CLEC4D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.43249140
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.43249140
3positive regulation by organism of defense response of other organism involved in symbiotic interact7.43249140
4modulation by symbiont of host immune response (GO:0052553)7.43249140
5positive regulation by symbiont of host defense response (GO:0052509)7.43249140
6modulation by symbiont of host defense response (GO:0052031)7.43249140
7neutrophil activation involved in immune response (GO:0002283)5.88401287
8response to peptidoglycan (GO:0032494)5.80480764
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.65313225
10detection of other organism (GO:0098543)5.28869403
11macrophage activation involved in immune response (GO:0002281)5.20248419
12leukocyte migration involved in inflammatory response (GO:0002523)5.12739229
13detection of external biotic stimulus (GO:0098581)5.00222929
14respiratory burst (GO:0045730)4.99014746
15regulation of interferon-beta biosynthetic process (GO:0045357)4.95482934
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.88132652
17response to host immune response (GO:0052572)4.88132652
18positive regulation of chemokine biosynthetic process (GO:0045080)4.85543886
19positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.80139425
20detection of bacterium (GO:0016045)4.68404991
21positive regulation of interferon-alpha production (GO:0032727)4.61316648
22hydrogen peroxide biosynthetic process (GO:0050665)4.61095354
23detection of biotic stimulus (GO:0009595)4.49756184
24immunoglobulin mediated immune response (GO:0016064)4.46215105
25regulation of interferon-alpha production (GO:0032647)4.44879443
26response to host (GO:0075136)4.38581316
27response to host defenses (GO:0052200)4.38581316
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.38581316
29microglial cell activation (GO:0001774)4.25218689
30lipopolysaccharide-mediated signaling pathway (GO:0031663)4.20683789
31granulocyte activation (GO:0036230)4.12897045
32reactive oxygen species biosynthetic process (GO:1903409)4.10471465
33superoxide anion generation (GO:0042554)4.02614950
34positive regulation of heat generation (GO:0031652)4.01077637
35neutrophil activation (GO:0042119)3.94906788
36regulation of gamma-delta T cell activation (GO:0046643)3.93339852
37macrophage activation (GO:0042116)3.83965754
38positive regulation of mast cell activation (GO:0033005)3.82584173
39regulation of chemokine biosynthetic process (GO:0045073)3.81332243
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.81260854
41regulation of mast cell degranulation (GO:0043304)3.81188715
42regulation of mononuclear cell migration (GO:0071675)3.80616801
43myeloid cell activation involved in immune response (GO:0002275)3.79352209
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.75471689
45positive regulation of cellular amide metabolic process (GO:0034250)3.75183190
46positive regulation of mast cell degranulation (GO:0043306)3.72855318
47positive regulation of mast cell activation involved in immune response (GO:0033008)3.72855318
48regulation of fever generation (GO:0031620)3.72459187
49response to muramyl dipeptide (GO:0032495)3.71035287
50regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.66662457
51antigen processing and presentation of endogenous antigen (GO:0019883)3.66059720
52leukocyte aggregation (GO:0070486)3.63699249
53myeloid leukocyte mediated immunity (GO:0002444)3.63290280
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.63040360
55positive regulation of antigen processing and presentation (GO:0002579)3.60820977
56detection of molecule of bacterial origin (GO:0032490)3.60796141
57neutrophil mediated immunity (GO:0002446)3.60348325
58negative regulation of interleukin-12 production (GO:0032695)3.59844178
59regulation of mast cell activation involved in immune response (GO:0033006)3.56356488
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51125626
61low-density lipoprotein particle clearance (GO:0034383)3.51027745
62regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.49470833
63production of molecular mediator involved in inflammatory response (GO:0002532)3.49312961
64negative regulation of mast cell activation (GO:0033004)3.49010710
65regulation of mast cell activation (GO:0033003)3.46271328
66negative regulation of T cell mediated immunity (GO:0002710)3.45635322
67positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.45570484
68positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.42067472
69regulation of interleukin-8 biosynthetic process (GO:0045414)3.40767960
70regulation of dendritic cell antigen processing and presentation (GO:0002604)3.39645337
71natural killer cell mediated cytotoxicity (GO:0042267)3.38114751
72natural killer cell mediated immunity (GO:0002228)3.38114751
73regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.34805435
74negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.33874614
75positive regulation of interferon-beta production (GO:0032728)3.33470488
76germinal center formation (GO:0002467)3.30757672
77cellular extravasation (GO:0045123)3.30002326
78regulation of T-helper 2 cell differentiation (GO:0045628)3.29110082
79negative regulation of leukocyte mediated immunity (GO:0002704)3.28949819
80response to type I interferon (GO:0034340)3.28517291
81positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.26860541
82B cell mediated immunity (GO:0019724)3.23856261
83positive regulation of leukocyte degranulation (GO:0043302)3.23094719
84regulation of B cell receptor signaling pathway (GO:0050855)3.22073396
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.20984724
86neutrophil chemotaxis (GO:0030593)3.17677007
87positive regulation of gamma-delta T cell activation (GO:0046645)3.14773161
88regulation of leukocyte degranulation (GO:0043300)3.14680490
89regulation of cholesterol storage (GO:0010885)3.13763450
90negative regulation of interleukin-17 production (GO:0032700)3.13642732
91regulation of gamma-delta T cell differentiation (GO:0045586)3.13567766
92regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.11910984
93leukocyte degranulation (GO:0043299)3.11291350
94leukocyte mediated cytotoxicity (GO:0001909)3.11107545
95defense response to protozoan (GO:0042832)3.11054143
96regulation of antigen processing and presentation (GO:0002577)3.10079835
97neutrophil migration (GO:1990266)3.08744102
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.07533288
99negative regulation of T-helper cell differentiation (GO:0045623)3.07533288
100phagosome maturation (GO:0090382)3.07199291
101positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.06326338
102I-kappaB phosphorylation (GO:0007252)3.04901163
103positive regulation of chemokine production (GO:0032722)3.03880077
104regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02336300
105lymphocyte chemotaxis (GO:0048247)3.00521532
106regulation of tolerance induction (GO:0002643)3.00445943
107response to interleukin-15 (GO:0070672)2.99938679
108regulation of heat generation (GO:0031650)2.99810608
109negative regulation of cytokine production involved in immune response (GO:0002719)2.99283186
110response to protozoan (GO:0001562)2.97090725
111positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.96926870
112regulation of toll-like receptor signaling pathway (GO:0034121)2.96137927
113antigen processing and presentation via MHC class Ib (GO:0002475)2.95433966
114negative regulation of interleukin-6 production (GO:0032715)2.94394024
115T-helper 1 type immune response (GO:0042088)2.92104298
116regulation of macrophage cytokine production (GO:0010935)2.89984901
117defense response to fungus (GO:0050832)2.89232594
118cytokine secretion (GO:0050663)2.88585048
119regulation of podosome assembly (GO:0071801)2.88514699
120interferon-gamma-mediated signaling pathway (GO:0060333)2.87438206
121positive regulation of NF-kappaB import into nucleus (GO:0042346)2.87415636
122response to fungus (GO:0009620)2.86789134
123myeloid leukocyte activation (GO:0002274)2.86539296
124positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.86414191
125positive regulation of toll-like receptor signaling pathway (GO:0034123)2.83428281
126positive regulation of interleukin-6 production (GO:0032755)2.83089171
127positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.81850874
128type I interferon signaling pathway (GO:0060337)2.81828625
129cellular response to type I interferon (GO:0071357)2.81828625
130cellular response to zinc ion (GO:0071294)2.81509587
131positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.81226884
132negative regulation of myeloid cell apoptotic process (GO:0033033)2.80440545
133negative regulation of cell killing (GO:0031342)2.79160639
134negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.79160639
135granulocyte chemotaxis (GO:0071621)2.79083586

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.33118220
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.89563309
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.11085318
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.78611052
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.65035167
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.52063409
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse4.17151833
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.49660750
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49567619
10* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.40451796
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.23063136
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.17338568
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.12947053
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84392659
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67941714
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64220424
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63040435
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50669471
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.46848155
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.34519403
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.33409421
22SPI1_23547873_ChIP-Seq_NB4_Human2.31588362
23* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.07332057
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00146517
25PU_27001747_Chip-Seq_BMDM_Mouse1.91883718
26SPI1_23127762_ChIP-Seq_K562_Human1.87206148
27VDR_24763502_ChIP-Seq_THP-1_Human1.84454237
28VDR_24787735_ChIP-Seq_THP-1_Human1.83766494
29SCL_19346495_ChIP-Seq_HPC-7_Human1.83753850
30* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.82706871
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78063655
32* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.76990377
33* RUNX1_22412390_ChIP-Seq_EML_Mouse1.74277056
34* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73128082
35* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.68661757
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61494039
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61429507
38MYB_26560356_Chip-Seq_TH2_Human1.54743638
39RUNX_20019798_ChIP-Seq_JUKART_Human1.50746780
40* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.48429875
41* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44025700
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40456556
43* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39663736
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39614434
45MAF_26560356_Chip-Seq_TH1_Human1.38113694
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34608265
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32948583
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32188159
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.31903667
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31845573
51VDR_21846776_ChIP-Seq_THP-1_Human1.31406074
52SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31350853
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29917601
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25329382
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24283918
56MYB_26560356_Chip-Seq_TH1_Human1.22381689
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21433330
58KDM2B_26808549_Chip-Seq_DND41_Human1.21360149
59MYC_22102868_ChIP-Seq_BL_Human1.20887529
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20254643
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19233288
62* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17868627
63TFEB_21752829_ChIP-Seq_HELA_Human1.16551419
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15243027
65GATA3_26560356_Chip-Seq_TH2_Human1.12221316
66* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11008270
67GATA3_27048872_Chip-Seq_THYMUS_Human1.09369040
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07183029
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07097216
70UTX_26944678_Chip-Seq_JUKART_Human1.05814727
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05769925
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05764135
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05764135
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01495834
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97044810
76ELK3_25401928_ChIP-Seq_HUVEC_Human0.95934976
77TCF7_22412390_ChIP-Seq_EML_Mouse0.93735844
78* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92614647
79TP63_17297297_ChIP-ChIP_HaCaT_Human0.92223112
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90213506
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89356440
82PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87273909
83* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87152673
84SMAD_19615063_ChIP-ChIP_OVARY_Human0.87075337
85GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85980365
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85674531
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85534922
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84882381
89GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84389993
90GATA1_22025678_ChIP-Seq_K562_Human0.84309701
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81957152
92EGR1_19032775_ChIP-ChIP_M12_Human0.81574396
93KDM2B_26808549_Chip-Seq_JURKAT_Human0.81198156
94GATA2_19941826_ChIP-Seq_K562_Human0.79837665
95SMRT_27268052_Chip-Seq_Bcells_Human0.79646690
96GATA1_19941826_ChIP-Seq_K562_Human0.78047195
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77903014
98SOX2_20726797_ChIP-Seq_SW620_Human0.77426191
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76536198
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75437866
101* SPI1_20517297_ChIP-Seq_HL60_Human0.74421396
102KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72769046
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.72322706
104GATA1_19941827_ChIP-Seq_MEL_Mouse0.72165829
105MAF_26560356_Chip-Seq_TH2_Human0.72138281
106RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72099514
107RARG_19884340_ChIP-ChIP_MEFs_Mouse0.71854628
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71634371
109SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.71547613
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.71547613
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71358144
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70876738
113NCOR1_26117541_ChIP-Seq_K562_Human0.70601545
114ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69760925
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.69396486
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.69285603
117IKZF1_21737484_ChIP-ChIP_HCT116_Human0.68968171
118KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.64191369
119STAT1_20625510_ChIP-Seq_HELA_Human0.62653066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.18702080
2MP0003303_peritoneal_inflammation4.12934741
3MP0001835_abnormal_antigen_presentation3.96620303
4MP0009785_altered_susceptibility_to3.73212249
5MP0005058_abnormal_lysosome_morphology3.56036998
6MP0002419_abnormal_innate_immunity3.44627247
7MP0006082_CNS_inflammation3.35107244
8MP0002148_abnormal_hypersensitivity_rea3.24156200
9MP0005000_abnormal_immune_tolerance3.17006384
10MP0003724_increased_susceptibility_to3.00754483
11MP0005025_abnormal_response_to2.91131511
12MP0004510_myositis2.63330316
13MP0002452_abnormal_antigen_presenting2.59362137
14MP0003172_abnormal_lysosome_physiology2.51570374
15MP0005387_immune_system_phenotype2.49585473
16MP0001790_abnormal_immune_system2.49585473
17MP0002723_abnormal_immune_serum2.37247436
18MP0001533_abnormal_skeleton_physiology2.32461133
19MP0001800_abnormal_humoral_immune2.29358477
20MP0005464_abnormal_platelet_physiology2.27041013
21MP0009278_abnormal_bone_marrow2.19489470
22MP0000685_abnormal_immune_system2.14519959
23MP0001819_abnormal_immune_cell2.11581391
24MP0000343_altered_response_to2.10531995
25MP0002420_abnormal_adaptive_immunity2.09212966
26MP0005671_abnormal_response_to2.05426908
27MP0004947_skin_inflammation2.03282132
28MP0003448_altered_tumor_morphology1.95785206
29MP0009764_decreased_sensitivity_to1.92922340
30MP0005451_abnormal_body_composition1.92739101
31MP0001845_abnormal_inflammatory_respons1.92311112
32MP0003075_altered_response_to1.92205955
33MP0002405_respiratory_system_inflammati1.91165080
34MP0005167_abnormal_blood-brain_barrier1.75141995
35MP0000604_amyloidosis1.72853793
36MP0008469_abnormal_protein_level1.70434774
37MP0009840_abnormal_foam_cell1.70007731
38MP0000569_abnormal_digit_pigmentation1.65787019
39MP0003191_abnormal_cellular_cholesterol1.65377007
40MP0001853_heart_inflammation1.64682525
41MP0002998_abnormal_bone_remodeling1.56324663
42MP0002132_abnormal_respiratory_system1.51534644
43MP0009333_abnormal_splenocyte_physiolog1.48922659
44MP0010155_abnormal_intestine_physiology1.47245676
45MP0005310_abnormal_salivary_gland1.45662243
46MP0005166_decreased_susceptibility_to1.45285014
47MP0001545_abnormal_hematopoietic_system1.44357513
48MP0005397_hematopoietic_system_phenotyp1.44357513
49MP0000716_abnormal_immune_system1.43228943
50MP0003690_abnormal_glial_cell1.43172139
51MP0000858_altered_metastatic_potential1.42546560
52MP0003300_gastrointestinal_ulcer1.42293909
53MP0003763_abnormal_thymus_physiology1.36582422
54MP0002006_tumorigenesis1.32978322
55MP0003186_abnormal_redox_activity1.31849377
56MP0008004_abnormal_stomach_pH1.30841215
57MP0003183_abnormal_peptide_metabolism1.29753422
58MP0002398_abnormal_bone_marrow1.28961496
59MP0003828_pulmonary_edema1.28836503
60MP0005164_abnormal_response_to1.27978440
61MP0003195_calcinosis1.27340476
62MP0002277_abnormal_respiratory_mucosa1.23785680
63MP0000689_abnormal_spleen_morphology1.19272971
64MP0002429_abnormal_blood_cell1.14306552
65MP0005076_abnormal_cell_differentiation1.12320434
66MP0003866_abnormal_defecation1.11529095
67MP0005390_skeleton_phenotype1.08054209
68MP0005174_abnormal_tail_pigmentation1.07622391
69MP0004381_abnormal_hair_follicle1.05671522
70MP0003656_abnormal_erythrocyte_physiolo1.05537519
71MP0001851_eye_inflammation1.05472904
72MP0002254_reproductive_system_inflammat1.05234780
73MP0000703_abnormal_thymus_morphology1.03718630
74MP0002722_abnormal_immune_system1.02941311
75MP0003806_abnormal_nucleotide_metabolis1.02580501
76MP0010307_abnormal_tumor_latency1.01914667
77MP0009763_increased_sensitivity_to1.00276430
78MP0002933_joint_inflammation0.97189373
79MP0003566_abnormal_cell_adhesion0.95646547
80MP0008260_abnormal_autophagy0.94983771
81MP0010352_gastrointestinal_tract_polyps0.92225445
82MP0004858_abnormal_nervous_system0.90616165
83MP0005257_abnormal_intraocular_pressure0.90528464
84MP0009765_abnormal_xenobiotic_induced0.90299587
85MP0004782_abnormal_surfactant_physiolog0.88967875
86MP0003453_abnormal_keratinocyte_physiol0.88228550
87MP0002332_abnormal_exercise_endurance0.86990105
88MP0000371_diluted_coat_color0.84112303
89MP0002396_abnormal_hematopoietic_system0.83388850
90MP0000249_abnormal_blood_vessel0.79103139
91MP0002138_abnormal_hepatobiliary_system0.77437211
92MP0005083_abnormal_biliary_tract0.75958584
93MP0003795_abnormal_bone_structure0.75639357
94MP0002166_altered_tumor_susceptibility0.73826066
95MP0000015_abnormal_ear_pigmentation0.71376665
96MP0000465_gastrointestinal_hemorrhage0.69703537
97MP0003045_fibrosis0.69255568
98MP0003091_abnormal_cell_migration0.69246107
99MP0000920_abnormal_myelination0.67205926
100MP0005075_abnormal_melanosome_morpholog0.66753492
101MP0008874_decreased_physiological_sensi0.66429449
102MP0004883_abnormal_blood_vessel0.66175875
103MP0004484_altered_response_of0.65761167
104MP0003705_abnormal_hypodermis_morpholog0.65394802
105MP0005023_abnormal_wound_healing0.64651833
106MP0006054_spinal_hemorrhage0.63587004
107MP0002090_abnormal_vision0.62857352
108MP0002136_abnormal_kidney_physiology0.60560590
109MP0000490_abnormal_crypts_of0.58845591
110MP0008873_increased_physiological_sensi0.57578189
111MP0005376_homeostasis/metabolism_phenot0.56180671
112MP0001663_abnormal_digestive_system0.55945482
113MP0001958_emphysema0.54905184
114MP0004130_abnormal_muscle_cell0.54344556
115MP0000767_abnormal_smooth_muscle0.54052246
116MP0005319_abnormal_enzyme/_coenzyme0.53102972
117MP0004808_abnormal_hematopoietic_stem0.51055171
118MP0002133_abnormal_respiratory_system0.50868295
119MP0005388_respiratory_system_phenotype0.50868295
120MP0003221_abnormal_cardiomyocyte_apopto0.46702824

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.99415459
2Eczematoid dermatitis (HP:0000976)7.35122046
3Recurrent bacterial skin infections (HP:0005406)7.14877994
4Recurrent gram-negative bacterial infections (HP:0005420)6.78126777
5Abnormality of macrophages (HP:0004311)5.79924448
6Increased cerebral lipofuscin (HP:0011813)5.49613301
7Mediastinal lymphadenopathy (HP:0100721)5.15307590
8Increased neuronal autofluorescent lipopigment (HP:0002074)5.11340813
9Stomatitis (HP:0010280)5.00631118
10Vacuolated lymphocytes (HP:0001922)4.87331204
11Gingivitis (HP:0000230)4.36868226
12Obstructive lung disease (HP:0006536)4.33148867
13Chronic obstructive pulmonary disease (HP:0006510)4.33148867
14Systemic lupus erythematosus (HP:0002725)4.30362145
15Elevated erythrocyte sedimentation rate (HP:0003565)4.26223229
16Recurrent skin infections (HP:0001581)4.16340922
17Myositis (HP:0100614)4.11920517
18Orchitis (HP:0100796)4.05398341
19Autoimmune thrombocytopenia (HP:0001973)3.94849290
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.88703040
21Axonal loss (HP:0003447)3.81691747
22Retrobulbar optic neuritis (HP:0100654)3.80515754
23Optic neuritis (HP:0100653)3.80515754
24Disinhibition (HP:0000734)3.76445540
25Encephalitis (HP:0002383)3.73061086
26Abnormality of glycolipid metabolism (HP:0010969)3.65046464
27Abnormality of liposaccharide metabolism (HP:0010968)3.65046464
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.65046464
29Dysostosis multiplex (HP:0000943)3.59889114
30Prostate neoplasm (HP:0100787)3.56893591
31Recurrent fungal infections (HP:0002841)3.51144231
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.43827358
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.28300102
34Episodic fever (HP:0001954)3.24186088
35Urticaria (HP:0001025)3.21689206
36Pustule (HP:0200039)3.13684247
37Thick nail (HP:0001805)3.08057903
38Vasculitis (HP:0002633)3.07736137
39Glomerulonephritis (HP:0000099)3.06373560
40T lymphocytopenia (HP:0005403)3.04933096
41Cellulitis (HP:0100658)3.03387106
42Prolonged bleeding time (HP:0003010)3.01314766
43Gangrene (HP:0100758)2.99685476
44Chest pain (HP:0100749)2.98317333
45Interstitial pulmonary disease (HP:0006530)2.97999732
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.97980882
47Abnormality of T cell number (HP:0011839)2.97281123
48Urinary glycosaminoglycan excretion (HP:0003541)2.95521152
49Mucopolysacchariduria (HP:0008155)2.95521152
50Basal ganglia calcification (HP:0002135)2.94332681
51Agnosia (HP:0010524)2.88026755
52Increased IgE level (HP:0003212)2.86222202
53Periodontitis (HP:0000704)2.81699722
54Tetraparesis (HP:0002273)2.79304359
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.78287475
56Abnormality of polysaccharide metabolism (HP:0011012)2.78287475
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.78287475
58Pulmonary embolism (HP:0002204)2.76344973
59Epistaxis (HP:0000421)2.74093625
60Myocardial infarction (HP:0001658)2.72449285
61Recurrent viral infections (HP:0004429)2.72310921
62Pulmonary infiltrates (HP:0002113)2.65142888
63Loss of speech (HP:0002371)2.55309343
64Leukocytosis (HP:0001974)2.53457999
65Osteomyelitis (HP:0002754)2.53349697
66Meningitis (HP:0001287)2.48743650
67Recurrent pneumonia (HP:0006532)2.46847282
68Hepatosplenomegaly (HP:0001433)2.46692578
69Hematochezia (HP:0002573)2.46229823
70Abnormality of the pleura (HP:0002103)2.42394094
71Abnormality of T cells (HP:0002843)2.41716036
72Inflammation of the large intestine (HP:0002037)2.39552546
73Chronic mucocutaneous candidiasis (HP:0002728)2.38546529
74Recurrent cutaneous fungal infections (HP:0011370)2.38546529
75Increased IgM level (HP:0003496)2.38431025
76Upper motor neuron abnormality (HP:0002127)2.33089142
77Abnormality of the endocardium (HP:0004306)2.32171423
78Granulocytopenia (HP:0001913)2.31127858
79Abnormality of the peritoneum (HP:0002585)2.28571603
80Vertigo (HP:0002321)2.26920778
81Amyloidosis (HP:0011034)2.25691093
82Vertebral compression fractures (HP:0002953)2.25105944
83Gastrointestinal inflammation (HP:0004386)2.22778819
84Bone pain (HP:0002653)2.22576403
85Arterial thrombosis (HP:0004420)2.22505218
86J-shaped sella turcica (HP:0002680)2.18447552
87Glomerulopathy (HP:0100820)2.17934753
88Hypochromic microcytic anemia (HP:0004840)2.17838039
89Colitis (HP:0002583)2.17052050
90Eosinophilia (HP:0001880)2.16840133
91Keratoconjunctivitis sicca (HP:0001097)2.15733265
92Pathologic fracture (HP:0002756)2.14915971
93Keratitis (HP:0000491)2.14197360
94Hypochromic anemia (HP:0001931)2.11800803
95Esophageal neoplasm (HP:0100751)2.10386195
96Neoplasm of head and neck (HP:0012288)2.10386195
97Nephritis (HP:0000123)2.09930607
98Petechiae (HP:0000967)2.09658515
99Panhypogammaglobulinemia (HP:0003139)2.08815784
100Nausea (HP:0002018)2.07983995
101Gingival bleeding (HP:0000225)2.07189327
102Hemoptysis (HP:0002105)2.06494997
103Recurrent lower respiratory tract infections (HP:0002783)2.05902768
104Slow saccadic eye movements (HP:0000514)2.05478426
105Polyneuropathy (HP:0001271)2.05373886
106Acne (HP:0001061)2.04477056
107Viral hepatitis (HP:0006562)2.04267483
108Abnormality of the prostate (HP:0008775)2.03225299
109Abnormality of T cell physiology (HP:0011840)2.02658911
110Thrombophlebitis (HP:0004418)1.99853867
111Diminished motivation (HP:0000745)1.99568434
112Apathy (HP:0000741)1.97823355
113Increased serum ferritin (HP:0003281)1.97082707
114Abnormality of the vasculature of the conjunctiva (HP:0008054)1.96741946
115Acute hepatic failure (HP:0006554)1.96060073
116Osteolytic defects of the hand bones (HP:0009699)1.94991399
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.94991399
118Purpura (HP:0000979)1.94930219
119Keratoconjunctivitis (HP:0001096)1.93968146
120Premature loss of primary teeth (HP:0006323)1.92739092
121Poor head control (HP:0002421)1.92601412
122Hypergammaglobulinemia (HP:0010702)1.92593002
123Progressive visual loss (HP:0000529)1.91818422
124Inappropriate behavior (HP:0000719)1.90023794
125Skin ulcer (HP:0200042)1.89502991
126Abnormality of iron homeostasis (HP:0011031)1.89428986
127Peritonitis (HP:0002586)1.87836252
128Sepsis (HP:0100806)1.87507396
129Abnormal platelet volume (HP:0011876)1.86669241
130Peripheral demyelination (HP:0011096)1.86575399
131Spontaneous hematomas (HP:0007420)1.85805881
132Cheilitis (HP:0100825)1.85435076
133Abnormality of the lumbar spine (HP:0100712)1.85309627
134Chronic otitis media (HP:0000389)1.84694597
135Autoimmune hemolytic anemia (HP:0001890)1.83950432
136Anorexia (HP:0002039)1.83153410
137Subacute progressive viral hepatitis (HP:0006572)1.82759983
138Abnormality of the pericardium (HP:0001697)1.82222506
139Albinism (HP:0001022)1.81592650
140Gastrointestinal infarctions (HP:0005244)1.80954454
141Amaurosis fugax (HP:0100576)1.77658026
142Microcytic anemia (HP:0001935)1.77514492
143Joint hemorrhage (HP:0005261)1.77216755
144Arthralgia (HP:0002829)1.76704671
145Difficulty running (HP:0009046)1.76663468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.84239912
2MAP3K144.16737903
3PBK3.96221136
4TBK13.87890364
5IRAK33.55831613
6BLK3.53054322
7IRAK43.33934586
8TYK22.79442902
9KIT2.48689316
10IKBKE2.45363647
11IKBKB2.27565559
12MAP4K12.26379962
13ERN12.20276424
14TXK1.98587535
15PRPF4B1.95426005
16TAOK11.94441837
17MAP3K61.81647162
18PIM21.80128246
19FGR1.71519007
20CSK1.70057444
21JAK31.68722457
22JAK11.66797987
23TNK21.61241449
24MAP3K131.49173094
25NME21.44647001
26CSF1R1.38194127
27HCK1.37723518
28ZAP701.36564621
29SYK1.36437349
30MATK1.35824183
31FES1.35451731
32RPS6KA41.33218396
33LYN1.27987571
34ABL21.27316229
35CHUK1.26818896
36MST1R1.26657084
37EPHB11.25448895
38MARK31.17830397
39PIK3CG1.17282883
40MAP3K21.15902285
41BMX1.14504740
42MAP2K41.11452711
43LCK1.09032093
44JAK21.08672241
45TAOK31.08129659
46PIM11.07171539
47BTK1.02742747
48NEK90.95721282
49ERBB40.95443554
50MAP2K30.92187606
51STK100.89334317
52MAP3K110.88771299
53TEC0.87969777
54STK40.84458233
55EGFR0.83202376
56MST40.83001957
57TGFBR20.82578913
58PRKCD0.82541923
59MARK20.82534396
60MAP2K60.80041875
61MAP3K50.79926834
62ACVR1B0.78818320
63BMPR20.77489792
64ABL10.75143209
65ARAF0.74885495
66CLK10.73081594
67KSR20.71089571
68MAP3K30.70231599
69SIK20.68968682
70KSR10.68859121
71YES10.67608744
72GRK70.66451046
73PTK2B0.66440887
74RIPK10.64840658
75MAP3K10.63965479
76LRRK20.61254887
77PTK60.61122399
78STK110.59280598
79TRPM70.57714382
80TTN0.57666266
81EIF2AK20.57297295
82SGK30.55723265
83PRKG20.51914866
84RET0.51226323
85FGFR30.50888416
86TRIB30.50728216
87SGK20.50079337
88SCYL20.48879116
89CDC42BPA0.47148126
90CDK190.46773690
91MOS0.46569227
92PRKD20.46309849
93CAMK1D0.46182161
94FYN0.46141443
95DYRK30.45858565
96WNK10.45666799
97IRAK20.45486370
98ITK0.44403378
99HIPK20.43857725
100MAPK70.42950098
101ALK0.42667271
102CDK60.41827484
103MAPK120.40725884
104IRAK10.40673269
105DYRK1B0.40396512
106ERBB30.40061873
107STK30.39715216
108PKN20.37994912
109PDPK10.37526797
110MAP3K70.35085832
111NLK0.34518331
112PAK40.34219682
113GRK60.34167267
114CAMKK20.34125714
115DAPK30.34053351
116SIK30.33997475
117TESK20.32667226
118TAOK20.31773513
119RPS6KA60.31710827
120RPS6KC10.31206999
121RPS6KL10.31206999
122MAPKAPK20.30110351
123MELK0.28484758
124PDK10.28335959
125DAPK20.27572659
126EPHA30.27264396
127PRKCZ0.25626876
128CAMK40.25571027
129TESK10.24841974
130FGFR40.23525596
131RAF10.23067982
132MAPK40.22092295
133PDGFRB0.21682443

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.63354116
2Staphylococcus aureus infection_Homo sapiens_hsa051503.62053213
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.86940503
4Legionellosis_Homo sapiens_hsa051342.81331074
5Graft-versus-host disease_Homo sapiens_hsa053322.81096748
6Osteoclast differentiation_Homo sapiens_hsa043802.58010329
7Malaria_Homo sapiens_hsa051442.50462843
8Tuberculosis_Homo sapiens_hsa051522.50306130
9Pertussis_Homo sapiens_hsa051332.48024288
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.46254070
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.46073069
12Lysosome_Homo sapiens_hsa041422.45139698
13Rheumatoid arthritis_Homo sapiens_hsa053232.37792126
14Phagosome_Homo sapiens_hsa041452.18417654
15Asthma_Homo sapiens_hsa053102.10097183
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.99849363
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97802401
18Allograft rejection_Homo sapiens_hsa053301.94648217
19Salmonella infection_Homo sapiens_hsa051321.94147246
20TNF signaling pathway_Homo sapiens_hsa046681.88899553
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86333683
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84963267
23Measles_Homo sapiens_hsa051621.76695320
24Other glycan degradation_Homo sapiens_hsa005111.63527613
25Type I diabetes mellitus_Homo sapiens_hsa049401.62943797
26B cell receptor signaling pathway_Homo sapiens_hsa046621.61270829
27Influenza A_Homo sapiens_hsa051641.60562529
28Hematopoietic cell lineage_Homo sapiens_hsa046401.60243560
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.57146253
30African trypanosomiasis_Homo sapiens_hsa051431.48236957
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45496523
32Toxoplasmosis_Homo sapiens_hsa051451.43724647
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41591498
34Shigellosis_Homo sapiens_hsa051311.38921503
35Apoptosis_Homo sapiens_hsa042101.32728905
36Chemokine signaling pathway_Homo sapiens_hsa040621.28128985
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.24143201
38Herpes simplex infection_Homo sapiens_hsa051681.23310024
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19302341
40Antigen processing and presentation_Homo sapiens_hsa046121.15901897
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15283118
42Non-small cell lung cancer_Homo sapiens_hsa052231.11717731
43Amoebiasis_Homo sapiens_hsa051461.09703253
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09679409
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.04246054
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02661292
47Hepatitis B_Homo sapiens_hsa051611.01299558
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97369851
49Collecting duct acid secretion_Homo sapiens_hsa049660.95613473
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94092013
51Hepatitis C_Homo sapiens_hsa051600.90818702
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.89140643
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87210799
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87095537
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85977759
56Complement and coagulation cascades_Homo sapiens_hsa046100.83628524
57Mineral absorption_Homo sapiens_hsa049780.81864604
58Viral myocarditis_Homo sapiens_hsa054160.80604404
59Prion diseases_Homo sapiens_hsa050200.80318128
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77640465
61Acute myeloid leukemia_Homo sapiens_hsa052210.69096991
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69087422
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.67290631
64T cell receptor signaling pathway_Homo sapiens_hsa046600.66737010
65Autoimmune thyroid disease_Homo sapiens_hsa053200.64882115
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.62108346
67GnRH signaling pathway_Homo sapiens_hsa049120.61908544
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.61552416
69Chronic myeloid leukemia_Homo sapiens_hsa052200.61439861
70Sphingolipid metabolism_Homo sapiens_hsa006000.60235151
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.60057184
72Pancreatic cancer_Homo sapiens_hsa052120.58502159
73Platelet activation_Homo sapiens_hsa046110.55288967
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55217452
75Endometrial cancer_Homo sapiens_hsa052130.54006527
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53659961
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52365150
78HIF-1 signaling pathway_Homo sapiens_hsa040660.50695846
79Epstein-Barr virus infection_Homo sapiens_hsa051690.48458532
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47300895
81Caffeine metabolism_Homo sapiens_hsa002320.46195717
82Choline metabolism in cancer_Homo sapiens_hsa052310.46059698
83Type II diabetes mellitus_Homo sapiens_hsa049300.45034782
84ErbB signaling pathway_Homo sapiens_hsa040120.44857771
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42481523
86VEGF signaling pathway_Homo sapiens_hsa043700.41631891
87Bladder cancer_Homo sapiens_hsa052190.41241619
88Prolactin signaling pathway_Homo sapiens_hsa049170.40496078
89Endocytosis_Homo sapiens_hsa041440.40313538
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39974053
91Glioma_Homo sapiens_hsa052140.38952229
92Primary immunodeficiency_Homo sapiens_hsa053400.38937249
93Prostate cancer_Homo sapiens_hsa052150.37122398
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36758920
95Inositol phosphate metabolism_Homo sapiens_hsa005620.36658904
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36187124
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36137306
98Dorso-ventral axis formation_Homo sapiens_hsa043200.35928849
99Rap1 signaling pathway_Homo sapiens_hsa040150.35624561
100Proteoglycans in cancer_Homo sapiens_hsa052050.35431851
101Regulation of autophagy_Homo sapiens_hsa041400.33514408
102Estrogen signaling pathway_Homo sapiens_hsa049150.33445565
103Small cell lung cancer_Homo sapiens_hsa052220.31820395
104Vibrio cholerae infection_Homo sapiens_hsa051100.31650811
105Viral carcinogenesis_Homo sapiens_hsa052030.30284835
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29767965
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26516061
108Insulin resistance_Homo sapiens_hsa049310.23351231
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21533618
110Renal cell carcinoma_Homo sapiens_hsa052110.21502257
111Renin-angiotensin system_Homo sapiens_hsa046140.19206693
112Notch signaling pathway_Homo sapiens_hsa043300.19065311
113FoxO signaling pathway_Homo sapiens_hsa040680.17411710
114MicroRNAs in cancer_Homo sapiens_hsa052060.15993454
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14568732
116mTOR signaling pathway_Homo sapiens_hsa041500.13688244
117HTLV-I infection_Homo sapiens_hsa051660.12647500
118MAPK signaling pathway_Homo sapiens_hsa040100.12205498

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »