CLTA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.69333399
2viral transcription (GO:0019083)5.53799746
3translational termination (GO:0006415)5.35304409
4COPI coating of Golgi vesicle (GO:0048205)5.27816623
5Golgi transport vesicle coating (GO:0048200)5.27816623
6formation of translation preinitiation complex (GO:0001731)4.98717903
7translational elongation (GO:0006414)4.90791842
8protein retention in ER lumen (GO:0006621)4.73973933
9translational initiation (GO:0006413)4.59320487
10ribosomal small subunit assembly (GO:0000028)4.56380212
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.49657780
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.40980503
13nuclear envelope reassembly (GO:0031468)4.35988412
14mitotic nuclear envelope reassembly (GO:0007084)4.35988412
15Arp2/3 complex-mediated actin nucleation (GO:0034314)4.33575423
16viral life cycle (GO:0019058)4.31950143
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.30734746
18regulation of early endosome to late endosome transport (GO:2000641)4.24778836
19protein targeting to ER (GO:0045047)4.21306039
20cellular protein complex disassembly (GO:0043624)4.20446913
21cotranslational protein targeting to membrane (GO:0006613)4.16365969
22ribosomal small subunit biogenesis (GO:0042274)4.15265162
23maturation of SSU-rRNA (GO:0030490)4.14468404
24establishment of viral latency (GO:0019043)4.10120697
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.00183064
26establishment of integrated proviral latency (GO:0075713)3.99774054
27regulation of protein heterodimerization activity (GO:0043497)3.97378933
28protein localization to endosome (GO:0036010)3.95778308
29protein localization to endoplasmic reticulum (GO:0070972)3.93291248
30ribosomal large subunit biogenesis (GO:0042273)3.89586986
31regulation of translational termination (GO:0006449)3.85041992
32protein complex disassembly (GO:0043241)3.79224078
33negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.69681950
34retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.69245253
35DNA deamination (GO:0045006)3.63791120
36macromolecular complex disassembly (GO:0032984)3.60008265
37DNA unwinding involved in DNA replication (GO:0006268)3.45365269
38deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.45234969
39ribosome assembly (GO:0042255)3.44282862
40maternal placenta development (GO:0001893)3.28727365
41ribonucleoprotein complex biogenesis (GO:0022613)3.28124596
42regulation of mammary gland epithelial cell proliferation (GO:0033599)3.26925757
43folic acid-containing compound biosynthetic process (GO:0009396)3.21717559
44DNA strand elongation involved in DNA replication (GO:0006271)3.18130496
45positive regulation of SMAD protein import into nucleus (GO:0060391)3.14868264
46cellular copper ion homeostasis (GO:0006878)3.13826094
47UV protection (GO:0009650)3.12549644
48regulation of SMAD protein import into nucleus (GO:0060390)3.09104622
49translation (GO:0006412)3.08371735
50deoxyribose phosphate biosynthetic process (GO:0046385)3.06837005
512-deoxyribonucleotide biosynthetic process (GO:0009265)3.06837005
52pentose-phosphate shunt (GO:0006098)3.06713279
53actin nucleation (GO:0045010)3.05742183
54mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.03828514
55protein targeting to membrane (GO:0006612)3.02336645
56T cell apoptotic process (GO:0070231)3.01305950
57glycosphingolipid catabolic process (GO:0046479)2.99985133
58negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99963171
59regulation of translational fidelity (GO:0006450)2.99500383
60nuclear-transcribed mRNA catabolic process (GO:0000956)2.93731066
61pinocytosis (GO:0006907)2.93586461
62barbed-end actin filament capping (GO:0051016)2.90259315
63DNA strand elongation (GO:0022616)2.89278038
64regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.88958566
65glucose catabolic process (GO:0006007)2.87814551
66ncRNA 3-end processing (GO:0043628)2.86177228
67ribosome biogenesis (GO:0042254)2.86175322
68GDP-mannose metabolic process (GO:0019673)2.85058186
69apoptotic cell clearance (GO:0043277)2.83564933
70proline biosynthetic process (GO:0006561)2.82650627
71positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.81030587
72peptidyl-arginine omega-N-methylation (GO:0035247)2.80943323
73skin morphogenesis (GO:0043589)2.79317289
74histone arginine methylation (GO:0034969)2.78809813
75positive regulation of lamellipodium assembly (GO:0010592)2.78597722
76heterochromatin organization (GO:0070828)2.76173591
77endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.75536760
78mRNA catabolic process (GO:0006402)2.73991909
79glycolipid catabolic process (GO:0019377)2.72797283
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.72531293
81mitotic G1 DNA damage checkpoint (GO:0031571)2.72223109
82nucleobase-containing small molecule interconversion (GO:0015949)2.70872655
83antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.70711747
84deoxyribonucleotide biosynthetic process (GO:0009263)2.70111175
85chaperone mediated protein folding requiring cofactor (GO:0051085)2.70080590
86folic acid metabolic process (GO:0046655)2.69464381
87RNA catabolic process (GO:0006401)2.69172165
88DNA replication initiation (GO:0006270)2.69081411
89peptidyl-proline hydroxylation (GO:0019511)2.68910932
90telomere maintenance via semi-conservative replication (GO:0032201)2.67414609
91NADPH regeneration (GO:0006740)2.66947955
92regulation of posttranscriptional gene silencing (GO:0060147)2.66551829
93regulation of gene silencing by miRNA (GO:0060964)2.66551829
94regulation of gene silencing by RNA (GO:0060966)2.66551829
95adhesion of symbiont to host cell (GO:0044650)2.65569555
96virion attachment to host cell (GO:0019062)2.65569555
97pentose metabolic process (GO:0019321)2.65252354
98protein localization to kinetochore (GO:0034501)2.65100133
99positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.64751286
100nucleobase biosynthetic process (GO:0046112)2.64718051
101cellular response to arsenic-containing substance (GO:0071243)2.64248452
102cyclooxygenase pathway (GO:0019371)2.63706773
103mitochondrial fusion (GO:0008053)2.63660371
104modulation by symbiont of host immune response (GO:0052553)2.62547018
105positive regulation by symbiont of host defense response (GO:0052509)2.62547018
106modulation by symbiont of host defense response (GO:0052031)2.62547018
107modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62547018
108modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62547018
109positive regulation by organism of defense response of other organism involved in symbiotic interact2.62547018
110hyaluronan catabolic process (GO:0030214)2.62013085
111antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.60760034
112protein insertion into membrane (GO:0051205)2.60474880
113regulation of interferon-beta biosynthetic process (GO:0045357)2.58466913
114activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.55868379
115adhesion of symbiont to host (GO:0044406)2.55760174
116spliceosomal tri-snRNP complex assembly (GO:0000244)2.55606304
117lymphocyte apoptotic process (GO:0070227)2.55371702
118anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55294578
119positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54668772
120cell adhesion mediated by integrin (GO:0033627)2.54567866
121regulation of superoxide anion generation (GO:0032928)2.53386190
122purine nucleobase biosynthetic process (GO:0009113)2.52474657
123de novo protein folding (GO:0006458)2.52451743
124interferon-gamma secretion (GO:0072643)2.52214279
125sequestering of actin monomers (GO:0042989)2.51062887
126regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.50759514
127immunoglobulin mediated immune response (GO:0016064)2.50676167
128amino sugar catabolic process (GO:0046348)2.50316284
129negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49603781
130negative regulation of ligase activity (GO:0051352)2.49603781
131epithelial cell-cell adhesion (GO:0090136)2.49365975
132rRNA processing (GO:0006364)2.49363452
133embryo implantation (GO:0007566)2.48453674
134glucose 6-phosphate metabolic process (GO:0051156)2.48125291
135regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47457551
136negative regulation of cell size (GO:0045792)2.46506042
137prostanoid biosynthetic process (GO:0046457)2.46479732
138prostaglandin biosynthetic process (GO:0001516)2.46479732
139extracellular fibril organization (GO:0043206)2.46457614
140DNA replication-dependent nucleosome organization (GO:0034723)2.45763425
141DNA replication-dependent nucleosome assembly (GO:0006335)2.45763425
142negative regulation of RNA splicing (GO:0033119)2.45731135
143morphogenesis of an endothelium (GO:0003159)2.45565821
144endothelial tube morphogenesis (GO:0061154)2.45565821
145protein hydroxylation (GO:0018126)2.45471422
146regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.45175149
147mitotic nuclear envelope disassembly (GO:0007077)2.43047995
148B cell mediated immunity (GO:0019724)2.42211577
149positive regulation of lamellipodium organization (GO:1902745)2.41859717
150dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.41851061
151mitochondrial calcium ion transport (GO:0006851)2.41815128
152glial cell migration (GO:0008347)2.41460406
153virion assembly (GO:0019068)2.37982232
154de novo posttranslational protein folding (GO:0051084)2.37379377
155lipopolysaccharide biosynthetic process (GO:0009103)2.37186291
156positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.36891447
157rRNA metabolic process (GO:0016072)2.36886836
158spliceosomal snRNP assembly (GO:0000387)2.36542940
159negative regulation of mitochondrion organization (GO:0010823)2.36516454
160peptidyl-arginine N-methylation (GO:0035246)2.36395128
161peptidyl-arginine methylation (GO:0018216)2.36395128
162regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.35351347
163oligosaccharide catabolic process (GO:0009313)2.34968809
164mitotic chromosome condensation (GO:0007076)2.32647872
165pyrimidine-containing compound salvage (GO:0008655)2.32438530
166pyrimidine nucleoside salvage (GO:0043097)2.32438530
167guanosine-containing compound biosynthetic process (GO:1901070)2.32293493
168endodermal cell differentiation (GO:0035987)2.32280838
169regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.31716297
170transferrin transport (GO:0033572)2.31602156
171stress fiber assembly (GO:0043149)2.30311063
172protein complex localization (GO:0031503)2.29370312
173basement membrane organization (GO:0071711)2.29039911
174natural killer cell mediated cytotoxicity (GO:0042267)2.27654107
175natural killer cell mediated immunity (GO:0002228)2.27654107
176ceramide catabolic process (GO:0046514)2.26362122
177activation of MAPKKK activity (GO:0000185)2.24756523
178pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.21234187
179polyamine biosynthetic process (GO:0006596)2.21015496
180positive regulation of nuclease activity (GO:0032075)2.20644628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.49282633
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.04052838
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.36187118
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.17808741
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.57715450
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56082586
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55137140
8MYC_22102868_ChIP-Seq_BL_Human2.46847959
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17205984
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14725216
11VDR_21846776_ChIP-Seq_THP-1_Human2.14182775
12XRN2_22483619_ChIP-Seq_HELA_Human2.12978309
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10690361
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.06411530
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02364070
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.96574230
17ZNF263_19887448_ChIP-Seq_K562_Human1.80512944
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79733664
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78361426
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77519794
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.72189299
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71384632
23* GABP_17652178_ChIP-ChIP_JURKAT_Human1.69592782
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69288414
25KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.68786854
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67601652
27TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65902655
28* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64219871
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63541196
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59005527
31* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58683005
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.58253688
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.56676843
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55544139
35* TFEB_21752829_ChIP-Seq_HELA_Human1.55194226
36DCP1A_22483619_ChIP-Seq_HELA_Human1.53811215
37TTF2_22483619_ChIP-Seq_HELA_Human1.48880245
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48548109
39GABP_19822575_ChIP-Seq_HepG2_Human1.48199482
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46871916
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46439968
42LXR_22292898_ChIP-Seq_THP-1_Human1.46127250
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45399175
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44216608
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43061681
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41409272
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39412166
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39002396
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37866814
50CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.36768413
51CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35293123
52* VDR_23849224_ChIP-Seq_CD4+_Human1.34306074
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34155741
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33610946
55SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.31979560
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.31850835
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31788223
58ATF3_27146783_Chip-Seq_COLON_Human1.31509908
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.30454341
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30058965
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29712013
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28708890
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28680342
64CIITA_25753668_ChIP-Seq_RAJI_Human1.27915952
65OCT4_18692474_ChIP-Seq_MEFs_Mouse1.26968991
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26677429
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26087209
68SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24776527
69* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24149331
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.22785228
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22725679
72KDM2B_26808549_Chip-Seq_DND41_Human1.22463915
73TP53_22127205_ChIP-Seq_IMR90_Human1.21362188
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21329326
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21321830
76* P68_20966046_ChIP-Seq_HELA_Human1.21221906
77* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21077914
78* SPI1_23547873_ChIP-Seq_NB4_Human1.21038484
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19784482
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19513468
81TCF7_22412390_ChIP-Seq_EML_Mouse1.19439975
82MAF_26560356_Chip-Seq_TH1_Human1.19263576
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19061036
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18414115
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17675224
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.16409369
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16240185
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.15511402
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15487868
90RACK7_27058665_Chip-Seq_MCF-7_Human1.15355429
91VDR_24763502_ChIP-Seq_THP-1_Human1.14930483
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14614508
93KDM5A_27292631_Chip-Seq_BREAST_Human1.14574185
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.14498739
95* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14026401
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13965697
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13726485
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.13675245
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12018946
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.11656668
101CLOCK_20551151_ChIP-Seq_293T_Human1.11621337
102ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11381814
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.10688543
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10446653
105AR_21909140_ChIP-Seq_LNCAP_Human1.09084797
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09035750
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08899809
108* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08899475
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08760937
110UTX_26944678_Chip-Seq_JUKART_Human1.08725514
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08259451
112* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07063569
113P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06931238
114ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05372588
115* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.05182262
116SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05032143
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04409967
118SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04118886
119SA1_27219007_Chip-Seq_ERYTHROID_Human1.04077606
120PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03418002
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02934833
122FOXP3_21729870_ChIP-Seq_TREG_Human1.00596740
123TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00251998
124RUNX1_22412390_ChIP-Seq_EML_Mouse1.00058472
125THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00055281
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99045915
127MAF_26560356_Chip-Seq_TH2_Human0.98198859
128E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98187386
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97829445
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97235368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.37046409
2MP0003705_abnormal_hypodermis_morpholog3.84437409
3MP0003303_peritoneal_inflammation3.57534524
4MP0003693_abnormal_embryo_hatching3.48419643
5MP0009840_abnormal_foam_cell3.25886389
6MP0010352_gastrointestinal_tract_polyps3.21968128
7MP0005058_abnormal_lysosome_morphology3.18721304
8MP0004957_abnormal_blastocyst_morpholog2.92997936
9MP0005451_abnormal_body_composition2.70620686
10MP0008260_abnormal_autophagy2.60946119
11MP0003806_abnormal_nucleotide_metabolis2.56100811
12MP0010234_abnormal_vibrissa_follicle2.44517641
13MP0003329_amyloid_beta_deposits2.44083742
14MP0003111_abnormal_nucleus_morphology2.37340925
15MP0010030_abnormal_orbit_morphology2.36208530
16MP0003436_decreased_susceptibility_to2.34420868
17MP0004272_abnormal_basement_membrane2.32640327
18MP0003172_abnormal_lysosome_physiology2.26868970
19MP0010307_abnormal_tumor_latency2.24702621
20MP0005076_abnormal_cell_differentiation2.23492753
21MP0003566_abnormal_cell_adhesion2.16861736
22MP0003186_abnormal_redox_activity2.12974221
23MP0008438_abnormal_cutaneous_collagen2.12376739
24MP0003077_abnormal_cell_cycle2.10672418
25MP0009379_abnormal_foot_pigmentation1.99131140
26MP0009333_abnormal_splenocyte_physiolog1.88319991
27MP0000858_altered_metastatic_potential1.82166558
28MP0001730_embryonic_growth_arrest1.80446558
29MP0001542_abnormal_bone_strength1.77750952
30MP0000490_abnormal_crypts_of1.72594569
31MP0005501_abnormal_skin_physiology1.71329698
32MP0003123_paternal_imprinting1.69729541
33MP0005023_abnormal_wound_healing1.67274712
34MP0003453_abnormal_keratinocyte_physiol1.65897540
35MP0008007_abnormal_cellular_replicative1.59208405
36MP0001849_ear_inflammation1.58656146
37MP0000350_abnormal_cell_proliferation1.58506815
38MP0004185_abnormal_adipocyte_glucose1.58121709
39MP0009278_abnormal_bone_marrow1.57650024
40MP0003191_abnormal_cellular_cholesterol1.53895515
41MP0005165_increased_susceptibility_to1.53569061
42MP0006082_CNS_inflammation1.47014913
43MP0004233_abnormal_muscle_weight1.46510320
44MP0008932_abnormal_embryonic_tissue1.42252252
45MP0003448_altered_tumor_morphology1.41851572
46MP0001835_abnormal_antigen_presentation1.41338494
47MP0003300_gastrointestinal_ulcer1.36399644
48MP0001243_abnormal_dermal_layer1.35925316
49MP0002796_impaired_skin_barrier1.33078619
50MP0002452_abnormal_antigen_presenting1.32185808
51MP0004858_abnormal_nervous_system1.31748226
52MP0003634_abnormal_glial_cell1.31254278
53MP0010094_abnormal_chromosome_stability1.31142016
54MP0000358_abnormal_cell_content/1.30152263
55MP0002080_prenatal_lethality1.29846885
56MP0005397_hematopoietic_system_phenotyp1.28300759
57MP0001545_abnormal_hematopoietic_system1.28300759
58MP0001727_abnormal_embryo_implantation1.27082140
59MP0003941_abnormal_skin_development1.26678350
60MP0005000_abnormal_immune_tolerance1.24965113
61MP0001697_abnormal_embryo_size1.24005169
62MP0000537_abnormal_urethra_morphology1.23726848
63MP0002060_abnormal_skin_morphology1.22291488
64MP0002419_abnormal_innate_immunity1.21500987
65MP0004808_abnormal_hematopoietic_stem1.21207652
66MP0010368_abnormal_lymphatic_system1.19507265
67MP0001533_abnormal_skeleton_physiology1.18968293
68MP0006054_spinal_hemorrhage1.18664454
69MP0002019_abnormal_tumor_incidence1.16864558
70MP0000685_abnormal_immune_system1.16749954
71MP0002396_abnormal_hematopoietic_system1.16376456
72MP0002722_abnormal_immune_system1.13767074
73MP0002086_abnormal_extraembryonic_tissu1.13672780
74MP0005257_abnormal_intraocular_pressure1.13143126
75MP0005197_abnormal_uvea_morphology1.11818710
76MP0000689_abnormal_spleen_morphology1.10890641
77MP0000313_abnormal_cell_death1.08958993
78MP0002398_abnormal_bone_marrow1.08826424
79MP0001819_abnormal_immune_cell1.07657709
80MP0002405_respiratory_system_inflammati1.07514898
81MP0002420_abnormal_adaptive_immunity1.06840359
82MP0009053_abnormal_anal_canal1.04913607
83MP0005464_abnormal_platelet_physiology1.04274843
84MP0003075_altered_response_to1.02407221
85MP0000604_amyloidosis1.01708235
86MP0001958_emphysema1.00991369
87MP0003283_abnormal_digestive_organ1.00546459
88MP0002429_abnormal_blood_cell1.00513715
89MP0003091_abnormal_cell_migration1.00491284
90MP0005025_abnormal_response_to1.00145408
91MP0003221_abnormal_cardiomyocyte_apopto0.99390893
92MP0001800_abnormal_humoral_immune0.99319485
93MP0002084_abnormal_developmental_patter0.99133051
94MP0008770_decreased_survivor_rate0.98280988
95MP0000716_abnormal_immune_system0.96906908
96MP0005380_embryogenesis_phenotype0.96903908
97MP0001672_abnormal_embryogenesis/_devel0.96903908
98MP0000343_altered_response_to0.96622601
99MP0000747_muscle_weakness0.96384443
100MP0000681_abnormal_thyroid_gland0.95729354
101MP0004947_skin_inflammation0.95429871
102MP0002085_abnormal_embryonic_tissue0.95065849
103MP0002723_abnormal_immune_serum0.95059966
104MP0001853_heart_inflammation0.94525943
105MP0005621_abnormal_cell_physiology0.92362868
106MP0000465_gastrointestinal_hemorrhage0.92319040
107MP0004197_abnormal_fetal_growth/weight/0.91737813
108MP0005193_abnormal_anterior_eye0.91733614
109MP0001915_intracranial_hemorrhage0.91354521
110MP0002088_abnormal_embryonic_growth/wei0.91339811
111MP0003984_embryonic_growth_retardation0.90633648
112MP0005508_abnormal_skeleton_morphology0.89748010
113MP0003315_abnormal_perineum_morphology0.89387158
114MP0000477_abnormal_intestine_morphology0.88011931
115MP0002148_abnormal_hypersensitivity_rea0.87561740
116MP0005384_cellular_phenotype0.87560496
117MP0002896_abnormal_bone_mineralization0.87395233
118MP0000762_abnormal_tongue_morphology0.85786488
119MP0000733_abnormal_muscle_development0.85636581
120MP0001845_abnormal_inflammatory_respons0.84915045
121MP0000703_abnormal_thymus_morphology0.84337388
122MP0001881_abnormal_mammary_gland0.84323203
123MP0005166_decreased_susceptibility_to0.83855460
124MP0003119_abnormal_digestive_system0.83636743
125MP0005623_abnormal_meninges_morphology0.83493349
126MP0001216_abnormal_epidermal_layer0.82564472
127MP0002254_reproductive_system_inflammat0.81668186
128MP0010771_integument_phenotype0.80735803
129MP0001348_abnormal_lacrimal_gland0.80083640
130MP0002998_abnormal_bone_remodeling0.79386364
131MP0005275_abnormal_skin_tensile0.79292527
132MP0004510_myositis0.78105218
133MP0000678_abnormal_parathyroid_gland0.77696919
134MP0000462_abnormal_digestive_system0.75846880
135MP0003279_aneurysm0.75703809
136MP0004859_abnormal_synaptic_plasticity0.75529119
137MP0000750_abnormal_muscle_regeneration0.74898351
138MP0002135_abnormal_kidney_morphology0.74473331
139MP0005595_abnormal_vascular_smooth0.72376865
140MP0004883_abnormal_blood_vessel0.70981710
141MP0002089_abnormal_postnatal_growth/wei0.70976143
142MP0003385_abnormal_body_wall0.69641530
143MP0000013_abnormal_adipose_tissue0.67880118
144MP0000003_abnormal_adipose_tissue0.66152910
145MP0001299_abnormal_eye_distance/0.62147823
146MP0002092_abnormal_eye_morphology0.61618132

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)3.80689348
2Increased cerebral lipofuscin (HP:0011813)3.67124773
3Cerebral aneurysm (HP:0004944)3.29670428
4Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.27791680
5Protrusio acetabuli (HP:0003179)3.25971335
6Neurofibrillary tangles (HP:0002185)3.24866689
7Nuclear cataract (HP:0100018)3.19299165
8Abnormal number of erythroid precursors (HP:0012131)3.17161245
9Dysostosis multiplex (HP:0000943)3.14591963
10Short nail (HP:0001799)3.11993167
11Multiple enchondromatosis (HP:0005701)3.01852978
12Diminished motivation (HP:0000745)2.99702371
13Insomnia (HP:0100785)2.96483568
14Increased neuronal autofluorescent lipopigment (HP:0002074)2.92403109
15Reticulocytopenia (HP:0001896)2.92384219
16Agnosia (HP:0010524)2.91503597
17Vacuolated lymphocytes (HP:0001922)2.90163982
18Cerebral inclusion bodies (HP:0100314)2.86343235
19Trismus (HP:0000211)2.82346950
20Abnormality of glycolipid metabolism (HP:0010969)2.81017230
21Abnormality of liposaccharide metabolism (HP:0010968)2.81017230
22Abnormality of glycosphingolipid metabolism (HP:0004343)2.81017230
23Hand muscle atrophy (HP:0009130)2.79435109
24Cervical subluxation (HP:0003308)2.77335462
25Personality changes (HP:0000751)2.76763172
26Apathy (HP:0000741)2.70202913
27Spinal muscular atrophy (HP:0007269)2.63277104
28Achilles tendon contracture (HP:0001771)2.63127985
29Recurrent abscess formation (HP:0002722)2.61599269
30Genu recurvatum (HP:0002816)2.61578221
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.61563515
32Upper motor neuron abnormality (HP:0002127)2.61266496
33Systemic lupus erythematosus (HP:0002725)2.60767160
34Disinhibition (HP:0000734)2.58489594
35Urinary glycosaminoglycan excretion (HP:0003541)2.58293641
36Mucopolysacchariduria (HP:0008155)2.58293641
37Eczematoid dermatitis (HP:0000976)2.56595265
38Abnormality of dentin (HP:0010299)2.56319411
39Abnormality of the anterior horn cell (HP:0006802)2.55289334
40Degeneration of anterior horn cells (HP:0002398)2.55289334
41Abnormality of macrophages (HP:0004311)2.49572117
42Abnormality of the motor neurons (HP:0002450)2.48778054
43Abnormal neuron morphology (HP:0012757)2.48778054
44Microretrognathia (HP:0000308)2.48283162
45Vertebral compression fractures (HP:0002953)2.46098048
46Overriding aorta (HP:0002623)2.40819018
47Difficulty climbing stairs (HP:0003551)2.39623834
48Upper limb muscle weakness (HP:0003484)2.35808783
49Pallor (HP:0000980)2.34821597
50Tetraparesis (HP:0002273)2.34518332
51Osteolytic defects of the hand bones (HP:0009699)2.34000683
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.34000683
53Interstitial pulmonary disease (HP:0006530)2.33859348
54Upper limb amyotrophy (HP:0009129)2.33476260
55Distal upper limb amyotrophy (HP:0007149)2.33476260
56Premature rupture of membranes (HP:0001788)2.31962932
57Abnormality of the Achilles tendon (HP:0005109)2.30709697
58Thrombocytosis (HP:0001894)2.30389115
59Hyperparathyroidism (HP:0000843)2.29222435
60Macrocytic anemia (HP:0001972)2.28722580
61Supranuclear gaze palsy (HP:0000605)2.28266953
62Selective tooth agenesis (HP:0001592)2.28263409
63Broad distal phalanx of finger (HP:0009836)2.27735501
64Abnormality of polysaccharide metabolism (HP:0011012)2.27527526
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27527526
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27527526
67Atrophic scars (HP:0001075)2.24636272
68Angiofibromas (HP:0010615)2.22302469
69Adenoma sebaceum (HP:0009720)2.22302469
70Cellulitis (HP:0100658)2.21793385
71Elbow flexion contracture (HP:0002987)2.21574850
72Fragile skin (HP:0001030)2.20940851
73Natal tooth (HP:0000695)2.20689218
74Progressive neurologic deterioration (HP:0002344)2.19388656
75Poor head control (HP:0002421)2.19200651
76Axonal loss (HP:0003447)2.18893127
77Bladder diverticulum (HP:0000015)2.17980309
78Atrophy/Degeneration involving motor neurons (HP:0007373)2.17015783
79Entropion (HP:0000621)2.16529172
80Neuronal loss in central nervous system (HP:0002529)2.16263844
81Recurrent bacterial skin infections (HP:0005406)2.15700914
82Prolonged neonatal jaundice (HP:0006579)2.15127737
83Distal lower limb amyotrophy (HP:0008944)2.13270543
84Ragged-red muscle fibers (HP:0003200)2.11953623
85Spinal rigidity (HP:0003306)2.08996389
86Ankle contracture (HP:0006466)2.08184252
87Distal lower limb muscle weakness (HP:0009053)2.08147640
88Shallow orbits (HP:0000586)2.07924406
89Hypokinesia (HP:0002375)2.05492919
90Slender long bone (HP:0003100)2.03021737
91Limb-girdle muscle atrophy (HP:0003797)2.02726496
92Peritonitis (HP:0002586)2.02237760
93Abnormality of the nasal mucosa (HP:0000433)2.02088561
94Renal duplication (HP:0000075)2.00256504
95Hyperacusis (HP:0010780)2.00217918
96Back pain (HP:0003418)1.99615885
97Fasciculations (HP:0002380)1.98387408
98Microvesicular hepatic steatosis (HP:0001414)1.98374633
99Elevated erythrocyte sedimentation rate (HP:0003565)1.96760317
100Elfin facies (HP:0004428)1.96480366
101Abnormal trabecular bone morphology (HP:0100671)1.94265404
102Cortical dysplasia (HP:0002539)1.92453375
103Spinal cord compression (HP:0002176)1.91763982
104Abnormality of the lower motor neuron (HP:0002366)1.89744496
105Global brain atrophy (HP:0002283)1.89643419
106Mutism (HP:0002300)1.89140062
107Hematochezia (HP:0002573)1.88623985
108Colon cancer (HP:0003003)1.88547176
109Spastic diplegia (HP:0001264)1.88408206
110Pelvic girdle muscle weakness (HP:0003749)1.87254379
111Shoulder girdle muscle weakness (HP:0003547)1.86875379
112Dilatation of the ascending aorta (HP:0005111)1.85700832
113Ulnar bowing (HP:0003031)1.84465790
114Ependymoma (HP:0002888)1.83934237
115Cholecystitis (HP:0001082)1.83633231
116Abnormal gallbladder physiology (HP:0012438)1.83633231
117Increased density of long bones (HP:0006392)1.82697578
118Rough bone trabeculation (HP:0100670)1.82214293
119Wormian bones (HP:0002645)1.81760937
120Hypercortisolism (HP:0001578)1.80343892
121Multiple lipomas (HP:0001012)1.77542134
122Mesangial abnormality (HP:0001966)1.76355093
123Abnormality of the distal phalanges of the toes (HP:0010182)1.75589587
124Pustule (HP:0200039)1.75105611
125Zonular cataract (HP:0010920)1.74808479
126Carpal bone hypoplasia (HP:0001498)1.74643522
127Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71564751
128Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71564751
129Basal cell carcinoma (HP:0002671)1.70156506
130Basal ganglia calcification (HP:0002135)1.69771919
131Lower limb amyotrophy (HP:0007210)1.69496051
132Abnormality of the umbilical cord (HP:0010881)1.68969931
133Amyloidosis (HP:0011034)1.68914601
134Bicuspid aortic valve (HP:0001647)1.68552167
135Joint stiffness (HP:0001387)1.68494743
136Hypercalcemia (HP:0003072)1.68347818
137Severe short stature (HP:0003510)1.67668371
138Blue sclerae (HP:0000592)1.67448766
139Petechiae (HP:0000967)1.66875379
140Neoplasm of the pancreas (HP:0002894)1.65254726
141Hepatosplenomegaly (HP:0001433)1.65250668
142Glossoptosis (HP:0000162)1.64767538
143Increased connective tissue (HP:0009025)1.64544173
144Enlarged penis (HP:0000040)1.64467168
145Radial bowing (HP:0002986)1.63839143
146Glomerulonephritis (HP:0000099)1.63474223
147Neoplasm of head and neck (HP:0012288)1.63432957
148Abnormality of reticulocytes (HP:0004312)1.62569851
149Autoimmune thrombocytopenia (HP:0001973)1.60692954
150Gastrointestinal carcinoma (HP:0002672)1.58872440
151Malignant gastrointestinal tract tumors (HP:0006749)1.58872440
152Loss of speech (HP:0002371)1.58503007
153Cutaneous melanoma (HP:0012056)1.57808084
154Increased serum ferritin (HP:0003281)1.55331640
155Abnormality of the vasculature of the conjunctiva (HP:0008054)1.55115491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL23.35029200
2TRIB33.30177186
3NME23.13915889
4PKN22.96991511
5BUB12.87221129
6IRAK32.85246719
7PBK2.69230499
8MAP3K102.62074382
9ERN12.52171899
10TESK22.45201926
11VRK22.30181990
12SMG12.24698276
13BLK2.22708507
14PAK42.11389809
15MAP3K112.06770821
16EEF2K2.05632582
17WEE11.95086400
18LRRK21.91522676
19EPHA21.88993308
20ARAF1.84909417
21MAP3K91.80129359
22TESK11.75739960
23NEK21.75410856
24NEK11.70403809
25RPS6KA41.62842066
26PIM21.56290571
27GRK61.51129701
28KSR21.49649074
29MAP4K11.47104713
30MAPKAPK31.43390989
31RPS6KB21.41906507
32MAP3K81.39442736
33EPHB21.37808605
34ICK1.32223460
35ZAP701.29754027
36STK101.23337942
37KDR1.23244349
38ALK1.15495967
39CDC71.14278033
40MST1R1.14056430
41LATS21.13084452
42EIF2AK11.11876077
43MAP2K31.06917697
44LIMK11.06363334
45MAP2K21.03267328
46ILK1.01540571
47ERBB41.00202580
48TLK10.98146115
49BMX0.97732167
50DYRK30.96974935
51PTK60.95751493
52LMTK20.94673482
53RIPK10.93128838
54MAP3K120.92861129
55BCKDK0.92650395
56TBK10.91543069
57MOS0.90510684
58AURKA0.89740280
59PRKG20.89255534
60PRPF4B0.87737795
61TYK20.86810249
62CDK190.85545981
63TGFBR20.84656897
64PAK10.83646460
65MAP2K70.83422109
66MET0.82446949
67CDK180.82079921
68TAOK10.81996516
69SRPK10.81118627
70RIPK40.79585489
71MATK0.79344362
72TGFBR10.78899375
73CDK120.75914456
74BRAF0.74402151
75DAPK30.73261273
76CAMKK10.71679480
77PLK10.70471632
78TTK0.70021862
79TSSK60.67395834
80CAMK2G0.64693043
81ABL20.64665297
82SIK20.63823711
83CSF1R0.63672486
84MYLK0.63364532
85PTK20.62428577
86CDK40.61747235
87PIM10.60664199
88MINK10.58238646
89AURKB0.57102868
90PAK20.56702918
91CDK70.56410271
92CHEK20.56030388
93RAF10.54530708
94MARK30.53971525
95CDK60.53540700
96KSR10.52924423
97PRKCI0.52633023
98SYK0.51544397
99CDK140.51120642
100STK160.50534389
101FLT30.50330997
102DAPK10.50232379
103PDGFRA0.49353971
104CDK90.48935428
105RPS6KA20.48142884
106CSNK1G30.48104498
107PASK0.45657366
108FES0.44726343
109ROCK20.43031864
110EIF2AK30.42720211
111TTN0.42702553
112AKT20.42692118
113SIK10.39841266
114MAP3K10.39284916
115TAOK20.39059286
116NTRK10.38469977
117BRSK10.38425887
118CDK11A0.38238735
119MAP2K10.38094246
120MAP3K50.37956810
121DDR20.37845177
122PAK60.36647148
123HCK0.36617939
124MAP3K30.36569793
125CAMKK20.36166861
126CDK150.34974994
127BTK0.34724160
128EPHB10.33285447
129EGFR0.32405291
130MTOR0.32181681
131PRKD30.32131594
132CAMK2B0.30980860
133PDK20.30261514
134TIE10.29618231
135PRKD20.29501549
136CSNK1A1L0.28232578
137VRK10.27877431

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.08465280
2DNA replication_Homo sapiens_hsa030303.14054769
3Proteasome_Homo sapiens_hsa030503.11726695
4Spliceosome_Homo sapiens_hsa030402.21161309
5Mismatch repair_Homo sapiens_hsa034302.17093768
6RNA transport_Homo sapiens_hsa030132.02229592
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97533252
8Base excision repair_Homo sapiens_hsa034101.91828618
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.90802854
10* Lysosome_Homo sapiens_hsa041421.88155856
11Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.86186822
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.83237699
13Glutathione metabolism_Homo sapiens_hsa004801.82780428
14Shigellosis_Homo sapiens_hsa051311.70899060
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63723002
16Antigen processing and presentation_Homo sapiens_hsa046121.62901750
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54847293
18Carbon metabolism_Homo sapiens_hsa012001.54115742
19Other glycan degradation_Homo sapiens_hsa005111.53988835
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51236215
21Sulfur relay system_Homo sapiens_hsa041221.47730073
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46784092
23Leishmaniasis_Homo sapiens_hsa051401.45872322
24* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45851777
25Oxidative phosphorylation_Homo sapiens_hsa001901.44076478
26Apoptosis_Homo sapiens_hsa042101.35409904
27Pyrimidine metabolism_Homo sapiens_hsa002401.34324291
28Chronic myeloid leukemia_Homo sapiens_hsa052201.33809649
29Cell cycle_Homo sapiens_hsa041101.32181324
30Legionellosis_Homo sapiens_hsa051341.30659171
31Fatty acid elongation_Homo sapiens_hsa000621.28959840
32Thyroid cancer_Homo sapiens_hsa052161.24853800
33Epstein-Barr virus infection_Homo sapiens_hsa051691.23827029
34p53 signaling pathway_Homo sapiens_hsa041151.23368762
35RNA polymerase_Homo sapiens_hsa030201.21777892
36Nucleotide excision repair_Homo sapiens_hsa034201.21052647
37Bladder cancer_Homo sapiens_hsa052191.20638043
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18976597
39Salmonella infection_Homo sapiens_hsa051321.18406350
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15452441
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14589897
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13892881
43Tuberculosis_Homo sapiens_hsa051521.13831008
44One carbon pool by folate_Homo sapiens_hsa006701.13220588
45B cell receptor signaling pathway_Homo sapiens_hsa046621.12597721
46Huntingtons disease_Homo sapiens_hsa050161.10887819
47Parkinsons disease_Homo sapiens_hsa050121.10196516
48Osteoclast differentiation_Homo sapiens_hsa043801.09927498
49Galactose metabolism_Homo sapiens_hsa000521.07956904
50Rheumatoid arthritis_Homo sapiens_hsa053231.07514572
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.07263790
52Sulfur metabolism_Homo sapiens_hsa009201.06403633
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04074303
54Phagosome_Homo sapiens_hsa041451.04017703
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03499254
56Pertussis_Homo sapiens_hsa051331.02916310
57Viral carcinogenesis_Homo sapiens_hsa052030.98961712
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98708388
59VEGF signaling pathway_Homo sapiens_hsa043700.98232596
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94272618
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94068691
62Colorectal cancer_Homo sapiens_hsa052100.93227009
63* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92195518
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.89460299
65Pentose phosphate pathway_Homo sapiens_hsa000300.89347556
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88045500
67Phenylalanine metabolism_Homo sapiens_hsa003600.87985962
68HIF-1 signaling pathway_Homo sapiens_hsa040660.84688798
69mTOR signaling pathway_Homo sapiens_hsa041500.83978745
70Alzheimers disease_Homo sapiens_hsa050100.83978080
71Acute myeloid leukemia_Homo sapiens_hsa052210.82360450
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81816171
73HTLV-I infection_Homo sapiens_hsa051660.80625064
74* Endocytosis_Homo sapiens_hsa041440.79404445
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78490504
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.78416619
77Prion diseases_Homo sapiens_hsa050200.77487777
78Non-small cell lung cancer_Homo sapiens_hsa052230.77126221
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77062224
80Vibrio cholerae infection_Homo sapiens_hsa051100.76986524
81Hepatitis B_Homo sapiens_hsa051610.76526252
82Alcoholism_Homo sapiens_hsa050340.75785419
83Proteoglycans in cancer_Homo sapiens_hsa052050.74834403
84Systemic lupus erythematosus_Homo sapiens_hsa053220.74552598
85Glioma_Homo sapiens_hsa052140.73973392
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.73364771
87Renin-angiotensin system_Homo sapiens_hsa046140.73168553
88Toxoplasmosis_Homo sapiens_hsa051450.70991596
89Vitamin B6 metabolism_Homo sapiens_hsa007500.70859698
90Small cell lung cancer_Homo sapiens_hsa052220.69268569
91Oocyte meiosis_Homo sapiens_hsa041140.66737150
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.65537894
93Pancreatic cancer_Homo sapiens_hsa052120.65024661
94Fructose and mannose metabolism_Homo sapiens_hsa000510.64912175
95N-Glycan biosynthesis_Homo sapiens_hsa005100.63268783
96mRNA surveillance pathway_Homo sapiens_hsa030150.63017734
97Herpes simplex infection_Homo sapiens_hsa051680.60231526
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60087501
99Folate biosynthesis_Homo sapiens_hsa007900.59940683
100Staphylococcus aureus infection_Homo sapiens_hsa051500.59686052
101Pyruvate metabolism_Homo sapiens_hsa006200.59224857
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58552882
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57062710
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55891517
105* Synaptic vesicle cycle_Homo sapiens_hsa047210.55067599
106Hippo signaling pathway_Homo sapiens_hsa043900.53777822
107Collecting duct acid secretion_Homo sapiens_hsa049660.53692276
108MicroRNAs in cancer_Homo sapiens_hsa052060.51835871
109Amoebiasis_Homo sapiens_hsa051460.51661697
110Influenza A_Homo sapiens_hsa051640.50852425
111Viral myocarditis_Homo sapiens_hsa054160.50007480
112Endometrial cancer_Homo sapiens_hsa052130.49229053
113Focal adhesion_Homo sapiens_hsa045100.49073475
114Renal cell carcinoma_Homo sapiens_hsa052110.48550578
115Arginine and proline metabolism_Homo sapiens_hsa003300.47973639
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47665988
117Sphingolipid metabolism_Homo sapiens_hsa006000.46139091
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45872730
119Adherens junction_Homo sapiens_hsa045200.44841123
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.44262361
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43026670
122Biosynthesis of amino acids_Homo sapiens_hsa012300.42674697
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41644898
124TNF signaling pathway_Homo sapiens_hsa046680.40155554
125Estrogen signaling pathway_Homo sapiens_hsa049150.39586779
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39312808
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38093976
128Purine metabolism_Homo sapiens_hsa002300.37332028
129ECM-receptor interaction_Homo sapiens_hsa045120.37156813
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.36013926
131Tyrosine metabolism_Homo sapiens_hsa003500.34421176
132Tight junction_Homo sapiens_hsa045300.30477092

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