CLNS1AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribonucleoprotein complex disassembly (GO:0032988)6.33507463
2platelet dense granule organization (GO:0060155)5.18171985
3glycerophospholipid catabolic process (GO:0046475)5.16321320
4organelle disassembly (GO:1903008)4.74857943
5tryptophan catabolic process (GO:0006569)4.68599984
6indole-containing compound catabolic process (GO:0042436)4.68599984
7indolalkylamine catabolic process (GO:0046218)4.68599984
8behavioral response to nicotine (GO:0035095)4.48373741
9kynurenine metabolic process (GO:0070189)4.40814698
10DNA deamination (GO:0045006)4.33670404
11gamma-aminobutyric acid transport (GO:0015812)4.28143548
12activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.25314473
13tryptophan metabolic process (GO:0006568)4.23166249
14indolalkylamine metabolic process (GO:0006586)4.12420335
15negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.11495248
16negative regulation of execution phase of apoptosis (GO:1900118)3.91733922
17negative regulation of synaptic transmission, GABAergic (GO:0032229)3.83583103
18parturition (GO:0007567)3.83393112
19detection of light stimulus involved in sensory perception (GO:0050962)3.78891618
20detection of light stimulus involved in visual perception (GO:0050908)3.78891618
21prenylation (GO:0097354)3.73766412
22protein prenylation (GO:0018342)3.73766412
23regulation of isotype switching to IgG isotypes (GO:0048302)3.68335343
24phosphatidylserine acyl-chain remodeling (GO:0036150)3.62216831
25righting reflex (GO:0060013)3.57577937
26immunoglobulin mediated immune response (GO:0016064)3.50347465
27purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.46797829
28mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.43244012
29positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.43244012
30GTP biosynthetic process (GO:0006183)3.38988710
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38194756
32positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.36617114
33phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.33372815
34negative regulation of chemokine production (GO:0032682)3.32566872
35RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.30474440
36phosphatidylcholine acyl-chain remodeling (GO:0036151)3.26597543
37dopamine transport (GO:0015872)3.26330691
38amine catabolic process (GO:0009310)3.22301622
39cellular biogenic amine catabolic process (GO:0042402)3.22301622
40ribosomal small subunit assembly (GO:0000028)3.22221371
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.22002007
42synaptic transmission, cholinergic (GO:0007271)3.21839371
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17002308
44signal peptide processing (GO:0006465)3.13802462
45positive regulation of cAMP-mediated signaling (GO:0043950)3.12673348
46sleep (GO:0030431)3.11704408
47phosphatidylinositol acyl-chain remodeling (GO:0036149)3.09267255
48aggressive behavior (GO:0002118)3.08450874
49L-fucose catabolic process (GO:0042355)3.07821698
50fucose catabolic process (GO:0019317)3.07821698
51L-fucose metabolic process (GO:0042354)3.07821698
52reflex (GO:0060004)2.98614938
53icosanoid secretion (GO:0032309)2.95389684
54arachidonic acid secretion (GO:0050482)2.95389684
55cytokine biosynthetic process (GO:0042089)2.94296301
56T cell migration (GO:0072678)2.93509615
57seminiferous tubule development (GO:0072520)2.91988535
58mannosylation (GO:0097502)2.91880227
59preassembly of GPI anchor in ER membrane (GO:0016254)2.91832740
60electron transport chain (GO:0022900)2.88627393
61positive regulation of isotype switching (GO:0045830)2.88388396
62regulation of execution phase of apoptosis (GO:1900117)2.86359936
63cytolysis (GO:0019835)2.86328466
64energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84808981
65ATP synthesis coupled proton transport (GO:0015986)2.84808981
66indole-containing compound metabolic process (GO:0042430)2.84170001
67respiratory electron transport chain (GO:0022904)2.82532721
68negative regulation of interleukin-8 production (GO:0032717)2.80987025
69UTP biosynthetic process (GO:0006228)2.80815965
70regulation of chronic inflammatory response (GO:0002676)2.78362122
71positive regulation of protein homodimerization activity (GO:0090073)2.77615543
72metallo-sulfur cluster assembly (GO:0031163)2.77026489
73iron-sulfur cluster assembly (GO:0016226)2.77026489
74negative regulation of mast cell activation (GO:0033004)2.75864811
75negative regulation of calcium ion transport into cytosol (GO:0010523)2.74762879
76lymphocyte chemotaxis (GO:0048247)2.74005387
77neuronal action potential (GO:0019228)2.73083439
78regulation of rhodopsin mediated signaling pathway (GO:0022400)2.72587176
79positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.71594570
80benzene-containing compound metabolic process (GO:0042537)2.71399379
81UTP metabolic process (GO:0046051)2.71041241
82B cell mediated immunity (GO:0019724)2.69830127
83anterograde synaptic vesicle transport (GO:0048490)2.67944620
84ncRNA 3-end processing (GO:0043628)2.66359775
85negative regulation of telomere maintenance (GO:0032205)2.65044267
86receptor guanylyl cyclase signaling pathway (GO:0007168)2.64050278
87serotonin receptor signaling pathway (GO:0007210)2.62177447
88positive regulation of DNA recombination (GO:0045911)2.60771244
89regulation of hypersensitivity (GO:0002883)2.59931061
90phospholipid catabolic process (GO:0009395)2.57895484
91regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.57736787
92protein import into peroxisome matrix (GO:0016558)2.57618786
93adenosine metabolic process (GO:0046085)2.55050778
94piRNA metabolic process (GO:0034587)2.54952780
95purine deoxyribonucleotide metabolic process (GO:0009151)2.53843747
96DNA dealkylation (GO:0035510)2.52358522
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.52103754
98phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.49793445
99negative regulation of acute inflammatory response (GO:0002674)2.49404133
100behavioral response to ethanol (GO:0048149)2.49226058

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.42782696
2ZNF274_21170338_ChIP-Seq_K562_Hela3.26313288
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.07888081
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02708431
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.46206059
6FUS_26573619_Chip-Seq_HEK293_Human2.36348173
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33237903
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30915544
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28087102
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25135026
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.20216451
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.18983744
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02374126
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93231354
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85804686
16GBX2_23144817_ChIP-Seq_PC3_Human1.82710916
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.78056799
18IGF1R_20145208_ChIP-Seq_DFB_Human1.71627216
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.71213811
20TAF15_26573619_Chip-Seq_HEK293_Human1.70337178
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68683133
22VDR_23849224_ChIP-Seq_CD4+_Human1.67991550
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64577270
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.59167844
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49531025
26TP53_22573176_ChIP-Seq_HFKS_Human1.49199921
27EWS_26573619_Chip-Seq_HEK293_Human1.49072957
28GATA3_26560356_Chip-Seq_TH2_Human1.48367573
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46613621
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45800686
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45479248
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44676963
33CBP_20019798_ChIP-Seq_JUKART_Human1.44676963
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44464870
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44035400
36ELK1_19687146_ChIP-ChIP_HELA_Human1.43936155
37P300_19829295_ChIP-Seq_ESCs_Human1.43376371
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42793046
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42793046
40TAF2_19829295_ChIP-Seq_ESCs_Human1.42655348
41NCOR_22424771_ChIP-Seq_293T_Human1.40995765
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.40839606
43MYC_18940864_ChIP-ChIP_HL60_Human1.40706053
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40440719
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.39697421
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38165292
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.38165292
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36528522
49FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34225159
50AR_20517297_ChIP-Seq_VCAP_Human1.33978937
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33666160
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.33527194
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33112051
54RNF2_27304074_Chip-Seq_NSC_Mouse1.32858854
55IRF1_19129219_ChIP-ChIP_H3396_Human1.30945803
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30911139
57PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30390380
58MYC_19829295_ChIP-Seq_ESCs_Human1.29282056
59FOXP3_21729870_ChIP-Seq_TREG_Human1.28375064
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26451235
61NANOG_19829295_ChIP-Seq_ESCs_Human1.25767337
62SOX2_19829295_ChIP-Seq_ESCs_Human1.25767337
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25344347
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.24014657
65REST_21632747_ChIP-Seq_MESCs_Mouse1.21835743
66ERG_20517297_ChIP-Seq_VCAP_Human1.20939078
67ER_23166858_ChIP-Seq_MCF-7_Human1.20667662
68ERA_21632823_ChIP-Seq_H3396_Human1.15694464
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15285400
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12513717
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.12153503
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08399830
73STAT3_23295773_ChIP-Seq_U87_Human1.07555414
74BCAT_22108803_ChIP-Seq_LS180_Human1.06464939
75RAC3_21632823_ChIP-Seq_H3396_Human1.06017825
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.05064474
77RBPJ_21746931_ChIP-Seq_IB4_Human1.04711549
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04578347
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.00406729
80TCF4_22108803_ChIP-Seq_LS180_Human1.00339388
81PRDM14_20953172_ChIP-Seq_ESCs_Human0.97163106
82KAP1_22055183_ChIP-Seq_ESCs_Mouse0.97060776
83SALL4_22934838_ChIP-ChIP_CD34+_Human0.96513210
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.95282031
85HTT_18923047_ChIP-ChIP_STHdh_Human0.95155018
86GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94142967
87ETV1_20927104_ChIP-Seq_GIST48_Human0.93715989
88SRF_21415370_ChIP-Seq_HL-1_Mouse0.93260313
89IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92950150
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92526689
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92163629
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91542350
93P53_21459846_ChIP-Seq_SAOS-2_Human0.90180596
94PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89575930
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89255786
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.89086859
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87031669
98EZH2_22144423_ChIP-Seq_EOC_Human0.86808047
99CBX2_22325352_ChIP-Seq_293T-Rex_Human0.86185823
100SMAD4_21799915_ChIP-Seq_A2780_Human0.85951936

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.74748062
2MP0003195_calcinosis3.21414392
3MP0000372_irregular_coat_pigmentation3.13290017
4MP0000569_abnormal_digit_pigmentation3.10925186
5MP0005671_abnormal_response_to2.99623549
6MP0002102_abnormal_ear_morphology2.43039836
7MP0001529_abnormal_vocalization2.31892091
8MP0004885_abnormal_endolymph2.21361134
9MP0009046_muscle_twitch2.13616030
10MP0005551_abnormal_eye_electrophysiolog2.03828900
11MP0001835_abnormal_antigen_presentation1.98334717
12MP0003646_muscle_fatigue1.95453406
13MP0002138_abnormal_hepatobiliary_system1.83919153
14MP0005451_abnormal_body_composition1.81497759
15MP0004043_abnormal_pH_regulation1.74686461
16MP0004145_abnormal_muscle_electrophysio1.73629490
17MP0001486_abnormal_startle_reflex1.73499594
18MP0006036_abnormal_mitochondrial_physio1.68584751
19MP0003045_fibrosis1.66083592
20MP0003137_abnormal_impulse_conducting1.59724198
21MP0002272_abnormal_nervous_system1.58334592
22MP0009745_abnormal_behavioral_response1.56817453
23MP0002095_abnormal_skin_pigmentation1.56591181
24MP0008875_abnormal_xenobiotic_pharmacok1.56226875
25MP0008995_early_reproductive_senescence1.54008550
26MP0002163_abnormal_gland_morphology1.51698565
27MP0004859_abnormal_synaptic_plasticity1.50333493
28MP0005253_abnormal_eye_physiology1.49282063
29MP0001664_abnormal_digestion1.47692268
30MP0000015_abnormal_ear_pigmentation1.44838347
31MP0000427_abnormal_hair_cycle1.44741862
32MP0002277_abnormal_respiratory_mucosa1.44713316
33MP0003567_abnormal_fetal_cardiomyocyte1.44070565
34MP0008872_abnormal_physiological_respon1.37752682
35MP0003656_abnormal_erythrocyte_physiolo1.33178626
36MP0009785_altered_susceptibility_to1.32181941
37MP0000647_abnormal_sebaceous_gland1.32154683
38MP0001968_abnormal_touch/_nociception1.31935574
39MP0001905_abnormal_dopamine_level1.30845030
40MP0003879_abnormal_hair_cell1.29467409
41MP0008775_abnormal_heart_ventricle1.26970473
42MP0004484_altered_response_of1.26772229
43MP0005075_abnormal_melanosome_morpholog1.25586305
44MP0004924_abnormal_behavior1.24767156
45MP0005386_behavior/neurological_phenoty1.24767156
46MP0010386_abnormal_urinary_bladder1.24409210
47MP0003718_maternal_effect1.23969540
48MP0003300_gastrointestinal_ulcer1.23923301
49MP0002733_abnormal_thermal_nociception1.23024220
50MP0002735_abnormal_chemical_nociception1.22426772
51MP0002736_abnormal_nociception_after1.20823948
52MP0001970_abnormal_pain_threshold1.20560639
53MP0005379_endocrine/exocrine_gland_phen1.19944185
54MP0002876_abnormal_thyroid_physiology1.18141681
55MP0001440_abnormal_grooming_behavior1.17725763
56MP0001873_stomach_inflammation1.15159227
57MP0005332_abnormal_amino_acid1.15016416
58MP0008961_abnormal_basal_metabolism1.13638359
59MP0001188_hyperpigmentation1.12252872
60MP0000639_abnormal_adrenal_gland1.11809877
61MP0002064_seizures1.11673289
62MP0003806_abnormal_nucleotide_metabolis1.10725340
63MP0002928_abnormal_bile_duct1.08921200
64MP0001764_abnormal_homeostasis1.08426690
65MP0006072_abnormal_retinal_apoptosis1.07744945
66MP0002106_abnormal_muscle_physiology1.06853330
67MP0000383_abnormal_hair_follicle1.06048703
68MP0002572_abnormal_emotion/affect_behav1.06030770
69MP0002557_abnormal_social/conspecific_i1.05415384
70MP0004215_abnormal_myocardial_fiber1.03751445
71MP0002282_abnormal_trachea_morphology1.03275888
72MP0002090_abnormal_vision1.01241003
73MP0006276_abnormal_autonomic_nervous1.00751956
74MP0004142_abnormal_muscle_tone0.96496180
75MP0009764_decreased_sensitivity_to0.96473682
76MP0001765_abnormal_ion_homeostasis0.95350140
77MP0002148_abnormal_hypersensitivity_rea0.94940916
78MP0005646_abnormal_pituitary_gland0.93566886
79MP0005165_increased_susceptibility_to0.92907543
80MP0006082_CNS_inflammation0.92199935
81MP0005174_abnormal_tail_pigmentation0.91491782
82MP0005310_abnormal_salivary_gland0.87636958
83MP0002822_catalepsy0.86675452
84MP0005025_abnormal_response_to0.86199697
85MP0002332_abnormal_exercise_endurance0.85545224
86MP0004085_abnormal_heartbeat0.82173420
87MP0000343_altered_response_to0.81496348
88MP0002734_abnormal_mechanical_nocicepti0.79238485
89MP0000538_abnormal_urinary_bladder0.78756441
90MP0004084_abnormal_cardiac_muscle0.78446722
91MP0005369_muscle_phenotype0.76965909
92MP0000230_abnormal_systemic_arterial0.74670724
93MP0002166_altered_tumor_susceptibility0.74565883
94MP0003252_abnormal_bile_duct0.74156287
95MP0001348_abnormal_lacrimal_gland0.73817689
96MP0006035_abnormal_mitochondrial_morpho0.72850484
97MP0008877_abnormal_DNA_methylation0.72828837
98MP0001501_abnormal_sleep_pattern0.72807483
99MP0005167_abnormal_blood-brain_barrier0.70978329
100MP0000013_abnormal_adipose_tissue0.70878908

Predicted human phenotypes

RankGene SetZ-score
1Decreased central vision (HP:0007663)4.34957662
2Decreased electroretinogram (ERG) amplitude (HP:0000654)4.11652313
3Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10773957
4Hypothermia (HP:0002045)4.06038921
5Absent rod-and cone-mediated responses on ERG (HP:0007688)3.95844616
6Methylmalonic acidemia (HP:0002912)3.84174415
7Focal motor seizures (HP:0011153)3.72133040
8Acute necrotizing encephalopathy (HP:0006965)3.58995382
9Aplastic anemia (HP:0001915)3.58101145
10Abnormality of homocysteine metabolism (HP:0010919)3.41356960
11Homocystinuria (HP:0002156)3.41356960
12Congenital stationary night blindness (HP:0007642)3.32126154
13Acute encephalopathy (HP:0006846)3.19821743
14Generalized aminoaciduria (HP:0002909)3.19644123
15Abnormal mitochondria in muscle tissue (HP:0008316)3.11664894
16Elevated erythrocyte sedimentation rate (HP:0003565)3.10729729
17Type 2 muscle fiber atrophy (HP:0003554)3.06443605
18Pancreatic cysts (HP:0001737)3.04952741
19Abnormal rod and cone electroretinograms (HP:0008323)3.01074074
20Progressive macrocephaly (HP:0004481)2.91415885
21Type II lissencephaly (HP:0007260)2.87944374
22Methylmalonic aciduria (HP:0012120)2.80627715
23CNS hypomyelination (HP:0003429)2.75954480
24True hermaphroditism (HP:0010459)2.75757360
25Visual hallucinations (HP:0002367)2.70733100
26Pancreatic fibrosis (HP:0100732)2.68556415
27Increased corneal curvature (HP:0100692)2.68511972
28Keratoconus (HP:0000563)2.68511972
29Mitral stenosis (HP:0001718)2.64923834
30Increased CSF lactate (HP:0002490)2.60887323
31Muscle fiber atrophy (HP:0100295)2.59198837
32Absent/shortened dynein arms (HP:0200106)2.57541212
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.57541212
34Chronic hepatic failure (HP:0100626)2.56582471
35Abnormality of the prostate (HP:0008775)2.48053637
36Attenuation of retinal blood vessels (HP:0007843)2.47956387
37Opisthotonus (HP:0002179)2.46628274
38Focal seizures (HP:0007359)2.43676706
39Mitochondrial inheritance (HP:0001427)2.41822315
40Inability to walk (HP:0002540)2.40482448
41Abolished electroretinogram (ERG) (HP:0000550)2.36875143
42Cerebral edema (HP:0002181)2.33158167
43Molar tooth sign on MRI (HP:0002419)2.32298238
44Abnormality of midbrain morphology (HP:0002418)2.32298238
45Tongue fasciculations (HP:0001308)2.31187734
46Abnormality of methionine metabolism (HP:0010901)2.30342388
47Abnormality of the vitamin B12 metabolism (HP:0004341)2.28537923
48Abnormal respiratory epithelium morphology (HP:0012253)2.25515105
49Abnormal respiratory motile cilium morphology (HP:0005938)2.25515105
50Dialeptic seizures (HP:0011146)2.23344329
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20067112
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20067112
53Abnormality of the pubic bones (HP:0003172)2.19290131
54Portal hypertension (HP:0001409)2.18930634
55Hepatic necrosis (HP:0002605)2.16064792
56Sclerocornea (HP:0000647)2.15233693
57Absence seizures (HP:0002121)2.14026647
58Increased serum lactate (HP:0002151)2.12014755
59Type I transferrin isoform profile (HP:0003642)2.10596163
60Congenital, generalized hypertrichosis (HP:0004540)2.10403063
61Aplasia/Hypoplasia of the macula (HP:0008059)2.10358437
62Bony spicule pigmentary retinopathy (HP:0007737)2.10301852
63Hepatocellular necrosis (HP:0001404)2.09930107
64Palpitations (HP:0001962)2.09770649
65Constricted visual fields (HP:0001133)2.09631173
66Abnormality of vitamin B metabolism (HP:0004340)2.09476809
67Abnormality of sulfur amino acid metabolism (HP:0004339)2.08465858
68Aplasia/Hypoplasia affecting the retina (HP:0008061)2.07885460
69Aplasia/Hypoplasia of the tibia (HP:0005772)2.07841735
70Abnormality of serum amino acid levels (HP:0003112)2.07787384
71Cystic liver disease (HP:0006706)2.07430066
72Lethargy (HP:0001254)2.04761336
73Optic disc pallor (HP:0000543)2.00303800
74Late onset (HP:0003584)1.97019340
75Abnormality of the hepatic vasculature (HP:0006707)1.96423673
76Menstrual irregularities (HP:0000858)1.95606725
77Retinal dysplasia (HP:0007973)1.93722091
78Leukodystrophy (HP:0002415)1.92615104
79Muscle fibrillation (HP:0010546)1.90331289
80Pachygyria (HP:0001302)1.90260419
81Pendular nystagmus (HP:0012043)1.89592896
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87883052
83Abnormal protein glycosylation (HP:0012346)1.87186010
84Abnormal glycosylation (HP:0012345)1.87186010
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87186010
86Abnormal protein N-linked glycosylation (HP:0012347)1.87186010
87Fibular aplasia (HP:0002990)1.86536442
88Occipital encephalocele (HP:0002085)1.86385941
89Nephronophthisis (HP:0000090)1.85597700
90Brushfield spots (HP:0001088)1.85512466
91Lactic acidosis (HP:0003128)1.84630912
92Myokymia (HP:0002411)1.82120775
93Cerebellar dysplasia (HP:0007033)1.81365078
94Limb dystonia (HP:0002451)1.81317048
95Lissencephaly (HP:0001339)1.81252620
96Nonprogressive disorder (HP:0003680)1.81204874
97Large for gestational age (HP:0001520)1.80440054
98Neonatal respiratory distress (HP:0002643)1.77821641
99Prostate neoplasm (HP:0100787)1.75261663
100Generalized tonic-clonic seizures (HP:0002069)1.75145158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK167.89472712
2BCKDK3.57718497
3FRK3.18278386
4TAOK32.82609589
5MAP4K22.74963515
6ADRBK22.61205458
7PIK3CG2.32759912
8RIPK42.23003193
9LMTK22.05635235
10TLK11.97563741
11MKNK11.82470210
12ITK1.70522362
13NME11.47616378
14STK38L1.47176288
15BMPR1B1.42372387
16ZAK1.41989467
17BMPR21.36368319
18MAPK131.31731362
19OBSCN1.28100634
20MKNK21.27709284
21GRK11.22494120
22MAPKAPK51.21070866
23TXK1.18697100
24NEK11.16515681
25SIK31.15018781
26CAMKK21.09031060
27ILK1.06881439
28AKT31.06664611
29WNK31.06556117
30NUAK11.05482221
31CDK81.03188477
32TRPM70.98492870
33ERBB30.96648858
34PRKCE0.94121275
35BCR0.93206833
36ADRBK10.91540219
37BRSK20.88775885
38CSNK1A1L0.88385720
39MAPKAPK30.87959224
40FES0.87506599
41PBK0.87078228
42MAP3K120.86283207
43CSNK1G30.85805221
44CAMK2A0.82157926
45IKBKB0.78875190
46KIT0.76669305
47PRKCG0.76195815
48PKN20.75868815
49CSNK1G20.75484167
50MYLK0.74924892
51DAPK10.74258597
52CLK10.72364310
53MAP2K70.71698102
54SYK0.69543325
55TEC0.69475592
56PIK3CA0.68347775
57FLT30.67027991
58WNK40.65800785
59LYN0.64219456
60PHKG10.64194121
61PHKG20.64194121
62MAP3K40.64093552
63LCK0.62597352
64PKN10.61745381
65IGF1R0.60912267
66PRKG10.60670704
67DAPK30.59548717
68TSSK60.57813133
69PINK10.56816887
70TIE10.56705751
71OXSR10.55789059
72INSRR0.55601117
73RPS6KA50.54514501
74KDR0.54363874
75TRIM280.54046576
76CDK40.53783393
77ACVR1B0.53265447
78GRK50.50726382
79PRKACG0.50428378
80NTRK30.49863564
81EIF2AK10.49561896
82MAP2K60.49488891
83PRKACA0.47794860
84DDR20.47590806
85CSNK1G10.47535155
86PRKCA0.47223895
87PLK20.47202135
88MINK10.46977085
89SRPK10.46254127
90JAK30.45256713
91EGFR0.44729410
92PTK2B0.44246856
93CCNB10.44163190
94PRKCQ0.43335748
95BRD40.42819162
96STK390.42643370
97FER0.39147486
98TBK10.39033211
99ABL10.38772265
100GRK70.38375785

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.58117462
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.63892698
3Allograft rejection_Homo sapiens_hsa053303.35201152
4Autoimmune thyroid disease_Homo sapiens_hsa053203.21356609
5Linoleic acid metabolism_Homo sapiens_hsa005912.80057176
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.79191400
7Phototransduction_Homo sapiens_hsa047442.55990286
8Type I diabetes mellitus_Homo sapiens_hsa049402.44716651
9Oxidative phosphorylation_Homo sapiens_hsa001902.42844137
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42524297
11Graft-versus-host disease_Homo sapiens_hsa053322.36265817
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10835218
13Parkinsons disease_Homo sapiens_hsa050122.10358917
14Nitrogen metabolism_Homo sapiens_hsa009101.84483639
15One carbon pool by folate_Homo sapiens_hsa006701.76995347
16Arachidonic acid metabolism_Homo sapiens_hsa005901.71278513
17Ether lipid metabolism_Homo sapiens_hsa005651.65587207
18Peroxisome_Homo sapiens_hsa041461.61381321
19Olfactory transduction_Homo sapiens_hsa047401.58940568
20beta-Alanine metabolism_Homo sapiens_hsa004101.55665688
21Nicotine addiction_Homo sapiens_hsa050331.45317281
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38102965
23Protein export_Homo sapiens_hsa030601.31589370
24Butanoate metabolism_Homo sapiens_hsa006501.28922743
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28402468
26Legionellosis_Homo sapiens_hsa051341.27659363
27Antigen processing and presentation_Homo sapiens_hsa046121.26230485
28Viral myocarditis_Homo sapiens_hsa054161.24073514
29Rheumatoid arthritis_Homo sapiens_hsa053231.23873003
30Alzheimers disease_Homo sapiens_hsa050101.20289819
31Cardiac muscle contraction_Homo sapiens_hsa042601.19487920
32Tryptophan metabolism_Homo sapiens_hsa003801.18975929
33RNA polymerase_Homo sapiens_hsa030201.17926259
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17283414
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11510462
36Collecting duct acid secretion_Homo sapiens_hsa049661.10098397
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.08500578
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04587284
39Proteasome_Homo sapiens_hsa030501.01772228
40Huntingtons disease_Homo sapiens_hsa050161.01275628
41Histidine metabolism_Homo sapiens_hsa003401.00703051
42Serotonergic synapse_Homo sapiens_hsa047261.00229510
43Primary immunodeficiency_Homo sapiens_hsa053401.00000145
44Caffeine metabolism_Homo sapiens_hsa002320.99917159
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99706573
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96684333
47Ribosome_Homo sapiens_hsa030100.96454428
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91790619
49GABAergic synapse_Homo sapiens_hsa047270.90253737
50Selenocompound metabolism_Homo sapiens_hsa004500.88448693
51Purine metabolism_Homo sapiens_hsa002300.84334669
52Ovarian steroidogenesis_Homo sapiens_hsa049130.84031617
53Morphine addiction_Homo sapiens_hsa050320.80821462
54Staphylococcus aureus infection_Homo sapiens_hsa051500.79659240
55Glutathione metabolism_Homo sapiens_hsa004800.72765076
56Propanoate metabolism_Homo sapiens_hsa006400.70675288
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69109157
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68460178
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67759579
60ABC transporters_Homo sapiens_hsa020100.65399898
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64225027
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62460604
63Hematopoietic cell lineage_Homo sapiens_hsa046400.59694957
64Glutamatergic synapse_Homo sapiens_hsa047240.59509350
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59197915
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58085131
67Sulfur relay system_Homo sapiens_hsa041220.55837304
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.55719487
69Fanconi anemia pathway_Homo sapiens_hsa034600.55476998
70Arginine biosynthesis_Homo sapiens_hsa002200.54306154
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51734193
72Retinol metabolism_Homo sapiens_hsa008300.50106264
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50052011
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48588732
75Taste transduction_Homo sapiens_hsa047420.47891910
76Pyrimidine metabolism_Homo sapiens_hsa002400.47163411
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46865406
78Long-term depression_Homo sapiens_hsa047300.45790299
79Metabolic pathways_Homo sapiens_hsa011000.44965983
80RNA degradation_Homo sapiens_hsa030180.44576007
81Synaptic vesicle cycle_Homo sapiens_hsa047210.43126728
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42125835
83Arginine and proline metabolism_Homo sapiens_hsa003300.42001982
84Chemical carcinogenesis_Homo sapiens_hsa052040.41903688
85Circadian entrainment_Homo sapiens_hsa047130.40060772
86Homologous recombination_Homo sapiens_hsa034400.38949281
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38618080
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38378689
89Calcium signaling pathway_Homo sapiens_hsa040200.36910135
90Salivary secretion_Homo sapiens_hsa049700.34993380
91Regulation of autophagy_Homo sapiens_hsa041400.34490191
92Fatty acid degradation_Homo sapiens_hsa000710.33354147
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32212304
94Systemic lupus erythematosus_Homo sapiens_hsa053220.32140955
95Fat digestion and absorption_Homo sapiens_hsa049750.31873013
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31353886
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.31155148
98Leishmaniasis_Homo sapiens_hsa051400.28367074
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27053353
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25986580

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