CLMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endodermal cell differentiation (GO:0035987)5.32437457
2hemidesmosome assembly (GO:0031581)4.93425282
3metanephric mesenchyme development (GO:0072075)4.81314519
4kidney mesenchyme development (GO:0072074)4.59687241
5type B pancreatic cell proliferation (GO:0044342)4.57208779
6cell migration involved in heart development (GO:0060973)4.55174588
7regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.53619000
8skin morphogenesis (GO:0043589)4.45855343
9extracellular matrix assembly (GO:0085029)4.39378285
10protein heterotrimerization (GO:0070208)4.37132241
11cellular response to vitamin (GO:0071295)4.25002529
12cell adhesion mediated by integrin (GO:0033627)4.19968799
13cell migration in hindbrain (GO:0021535)4.16244544
14negative regulation of smooth muscle cell migration (GO:0014912)4.14840450
15pyrimidine nucleobase catabolic process (GO:0006208)4.14670380
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.12298188
17chondrocyte proliferation (GO:0035988)4.08952597
18collagen fibril organization (GO:0030199)4.04753942
19neuron recognition (GO:0008038)3.99188732
20axonal fasciculation (GO:0007413)3.98570808
21mesenchymal-epithelial cell signaling (GO:0060638)3.91096474
22vocalization behavior (GO:0071625)3.78677109
23layer formation in cerebral cortex (GO:0021819)3.77291987
24axon extension involved in axon guidance (GO:0048846)3.76970590
25neuron projection extension involved in neuron projection guidance (GO:1902284)3.76970590
26axon extension (GO:0048675)3.76867419
27substrate-dependent cell migration (GO:0006929)3.76709702
28bone trabecula formation (GO:0060346)3.76434743
29central nervous system projection neuron axonogenesis (GO:0021952)3.76425738
30retina vasculature morphogenesis in camera-type eye (GO:0061299)3.75647492
31cell-substrate junction assembly (GO:0007044)3.75397726
32dendritic spine morphogenesis (GO:0060997)3.73945907
33endothelial cell morphogenesis (GO:0001886)3.68868343
34protein localization to cell surface (GO:0034394)3.68431519
35negative regulation of microtubule polymerization (GO:0031115)3.68380482
36fibril organization (GO:0097435)3.58707779
37neuron cell-cell adhesion (GO:0007158)3.57031081
38cell migration involved in sprouting angiogenesis (GO:0002042)3.56397498
39vascular endothelial growth factor signaling pathway (GO:0038084)3.54759988
40sequestering of extracellular ligand from receptor (GO:0035581)3.52680690
41negative regulation of BMP signaling pathway (GO:0030514)3.51705395
42nucleobase catabolic process (GO:0046113)3.49872455
43negative regulation of fatty acid transport (GO:2000192)3.46714037
44chondrocyte development (GO:0002063)3.46433732
45heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.44249447
46dendrite morphogenesis (GO:0048813)3.42658046
47cellular response to vitamin D (GO:0071305)3.39384480
48virion attachment to host cell (GO:0019062)3.33287458
49adhesion of symbiont to host cell (GO:0044650)3.33287458
50positive regulation of blood vessel endothelial cell migration (GO:0043536)3.32230688
51positive regulation of synapse assembly (GO:0051965)3.31598794
52substrate adhesion-dependent cell spreading (GO:0034446)3.31237743
53extracellular matrix disassembly (GO:0022617)3.29391559
54negative regulation of catenin import into nucleus (GO:0035414)3.29262414
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.27866358
56regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.25567154
57negative regulation of chondrocyte differentiation (GO:0032331)3.25456843
58dermatan sulfate biosynthetic process (GO:0030208)3.24869113
59positive regulation of endothelial cell apoptotic process (GO:2000353)3.24496137
60apoptotic cell clearance (GO:0043277)3.22643928
61neuron projection extension (GO:1990138)3.22504304
62low-density lipoprotein particle clearance (GO:0034383)3.18276559
63blood vessel maturation (GO:0001955)3.17478413
64planar cell polarity pathway involved in neural tube closure (GO:0090179)3.12446608
65regulation of integrin-mediated signaling pathway (GO:2001044)3.12123290
66positive regulation of fibroblast migration (GO:0010763)3.10549803
67protein retention in ER lumen (GO:0006621)3.08889186
68extracellular matrix organization (GO:0030198)3.08278279
69barbed-end actin filament capping (GO:0051016)3.07912160
70extracellular structure organization (GO:0043062)3.07082762
71proximal/distal pattern formation (GO:0009954)3.07010167
72regulation of plasminogen activation (GO:0010755)3.06198861
73outer ear morphogenesis (GO:0042473)3.05384452
74glial cell migration (GO:0008347)3.04858056
75basement membrane organization (GO:0071711)3.04297129
76central nervous system neuron axonogenesis (GO:0021955)3.03253868
77smooth muscle tissue development (GO:0048745)3.02859419
78protein localization to synapse (GO:0035418)3.02554901
79peptidyl-proline hydroxylation (GO:0019511)2.98835972
80maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98706738
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.97323375
82negative regulation of nitric-oxide synthase activity (GO:0051001)2.96890557
83limb bud formation (GO:0060174)2.94634419
84positive regulation of axon extension (GO:0045773)2.93384504
85glomerular basement membrane development (GO:0032836)2.91860877
86negative chemotaxis (GO:0050919)2.91613482
87mesodermal cell differentiation (GO:0048333)2.91074714
88regulation of axon guidance (GO:1902667)2.89624973
89paraxial mesoderm development (GO:0048339)2.88984620
90regulation of extracellular matrix disassembly (GO:0010715)2.88844370
91neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.88728991
92regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88724087
93adhesion of symbiont to host (GO:0044406)2.88617640
94regulation of axon extension involved in axon guidance (GO:0048841)2.88490922
95negative regulation of osteoblast proliferation (GO:0033689)2.88275545
96exploration behavior (GO:0035640)2.88214108
97keratan sulfate catabolic process (GO:0042340)2.87765198
98endocardial cushion development (GO:0003197)2.87671891
99negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.87025585
100protein hydroxylation (GO:0018126)2.86081842
101craniofacial suture morphogenesis (GO:0097094)2.85659299
102negative regulation of cartilage development (GO:0061037)2.83691756
103dermatan sulfate metabolic process (GO:0030205)2.82350448
104lymphangiogenesis (GO:0001946)2.81279998
105regulation of synapse assembly (GO:0051963)2.80479393
106negative regulation of axon guidance (GO:1902668)2.80384759
107wound healing, spreading of epidermal cells (GO:0035313)2.79688372
108middle ear morphogenesis (GO:0042474)2.79465677
109dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.77209388
110muscle cell migration (GO:0014812)2.77170416
111regulation of glutamate receptor signaling pathway (GO:1900449)2.76508047
112pericardium development (GO:0060039)2.76496096
113negative regulation of axon extension involved in axon guidance (GO:0048843)2.76441293
114positive regulation of osteoblast proliferation (GO:0033690)2.76214895
115positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.76214300
116postsynaptic membrane organization (GO:0001941)2.73908578
117regulation of smooth muscle cell migration (GO:0014910)2.73599309
118collagen catabolic process (GO:0030574)2.73138192
119lateral sprouting from an epithelium (GO:0060601)2.73019716
120L-serine transport (GO:0015825)2.72626229
121embryonic forelimb morphogenesis (GO:0035115)2.72361674
122embryonic skeletal joint morphogenesis (GO:0060272)2.72271482
123short-term memory (GO:0007614)2.70588994
124collagen metabolic process (GO:0032963)2.68153330
125extracellular fibril organization (GO:0043206)2.67477722
126endocrine hormone secretion (GO:0060986)2.65937265
127sprouting angiogenesis (GO:0002040)2.65760496
128head development (GO:0060322)2.64741118
129extracellular regulation of signal transduction (GO:1900115)2.62875325
130extracellular negative regulation of signal transduction (GO:1900116)2.62875325
131stress fiber assembly (GO:0043149)2.62268506
132regulation of osteoblast proliferation (GO:0033688)2.61824834
133regulation of non-canonical Wnt signaling pathway (GO:2000050)2.60500757
134cellular response to amino acid stimulus (GO:0071230)2.59996755
135regulation of axon extension (GO:0030516)2.59450940
136innervation (GO:0060384)2.58778107
137vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.58492378
138proline transport (GO:0015824)2.56272014
139multicellular organismal macromolecule metabolic process (GO:0044259)2.55631392
140embryonic cranial skeleton morphogenesis (GO:0048701)2.54773988
141ganglion development (GO:0061548)2.54718860
142regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.50740666
143eyelid development in camera-type eye (GO:0061029)2.48904119
144dopaminergic neuron differentiation (GO:0071542)2.48248253
145positive regulation of gastrulation (GO:2000543)2.47978207
146synaptic vesicle exocytosis (GO:0016079)2.47974415
147forelimb morphogenesis (GO:0035136)2.47426895
148body morphogenesis (GO:0010171)2.46995184
149regulation of neuron migration (GO:2001222)2.46455947
150developmental cell growth (GO:0048588)2.45859417
151cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.45544993
152regulation of synapse organization (GO:0050807)2.45380830
153cranial nerve morphogenesis (GO:0021602)2.44351759
154camera-type eye morphogenesis (GO:0048593)2.43927272
155multicellular organismal catabolic process (GO:0044243)2.43826458
156ionotropic glutamate receptor signaling pathway (GO:0035235)2.43368864
157locomotory exploration behavior (GO:0035641)2.43127090
158regulation of short-term neuronal synaptic plasticity (GO:0048172)2.42711853
159sympathetic nervous system development (GO:0048485)2.42395626
160inner ear receptor cell development (GO:0060119)2.41820765
161G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.40532611
162peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.39327272
163multicellular organismal metabolic process (GO:0044236)2.38918370
164synaptic vesicle maturation (GO:0016188)2.38791074
165negative regulation of axon extension (GO:0030517)2.37586591
166positive regulation of synapse maturation (GO:0090129)2.36991281
167positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.36212934
168heparan sulfate proteoglycan metabolic process (GO:0030201)2.34166756
169gamma-aminobutyric acid transport (GO:0015812)2.33590451
170plasma membrane repair (GO:0001778)2.32671164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.18175026
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.90262305
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.16201527
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11802385
5* BRD4_25478319_ChIP-Seq_HGPS_Human3.11263973
6EZH2_27304074_Chip-Seq_ESCs_Mouse3.05955994
7EED_16625203_ChIP-ChIP_MESCs_Mouse3.00203387
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.95642698
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.95642698
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94561579
11GBX2_23144817_ChIP-Seq_PC3_Human2.90422812
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87251935
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.80755111
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77181626
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.75469378
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69733342
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.62274506
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.59198442
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.54751748
20CLOCK_20551151_ChIP-Seq_293T_Human2.50151494
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47108260
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.41165293
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.38135597
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.36281022
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.26838753
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.22528542
27CBX2_27304074_Chip-Seq_ESCs_Mouse2.16247449
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15563877
29MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14587970
30AR_21572438_ChIP-Seq_LNCaP_Human2.08427729
31RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.08312202
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05573126
33EZH2_27294783_Chip-Seq_ESCs_Mouse2.05186716
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97242210
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95623574
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95393402
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94210959
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93157071
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87144791
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85243056
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82675725
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.82070610
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79710595
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78971539
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72627357
46SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71341927
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71341927
48ZNF274_21170338_ChIP-Seq_K562_Hela1.63729118
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61856430
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.60049751
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59437944
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.58703823
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57403313
54JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57105084
55JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56910439
56RING1B_27294783_Chip-Seq_NPCs_Mouse1.53552463
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.52703617
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.52408504
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51850957
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51554616
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50659956
62RNF2_27304074_Chip-Seq_NSC_Mouse1.50557899
63TP53_18474530_ChIP-ChIP_U2OS_Human1.49313232
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48440980
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47890582
66DROSHA_22980978_ChIP-Seq_HELA_Human1.44922476
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.43800792
68SA1_22415368_ChIP-Seq_MEFs_Mouse1.42741888
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.42486025
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42390184
71UBF1/2_26484160_Chip-Seq_HMECs_Human1.39927574
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39434878
73P300_19829295_ChIP-Seq_ESCs_Human1.39186529
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38864554
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37563150
76SMC1_22415368_ChIP-Seq_MEFs_Mouse1.36469071
77SMAD4_21799915_ChIP-Seq_A2780_Human1.35850228
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.33475124
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.33475124
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32990011
81REST_21632747_ChIP-Seq_MESCs_Mouse1.32131476
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30949348
83IGF1R_20145208_ChIP-Seq_DFB_Human1.30626687
84ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29503474
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29189324
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28824455
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.28158928
88CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28071936
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27201344
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26687489
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25840076
92EP300_21415370_ChIP-Seq_HL-1_Mouse1.24837030
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24441980
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.23534218
95FUS_26573619_Chip-Seq_HEK293_Human1.23378601
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.22509677
97MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22478034
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.21914087
99TAF15_26573619_Chip-Seq_HEK293_Human1.21511317
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21162709
101TP53_22127205_ChIP-Seq_IMR90_Human1.20675861
102PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.18925522
103TBX20_22328084_ChIP-Seq_HEART_Mouse1.17156565
104TBX20_22080862_ChIP-Seq_HEART_Mouse1.17156565
105POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15854593
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15378623
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15000365
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14822381
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14054711
110AR_25329375_ChIP-Seq_VCAP_Human1.12705917
111SALL1_21062744_ChIP-ChIP_HESCs_Human1.12194923
112ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11021987
113TP53_23651856_ChIP-Seq_MEFs_Mouse1.10635401
114BP1_19119308_ChIP-ChIP_Hs578T_Human1.10064535
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.09060138
116ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07824468
117CJUN_26792858_Chip-Seq_BT549_Human1.06747568
118SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06500441
119NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05672545
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04216641
121AHR_22903824_ChIP-Seq_MCF-7_Human1.03530394
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03456681
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.03307418
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03271753
125YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03217966
126RUNX2_22187159_ChIP-Seq_PCA_Human1.03152784
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02318328
128ER_23166858_ChIP-Seq_MCF-7_Human1.02025292
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01493403
130ISL1_27105846_Chip-Seq_CPCs_Mouse1.00543456
131JUN_21703547_ChIP-Seq_K562_Human1.00401432
132TP63_19390658_ChIP-ChIP_HaCaT_Human0.99682645
133SOX2_20726797_ChIP-Seq_SW620_Human0.99328325
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98948252
135TP63_23658742_ChIP-Seq_EP156T_Human0.98746173
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98195854
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97972749
138GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97559686
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97402779
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97194263
141TP53_16413492_ChIP-PET_HCT116_Human0.96497541
142AR_19668381_ChIP-Seq_PC3_Human0.95892166
143TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95670666
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95053429
145TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94858088
146P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94302190
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93769825
148SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92699392
149ESR2_21235772_ChIP-Seq_MCF-7_Human0.92470710
150CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90915647
151ZNF263_19887448_ChIP-Seq_K562_Human0.90471278
152PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.90283301
153FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.87401861
154* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86567016
155NFI_21473784_ChIP-Seq_ESCs_Mouse0.85829376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.23645633
2MP0005503_abnormal_tendon_morphology4.34056580
3MP0005275_abnormal_skin_tensile3.12545283
4MP0009384_cardiac_valve_regurgitation2.65797022
5MP0000569_abnormal_digit_pigmentation2.64666951
6MP0003950_abnormal_plasma_membrane2.63907864
7MP0006054_spinal_hemorrhage2.50053656
8MP0003385_abnormal_body_wall2.49679404
9MP0009250_abnormal_appendicular_skeleto2.39591384
10MP0003566_abnormal_cell_adhesion2.38977706
11MP0004859_abnormal_synaptic_plasticity2.33079750
12MP0003880_abnormal_central_pattern2.32658367
13MP0003122_maternal_imprinting2.27188559
14MP0000778_abnormal_nervous_system2.19860434
15MP0009379_abnormal_foot_pigmentation2.17267417
16MP0002060_abnormal_skin_morphology2.15858609
17MP0010368_abnormal_lymphatic_system2.05647733
18MP0006276_abnormal_autonomic_nervous2.02234877
19MP0003941_abnormal_skin_development2.00296509
20MP0001299_abnormal_eye_distance/1.92874240
21MP0005023_abnormal_wound_healing1.89984597
22MP0003942_abnormal_urinary_system1.88287478
23MP0001958_emphysema1.86865371
24MP0005257_abnormal_intraocular_pressure1.86296456
25MP0003635_abnormal_synaptic_transmissio1.77974635
26MP0000767_abnormal_smooth_muscle1.77895111
27MP0010030_abnormal_orbit_morphology1.75692469
28MP0009053_abnormal_anal_canal1.73213557
29MP0003705_abnormal_hypodermis_morpholog1.69084177
30MP0002184_abnormal_innervation1.68591190
31MP0005623_abnormal_meninges_morphology1.67552661
32MP0000534_abnormal_ureter_morphology1.67467381
33MP0000049_abnormal_middle_ear1.66595634
34MP0005508_abnormal_skeleton_morphology1.65630832
35MP0004270_analgesia1.63973828
36MP0004272_abnormal_basement_membrane1.63391400
37MP0000013_abnormal_adipose_tissue1.60749819
38MP0002282_abnormal_trachea_morphology1.58604061
39MP0003279_aneurysm1.56739800
40MP0003755_abnormal_palate_morphology1.55707415
41MP0002938_white_spotting1.51311457
42MP0002734_abnormal_mechanical_nocicepti1.50093633
43MP0002063_abnormal_learning/memory/cond1.46942148
44MP0000537_abnormal_urethra_morphology1.46064624
45MP0000751_myopathy1.45963289
46MP0005595_abnormal_vascular_smooth1.44960470
47MP0010352_gastrointestinal_tract_polyps1.44468923
48MP0002102_abnormal_ear_morphology1.44092388
49MP0005423_abnormal_somatic_nervous1.43373142
50MP0005670_abnormal_white_adipose1.42626203
51MP0004858_abnormal_nervous_system1.40442082
52MP0001243_abnormal_dermal_layer1.39075370
53MP0005248_abnormal_Harderian_gland1.32334889
54MP0001968_abnormal_touch/_nociception1.31476946
55MP0005367_renal/urinary_system_phenotyp1.31187119
56MP0000516_abnormal_urinary_system1.31187119
57MP0002108_abnormal_muscle_morphology1.28159902
58MP0000003_abnormal_adipose_tissue1.27688463
59MP0002735_abnormal_chemical_nociception1.27423621
60MP0002116_abnormal_craniofacial_bone1.26526329
61MP0005187_abnormal_penis_morphology1.25888981
62MP0002896_abnormal_bone_mineralization1.25189570
63MP0002115_abnormal_skeleton_extremities1.16555309
64MP0009046_muscle_twitch1.14928535
65MP0002572_abnormal_emotion/affect_behav1.14801935
66MP0002932_abnormal_joint_morphology1.14798613
67MP0001188_hyperpigmentation1.12254694
68MP0003938_abnormal_ear_development1.12039909
69MP0003937_abnormal_limbs/digits/tail_de1.11312941
70MP0000955_abnormal_spinal_cord1.11128810
71MP0005375_adipose_tissue_phenotype1.08192392
72MP0004134_abnormal_chest_morphology1.07872304
73MP0009745_abnormal_behavioral_response1.07835021
74MP0000163_abnormal_cartilage_morphology1.06379563
75MP0000428_abnormal_craniofacial_morphol1.06013414
76MP0002733_abnormal_thermal_nociception1.05624136
77MP0002177_abnormal_outer_ear1.04223749
78MP0004811_abnormal_neuron_physiology1.03926768
79MP0002233_abnormal_nose_morphology1.02357423
80MP0003123_paternal_imprinting1.00965843
81MP0000733_abnormal_muscle_development0.99627951
82MP0003121_genomic_imprinting0.98833430
83MP0002295_abnormal_pulmonary_circulatio0.98374446
84MP0001879_abnormal_lymphatic_vessel0.98370064
85MP0002109_abnormal_limb_morphology0.97867510
86MP0001849_ear_inflammation0.97359995
87MP0003935_abnormal_craniofacial_develop0.97274744
88MP0002557_abnormal_social/conspecific_i0.97104915
89MP0002064_seizures0.96706106
90MP0002249_abnormal_larynx_morphology0.95792739
91MP0001970_abnormal_pain_threshold0.95506598
92MP0001440_abnormal_grooming_behavior0.95419205
93MP0002971_abnormal_brown_adipose0.94094433
94MP0000759_abnormal_skeletal_muscle0.93920896
95MP0003861_abnormal_nervous_system0.93816522
96MP0001486_abnormal_startle_reflex0.93565842
97MP0001542_abnormal_bone_strength0.93449035
98MP0003283_abnormal_digestive_organ0.93239590
99MP0002736_abnormal_nociception_after0.92903935
100MP0005164_abnormal_response_to0.92205132
101MP0002113_abnormal_skeleton_development0.90920391
102MP0005666_abnormal_adipose_tissue0.90549843
103MP0000538_abnormal_urinary_bladder0.89974090
104MP0003091_abnormal_cell_migration0.89376508
105MP0005390_skeleton_phenotype0.89265975
106MP0005171_absent_coat_pigmentation0.88777097
107MP0001177_atelectasis0.88140798
108MP0002114_abnormal_axial_skeleton0.85774788
109MP0003315_abnormal_perineum_morphology0.85735163
110MP0002067_abnormal_sensory_capabilities0.85369808
111MP0010386_abnormal_urinary_bladder0.84800646
112MP0000467_abnormal_esophagus_morphology0.84800608
113MP0003115_abnormal_respiratory_system0.84760138
114MP0000432_abnormal_head_morphology0.84748070
115MP0000749_muscle_degeneration0.84568583
116MP0002877_abnormal_melanocyte_morpholog0.83445729
117MP0006138_congestive_heart_failure0.82632578
118MP0002152_abnormal_brain_morphology0.82136747
119MP0002882_abnormal_neuron_morphology0.81199070
120MP0001501_abnormal_sleep_pattern0.81177860
121MP0004130_abnormal_muscle_cell0.80695411
122MP0002751_abnormal_autonomic_nervous0.80690592
123MP0005386_behavior/neurological_phenoty0.80061304
124MP0004924_abnormal_behavior0.80061304
125MP0002081_perinatal_lethality0.78713510
126MP0000762_abnormal_tongue_morphology0.78591763
127MP0001348_abnormal_lacrimal_gland0.78044207
128MP0004883_abnormal_blood_vessel0.75431636
129MP0009780_abnormal_chondrocyte_physiolo0.75417092
130MP0002133_abnormal_respiratory_system0.75400111
131MP0005388_respiratory_system_phenotype0.75400111
132MP0002128_abnormal_blood_circulation0.74416518
133MP0005197_abnormal_uvea_morphology0.73364505
134MP0003448_altered_tumor_morphology0.71853512
135MP0003828_pulmonary_edema0.69644958
136MP0001661_extended_life_span0.69555614
137MP0001614_abnormal_blood_vessel0.68520468
138MP0003959_abnormal_lean_body0.68285944
139MP0004185_abnormal_adipocyte_glucose0.66711269
140MP0000462_abnormal_digestive_system0.63768222
141MP0002254_reproductive_system_inflammat0.61419833
142MP0002168_other_aberrant_phenotype0.60797274
143MP0004084_abnormal_cardiac_muscle0.60743638
144MP0000579_abnormal_nail_morphology0.59679377
145MP0010771_integument_phenotype0.59604596
146MP0000750_abnormal_muscle_regeneration0.58565495
147MP0003191_abnormal_cellular_cholesterol0.58418320
148MP0002933_joint_inflammation0.57654634
149MP0005165_increased_susceptibility_to0.57160714
150MP0001175_abnormal_lung_morphology0.56168735
151MP0003868_abnormal_feces_composition0.55755889
152MP0005193_abnormal_anterior_eye0.54258076

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.23789038
2Premature rupture of membranes (HP:0001788)4.92617656
3Shallow orbits (HP:0000586)4.06236131
4Soft skin (HP:0000977)3.48791228
5Wrist flexion contracture (HP:0001239)3.25136765
6Follicular hyperkeratosis (HP:0007502)3.15468214
7Overgrowth (HP:0001548)3.14982540
8Spondylolisthesis (HP:0003302)3.06589994
9Short 4th metacarpal (HP:0010044)3.04556172
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.04556172
11Bladder diverticulum (HP:0000015)3.00302109
12Osteolytic defects of the hand bones (HP:0009699)2.95913671
13Osteolytic defects of the phalanges of the hand (HP:0009771)2.95913671
14Ankle contracture (HP:0006466)2.95392085
15Aortic dissection (HP:0002647)2.93494827
16Broad metatarsal (HP:0001783)2.81187275
17Aortic regurgitation (HP:0001659)2.73565096
18Neonatal short-limb short stature (HP:0008921)2.71897873
19Hypoventilation (HP:0002791)2.71321990
20Genu recurvatum (HP:0002816)2.61421711
21Buphthalmos (HP:0000557)2.53979598
22Morphological abnormality of the middle ear (HP:0008609)2.52552563
23Asymmetry of the thorax (HP:0001555)2.52437355
24Hyperextensible skin (HP:0000974)2.52052004
25Abnormality of the 4th metacarpal (HP:0010012)2.50414280
26Abnormality of skeletal muscle fiber size (HP:0012084)2.47343360
27Abnormality of dentin (HP:0010299)2.45492539
28Wide anterior fontanel (HP:0000260)2.44674433
29Abnormal delivery (HP:0001787)2.40670637
30Abnormality of the acetabulum (HP:0003170)2.40613001
31Mitral regurgitation (HP:0001653)2.39347235
32Coronal craniosynostosis (HP:0004440)2.35766727
33Aortic valve stenosis (HP:0001650)2.35030447
34Atrophic scars (HP:0001075)2.33770560
35Peritonitis (HP:0002586)2.33668612
36Wormian bones (HP:0002645)2.32631296
37Microglossia (HP:0000171)2.30037502
38Cardiovascular calcification (HP:0011915)2.28719853
39Dilatation of the ascending aorta (HP:0005111)2.27686060
40Fragile skin (HP:0001030)2.26632317
41Mitral valve prolapse (HP:0001634)2.26547792
42Type 1 muscle fiber predominance (HP:0003803)2.23907493
43Vertebral compression fractures (HP:0002953)2.23843778
44Ectopia lentis (HP:0001083)2.22287463
45Aneurysm (HP:0002617)2.21639338
46Delayed cranial suture closure (HP:0000270)2.21284959
47Delayed closure of the anterior fontanelle (HP:0001476)2.21188583
48Narrow nasal bridge (HP:0000446)2.20684950
49Mitral stenosis (HP:0001718)2.18394931
50Natal tooth (HP:0000695)2.18393133
51Increased connective tissue (HP:0009025)2.14102177
52Cerebral aneurysm (HP:0004944)2.13996109
53Spinal rigidity (HP:0003306)2.13193527
54Deviation of the hallux (HP:0010051)2.12897307
55Joint stiffness (HP:0001387)2.12171159
56Focal seizures (HP:0007359)2.11515390
57Short nail (HP:0001799)2.11205195
58Slender build (HP:0001533)2.09267914
59Aortic aneurysm (HP:0004942)2.09175143
60Renal duplication (HP:0000075)2.07686423
61Hepatoblastoma (HP:0002884)2.06577394
62Generalized amyotrophy (HP:0003700)2.05540289
63Broad ribs (HP:0000885)2.03247018
64Limb dystonia (HP:0002451)2.01557254
65Mutism (HP:0002300)2.01449279
66Joint laxity (HP:0001388)1.98669071
67Myokymia (HP:0002411)1.98409724
68Disproportionate tall stature (HP:0001519)1.98036029
69Bowel diverticulosis (HP:0005222)1.97160998
70Cervical subluxation (HP:0003308)1.96252507
71Ulnar bowing (HP:0003031)1.96208338
72Knee flexion contracture (HP:0006380)1.96191302
73Shoulder girdle muscle weakness (HP:0003547)1.95706107
74Mildly elevated creatine phosphokinase (HP:0008180)1.95519489
75Reduced subcutaneous adipose tissue (HP:0003758)1.94514297
76Abnormality of the parietal bone (HP:0002696)1.94417469
77Ovoid vertebral bodies (HP:0003300)1.93989768
78Breech presentation (HP:0001623)1.93970942
79Biconcave vertebral bodies (HP:0004586)1.93424511
80Round ear (HP:0100830)1.93334007
81Hallux valgus (HP:0001822)1.92929595
82Spinal cord compression (HP:0002176)1.92750052
83Mild short stature (HP:0003502)1.92392464
84Infantile muscular hypotonia (HP:0008947)1.92136405
85Bronchomalacia (HP:0002780)1.92010766
86Redundant skin (HP:0001582)1.91895421
87Limb-girdle muscle weakness (HP:0003325)1.91721766
88Abnormality of the phalanges of the hallux (HP:0010057)1.88998021
89Aplasia involving bones of the extremities (HP:0009825)1.88630962
90Aplasia involving bones of the upper limbs (HP:0009823)1.88630962
91Aplasia of the phalanges of the hand (HP:0009802)1.88630962
92Camptodactyly of toe (HP:0001836)1.88626776
93Blue sclerae (HP:0000592)1.88206544
94Concave nail (HP:0001598)1.86196706
95Osteoarthritis (HP:0002758)1.85831013
96Abnormality of carpal bone ossification (HP:0006257)1.85572766
97Midline defect of the nose (HP:0004122)1.85440058
98Mesomelia (HP:0003027)1.83516297
99Venous abnormality (HP:0002624)1.83054457
100Flared iliac wings (HP:0002869)1.82697746
101Absent frontal sinuses (HP:0002688)1.81838975
102Inguinal hernia (HP:0000023)1.80952963
103Inappropriate behavior (HP:0000719)1.80777750
104Abnormality of skull ossification (HP:0002703)1.80456540
105Broad long bones (HP:0005622)1.80405544
106Vascular tortuosity (HP:0004948)1.79071177
107Tracheomalacia (HP:0002779)1.77155616
108Coxa vara (HP:0002812)1.77025329
109Atonic seizures (HP:0010819)1.75655486
110Thin bony cortex (HP:0002753)1.74446786
111Disinhibition (HP:0000734)1.73923738
112Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.73525512
113Flat cornea (HP:0007720)1.73125667
114Elbow flexion contracture (HP:0002987)1.72990535
115Syringomyelia (HP:0003396)1.72735875
116Spinal cord lesions (HP:0100561)1.72735875
117Exotropia (HP:0000577)1.71753734
118Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71328848
119Exostoses (HP:0100777)1.70373298
120Delayed gross motor development (HP:0002194)1.70248378
121Increased variability in muscle fiber diameter (HP:0003557)1.69902934
122Sparse lateral eyebrow (HP:0005338)1.69433673
123Venous insufficiency (HP:0005293)1.68961417
124Increased number of teeth (HP:0011069)1.68896404
125Back pain (HP:0003418)1.68399831
126Progressive cerebellar ataxia (HP:0002073)1.67694483
127Decreased skull ossification (HP:0004331)1.67407362
128Striae distensae (HP:0001065)1.66532168
129Hypoplasia of the iris (HP:0007676)1.66046969
130Protruding ear (HP:0000411)1.65991661
131Congenital glaucoma (HP:0001087)1.65498161
132Obstructive sleep apnea (HP:0002870)1.64962089
133Limited hip movement (HP:0008800)1.64296590
134Bell-shaped thorax (HP:0001591)1.63758166
135Osteopenia (HP:0000938)1.63682607
136Acanthosis nigricans (HP:0000956)1.63572226
137Abnormality of the 2nd finger (HP:0004100)1.63540823
138Cutaneous finger syndactyly (HP:0010554)1.63494421
139Broad-based gait (HP:0002136)1.63483580
140Focal motor seizures (HP:0011153)1.63439179
141Arterial tortuosity (HP:0005116)1.61839614
142Agitation (HP:0000713)1.60925818
143Polyphagia (HP:0002591)1.60871922
144Turricephaly (HP:0000262)1.59226399
145Amblyopia (HP:0000646)1.58713940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.94269001
2MYLK4.52982037
3DDR23.72922241
4LATS23.19368325
5MAPK132.83156555
6NEK92.71697444
7TGFBR22.70577559
8DYRK22.70522633
9PTK22.69876115
10MINK12.56015449
11EPHB22.55190766
12CASK2.53913630
13ERBB32.51950882
14NTRK32.47541119
15AKT32.33083007
16TESK12.30964036
17NTRK22.22311241
18MAP3K42.20311418
19MET2.02055805
20PDGFRA2.01745473
21SIK21.94027227
22RIPK11.93090235
23FLT31.88675697
24MAP2K71.84639633
25PNCK1.84593871
26PAK41.84477301
27MAP3K91.84155402
28PRKD21.79767670
29LIMK11.66390790
30PLK21.60955907
31STK381.53993734
32SIK11.51640515
33PAK61.51267562
34MOS1.50992600
35KSR11.42257851
36TRPM71.34196665
37PHKG11.32911984
38PHKG21.32911984
39BMPR1B1.32196163
40ERN11.31305041
41FER1.24317318
42UHMK11.20825452
43PIK3CG1.12587060
44CAMK1G1.09637966
45MAP2K41.07369820
46EPHA41.02233734
47LATS11.02108564
48CDK141.01863316
49DAPK21.00613708
50STK30.98190768
51ADRBK10.97654374
52RPS6KA20.97146104
53LMTK20.95347512
54CDK50.94964350
55CDK180.92511503
56CDK150.91906905
57GSK3A0.91595153
58PAK30.90707114
59STK38L0.90428131
60ROCK10.89871244
61DYRK1A0.86940440
62PRKCG0.86872304
63CSNK1G20.86821012
64GRK50.84580198
65EPHA30.82712672
66ABL20.80967841
67DMPK0.80873940
68MAP3K120.80389060
69MST1R0.79028807
70CDK11A0.77816173
71NTRK10.77044900
72PIM20.76752265
73PKN20.76174748
74MTOR0.74664263
75MKNK10.73633868
76CLK10.72598153
77TNIK0.69759877
78MKNK20.68837707
79CAMK2A0.67200006
80BMX0.65890802
81PRKCE0.63457748
82KIT0.63044727
83PDGFRB0.62659135
84EPHB10.62064378
85MELK0.61632634
86CSNK1G30.61438446
87FGR0.60927163
88RET0.58792309
89TTN0.58701496
90MARK20.58384867
91MAPK70.57760698
92GRK70.57366435
93EIF2AK20.57253237
94MAP2K10.56706633
95CSNK1G10.56524217
96PRKG20.55821186
97CSNK1A1L0.54248705
98JAK10.53973163
99MAP3K60.53733329
100TGFBR10.53454774
101CAMKK10.53110561
102EEF2K0.52459815
103PRKCZ0.52101875
104DAPK30.52071543
105FGFR10.51844313
106ROCK20.51239617
107GRK10.51000649
108MAPKAPK30.50888760
109BCR0.50834829
110ICK0.50211741
111TYRO30.49101123
112PAK20.48993697
113PTK2B0.48717928
114NME10.47609288
115MAPK90.47571629
116PRKD30.47446186
117TRIB30.47108232
118CDK80.46460611
119MAPK40.46039107
120PAK10.45962119
121FGFR20.45536904
122PRKD10.44103019
123STK110.44016532
124CDK60.42926413
125FES0.42455846
126ERBB40.42303799
127CAMK40.40921989
128PKN10.40095456
129MAP3K30.39979928
130ILK0.39866759
131MAPK80.39327763
132MAPK120.38914502
133YES10.37976811
134PIK3CA0.37353750
135BRAF0.36864981
136CDC42BPA0.36573765
137ARAF0.35705336
138WNK10.35340905
139CAMK2B0.35257748
140SCYL20.35023121
141EPHA20.34682015
142INSR0.34472537
143CAMK2G0.33480707
144CAMK10.32477033
145WNK30.32406617
146ALK0.31460314
147ABL10.29808301
148KSR20.28565102
149PRKAA20.27396616
150ADRBK20.26546572
151SRC0.25341435
152IRAK30.25224522
153PRKCH0.24783616
154TAOK20.23959928
155JAK30.23670336
156BRSK20.22922137
157RAF10.21242417

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.46447377
2Axon guidance_Homo sapiens_hsa043602.12068991
3Synaptic vesicle cycle_Homo sapiens_hsa047211.89278012
4Small cell lung cancer_Homo sapiens_hsa052221.72564592
5ECM-receptor interaction_Homo sapiens_hsa045121.71351047
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63567020
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.61566479
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.60255759
9Dopaminergic synapse_Homo sapiens_hsa047281.60237629
10Hedgehog signaling pathway_Homo sapiens_hsa043401.59879319
11Basal cell carcinoma_Homo sapiens_hsa052171.57121916
12PPAR signaling pathway_Homo sapiens_hsa033201.55193687
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53424511
14Long-term depression_Homo sapiens_hsa047301.50560926
15Gap junction_Homo sapiens_hsa045401.49509176
16Long-term potentiation_Homo sapiens_hsa047201.49141517
17Cholinergic synapse_Homo sapiens_hsa047251.46358692
18Cocaine addiction_Homo sapiens_hsa050301.45615608
19Circadian entrainment_Homo sapiens_hsa047131.45142771
20Amphetamine addiction_Homo sapiens_hsa050311.44124754
21Melanoma_Homo sapiens_hsa052181.42881086
22GABAergic synapse_Homo sapiens_hsa047271.41978515
23Glioma_Homo sapiens_hsa052141.40108813
24Glutamatergic synapse_Homo sapiens_hsa047241.39222001
25Melanogenesis_Homo sapiens_hsa049161.36588033
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35902069
27Wnt signaling pathway_Homo sapiens_hsa043101.30553844
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.29255861
29Focal adhesion_Homo sapiens_hsa045101.29085744
30Serotonergic synapse_Homo sapiens_hsa047261.27595062
31Morphine addiction_Homo sapiens_hsa050321.26387704
32GnRH signaling pathway_Homo sapiens_hsa049121.24521208
33ErbB signaling pathway_Homo sapiens_hsa040121.22995484
34Hippo signaling pathway_Homo sapiens_hsa043901.22733653
35Renin secretion_Homo sapiens_hsa049241.22332997
36Olfactory transduction_Homo sapiens_hsa047401.21177266
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21098714
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.21037758
39Colorectal cancer_Homo sapiens_hsa052101.19566312
40Phagosome_Homo sapiens_hsa041451.19440278
41Proteoglycans in cancer_Homo sapiens_hsa052051.19265588
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17346186
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17341081
44TGF-beta signaling pathway_Homo sapiens_hsa043501.16228726
45Estrogen signaling pathway_Homo sapiens_hsa049151.15335309
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12908906
47Amoebiasis_Homo sapiens_hsa051461.12543460
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09976207
49Oxytocin signaling pathway_Homo sapiens_hsa049211.09344608
50Dilated cardiomyopathy_Homo sapiens_hsa054141.07499514
51Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06719924
52Fatty acid biosynthesis_Homo sapiens_hsa000611.05252590
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.04721751
54Protein digestion and absorption_Homo sapiens_hsa049741.04024951
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.03685037
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03321429
57Renal cell carcinoma_Homo sapiens_hsa052111.02066883
58Sulfur metabolism_Homo sapiens_hsa009201.01202214
59Vibrio cholerae infection_Homo sapiens_hsa051101.00918817
60Endometrial cancer_Homo sapiens_hsa052131.00225949
61Fatty acid elongation_Homo sapiens_hsa000620.98513988
62Viral myocarditis_Homo sapiens_hsa054160.97034272
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96005142
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93841345
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93115707
66Taste transduction_Homo sapiens_hsa047420.92334079
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88804958
68Rap1 signaling pathway_Homo sapiens_hsa040150.88309574
69Salivary secretion_Homo sapiens_hsa049700.88106345
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.87747597
71Rheumatoid arthritis_Homo sapiens_hsa053230.87543212
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87492969
73Ras signaling pathway_Homo sapiens_hsa040140.87168002
74N-Glycan biosynthesis_Homo sapiens_hsa005100.86397537
75MicroRNAs in cancer_Homo sapiens_hsa052060.85615209
76Glycerolipid metabolism_Homo sapiens_hsa005610.85216999
77Collecting duct acid secretion_Homo sapiens_hsa049660.84253672
78Malaria_Homo sapiens_hsa051440.84219108
79AMPK signaling pathway_Homo sapiens_hsa041520.84187200
80Gastric acid secretion_Homo sapiens_hsa049710.84085570
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83515297
82MAPK signaling pathway_Homo sapiens_hsa040100.82880089
83Cardiac muscle contraction_Homo sapiens_hsa042600.82738875
84Adherens junction_Homo sapiens_hsa045200.82724964
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82724625
86Renin-angiotensin system_Homo sapiens_hsa046140.82659948
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82390579
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80941645
89Calcium signaling pathway_Homo sapiens_hsa040200.80598623
90Oocyte meiosis_Homo sapiens_hsa041140.79346021
91p53 signaling pathway_Homo sapiens_hsa041150.78376131
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78029271
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.75679599
94cAMP signaling pathway_Homo sapiens_hsa040240.75136213
95Salmonella infection_Homo sapiens_hsa051320.74514776
96Pyruvate metabolism_Homo sapiens_hsa006200.71888364
97Alzheimers disease_Homo sapiens_hsa050100.71491314
98Insulin secretion_Homo sapiens_hsa049110.71420661
99Type II diabetes mellitus_Homo sapiens_hsa049300.70647752
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70480705
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70474306
102Prostate cancer_Homo sapiens_hsa052150.69936832
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69808563
104Chronic myeloid leukemia_Homo sapiens_hsa052200.69543215
105Pathways in cancer_Homo sapiens_hsa052000.69517926
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69422007
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68595694
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.66853871
109Oxidative phosphorylation_Homo sapiens_hsa001900.64752671
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.64550082
111Thyroid cancer_Homo sapiens_hsa052160.63260320
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63033294
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62868351
114Tight junction_Homo sapiens_hsa045300.62179418
115Pancreatic cancer_Homo sapiens_hsa052120.62016790
116VEGF signaling pathway_Homo sapiens_hsa043700.61463312
117Parkinsons disease_Homo sapiens_hsa050120.60265024
118Bladder cancer_Homo sapiens_hsa052190.59806633
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59383716
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59229865
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56890050
122Fatty acid metabolism_Homo sapiens_hsa012120.54867368
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.53633484
124Prion diseases_Homo sapiens_hsa050200.51621657
125Shigellosis_Homo sapiens_hsa051310.49872577
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49074068
127Thyroid hormone synthesis_Homo sapiens_hsa049180.47496946
128Complement and coagulation cascades_Homo sapiens_hsa046100.45681011
129Insulin signaling pathway_Homo sapiens_hsa049100.43561340
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.42251669
131Endocytosis_Homo sapiens_hsa041440.42051354
132Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40887142
133Glucagon signaling pathway_Homo sapiens_hsa049220.39790006
134Galactose metabolism_Homo sapiens_hsa000520.39208958
135Vitamin B6 metabolism_Homo sapiens_hsa007500.37603126
136Glutathione metabolism_Homo sapiens_hsa004800.35976268
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35688590
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34977865
139Platelet activation_Homo sapiens_hsa046110.34705057
140Fatty acid degradation_Homo sapiens_hsa000710.33793123
141Sphingolipid metabolism_Homo sapiens_hsa006000.32585935
142Mineral absorption_Homo sapiens_hsa049780.32158153
143Dorso-ventral axis formation_Homo sapiens_hsa043200.31461776
144Lysine degradation_Homo sapiens_hsa003100.29986094
145Ovarian steroidogenesis_Homo sapiens_hsa049130.29841017

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