CLEC3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1notochord development (GO:0030903)9.22919766
2negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)9.22758031
3limb bud formation (GO:0060174)8.97671150
4positive regulation of extracellular matrix organization (GO:1903055)8.07642288
5collagen fibril organization (GO:0030199)7.55020384
6sphingomyelin metabolic process (GO:0006684)7.08950672
7cartilage development (GO:0051216)6.86310317
8proteoglycan metabolic process (GO:0006029)6.80258689
9embryonic skeletal joint morphogenesis (GO:0060272)6.59522415
10chondroitin sulfate biosynthetic process (GO:0030206)6.35240667
11replacement ossification (GO:0036075)6.05642109
12endochondral ossification (GO:0001958)6.05642109
13behavioral response to nicotine (GO:0035095)5.90374279
14chondrocyte differentiation (GO:0002062)5.87622441
15positive regulation of chondrocyte differentiation (GO:0032332)5.65198234
16nucleotide-sugar biosynthetic process (GO:0009226)5.57949849
17endothelial cell morphogenesis (GO:0001886)5.53325612
18keratan sulfate biosynthetic process (GO:0018146)5.50821473
19regulation of extracellular matrix disassembly (GO:0010715)5.45040363
20protein retention in ER lumen (GO:0006621)5.10980981
21collagen catabolic process (GO:0030574)5.08971436
22lipopolysaccharide biosynthetic process (GO:0009103)4.99995056
23cellular glucuronidation (GO:0052695)4.99804242
24negative regulation of gluconeogenesis (GO:0045721)4.93221372
25regulation of extracellular matrix organization (GO:1903053)4.86115146
26positive regulation of cartilage development (GO:0061036)4.84304295
27collagen metabolic process (GO:0032963)4.82006124
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.72451454
29* skeletal system development (GO:0001501)4.72353931
30hypotonic response (GO:0006971)4.69304441
31multicellular organismal catabolic process (GO:0044243)4.65639164
32regulation of plasminogen activation (GO:0010755)4.54957352
33uronic acid metabolic process (GO:0006063)4.51313316
34glucuronate metabolic process (GO:0019585)4.51313316
35multicellular organismal macromolecule metabolic process (GO:0044259)4.50246515
36iron ion import (GO:0097286)4.49225832
37keratan sulfate metabolic process (GO:0042339)4.44233541
38response to pheromone (GO:0019236)4.41911798
39cellular response to BMP stimulus (GO:0071773)4.34624430
40response to BMP (GO:0071772)4.34624430
41glycoprotein metabolic process (GO:0009100)4.30197634
42multicellular organismal metabolic process (GO:0044236)4.28278743
43peptidyl-proline hydroxylation (GO:0019511)4.24498058
44lipopolysaccharide metabolic process (GO:0008653)4.23026182
45connective tissue development (GO:0061448)4.17615603
46positive regulation of hormone biosynthetic process (GO:0046886)4.09381199
47glycosaminoglycan biosynthetic process (GO:0006024)4.05288276
48endocardial cushion morphogenesis (GO:0003203)4.02976335
49aminoglycan biosynthetic process (GO:0006023)3.99209814
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.98375269
51extracellular matrix disassembly (GO:0022617)3.94782456
52regulation of chondrocyte differentiation (GO:0032330)3.92102278
53regulation of response to osmotic stress (GO:0047484)3.89984932
54myelin assembly (GO:0032288)3.83896526
55short-term memory (GO:0007614)3.82151175
56chondroitin sulfate metabolic process (GO:0030204)3.75918563
57UDP-N-acetylglucosamine metabolic process (GO:0006047)3.75170093
58regulation of cartilage development (GO:0061035)3.72020590
59proteoglycan biosynthetic process (GO:0030166)3.70530500
60embryonic viscerocranium morphogenesis (GO:0048703)3.66868872
61negative regulation of smooth muscle cell differentiation (GO:0051151)3.64427871
62response to gravity (GO:0009629)3.57385608
63chondrocyte proliferation (GO:0035988)3.57323977
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.55076927
65glycosaminoglycan catabolic process (GO:0006027)3.53514502
66sulfur compound catabolic process (GO:0044273)3.52968036
67indole-containing compound catabolic process (GO:0042436)3.52569975
68indolalkylamine catabolic process (GO:0046218)3.52569975
69tryptophan catabolic process (GO:0006569)3.52569975
70ossification (GO:0001503)3.49803421
71L-fucose catabolic process (GO:0042355)3.48017674
72fucose catabolic process (GO:0019317)3.48017674
73L-fucose metabolic process (GO:0042354)3.48017674
74COPII vesicle coating (GO:0048208)3.47608630
75kynurenine metabolic process (GO:0070189)3.42223147
76regulation of type B pancreatic cell apoptotic process (GO:2000674)3.38378539
77regulation of steroid hormone biosynthetic process (GO:0090030)3.37470782
78aminoglycan catabolic process (GO:0006026)3.34071932
79indolalkylamine metabolic process (GO:0006586)3.33960912
80nonmotile primary cilium assembly (GO:0035058)3.33015019
81negative regulation of chemokine production (GO:0032682)3.32657092
82hyperosmotic salinity response (GO:0042538)3.32162864
83negative regulation of cartilage development (GO:0061037)3.30774413
84cornea development in camera-type eye (GO:0061303)3.29434427
85protein hydroxylation (GO:0018126)3.29195627
86nucleotide-sugar metabolic process (GO:0009225)3.29091683
87epithelial cilium movement (GO:0003351)3.26871812
88Golgi transport vesicle coating (GO:0048200)3.25561088
89COPI coating of Golgi vesicle (GO:0048205)3.25561088
90extracellular matrix organization (GO:0030198)3.22851121
91extracellular structure organization (GO:0043062)3.21932991
92multicellular organism reproduction (GO:0032504)3.18797478
93ubiquinone biosynthetic process (GO:0006744)3.17682987
94water-soluble vitamin biosynthetic process (GO:0042364)3.15877828
95pyrimidine nucleobase catabolic process (GO:0006208)3.15730761
96mesenchyme morphogenesis (GO:0072132)3.14789677
97regulation of bone mineralization (GO:0030500)3.13900013
98detection of light stimulus involved in sensory perception (GO:0050962)3.12441090
99detection of light stimulus involved in visual perception (GO:0050908)3.12441090
100endodermal cell differentiation (GO:0035987)3.11075569
101type B pancreatic cell development (GO:0003323)3.09698019
102platelet dense granule organization (GO:0060155)3.08362111
103retina layer formation (GO:0010842)3.08328767
104otic vesicle formation (GO:0030916)3.08032759
105mucopolysaccharide metabolic process (GO:1903510)3.06955710
106bone development (GO:0060348)3.04405644
107negative regulation of NF-kappaB import into nucleus (GO:0042347)3.01888949
108regulation of action potential (GO:0098900)3.01425467
109negative regulation of endothelial cell proliferation (GO:0001937)3.01060004
110sulfation (GO:0051923)3.00103896
111preassembly of GPI anchor in ER membrane (GO:0016254)2.99983696
112DNA deamination (GO:0045006)2.97306147
113positive regulation of hormone metabolic process (GO:0032352)2.96816504
114positive regulation of endothelial cell differentiation (GO:0045603)2.96553766
115protein polyglutamylation (GO:0018095)2.96478272
116mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95583292
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.95583292
118NADH dehydrogenase complex assembly (GO:0010257)2.95583292
119glycoprotein biosynthetic process (GO:0009101)2.95347495
120protein complex biogenesis (GO:0070271)2.94490803
121kidney morphogenesis (GO:0060993)2.94312834
122negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.93080223
123ubiquinone metabolic process (GO:0006743)2.92771121
124regulation of cell maturation (GO:1903429)2.91944757
125regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.91807277
126regulation of energy homeostasis (GO:2000505)2.91608186
127negative regulation of chondrocyte differentiation (GO:0032331)2.90330829
128neural tube formation (GO:0001841)2.90319126
129negative regulation of glycogen biosynthetic process (GO:0045719)2.89876344
130synaptic transmission, cholinergic (GO:0007271)2.89171927
131regulation of hexokinase activity (GO:1903299)2.88139818
132regulation of glucokinase activity (GO:0033131)2.88139818
133protein K11-linked deubiquitination (GO:0035871)2.81441675
134cilium morphogenesis (GO:0060271)2.81359508
135negative regulation of telomere maintenance (GO:0032205)2.81332686
136protein localization to cilium (GO:0061512)2.80915031
137cardiac right ventricle morphogenesis (GO:0003215)2.79236960
138regulation of memory T cell differentiation (GO:0043380)2.78916689
139mitochondrial respiratory chain complex assembly (GO:0033108)2.78595998
140reflex (GO:0060004)2.76634639
141cellular ketone body metabolic process (GO:0046950)2.75621914
142cellular biogenic amine catabolic process (GO:0042402)2.73537383
143amine catabolic process (GO:0009310)2.73537383
144regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72877168
145hindbrain development (GO:0030902)2.72393624
146intraciliary transport (GO:0042073)2.71761211
147replication fork processing (GO:0031297)2.71611769
148nucleobase catabolic process (GO:0046113)2.71431908
149neuronal action potential (GO:0019228)2.71250789
150piRNA metabolic process (GO:0034587)2.71130422
151tryptophan metabolic process (GO:0006568)2.69685354
152respiratory chain complex IV assembly (GO:0008535)2.68312419
153behavioral response to ethanol (GO:0048149)2.66002093
154startle response (GO:0001964)2.65195705
155mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.63910779
156protein K6-linked ubiquitination (GO:0085020)2.63480980
157photoreceptor cell maintenance (GO:0045494)2.62922798
158negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62677546
159keratinocyte development (GO:0003334)2.62355118
160protein-cofactor linkage (GO:0018065)2.58315554
161regulation of neurotransmitter uptake (GO:0051580)2.57670655
162regulation of cilium movement (GO:0003352)2.57482057
163adaptation of signaling pathway (GO:0023058)2.57050815
164axoneme assembly (GO:0035082)2.55405779
165positive regulation of gastrulation (GO:2000543)2.55389428
166ketone body metabolic process (GO:1902224)2.53062028
167photoreceptor cell development (GO:0042461)2.51699456
168reciprocal meiotic recombination (GO:0007131)2.50855919
169reciprocal DNA recombination (GO:0035825)2.50855919
170intestinal epithelial cell development (GO:0060576)2.50577689
171DNA methylation involved in gamete generation (GO:0043046)2.50531773
172S-adenosylmethionine metabolic process (GO:0046500)2.48946155
173indole-containing compound metabolic process (GO:0042430)2.46636136
174quinone biosynthetic process (GO:1901663)2.46351195
175cilium organization (GO:0044782)2.46152220
176protein import into peroxisome matrix (GO:0016558)2.46134017
177mannosylation (GO:0097502)2.44780731
178phosphatidylinositol acyl-chain remodeling (GO:0036149)2.43469372
179gamma-aminobutyric acid transport (GO:0015812)2.41691255
180GPI anchor metabolic process (GO:0006505)2.40907583
181somite rostral/caudal axis specification (GO:0032525)2.40347089
182embryonic epithelial tube formation (GO:0001838)2.39628497
183purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.39392886
1843-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.39392886
185RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.38872543
186tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.38872543
187cilium assembly (GO:0042384)2.38512134
188positive regulation of oligodendrocyte differentiation (GO:0048714)2.37553024
189cilium movement (GO:0003341)2.36964176
190positive regulation of fatty acid oxidation (GO:0046321)2.36450092
191protein neddylation (GO:0045116)2.34173610
192cytochrome complex assembly (GO:0017004)2.32419054
193left/right axis specification (GO:0070986)2.32328819
194cartilage development involved in endochondral bone morphogenesis (GO:0060351)14.0680324
195cartilage condensation (GO:0001502)12.5450299
196cell aggregation (GO:0098743)12.5450299
197chondrocyte development (GO:0002063)12.0550038
198keratan sulfate catabolic process (GO:0042340)11.1906244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.19353508
2AR_21572438_ChIP-Seq_LNCaP_Human5.89899789
3GATA1_22025678_ChIP-Seq_K562_Human5.18314452
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.18766511
5ZNF274_21170338_ChIP-Seq_K562_Hela4.08131974
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.54631413
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.20904564
8VDR_22108803_ChIP-Seq_LS180_Human2.64090777
9EZH2_22144423_ChIP-Seq_EOC_Human2.59403215
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54074474
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.40164204
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.32977707
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29328281
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.28606534
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26175498
16ER_23166858_ChIP-Seq_MCF-7_Human2.23833120
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22020331
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18807429
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17510589
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14033338
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.11832863
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11557396
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.10189291
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.09446938
25IGF1R_20145208_ChIP-Seq_DFB_Human2.04534742
26CJUN_26792858_Chip-Seq_BT549_Human2.03706675
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.02369777
28IRF1_19129219_ChIP-ChIP_H3396_Human1.96950732
29EWS_26573619_Chip-Seq_HEK293_Human1.96771159
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96471059
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.94252458
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85893881
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82694892
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81523011
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.74483803
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72921149
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.72891826
38FUS_26573619_Chip-Seq_HEK293_Human1.70608296
39TP53_22573176_ChIP-Seq_HFKS_Human1.70475736
40P300_19829295_ChIP-Seq_ESCs_Human1.70137574
41TAF15_26573619_Chip-Seq_HEK293_Human1.68987212
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.65089338
43RXR_22108803_ChIP-Seq_LS180_Human1.64579029
44TP53_18474530_ChIP-ChIP_U2OS_Human1.64182603
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60348133
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60167817
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59804189
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.59783245
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58833540
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.57917647
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.57354049
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.56720291
53REST_21632747_ChIP-Seq_MESCs_Mouse1.53319440
54AHR_22903824_ChIP-Seq_MCF-7_Human1.51168362
55* AR_25329375_ChIP-Seq_VCAP_Human1.50821564
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47843465
57JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46639263
58* HOXB7_26014856_ChIP-Seq_BT474_Human1.44306224
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.40969929
60BCAT_22108803_ChIP-Seq_LS180_Human1.40611589
61VDR_24787735_ChIP-Seq_THP-1_Human1.40463811
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39771417
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39723937
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39359253
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39359253
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38892337
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38599563
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38599563
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36834379
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36416350
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.34836727
72SMAD4_21799915_ChIP-Seq_A2780_Human1.34447392
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33646442
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33646442
75STAT3_23295773_ChIP-Seq_U87_Human1.33591148
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33474384
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.33474384
78TCF4_23295773_ChIP-Seq_U87_Human1.33226617
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32192774
80CBP_20019798_ChIP-Seq_JUKART_Human1.31973028
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31973028
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31525209
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31132969
84* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30751202
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30687503
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.28812288
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28127207
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27908083
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27557631
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.26923648
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26912683
92SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25723706
93GATA3_24758297_ChIP-Seq_MCF-7_Human1.25234084
94* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24350872
95* SOX2_20726797_ChIP-Seq_SW620_Human1.24240945
96RUNX2_22187159_ChIP-Seq_PCA_Human1.24051283
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23588389
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22632267
99MYC_18940864_ChIP-ChIP_HL60_Human1.22492357
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.22467407
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22263092
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.21878427
103RNF2_27304074_Chip-Seq_NSC_Mouse1.21470137
104AR_20517297_ChIP-Seq_VCAP_Human1.20651848
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.20508744
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.19785457
107ELK1_19687146_ChIP-ChIP_HELA_Human1.19356155
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19211995
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17062329
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16639138
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15372915
112TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15181291
113KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14646217
114ESR1_20079471_ChIP-ChIP_T-47D_Human1.14514257
115STAT3_18555785_Chip-Seq_ESCs_Mouse1.14150054
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13718174
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12989153
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11868900
119SA1_22415368_ChIP-Seq_MEFs_Mouse1.10148995
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09684937
121ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08306546
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08260260
123* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07988167
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07331119
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06937989
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06816671
127RNF2_27304074_Chip-Seq_ESCs_Mouse1.06411374
128TP63_19390658_ChIP-ChIP_HaCaT_Human1.06273785
129ERA_21632823_ChIP-Seq_H3396_Human1.05701371
130* NCOR_22424771_ChIP-Seq_293T_Human1.05524869
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04355893
132SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04071853
133BRD4_25478319_ChIP-Seq_HGPS_Human1.02622324
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02532948
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01909988
136ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01103351
137SOX2_19829295_ChIP-Seq_ESCs_Human1.00603611
138NANOG_19829295_ChIP-Seq_ESCs_Human1.00603611
139PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99736031
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.99223305
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.98428328
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98245439
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97123130
144BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96812914
145KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96652226
146PIAS1_25552417_ChIP-Seq_VCAP_Human0.96446985
147EGR1_19032775_ChIP-ChIP_M12_Human0.95803886
148NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94234130
149NANOG_18555785_Chip-Seq_ESCs_Mouse0.92996991
150SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92814245
151MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92564802
152TP53_20018659_ChIP-ChIP_R1E_Mouse0.91933870
153SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91892224
154SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91892224
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.91413139
156CLOCK_20551151_ChIP-Seq_293T_Human0.90908211
157SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90610685
158CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90306900
159NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89934311
160TCF4_22108803_ChIP-Seq_LS180_Human0.89092083
161* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88608331
162TBX20_22080862_ChIP-Seq_HEART_Mouse0.87622809
163TBX20_22328084_ChIP-Seq_HEART_Mouse0.87622809
164P53_22387025_ChIP-Seq_ESCs_Mouse0.86919531
165CTCF_21964334_Chip-Seq_Bcells_Human0.86488156
166GBX2_23144817_ChIP-Seq_PC3_Human0.85546378
167TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84629375
168NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84142612
169TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83184865
170SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.83070749
171ERG_21242973_ChIP-ChIP_JURKAT_Human0.82911750
172CTBP1_25329375_ChIP-Seq_LNCAP_Human0.82028358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004134_abnormal_chest_morphology6.34634494
2MP0002933_joint_inflammation5.90630981
3MP0002282_abnormal_trachea_morphology5.71029585
4MP0003646_muscle_fatigue4.86215015
5MP0005503_abnormal_tendon_morphology4.60220844
6MP0000163_abnormal_cartilage_morphology4.28239062
7MP0009250_abnormal_appendicular_skeleto4.13224253
8MP0009780_abnormal_chondrocyte_physiolo3.63921967
9MP0002115_abnormal_skeleton_extremities3.50011151
10MP0008877_abnormal_DNA_methylation3.10538909
11MP0002089_abnormal_postnatal_growth/wei2.99224998
12MP0002113_abnormal_skeleton_development2.93149645
13MP0002896_abnormal_bone_mineralization2.79153876
14MP0001299_abnormal_eye_distance/2.67631081
15MP0000569_abnormal_digit_pigmentation2.65498772
16MP0000762_abnormal_tongue_morphology2.65446952
17MP0002909_abnormal_adrenal_gland2.60854706
18MP0005551_abnormal_eye_electrophysiolog2.50747873
19MP0001533_abnormal_skeleton_physiology2.50308241
20MP0003283_abnormal_digestive_organ2.49802024
21MP0001270_distended_abdomen2.47408445
22MP0003123_paternal_imprinting2.39127716
23MP0005390_skeleton_phenotype2.37373068
24MP0005508_abnormal_skeleton_morphology2.29367304
25MP0002109_abnormal_limb_morphology2.27486188
26MP0008875_abnormal_xenobiotic_pharmacok2.25618917
27MP0004885_abnormal_endolymph2.19598357
28MP0000751_myopathy2.01091648
29MP0006072_abnormal_retinal_apoptosis2.00472131
30MP0001968_abnormal_touch/_nociception1.99039849
31MP0002102_abnormal_ear_morphology1.96926560
32MP0002638_abnormal_pupillary_reflex1.96747326
33MP0003795_abnormal_bone_structure1.92982066
34MP0000427_abnormal_hair_cycle1.92945630
35MP0003880_abnormal_central_pattern1.87556107
36MP0006292_abnormal_olfactory_placode1.86256861
37MP0001542_abnormal_bone_strength1.77638373
38MP0001485_abnormal_pinna_reflex1.76359319
39MP0004133_heterotaxia1.75407699
40MP0002876_abnormal_thyroid_physiology1.72071744
41MP0000372_irregular_coat_pigmentation1.71554659
42MP0008872_abnormal_physiological_respon1.70455554
43MP0002116_abnormal_craniofacial_bone1.69882763
44MP0002653_abnormal_ependyma_morphology1.67765451
45MP0003755_abnormal_palate_morphology1.66281304
46MP0003656_abnormal_erythrocyte_physiolo1.66159053
47MP0001529_abnormal_vocalization1.63624420
48MP0009745_abnormal_behavioral_response1.61501540
49MP0005645_abnormal_hypothalamus_physiol1.61247746
50MP0004147_increased_porphyrin_level1.60774652
51MP0005253_abnormal_eye_physiology1.60773003
52MP0003136_yellow_coat_color1.60095392
53MP0000049_abnormal_middle_ear1.57911845
54MP0003011_delayed_dark_adaptation1.55631905
55MP0009384_cardiac_valve_regurgitation1.53489157
56MP0003195_calcinosis1.53393112
57MP0002108_abnormal_muscle_morphology1.53346964
58MP0002736_abnormal_nociception_after1.52585366
59MP0002837_dystrophic_cardiac_calcinosis1.50462061
60MP0000631_abnormal_neuroendocrine_gland1.50367661
61MP0002163_abnormal_gland_morphology1.47079934
62MP0006276_abnormal_autonomic_nervous1.46815622
63MP0004742_abnormal_vestibular_system1.45491629
64MP0000383_abnormal_hair_follicle1.40084771
65MP0002249_abnormal_larynx_morphology1.39539266
66MP0008438_abnormal_cutaneous_collagen1.39492575
67MP0001905_abnormal_dopamine_level1.35813134
68MP0001984_abnormal_olfaction1.35204571
69MP0002272_abnormal_nervous_system1.35171212
70MP0004272_abnormal_basement_membrane1.34181184
71MP0009046_muscle_twitch1.33041798
72MP0000432_abnormal_head_morphology1.32488889
73MP0003787_abnormal_imprinting1.32485213
74MP0005423_abnormal_somatic_nervous1.31993417
75MP0002751_abnormal_autonomic_nervous1.31001928
76MP0002998_abnormal_bone_remodeling1.29336987
77MP0004142_abnormal_muscle_tone1.29229785
78MP0003436_decreased_susceptibility_to1.28873693
79MP0002277_abnormal_respiratory_mucosa1.28669893
80MP0002233_abnormal_nose_morphology1.28590965
81MP0001486_abnormal_startle_reflex1.28542567
82MP0004264_abnormal_extraembryonic_tissu1.26740621
83MP0002557_abnormal_social/conspecific_i1.26336740
84MP0005195_abnormal_posterior_eye1.24045272
85MP0001986_abnormal_taste_sensitivity1.23310336
86MP0004043_abnormal_pH_regulation1.22988130
87MP0008789_abnormal_olfactory_epithelium1.22218277
88MP0002111_abnormal_tail_morphology1.20272736
89MP0003890_abnormal_embryonic-extraembry1.18707651
90MP0002938_white_spotting1.18101369
91MP0003122_maternal_imprinting1.17294272
92MP0009697_abnormal_copulation1.16228481
93MP0008004_abnormal_stomach_pH1.15478101
94MP0002160_abnormal_reproductive_system1.14350606
95MP0002114_abnormal_axial_skeleton1.13659982
96MP0005381_digestive/alimentary_phenotyp1.13658838
97MP0005275_abnormal_skin_tensile1.12798413
98MP0005075_abnormal_melanosome_morpholog1.11923111
99MP0001663_abnormal_digestive_system1.10681132
100MP0003718_maternal_effect1.10654743
101MP0002572_abnormal_emotion/affect_behav1.10297881
102MP0000778_abnormal_nervous_system1.09863933
103MP0003878_abnormal_ear_physiology1.09334026
104MP0005377_hearing/vestibular/ear_phenot1.09334026
105MP0003937_abnormal_limbs/digits/tail_de1.08027505
106MP0005386_behavior/neurological_phenoty1.07387611
107MP0004924_abnormal_behavior1.07387611
108MP0001970_abnormal_pain_threshold1.07136756
109MP0003279_aneurysm1.06760606
110MP0001919_abnormal_reproductive_system1.05314891
111MP0000647_abnormal_sebaceous_gland1.04752036
112MP0005389_reproductive_system_phenotype1.03610251
113MP0002752_abnormal_somatic_nervous1.02359094
114MP0002064_seizures1.02126744
115MP0003935_abnormal_craniofacial_develop1.02119049
116MP0004197_abnormal_fetal_growth/weight/1.02079380
117MP0004084_abnormal_cardiac_muscle1.02057398
118MP0001324_abnormal_eye_pigmentation1.01799941
119MP0000343_altered_response_to1.01712795
120MP0005023_abnormal_wound_healing1.00761400
121MP0003705_abnormal_hypodermis_morpholog1.00634792
122MP0002184_abnormal_innervation1.00113201
123MP0005174_abnormal_tail_pigmentation0.98936762
124MP0001501_abnormal_sleep_pattern0.98651048
125MP0003121_genomic_imprinting0.98567296
126MP0002733_abnormal_thermal_nociception0.95604375
127MP0005408_hypopigmentation0.94972170
128MP0003635_abnormal_synaptic_transmissio0.94623812
129MP0002067_abnormal_sensory_capabilities0.94505190
130MP0003566_abnormal_cell_adhesion0.94343168
131MP0008058_abnormal_DNA_repair0.93581708
132MP0005084_abnormal_gallbladder_morpholo0.90624821
133MP0002734_abnormal_mechanical_nocicepti0.90078756
134MP0005410_abnormal_fertilization0.89307386
135MP0002063_abnormal_learning/memory/cond0.88740161
136MP0001963_abnormal_hearing_physiology0.88142066
137MP0001293_anophthalmia0.86606181
138MP0001188_hyperpigmentation0.86292003
139MP0003938_abnormal_ear_development0.85780485
140MP0002210_abnormal_sex_determination0.85543066
141MP0002095_abnormal_skin_pigmentation0.84632093
142MP0005083_abnormal_biliary_tract0.83665343
143MP0002693_abnormal_pancreas_physiology0.82562451
144MP0003091_abnormal_cell_migration0.82062890
145MP0004484_altered_response_of0.82009035
146MP0002098_abnormal_vibrissa_morphology0.80695618
147MP0002932_abnormal_joint_morphology0.80350206
148MP0005164_abnormal_response_to0.77861632
149MP0000462_abnormal_digestive_system0.75535448
150MP0010030_abnormal_orbit_morphology0.75225119
151MP0000566_synostosis0.72081465
152MP0001958_emphysema0.63991877
153MP0002735_abnormal_chemical_nociception0.62410034
154MP0003942_abnormal_urinary_system0.62337196
155MP0005379_endocrine/exocrine_gland_phen0.62022037
156MP0003385_abnormal_body_wall0.61957673
157MP0005646_abnormal_pituitary_gland0.61063196
158MP0000428_abnormal_craniofacial_morphol0.60558876
159MP0001943_abnormal_respiration0.58059243
160MP0001286_abnormal_eye_development0.56598061
161MP0005076_abnormal_cell_differentiation0.56268793
162MP0004036_abnormal_muscle_relaxation0.51618410
163MP0008775_abnormal_heart_ventricle0.50109641
164MP0002139_abnormal_hepatobiliary_system0.48486460
165MP0003119_abnormal_digestive_system0.46245654
166MP0005248_abnormal_Harderian_gland0.45314889
167MP0005367_renal/urinary_system_phenotyp0.44955499
168MP0000516_abnormal_urinary_system0.44955499
169MP0001177_atelectasis0.42904269
170MP0003941_abnormal_skin_development0.42766443
171MP0000026_abnormal_inner_ear0.41929234
172MP0003950_abnormal_plasma_membrane0.40288496
173MP0000465_gastrointestinal_hemorrhage0.38009111
174MP0005166_decreased_susceptibility_to0.37344220
175MP0002234_abnormal_pharynx_morphology0.34097849
176MP0001243_abnormal_dermal_layer0.33609114
177MP0009053_abnormal_anal_canal0.33328123
178MP0000537_abnormal_urethra_morphology0.29650003
179MP0003806_abnormal_nucleotide_metabolis0.28088871
180MP0005623_abnormal_meninges_morphology0.26748451
181MP0002081_perinatal_lethality0.25213255
182MP0001340_abnormal_eyelid_morphology0.25148242
183MP0005595_abnormal_vascular_smooth0.24927533
184MP0000534_abnormal_ureter_morphology0.24862390

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.82474732
2Irregular epiphyses (HP:0010582)9.46743914
3Vitreoretinal degeneration (HP:0000655)7.82581126
4Small epiphyses (HP:0010585)6.76288468
5Hypoplastic ischia (HP:0003175)6.66809400
6Abnormal tarsal ossification (HP:0008369)6.28598675
7Cupped ribs (HP:0000887)6.15789650
8Flat capital femoral epiphysis (HP:0003370)5.94186574
9Abnormality of the ischium (HP:0003174)5.90647304
10Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.69785169
11Delayed epiphyseal ossification (HP:0002663)5.64323019
12Flat acetabular roof (HP:0003180)5.37556152
13Genu varum (HP:0002970)5.28620179
14Metaphyseal cupping (HP:0003021)4.88932160
15Abnormal foot bone ossification (HP:0010675)4.62264950
16Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.59972672
17Abnormality of femoral epiphyses (HP:0006499)4.59972672
18Neonatal short-limb short stature (HP:0008921)4.37967438
19Absent epiphyses (HP:0010577)4.33906236
20Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.33906236
21Flattened epiphyses (HP:0003071)4.31656712
22Mild short stature (HP:0003502)4.25720720
23Arthropathy (HP:0003040)4.25646258
24Pancreatic cysts (HP:0001737)4.23153129
25Abnormality of the vertebral endplates (HP:0005106)4.21574919
26Abnormality of the epiphysis of the femoral head (HP:0010574)4.19303106
27Hyperventilation (HP:0002883)4.05994315
28Short femoral neck (HP:0100864)4.04379308
29Molar tooth sign on MRI (HP:0002419)3.96265245
30Abnormality of midbrain morphology (HP:0002418)3.96265245
31Irregular vertebral endplates (HP:0003301)3.89677832
32Abnormality of the femoral head (HP:0003368)3.87822418
33Metaphyseal dysplasia (HP:0100255)3.87326092
34Osteoarthritis (HP:0002758)3.85812875
35Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.73608081
36Congenital stationary night blindness (HP:0007642)3.72833140
37Metaphyseal irregularity (HP:0003025)3.72023431
38Pancreatic fibrosis (HP:0100732)3.70338982
39True hermaphroditism (HP:0010459)3.69825337
40Nephronophthisis (HP:0000090)3.69005389
41Abnormality of the renal cortex (HP:0011035)3.58237403
42Concave nail (HP:0001598)3.56423500
43Pigmentary retinal degeneration (HP:0001146)3.51056526
44Abnormality of the pubic bones (HP:0003172)3.29870636
45Abnormality of carpal bone ossification (HP:0006257)3.29735655
46Protuberant abdomen (HP:0001538)3.28728011
47Abnormal vertebral ossification (HP:0100569)3.27438255
48Abnormality of the proximal phalanges of the hand (HP:0009834)3.25727764
49Abnormality of the renal medulla (HP:0100957)3.19632275
50Medial flaring of the eyebrow (HP:0010747)3.16831968
51Coxa vara (HP:0002812)3.13536479
52Barrel-shaped chest (HP:0001552)3.12008071
53Renal cortical cysts (HP:0000803)3.11536019
54Beaking of vertebral bodies (HP:0004568)3.06552401
55Abnormality of the phalanges of the 2nd finger (HP:0009541)3.05384478
56Platyspondyly (HP:0000926)3.01280187
57Waddling gait (HP:0002515)2.96508002
58Abnormal rod and cone electroretinograms (HP:0008323)2.93816357
59Limited elbow extension (HP:0001377)2.91902753
60Cervical subluxation (HP:0003308)2.91448695
61Vertebral clefting (HP:0008428)2.89759293
62Cystic liver disease (HP:0006706)2.89725225
63Aplasia/hypoplasia of the femur (HP:0005613)2.88613212
64Pendular nystagmus (HP:0012043)2.86740412
65Carpal bone hypoplasia (HP:0001498)2.86607174
66Ovoid vertebral bodies (HP:0003300)2.86523120
67Enlarged epiphyses (HP:0010580)2.85386402
68Abnormality of hair growth rate (HP:0011363)2.83569233
69Slow-growing hair (HP:0002217)2.83569233
70Thoracolumbar scoliosis (HP:0002944)2.82234583
71Tubular atrophy (HP:0000092)2.81907445
72Limited hip movement (HP:0008800)2.81569185
73Type II lissencephaly (HP:0007260)2.75990694
74Gait imbalance (HP:0002141)2.70552708
75Exostoses (HP:0100777)2.67253045
76Stillbirth (HP:0003826)2.65399628
77Abnormal hand bone ossification (HP:0010660)2.63869747
78Lumbar hyperlordosis (HP:0002938)2.60561411
79Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.57377024
80Hip contracture (HP:0003273)2.56138835
81Congenital primary aphakia (HP:0007707)2.55485536
82Spinal cord compression (HP:0002176)2.54975425
83Hypoplasia of the odontoid process (HP:0003311)2.53484310
84Abnormal ossification of hand bones (HP:0005921)2.53479664
85Brittle hair (HP:0002299)2.53353179
86Absent frontal sinuses (HP:0002688)2.53221954
87Abnormality of incisor morphology (HP:0011063)2.52117379
88Thin ribs (HP:0000883)2.50138158
89Attenuation of retinal blood vessels (HP:0007843)2.48508353
90Glossoptosis (HP:0000162)2.48087522
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43020544
92Abnormal biliary tract physiology (HP:0012439)2.42529469
93Bile duct proliferation (HP:0001408)2.42529469
94Mesomelia (HP:0003027)2.40936856
95Abolished electroretinogram (ERG) (HP:0000550)2.38308233
96Keratoconus (HP:0000563)2.38276589
97Increased corneal curvature (HP:0100692)2.38276589
98Abnormality of the lumbar spine (HP:0100712)2.35758235
99Chronic hepatic failure (HP:0100626)2.34751294
100Absent/shortened dynein arms (HP:0200106)2.34247719
101Dynein arm defect of respiratory motile cilia (HP:0012255)2.34247719
102Abnormality of the vitreous humor (HP:0004327)2.33714863
103Abnormality of macular pigmentation (HP:0008002)2.33124204
104Nephrogenic diabetes insipidus (HP:0009806)2.32509559
105Fibular hypoplasia (HP:0003038)2.31716732
106Hyperglycinuria (HP:0003108)2.31505796
107Hypoplastic pelvis (HP:0008839)2.30898400
108Long clavicles (HP:0000890)2.26395582
109Disproportionate short-trunk short stature (HP:0003521)2.21939305
110Hypoplastic ilia (HP:0000946)2.20890539
111Micromelia (HP:0002983)2.20127174
112Progressive cerebellar ataxia (HP:0002073)2.17894830
113Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.17632520
114Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.17181702
115Vertebral hypoplasia (HP:0008417)2.17181702
116Abnormality of the 2nd finger (HP:0004100)2.14838352
117Aplasia/Hypoplasia of the tongue (HP:0010295)2.14357294
118Relative macrocephaly (HP:0004482)2.14217524
119Aplasia/Hypoplasia of the tibia (HP:0005772)2.13333898
120Broad phalanx (HP:0006009)2.12201953
121Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.12117348
122Genital tract atresia (HP:0001827)2.11981670
123Hypotrichosis (HP:0001006)2.11011284
124Short middle phalanx of finger (HP:0005819)2.10613662
125Decreased central vision (HP:0007663)2.09722161
126Pachygyria (HP:0001302)2.09302629
127Abnormality of the odontoid process (HP:0003310)2.08572983
128Furrowed tongue (HP:0000221)2.08104328
129Vaginal atresia (HP:0000148)2.06364744
130Anencephaly (HP:0002323)2.05224661
131Large for gestational age (HP:0001520)2.04400887
132Congenital, generalized hypertrichosis (HP:0004540)2.03988594
133Supernumerary spleens (HP:0009799)2.03543885
134Abnormal drinking behavior (HP:0030082)2.03283053
135Polydipsia (HP:0001959)2.03283053
136Lissencephaly (HP:0001339)2.02322789
137Flared metaphyses (HP:0003015)2.00303006
138Mixed hearing impairment (HP:0000410)1.98711739
139Broad long bones (HP:0005622)1.96917926
140Abnormality of the acetabulum (HP:0003170)1.96874098
141Abnormality of the phalanges of the 5th finger (HP:0004213)1.96570625
142Breast carcinoma (HP:0003002)1.96045660
143Bony spicule pigmentary retinopathy (HP:0007737)1.95937311
144Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.95265991
145Poor coordination (HP:0002370)1.94191115
146Sclerocornea (HP:0000647)1.93948118
147Short tibia (HP:0005736)1.92997725
148Mitochondrial inheritance (HP:0001427)1.92993913
149Optic disc pallor (HP:0000543)1.92678413
150Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92617875
151Male pseudohermaphroditism (HP:0000037)1.90343032
152Rhizomelia (HP:0008905)1.89665782
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88755221
154Limb hypertonia (HP:0002509)1.88275061
155Increased CSF lactate (HP:0002490)1.88134165
156Acute necrotizing encephalopathy (HP:0006965)1.87922147
157Gaze-evoked nystagmus (HP:0000640)1.87671665
158Rib fusion (HP:0000902)1.87666017
159Broad thumb (HP:0011304)1.86731164
160Cerebellar dysplasia (HP:0007033)1.86007896
161Postaxial foot polydactyly (HP:0001830)1.85280816
162Radial bowing (HP:0002986)1.84934472
163Limb dystonia (HP:0002451)1.84766159
164Acute encephalopathy (HP:0006846)1.84361862
165Inability to walk (HP:0002540)1.83161431
166Short ribs (HP:0000773)1.83007235
167Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82401025
1683-Methylglutaconic aciduria (HP:0003535)1.82244393
169Abnormality of the frontal sinuses (HP:0002687)1.81405243
170Absent speech (HP:0001344)1.80711611
171Progressive inability to walk (HP:0002505)1.80471621
172Genu valgum (HP:0002857)1.79905246
173Aplasia/Hypoplasia of the spleen (HP:0010451)1.79380612
174Postaxial hand polydactyly (HP:0001162)1.78569701
175Abnormality of the middle phalanges of the toes (HP:0010183)1.78072504
176Agitation (HP:0000713)1.77978899
177Aplasia/Hypoplasia of the uvula (HP:0010293)1.76828568
178Hypoplastic scapulae (HP:0000882)1.76745142
179Aplasia/Hypoplasia of the scapulae (HP:0006713)1.76745142
180Abnormality of glycine metabolism (HP:0010895)1.75792996
181Abnormality of serine family amino acid metabolism (HP:0010894)1.75792996
182Congenital hepatic fibrosis (HP:0002612)1.75102159
183Optic nerve hypoplasia (HP:0000609)1.74909012
184Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73778299
185Retinitis pigmentosa (HP:0000510)1.72196845
186Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72089802
187Abnormality of alanine metabolism (HP:0010916)1.72089802
188Hyperalaninemia (HP:0003348)1.72089802
189Hepatic necrosis (HP:0002605)1.71998259
190Abnormality of the labia minora (HP:0012880)1.71716607
191Severe muscular hypotonia (HP:0006829)1.67784226
192Abnormality of the pons (HP:0007361)1.66617597
193Progressive macrocephaly (HP:0004481)1.66147582
194Asplenia (HP:0001746)1.66136597
195Ketosis (HP:0001946)1.66094137
196Broad-based gait (HP:0002136)1.65915832
197Tubulointerstitial nephritis (HP:0001970)1.64728314
198Preaxial hand polydactyly (HP:0001177)1.62804646
199Aganglionic megacolon (HP:0002251)1.62668141
200Hypoplasia of the pons (HP:0012110)1.61704563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.77865585
2MAP3K36.90037334
3STK38L4.84667321
4STK244.58365563
5FRK4.47820672
6NME14.14104666
7CASK4.11857737
8PRKG24.00847355
9ADRBK23.11579065
10GRK12.52173550
11MAP4K22.43428054
12MST42.26613376
13WNK32.25587660
14OXSR12.15334934
15ERBB32.13584734
16MAPK132.11356178
17ZAK2.04888986
18PRKD31.94412103
19TAOK31.84702773
20MAP3K41.79148270
21PLK21.77796228
22TLK11.72969071
23TAF11.68242160
24TAOK11.66035604
25NTRK31.63149114
26MARK11.56983060
27MAPKAPK31.54967812
28TRIM281.51432692
29NUAK11.51073445
30MUSK1.49843940
31AKT31.47491983
32DYRK1A1.45872298
33MKNK21.42668132
34SIK11.42399656
35STK31.38196599
36PIM21.38075136
37LATS11.34080764
38TXK1.33806502
39PBK1.27105017
40EIF2AK31.25321758
41MAP2K71.25198085
42DYRK21.23975092
43TRPM71.21050221
44NME21.15152180
45BCKDK1.14784790
46NEK61.13839147
47MAPK121.12752117
48MAPK71.02987992
49INSRR0.99598269
50DAPK20.99453619
51TNK20.98283675
52ACVR1B0.91632276
53ROCK10.91077101
54MET0.87549664
55PIK3CA0.87024111
56CAMKK20.86274508
57VRK20.85907712
58CSNK1G20.85618025
59VRK10.85484694
60EIF2AK10.83637674
61CAMK1D0.81329459
62PHKG20.81133141
63PHKG10.81133141
64DYRK30.80344460
65FER0.79662634
66PDK20.78681530
67EPHB20.78648047
68WNK40.78065090
69MKNK10.77154931
70MAPK40.75204446
71CSNK1G30.74962063
72SIK20.72958620
73TNIK0.72687150
74GSK3A0.72540456
75STK160.72359678
76CHUK0.71026428
77TAOK20.68050024
78EPHA20.65274412
79FGFR30.64506439
80BCR0.61905464
81TIE10.60366928
82MAP2K30.59999552
83CDK30.59925321
84MAPKAPK50.58967537
85ITK0.58574334
86PNCK0.58570936
87PRKCZ0.57938463
88FGFR20.51437701
89CSNK1A10.51338944
90MINK10.50681182
91PLK30.48688102
92FGFR10.47780730
93EIF2AK20.46498458
94MAP2K10.46309025
95CAMK1G0.45965391
96STK390.45552729
97RPS6KB20.44972728
98MAP3K110.44613403
99CAMK10.44610159
100NLK0.43221255
101TRIB30.43171127
102TGFBR10.42068864
103BRSK20.41729191
104EPHA40.41224725
105NTRK20.41048199
106PRKG10.40941011
107CSNK1D0.40816363
108CSNK1E0.39441069
109BMPR1B0.39007950
110CAMK2A0.38650333
111KSR10.37937071
112MAPK150.36937534
113CSNK1A1L0.35631969
114PIM10.34442988
115PTK2B0.34374187
116CSF1R0.32734899
117PRKACG0.32485643
118RPS6KB10.32261212
119MAP2K60.32072587
120IRAK40.31486177
121DYRK1B0.30718525
122PRKCD0.30044080
123PRKAA10.29070958
124PRKCH0.26311887
125ADRBK10.26236796
126SGK10.23875895
127IGF1R0.23714525
128CAMKK10.22873002
129MST1R0.22407610
130MAPK30.21538411
131LIMK10.20879612
132MAPK100.20536672
133MAPK10.18250921
134MAP3K50.18106703
135MELK0.17964071
136STK100.17827194
137PRKCI0.17110755
138ABL10.15899537
139PRKACA0.15532665
140PRKCQ0.13399616
141BMPR20.13265914
142CSNK1G10.13172839
143PRKCE0.13035025
144IKBKB0.12739352
145INSR0.11948890
146PRKCA0.10974076
147MARK30.09884934
148GRK50.09260254
149PDK10.09209438
150EGFR0.09178197
151TEC0.08440278
152EPHB10.08005750
153PRKCG0.07027391
154PAK30.06837304
155ROCK20.06792103
156CAMK2D0.06509060
157SIK30.05339685
158PINK10.05181069
159PDGFRB0.05075903
160PTK20.04756052
161LATS20.04557706
162MAPK140.03950116

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005328.17425198
2ECM-receptor interaction_Homo sapiens_hsa045126.56624681
3Protein digestion and absorption_Homo sapiens_hsa049746.00857298
4Phototransduction_Homo sapiens_hsa047442.89299831
5Sphingolipid metabolism_Homo sapiens_hsa006002.75211737
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.68609351
7Sulfur metabolism_Homo sapiens_hsa009202.65565025
8Oxidative phosphorylation_Homo sapiens_hsa001902.62292067
9Steroid biosynthesis_Homo sapiens_hsa001002.55121703
10Nitrogen metabolism_Homo sapiens_hsa009102.44579514
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.39042982
12Linoleic acid metabolism_Homo sapiens_hsa005912.36566909
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.35116845
14Focal adhesion_Homo sapiens_hsa045102.31440421
15Protein export_Homo sapiens_hsa030602.00689175
16Butanoate metabolism_Homo sapiens_hsa006501.98948436
17Olfactory transduction_Homo sapiens_hsa047401.95324652
18Nicotine addiction_Homo sapiens_hsa050331.93708024
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.91040132
20Parkinsons disease_Homo sapiens_hsa050121.89134297
21Malaria_Homo sapiens_hsa051441.83364328
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.79949452
23Caffeine metabolism_Homo sapiens_hsa002321.78768217
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77964781
25TGF-beta signaling pathway_Homo sapiens_hsa043501.73511286
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73029439
27Starch and sucrose metabolism_Homo sapiens_hsa005001.70452876
28Tryptophan metabolism_Homo sapiens_hsa003801.68268680
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67357728
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.65452226
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65071262
32RNA polymerase_Homo sapiens_hsa030201.60963665
33Peroxisome_Homo sapiens_hsa041461.59429571
34Propanoate metabolism_Homo sapiens_hsa006401.58317854
35Basal transcription factors_Homo sapiens_hsa030221.56341924
36Fanconi anemia pathway_Homo sapiens_hsa034601.55807591
37Homologous recombination_Homo sapiens_hsa034401.55140548
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54355012
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.53805620
40Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47018623
41Ether lipid metabolism_Homo sapiens_hsa005651.45701690
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45548630
43Regulation of autophagy_Homo sapiens_hsa041401.44564569
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38430968
45ABC transporters_Homo sapiens_hsa020101.38183899
46Other glycan degradation_Homo sapiens_hsa005111.37999179
47Cardiac muscle contraction_Homo sapiens_hsa042601.35847570
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.34732789
49Taste transduction_Homo sapiens_hsa047421.31748318
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30312729
51Alzheimers disease_Homo sapiens_hsa050101.29242816
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26847148
53RNA degradation_Homo sapiens_hsa030181.23047139
54Huntingtons disease_Homo sapiens_hsa050161.20805093
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18336611
56Morphine addiction_Homo sapiens_hsa050321.13598781
57Proteasome_Homo sapiens_hsa030501.13378186
58Ovarian steroidogenesis_Homo sapiens_hsa049131.12862383
59Arginine and proline metabolism_Homo sapiens_hsa003301.10216706
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08410312
61Selenocompound metabolism_Homo sapiens_hsa004501.07589949
62Hedgehog signaling pathway_Homo sapiens_hsa043401.06215973
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04916597
64Primary bile acid biosynthesis_Homo sapiens_hsa001201.03012497
65Chemical carcinogenesis_Homo sapiens_hsa052041.00818096
66Hippo signaling pathway_Homo sapiens_hsa043900.96937622
67Basal cell carcinoma_Homo sapiens_hsa052170.95998460
68Proteoglycans in cancer_Homo sapiens_hsa052050.95696159
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93559773
70Fatty acid elongation_Homo sapiens_hsa000620.92230069
71Fatty acid metabolism_Homo sapiens_hsa012120.90356290
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88820808
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87193191
74GABAergic synapse_Homo sapiens_hsa047270.84400351
75Retinol metabolism_Homo sapiens_hsa008300.84118635
76Purine metabolism_Homo sapiens_hsa002300.83062642
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82155564
78Glutamatergic synapse_Homo sapiens_hsa047240.82147062
79Collecting duct acid secretion_Homo sapiens_hsa049660.81712207
80Folate biosynthesis_Homo sapiens_hsa007900.78779877
81Serotonergic synapse_Homo sapiens_hsa047260.76035757
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73018292
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71851701
84Ribosome_Homo sapiens_hsa030100.70390764
85Phagosome_Homo sapiens_hsa041450.69514898
86Dopaminergic synapse_Homo sapiens_hsa047280.69093969
87Long-term depression_Homo sapiens_hsa047300.68971336
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68765198
89Fatty acid biosynthesis_Homo sapiens_hsa000610.67474814
90Vibrio cholerae infection_Homo sapiens_hsa051100.64443185
91Pyrimidine metabolism_Homo sapiens_hsa002400.63754565
92Lysine degradation_Homo sapiens_hsa003100.63327379
93Fat digestion and absorption_Homo sapiens_hsa049750.62432542
94Galactose metabolism_Homo sapiens_hsa000520.61130348
95Thyroid hormone synthesis_Homo sapiens_hsa049180.60553244
96Salivary secretion_Homo sapiens_hsa049700.58325786
97N-Glycan biosynthesis_Homo sapiens_hsa005100.58268721
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55704568
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54837466
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54232723
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52150010
102Arachidonic acid metabolism_Homo sapiens_hsa005900.51854967
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50347477
104Dilated cardiomyopathy_Homo sapiens_hsa054140.49455860
105Circadian entrainment_Homo sapiens_hsa047130.46405957
106beta-Alanine metabolism_Homo sapiens_hsa004100.45842432
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43530079
108Melanogenesis_Homo sapiens_hsa049160.43351970
109Wnt signaling pathway_Homo sapiens_hsa043100.42156817
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42123871
111Histidine metabolism_Homo sapiens_hsa003400.41684297
112HIF-1 signaling pathway_Homo sapiens_hsa040660.40907262
113Fatty acid degradation_Homo sapiens_hsa000710.38981816
114Gap junction_Homo sapiens_hsa045400.38786897
115Calcium signaling pathway_Homo sapiens_hsa040200.35452314
116One carbon pool by folate_Homo sapiens_hsa006700.35128530
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34832612
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34102333
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34063940
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33792148
121Pancreatic secretion_Homo sapiens_hsa049720.31632859
122Circadian rhythm_Homo sapiens_hsa047100.31522642
123Hematopoietic cell lineage_Homo sapiens_hsa046400.31298076
124Oxytocin signaling pathway_Homo sapiens_hsa049210.31190658
125Dorso-ventral axis formation_Homo sapiens_hsa043200.31032442
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.29906037
127Non-homologous end-joining_Homo sapiens_hsa034500.28565416
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27961076
129Nucleotide excision repair_Homo sapiens_hsa034200.27399190
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26483989
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25813823
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25200858
133Cocaine addiction_Homo sapiens_hsa050300.24137724
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24096183
135Amphetamine addiction_Homo sapiens_hsa050310.23778312
136Bladder cancer_Homo sapiens_hsa052190.22322818
137Complement and coagulation cascades_Homo sapiens_hsa046100.21342689
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19712104
139Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19232036
140cAMP signaling pathway_Homo sapiens_hsa040240.16678548
141Cholinergic synapse_Homo sapiens_hsa047250.16678476
142Vitamin digestion and absorption_Homo sapiens_hsa049770.16101450
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15994213
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.15691954
145Insulin secretion_Homo sapiens_hsa049110.14714547
146Prostate cancer_Homo sapiens_hsa052150.14182467
147Insulin resistance_Homo sapiens_hsa049310.13963286
148Platelet activation_Homo sapiens_hsa046110.13695175
149Hepatitis B_Homo sapiens_hsa051610.13677809
150Thyroid cancer_Homo sapiens_hsa052160.13656276
151Mineral absorption_Homo sapiens_hsa049780.13644485
152HTLV-I infection_Homo sapiens_hsa051660.12229772
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11632410
154Legionellosis_Homo sapiens_hsa051340.10112741
155Metabolic pathways_Homo sapiens_hsa011000.09707098
156Glucagon signaling pathway_Homo sapiens_hsa049220.09155149
157Neurotrophin signaling pathway_Homo sapiens_hsa047220.08953534
158Adherens junction_Homo sapiens_hsa045200.08793828
159MicroRNAs in cancer_Homo sapiens_hsa052060.08463165
160Bile secretion_Homo sapiens_hsa049760.08446770
161Renal cell carcinoma_Homo sapiens_hsa052110.08101611
162Axon guidance_Homo sapiens_hsa043600.06097559
163Sphingolipid signaling pathway_Homo sapiens_hsa040710.05605935
164Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.05299035
165Central carbon metabolism in cancer_Homo sapiens_hsa052300.04433734

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