRPM70.79656575
75MAP2K70.78969623
76DMPK0.77970700
77STK110.77533044
78NME20.76615745
79RPS6KB10.76539599
80CDK70.76189534
81TESK10.76187068
82WEE10.73928864
83SGK20.69306240
84MAP3K10.69213958
85CSNK1G20.68822827
86MAP3K80.68022968
87AKT20.67473203
88TAOK10.66515390
89RPS6KA20.65088753
90SGK10.65052285
91MAP2K10.64564954
92YES10.64493052
93PTK2B0.64316514
94CDC42BPA0.63496592
95CDK140.63345788
96PDK10.62841486
97CLK10.61590357
98FGFR10.61379863
99MELK0.61357681
100BRSK10.60914304
101PHKG20.60678686
102PHKG10.60678686
103SGK2230.60163758
104SGK4940.60163758
105STK30.58531318
106GRK50.57964506
107PDPK10.57672321
108PRKCG0.57430111
109CDK150.56077577
110MAPK100.54818034
111FES0.54021711
112TAF10.53635416
113MAP3K100.53569916
114CDK180.53109523
115BCR0.53008917
116UHMK10.52902031
117CHEK10.52897954
118MTOR0.52817416
119JAK10.52695772
120AURKB0.51225498
121FGR0.51039855
122MAP3K60.50577442
123RPS6KA30.50169179
124EGFR0.50143497
125ERBB30.50101236
126PAK20.50017147
127MAP3K130.49819536
128LIMK10.48883611
129ROCK20.48232084
130CAMK2B0.48019802
131DAPK10.48001563
132* FYN0.47516913
133STK38L0.47357079
134CHEK20.46706065
135CDC70.46226106
136RAF10.44843857
137MET0.42966155
138BRSK20.42894292
139JAK20.42886137
140BRAF0.42607283
141* SRC0.41222398
142BUB10.40262551
143CAMK2G0.39906928
144CDK60.39653630
145EIF2AK20.39571724
146CDK10.39471139
147STK390.39124344
148PRKCE0.38939162
149CDK11A0.38487520
150ICK0.38276710
151ROCK10.36952972
152AKT30.36665009

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052162.28739983
2* Synaptic vesicle cycle_Homo sapiens_hsa047212.25463589
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01248283
4Long-term potentiation_Homo sapiens_hsa047201.96259104
5* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92211564
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.91038851
7Vitamin B6 metabolism_Homo sapiens_hsa007501.67523944
8Circadian entrainment_Homo sapiens_hsa047131.65442123
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64405451
10Olfactory transduction_Homo sapiens_hsa047401.63504980
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.63133385
12GABAergic synapse_Homo sapiens_hsa047271.61465191
13Type II diabetes mellitus_Homo sapiens_hsa049301.58910338
14Nicotine addiction_Homo sapiens_hsa050331.56648905
15Dopaminergic synapse_Homo sapiens_hsa047281.55137355
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50235735
17Amphetamine addiction_Homo sapiens_hsa050311.49521422
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49374788
19Glioma_Homo sapiens_hsa052141.48967435
20Insulin secretion_Homo sapiens_hsa049111.48180897
21Bladder cancer_Homo sapiens_hsa052191.46666161
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.44097151
23Cholinergic synapse_Homo sapiens_hsa047251.41531032
24Gastric acid secretion_Homo sapiens_hsa049711.41300875
25Salivary secretion_Homo sapiens_hsa049701.40502510
26Estrogen signaling pathway_Homo sapiens_hsa049151.40453262
27Morphine addiction_Homo sapiens_hsa050321.40340457
28Glutamatergic synapse_Homo sapiens_hsa047241.40181056
29MicroRNAs in cancer_Homo sapiens_hsa052061.38658948
30Dorso-ventral axis formation_Homo sapiens_hsa043201.37575799
31Small cell lung cancer_Homo sapiens_hsa052221.37494409
32Renin secretion_Homo sapiens_hsa049241.37179900
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33766734
34mTOR signaling pathway_Homo sapiens_hsa041501.31473355
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29306882
36Cell cycle_Homo sapiens_hsa041101.28123640
37GnRH signaling pathway_Homo sapiens_hsa049121.26207220
38Prostate cancer_Homo sapiens_hsa052151.25718447
39Nitrogen metabolism_Homo sapiens_hsa009101.23637985
40Long-term depression_Homo sapiens_hsa047301.23098336
41Oxytocin signaling pathway_Homo sapiens_hsa049211.21947798
42Gap junction_Homo sapiens_hsa045401.20333202
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20204228
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17144228
45Cocaine addiction_Homo sapiens_hsa050301.14336753
46Hippo signaling pathway_Homo sapiens_hsa043901.12955444
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.11524853
48ErbB signaling pathway_Homo sapiens_hsa040121.11327875
49Vibrio cholerae infection_Homo sapiens_hsa051101.07213989
50Endometrial cancer_Homo sapiens_hsa052131.06758965
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04794789
52Pentose phosphate pathway_Homo sapiens_hsa000301.02595615
53AMPK signaling pathway_Homo sapiens_hsa041521.02482561
54Non-homologous end-joining_Homo sapiens_hsa034501.01556506
55Biosynthesis of amino acids_Homo sapiens_hsa012300.99868296
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99298132
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99116049
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98640833
59Renal cell carcinoma_Homo sapiens_hsa052110.97740183
60N-Glycan biosynthesis_Homo sapiens_hsa005100.97696502
61Fatty acid biosynthesis_Homo sapiens_hsa000610.96444203
62Focal adhesion_Homo sapiens_hsa045100.95414496
63Axon guidance_Homo sapiens_hsa043600.95231506
64Thyroid hormone synthesis_Homo sapiens_hsa049180.94506127
65Collecting duct acid secretion_Homo sapiens_hsa049660.93682628
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93438693
67Proteoglycans in cancer_Homo sapiens_hsa052050.92767308
68Melanoma_Homo sapiens_hsa052180.92733027
69* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91826203
70Melanogenesis_Homo sapiens_hsa049160.90596505
71cAMP signaling pathway_Homo sapiens_hsa040240.90327071
72mRNA surveillance pathway_Homo sapiens_hsa030150.89696653
73TGF-beta signaling pathway_Homo sapiens_hsa043500.89661472
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.89064172
75VEGF signaling pathway_Homo sapiens_hsa043700.88324411
76Chronic myeloid leukemia_Homo sapiens_hsa052200.87767532
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86094781
78* Endocytosis_Homo sapiens_hsa041440.84918773
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84315988
80Adherens junction_Homo sapiens_hsa045200.84130510
81Amoebiasis_Homo sapiens_hsa051460.83512081
82Non-small cell lung cancer_Homo sapiens_hsa052230.81512033
83Serotonergic synapse_Homo sapiens_hsa047260.81459437
84Oocyte meiosis_Homo sapiens_hsa041140.81265040
85Taste transduction_Homo sapiens_hsa047420.81138329
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79956631
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79723342
88Acute myeloid leukemia_Homo sapiens_hsa052210.79365514
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78795948
90Colorectal cancer_Homo sapiens_hsa052100.78779125
91Lysine degradation_Homo sapiens_hsa003100.78625534
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.78590466
93RNA transport_Homo sapiens_hsa030130.78466327
94ECM-receptor interaction_Homo sapiens_hsa045120.78416543
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78383683
96Sphingolipid metabolism_Homo sapiens_hsa006000.77816462
97Viral carcinogenesis_Homo sapiens_hsa052030.77561898
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76888969
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74635253
100Dilated cardiomyopathy_Homo sapiens_hsa054140.74584737
101Insulin signaling pathway_Homo sapiens_hsa049100.74316802
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.74230186
103* Lysosome_Homo sapiens_hsa041420.74228802
104Calcium signaling pathway_Homo sapiens_hsa040200.74135721
105Pancreatic cancer_Homo sapiens_hsa052120.74040746
106Other glycan degradation_Homo sapiens_hsa005110.73985138
107HIF-1 signaling pathway_Homo sapiens_hsa040660.73905378
108Rap1 signaling pathway_Homo sapiens_hsa040150.73464557
109Carbon metabolism_Homo sapiens_hsa012000.73379787
110Inositol phosphate metabolism_Homo sapiens_hsa005620.72777414
111Prion diseases_Homo sapiens_hsa050200.71681455
112Steroid biosynthesis_Homo sapiens_hsa001000.71427615
113MAPK signaling pathway_Homo sapiens_hsa040100.71263217
114Alcoholism_Homo sapiens_hsa050340.69586094
115Prolactin signaling pathway_Homo sapiens_hsa049170.69509531
116Choline metabolism in cancer_Homo sapiens_hsa052310.69328561
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69178554
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.68857437
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68180102
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67910699
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67106667
122Tight junction_Homo sapiens_hsa045300.67063785
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66326578
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.66258065
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65277857
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65241449
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64980047
128Glucagon signaling pathway_Homo sapiens_hsa049220.64408669
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63788765
130Platelet activation_Homo sapiens_hsa046110.63741610
131Pancreatic secretion_Homo sapiens_hsa049720.63032288
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.62711939
133Pathways in cancer_Homo sapiens_hsa052000.60646287
134Type I diabetes mellitus_Homo sapiens_hsa049400.59804605
135Phagosome_Homo sapiens_hsa041450.59618029
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59588671
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59322030
138Chemokine signaling pathway_Homo sapiens_hsa040620.59309672
139Fructose and mannose metabolism_Homo sapiens_hsa000510.59079608
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58609267
141Hepatitis C_Homo sapiens_hsa051600.56363097
142Galactose metabolism_Homo sapiens_hsa000520.55465615
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55047822
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53761494
145DNA replication_Homo sapiens_hsa030300.53317577
146Hepatitis B_Homo sapiens_hsa051610.52679248

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