CLEC4GP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil chemotaxis (GO:0048245)9.55811399
2eosinophil migration (GO:0072677)8.55398711
3synaptic vesicle endocytosis (GO:0048488)6.14131686
4synaptic vesicle maturation (GO:0016188)5.93169273
5synaptic vesicle exocytosis (GO:0016079)5.55832998
6protein localization to synapse (GO:0035418)5.09941181
7membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.08325692
8regulation of macrophage chemotaxis (GO:0010758)4.99301000
9cellular response to ethanol (GO:0071361)4.96522016
10cellular potassium ion homeostasis (GO:0030007)4.87187538
11regulation of synaptic vesicle exocytosis (GO:2000300)4.86635811
12detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.69933696
13detection of temperature stimulus involved in sensory perception (GO:0050961)4.69933696
14positive regulation of guanylate cyclase activity (GO:0031284)4.65280240
15gamma-aminobutyric acid transport (GO:0015812)4.56144893
16sodium ion export (GO:0071436)4.50122501
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.47654199
18glutamate secretion (GO:0014047)4.43134313
19positive regulation of cAMP-mediated signaling (GO:0043950)4.40058837
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.27240315
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.22833144
22regulation of guanylate cyclase activity (GO:0031282)4.18397329
23regulation of synaptic vesicle transport (GO:1902803)4.17956714
24regulation of short-term neuronal synaptic plasticity (GO:0048172)4.16827157
25neurotransmitter secretion (GO:0007269)4.05988899
26retinal cone cell development (GO:0046549)3.97198718
27membrane depolarization during action potential (GO:0086010)3.96792349
28neuronal action potential propagation (GO:0019227)3.86447244
29regulation of mononuclear cell migration (GO:0071675)3.82952848
30receptor guanylyl cyclase signaling pathway (GO:0007168)3.82519934
31layer formation in cerebral cortex (GO:0021819)3.75573861
32regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.70380380
33establishment of synaptic vesicle localization (GO:0097480)3.65920451
34synaptic vesicle transport (GO:0048489)3.65920451
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.64723605
36negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.63641654
37negative regulation of metanephros development (GO:0072217)3.55852149
38detection of temperature stimulus (GO:0016048)3.55014060
39positive regulation of synapse maturation (GO:0090129)3.52401655
40adhesion of symbiont to host cell (GO:0044650)3.47848916
41virion attachment to host cell (GO:0019062)3.47848916
42cerebellar granule cell differentiation (GO:0021707)3.44788346
43positive regulation of male gonad development (GO:2000020)3.44355931
44synaptic transmission, glutamatergic (GO:0035249)3.43239018
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38793041
46diaphragm development (GO:0060539)3.36975483
47mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.35885469
48glutamate receptor signaling pathway (GO:0007215)3.35502953
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.30875963
50skeletal muscle organ development (GO:0060538)3.29801514
51response to auditory stimulus (GO:0010996)3.28671351
52neurotransmitter transport (GO:0006836)3.17447444
53C4-dicarboxylate transport (GO:0015740)3.16002607
54positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15841083
55negative regulation of telomere maintenance (GO:0032205)3.12867280
56regulation of synapse structural plasticity (GO:0051823)3.10897136
57protein-cofactor linkage (GO:0018065)3.10480556
58adhesion of symbiont to host (GO:0044406)3.07420254
59regulation of voltage-gated calcium channel activity (GO:1901385)3.06105596
60clathrin coat assembly (GO:0048268)3.04164796
61potassium ion homeostasis (GO:0055075)3.03368767
62regulation of neuronal synaptic plasticity (GO:0048168)3.02337414
63regulation of synapse maturation (GO:0090128)2.99767895
64postsynaptic membrane organization (GO:0001941)2.99747080
65positive regulation of dendritic spine development (GO:0060999)2.98987472
66vocalization behavior (GO:0071625)2.98614025
67membrane depolarization (GO:0051899)2.98509068
68locomotory exploration behavior (GO:0035641)2.97938977
69positive regulation of cGMP biosynthetic process (GO:0030828)2.95521184
70regulation of vesicle fusion (GO:0031338)2.94785976
71regulation of cAMP-mediated signaling (GO:0043949)2.92211510
72regulation of excitatory postsynaptic membrane potential (GO:0060079)2.88693449
73regulation of dendritic spine morphogenesis (GO:0061001)2.87352998
74proline transport (GO:0015824)2.87167009
75adult walking behavior (GO:0007628)2.86158609
76sleep (GO:0030431)2.84998435
77dendritic spine morphogenesis (GO:0060997)2.84795156
78dendritic spine organization (GO:0097061)2.83604459
79auditory receptor cell stereocilium organization (GO:0060088)2.83023554
80regulation of neurotransmitter levels (GO:0001505)2.81890929
81regulation of female gonad development (GO:2000194)2.81833675
82axon ensheathment in central nervous system (GO:0032291)2.81628687
83central nervous system myelination (GO:0022010)2.81628687
84potassium ion import (GO:0010107)2.81616696
85neuromuscular process controlling posture (GO:0050884)2.80267467
86establishment of vesicle localization (GO:0051650)2.79444127
87G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.79098432
88cellular sodium ion homeostasis (GO:0006883)2.78683637
89epithelial cell differentiation involved in kidney development (GO:0035850)2.78312780
90neuron-neuron synaptic transmission (GO:0007270)2.78032769
91detection of light stimulus involved in sensory perception (GO:0050962)2.77136246
92detection of light stimulus involved in visual perception (GO:0050908)2.77136246
93exploration behavior (GO:0035640)2.75988721
94positive regulation of dendritic spine morphogenesis (GO:0061003)2.75860080
95regulation of cGMP biosynthetic process (GO:0030826)2.74845611
96L-amino acid import (GO:0043092)2.73729920
97regulation of cardiac muscle cell contraction (GO:0086004)2.73583689
98long term synaptic depression (GO:0060292)2.73068960
99negative regulation of dendrite morphogenesis (GO:0050774)2.72038982
100phosphorelay signal transduction system (GO:0000160)2.71836581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.21300518
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15939395
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.96363888
4REST_21632747_ChIP-Seq_MESCs_Mouse2.87644461
5EZH2_22144423_ChIP-Seq_EOC_Human2.81590046
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.66933297
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66749249
8SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55678135
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53664759
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50219997
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50219997
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46618982
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38801689
14GBX2_23144817_ChIP-Seq_PC3_Human2.32793699
15EGR1_19032775_ChIP-ChIP_M12_Human2.29423407
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.23230484
17DROSHA_22980978_ChIP-Seq_HELA_Human2.20740232
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.18982484
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.13859854
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.10814870
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09909807
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.08126746
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.02106080
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94575318
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.94294709
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92666366
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.91562679
28NR3C1_23031785_ChIP-Seq_PC12_Mouse1.86343576
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79744939
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.79318587
31RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.58883007
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44546721
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43070146
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40888268
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37637251
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32382624
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31232544
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29520725
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.29514218
40RNF2_27304074_Chip-Seq_NSC_Mouse1.29026104
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27577792
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26188397
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16578996
44TET1_21490601_ChIP-Seq_MESCs_Mouse1.16307163
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14581909
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13133752
47TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11931329
48OCT4_19829295_ChIP-Seq_ESCs_Human1.11444954
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09599747
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09078993
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06440711
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06062720
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05365602
54SMC4_20622854_ChIP-Seq_HELA_Human1.03126928
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02502533
56CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02261849
57CMYC_18555785_Chip-Seq_ESCs_Mouse1.00695997
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.00559215
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00189185
60CBX2_27304074_Chip-Seq_ESCs_Mouse0.99723716
61RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98283349
62FLI1_27457419_Chip-Seq_LIVER_Mouse0.97949460
63AR_19668381_ChIP-Seq_PC3_Human0.97390515
64GATA1_26923725_Chip-Seq_HPCs_Mouse0.95718655
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95549471
66LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92243739
67NANOG_18555785_Chip-Seq_ESCs_Mouse0.91724290
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91477207
69STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.91047140
70BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90889773
71HTT_18923047_ChIP-ChIP_STHdh_Human0.90499776
72BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90279458
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88965073
74P68_20966046_ChIP-Seq_HELA_Human0.87590903
75* CTCF_27219007_Chip-Seq_Bcells_Human0.87413643
76JUN_21703547_ChIP-Seq_K562_Human0.87194959
77STAT3_18555785_Chip-Seq_ESCs_Mouse0.85927185
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.85274612
79KDM2B_26808549_Chip-Seq_K562_Human0.85034153
80ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84187855
81SOX2_21211035_ChIP-Seq_LN229_Gbm0.84017097
82YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83968672
83AR_25329375_ChIP-Seq_VCAP_Human0.83416467
84ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83267355
85GATA3_21867929_ChIP-Seq_TH1_Mouse0.82980938
86PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82590043
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81779549
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.80768244
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80746338
90SMAD4_21799915_ChIP-Seq_A2780_Human0.80186538
91SMAD4_21741376_ChIP-Seq_ESCs_Human0.80026232
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79707829
93EP300_21415370_ChIP-Seq_HL-1_Mouse0.79637903
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78803936
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78533838
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78273540
97SMAD4_21741376_ChIP-Seq_EPCs_Human0.78202849
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.78089379
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77493277
100PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76598667

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.53992958
2MP0000751_myopathy4.30115649
3MP0004270_analgesia4.03652078
4MP0003880_abnormal_central_pattern3.99568114
5MP0001501_abnormal_sleep_pattern3.52356849
6MP0009046_muscle_twitch3.49124266
7MP0002064_seizures3.36329218
8MP0001486_abnormal_startle_reflex3.35789565
9MP0003635_abnormal_synaptic_transmissio3.28155073
10MP0002272_abnormal_nervous_system3.16274961
11MP0009745_abnormal_behavioral_response3.08126866
12MP0001188_hyperpigmentation2.85470696
13MP0002063_abnormal_learning/memory/cond2.45370700
14MP0001968_abnormal_touch/_nociception2.30442094
15MP0003329_amyloid_beta_deposits2.27297850
16MP0005551_abnormal_eye_electrophysiolog2.24584404
17MP0000920_abnormal_myelination2.23937299
18MP0002572_abnormal_emotion/affect_behav2.23769004
19MP0005423_abnormal_somatic_nervous2.15191892
20MP0001485_abnormal_pinna_reflex2.12583593
21MP0002734_abnormal_mechanical_nocicepti1.93427488
22MP0001440_abnormal_grooming_behavior1.85956080
23MP0005167_abnormal_blood-brain_barrier1.83498026
24MP0002733_abnormal_thermal_nociception1.81596555
25MP0002736_abnormal_nociception_after1.75416528
26MP0000604_amyloidosis1.73728099
27MP0002735_abnormal_chemical_nociception1.71354650
28MP0001970_abnormal_pain_threshold1.67851259
29MP0004742_abnormal_vestibular_system1.66261847
30MP0004885_abnormal_endolymph1.61181134
31MP0008877_abnormal_DNA_methylation1.61177930
32MP0008569_lethality_at_weaning1.58140858
33MP0008995_early_reproductive_senescence1.52089355
34MP0003690_abnormal_glial_cell1.45550599
35MP0005386_behavior/neurological_phenoty1.45327741
36MP0004924_abnormal_behavior1.45327741
37MP0003633_abnormal_nervous_system1.44566266
38MP0003879_abnormal_hair_cell1.44402283
39MP0002067_abnormal_sensory_capabilities1.41446882
40MP0005377_hearing/vestibular/ear_phenot1.41198058
41MP0003878_abnormal_ear_physiology1.41198058
42MP0003631_nervous_system_phenotype1.39372471
43MP0000747_muscle_weakness1.39346727
44MP0002653_abnormal_ependyma_morphology1.33398154
45MP0004233_abnormal_muscle_weight1.31291197
46MP0000749_muscle_degeneration1.27775610
47MP0006276_abnormal_autonomic_nervous1.27515972
48MP0002822_catalepsy1.26803174
49MP0003183_abnormal_peptide_metabolism1.26451196
50MP0002229_neurodegeneration1.25159823
51MP0004811_abnormal_neuron_physiology1.23471440
52MP0003632_abnormal_nervous_system1.23441806
53MP0002066_abnormal_motor_capabilities/c1.21124236
54MP0002557_abnormal_social/conspecific_i1.21091324
55MP0003123_paternal_imprinting1.20117174
56MP0003787_abnormal_imprinting1.20043391
57MP0003122_maternal_imprinting1.18525336
58MP0001502_abnormal_circadian_rhythm1.12738308
59MP0004215_abnormal_myocardial_fiber1.11571539
60MP0003191_abnormal_cellular_cholesterol1.07880868
61MP0003315_abnormal_perineum_morphology1.03957024
62MP0002882_abnormal_neuron_morphology1.03810803
63MP0005535_abnormal_body_temperature1.03473680
64MP0006138_congestive_heart_failure0.99292060
65MP0008260_abnormal_autophagy0.97076436
66MP0000639_abnormal_adrenal_gland0.92290375
67MP0009384_cardiac_valve_regurgitation0.88860030
68MP0000537_abnormal_urethra_morphology0.88197965
69MP0001963_abnormal_hearing_physiology0.86889733
70MP0008874_decreased_physiological_sensi0.86484174
71MP0010386_abnormal_urinary_bladder0.85609339
72MP0003075_altered_response_to0.85082249
73MP0009840_abnormal_foam_cell0.84584189
74MP0002090_abnormal_vision0.84079403
75MP0000955_abnormal_spinal_cord0.79750206
76MP0005595_abnormal_vascular_smooth0.79690906
77MP0003172_abnormal_lysosome_physiology0.79393478
78MP0004142_abnormal_muscle_tone0.78874998
79MP0005646_abnormal_pituitary_gland0.76738746
80MP0000566_synostosis0.76365749
81MP0002184_abnormal_innervation0.76292135
82MP0000343_altered_response_to0.75313649
83MP0009780_abnormal_chondrocyte_physiolo0.73721322
84MP0001919_abnormal_reproductive_system0.71760288
85MP0001177_atelectasis0.71111796
86MP0002295_abnormal_pulmonary_circulatio0.66838440
87MP0003828_pulmonary_edema0.65949494
88MP0000778_abnormal_nervous_system0.65106493
89MP0005310_abnormal_salivary_gland0.61799353
90MP0000750_abnormal_muscle_regeneration0.60919250
91MP0001324_abnormal_eye_pigmentation0.60455550
92MP0002277_abnormal_respiratory_mucosa0.60319813
93MP0004484_altered_response_of0.56919977
94MP0003121_genomic_imprinting0.56481536
95MP0005448_abnormal_energy_balance0.55960676
96MP0003638_abnormal_response/metabolism_0.55127744
97MP0009785_altered_susceptibility_to0.54688753
98MP0002148_abnormal_hypersensitivity_rea0.54227410
99MP0005410_abnormal_fertilization0.53703938
100MP0004019_abnormal_vitamin_homeostasis0.53666444

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.66992801
2Myokymia (HP:0002411)5.26784017
3Epileptic encephalopathy (HP:0200134)5.21428682
4Amblyopia (HP:0000646)4.33368798
5Gaze-evoked nystagmus (HP:0000640)4.14245950
6Ulnar claw (HP:0001178)4.07850302
7Focal seizures (HP:0007359)4.00754198
8Systemic lupus erythematosus (HP:0002725)4.00690863
9Mesangial abnormality (HP:0001966)3.90184585
10Abnormality of the vocal cords (HP:0008777)3.78919890
11Shoulder girdle muscle weakness (HP:0003547)3.71044399
12Supranuclear gaze palsy (HP:0000605)3.67457252
13Peripheral hypomyelination (HP:0007182)3.67236869
14Atonic seizures (HP:0010819)3.52835399
15Gonadal dysgenesis (HP:0000133)3.50327981
16Anomalous pulmonary venous return (HP:0010772)3.45037502
17Abnormal ventriculo-arterial connection (HP:0011563)3.26655974
18Transposition of the great arteries (HP:0001669)3.26655974
19Abnormal connection of the cardiac segments (HP:0011545)3.26655974
20Febrile seizures (HP:0002373)3.24259087
21Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.23523268
22Hypoplastic left heart (HP:0004383)3.20366932
23Degeneration of the lateral corticospinal tracts (HP:0002314)3.15293210
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.15293210
25Mutism (HP:0002300)3.14116724
26Glomerulonephritis (HP:0000099)3.14032628
27Action tremor (HP:0002345)3.12214559
28Testicular neoplasm (HP:0010788)3.10707999
29Abnormal eating behavior (HP:0100738)3.09180341
30Hydroureter (HP:0000072)3.05421922
31Sleep apnea (HP:0010535)2.96109366
32Abnormality of the pulmonary veins (HP:0011718)2.93500431
33Spastic gait (HP:0002064)2.91561959
34Abnormality of binocular vision (HP:0011514)2.88982649
35Diplopia (HP:0000651)2.88982649
36Neurofibrillary tangles (HP:0002185)2.88237688
37Ankle clonus (HP:0011448)2.87229009
38Generalized tonic-clonic seizures (HP:0002069)2.83569270
39Cerebral hypomyelination (HP:0006808)2.81498780
40Abnormality of the lower motor neuron (HP:0002366)2.79813762
41Complement deficiency (HP:0004431)2.69165616
42Dysmetria (HP:0001310)2.68945067
43Abnormality of the corticospinal tract (HP:0002492)2.68049355
44Postural instability (HP:0002172)2.66555965
45Hyperventilation (HP:0002883)2.63981193
46Progressive inability to walk (HP:0002505)2.56220719
47Coronal craniosynostosis (HP:0004440)2.55700125
48Hemiplegia (HP:0002301)2.55254736
49Hypoplastic heart (HP:0001961)2.49366484
50Urinary bladder sphincter dysfunction (HP:0002839)2.44342008
51Papilledema (HP:0001085)2.42208994
52Optic nerve hypoplasia (HP:0000609)2.41459871
53Hypokalemic alkalosis (HP:0001949)2.40623612
54Amyotrophic lateral sclerosis (HP:0007354)2.38251172
55Abnormality of the labia minora (HP:0012880)2.37668895
56Type II lissencephaly (HP:0007260)2.34281288
57Absence seizures (HP:0002121)2.32017064
58Exercise-induced myalgia (HP:0003738)2.31141456
59Limb dystonia (HP:0002451)2.29555205
60Neuronal loss in central nervous system (HP:0002529)2.26687094
61Dialeptic seizures (HP:0011146)2.26228674
62Abnormality of the middle phalanges of the toes (HP:0010183)2.25665978
63Emotional lability (HP:0000712)2.24275667
64Pelvic girdle muscle weakness (HP:0003749)2.19181155
65Rapidly progressive (HP:0003678)2.11237347
66Neoplasm of head and neck (HP:0012288)2.06482237
67Esophageal neoplasm (HP:0100751)2.06482237
68Flared iliac wings (HP:0002869)2.06190851
69Germ cell neoplasia (HP:0100728)2.04583484
70Lower limb muscle weakness (HP:0007340)2.04260266
71Retinal dysplasia (HP:0007973)1.99402807
72Tetraplegia (HP:0002445)1.98415935
73Polyphagia (HP:0002591)1.96845944
74Memory impairment (HP:0002354)1.96817960
75CNS hypomyelination (HP:0003429)1.96486873
76Progressive cerebellar ataxia (HP:0002073)1.96445568
77Status epilepticus (HP:0002133)1.95128549
78Centrally nucleated skeletal muscle fibers (HP:0003687)1.93850783
79Cerebral inclusion bodies (HP:0100314)1.92994431
80True hermaphroditism (HP:0010459)1.91434272
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91035341
82Sensory axonal neuropathy (HP:0003390)1.91029266
83Choreoathetosis (HP:0001266)1.89602642
84Periauricular skin pits (HP:0100277)1.89581582
85Preauricular pit (HP:0004467)1.89581582
86Urinary urgency (HP:0000012)1.88897212
87Increased serum pyruvate (HP:0003542)1.88808906
88Xerostomia (HP:0000217)1.86816962
89Abnormality of the musculature of the pelvis (HP:0001469)1.85104854
90Abnormality of the hip-girdle musculature (HP:0001445)1.85104854
91Iris hypopigmentation (HP:0007730)1.85069645
92Torticollis (HP:0000473)1.84215360
93Hyperaldosteronism (HP:0000859)1.83868568
94Glomerulosclerosis (HP:0000096)1.83826829
95Truncal ataxia (HP:0002078)1.83691581
96Annular pancreas (HP:0001734)1.83615458
97Depression (HP:0000716)1.82032014
98Rimmed vacuoles (HP:0003805)1.81876851
99Abnormality of glycolipid metabolism (HP:0010969)1.79622866
100Abnormality of glycosphingolipid metabolism (HP:0004343)1.79622866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.45958828
2CDK193.70835516
3MAP3K123.38994701
4DAPK23.32229057
5OXSR13.21931079
6CAMKK22.83053057
7EPHA42.70722277
8NTRK32.61835271
9SIK22.35597406
10MAP3K42.25309239
11STK382.25244676
12DYRK1A2.17020533
13MAP3K112.11873840
14MARK12.11274204
15PNCK2.10186525
16CAMKK12.03475867
17MINK12.02174043
18PAK62.00338904
19LATS21.91987188
20NTRK21.89594219
21CAMK11.61120622
22CDK181.46746074
23CDK151.42155371
24CDK51.38406601
25UHMK11.38109612
26RIPK11.36307865
27MAP2K41.34190269
28CDK11A1.25520374
29TRIM281.21587806
30ERN11.20427250
31GRK51.16412993
32JAK11.15839901
33BMPR21.13149165
34PRKCG1.12704466
35KSR11.11635198
36CDK141.11578392
37FES1.10867352
38CAMK1G1.10515058
39RIPK41.08185570
40CAMK2B1.02989646
41PRKCH1.02571283
42SGK2231.02545318
43SGK4941.02545318
44PRKD30.96468931
45SGK20.95738870
46PRKCZ0.93081464
47MAPK130.91711980
48CAMK2A0.90659180
49EPHB20.90346553
50ALK0.90157783
51PHKG20.89759775
52PHKG10.89759775
53TIE10.88451057
54BRSK10.88440791
55MAP3K10.83274792
56SIK30.83134574
57CAMK40.83133712
58ABL20.82132168
59FER0.81044969
60CAMK2G0.80438550
61FGFR20.77402584
62MAPKAPK50.75723000
63NTRK10.71811430
64DAPK10.69258343
65MAP2K60.67841575
66SGK10.67408655
67PINK10.66269131
68STK390.64943944
69WNK10.63538950
70SGK30.62642828
71PDK20.62005212
72NEK60.60532659
73STK110.59986692
74CASK0.58471291
75PDPK10.57810441
76DAPK30.56451102
77MAPK120.56078102
78PRKG20.53950994
79MAPK100.52145064
80MAP3K70.49580815
81PKN10.48279530
82TYK20.47258319
83PLK20.43728602
84PDK10.43373536
85PRKCE0.42427738
86CAMK2D0.42072694
87RPS6KA30.41174443
88EPHA30.39406628
89INSRR0.38886783
90SYK0.38705264
91MAP3K50.38032558
92PRKACA0.37228462
93RPS6KB10.37118597
94WNK40.35730814
95PRKCA0.35623311
96TLK10.35447903
97MAP3K90.34755032
98PAK30.32769083
99FYN0.30520766
100JAK20.30114898

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.26758069
2Nicotine addiction_Homo sapiens_hsa050333.79956479
3Synaptic vesicle cycle_Homo sapiens_hsa047213.69564404
4Staphylococcus aureus infection_Homo sapiens_hsa051502.89830997
5GABAergic synapse_Homo sapiens_hsa047272.45103829
6Morphine addiction_Homo sapiens_hsa050322.35615631
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34320424
8Circadian entrainment_Homo sapiens_hsa047132.23720834
9Glutamatergic synapse_Homo sapiens_hsa047242.23694957
10Asthma_Homo sapiens_hsa053102.12594643
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.90326306
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84047627
13Cardiac muscle contraction_Homo sapiens_hsa042601.79430383
14Amphetamine addiction_Homo sapiens_hsa050311.70631285
15Long-term potentiation_Homo sapiens_hsa047201.66823264
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65097442
17Insulin secretion_Homo sapiens_hsa049111.64865143
18Allograft rejection_Homo sapiens_hsa053301.63771818
19Oxidative phosphorylation_Homo sapiens_hsa001901.61218015
20Collecting duct acid secretion_Homo sapiens_hsa049661.59476072
21Gastric acid secretion_Homo sapiens_hsa049711.55766564
22Autoimmune thyroid disease_Homo sapiens_hsa053201.53410403
23Rheumatoid arthritis_Homo sapiens_hsa053231.46009433
24Phagosome_Homo sapiens_hsa041451.45825756
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45465949
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43893151
27Salivary secretion_Homo sapiens_hsa049701.37440291
28Type I diabetes mellitus_Homo sapiens_hsa049401.36421460
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34742950
30Dopaminergic synapse_Homo sapiens_hsa047281.34004259
31Cocaine addiction_Homo sapiens_hsa050301.31861536
32Alzheimers disease_Homo sapiens_hsa050101.31076208
33Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.29793287
34Arginine and proline metabolism_Homo sapiens_hsa003301.28575022
35Graft-versus-host disease_Homo sapiens_hsa053321.28291275
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22614354
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15283505
38Calcium signaling pathway_Homo sapiens_hsa040201.15024350
39Prion diseases_Homo sapiens_hsa050201.11283287
40Chemokine signaling pathway_Homo sapiens_hsa040621.09279779
41Circadian rhythm_Homo sapiens_hsa047101.08394480
42Taste transduction_Homo sapiens_hsa047421.04178308
43Parkinsons disease_Homo sapiens_hsa050121.03333513
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01882473
45Renin secretion_Homo sapiens_hsa049241.00820639
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99897072
47Cholinergic synapse_Homo sapiens_hsa047250.99750055
48Tuberculosis_Homo sapiens_hsa051520.97611791
49Histidine metabolism_Homo sapiens_hsa003400.95690527
50Leishmaniasis_Homo sapiens_hsa051400.92752302
51Oxytocin signaling pathway_Homo sapiens_hsa049210.91351794
52Olfactory transduction_Homo sapiens_hsa047400.91121636
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90862938
54cAMP signaling pathway_Homo sapiens_hsa040240.90193626
55Serotonergic synapse_Homo sapiens_hsa047260.87852900
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86301947
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85646015
58GnRH signaling pathway_Homo sapiens_hsa049120.85635370
59Long-term depression_Homo sapiens_hsa047300.81926116
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79227536
61Viral myocarditis_Homo sapiens_hsa054160.75947660
62Complement and coagulation cascades_Homo sapiens_hsa046100.75377044
63Mineral absorption_Homo sapiens_hsa049780.70698042
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67074008
65Vibrio cholerae infection_Homo sapiens_hsa051100.66243373
66Bile secretion_Homo sapiens_hsa049760.65735217
67Pancreatic secretion_Homo sapiens_hsa049720.65664391
68Fatty acid elongation_Homo sapiens_hsa000620.55397556
69Hedgehog signaling pathway_Homo sapiens_hsa043400.54933002
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52887109
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52388215
72Huntingtons disease_Homo sapiens_hsa050160.51934254
73Endocytosis_Homo sapiens_hsa041440.48902678
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47555530
75Ras signaling pathway_Homo sapiens_hsa040140.46808392
76Lysosome_Homo sapiens_hsa041420.46642045
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46155185
78Nitrogen metabolism_Homo sapiens_hsa009100.45679174
79Melanogenesis_Homo sapiens_hsa049160.44462541
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43922307
81Phenylalanine metabolism_Homo sapiens_hsa003600.43739837
82Folate biosynthesis_Homo sapiens_hsa007900.41676249
83beta-Alanine metabolism_Homo sapiens_hsa004100.40779571
84Vitamin B6 metabolism_Homo sapiens_hsa007500.40587211
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40475303
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40375479
87Ovarian steroidogenesis_Homo sapiens_hsa049130.39877794
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36563009
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32066093
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.31795292
91Arginine biosynthesis_Homo sapiens_hsa002200.30872901
92Gap junction_Homo sapiens_hsa045400.30003602
93MAPK signaling pathway_Homo sapiens_hsa040100.28844146
94Pyruvate metabolism_Homo sapiens_hsa006200.27614050
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.25395687
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24898131
97Estrogen signaling pathway_Homo sapiens_hsa049150.24874483
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.24753170
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.23020784
100Antigen processing and presentation_Homo sapiens_hsa046120.22732381

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