CLEC4G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)8.53512303
2exogenous drug catabolic process (GO:0042738)8.37726319
3epoxygenase P450 pathway (GO:0019373)8.32935905
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.62590647
5L-phenylalanine catabolic process (GO:0006559)7.62590647
6L-phenylalanine metabolic process (GO:0006558)7.30415610
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.30415610
8aromatic amino acid family catabolic process (GO:0009074)6.84156189
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.45618331
10tryptophan catabolic process (GO:0006569)6.17485575
11indole-containing compound catabolic process (GO:0042436)6.17485575
12indolalkylamine catabolic process (GO:0046218)6.17485575
13kynurenine metabolic process (GO:0070189)6.04007438
14bile acid biosynthetic process (GO:0006699)5.97042593
15disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.84801614
16killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.84801614
17tryptophan metabolic process (GO:0006568)5.80546821
18glyoxylate metabolic process (GO:0046487)5.78422050
19alpha-linolenic acid metabolic process (GO:0036109)5.71320017
20urea metabolic process (GO:0019627)5.69081012
21urea cycle (GO:0000050)5.69081012
22high-density lipoprotein particle remodeling (GO:0034375)5.65314697
23negative regulation of fibrinolysis (GO:0051918)5.63915168
24regulation of fibrinolysis (GO:0051917)5.44486021
25peptidyl-glutamic acid carboxylation (GO:0017187)5.43721183
26protein carboxylation (GO:0018214)5.43721183
27drug metabolic process (GO:0017144)5.43170928
28complement activation, alternative pathway (GO:0006957)5.38650819
29cysteine metabolic process (GO:0006534)5.34902788
30sulfur amino acid catabolic process (GO:0000098)5.34099504
31regulation of protein activation cascade (GO:2000257)5.33995238
32ethanol metabolic process (GO:0006067)5.24480327
33nitrogen cycle metabolic process (GO:0071941)5.23692842
34serine family amino acid catabolic process (GO:0009071)5.12205058
35bile acid metabolic process (GO:0008206)5.11327630
36acute-phase response (GO:0006953)5.01076808
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.97761562
38regulation of complement activation (GO:0030449)4.96909517
39aromatic amino acid family metabolic process (GO:0009072)4.96605504
40regulation of cholesterol esterification (GO:0010872)4.94357505
41reverse cholesterol transport (GO:0043691)4.92413442
42oxidative demethylation (GO:0070989)4.90533414
43regulation of triglyceride catabolic process (GO:0010896)4.88966618
44plasma lipoprotein particle remodeling (GO:0034369)4.82044172
45protein-lipid complex remodeling (GO:0034368)4.82044172
46macromolecular complex remodeling (GO:0034367)4.82044172
47tyrosine metabolic process (GO:0006570)4.81389988
48phospholipid efflux (GO:0033700)4.67893737
49homocysteine metabolic process (GO:0050667)4.67124707
50negative regulation of sterol transport (GO:0032372)4.64825588
51negative regulation of cholesterol transport (GO:0032375)4.64825588
52alpha-amino acid catabolic process (GO:1901606)4.64660743
53regulation of humoral immune response (GO:0002920)4.64492806
54triglyceride homeostasis (GO:0070328)4.63813167
55acylglycerol homeostasis (GO:0055090)4.63813167
56amino-acid betaine metabolic process (GO:0006577)4.63639602
57lysine catabolic process (GO:0006554)4.56987758
58lysine metabolic process (GO:0006553)4.56987758
59cellular ketone body metabolic process (GO:0046950)4.56767806
60glycine metabolic process (GO:0006544)4.42418774
61plasma lipoprotein particle clearance (GO:0034381)4.41542118
62bile acid and bile salt transport (GO:0015721)4.41473587
63coenzyme catabolic process (GO:0009109)4.40870819
64imidazole-containing compound metabolic process (GO:0052803)4.39697971
65indolalkylamine metabolic process (GO:0006586)4.36512992
66regulation of plasminogen activation (GO:0010755)4.29064421
67S-adenosylmethionine metabolic process (GO:0046500)4.27630388
68cellular biogenic amine catabolic process (GO:0042402)4.26636370
69amine catabolic process (GO:0009310)4.26636370
70cellular amino acid catabolic process (GO:0009063)4.26111416
71glutamate metabolic process (GO:0006536)4.25490442
72cholesterol efflux (GO:0033344)4.24622454
73cellular glucuronidation (GO:0052695)4.21457732
74serine family amino acid metabolic process (GO:0009069)4.15091299
75benzene-containing compound metabolic process (GO:0042537)4.12112070
76ethanol oxidation (GO:0006069)4.10304634
77plasma lipoprotein particle assembly (GO:0034377)4.07350801
78phenylpropanoid metabolic process (GO:0009698)4.06979533
79low-density lipoprotein particle remodeling (GO:0034374)4.06924529
80arginine metabolic process (GO:0006525)4.03518312
81killing of cells of other organism (GO:0031640)4.02099458
82disruption of cells of other organism (GO:0044364)4.02099458
83cellular modified amino acid catabolic process (GO:0042219)4.01551504
84fibrinolysis (GO:0042730)4.01373756
85aldehyde catabolic process (GO:0046185)3.99496605
86dicarboxylic acid biosynthetic process (GO:0043650)3.99303646
87ketone body metabolic process (GO:1902224)3.95249847
88blood coagulation, intrinsic pathway (GO:0007597)3.94079377
89drug catabolic process (GO:0042737)3.93772104
90serine family amino acid biosynthetic process (GO:0009070)3.93510791
91negative regulation of protein activation cascade (GO:2000258)3.93135023
92positive regulation of lipoprotein lipase activity (GO:0051006)3.85875189
93positive regulation of triglyceride lipase activity (GO:0061365)3.85875189
94cofactor catabolic process (GO:0051187)3.82811487
95complement activation, classical pathway (GO:0006958)3.80548316
96negative regulation of lipase activity (GO:0060192)3.78176516
97acute inflammatory response (GO:0002526)3.78146573
98protein activation cascade (GO:0072376)3.77809475
99complement activation (GO:0006956)3.77627769
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.76818732
101very-low-density lipoprotein particle assembly (GO:0034379)3.76773641
102negative regulation of blood coagulation (GO:0030195)3.76241488
103negative regulation of hemostasis (GO:1900047)3.76241488
104cholesterol homeostasis (GO:0042632)3.74199837
105positive regulation of lipid catabolic process (GO:0050996)3.74085380
106carboxylic acid catabolic process (GO:0046395)3.73781950
107organic acid catabolic process (GO:0016054)3.73781950
108uronic acid metabolic process (GO:0006063)3.72219913
109glucuronate metabolic process (GO:0019585)3.72219913
110phospholipid homeostasis (GO:0055091)3.70471774
111plasma lipoprotein particle organization (GO:0071827)3.67644664
112sterol homeostasis (GO:0055092)3.67629667
113regulation of cholesterol homeostasis (GO:2000188)3.67379241
114positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.67213240
115protein-lipid complex assembly (GO:0065005)3.66834497
116regulation of bile acid biosynthetic process (GO:0070857)3.63781630
117acetyl-CoA metabolic process (GO:0006084)3.63047613
118short-chain fatty acid metabolic process (GO:0046459)3.62371254
119cytolysis (GO:0019835)3.60067395
120opsonization (GO:0008228)3.59652567
121NAD biosynthetic process (GO:0009435)3.56620849
122alkaloid metabolic process (GO:0009820)3.52267094
123heme transport (GO:0015886)3.45042146
124positive regulation of hemostasis (GO:1900048)3.41425939
125positive regulation of blood coagulation (GO:0030194)3.41425939
126positive regulation of fatty acid biosynthetic process (GO:0045723)3.39640774
127negative regulation of coagulation (GO:0050819)3.36728102
128regulation of acute inflammatory response (GO:0002673)3.28135435
129negative regulation of wound healing (GO:0061045)3.24963842
130regulation of apoptotic cell clearance (GO:2000425)3.23954897
131detection of bacterium (GO:0016045)3.22202681
132negative regulation of complement activation (GO:0045916)3.13511316
133positive regulation of coagulation (GO:0050820)3.10130121
134detection of other organism (GO:0098543)3.07561975
135oxaloacetate metabolic process (GO:0006107)3.06183752
136sodium-independent organic anion transport (GO:0043252)3.01610765

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.42216019
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19432072
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.07933005
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.50830725
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.29373594
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.12533200
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80019975
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.03360222
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.93450530
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.39007037
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04953664
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9591793
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92917591
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89835980
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86372129
16SCL_19346495_ChIP-Seq_HPC-7_Human1.79658260
17* IRF8_27001747_Chip-Seq_BMDM_Mouse1.78456898
18* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76807694
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.75135619
20VDR_21846776_ChIP-Seq_THP-1_Human1.72539379
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.57403140
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57127905
23HTT_18923047_ChIP-ChIP_STHdh_Human1.56053424
24VDR_24763502_ChIP-Seq_THP-1_Human1.55445003
25* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53888416
26CLOCK_20551151_ChIP-Seq_293T_Human1.46572926
27BCL6_27268052_Chip-Seq_Bcells_Human1.45761618
28ELF1_20517297_ChIP-Seq_JURKAT_Human1.42547008
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40218351
30HNF4A_19822575_ChIP-Seq_HepG2_Human1.37840051
31GATA1_22025678_ChIP-Seq_K562_Human1.32093470
32* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30787693
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30602578
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28905340
35RXRA_24833708_ChIP-Seq_LIVER_Mouse1.24500239
36SPI1_20517297_ChIP-Seq_HL60_Human1.23077750
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16160253
38DROSHA_22980978_ChIP-Seq_HELA_Human1.14432707
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14425252
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14417847
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14229577
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13911841
43* E2F1_20622854_ChIP-Seq_HELA_Human1.13291650
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12631155
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12018722
46P68_20966046_ChIP-Seq_HELA_Human1.11381695
47SPI1_23127762_ChIP-Seq_K562_Human1.11299538
48SA1_27219007_Chip-Seq_Bcells_Human1.10569382
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09385935
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.06264899
51SPI1_23547873_ChIP-Seq_NB4_Human1.06120094
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.05585590
53RAC3_21632823_ChIP-Seq_H3396_Human1.05470483
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05188259
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04187973
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03056421
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02052702
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00218101
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00042859
60DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99405212
61CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99236574
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98077480
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97589652
64PHF8_20622854_ChIP-Seq_HELA_Human0.97423057
65ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96538141
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95819336
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93239399
68P300_27268052_Chip-Seq_Bcells_Human0.93158839
69VDR_24787735_ChIP-Seq_THP-1_Human0.92930923
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92615761
71P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.91903899
72SOX2_21211035_ChIP-Seq_LN229_Human0.91902753
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.90980977
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90571457
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90130130
76* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89479861
77SMC4_20622854_ChIP-Seq_HELA_Human0.88284785
78SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88057765
79MAF_26560356_Chip-Seq_TH1_Human0.87209577
80AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87022115
81KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86165445
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85975203
83CTCF_20526341_ChIP-Seq_ESCs_Human0.85438962
84RUNX_20019798_ChIP-Seq_JUKART_Human0.85335080
85UTX_26944678_Chip-Seq_JUKART_Human0.85092399
86ERA_21632823_ChIP-Seq_H3396_Human0.84929881
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84514072
88KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83535496
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83422821
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82560769
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81844730
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81751163
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80092628
94RARA_24833708_ChIP-Seq_LIVER_Mouse0.78110696
95GATA4_25053715_ChIP-Seq_YYC3_Human0.78089430
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77445604
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75546424
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74901689
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74850884
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74379638
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73853030
102ZNF263_19887448_ChIP-Seq_K562_Human0.73498028
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69987415
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.66934810
105RARB_24833708_ChIP-Seq_LIVER_Mouse0.66806230
106* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63228865
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62417028
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62075339
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62053057
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61427862
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59559440
112CEBPB_22108803_ChIP-Seq_LS180_Human0.58329773
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.58060424
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.58060424
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58055664
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57810916
117ESR2_21235772_ChIP-Seq_MCF-7_Human0.56429489
118EGR1_19032775_ChIP-ChIP_M12_Human0.53649762
119AR_20517297_ChIP-Seq_VCAP_Human0.53540111
120STAT1_17558387_ChIP-Seq_HELA_Human0.53517312
121MYC_19915707_ChIP-ChIP_AK7_Human0.53281321
122* LXR_22292898_ChIP-Seq_THP-1_Human0.52744762
123ESET_19884257_ChIP-Seq_ESCs_Mouse0.52648286
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51383582
125FOXA1_25552417_ChIP-Seq_VCAP_Human0.51058209
126P53_21459846_ChIP-Seq_SAOS-2_Human0.50308416
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49281503
128CBP_21632823_ChIP-Seq_H3396_Human0.47649814
129GATA1_19941826_ChIP-Seq_K562_Human0.47052262
130FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46472187
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.45475233
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.45114129
133PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45065837
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.44378747
135TAF2_19829295_ChIP-Seq_ESCs_Human0.43522038
136TAF15_26573619_Chip-Seq_HEK293_Human0.43469265
137GATA2_19941826_ChIP-Seq_K562_Human0.42450731
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42239743
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.41945356
140MYC_27129775_Chip-Seq_CORNEA_Mouse0.41298587
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40181072
142STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39790997
143FOXO3_23340844_ChIP-Seq_DLD1_Human0.39756116
144CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.39545594
145BCAT_22108803_ChIP-Seq_LS180_Human0.39274474
146LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.39198885
147E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.38941470
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.38904035
149ERG_20517297_ChIP-Seq_VCAP_Human0.38503254
150CDX2_20551321_ChIP-Seq_CACO-2_Human0.38147148
151* SPI1_26923725_Chip-Seq_HPCs_Mouse0.37783757
152FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.37271284
153* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.36847908
154BCOR_27268052_Chip-Seq_Bcells_Human0.36581494
155EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.35771161
156SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34407501
157PPAR_26484153_Chip-Seq_NCI-H1993_Human0.33998355
158SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.33846027
159ESR1_21235772_ChIP-Seq_MCF-7_Human0.33496686
160NCOR_22424771_ChIP-Seq_293T_Human0.32912206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.33809187
2MP0005360_urolithiasis7.50880166
3MP0005085_abnormal_gallbladder_physiolo6.44745507
4MP0005365_abnormal_bile_salt6.14391654
5MP0008875_abnormal_xenobiotic_pharmacok5.17113001
6MP0003806_abnormal_nucleotide_metabolis4.27907091
7MP0003252_abnormal_bile_duct3.86823194
8MP0010329_abnormal_lipoprotein_level3.64791755
9MP0009840_abnormal_foam_cell3.33853868
10MP0005083_abnormal_biliary_tract3.07372919
11MP0003195_calcinosis2.84325402
12MP0005332_abnormal_amino_acid2.73153783
13MP0001666_abnormal_nutrient_absorption2.55769172
14MP0003191_abnormal_cellular_cholesterol2.38928629
15MP0000609_abnormal_liver_physiology2.16840887
16MP0004019_abnormal_vitamin_homeostasis2.11858952
17MP0002118_abnormal_lipid_homeostasis2.11421564
18MP0009785_altered_susceptibility_to1.98231874
19MP0002138_abnormal_hepatobiliary_system1.93534882
20MP0003868_abnormal_feces_composition1.88322376
21MP0003303_peritoneal_inflammation1.85728997
22MP0005319_abnormal_enzyme/_coenzyme1.82227538
23MP0003172_abnormal_lysosome_physiology1.80645413
24MP0002419_abnormal_innate_immunity1.73678501
25MP0009697_abnormal_copulation1.70335007
26MP0001764_abnormal_homeostasis1.68910966
27MP0005025_abnormal_response_to1.65236885
28MP0005584_abnormal_enzyme/coenzyme_acti1.57603535
29MP0005671_abnormal_response_to1.52874563
30MP0005451_abnormal_body_composition1.50308954
31MP0003011_delayed_dark_adaptation1.46817649
32MP0005058_abnormal_lysosome_morphology1.43988461
33MP0001835_abnormal_antigen_presentation1.37283749
34MP0001986_abnormal_taste_sensitivity1.33691038
35MP0003186_abnormal_redox_activity1.27804110
36MP0003656_abnormal_erythrocyte_physiolo1.27769348
37MP0001790_abnormal_immune_system1.27643216
38MP0005387_immune_system_phenotype1.27643216
39MP0001800_abnormal_humoral_immune1.23363955
40MP0001545_abnormal_hematopoietic_system1.23179123
41MP0005397_hematopoietic_system_phenotyp1.23179123
42MP0009643_abnormal_urine_homeostasis1.22850411
43MP0000598_abnormal_liver_morphology1.17813506
44MP0005000_abnormal_immune_tolerance1.16693388
45MP0005647_abnormal_sex_gland1.16244708
46MP0002148_abnormal_hypersensitivity_rea1.12782721
47MP0003705_abnormal_hypodermis_morpholog1.11151364
48MP0000604_amyloidosis1.09290980
49MP0000685_abnormal_immune_system1.08968135
50MP0010368_abnormal_lymphatic_system1.08001977
51MP0002254_reproductive_system_inflammat1.07126199
52MP0009764_decreased_sensitivity_to1.06422107
53MP0009763_increased_sensitivity_to1.04780777
54MP0002723_abnormal_immune_serum1.02012281
55MP0002452_abnormal_antigen_presenting0.96028108
56MP0005636_abnormal_mineral_homeostasis0.91979630
57MP0008469_abnormal_protein_level0.91138724
58MP0009642_abnormal_blood_homeostasis0.87948089
59MP0010155_abnormal_intestine_physiology0.87808197
60MP0002420_abnormal_adaptive_immunity0.86691709
61MP0001851_eye_inflammation0.86339146
62MP0001819_abnormal_immune_cell0.85622282
63MP0001533_abnormal_skeleton_physiology0.84920913
64MP0006036_abnormal_mitochondrial_physio0.84242837
65MP0003879_abnormal_hair_cell0.82697618
66MP0005408_hypopigmentation0.82005847
67MP0005670_abnormal_white_adipose0.79592720
68MP0009765_abnormal_xenobiotic_induced0.79101021
69MP0005084_abnormal_gallbladder_morpholo0.79043618
70MP0005376_homeostasis/metabolism_phenot0.78987332
71MP0002078_abnormal_glucose_homeostasis0.76929520
72MP0002876_abnormal_thyroid_physiology0.72594156
73MP0002971_abnormal_brown_adipose0.72579110
74MP0000689_abnormal_spleen_morphology0.71932869
75MP0005334_abnormal_fat_pad0.70384543
76MP0000343_altered_response_to0.69610502
77MP0004130_abnormal_muscle_cell0.67464700
78MP0005535_abnormal_body_temperature0.66646828
79MP0005220_abnormal_exocrine_pancreas0.65677733
80MP0004147_increased_porphyrin_level0.64767423
81MP0003690_abnormal_glial_cell0.64541852
82MP0000716_abnormal_immune_system0.64251066
83MP0005266_abnormal_metabolism0.63092762
84MP0001661_extended_life_span0.62534945
85MP0003329_amyloid_beta_deposits0.61610498
86MP0001756_abnormal_urination0.61550000
87MP0002332_abnormal_exercise_endurance0.61417717
88MP0004510_myositis0.60883132
89MP0009053_abnormal_anal_canal0.60760454
90MP0005464_abnormal_platelet_physiology0.60624850
91MP0000639_abnormal_adrenal_gland0.60406577
92MP0002405_respiratory_system_inflammati0.59982975
93MP0006035_abnormal_mitochondrial_morpho0.57799536
94MP0002282_abnormal_trachea_morphology0.55989018
95MP0005448_abnormal_energy_balance0.55219221
96MP0001501_abnormal_sleep_pattern0.54072583
97MP0003724_increased_susceptibility_to0.50479252
98MP0002822_catalepsy0.49168806
99MP0003436_decreased_susceptibility_to0.48475124
100MP0003638_abnormal_response/metabolism_0.47572814
101MP0005395_other_phenotype0.46099215
102MP0008874_decreased_physiological_sensi0.46048765
103MP0002136_abnormal_kidney_physiology0.45870501
104MP0002928_abnormal_bile_duct0.44781212
105MP0008873_increased_physiological_sensi0.43915756
106MP0003718_maternal_effect0.43297924
107MP0004782_abnormal_surfactant_physiolog0.42917018
108MP0003075_altered_response_to0.42067068
109MP0002837_dystrophic_cardiac_calcinosis0.40949254
110MP0003953_abnormal_hormone_level0.40795472
111MP0005248_abnormal_Harderian_gland0.38101286
112MP0005166_decreased_susceptibility_to0.37764148
113MP0006082_CNS_inflammation0.36094890
114MP0000249_abnormal_blood_vessel0.36062481
115MP0004381_abnormal_hair_follicle0.35402948
116MP0009115_abnormal_fat_cell0.35290900
117MP0008872_abnormal_physiological_respon0.35230438
118MP0009672_abnormal_birth_weight0.33306725
119MP0005666_abnormal_adipose_tissue0.32862993
120MP0001853_heart_inflammation0.31657421
121MP0000579_abnormal_nail_morphology0.31049846
122MP0004883_abnormal_blood_vessel0.30714942
123MP0000230_abnormal_systemic_arterial0.30488399
124MP0002970_abnormal_white_adipose0.30483520
125MP0001845_abnormal_inflammatory_respons0.30220139
126MP0002796_impaired_skin_barrier0.29903025
127MP0001243_abnormal_dermal_layer0.29888036
128MP0002168_other_aberrant_phenotype0.28317251
129MP0001881_abnormal_mammary_gland0.25787164
130MP0005167_abnormal_blood-brain_barrier0.25265325
131MP0009384_cardiac_valve_regurgitation0.24047568
132MP0005164_abnormal_response_to0.23828868
133MP0002132_abnormal_respiratory_system0.21834302
134MP0005595_abnormal_vascular_smooth0.21563504

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.49181317
2Deep venous thrombosis (HP:0002625)7.48112797
3Intrahepatic cholestasis (HP:0001406)7.25330275
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.66380301
5Prolonged partial thromboplastin time (HP:0003645)6.61851486
6Hypobetalipoproteinemia (HP:0003563)6.57299988
7Xanthomatosis (HP:0000991)6.26854728
8Hyperlipoproteinemia (HP:0010980)5.70034473
9Complement deficiency (HP:0004431)5.30378409
10Joint hemorrhage (HP:0005261)4.96009809
11Hypolipoproteinemia (HP:0010981)4.87422662
12Hyperammonemia (HP:0001987)4.55143842
13Abnormality of the common coagulation pathway (HP:0010990)4.50059380
14Epidermoid cyst (HP:0200040)4.46272935
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.45053492
16Hyperglycinemia (HP:0002154)4.36540749
17Abnormality of methionine metabolism (HP:0010901)4.29804727
18Ketosis (HP:0001946)4.25579069
19Hypoalphalipoproteinemia (HP:0003233)4.24587145
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.22503433
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.11432215
22Fat malabsorption (HP:0002630)4.09184978
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.04920996
24Abnormality of complement system (HP:0005339)3.87910788
25Abnormality of pyrimidine metabolism (HP:0004353)3.83303222
26Hyperglycinuria (HP:0003108)3.82719628
27Abnormality of glycine metabolism (HP:0010895)3.82705948
28Abnormality of serine family amino acid metabolism (HP:0010894)3.82705948
29Hypoglycemic coma (HP:0001325)3.80664887
30Abnormality of the intrinsic pathway (HP:0010989)3.80219126
31Hypercholesterolemia (HP:0003124)3.67442518
32Conjugated hyperbilirubinemia (HP:0002908)3.63730982
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37439784
34Hyperbilirubinemia (HP:0002904)3.35221108
35Abnormality of fatty-acid metabolism (HP:0004359)3.30267952
36Purpura (HP:0000979)3.23777828
37Spontaneous abortion (HP:0005268)3.16495342
38Steatorrhea (HP:0002570)3.10346747
39Delayed CNS myelination (HP:0002188)3.09533890
40Abnormality of nucleobase metabolism (HP:0010932)3.05177789
41Abnormality of serum amino acid levels (HP:0003112)3.03279183
42Myocardial infarction (HP:0001658)3.02506716
43Ketoacidosis (HP:0001993)2.99967820
44Spontaneous hematomas (HP:0007420)2.99884310
45Hepatocellular carcinoma (HP:0001402)2.98104636
46Hypochromic microcytic anemia (HP:0004840)2.96828919
47Recurrent abscess formation (HP:0002722)2.86922742
48Metabolic acidosis (HP:0001942)2.75627397
49Systemic lupus erythematosus (HP:0002725)2.73095221
50Epistaxis (HP:0000421)2.72538302
51Skin nodule (HP:0200036)2.71597340
52Abnormality of purine metabolism (HP:0004352)2.66115072
53Meningitis (HP:0001287)2.63319255
54Acanthocytosis (HP:0001927)2.63314637
55Vascular calcification (HP:0004934)2.62514704
56Vacuolated lymphocytes (HP:0001922)2.58420271
57Dicarboxylic aciduria (HP:0003215)2.56334789
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56334789
59Lethargy (HP:0001254)2.56275261
60Increased serum ferritin (HP:0003281)2.51529351
61Neonatal hypoglycemia (HP:0001998)2.48512525
62Abnormal gallbladder morphology (HP:0012437)2.47354926
63Glomerulonephritis (HP:0000099)2.47282639
64Hypoglycemic seizures (HP:0002173)2.45525832
65Gangrene (HP:0100758)2.45344935
66Spastic diplegia (HP:0001264)2.42650589
67Cholelithiasis (HP:0001081)2.42117571
68Mitral stenosis (HP:0001718)2.41319114
69Gout (HP:0001997)2.38893874
70Hypochromic anemia (HP:0001931)2.38040128
71Abnormal gallbladder physiology (HP:0012438)2.36160542
72Cholecystitis (HP:0001082)2.36160542
73Cerebral edema (HP:0002181)2.35960606
74Recurrent gram-negative bacterial infections (HP:0005420)2.34992918
75Malnutrition (HP:0004395)2.34729326
76Amyloidosis (HP:0011034)2.34141826
77Chronic obstructive pulmonary disease (HP:0006510)2.33689751
78Obstructive lung disease (HP:0006536)2.33689751
79Gingival bleeding (HP:0000225)2.33668723
80Cardiovascular calcification (HP:0011915)2.32492023
81Irritability (HP:0000737)2.32443670
82Neonatal onset (HP:0003623)2.31628152
83Cerebral palsy (HP:0100021)2.27648849
84Menorrhagia (HP:0000132)2.26689064
85Esophageal varix (HP:0002040)2.22731617
86Thrombophlebitis (HP:0004418)2.18071967
87Joint swelling (HP:0001386)2.14754469
88Myositis (HP:0100614)2.13464660
89Pancreatitis (HP:0001733)2.13176029
90Sensorimotor neuropathy (HP:0007141)2.12598547
91Brushfield spots (HP:0001088)2.12449240
92Microcytic anemia (HP:0001935)2.11417881
93Late onset (HP:0003584)2.11288528
94Enlarged kidneys (HP:0000105)2.07953682
95Hemorrhage of the eye (HP:0011885)2.07267942
96Hemoptysis (HP:0002105)2.06001535
97Poikilocytosis (HP:0004447)2.05737179
98Vomiting (HP:0002013)2.05350628
99Orchitis (HP:0100796)2.03829164
100Retrobulbar optic neuritis (HP:0100654)2.03401918
101Optic neuritis (HP:0100653)2.03401918
102Opisthotonus (HP:0002179)2.01221910
103Abnormality of the gallbladder (HP:0005264)2.00737945
104Abnormality of macrophages (HP:0004311)1.99663215
105Generalized aminoaciduria (HP:0002909)1.99313150
106Eczematoid dermatitis (HP:0000976)1.98664927
107Hyperinsulinemic hypoglycemia (HP:0000825)1.98656703
108Abnormality of iron homeostasis (HP:0011031)1.97439248
109Abnormality of transition element cation homeostasis (HP:0011030)1.92161850
110Dysostosis multiplex (HP:0000943)1.92155672
111Rickets (HP:0002748)1.89463091
112Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87342824
113Abnormality of polysaccharide metabolism (HP:0011012)1.87342824
114Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87342824
115Renal cortical cysts (HP:0000803)1.86554796
116Recurrent bacterial skin infections (HP:0005406)1.85174172
117Elevated hepatic transaminases (HP:0002910)1.84878117
118Vasculitis (HP:0002633)1.84128359
119Anorexia (HP:0002039)1.83392286
120Hypophosphatemic rickets (HP:0004912)1.83090991
121Increased cerebral lipofuscin (HP:0011813)1.81943603
122Abnormal cartilage morphology (HP:0002763)1.81223670
123Pulmonary embolism (HP:0002204)1.80011484
124Impaired platelet aggregation (HP:0003540)1.79844449
125Abnormal platelet function (HP:0011869)1.79844449
126Status epilepticus (HP:0002133)1.79779505
127Hydroxyprolinuria (HP:0003080)1.78741063
128Abnormality of proline metabolism (HP:0010907)1.78741063
129Fair hair (HP:0002286)1.78649403
130Nephritis (HP:0000123)1.77136537
131Abnormal enzyme/coenzyme activity (HP:0012379)1.76350571
132Alkalosis (HP:0001948)1.75947844
133Abnormality of liposaccharide metabolism (HP:0010968)1.75894438
134Abnormality of glycosphingolipid metabolism (HP:0004343)1.75894438
135Abnormality of glycolipid metabolism (HP:0010969)1.75894438
136Increased neuronal autofluorescent lipopigment (HP:0002074)1.75859711
137Mucopolysacchariduria (HP:0008155)1.75769248
138Urinary glycosaminoglycan excretion (HP:0003541)1.75769248
139Arterial thrombosis (HP:0004420)1.74582488
140Gingivitis (HP:0000230)1.72585305
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.72114325
142Reticulocytosis (HP:0001923)1.71262761
143Osteomalacia (HP:0002749)1.69643093
144Pulmonary infiltrates (HP:0002113)1.69353613
145Atrioventricular block (HP:0001678)1.68264208
146Abnormality of the prostate (HP:0008775)1.65569315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.09629217
2FGFR44.67036407
3SIK14.57518459
4ERN14.28106071
5RIPK43.30262751
6TAOK33.13227869
7INSRR3.00680602
8TNK22.87813855
9ERBB42.77406260
10FES2.76272118
11PKN22.26552953
12MAP2K42.23845266
13MST1R2.00426963
14FLT31.91238269
15MAPK111.79783013
16CDK191.77586819
17PIK3CG1.77368950
18TYK21.75912896
19NTRK31.73179652
20TRIB31.72220146
21SYK1.66171140
22PRPF4B1.63387432
23DAPK21.60024342
24IRAK41.59443411
25KDR1.51052454
26PTK61.48839147
27CAMKK21.42221356
28BTK1.41370531
29ABL21.35859862
30MARK31.32316696
31LATS11.31132650
32PINK11.28571716
33JAK21.25396506
34NEK91.22967796
35FGFR21.21569589
36JAK31.20704530
37LYN1.15857489
38GRK61.15096824
39FRK1.14296130
40IKBKB1.13915045
41MAP2K31.13816000
42MAP3K71.11670832
43CAMKK11.11198439
44TBK11.10154612
45MAP3K111.09216113
46PRKAA21.07612094
47MATK1.06539354
48JAK11.03149751
49TIE11.03115244
50MAP3K141.02180472
51MAPK41.00910280
52TEC0.94917067
53TESK20.94177712
54EPHB10.94144611
55ERBB20.93607397
56TAOK10.92847949
57TXK0.92384848
58MAPK120.92085689
59MAPK150.92085286
60STK160.90242453
61TGFBR20.88585612
62STK110.87640637
63MAP4K20.86361876
64PTK2B0.85855864
65MAP3K30.85559013
66PRKCZ0.85460721
67EPHA30.85177777
68MAP3K100.85173471
69CDK60.85006456
70GRK70.83814980
71HCK0.82696892
72LCK0.82319876
73RIPK10.80835198
74RPS6KA20.78088385
75ARAF0.75684011
76SIK20.75055173
77MET0.74423517
78FGR0.74028273
79MAPK70.73389559
80ADRBK20.73370575
81PRKACG0.73126613
82CSK0.71873272
83STK38L0.71537216
84CAMK1D0.71494903
85DYRK1B0.71341309
86MAP2K60.68715296
87RPS6KL10.66903395
88RPS6KC10.66903395
89RPS6KA60.66713923
90ITK0.66358265
91CAMK2G0.65226812
92CSF1R0.64565939
93DAPK10.63437792
94PRKAA10.63346503
95MAP3K130.62651322
96GSK3A0.61352643
97SGK30.60514745
98PDK30.59540277
99PDK40.59540277
100MAP4K10.59262567
101IKBKE0.58039947
102PTK20.57108506
103CSNK1G10.56771149
104FGFR30.55704861
105PDPK10.54029973
106ICK0.53985109
107PIM10.53393485
108CDK40.51003231
109OXSR10.47940691
110GRK10.47428867
111PRKCQ0.47383854
112HIPK20.45586097
113IRAK30.44363630
114IGF1R0.43411111
115FYN0.42686793
116MARK20.42206943
117ABL10.41016784
118PRKACA0.39883581
119PRKCG0.39664474
120PRKD20.39503080
121SGK20.39256437
122EPHA40.39227275
123KSR10.38656552
124PDK10.38558585
125MAP3K10.36995539
126TAOK20.36995153
127CSNK1G30.36926883
128RET0.36678953
129MAP2K10.36677214
130PRKG10.36322393
131CAMK1G0.36064649
132CSNK1G20.35328167
133MAP3K60.34911673
134MAPK30.34645460
135BLK0.34248297
136KIT0.33998566
137MAP3K50.33835049
138EGFR0.33418928
139CHUK0.33289165
140PKN10.30829270
141CAMK40.30531163
142MTOR0.29913375
143MAP2K20.26054512
144IRAK10.24812596
145PRKCA0.24020064
146CSNK1A1L0.23034051
147SGK2230.22475343
148SGK4940.22475343
149ZAP700.22039812

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.54821658
2Nitrogen metabolism_Homo sapiens_hsa009103.52517904
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.38694178
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.33345973
5Arginine biosynthesis_Homo sapiens_hsa002203.04327711
6Complement and coagulation cascades_Homo sapiens_hsa046102.80199477
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.73209867
8Tryptophan metabolism_Homo sapiens_hsa003802.67866169
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62068104
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52741004
11Fatty acid degradation_Homo sapiens_hsa000712.50239776
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36647442
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25130366
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14926110
15Butanoate metabolism_Homo sapiens_hsa006502.13595601
16Peroxisome_Homo sapiens_hsa041462.09431923
17Chemical carcinogenesis_Homo sapiens_hsa052041.97750347
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95131558
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.92885227
20Histidine metabolism_Homo sapiens_hsa003401.92811464
21Propanoate metabolism_Homo sapiens_hsa006401.92423045
22PPAR signaling pathway_Homo sapiens_hsa033201.88079525
23Staphylococcus aureus infection_Homo sapiens_hsa051501.81415826
24Fatty acid metabolism_Homo sapiens_hsa012121.80295116
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.77629269
26Retinol metabolism_Homo sapiens_hsa008301.73798398
27Caffeine metabolism_Homo sapiens_hsa002321.73235394
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71445176
29beta-Alanine metabolism_Homo sapiens_hsa004101.70228739
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65112864
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63811818
32Selenocompound metabolism_Homo sapiens_hsa004501.58708449
33Phenylalanine metabolism_Homo sapiens_hsa003601.53645258
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51977825
35Bile secretion_Homo sapiens_hsa049761.48834941
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45976495
37Tyrosine metabolism_Homo sapiens_hsa003501.42664853
38Pyruvate metabolism_Homo sapiens_hsa006201.38568593
39Sulfur metabolism_Homo sapiens_hsa009201.34376470
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.32408711
41Fatty acid elongation_Homo sapiens_hsa000621.31829825
42Starch and sucrose metabolism_Homo sapiens_hsa005001.29719067
43Folate biosynthesis_Homo sapiens_hsa007901.28925882
44ABC transporters_Homo sapiens_hsa020101.21955791
45Biosynthesis of amino acids_Homo sapiens_hsa012301.18024633
46Fat digestion and absorption_Homo sapiens_hsa049751.16598203
47Steroid biosynthesis_Homo sapiens_hsa001001.16530292
48Carbon metabolism_Homo sapiens_hsa012001.11091372
49Asthma_Homo sapiens_hsa053101.07799918
50Sulfur relay system_Homo sapiens_hsa041221.02358878
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.00972916
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00354608
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98168660
54Arginine and proline metabolism_Homo sapiens_hsa003300.95619721
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.95549516
56Vitamin B6 metabolism_Homo sapiens_hsa007500.95030891
57Other glycan degradation_Homo sapiens_hsa005110.93572522
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87569667
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84001450
60Vitamin digestion and absorption_Homo sapiens_hsa049770.81725911
61Lysine degradation_Homo sapiens_hsa003100.79855034
62One carbon pool by folate_Homo sapiens_hsa006700.73555276
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73259483
64Glycerolipid metabolism_Homo sapiens_hsa005610.67847756
65Glutathione metabolism_Homo sapiens_hsa004800.64640349
66Leishmaniasis_Homo sapiens_hsa051400.61372766
67Allograft rejection_Homo sapiens_hsa053300.61350327
68Pentose phosphate pathway_Homo sapiens_hsa000300.57763064
69Fatty acid biosynthesis_Homo sapiens_hsa000610.55586012
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.53546055
71Autoimmune thyroid disease_Homo sapiens_hsa053200.51330783
72Hematopoietic cell lineage_Homo sapiens_hsa046400.51019613
73Graft-versus-host disease_Homo sapiens_hsa053320.49815904
74Metabolic pathways_Homo sapiens_hsa011000.45546861
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44545263
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43231132
77Type I diabetes mellitus_Homo sapiens_hsa049400.38682943
78Tuberculosis_Homo sapiens_hsa051520.38489832
79Prion diseases_Homo sapiens_hsa050200.35362350
80Lysosome_Homo sapiens_hsa041420.34635220
81Phagosome_Homo sapiens_hsa041450.32069111
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32054622
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32037295
84Osteoclast differentiation_Homo sapiens_hsa043800.29938808
85Linoleic acid metabolism_Homo sapiens_hsa005910.28631618
86Galactose metabolism_Homo sapiens_hsa000520.27508438
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.24492467
88Amoebiasis_Homo sapiens_hsa051460.24121474
89Insulin resistance_Homo sapiens_hsa049310.24064731
90Fructose and mannose metabolism_Homo sapiens_hsa000510.22738522
91B cell receptor signaling pathway_Homo sapiens_hsa046620.21552998
92Mineral absorption_Homo sapiens_hsa049780.20969208
93Rheumatoid arthritis_Homo sapiens_hsa053230.20387701
94Malaria_Homo sapiens_hsa051440.18768408
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.17849915
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15333886
97Glucagon signaling pathway_Homo sapiens_hsa049220.12697316
98Serotonergic synapse_Homo sapiens_hsa047260.10434749
99Primary immunodeficiency_Homo sapiens_hsa053400.09213553
100Type II diabetes mellitus_Homo sapiens_hsa049300.08925953
101Antigen processing and presentation_Homo sapiens_hsa046120.06881146
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.06237260
103AMPK signaling pathway_Homo sapiens_hsa041520.03562358
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.03258445
105Pertussis_Homo sapiens_hsa05133-0.2326678
106Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2230194
107Renin-angiotensin system_Homo sapiens_hsa04614-0.2155541
108Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2154647
109Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2104118
110Ether lipid metabolism_Homo sapiens_hsa00565-0.2084878
111Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2056137
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2018801
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1941373
114Hepatitis C_Homo sapiens_hsa05160-0.1853416
115Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1619503
116Regulation of autophagy_Homo sapiens_hsa04140-0.1501192
117Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1496803
118Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1458203
119Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1451238
120African trypanosomiasis_Homo sapiens_hsa05143-0.1245204
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1176623
122Insulin signaling pathway_Homo sapiens_hsa04910-0.1070683
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0971417
124Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0486569
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0329821
126Collecting duct acid secretion_Homo sapiens_hsa04966-0.0107603
127Chemokine signaling pathway_Homo sapiens_hsa04062-0.0033449

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