CLEC2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.85721267
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.44073173
3regulation of B cell receptor signaling pathway (GO:0050855)5.21422243
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.02220145
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.93470525
6negative regulation of cell killing (GO:0031342)4.93470525
7regulation of gamma-delta T cell activation (GO:0046643)4.47592300
8regulation of gamma-delta T cell differentiation (GO:0045586)4.46263899
9immunoglobulin mediated immune response (GO:0016064)4.31492444
10positive thymic T cell selection (GO:0045059)4.19472724
11antigen processing and presentation of endogenous antigen (GO:0019883)4.09936428
12neutrophil activation involved in immune response (GO:0002283)4.09026544
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06109257
14negative T cell selection (GO:0043383)4.03381734
15positive T cell selection (GO:0043368)3.93246818
16positive regulation of B cell differentiation (GO:0045579)3.89042144
17negative thymic T cell selection (GO:0045060)3.86966432
18negative regulation of interleukin-12 production (GO:0032695)3.85446473
19T cell migration (GO:0072678)3.75074823
20leukocyte aggregation (GO:0070486)3.69972482
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.69922406
22cellular response to interleukin-15 (GO:0071350)3.69001166
23response to interleukin-15 (GO:0070672)3.65418760
24neutrophil activation (GO:0042119)3.61146819
25regulation of regulatory T cell differentiation (GO:0045589)3.59568461
26cellular extravasation (GO:0045123)3.55512846
27interferon-gamma-mediated signaling pathway (GO:0060333)3.54176324
28response to peptidoglycan (GO:0032494)3.53210329
29regulation of T cell tolerance induction (GO:0002664)3.51413377
30regulation of alpha-beta T cell proliferation (GO:0046640)3.50034758
31B cell mediated immunity (GO:0019724)3.49996166
32regulation of tolerance induction (GO:0002643)3.48240440
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.47990663
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.47990663
35positive regulation by organism of defense response of other organism involved in symbiotic interact3.47990663
36modulation by symbiont of host immune response (GO:0052553)3.47990663
37positive regulation by symbiont of host defense response (GO:0052509)3.47990663
38modulation by symbiont of host defense response (GO:0052031)3.47990663
39regulation of B cell differentiation (GO:0045577)3.47019539
40mast cell activation (GO:0045576)3.45612577
41detection of molecule of bacterial origin (GO:0032490)3.44014115
42granulocyte activation (GO:0036230)3.42500938
43detection of other organism (GO:0098543)3.40702634
44B cell receptor signaling pathway (GO:0050853)3.35527490
45antigen processing and presentation via MHC class Ib (GO:0002475)3.35250129
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.34950935
47negative regulation of T cell mediated immunity (GO:0002710)3.34580599
48cytidine metabolic process (GO:0046087)3.31554471
49cytidine catabolic process (GO:0006216)3.31554471
50cytidine deamination (GO:0009972)3.31554471
51type I interferon signaling pathway (GO:0060337)3.31274261
52cellular response to type I interferon (GO:0071357)3.31274261
53T cell selection (GO:0045058)3.29518857
54response to type I interferon (GO:0034340)3.29393777
55regulation of T cell mediated cytotoxicity (GO:0001914)3.26098683
56regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.24555303
57detection of external biotic stimulus (GO:0098581)3.24286127
58positive regulation of tolerance induction (GO:0002645)3.24054476
59positive regulation of alpha-beta T cell proliferation (GO:0046641)3.22732122
60macrophage activation involved in immune response (GO:0002281)3.21788777
61detection of bacterium (GO:0016045)3.21427153
62negative regulation of lymphocyte mediated immunity (GO:0002707)3.19694401
63myeloid cell activation involved in immune response (GO:0002275)3.19327600
64microglial cell activation (GO:0001774)3.19057696
65interferon-gamma production (GO:0032609)3.18575122
66Arp2/3 complex-mediated actin nucleation (GO:0034314)3.16314812
67positive regulation of T cell mediated cytotoxicity (GO:0001916)3.15786036
68regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.13392680
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.09048949
70thymic T cell selection (GO:0045061)3.08981206
71antigen receptor-mediated signaling pathway (GO:0050851)3.06380113
72regulation of natural killer cell mediated immunity (GO:0002715)3.05995227
73regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.05995227
74negative regulation of leukocyte mediated immunity (GO:0002704)3.00523194
75pyrimidine ribonucleoside catabolic process (GO:0046133)2.99230882
76regulation of leukocyte mediated cytotoxicity (GO:0001910)2.98064624
77T cell receptor signaling pathway (GO:0050852)2.97617497
78regulation of antigen processing and presentation (GO:0002577)2.97470895
79leukocyte degranulation (GO:0043299)2.97209672
80activated T cell proliferation (GO:0050798)2.96747751
81response to interferon-beta (GO:0035456)2.96130171
82detection of biotic stimulus (GO:0009595)2.95407477
83positive regulation of granulocyte differentiation (GO:0030854)2.94320801
84lymphocyte chemotaxis (GO:0048247)2.93621522
85defense response to protozoan (GO:0042832)2.93402551
86DNA deamination (GO:0045006)2.90467866
87tolerance induction (GO:0002507)2.90004782
88positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.89935630
89positive regulation of antigen processing and presentation (GO:0002579)2.89272726
90mature B cell differentiation involved in immune response (GO:0002313)2.88348325
91lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87539774
92respiratory burst (GO:0045730)2.86766950
93positive regulation of mast cell activation (GO:0033005)2.86682642
94regulation of mast cell activation (GO:0033003)2.85939785
95positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.85634630
96T cell costimulation (GO:0031295)2.85448538
97positive regulation of defense response to virus by host (GO:0002230)2.84453143
98negative regulation of viral genome replication (GO:0045071)2.84351047
99negative regulation of innate immune response (GO:0045824)2.83777383
100regulation of mast cell degranulation (GO:0043304)2.82256271

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.67575031
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.55659099
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.90686572
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.86162335
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.32600439
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.24469540
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.48063476
8RUNX_20019798_ChIP-Seq_JUKART_Human3.39655513
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19644563
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.09967374
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.98283468
12MYB_26560356_Chip-Seq_TH2_Human2.91721927
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80014350
14SCL_19346495_ChIP-Seq_HPC-7_Human2.52570047
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.51980270
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42691481
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31800141
18FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.29769641
19SPI1_23547873_ChIP-Seq_NB4_Human2.29555299
20MYB_26560356_Chip-Seq_TH1_Human2.28221416
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27933975
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.26283813
23GATA3_27048872_Chip-Seq_THYMUS_Human2.08882620
24VDR_24787735_ChIP-Seq_THP-1_Human2.00357208
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97574368
26SPI1_23127762_ChIP-Seq_K562_Human1.95834901
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.95484802
28MAF_26560356_Chip-Seq_TH1_Human1.94874968
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94646194
30GATA3_26560356_Chip-Seq_TH2_Human1.93134839
31VDR_24763502_ChIP-Seq_THP-1_Human1.92587289
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87195535
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81665868
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78475294
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77423756
36UTX_26944678_Chip-Seq_JUKART_Human1.76858291
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69631073
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.62669796
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59046441
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56349444
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49443469
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48877964
43VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.35137454
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34937181
45MAF_26560356_Chip-Seq_TH2_Human1.34128509
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32503173
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31037050
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27864123
49VDR_21846776_ChIP-Seq_THP-1_Human1.21954444
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19692379
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.19298405
52GATA1_22025678_ChIP-Seq_K562_Human1.17923944
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17432258
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14746099
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14473208
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11614131
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10833756
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08245744
59* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06134904
60PU_27001747_Chip-Seq_BMDM_Mouse1.05789920
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04930287
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.03906474
63SMRT_27268052_Chip-Seq_Bcells_Human1.00622763
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98953980
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96029358
66STAT1_20625510_ChIP-Seq_HELA_Human0.92989595
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91709560
68BCL6_27268052_Chip-Seq_Bcells_Human0.91567938
69GATA1_19941826_ChIP-Seq_K562_Human0.89067194
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88870344
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84936529
72* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84110001
73TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.83629900
74EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83270219
75* GATA3_26560356_Chip-Seq_TH1_Human0.82947489
76TCF7_22412390_ChIP-Seq_EML_Mouse0.82780053
77STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81651145
78NOTCH1_21737748_ChIP-Seq_TLL_Human0.81270942
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78208278
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77597277
81MYC_22102868_ChIP-Seq_BL_Human0.77441165
82SPI1_20517297_ChIP-Seq_HL60_Human0.76470724
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75755133
84RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75163697
85GATA2_19941826_ChIP-Seq_K562_Human0.74886724
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.74866377
87P300_27268052_Chip-Seq_Bcells_Human0.73530207
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72927527
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.70702084
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70659733
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69189600
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68821632
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68216204
94BCOR_27268052_Chip-Seq_Bcells_Human0.68197940
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.68002664
96FLI1_27457419_Chip-Seq_LIVER_Mouse0.67486645
97TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.67056934
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.66496255
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.65962953
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65602808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.30625132
2MP0001835_abnormal_antigen_presentation4.23121703
3MP0003724_increased_susceptibility_to4.16790081
4MP0003436_decreased_susceptibility_to3.52778968
5MP0009785_altered_susceptibility_to3.40200394
6MP0001800_abnormal_humoral_immune3.13838848
7MP0005000_abnormal_immune_tolerance3.10612217
8MP0002148_abnormal_hypersensitivity_rea2.96506680
9MP0005025_abnormal_response_to2.84824730
10MP0000685_abnormal_immune_system2.82481208
11MP0002723_abnormal_immune_serum2.78148067
12MP0001790_abnormal_immune_system2.77493781
13MP0005387_immune_system_phenotype2.77493781
14MP0002419_abnormal_innate_immunity2.76464591
15MP0006082_CNS_inflammation2.73729997
16MP0003763_abnormal_thymus_physiology2.68545670
17MP0002452_abnormal_antigen_presenting2.67138773
18MP0002420_abnormal_adaptive_immunity2.59544772
19MP0001819_abnormal_immune_cell2.56765985
20MP0003303_peritoneal_inflammation2.44808579
21MP0002405_respiratory_system_inflammati2.08910535
22MP0005464_abnormal_platelet_physiology2.01219027
23MP0002398_abnormal_bone_marrow1.99301394
24MP0000716_abnormal_immune_system1.98278956
25MP0009764_decreased_sensitivity_to1.97344113
26MP0002166_altered_tumor_susceptibility1.94797371
27MP0010155_abnormal_intestine_physiology1.93759612
28MP0001533_abnormal_skeleton_physiology1.91482902
29MP0009333_abnormal_splenocyte_physiolog1.86650069
30MP0001845_abnormal_inflammatory_respons1.82823590
31MP0004947_skin_inflammation1.74785579
32MP0000689_abnormal_spleen_morphology1.70475744
33MP0003866_abnormal_defecation1.69301431
34MP0000465_gastrointestinal_hemorrhage1.66835451
35MP0002722_abnormal_immune_system1.63799299
36MP0002429_abnormal_blood_cell1.53497139
37MP0001853_heart_inflammation1.51366392
38MP0008469_abnormal_protein_level1.49556876
39MP0000703_abnormal_thymus_morphology1.46195114
40MP0003300_gastrointestinal_ulcer1.44872636
41MP0001873_stomach_inflammation1.39327996
42MP0003191_abnormal_cellular_cholesterol1.39327008
43MP0002006_tumorigenesis1.38546633
44MP0009278_abnormal_bone_marrow1.38135935
45MP0000569_abnormal_digit_pigmentation1.36633618
46MP0003828_pulmonary_edema1.29957837
47MP0003172_abnormal_lysosome_physiology1.28367297
48MP0002933_joint_inflammation1.27925195
49MP0005310_abnormal_salivary_gland1.27452771
50MP0003448_altered_tumor_morphology1.23834702
51MP0002998_abnormal_bone_remodeling1.22572779
52MP0001545_abnormal_hematopoietic_system1.22406048
53MP0005397_hematopoietic_system_phenotyp1.22406048
54MP0002138_abnormal_hepatobiliary_system1.19920005
55MP0003806_abnormal_nucleotide_metabolis1.16520728
56MP0003075_altered_response_to1.12339407
57MP0004883_abnormal_blood_vessel1.06280754
58MP0002277_abnormal_respiratory_mucosa1.05420365
59MP0005166_decreased_susceptibility_to1.04295557
60MP0000858_altered_metastatic_potential1.03444409
61MP0003183_abnormal_peptide_metabolism1.01270281
62MP0001851_eye_inflammation1.01013064
63MP0008260_abnormal_autophagy0.99656108
64MP0005451_abnormal_body_composition0.99323667
65MP0003045_fibrosis0.99214830
66MP0005058_abnormal_lysosome_morphology0.98406082
67MP0005075_abnormal_melanosome_morpholog0.96908613
68MP0009763_increased_sensitivity_to0.94917650
69MP0000343_altered_response_to0.94218021
70MP0004381_abnormal_hair_follicle0.94179530
71MP0000604_amyloidosis0.92783633
72MP0002132_abnormal_respiratory_system0.91482759
73MP0005164_abnormal_response_to0.90542982
74MP0002396_abnormal_hematopoietic_system0.89341383
75MP0002009_preneoplasia0.86846173
76MP0004510_myositis0.86117291
77MP0004808_abnormal_hematopoietic_stem0.83987321
78MP0005390_skeleton_phenotype0.82113812
79MP0000249_abnormal_blood_vessel0.81119519
80MP0009765_abnormal_xenobiotic_induced0.77536006
81MP0003656_abnormal_erythrocyte_physiolo0.75428967
82MP0008004_abnormal_stomach_pH0.74794311
83MP0005167_abnormal_blood-brain_barrier0.73508997
84MP0001663_abnormal_digestive_system0.72711351
85MP0005410_abnormal_fertilization0.67917344
86MP0003690_abnormal_glial_cell0.67556614
87MP0001501_abnormal_sleep_pattern0.67271485
88MP0002019_abnormal_tumor_incidence0.61561728
89MP0000015_abnormal_ear_pigmentation0.60715282
90MP0005174_abnormal_tail_pigmentation0.59029774
91MP0003795_abnormal_bone_structure0.58757834
92MP0002332_abnormal_exercise_endurance0.56628322
93MP0006054_spinal_hemorrhage0.54317276
94MP0009840_abnormal_foam_cell0.53738116
95MP0002136_abnormal_kidney_physiology0.53396819
96MP0002693_abnormal_pancreas_physiology0.52580047
97MP0004484_altered_response_of0.51130515
98MP0001986_abnormal_taste_sensitivity0.50953667
99MP0008873_increased_physiological_sensi0.48901164
100MP0005319_abnormal_enzyme/_coenzyme0.47837018

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.52136672
2Stomatitis (HP:0010280)5.27868194
3T lymphocytopenia (HP:0005403)5.06108724
4Abnormality of T cell number (HP:0011839)4.93358594
5Myositis (HP:0100614)4.76632164
6Recurrent bacterial skin infections (HP:0005406)4.64511512
7Recurrent abscess formation (HP:0002722)4.53686053
8Eczematoid dermatitis (HP:0000976)4.40215400
9Optic neuritis (HP:0100653)4.36575345
10Retrobulbar optic neuritis (HP:0100654)4.36575345
11Orchitis (HP:0100796)4.25642479
12Recurrent fungal infections (HP:0002841)4.12403996
13Abnormality of macrophages (HP:0004311)4.05373406
14Abnormality of T cells (HP:0002843)3.96146741
15Autoimmune hemolytic anemia (HP:0001890)3.95907723
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.82207523
17Chronic mucocutaneous candidiasis (HP:0002728)3.82191166
18Recurrent cutaneous fungal infections (HP:0011370)3.82191166
19Autoimmune thrombocytopenia (HP:0001973)3.73113257
20Meningitis (HP:0001287)3.70052268
21Gastrointestinal infarctions (HP:0005244)3.58291645
22Chronic obstructive pulmonary disease (HP:0006510)3.57991147
23Obstructive lung disease (HP:0006536)3.57991147
24Recurrent skin infections (HP:0001581)3.55460854
25Encephalitis (HP:0002383)3.51400638
26IgG deficiency (HP:0004315)3.50159645
27Mediastinal lymphadenopathy (HP:0100721)3.43911869
28Increased IgM level (HP:0003496)3.42563438
29Vasculitis (HP:0002633)3.40900371
30Pulmonary infiltrates (HP:0002113)3.33658931
31Hemoptysis (HP:0002105)3.29061136
32Leukocytosis (HP:0001974)3.28225326
33Keratoconjunctivitis sicca (HP:0001097)3.26715610
34Recurrent gram-negative bacterial infections (HP:0005420)3.21019847
35Recurrent viral infections (HP:0004429)3.19046131
36Keratoconjunctivitis (HP:0001096)3.11809463
37Severe combined immunodeficiency (HP:0004430)3.07473514
38Abnormality of T cell physiology (HP:0011840)3.06161820
39Pustule (HP:0200039)2.95861761
40Abnormality of the prostate (HP:0008775)2.94594255
41Chest pain (HP:0100749)2.92051511
42Recurrent bronchitis (HP:0002837)2.91861743
43Panhypogammaglobulinemia (HP:0003139)2.89894199
44Eosinophilia (HP:0001880)2.88816889
45Abnormality of B cell number (HP:0010975)2.86028708
46Spontaneous hematomas (HP:0007420)2.86010939
47Abnormality of eosinophils (HP:0001879)2.84754641
48Abnormality of liposaccharide metabolism (HP:0010968)2.81146946
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.81146946
50Abnormality of glycolipid metabolism (HP:0010969)2.81146946
51Granulocytopenia (HP:0001913)2.80821637
52Chronic diarrhea (HP:0002028)2.80216489
53Increased IgE level (HP:0003212)2.79275498
54Agammaglobulinemia (HP:0004432)2.69142193
55Arterial thrombosis (HP:0004420)2.67416179
56Urticaria (HP:0001025)2.66038623
57Gangrene (HP:0100758)2.63258154
58Epistaxis (HP:0000421)2.62034863
59Thyroiditis (HP:0100646)2.61727211
60Prolonged bleeding time (HP:0003010)2.59050599
61Pulmonary embolism (HP:0002204)2.57176476
62Gingivitis (HP:0000230)2.57039630
63Gingival bleeding (HP:0000225)2.55303313
64Hypergammaglobulinemia (HP:0010702)2.53483055
65Inflammation of the large intestine (HP:0002037)2.52946561
66Combined immunodeficiency (HP:0005387)2.48445071
67Abnormality of the pleura (HP:0002103)2.41943563
68Increased cerebral lipofuscin (HP:0011813)2.34731733
69B lymphocytopenia (HP:0010976)2.33180332
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.31597146
71Petechiae (HP:0000967)2.31161191
72Gastrointestinal inflammation (HP:0004386)2.30618321
73Stomach cancer (HP:0012126)2.28015985
74Anorexia (HP:0002039)2.26102941
75Prostate neoplasm (HP:0100787)2.25821559
76IgM deficiency (HP:0002850)2.25181656
77Acute hepatic failure (HP:0006554)2.25171111
78Hypoproteinemia (HP:0003075)2.18028668
79Lymphopenia (HP:0001888)2.15414375
80Alveolar cell carcinoma (HP:0006519)2.14081466
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.11428334
82Polyneuropathy (HP:0001271)2.08090896
83Glomerulopathy (HP:0100820)2.08061175
84Colitis (HP:0002583)2.05912442
85Episodic fever (HP:0001954)2.05537977
86Vertigo (HP:0002321)2.05039821
87Skin rash (HP:0000988)2.01395269
88Neoplasm of the tracheobronchial system (HP:0100552)2.01189462
89Cellulitis (HP:0100658)2.00124398
90Joint swelling (HP:0001386)1.98533627
91Peritonitis (HP:0002586)1.93759144
92Systemic lupus erythematosus (HP:0002725)1.92335037
93Keratitis (HP:0000491)1.91200814
94Amyloidosis (HP:0011034)1.90788279
95Osteomyelitis (HP:0002754)1.87452174
96Purpura (HP:0000979)1.85486331
97Verrucae (HP:0200043)1.84173705
98Papilloma (HP:0012740)1.84173705
99Aplastic anemia (HP:0001915)1.83961818
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83628014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.80231646
2RIPK43.48608655
3MAP4K13.40044213
4FES3.13453903
5TAOK33.01452547
6BLK2.71877678
7IKBKE2.42909322
8CSK2.38750946
9TYK22.28321876
10MAP3K142.27828886
11JAK32.20449846
12KIT2.19054656
13SYK2.17302298
14BTK2.14350587
15GRK62.13010372
16ITK2.10976826
17BMPR22.09499992
18IRAK42.07123130
19ZAP702.06315565
20TEC1.99890798
21TBK11.94158518
22IKBKB1.89658706
23HCK1.69001389
24LYN1.63115135
25CSF1R1.60969187
26GRK71.59160953
27TNK21.58219975
28KDR1.57447171
29JAK11.54957384
30LCK1.54727864
31TESK21.51075176
32PIK3CG1.47757851
33MAP2K31.43121384
34FRK1.38864237
35MAP3K131.16466986
36JAK21.13906145
37MATK1.13245377
38CAMKK21.12894668
39TGFBR21.09297270
40MARK31.05549458
41ADRBK21.03346331
42TLK10.96276627
43IRAK10.91970512
44PRKCQ0.91527695
45FGR0.88599655
46MAP3K30.88565561
47MAP3K110.85460699
48PIM10.84019517
49INSRR0.81170831
50STK100.80264912
51SIK30.75416286
52PRPF4B0.73975703
53ERN10.72582359
54TRPM70.71119506
55CHUK0.68122429
56MAPK70.65781911
57PDK10.65372850
58FYN0.58200398
59SIK20.56091496
60PTK2B0.54160014
61HIPK20.51825774
62CAMKK10.51607132
63EPHB10.51564829
64IGF1R0.50638460
65MAP2K60.49707199
66MAP3K10.49249140
67FGFR30.48008979
68ABL10.46536318
69MAP2K20.46418043
70CDK40.44391510
71MAPK120.44293657
72MST40.42994631
73ACVR1B0.41730882
74RPS6KA60.40568065
75IRAK20.40515107
76MAPKAPK20.39218177
77ADRBK10.38447320
78MAP3K60.38405926
79MAPK110.36256379
80MAP3K50.35708527
81NLK0.35328672
82RPS6KC10.35322562
83RPS6KL10.35322562
84EGFR0.34701299
85NUAK10.32638463
86LRRK20.30291503
87MOS0.29987620
88DAPK20.29365732
89GRK50.29032283
90WNK10.28802618
91PDPK10.27783471
92PRKCD0.27302052
93CDK60.26792041
94TAOK20.26604082
95CDK190.25461133
96ZAK0.24634724
97MAPK30.24339501
98MAP3K120.23177382
99NEK60.21707774
100MAPKAPK30.21495511

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.59575767
2Allograft rejection_Homo sapiens_hsa053303.58697445
3Autoimmune thyroid disease_Homo sapiens_hsa053203.35832355
4Primary immunodeficiency_Homo sapiens_hsa053403.34980562
5Asthma_Homo sapiens_hsa053102.98360198
6Leishmaniasis_Homo sapiens_hsa051402.81388329
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.77552716
8Staphylococcus aureus infection_Homo sapiens_hsa051502.72735707
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.67548325
10Type I diabetes mellitus_Homo sapiens_hsa049402.64407731
11Antigen processing and presentation_Homo sapiens_hsa046122.56443292
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.25660054
13Hematopoietic cell lineage_Homo sapiens_hsa046402.20886874
14Osteoclast differentiation_Homo sapiens_hsa043802.20613425
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.12701398
16NF-kappa B signaling pathway_Homo sapiens_hsa040642.05284377
17Rheumatoid arthritis_Homo sapiens_hsa053232.00458714
18T cell receptor signaling pathway_Homo sapiens_hsa046601.95142857
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86845982
20Measles_Homo sapiens_hsa051621.83113746
21Viral myocarditis_Homo sapiens_hsa054161.83074400
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82631207
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80867972
24Tuberculosis_Homo sapiens_hsa051521.79889183
25B cell receptor signaling pathway_Homo sapiens_hsa046621.70085984
26Malaria_Homo sapiens_hsa051441.66989992
27Toxoplasmosis_Homo sapiens_hsa051451.45032873
28Influenza A_Homo sapiens_hsa051641.43991647
29Legionellosis_Homo sapiens_hsa051341.43303024
30Herpes simplex infection_Homo sapiens_hsa051681.41378922
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31452096
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.31286498
33TNF signaling pathway_Homo sapiens_hsa046681.30831733
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29078854
35Chemokine signaling pathway_Homo sapiens_hsa040621.26829626
36Pertussis_Homo sapiens_hsa051331.22054379
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15027006
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12032681
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03734477
40Platelet activation_Homo sapiens_hsa046111.02023722
41Phagosome_Homo sapiens_hsa041450.97037643
42Other glycan degradation_Homo sapiens_hsa005110.96972787
43SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95846448
44African trypanosomiasis_Homo sapiens_hsa051430.92532774
45Shigellosis_Homo sapiens_hsa051310.87644814
46Salmonella infection_Homo sapiens_hsa051320.86651550
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83011853
48Lysosome_Homo sapiens_hsa041420.76292226
49Acute myeloid leukemia_Homo sapiens_hsa052210.75665327
50Hepatitis B_Homo sapiens_hsa051610.74419588
51Systemic lupus erythematosus_Homo sapiens_hsa053220.72877439
52Apoptosis_Homo sapiens_hsa042100.72691424
53Hepatitis C_Homo sapiens_hsa051600.64908488
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64869775
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64428774
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.62921934
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.60019248
58Regulation of autophagy_Homo sapiens_hsa041400.58595387
59Epstein-Barr virus infection_Homo sapiens_hsa051690.57119203
60HTLV-I infection_Homo sapiens_hsa051660.45928128
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45530522
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45206038
63Prolactin signaling pathway_Homo sapiens_hsa049170.39969709
64VEGF signaling pathway_Homo sapiens_hsa043700.39259446
65Non-small cell lung cancer_Homo sapiens_hsa052230.37651536
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37629183
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.37356599
68Dorso-ventral axis formation_Homo sapiens_hsa043200.37302751
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36781199
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.36282931
71Arachidonic acid metabolism_Homo sapiens_hsa005900.35919345
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34905122
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34001169
74Viral carcinogenesis_Homo sapiens_hsa052030.33106131
75Endocytosis_Homo sapiens_hsa041440.33080300
76MAPK signaling pathway_Homo sapiens_hsa040100.30737841
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30573016
78Pancreatic cancer_Homo sapiens_hsa052120.28404999
79Linoleic acid metabolism_Homo sapiens_hsa005910.27019420
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26547775
81Olfactory transduction_Homo sapiens_hsa047400.23922902
82FoxO signaling pathway_Homo sapiens_hsa040680.23253329
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.22391788
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21122101
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.20955395
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20482974
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18620985
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.18286051
89Insulin resistance_Homo sapiens_hsa049310.18038871
90Collecting duct acid secretion_Homo sapiens_hsa049660.17201421
91Amoebiasis_Homo sapiens_hsa051460.16282236
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16188722
93Phototransduction_Homo sapiens_hsa047440.16044105
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15119131
95Morphine addiction_Homo sapiens_hsa050320.14736065
96Complement and coagulation cascades_Homo sapiens_hsa046100.14426327
97HIF-1 signaling pathway_Homo sapiens_hsa040660.13292976
98Renin secretion_Homo sapiens_hsa049240.12708699
99Caffeine metabolism_Homo sapiens_hsa002320.12675252
100Oxytocin signaling pathway_Homo sapiens_hsa049210.12064472

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