CLRN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the clarin family of genes. The clarins appear to belong to a large superfamily of small integral membrane glycoproteins with four transmembrane domains. The exact function of this gene is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)7.98621072
2regulation of chromatin binding (GO:0035561)7.42239177
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.78977745
4female mating behavior (GO:0060180)5.46456323
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.23556188
6regulation of female receptivity (GO:0045924)4.85913159
7neurofilament cytoskeleton organization (GO:0060052)4.53086017
8positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.40061312
9mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.40061312
10somatic hypermutation of immunoglobulin genes (GO:0016446)4.35463483
11somatic diversification of immune receptors via somatic mutation (GO:0002566)4.35463483
12ovulation cycle (GO:0042698)4.31890865
13G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.21875852
14cerebellar Purkinje cell differentiation (GO:0021702)4.17240143
15peptidyl-arginine omega-N-methylation (GO:0035247)4.15228991
16innervation (GO:0060384)4.11402382
17glial cell proliferation (GO:0014009)4.11313049
18cornea development in camera-type eye (GO:0061303)4.05542361
19positive regulation of mitochondrial membrane permeability (GO:0035794)3.91177831
20eyelid development in camera-type eye (GO:0061029)3.90150691
21glutamate secretion (GO:0014047)3.88218993
22regulation of synaptic vesicle exocytosis (GO:2000300)3.68383586
23alanine transport (GO:0032328)3.67450737
24negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.63716150
25regulation of neuronal synaptic plasticity (GO:0048168)3.60440421
26peptidyl-arginine N-methylation (GO:0035246)3.59282191
27peptidyl-arginine methylation (GO:0018216)3.59282191
28cell migration in hindbrain (GO:0021535)3.57344037
29atrial cardiac muscle cell action potential (GO:0086014)3.56606534
30synaptic vesicle maturation (GO:0016188)3.55992414
31negative regulation of glial cell proliferation (GO:0060253)3.53363821
32negative regulation of sodium ion transport (GO:0010766)3.51848026
33regulation of chemokine secretion (GO:0090196)3.48658870
34positive regulation of icosanoid secretion (GO:0032305)3.46952925
35regulation of hippo signaling (GO:0035330)3.44219189
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40953168
37limb bud formation (GO:0060174)3.38387204
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35087617
39somite development (GO:0061053)3.34275027
40positive regulation of fatty acid transport (GO:2000193)3.30077252
41low-density lipoprotein particle remodeling (GO:0034374)3.29283069
42cell communication by electrical coupling (GO:0010644)3.27430010
43pyrimidine nucleobase catabolic process (GO:0006208)3.25305268
44neuronal action potential propagation (GO:0019227)3.20910544
45positive regulation of neurotransmitter secretion (GO:0001956)3.16809274
46phosphorelay signal transduction system (GO:0000160)3.15833034
47cell communication involved in cardiac conduction (GO:0086065)3.14322462
48cardiac ventricle formation (GO:0003211)3.12294201
49positive regulation of prostaglandin secretion (GO:0032308)3.11971214
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11273392
51cellular potassium ion homeostasis (GO:0030007)3.07433033
52dosage compensation (GO:0007549)3.07209104
53negative regulation of dendrite morphogenesis (GO:0050774)3.05586268
54hippocampus development (GO:0021766)3.02926303
55purinergic nucleotide receptor signaling pathway (GO:0035590)2.99832205
56regulation of prostaglandin secretion (GO:0032306)2.98065303
57cardiac chamber formation (GO:0003207)2.97241530
58detection of temperature stimulus involved in sensory perception (GO:0050961)2.96978003
59detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.96978003
60regulation of respiratory system process (GO:0044065)2.92772751
61negative regulation of transcription regulatory region DNA binding (GO:2000678)2.90854727
62adipose tissue development (GO:0060612)2.90351639
63cellular sodium ion homeostasis (GO:0006883)2.89999395
64sodium ion export (GO:0071436)2.87189667
65proline transport (GO:0015824)2.86661961
66Sertoli cell development (GO:0060009)2.86624738
67calcium-mediated signaling using intracellular calcium source (GO:0035584)2.85162145
68detection of temperature stimulus (GO:0016048)2.81859899
69histone arginine methylation (GO:0034969)2.79693048
70regulation of superoxide anion generation (GO:0032928)2.78840230
71neural crest cell development (GO:0014032)2.78524799
72cellular response to nitric oxide (GO:0071732)2.77887583
73G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.76282073
74regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.75440950
75membrane depolarization during action potential (GO:0086010)2.74760271
76regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74584901
77respiratory system process (GO:0003016)2.74151145
78regulation of cholesterol esterification (GO:0010872)2.73225009
79regulation of icosanoid secretion (GO:0032303)2.71159762
80nucleobase catabolic process (GO:0046113)2.70778963
81establishment of monopolar cell polarity (GO:0061162)2.68232261
82establishment or maintenance of monopolar cell polarity (GO:0061339)2.68232261
83negative regulation of synaptic transmission, GABAergic (GO:0032229)2.66559894
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.66212619
85negative regulation of dendrite development (GO:2000171)2.65886852
86lens morphogenesis in camera-type eye (GO:0002089)2.64549869
87regulation of long-term neuronal synaptic plasticity (GO:0048169)2.64081266
88regulation of synaptic vesicle transport (GO:1902803)2.62292452
89regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.61474179
90membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.60840258
91regulation of glial cell proliferation (GO:0060251)2.60394077
92transmission of nerve impulse (GO:0019226)2.60118720
93positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.60012579
94positive regulation of potassium ion transport (GO:0043268)2.59864929
95regulation of double-strand break repair via homologous recombination (GO:0010569)2.58261641
96positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.57667278
97multicellular organismal reproductive behavior (GO:0033057)2.55814722
98L-serine transport (GO:0015825)2.53403453
99positive regulation of neurotransmitter transport (GO:0051590)2.52633520
100oligodendrocyte differentiation (GO:0048709)2.51156970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.26702446
2GBX2_23144817_ChIP-Seq_PC3_Human3.28757083
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85489361
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83074295
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82196562
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66484370
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66484370
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55240626
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.54684718
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51940092
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.39678540
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37059810
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.35049719
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.29352211
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.27873999
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27401856
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.19045261
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04968973
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04865306
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04085752
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02818091
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97397840
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96784449
24AHR_22903824_ChIP-Seq_MCF-7_Human1.84999752
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79150531
26TAF15_26573619_Chip-Seq_HEK293_Human1.77180038
27DROSHA_22980978_ChIP-Seq_HELA_Human1.68213943
28REST_21632747_ChIP-Seq_MESCs_Mouse1.67067780
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59348479
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.57319150
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55719173
32ZNF274_21170338_ChIP-Seq_K562_Hela1.55375293
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55013987
34TP53_20018659_ChIP-ChIP_R1E_Mouse1.52476053
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.46485588
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.46145235
37NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45507153
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.44996312
39P300_19829295_ChIP-Seq_ESCs_Human1.43278785
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.42643167
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.41046861
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40312627
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37278107
44SMAD4_21799915_ChIP-Seq_A2780_Human1.36857722
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.33844327
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33313373
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.31936333
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30214455
49BCAT_22108803_ChIP-Seq_LS180_Human1.29783733
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24436748
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21284552
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20548310
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20266058
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19438568
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19122272
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.17387242
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11213955
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11213955
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10601430
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10540328
61AR_25329375_ChIP-Seq_VCAP_Human1.10533410
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09791714
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.08561172
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06595666
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05358456
66TP53_18474530_ChIP-ChIP_U2OS_Human1.02387512
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01743500
68HTT_18923047_ChIP-ChIP_STHdh_Human1.00853950
69KDM2B_26808549_Chip-Seq_K562_Human1.00337209
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98599223
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98338351
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97647890
73RNF2_27304074_Chip-Seq_NSC_Mouse0.97274402
74ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96696270
75SMAD4_21741376_ChIP-Seq_HESCs_Human0.95655529
76OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95089833
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92377157
78ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89667197
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89201705
80AR_19668381_ChIP-Seq_PC3_Human0.89182297
81LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88718510
82IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88238855
83WT1_19549856_ChIP-ChIP_CCG9911_Human0.88153576
84TCF4_23295773_ChIP-Seq_U87_Human0.88010768
85SOX9_26525672_Chip-Seq_HEART_Mouse0.87913848
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86369889
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84961713
88CTCF_27219007_Chip-Seq_Bcells_Human0.84906262
89NANOG_18555785_Chip-Seq_ESCs_Mouse0.84817629
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.84766537
91STAT3_23295773_ChIP-Seq_U87_Human0.84525449
92ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84467218
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83763119
94SOX2_21211035_ChIP-Seq_LN229_Gbm0.83058017
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81366756
96ER_23166858_ChIP-Seq_MCF-7_Human0.81320832
97EGR1_19032775_ChIP-ChIP_M12_Human0.80410083
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78072247
99TAL1_26923725_Chip-Seq_HPCs_Mouse0.76008746
100RUNX2_22187159_ChIP-Seq_PCA_Human0.75909988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol5.42006839
2MP0004270_analgesia5.03148131
3MP0003787_abnormal_imprinting4.33777822
4MP0008789_abnormal_olfactory_epithelium4.24251153
5MP0005499_abnormal_olfactory_system3.91062832
6MP0005394_taste/olfaction_phenotype3.91062832
7MP0006276_abnormal_autonomic_nervous3.35419944
8MP0002735_abnormal_chemical_nociception2.94841039
9MP0001542_abnormal_bone_strength2.83086394
10MP0004858_abnormal_nervous_system2.69892676
11MP0004859_abnormal_synaptic_plasticity2.46011670
12MP0002160_abnormal_reproductive_system2.32469575
13MP0002184_abnormal_innervation2.21762555
14MP0002734_abnormal_mechanical_nocicepti2.21069501
15MP0004134_abnormal_chest_morphology2.20534483
16MP0002751_abnormal_autonomic_nervous2.11968280
17MP0005171_absent_coat_pigmentation2.08653097
18MP0000372_irregular_coat_pigmentation2.04169364
19MP0003635_abnormal_synaptic_transmissio2.03977255
20MP0003880_abnormal_central_pattern1.96761951
21MP0002272_abnormal_nervous_system1.86465729
22MP0002909_abnormal_adrenal_gland1.84946011
23MP0006292_abnormal_olfactory_placode1.81443273
24MP0005423_abnormal_somatic_nervous1.79995740
25MP0008877_abnormal_DNA_methylation1.79419994
26MP0001968_abnormal_touch/_nociception1.77192100
27MP0000778_abnormal_nervous_system1.74823424
28MP0003137_abnormal_impulse_conducting1.67583181
29MP0005085_abnormal_gallbladder_physiolo1.67130233
30MP0000003_abnormal_adipose_tissue1.65656761
31MP0002063_abnormal_learning/memory/cond1.62012780
32MP0002089_abnormal_postnatal_growth/wei1.56382545
33MP0002733_abnormal_thermal_nociception1.53704652
34MP0001440_abnormal_grooming_behavior1.50982511
35MP0002064_seizures1.48431153
36MP0002557_abnormal_social/conspecific_i1.48395679
37MP0004133_heterotaxia1.47513578
38MP0001958_emphysema1.43819797
39MP0002067_abnormal_sensory_capabilities1.39978336
40MP0009745_abnormal_behavioral_response1.39144466
41MP0001970_abnormal_pain_threshold1.36114886
42MP0002736_abnormal_nociception_after1.36076931
43MP0002168_other_aberrant_phenotype1.34807074
44MP0005623_abnormal_meninges_morphology1.33026297
45MP0009046_muscle_twitch1.27034352
46MP0004147_increased_porphyrin_level1.26900065
47MP0010030_abnormal_orbit_morphology1.21892901
48MP0004085_abnormal_heartbeat1.21783788
49MP0002572_abnormal_emotion/affect_behav1.20779599
50MP0001486_abnormal_startle_reflex1.17556720
51MP0000647_abnormal_sebaceous_gland1.15009963
52MP0002882_abnormal_neuron_morphology1.14155206
53MP0005389_reproductive_system_phenotype1.09014757
54MP0004811_abnormal_neuron_physiology1.06253394
55MP0001984_abnormal_olfaction1.05227480
56MP0004142_abnormal_muscle_tone1.04038382
57MP0003329_amyloid_beta_deposits1.03564671
58MP0004883_abnormal_blood_vessel1.03326552
59MP0001299_abnormal_eye_distance/1.02966234
60MP0005451_abnormal_body_composition1.01777311
61MP0005083_abnormal_biliary_tract0.99536633
62MP0003121_genomic_imprinting0.97676572
63MP0001485_abnormal_pinna_reflex0.92431257
64MP0002752_abnormal_somatic_nervous0.92207828
65MP0004924_abnormal_behavior0.91513757
66MP0005386_behavior/neurological_phenoty0.91513757
67MP0003878_abnormal_ear_physiology0.90391790
68MP0005377_hearing/vestibular/ear_phenot0.90391790
69MP0001963_abnormal_hearing_physiology0.89552628
70MP0008569_lethality_at_weaning0.89044762
71MP0008438_abnormal_cutaneous_collagen0.87678164
72MP0004885_abnormal_endolymph0.87263914
73MP0000955_abnormal_spinal_cord0.84885234
74MP0002233_abnormal_nose_morphology0.84832805
75MP0001502_abnormal_circadian_rhythm0.83688305
76MP0005595_abnormal_vascular_smooth0.82489827
77MP0003633_abnormal_nervous_system0.82001031
78MP0000026_abnormal_inner_ear0.80641355
79MP0002152_abnormal_brain_morphology0.76884004
80MP0002066_abnormal_motor_capabilities/c0.76811323
81MP0001986_abnormal_taste_sensitivity0.76535120
82MP0005375_adipose_tissue_phenotype0.75097053
83MP0003075_altered_response_to0.72758809
84MP0008058_abnormal_DNA_repair0.70179327
85MP0009703_decreased_birth_body0.69443213
86MP0001188_hyperpigmentation0.67543323
87MP0000920_abnormal_myelination0.66252553
88MP0003879_abnormal_hair_cell0.66220229
89MP0004185_abnormal_adipocyte_glucose0.65208945
90MP0004484_altered_response_of0.64784233
91MP0005166_decreased_susceptibility_to0.64588577
92MP0008874_decreased_physiological_sensi0.64339774
93MP0003690_abnormal_glial_cell0.63309782
94MP0005165_increased_susceptibility_to0.62941301
95MP0005365_abnormal_bile_salt0.62605273
96MP0003861_abnormal_nervous_system0.61592943
97MP0002972_abnormal_cardiac_muscle0.60894330
98MP0003631_nervous_system_phenotype0.60842723
99MP0001943_abnormal_respiration0.56201131
100MP0009672_abnormal_birth_weight0.55888018

Predicted human phenotypes

RankGene SetZ-score
1Pelvic girdle muscle weakness (HP:0003749)4.56091583
2Abnormality of the intervertebral disk (HP:0005108)4.30562492
3Spontaneous hematomas (HP:0007420)4.23400818
4Abnormality of the musculature of the pelvis (HP:0001469)4.19443298
5Abnormality of the hip-girdle musculature (HP:0001445)4.19443298
6Focal motor seizures (HP:0011153)4.06392900
7Mask-like facies (HP:0000298)3.98298302
8Myokymia (HP:0002411)3.93425880
9Palpebral edema (HP:0100540)3.90797352
10Hypothermia (HP:0002045)3.87511774
11Asymmetry of the thorax (HP:0001555)3.75570291
12Submucous cleft hard palate (HP:0000176)3.74271869
13Arterial tortuosity (HP:0005116)3.73479308
14Abnormality of the nasal septum (HP:0000419)3.70144095
15Abnormality of hair growth rate (HP:0011363)3.54555622
16Slow-growing hair (HP:0002217)3.54555622
17Multifactorial inheritance (HP:0001426)3.52127677
18Vascular tortuosity (HP:0004948)3.44470032
19Insomnia (HP:0100785)3.37236124
20Foot dorsiflexor weakness (HP:0009027)3.36299986
21Focal seizures (HP:0007359)3.29638610
22Febrile seizures (HP:0002373)3.07335076
23Supranuclear gaze palsy (HP:0000605)3.04197244
24Abnormality of the foot musculature (HP:0001436)2.98553820
25Ulnar claw (HP:0001178)2.96991188
26Renovascular hypertension (HP:0100817)2.90877136
27Generalized tonic-clonic seizures (HP:0002069)2.68106108
28Generalized hypotonia (HP:0001290)2.64831316
29Ankle clonus (HP:0011448)2.64628060
30Bradycardia (HP:0001662)2.57390942
31Hemiplegia (HP:0002301)2.54762246
32Patellar aplasia (HP:0006443)2.51615976
33Anosmia (HP:0000458)2.45436975
34Pheochromocytoma (HP:0002666)2.43209633
35Orthostatic hypotension (HP:0001278)2.40462142
36Arthropathy (HP:0003040)2.37212175
37Joint hemorrhage (HP:0005261)2.36877804
38Hemiparesis (HP:0001269)2.34916806
39Diplopia (HP:0000651)2.32003138
40Abnormality of binocular vision (HP:0011514)2.32003138
41Action tremor (HP:0002345)2.31707321
42Thyroid carcinoma (HP:0002890)2.30712417
43Meningioma (HP:0002858)2.30477411
44Epileptic encephalopathy (HP:0200134)2.26567514
45Lower limb muscle weakness (HP:0007340)2.25320641
46Limb-girdle muscle weakness (HP:0003325)2.24627573
47Aplasia/Hypoplasia of the patella (HP:0006498)2.24263578
48Atonic seizures (HP:0010819)2.23750782
49Exotropia (HP:0000577)2.23550664
50Abnormal ciliary motility (HP:0012262)2.21493530
51Broad distal phalanx of finger (HP:0009836)2.21449089
52Paraplegia (HP:0010550)2.18902714
53Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.18809249
54Abnormality of pain sensation (HP:0010832)2.17589909
55Impaired pain sensation (HP:0007328)2.17589909
56Amblyopia (HP:0000646)2.15717518
57Abnormality of the diencephalon (HP:0010662)2.12119274
58Increased serum pyruvate (HP:0003542)2.12085554
59Abnormality of glycolysis (HP:0004366)2.12085554
60Increased IgE level (HP:0003212)2.11955476
61Neuroendocrine neoplasm (HP:0100634)2.10954292
62Megalencephaly (HP:0001355)2.10568667
63Osteomalacia (HP:0002749)2.05078034
64Lower limb asymmetry (HP:0100559)2.04969881
65Elfin facies (HP:0004428)2.04194789
66Spinal cord lesions (HP:0100561)2.03974448
67Syringomyelia (HP:0003396)2.03974448
68Periorbital edema (HP:0100539)2.03645369
69Unsteady gait (HP:0002317)1.98576142
70Curly hair (HP:0002212)1.98049181
71Abnormal eating behavior (HP:0100738)1.97612611
72Hyperthyroidism (HP:0000836)1.96925055
73Facial edema (HP:0000282)1.96007203
74Spastic paraplegia (HP:0001258)1.95979813
75Hammertoe (HP:0001765)1.95795000
76Spina bifida occulta (HP:0003298)1.94174511
77Hamartoma (HP:0010566)1.91982466
78Exercise-induced myalgia (HP:0003738)1.90112786
79Bladder diverticulum (HP:0000015)1.88272081
80Potter facies (HP:0002009)1.87551496
81Facial shape deformation (HP:0011334)1.87551496
82Abnormal respiratory epithelium morphology (HP:0012253)1.85836094
83Abnormal respiratory motile cilium morphology (HP:0005938)1.85836094
84Hypoplasia of the brainstem (HP:0002365)1.84777721
85Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84777721
86Amyloidosis (HP:0011034)1.84560266
87Wrist flexion contracture (HP:0001239)1.82165842
88Soft skin (HP:0000977)1.81464447
89Short nail (HP:0001799)1.79954898
90Spastic gait (HP:0002064)1.77761184
91Melanoma (HP:0002861)1.76954848
92Sleep apnea (HP:0010535)1.74802573
93Vascular calcification (HP:0004934)1.74619097
94Cutis marmorata (HP:0000965)1.74566749
95Atrial fibrillation (HP:0005110)1.73142431
96Prolonged QT interval (HP:0001657)1.72604676
97Atelectasis (HP:0100750)1.71517214
98Cutaneous melanoma (HP:0012056)1.71426269
99Absent/shortened dynein arms (HP:0200106)1.70456156
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.70456156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K74.62263498
2DMPK4.32343487
3MAP3K44.10854552
4ERBB33.68726703
5MAP3K63.16062723
6SRPK13.09136995
7MAP2K43.03612282
8TNK23.01521038
9NTRK32.98777173
10MINK12.84214888
11CASK2.35255816
12BLK2.12949297
13TGFBR21.92287008
14LMTK21.76486455
15SGK4941.73411464
16SGK2231.73411464
17BMPR21.73327774
18MAPK131.71707650
19SGK21.58202697
20NTRK11.53682481
21NEK91.48935054
22PHKG11.34824767
23PHKG21.34824767
24MARK11.32579601
25NTRK21.31559043
26SIK11.30092932
27RAF11.23057392
28PLK21.20145886
29NUAK11.19945811
30LATS21.17446825
31WNK31.14192923
32ROCK21.09283023
33PAK61.07663859
34DYRK21.03108733
35RET1.01318797
36SIK31.01010429
37UHMK11.00640152
38KSR10.98277310
39SGK30.95640647
40ADRBK10.90508358
41WNK10.89263166
42PRKCG0.84480222
43YES10.78807818
44CLK10.78165642
45GRK60.71683247
46EPHA40.69623284
47KSR20.69404668
48PAK30.65607995
49CSNK1G20.65602552
50CDK50.65546628
51STK390.64874435
52MAPK40.62630306
53STK380.61145896
54MAP3K90.60508560
55TNIK0.59697588
56DAPK20.59126356
57RPS6KA20.58901387
58ROCK10.58065431
59BCR0.57645222
60MAP3K50.57125721
61CAMK2A0.52513705
62JAK30.51792909
63MYLK0.51700457
64MATK0.51386492
65GRK70.50414142
66PRKCE0.50118676
67GRK50.48173366
68MAP2K10.47206596
69INSRR0.46712054
70PRKCH0.45163391
71CDK180.44833623
72PRKCD0.43529653
73CDK140.43210544
74FES0.41533406
75CAMKK20.40925827
76PRKACA0.40057346
77GSK3B0.38478981
78FGFR40.38379413
79CDK190.38362802
80PRKCZ0.37587051
81LIMK10.37445378
82CDK150.37385863
83RIPK40.37085047
84SIK20.36242989
85PRKG10.35473278
86IRAK40.35321703
87FER0.35198318
88BRSK10.34960618
89CAMK2G0.34384957
90OXSR10.33103119
91CAMK40.32797600
92ILK0.32496032
93CAMKK10.32255854
94GRK10.30563526
95MAP3K120.29855460
96CDK11A0.27887564
97PRKCQ0.27850555
98PRKACB0.26492953
99MAPK120.25918136
100PRKCA0.25870181

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.22464328
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.92999286
3Synaptic vesicle cycle_Homo sapiens_hsa047212.64678688
4Nicotine addiction_Homo sapiens_hsa050332.48406616
5GABAergic synapse_Homo sapiens_hsa047272.21932308
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02823991
7Olfactory transduction_Homo sapiens_hsa047401.95961935
8Circadian entrainment_Homo sapiens_hsa047131.83312599
9Glutamatergic synapse_Homo sapiens_hsa047241.75465626
10Cholinergic synapse_Homo sapiens_hsa047251.70028980
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.67484611
12Morphine addiction_Homo sapiens_hsa050321.64425464
13Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.61305412
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56873426
15Ether lipid metabolism_Homo sapiens_hsa005651.53891524
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48900464
17Dopaminergic synapse_Homo sapiens_hsa047281.45874984
18Serotonergic synapse_Homo sapiens_hsa047261.45372688
19Nitrogen metabolism_Homo sapiens_hsa009101.45202912
20Type II diabetes mellitus_Homo sapiens_hsa049301.39786706
21Gastric acid secretion_Homo sapiens_hsa049711.37028943
22Taste transduction_Homo sapiens_hsa047421.35700720
23Long-term potentiation_Homo sapiens_hsa047201.34151590
24Salivary secretion_Homo sapiens_hsa049701.34046386
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33778665
26Bile secretion_Homo sapiens_hsa049761.31361722
27Insulin secretion_Homo sapiens_hsa049111.29152345
28Axon guidance_Homo sapiens_hsa043601.25209932
29Fatty acid biosynthesis_Homo sapiens_hsa000611.19673795
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.17757869
31Ras signaling pathway_Homo sapiens_hsa040141.15233924
32ErbB signaling pathway_Homo sapiens_hsa040121.06336801
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03523108
34Renin secretion_Homo sapiens_hsa049240.98439268
35Oxytocin signaling pathway_Homo sapiens_hsa049210.95888804
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95581374
37Linoleic acid metabolism_Homo sapiens_hsa005910.95355738
38Long-term depression_Homo sapiens_hsa047300.94790277
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93668545
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91768845
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90380106
42Steroid biosynthesis_Homo sapiens_hsa001000.89992782
43Glioma_Homo sapiens_hsa052140.89244025
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87638984
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87489267
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86562941
47Melanoma_Homo sapiens_hsa052180.82371418
48Choline metabolism in cancer_Homo sapiens_hsa052310.81258914
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80805210
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.80508364
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79263571
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79136127
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78229915
54cAMP signaling pathway_Homo sapiens_hsa040240.78033605
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76696740
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75712245
57Fatty acid metabolism_Homo sapiens_hsa012120.75110436
58Notch signaling pathway_Homo sapiens_hsa043300.74717466
59Amphetamine addiction_Homo sapiens_hsa050310.74464077
60Vibrio cholerae infection_Homo sapiens_hsa051100.72844981
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.72775439
62Fat digestion and absorption_Homo sapiens_hsa049750.71630965
63Collecting duct acid secretion_Homo sapiens_hsa049660.71129267
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71090894
65GnRH signaling pathway_Homo sapiens_hsa049120.70813456
66Melanogenesis_Homo sapiens_hsa049160.68939158
67Cardiac muscle contraction_Homo sapiens_hsa042600.68918544
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68394372
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67917028
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66547887
71Renin-angiotensin system_Homo sapiens_hsa046140.66037743
72Calcium signaling pathway_Homo sapiens_hsa040200.64503219
73VEGF signaling pathway_Homo sapiens_hsa043700.64370571
74Prolactin signaling pathway_Homo sapiens_hsa049170.63334623
75Arginine biosynthesis_Homo sapiens_hsa002200.62047561
76Pancreatic secretion_Homo sapiens_hsa049720.61698462
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61291609
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61283454
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59927628
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57037384
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57007643
82Gap junction_Homo sapiens_hsa045400.54694538
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53809308
84Endometrial cancer_Homo sapiens_hsa052130.53556298
85Fatty acid degradation_Homo sapiens_hsa000710.52551119
86Fatty acid elongation_Homo sapiens_hsa000620.52097042
87Hedgehog signaling pathway_Homo sapiens_hsa043400.50268159
88Rap1 signaling pathway_Homo sapiens_hsa040150.50025145
89Colorectal cancer_Homo sapiens_hsa052100.49749008
90Dilated cardiomyopathy_Homo sapiens_hsa054140.47159889
91Estrogen signaling pathway_Homo sapiens_hsa049150.46877321
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.46725938
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.44486621
94Salmonella infection_Homo sapiens_hsa051320.44010862
95Pancreatic cancer_Homo sapiens_hsa052120.43258968
96Oxidative phosphorylation_Homo sapiens_hsa001900.42511180
97Arachidonic acid metabolism_Homo sapiens_hsa005900.42312390
98Hepatitis C_Homo sapiens_hsa051600.41049187
99Alzheimers disease_Homo sapiens_hsa050100.40937834
100Tight junction_Homo sapiens_hsa045300.40890408

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