CLNS1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.62217490
2ribosomal small subunit assembly (GO:0000028)4.87126240
3DNA strand elongation involved in DNA replication (GO:0006271)4.77629052
4DNA replication initiation (GO:0006270)4.65496360
5maturation of SSU-rRNA (GO:0030490)4.61318871
6DNA strand elongation (GO:0022616)4.55989884
7proteasome assembly (GO:0043248)4.47893479
8nucleobase biosynthetic process (GO:0046112)4.47851855
9telomere maintenance via semi-conservative replication (GO:0032201)4.44920005
10purine nucleobase biosynthetic process (GO:0009113)4.37585903
11formation of translation preinitiation complex (GO:0001731)4.32251964
12viral transcription (GO:0019083)4.22784909
13translational termination (GO:0006415)4.22400560
14ribosomal large subunit biogenesis (GO:0042273)4.17697735
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11379907
16DNA replication checkpoint (GO:0000076)4.08590349
17ribosomal small subunit biogenesis (GO:0042274)4.07378331
18ribosome assembly (GO:0042255)4.03644881
19DNA unwinding involved in DNA replication (GO:0006268)4.02338815
20ribonucleoprotein complex biogenesis (GO:0022613)4.00852983
21telomere maintenance via recombination (GO:0000722)3.95644408
22ribosome biogenesis (GO:0042254)3.95364470
23translational elongation (GO:0006414)3.86405914
24CENP-A containing nucleosome assembly (GO:0034080)3.85573786
25synapsis (GO:0007129)3.84460332
26* spliceosomal snRNP assembly (GO:0000387)3.83700127
27IMP biosynthetic process (GO:0006188)3.83690786
28termination of RNA polymerase III transcription (GO:0006386)3.82201602
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.82201602
30translational initiation (GO:0006413)3.79810682
31negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.79109778
32pseudouridine synthesis (GO:0001522)3.77925779
33mitotic metaphase plate congression (GO:0007080)3.76898719
34rRNA processing (GO:0006364)3.75470550
35chromatin remodeling at centromere (GO:0031055)3.74226961
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.73483614
37establishment of integrated proviral latency (GO:0075713)3.71136258
38mitotic recombination (GO:0006312)3.66150829
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65484035
40anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64932331
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.63786028
42rRNA metabolic process (GO:0016072)3.63422834
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.60439993
44cotranslational protein targeting to membrane (GO:0006613)3.58552939
45DNA ligation (GO:0006266)3.57837191
46telomere maintenance via telomere lengthening (GO:0010833)3.57493376
47protein targeting to ER (GO:0045047)3.54597512
48rRNA modification (GO:0000154)3.51516359
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.50459293
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46730632
51negative regulation of ligase activity (GO:0051352)3.46730632
52ATP synthesis coupled proton transport (GO:0015986)3.46209210
53energy coupled proton transport, down electrochemical gradient (GO:0015985)3.46209210
54transcription-coupled nucleotide-excision repair (GO:0006283)3.39819543
55DNA replication-independent nucleosome organization (GO:0034724)3.39685731
56DNA replication-independent nucleosome assembly (GO:0006336)3.39685731
57IMP metabolic process (GO:0046040)3.39551371
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.39369915
597-methylguanosine mRNA capping (GO:0006370)3.39074285
60viral mRNA export from host cell nucleus (GO:0046784)3.38768181
61cellular protein complex disassembly (GO:0043624)3.38065994
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.37601149
63RNA capping (GO:0036260)3.37109392
647-methylguanosine RNA capping (GO:0009452)3.37109392
65protein localization to endoplasmic reticulum (GO:0070972)3.37020091
66establishment of protein localization to endoplasmic reticulum (GO:0072599)3.35028767
67spliceosomal complex assembly (GO:0000245)3.34340490
68translation (GO:0006412)3.33575587
69oxidative phosphorylation (GO:0006119)3.32741401
70DNA replication-dependent nucleosome organization (GO:0034723)3.30062017
71DNA replication-dependent nucleosome assembly (GO:0006335)3.30062017
72viral life cycle (GO:0019058)3.28775485
73cellular component biogenesis (GO:0044085)3.28730370
74regulation of mitochondrial translation (GO:0070129)3.27798505
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27688884
76metaphase plate congression (GO:0051310)3.25985463
77protein localization to kinetochore (GO:0034501)3.25830433
78L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.24578191
79G1/S transition of mitotic cell cycle (GO:0000082)3.23577444
80cell cycle G1/S phase transition (GO:0044843)3.23577444
81cullin deneddylation (GO:0010388)3.23096461
82transcription elongation from RNA polymerase I promoter (GO:0006362)3.21753089
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17969898
84establishment of protein localization to mitochondrial membrane (GO:0090151)3.17879061
85protein deneddylation (GO:0000338)3.16473450
86kinetochore organization (GO:0051383)3.16288705
87nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15426047
88termination of RNA polymerase I transcription (GO:0006363)3.15165937
89mitotic spindle checkpoint (GO:0071174)3.15127113
90non-recombinational repair (GO:0000726)3.15125827
91double-strand break repair via nonhomologous end joining (GO:0006303)3.15125827
92spindle checkpoint (GO:0031577)3.14557349
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14496400
94intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13945946
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13945946
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.12969896
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.12969896
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.12969896
99histone exchange (GO:0043486)3.12865763
100DNA catabolic process, exonucleolytic (GO:0000738)3.11814552
101DNA topological change (GO:0006265)3.11544612
102maturation of 5.8S rRNA (GO:0000460)3.11318155
103mitotic sister chromatid segregation (GO:0000070)3.09379542
104kinetochore assembly (GO:0051382)3.08904390
105mitotic nuclear envelope disassembly (GO:0007077)3.08750541
106melanin biosynthetic process (GO:0042438)3.08520253
107sister chromatid segregation (GO:0000819)3.08301271
108signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07699936
109signal transduction involved in DNA damage checkpoint (GO:0072422)3.07699936
110DNA double-strand break processing (GO:0000729)3.07532679
111negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06690310
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06690310
113negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06690310
114negative regulation of mitotic sister chromatid separation (GO:2000816)3.06690310
115negative regulation of sister chromatid segregation (GO:0033046)3.06690310
116protein complex disassembly (GO:0043241)3.05112621
117signal transduction involved in cell cycle checkpoint (GO:0072395)3.04527543
118regulation of cellular amino acid metabolic process (GO:0006521)3.04314742
119L-serine metabolic process (GO:0006563)3.03474887
120folic acid-containing compound biosynthetic process (GO:0009396)3.02998746
121negative regulation of chromosome segregation (GO:0051985)3.02970865
122establishment of viral latency (GO:0019043)3.01783942
123positive regulation of ligase activity (GO:0051351)3.00996408
124transcription from RNA polymerase I promoter (GO:0006360)2.99801107
125mitotic spindle assembly checkpoint (GO:0007094)2.99267923
126chaperone-mediated protein transport (GO:0072321)2.98922983
127DNA damage response, detection of DNA damage (GO:0042769)2.98694273
128nuclear pore complex assembly (GO:0051292)2.98662245
129histone mRNA metabolic process (GO:0008334)2.97966388
130tRNA aminoacylation for protein translation (GO:0006418)2.97481712
131secondary metabolite biosynthetic process (GO:0044550)2.96832657
132tRNA aminoacylation (GO:0043039)2.96399994
133amino acid activation (GO:0043038)2.96399994
134spindle assembly checkpoint (GO:0071173)2.96326485
135DNA-templated transcription, termination (GO:0006353)2.95695852
136nuclear pore organization (GO:0006999)2.92961570
137inner mitochondrial membrane organization (GO:0007007)2.90890969
138replication fork processing (GO:0031297)2.90389184

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.69976100
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.80677820
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.87589036
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.86214634
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.58101339
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.56130818
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.48303792
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47861426
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.33516801
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.18559950
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.18316670
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.07404799
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99049043
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.94990241
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.94196494
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88180240
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75719493
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64164504
19VDR_23849224_ChIP-Seq_CD4+_Human2.59038221
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58582816
21XRN2_22483619_ChIP-Seq_HELA_Human2.56843946
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43360037
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42592052
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40736136
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33128536
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25013898
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23887234
28* FOXP3_21729870_ChIP-Seq_TREG_Human2.21496712
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.18526258
30DCP1A_22483619_ChIP-Seq_HELA_Human2.16380042
31* GABP_19822575_ChIP-Seq_HepG2_Human2.11955849
32TTF2_22483619_ChIP-Seq_HELA_Human2.11388470
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08509721
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06439657
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98280417
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93496530
37AR_21909140_ChIP-Seq_LNCAP_Human1.93086540
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90444728
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85850049
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.85833092
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85822110
42ELK1_19687146_ChIP-ChIP_HELA_Human1.83985665
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83459891
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.80099175
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79199247
46* E2F1_21310950_ChIP-Seq_MCF-7_Human1.76655200
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73729010
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73397770
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.69868461
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68202215
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66484216
52CIITA_25753668_ChIP-Seq_RAJI_Human1.60829305
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59707534
54FUS_26573619_Chip-Seq_HEK293_Human1.59567211
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48960957
56EWS_26573619_Chip-Seq_HEK293_Human1.46773847
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46249042
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44959379
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41784868
60KDM5A_27292631_Chip-Seq_BREAST_Human1.41559966
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39067732
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37528741
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.33231975
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31691228
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29638888
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28861330
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27732520
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.27563379
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23204880
70VDR_22108803_ChIP-Seq_LS180_Human1.20792218
71IGF1R_20145208_ChIP-Seq_DFB_Human1.20769151
72KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19240348
73* MYC_18940864_ChIP-ChIP_HL60_Human1.16216834
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15986017
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15638528
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15094706
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14420522
78* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14000449
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.12489859
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11033296
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10050592
82ZNF274_21170338_ChIP-Seq_K562_Hela1.07707263
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04019935
84SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03864423
85MYC_22102868_ChIP-Seq_BL_Human1.03418109
86KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02825149
87EGR1_19374776_ChIP-ChIP_THP-1_Human1.00825058
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.00632845
89TFEB_21752829_ChIP-Seq_HELA_Human0.99660504
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99275574
91* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99181367
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98963256
93SOX2_16153702_ChIP-ChIP_HESCs_Human0.96303083
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94742009
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93671946
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91871820
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91486941
98* SPI1_23547873_ChIP-Seq_NB4_Human0.90844342
99* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89246235
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88264569
101* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87109226
102* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84328751
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82699326
104FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81509953
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80454061
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80121412
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75337835
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74742220
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74339824
110TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.73459388
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73335368
112* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73046822
113* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72940580
114TAF15_26573619_Chip-Seq_HEK293_Human0.72587826
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.70979931
116OCT4_18692474_ChIP-Seq_MEFs_Mouse0.70968505
117IRF1_19129219_ChIP-ChIP_H3396_Human0.70331240
118FLI1_27457419_Chip-Seq_LIVER_Mouse0.70283112
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70242213
120ELF5_23300383_ChIP-Seq_T47D_Human0.61511015

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.77430825
2MP0010094_abnormal_chromosome_stability4.80008871
3MP0004957_abnormal_blastocyst_morpholog4.67889171
4MP0003111_abnormal_nucleus_morphology4.37945418
5MP0003077_abnormal_cell_cycle4.05024617
6MP0008058_abnormal_DNA_repair3.91026176
7MP0008057_abnormal_DNA_replication3.81130603
8MP0003136_yellow_coat_color3.26335346
9MP0008007_abnormal_cellular_replicative3.10042377
10MP0008932_abnormal_embryonic_tissue3.00924154
11MP0005408_hypopigmentation2.58779603
12MP0003123_paternal_imprinting2.49098842
13MP0002396_abnormal_hematopoietic_system2.48074414
14MP0005171_absent_coat_pigmentation2.46367304
15MP0003786_premature_aging2.44646422
16MP0006292_abnormal_olfactory_placode2.24199608
17MP0008877_abnormal_DNA_methylation2.18691347
18MP0001730_embryonic_growth_arrest2.12136951
19MP0000350_abnormal_cell_proliferation2.06092150
20MP0009379_abnormal_foot_pigmentation1.99630151
21MP0003718_maternal_effect1.96412483
22MP0003315_abnormal_perineum_morphology1.79599852
23MP0000490_abnormal_crypts_of1.75041167
24* MP0000313_abnormal_cell_death1.52425813
25MP0009333_abnormal_splenocyte_physiolog1.51598362
26MP0001697_abnormal_embryo_size1.51545866
27MP0003121_genomic_imprinting1.47984514
28MP0006072_abnormal_retinal_apoptosis1.45741668
29MP0010030_abnormal_orbit_morphology1.44364028
30* MP0002080_prenatal_lethality1.43653797
31MP0004808_abnormal_hematopoietic_stem1.41649176
32MP0005075_abnormal_melanosome_morpholog1.40928996
33MP0001672_abnormal_embryogenesis/_devel1.37111206
34MP0005380_embryogenesis_phenotype1.37111206
35MP0002019_abnormal_tumor_incidence1.33731933
36MP0002085_abnormal_embryonic_tissue1.30814153
37MP0002102_abnormal_ear_morphology1.30301905
38MP0002210_abnormal_sex_determination1.28269366
39MP0001986_abnormal_taste_sensitivity1.27980106
40MP0001324_abnormal_eye_pigmentation1.26843353
41MP0010307_abnormal_tumor_latency1.25649261
42MP0003763_abnormal_thymus_physiology1.24967511
43MP0001293_anophthalmia1.24426134
44MP0005253_abnormal_eye_physiology1.19674938
45MP0002160_abnormal_reproductive_system1.19063984
46MP0002938_white_spotting1.18353562
47MP0002095_abnormal_skin_pigmentation1.16690352
48MP0001529_abnormal_vocalization1.16579698
49MP0000647_abnormal_sebaceous_gland1.14291740
50MP0003984_embryonic_growth_retardation1.14243909
51MP0002084_abnormal_developmental_patter1.13226680
52MP0002090_abnormal_vision1.11459375
53MP0001188_hyperpigmentation1.10429623
54MP0002088_abnormal_embryonic_growth/wei1.09965819
55MP0001145_abnormal_male_reproductive1.08622303
56MP0003567_abnormal_fetal_cardiomyocyte1.07949238
57MP0000703_abnormal_thymus_morphology1.07303217
58MP0008260_abnormal_autophagy1.01552816
59MP0002398_abnormal_bone_marrow1.01505679
60MP0008789_abnormal_olfactory_epithelium1.00281476
61MP0004133_heterotaxia0.99854577
62MP0000537_abnormal_urethra_morphology0.99523024
63MP0003878_abnormal_ear_physiology0.99507524
64MP0005377_hearing/vestibular/ear_phenot0.99507524
65MP0002722_abnormal_immune_system0.99110458
66MP0002877_abnormal_melanocyte_morpholog0.99005219
67MP0006035_abnormal_mitochondrial_morpho0.97797208
68MP0005389_reproductive_system_phenotype0.97489442
69MP0000358_abnormal_cell_content/0.95528502
70MP0000689_abnormal_spleen_morphology0.95340368
71MP0006036_abnormal_mitochondrial_physio0.92575012
72MP0000653_abnormal_sex_gland0.92218420
73MP0001929_abnormal_gametogenesis0.92088083
74MP0002233_abnormal_nose_morphology0.92066648
75MP0003806_abnormal_nucleotide_metabolis0.90877811
76MP0003186_abnormal_redox_activity0.90813488
77MP0005391_vision/eye_phenotype0.90775130
78MP0003890_abnormal_embryonic-extraembry0.90693801
79MP0002086_abnormal_extraembryonic_tissu0.90117428
80MP0001545_abnormal_hematopoietic_system0.88750676
81MP0005397_hematopoietic_system_phenotyp0.88750676
82MP0003698_abnormal_male_reproductive0.88567983
83MP0002234_abnormal_pharynx_morphology0.88505772
84MP0008995_early_reproductive_senescence0.88370815
85MP0000371_diluted_coat_color0.85214790
86MP0002638_abnormal_pupillary_reflex0.84076784
87MP0004197_abnormal_fetal_growth/weight/0.83127183
88MP0002429_abnormal_blood_cell0.82303061
89MP0002282_abnormal_trachea_morphology0.81947788
90MP0001119_abnormal_female_reproductive0.78255018
91MP0002132_abnormal_respiratory_system0.77828587
92MP0002751_abnormal_autonomic_nervous0.76303124
93MP0003119_abnormal_digestive_system0.75726599
94MP0005394_taste/olfaction_phenotype0.74687504
95MP0005499_abnormal_olfactory_system0.74687504
96MP0010352_gastrointestinal_tract_polyps0.73956853
97MP0000631_abnormal_neuroendocrine_gland0.73163701
98MP0000049_abnormal_middle_ear0.73127726
99MP0002697_abnormal_eye_size0.72767243
100MP0005384_cellular_phenotype0.72723724
101MP0001919_abnormal_reproductive_system0.72513079
102MP0002075_abnormal_coat/hair_pigmentati0.71916360
103MP0003221_abnormal_cardiomyocyte_apopto0.70768480
104MP0005367_renal/urinary_system_phenotyp0.70726198
105MP0000516_abnormal_urinary_system0.70726198
106MP0005551_abnormal_eye_electrophysiolog0.70447072
107MP0005187_abnormal_penis_morphology0.70253473
108MP0006054_spinal_hemorrhage0.69199446
109MP0004147_increased_porphyrin_level0.68985855
110MP0009697_abnormal_copulation0.68921863
111MP0005174_abnormal_tail_pigmentation0.68559650
112MP0003938_abnormal_ear_development0.68149298
113MP0000716_abnormal_immune_system0.68082291
114MP0009672_abnormal_birth_weight0.67635071
115MP0009703_decreased_birth_body0.66617851
116MP0005646_abnormal_pituitary_gland0.66251167
117MP0000015_abnormal_ear_pigmentation0.66221578
118MP0001186_pigmentation_phenotype0.65961858
119MP0002092_abnormal_eye_morphology0.65886366
120MP0002111_abnormal_tail_morphology0.65618722
121MP0003941_abnormal_skin_development0.64951737
122MP0002822_catalepsy0.63668895
123MP0001661_extended_life_span0.63396692
124MP0001764_abnormal_homeostasis0.63221186
125MP0002163_abnormal_gland_morphology0.62573714
126MP0001286_abnormal_eye_development0.61290827
127MP0003937_abnormal_limbs/digits/tail_de0.61283357
128MP0002736_abnormal_nociception_after0.60917740
129MP0000372_irregular_coat_pigmentation0.60133066
130MP0000566_synostosis0.58107109
131MP0001727_abnormal_embryo_implantation0.57098176
132MP0005671_abnormal_response_to0.56438430
133MP0000858_altered_metastatic_potential0.56162376

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.16698311
2Reticulocytopenia (HP:0001896)4.65626779
3Aplastic anemia (HP:0001915)4.19721251
4Abnormality of cells of the erythroid lineage (HP:0012130)4.19449698
5Abnormal number of erythroid precursors (HP:0012131)4.05672854
6Breast hypoplasia (HP:0003187)3.91490652
7Acute encephalopathy (HP:0006846)3.87248139
8Oral leukoplakia (HP:0002745)3.78777992
9Cerebral hypomyelination (HP:0006808)3.74814161
10Rough bone trabeculation (HP:0100670)3.40389020
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.38121123
12Chromsome breakage (HP:0040012)3.37376853
13Lipid accumulation in hepatocytes (HP:0006561)3.32927019
14Macrocytic anemia (HP:0001972)3.29462140
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.29158659
16Abnormality of alanine metabolism (HP:0010916)3.29158659
17Hyperalaninemia (HP:0003348)3.29158659
18Progressive macrocephaly (HP:0004481)3.23063949
19Colon cancer (HP:0003003)3.09315231
20Patellar aplasia (HP:0006443)3.07762136
21Cerebral edema (HP:0002181)3.03990876
22Pallor (HP:0000980)3.02455684
23Microretrognathia (HP:0000308)2.98513842
24Abnormality of the preputium (HP:0100587)2.97302535
25Abnormality of the anterior horn cell (HP:0006802)2.95800158
26Degeneration of anterior horn cells (HP:0002398)2.95800158
27Aplasia/Hypoplasia of the patella (HP:0006498)2.93312256
28Volvulus (HP:0002580)2.86961480
29Hepatic necrosis (HP:0002605)2.86719897
30Premature graying of hair (HP:0002216)2.84531249
31Abnormality of methionine metabolism (HP:0010901)2.84521143
32Meckel diverticulum (HP:0002245)2.83092282
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.79884153
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.79884153
35Type I transferrin isoform profile (HP:0003642)2.77984002
36Abnormality of the ileum (HP:0001549)2.72555641
37Carpal bone hypoplasia (HP:0001498)2.72537673
38Renal Fanconi syndrome (HP:0001994)2.69070129
39Abnormality of serum amino acid levels (HP:0003112)2.68497138
40Abnormality of chromosome stability (HP:0003220)2.66838391
41Medulloblastoma (HP:0002885)2.65189481
42Agnosia (HP:0010524)2.64724604
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.63648742
44Selective tooth agenesis (HP:0001592)2.62105953
45Increased serum lactate (HP:0002151)2.61899202
46Lactic acidosis (HP:0003128)2.57719872
47Hyperglycinemia (HP:0002154)2.56893145
48Secondary amenorrhea (HP:0000869)2.54747560
493-Methylglutaconic aciduria (HP:0003535)2.50854411
50Abnormal trabecular bone morphology (HP:0100671)2.50443852
51CNS hypomyelination (HP:0003429)2.49518217
52Nephroblastoma (Wilms tumor) (HP:0002667)2.48960458
53Pancytopenia (HP:0001876)2.48114139
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.48044137
55Absent thumb (HP:0009777)2.47397424
56Myelodysplasia (HP:0002863)2.46064284
57Increased intramyocellular lipid droplets (HP:0012240)2.44196709
58Bone marrow hypocellularity (HP:0005528)2.43455213
59Type 2 muscle fiber atrophy (HP:0003554)2.43174733
60Muscle fiber atrophy (HP:0100295)2.42470413
61Absent radius (HP:0003974)2.42205712
62Cellular immunodeficiency (HP:0005374)2.39650609
63Embryonal renal neoplasm (HP:0011794)2.37529181
64Hepatocellular necrosis (HP:0001404)2.37296561
65Mitochondrial inheritance (HP:0001427)2.36431887
66Abnormality of the labia minora (HP:0012880)2.35295454
67Triphalangeal thumb (HP:0001199)2.34254211
68Supernumerary spleens (HP:0009799)2.33444230
69Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32583137
70Thrombocytosis (HP:0001894)2.29710091
71Horseshoe kidney (HP:0000085)2.28621259
72Neoplasm of the pancreas (HP:0002894)2.28232613
73Absent forearm bone (HP:0003953)2.27841094
74Aplasia involving forearm bones (HP:0009822)2.27841094
75Multiple enchondromatosis (HP:0005701)2.27499322
76Increased serum pyruvate (HP:0003542)2.26348371
77Abnormality of glycolysis (HP:0004366)2.26348371
78Respiratory difficulties (HP:0002880)2.25721226
79Increased CSF lactate (HP:0002490)2.24543336
80Small intestinal stenosis (HP:0012848)2.24320927
81Duodenal stenosis (HP:0100867)2.24320927
82Methylmalonic acidemia (HP:0002912)2.23620232
83Intestinal atresia (HP:0011100)2.23615840
84Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.23483974
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22128043
86Increased hepatocellular lipid droplets (HP:0006565)2.21755196
87Abnormal lung lobation (HP:0002101)2.19363858
88Gonadotropin excess (HP:0000837)2.18539333
89Leukodystrophy (HP:0002415)2.18279778
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18240261
91Hyperglycinuria (HP:0003108)2.16979600
92IgM deficiency (HP:0002850)2.16944857
93Premature ovarian failure (HP:0008209)2.16621869
94Patchy hypopigmentation of hair (HP:0011365)2.15355142
95Abnormality of glycine metabolism (HP:0010895)2.14828966
96Abnormality of serine family amino acid metabolism (HP:0010894)2.14828966
97Acute necrotizing encephalopathy (HP:0006965)2.13547047
98Facial cleft (HP:0002006)2.11384792
99Exercise intolerance (HP:0003546)2.11143712
10011 pairs of ribs (HP:0000878)2.08676820
101Abnormal number of incisors (HP:0011064)2.08409933
102Median cleft lip (HP:0000161)2.07543518
103Respiratory failure (HP:0002878)2.06695878
104Trismus (HP:0000211)2.05163412
105Impulsivity (HP:0100710)2.03263976
106Poor head control (HP:0002421)2.02554976
107Abnormal mitochondria in muscle tissue (HP:0008316)2.00631640
108Sloping forehead (HP:0000340)1.99797946
109Abnormality of DNA repair (HP:0003254)1.99540307
110Postnatal microcephaly (HP:0005484)1.99434948
111Lethargy (HP:0001254)1.97389230
112Aplasia/Hypoplasia of the fovea (HP:0008060)1.97323933
113Hypoplasia of the fovea (HP:0007750)1.97323933
114Lymphoma (HP:0002665)1.97199880
115Tracheoesophageal fistula (HP:0002575)1.96770567
116Cleft eyelid (HP:0000625)1.95753075
117Ependymoma (HP:0002888)1.95277122
118Reduced antithrombin III activity (HP:0001976)1.94953325
119Increased nuchal translucency (HP:0010880)1.94229167
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92468807
121Abnormal protein N-linked glycosylation (HP:0012347)1.92468807
122Abnormal protein glycosylation (HP:0012346)1.92468807
123Abnormal glycosylation (HP:0012345)1.92468807
124Abnormality of the fovea (HP:0000493)1.91582059
125Bifid tongue (HP:0010297)1.91388484
126Neoplasm of the colon (HP:0100273)1.91364548
127Sparse eyelashes (HP:0000653)1.90800815
128Microvesicular hepatic steatosis (HP:0001414)1.90514036
129Glossoptosis (HP:0000162)1.87496716
130Aplasia/Hypoplasia of the macula (HP:0008059)1.86977572
131Megaloblastic anemia (HP:0001889)1.86731470
132Duplicated collecting system (HP:0000081)1.85911339
133Pulmonary fibrosis (HP:0002206)1.85660965
134Rhabdomyosarcoma (HP:0002859)1.85335179
135Amaurosis fugax (HP:0100576)1.84697896
136Abnormality of the duodenum (HP:0002246)1.84210131
137Optic disc pallor (HP:0000543)1.83592668
138Exertional dyspnea (HP:0002875)1.82856297
139Abnormality of sulfur amino acid metabolism (HP:0004339)1.80894534
140White forelock (HP:0002211)1.79631112
141Increased muscle lipid content (HP:0009058)1.79029718
142CNS demyelination (HP:0007305)1.77434140
143Methylmalonic aciduria (HP:0012120)1.76846175
144Neoplasm of the adrenal gland (HP:0100631)1.73808752
145Abnormal auditory evoked potentials (HP:0006958)1.72040687
146Aplasia/Hypoplasia affecting the retina (HP:0008061)1.71360609
147Abnormality of renal resorption (HP:0011038)1.65790232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.23780667
2WEE14.52200406
3EIF2AK14.17404615
4VRK23.23184026
5STK163.17664058
6CDC73.16905038
7NME22.75592527
8SRPK12.63829470
9EIF2AK32.50416333
10TSSK62.50232786
11VRK12.42777712
12MKNK12.30391591
13ACVR1B2.28630895
14BRSK22.21508916
15PLK42.05938637
16NUAK12.03487279
17TLK11.97199509
18NEK21.95876737
19TESK21.92369687
20TRIM281.89772085
21MKNK21.87174590
22DYRK31.86835075
23PDK21.86335803
24CCNB11.86269394
25PLK11.75135149
26MST41.69290746
27MAP4K21.60156765
28CDK71.59082487
29TTK1.58486002
30BRSK11.56828994
31PLK31.56509492
32NEK11.56354001
33CDK191.50254707
34PASK1.45979010
35ATR1.43962119
36AURKB1.41523656
37CDK81.39782750
38ERBB31.38108890
39MAPKAPK31.34110568
40AURKA1.28659340
41RPS6KB21.22708343
42WNK31.20655847
43SCYL21.19339048
44TAF11.15832799
45RPS6KA41.15303269
46TGFBR11.15209305
47CHEK21.10787530
48BCR1.08788774
49PIM21.06249770
50PLK21.05889400
51ZAK0.98538176
52EIF2AK20.98358724
53TNIK0.98072073
54NME10.94894953
55MAP3K80.90321855
56PAK40.89940791
57DYRK20.85529035
58CHEK10.84761866
59BRAF0.83562685
60DAPK10.83482474
61KDR0.83065336
62CSNK1G20.82299863
63CSNK1A1L0.81447804
64LATS10.77043002
65FLT30.75144595
66STK30.74307601
67CSNK2A10.74183758
68CSNK2A20.73678153
69OXSR10.71003808
70BMPR20.69445062
71CDK40.68261857
72INSRR0.67301958
73STK38L0.67207016
74EPHA20.66367181
75CDK30.63841616
76PAK10.63180632
77STK390.62587077
78MAP3K40.61200893
79MAPKAPK50.59861559
80CDK20.59708526
81PBK0.59619629
82TAOK20.59148494
83RPS6KA50.57343520
84ATM0.56552356
85TEC0.56191592
86PNCK0.54059141
87PIM10.53391838
88MAP2K70.53259042
89STK100.52686308
90STK40.51171721
91BCKDK0.48331729
92MAP3K110.48309173
93CDK60.47358326
94AKT20.46837768
95LIMK10.45471470
96TESK10.45424694
97BTK0.45177873
98CSNK1G30.44857727
99MAP3K120.44481807
100CDK10.44288824
101MAP4K10.43871564
102IRAK40.42935666
103KIT0.42493171
104YES10.41931589
105BRD40.40967725
106FGFR10.40627230
107MAP2K30.39895589
108MST1R0.39412084
109PRKCI0.37096633
110WNK40.36277307
111TXK0.35137958
112AKT30.33735771
113PRKDC0.32516902
114MET0.29670549
115LRRK20.29487834
116CSNK1A10.29229257
117ALK0.28304016
118BMPR1B0.28016519
119CLK10.27772001
120CDK11A0.27725840
121ERBB40.27493725
122MINK10.27200578
123ZAP700.25905163
124LYN0.25211240
125CDK140.24502496
126NEK90.22944464
127CDK180.22847430
128CDK150.20601539
129CSNK1E0.19659472
130MELK0.18861541
131ADRBK20.18140571
132MUSK0.17769697
133ILK0.17584002
134CSNK1G10.17556068
135MAP2K60.17098790

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.84194769
2Ribosome_Homo sapiens_hsa030104.16993518
3Proteasome_Homo sapiens_hsa030504.02919645
4Mismatch repair_Homo sapiens_hsa034303.96914057
5RNA polymerase_Homo sapiens_hsa030203.92242125
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.69351432
7Spliceosome_Homo sapiens_hsa030403.39416164
8Base excision repair_Homo sapiens_hsa034102.98366054
9Homologous recombination_Homo sapiens_hsa034402.90578442
10Nucleotide excision repair_Homo sapiens_hsa034202.90434384
11* RNA transport_Homo sapiens_hsa030132.89469840
12Pyrimidine metabolism_Homo sapiens_hsa002402.84127564
13Cell cycle_Homo sapiens_hsa041102.49161151
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.31057977
15Basal transcription factors_Homo sapiens_hsa030222.25001575
16Fanconi anemia pathway_Homo sapiens_hsa034602.11974618
17One carbon pool by folate_Homo sapiens_hsa006702.10847982
18Non-homologous end-joining_Homo sapiens_hsa034501.95351310
19Propanoate metabolism_Homo sapiens_hsa006401.93857983
20RNA degradation_Homo sapiens_hsa030181.91394564
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77868292
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70117221
23Purine metabolism_Homo sapiens_hsa002301.66844948
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62163022
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55641550
26Pyruvate metabolism_Homo sapiens_hsa006201.54140809
27mRNA surveillance pathway_Homo sapiens_hsa030151.51504121
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44561059
29Fatty acid elongation_Homo sapiens_hsa000621.43281937
30Protein export_Homo sapiens_hsa030601.40343367
31p53 signaling pathway_Homo sapiens_hsa041151.35319003
32Epstein-Barr virus infection_Homo sapiens_hsa051691.22407562
33Parkinsons disease_Homo sapiens_hsa050121.21384013
34Oxidative phosphorylation_Homo sapiens_hsa001901.15135261
35Huntingtons disease_Homo sapiens_hsa050161.11559101
36Vitamin B6 metabolism_Homo sapiens_hsa007501.07249742
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06438199
38Steroid biosynthesis_Homo sapiens_hsa001001.05302364
39Folate biosynthesis_Homo sapiens_hsa007901.04114489
40Systemic lupus erythematosus_Homo sapiens_hsa053220.96483248
41Oocyte meiosis_Homo sapiens_hsa041140.95377082
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86367607
43Butanoate metabolism_Homo sapiens_hsa006500.85107352
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.84536317
45Herpes simplex infection_Homo sapiens_hsa051680.84296844
46Pentose phosphate pathway_Homo sapiens_hsa000300.77012084
47Peroxisome_Homo sapiens_hsa041460.75057581
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71718039
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71572567
50Viral carcinogenesis_Homo sapiens_hsa052030.71379409
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69998474
52Antigen processing and presentation_Homo sapiens_hsa046120.69242228
53Fatty acid metabolism_Homo sapiens_hsa012120.66778366
54Sulfur relay system_Homo sapiens_hsa041220.64809229
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63758724
56Biosynthesis of amino acids_Homo sapiens_hsa012300.61266126
57Tyrosine metabolism_Homo sapiens_hsa003500.54797857
58N-Glycan biosynthesis_Homo sapiens_hsa005100.54187055
59beta-Alanine metabolism_Homo sapiens_hsa004100.53238526
60Alzheimers disease_Homo sapiens_hsa050100.52576315
61Fatty acid degradation_Homo sapiens_hsa000710.52275381
62Cardiac muscle contraction_Homo sapiens_hsa042600.51732496
63Alcoholism_Homo sapiens_hsa050340.51039693
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.50757616
65HTLV-I infection_Homo sapiens_hsa051660.50322381
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.50094590
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50067917
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50012085
69Regulation of autophagy_Homo sapiens_hsa041400.48705560
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47842130
71Legionellosis_Homo sapiens_hsa051340.46057764
72Thyroid cancer_Homo sapiens_hsa052160.45966515
73Primary immunodeficiency_Homo sapiens_hsa053400.45949613
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45695334
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44909891
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44641956
77Arginine and proline metabolism_Homo sapiens_hsa003300.44592942
78Nitrogen metabolism_Homo sapiens_hsa009100.43673611
79Tryptophan metabolism_Homo sapiens_hsa003800.43433773
80Glutathione metabolism_Homo sapiens_hsa004800.43107278
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41904967
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39375557
83Fructose and mannose metabolism_Homo sapiens_hsa000510.37595096
84Selenocompound metabolism_Homo sapiens_hsa004500.35768327
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35693107
86Metabolic pathways_Homo sapiens_hsa011000.35360698
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32229418
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30427529
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30361784
90Shigellosis_Homo sapiens_hsa051310.30245183
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29594538
92Measles_Homo sapiens_hsa051620.28960489
93Lysine degradation_Homo sapiens_hsa003100.28584651
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28331303
95Apoptosis_Homo sapiens_hsa042100.28230886
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26724408
97Sulfur metabolism_Homo sapiens_hsa009200.26701648
98Chemical carcinogenesis_Homo sapiens_hsa052040.25921757
99Arachidonic acid metabolism_Homo sapiens_hsa005900.25865857
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.23598993
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23094009
102Carbon metabolism_Homo sapiens_hsa012000.21858610
103Hematopoietic cell lineage_Homo sapiens_hsa046400.20671433
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19469470
105Hepatitis B_Homo sapiens_hsa051610.16801126
106MicroRNAs in cancer_Homo sapiens_hsa052060.16776525
107Colorectal cancer_Homo sapiens_hsa052100.15373857
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15209745
109Small cell lung cancer_Homo sapiens_hsa052220.14903572
110Asthma_Homo sapiens_hsa053100.14901653
111Arginine biosynthesis_Homo sapiens_hsa002200.14591414
112Galactose metabolism_Homo sapiens_hsa000520.14168363
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14081813
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13112778
115Phototransduction_Homo sapiens_hsa047440.13039511
116Basal cell carcinoma_Homo sapiens_hsa052170.12136951
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12018101
118Retinol metabolism_Homo sapiens_hsa008300.11510778
119Caffeine metabolism_Homo sapiens_hsa002320.11297385
120Vitamin digestion and absorption_Homo sapiens_hsa049770.10918859
121Hippo signaling pathway_Homo sapiens_hsa043900.10810676
122Influenza A_Homo sapiens_hsa051640.10339849
123Olfactory transduction_Homo sapiens_hsa047400.08637318
124TGF-beta signaling pathway_Homo sapiens_hsa043500.08242296
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.08226816
126Allograft rejection_Homo sapiens_hsa053300.07930883
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.07430305
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06957362
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.06736491
130Pathways in cancer_Homo sapiens_hsa052000.06732009
131Hedgehog signaling pathway_Homo sapiens_hsa043400.06336826
132Notch signaling pathway_Homo sapiens_hsa043300.05969838
133Wnt signaling pathway_Homo sapiens_hsa043100.04844855
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.04555779
135HIF-1 signaling pathway_Homo sapiens_hsa040660.02492850

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