CLEC2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.80069248
2keratinocyte proliferation (GO:0043616)8.39014064
3endothelium development (GO:0003158)8.09098242
4regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)8.06873337
5keratinocyte development (GO:0003334)7.96294839
6gap junction assembly (GO:0016264)7.62652310
7negative regulation of cardiac muscle tissue growth (GO:0055022)7.44963170
8negative regulation of heart growth (GO:0061117)7.44963170
9atrial cardiac muscle cell action potential (GO:0086014)7.23566441
10epithelial cell maturation (GO:0002070)7.04275500
11multicellular organismal water homeostasis (GO:0050891)6.98757816
12purine ribonucleotide transport (GO:0015868)6.77210611
13skeletal muscle tissue regeneration (GO:0043403)6.76193509
14regulation of glomerular filtration (GO:0003093)6.68196739
15keratinocyte differentiation (GO:0030216)6.61655054
16lateral sprouting from an epithelium (GO:0060601)6.57763719
17adenine nucleotide transport (GO:0051503)6.53394711
18polarized epithelial cell differentiation (GO:0030859)6.28408641
19regulation of tight junction assembly (GO:2000810)5.93667021
20water homeostasis (GO:0030104)5.78138340
21imidazole-containing compound metabolic process (GO:0052803)5.56512738
22purine nucleotide transport (GO:0015865)5.21218093
23intestinal epithelial cell development (GO:0060576)5.19164265
24epidermal cell differentiation (GO:0009913)4.97941984
25renal system process involved in regulation of blood volume (GO:0001977)4.82349473
26regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.82320207
27negative regulation of cardiac muscle tissue development (GO:0055026)4.79871328
28establishment of planar polarity (GO:0001736)4.70487092
29establishment of tissue polarity (GO:0007164)4.70487092
30epithelial cell differentiation involved in prostate gland development (GO:0060742)4.59486260
31peptide cross-linking (GO:0018149)4.56928934
32chronic inflammatory response (GO:0002544)4.39728105
33regulation of penile erection (GO:0060405)4.15429826
34nucleoside transport (GO:0015858)4.08173120
35epidermis development (GO:0008544)4.07151546
36adult heart development (GO:0007512)3.96359692
37bundle of His cell to Purkinje myocyte communication (GO:0086069)3.93120208
38magnesium ion transport (GO:0015693)3.91376211
39phosphatidylinositol acyl-chain remodeling (GO:0036149)3.86462177
40fatty acid elongation (GO:0030497)3.72880593
41regulation of neuron projection regeneration (GO:0070570)3.68685719
42regulation of axon regeneration (GO:0048679)3.68685719
43regulation of phospholipase A2 activity (GO:0032429)3.68675718
44polyol transport (GO:0015791)3.68103466
45pyrimidine-containing compound transmembrane transport (GO:0072531)3.59116040
46hair follicle morphogenesis (GO:0031069)3.58508920
47icosanoid secretion (GO:0032309)3.57174523
48arachidonic acid secretion (GO:0050482)3.57174523
49poly(A)+ mRNA export from nucleus (GO:0016973)3.49702638
50renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.48481804
51eyelid development in camera-type eye (GO:0061029)3.44364140
52cell communication by electrical coupling (GO:0010644)3.41409405
53reflex (GO:0060004)3.39476058
54negative regulation of organ growth (GO:0046621)3.38954452
55one-carbon compound transport (GO:0019755)3.38432653
56phosphatidylserine acyl-chain remodeling (GO:0036150)3.33146576
57cellular response to arsenic-containing substance (GO:0071243)3.30155391
58nucleotide transport (GO:0006862)3.22857886
59cerebellar Purkinje cell differentiation (GO:0021702)3.18155215
60cornea development in camera-type eye (GO:0061303)3.17803603
61regulation of keratinocyte differentiation (GO:0045616)3.15123530
62phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.14224907
63long-chain fatty acid biosynthetic process (GO:0042759)3.09725561
64sympathetic nervous system development (GO:0048485)3.07908629
65negative regulation of epidermal cell differentiation (GO:0045605)3.07166522
66regulation of germinal center formation (GO:0002634)3.04933272
67localization within membrane (GO:0051668)3.04850718
68molting cycle process (GO:0022404)3.03345200
69hair cycle process (GO:0022405)3.03345200
70genitalia morphogenesis (GO:0035112)2.99104468
71phosphatidylcholine acyl-chain remodeling (GO:0036151)2.96296107
72hair cycle (GO:0042633)2.89274280
73molting cycle (GO:0042303)2.89274280
74lens development in camera-type eye (GO:0002088)2.88023935
75positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.87815998
76mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.87815998
77tissue regeneration (GO:0042246)2.87597838
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.86953554
79T-helper cell differentiation (GO:0042093)2.86953554
80phospholipid catabolic process (GO:0009395)2.86834906
81cell-cell junction assembly (GO:0007043)2.84024072
82phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.83667375
83linoleic acid metabolic process (GO:0043651)2.81499050
84negative regulation of cell aging (GO:0090344)2.81290763
85peptidyl-cysteine modification (GO:0018198)2.79829710
86regulation of cholesterol homeostasis (GO:2000188)2.79205002
87trophectodermal cell differentiation (GO:0001829)2.77991524
88regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.76205588
89hair follicle development (GO:0001942)2.73100652
90regulation of monocyte differentiation (GO:0045655)2.71154433
91fusion of sperm to egg plasma membrane (GO:0007342)2.70729483
92early endosome to late endosome transport (GO:0045022)2.70668080
93fatty acid derivative transport (GO:1901571)2.68007261
94icosanoid transport (GO:0071715)2.68007261
95lung lobe morphogenesis (GO:0060463)2.67531329
96peroxisome fission (GO:0016559)2.66048260
97cardiac muscle cell action potential involved in contraction (GO:0086002)2.65775848
98establishment of skin barrier (GO:0061436)13.5318452
99desmosome organization (GO:0002934)12.2480595
100regulation of water loss via skin (GO:0033561)11.3406621

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.63860292
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.19755842
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.30620617
4FUS_26573619_Chip-Seq_HEK293_Human2.88275332
5* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.49313396
6NRF2_20460467_ChIP-Seq_MEFs_Mouse2.26719582
7NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.26719582
8VDR_22108803_ChIP-Seq_LS180_Human2.20052908
9PIAS1_25552417_ChIP-Seq_VCAP_Human2.19941477
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.16595587
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14723637
12TP63_23658742_ChIP-Seq_EP156T_Human2.13106837
13RXR_22108803_ChIP-Seq_LS180_Human2.12200990
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09360327
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07970143
16TAF15_26573619_Chip-Seq_HEK293_Human2.06249144
17SOX9_24532713_ChIP-Seq_HFSC_Mouse1.97451771
18EGR1_19032775_ChIP-ChIP_M12_Human1.89521278
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82142205
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76428529
21EWS_26573619_Chip-Seq_HEK293_Human1.75880109
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.73445076
23FOXM1_26456572_ChIP-Seq_MCF-7_Human1.71554023
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.68027001
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67274731
26NR3C1_21868756_ChIP-Seq_MCF10A_Human1.66835274
27P53_22127205_ChIP-Seq_FIBROBLAST_Human1.62206265
28AHR_22903824_ChIP-Seq_MCF-7_Human1.59112722
29IGF1R_20145208_ChIP-Seq_DFB_Human1.59062393
30CJUN_26792858_Chip-Seq_BT549_Human1.58405828
31ER_23166858_ChIP-Seq_MCF-7_Human1.58393007
32P300_19829295_ChIP-Seq_ESCs_Human1.52832267
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51593605
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49922422
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49158781
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.45876875
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45092474
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44620900
39TBX3_20139965_ChIP-Seq_ESCs_Mouse1.41833547
40TBX3_20139965_ChIP-Seq_MESCs_Mouse1.40211542
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39062610
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.37946150
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.34540716
44TP53_18474530_ChIP-ChIP_U2OS_Human1.32191007
45RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29452221
46CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29239028
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26876823
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22823565
49GATA1_22025678_ChIP-Seq_K562_Human1.22384355
50TCF4_22108803_ChIP-Seq_LS180_Human1.21037747
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20386988
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19688264
53CDX2_22108803_ChIP-Seq_LS180_Human1.19405475
54AR_21572438_ChIP-Seq_LNCaP_Human1.19096352
55VDR_24787735_ChIP-Seq_THP-1_Human1.17742364
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17134777
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16337271
58SMAD4_21799915_ChIP-Seq_A2780_Human1.14094354
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12481700
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.12388042
61AR_25329375_ChIP-Seq_VCAP_Human1.11842123
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11199806
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10311568
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09953621
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09953621
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08144935
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07806659
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07372214
69CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07165034
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.07066827
71GBX2_23144817_ChIP-Seq_PC3_Human1.06367749
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.04023069
73TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01704352
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01204371
75SOX2_19829295_ChIP-Seq_ESCs_Human1.00464318
76NANOG_19829295_ChIP-Seq_ESCs_Human1.00464318
77FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00249901
78PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00178400
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99865468
80CBP_20019798_ChIP-Seq_JUKART_Human0.99865468
81HTT_18923047_ChIP-ChIP_STHdh_Human0.99836224
82GATA3_24758297_ChIP-Seq_MCF-7_Human0.98510004
83FLI1_21867929_ChIP-Seq_TH2_Mouse0.97912848
84BRD4_25478319_ChIP-Seq_HGPS_Human0.95979831
85BCAT_22108803_ChIP-Seq_LS180_Human0.95960180
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95389565
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95379757
88EP300_21415370_ChIP-Seq_HL-1_Mouse0.95111035
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93968666
90TP63_19390658_ChIP-ChIP_HaCaT_Human0.91504578
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89847969
92PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89253353
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.87775884
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.87520477
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87489802
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87005830
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.86877728
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86788763
99RUNX2_22187159_ChIP-Seq_PCA_Human0.86574457
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85686019

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.91744415
2MP0009379_abnormal_foot_pigmentation6.89147821
3MP0005275_abnormal_skin_tensile5.83322397
4MP0009384_cardiac_valve_regurgitation4.33567574
5MP0005501_abnormal_skin_physiology4.31211046
6MP0000566_synostosis3.32901908
7MP0010234_abnormal_vibrissa_follicle3.18089070
8MP0001188_hyperpigmentation2.78976587
9MP0003279_aneurysm2.64631670
10MP0001542_abnormal_bone_strength2.59714734
11MP0001853_heart_inflammation2.58458450
12MP0001216_abnormal_epidermal_layer2.52617566
13MP0003453_abnormal_keratinocyte_physiol2.43446784
14MP0001984_abnormal_olfaction2.28500624
15MP0004782_abnormal_surfactant_physiolog2.26800012
16MP0002009_preneoplasia2.21979400
17MP0010771_integument_phenotype2.17712211
18MP0002095_abnormal_skin_pigmentation2.12588419
19MP0010678_abnormal_skin_adnexa2.07564778
20MP0000383_abnormal_hair_follicle2.07241979
21MP0005503_abnormal_tendon_morphology1.89852363
22MP0000015_abnormal_ear_pigmentation1.86168639
23MP0005174_abnormal_tail_pigmentation1.83888314
24MP0004947_skin_inflammation1.69625654
25MP0003718_maternal_effect1.69125045
26MP0000427_abnormal_hair_cycle1.68427964
27MP0000465_gastrointestinal_hemorrhage1.64710639
28MP0003941_abnormal_skin_development1.63281831
29MP0000428_abnormal_craniofacial_morphol1.62154633
30MP0004381_abnormal_hair_follicle1.52785916
31MP0002060_abnormal_skin_morphology1.46890172
32MP0008789_abnormal_olfactory_epithelium1.43759713
33MP0001191_abnormal_skin_condition1.40298767
34MP0000750_abnormal_muscle_regeneration1.39577253
35MP0005171_absent_coat_pigmentation1.37674351
36MP0000579_abnormal_nail_morphology1.37486558
37MP0004215_abnormal_myocardial_fiber1.28543064
38MP0009931_abnormal_skin_appearance1.24130867
39MP0003690_abnormal_glial_cell1.23688748
40MP0003011_delayed_dark_adaptation1.23052634
41MP0008438_abnormal_cutaneous_collagen1.17376445
42MP0005394_taste/olfaction_phenotype1.16787754
43MP0005499_abnormal_olfactory_system1.16787754
44MP0000647_abnormal_sebaceous_gland1.16080726
45MP0001440_abnormal_grooming_behavior1.15955664
46MP0000377_abnormal_hair_follicle1.14062577
47MP0002098_abnormal_vibrissa_morphology1.12504929
48MP0005197_abnormal_uvea_morphology1.04612065
49MP0000367_abnormal_coat/_hair1.01309449
50MP0003950_abnormal_plasma_membrane0.98522595
51MP0002638_abnormal_pupillary_reflex0.96278556
52MP0002233_abnormal_nose_morphology0.96199332
53MP0005508_abnormal_skeleton_morphology0.90033723
54MP0003638_abnormal_response/metabolism_0.88129949
55MP0000569_abnormal_digit_pigmentation0.87563142
56MP0004484_altered_response_of0.84595770
57MP0002877_abnormal_melanocyte_morpholog0.80248494
58MP0001784_abnormal_fluid_regulation0.75947517
59MP0002277_abnormal_respiratory_mucosa0.74066257
60MP0005595_abnormal_vascular_smooth0.73387144
61MP0002092_abnormal_eye_morphology0.73110806
62MP0005075_abnormal_melanosome_morpholog0.72275305
63MP0001881_abnormal_mammary_gland0.72152448
64MP0004185_abnormal_adipocyte_glucose0.69651130
65MP0004883_abnormal_blood_vessel0.65670922
66MP0003567_abnormal_fetal_cardiomyocyte0.64781967
67MP0000049_abnormal_middle_ear0.64374293
68MP0000372_irregular_coat_pigmentation0.64282090
69MP0003943_abnormal_hepatobiliary_system0.61246670
70MP0010368_abnormal_lymphatic_system0.60701719
71MP0001851_eye_inflammation0.60355504
72MP0002115_abnormal_skeleton_extremities0.57839046
73MP0010030_abnormal_orbit_morphology0.56669574
74MP0002109_abnormal_limb_morphology0.55524048
75MP0002177_abnormal_outer_ear0.55037175
76MP0009765_abnormal_xenobiotic_induced0.53939859
77MP0001340_abnormal_eyelid_morphology0.53179247
78MP0000462_abnormal_digestive_system0.53118828
79MP0005385_cardiovascular_system_phenoty0.51791466
80MP0001544_abnormal_cardiovascular_syste0.51791466
81MP0009250_abnormal_appendicular_skeleto0.51364934
82MP0002160_abnormal_reproductive_system0.51197874
83MP0000627_abnormal_mammary_gland0.51063127
84MP0009672_abnormal_birth_weight0.50072177
85MP0002166_altered_tumor_susceptibility0.49329630
86MP0005248_abnormal_Harderian_gland0.49311334
87MP0003937_abnormal_limbs/digits/tail_de0.49174858
88MP0001293_anophthalmia0.48876489
89MP0002998_abnormal_bone_remodeling0.48032536
90MP0003137_abnormal_impulse_conducting0.47693256
91MP0003828_pulmonary_edema0.47191847
92MP0005023_abnormal_wound_healing0.47053276
93MP0000230_abnormal_systemic_arterial0.44409584
94MP0001243_abnormal_dermal_layer0.44401444
95MP0005620_abnormal_muscle_contractility0.43387696
96MP0003878_abnormal_ear_physiology0.43308353
97MP0005377_hearing/vestibular/ear_phenot0.43308353
98MP0002282_abnormal_trachea_morphology0.42952299
99MP0005389_reproductive_system_phenotype0.42804106
100MP0009780_abnormal_chondrocyte_physiolo0.40321431

Predicted human phenotypes

RankGene SetZ-score
1Aplasia of the phalanges of the hand (HP:0009802)7.03831893
2Aplasia involving bones of the extremities (HP:0009825)7.03831893
3Aplasia involving bones of the upper limbs (HP:0009823)7.03831893
4Abnormality of the axillary hair (HP:0100134)6.42361657
5Abnormality of secondary sexual hair (HP:0009888)6.42361657
6Short middle phalanx of the 5th finger (HP:0004220)6.00480031
7Hypotrichosis (HP:0001006)5.75022118
8Selective tooth agenesis (HP:0001592)5.66694876
9Erythroderma (HP:0001019)5.57895034
10Long nose (HP:0003189)5.47003936
11Dry hair (HP:0011359)5.27464528
12Increased IgE level (HP:0003212)4.96221282
13Tetraparesis (HP:0002273)4.66137080
14Abnormality of the dental root (HP:0006486)4.47957626
15Taurodontia (HP:0000679)4.47957626
16Abnormality of permanent molar morphology (HP:0011071)4.47957626
17Abnormality of molar morphology (HP:0011070)4.21470363
18Abnormality of molar (HP:0011077)4.21470363
19Fragile nails (HP:0001808)4.10116776
20Abnormality of the dental pulp (HP:0006479)4.05714745
21Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)4.00848992
22Palmoplantar hyperkeratosis (HP:0000972)3.95128435
23Duplicated collecting system (HP:0000081)3.88977864
24Palmar hyperkeratosis (HP:0010765)3.84401646
25Erythema (HP:0010783)3.76099191
26Conjunctival hamartoma (HP:0100780)3.69423941
27Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.68492446
28Broad alveolar ridges (HP:0000187)3.52407706
29Abnormality of the columella (HP:0009929)3.51328650
30Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.41898693
31Abnormality of the renal collecting system (HP:0004742)3.40992411
32Sensory axonal neuropathy (HP:0003390)3.38189760
33Narrow nasal bridge (HP:0000446)3.26474919
34Nasolacrimal duct obstruction (HP:0000579)3.22002303
35Abnormality of the phalanges of the 5th finger (HP:0004213)3.18375246
36Congenital ichthyosiform erythroderma (HP:0007431)3.15724684
37Mixed hearing impairment (HP:0000410)3.15206541
38Short 5th finger (HP:0009237)3.14372007
39Plantar hyperkeratosis (HP:0007556)3.10322969
40Short hallux (HP:0010109)3.05687776
41Hypoplastic left heart (HP:0004383)3.03020264
42Woolly hair (HP:0002224)3.02027541
43Atrioventricular block (HP:0001678)3.01889308
44Alopecia of scalp (HP:0002293)2.99595135
45Hypoplastic labia majora (HP:0000059)2.99300287
46Conical tooth (HP:0000698)2.97918091
47Lip pit (HP:0100267)2.91606399
48Absent eyelashes (HP:0000561)2.91399131
49Split foot (HP:0001839)2.89723944
50Thick nail (HP:0001805)2.89572650
51Slow-growing hair (HP:0002217)2.86896319
52Abnormality of hair growth rate (HP:0011363)2.86896319
53Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.86672992
54Sparse scalp hair (HP:0002209)2.86441511
55Curly hair (HP:0002212)2.84432937
56Corneal erosion (HP:0200020)2.82426161
57Aplasia/Hypoplasia of the hallux (HP:0008362)2.79102470
58Median cleft lip (HP:0000161)2.75958208
59Abnormality of the labia majora (HP:0012881)2.70403966
60Abnormality of the lacrimal duct (HP:0011481)2.63669621
61Abnormality of the nasolacrimal system (HP:0000614)2.54955418
62Premature loss of primary teeth (HP:0006323)2.50481338
63Palmoplantar keratoderma (HP:0000982)2.48998263
64Maternal diabetes (HP:0009800)2.48442786
65Oligodontia (HP:0000677)2.46710277
66Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.45170307
67Cutaneous syndactyly (HP:0012725)2.43680992
68Depressed nasal tip (HP:0000437)2.43604723
69Non-midline cleft lip (HP:0100335)2.43572655
70Xerostomia (HP:0000217)2.37276490
71Hypoplastic heart (HP:0001961)2.35623457
72Eczematoid dermatitis (HP:0000976)2.32038070
73Hamartoma of the eye (HP:0010568)2.30816209
74Onycholysis (HP:0001806)2.30017517
75Abnormality of the salivary glands (HP:0010286)2.29330563
76Flared metaphyses (HP:0003015)2.25288928
77Right ventricular cardiomyopathy (HP:0011663)2.24909116
78Abnormality of chromosome segregation (HP:0002916)2.23643630
79Parakeratosis (HP:0001036)2.23480212
80Hypoplasia of dental enamel (HP:0006297)2.21024756
81Absent hair (HP:0002298)2.18830840
82Abnormality of incisor morphology (HP:0011063)2.18541849
83Septate vagina (HP:0001153)2.15449876
84Short middle phalanx of finger (HP:0005819)2.09590705
85Anhidrosis (HP:0000970)2.03395366
86Natal tooth (HP:0000695)2.03350037
87Hamartoma (HP:0010566)2.02596785
88Abnormality of the alveolar ridges (HP:0006477)1.99573429
89Breast hypoplasia (HP:0003187)1.97860730
90Cubitus valgus (HP:0002967)1.92835784
91Abnormality of nail color (HP:0100643)1.91891783
92Sparse eyelashes (HP:0000653)1.89256387
93Melanocytic nevus (HP:0000995)1.85905670
94Basal ganglia calcification (HP:0002135)1.84769357
95Heart block (HP:0012722)1.84139223
96Hypohidrosis (HP:0000966)1.83583687
97Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.82634433
98Craniofacial hyperostosis (HP:0004493)1.82080618
99Ureteral duplication (HP:0000073)1.81802372
100Hyporeflexia of lower limbs (HP:0002600)1.80028478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK248.92976635
2FRK3.93686736
3TGFBR13.86344862
4MAPK73.41962560
5MAPK123.33962816
6TAF13.09654243
7PIK3CG2.49797889
8KIT2.36911398
9BRSK22.29447375
10STK32.26220255
11EEF2K2.25384365
12MKNK22.05308388
13MAP3K62.03066066
14MAPKAPK51.82913425
15FGFR11.81359845
16NUAK11.81118235
17FGFR21.79752713
18MAPKAPK31.67506005
19PRKCE1.62633654
20MKNK11.62236914
21RPS6KB11.42175280
22EIF2AK21.36829792
23MAP3K21.34600805
24BMPR1B1.31709843
25MAP3K31.31614466
26DMPK1.29391558
27TGFBR21.20341231
28PRKCG1.20101487
29BRD41.18005348
30GRK71.04823108
31SRPK10.97625469
32MAP2K60.94894141
33TRPM70.93637818
34FGFR30.87619740
35RPS6KA40.87608457
36RPS6KB20.87403050
37CAMKK20.83872648
38PIK3CA0.83026762
39NEK90.80443326
40MAP2K40.77675032
41VRK20.70520085
42GRK50.70420843
43SGK20.68855742
44ADRBK10.67275712
45CDC70.65789170
46TAOK30.64354116
47FER0.63991353
48CSNK1D0.63697791
49MOS0.63350227
50SMG10.63254705
51VRK10.59236043
52RPS6KA50.59229196
53IKBKB0.58655620
54IRAK10.56850437
55CDK30.56183181
56DYRK30.53873784
57NLK0.51649215
58PINK10.51022935
59STK110.48856907
60MAPK90.46162362
61CDK60.46140751
62MINK10.46130887
63ILK0.45334710
64IRAK20.44908738
65STK100.43781183
66GSK3A0.42419403
67PLK20.41914017
68LRRK20.41907000
69STK38L0.39757439
70MAPKAPK20.38326654
71FLT30.38270110
72AKT30.35020260
73IGF1R0.34117102
74CASK0.34094463
75ACVR1B0.33912968
76MAPK130.32904524
77AURKA0.32858554
78WNK30.32553406
79MAPK40.32297267
80MAPK30.32179149
81DYRK1A0.31083441
82PRKCQ0.30722650
83MAP2K30.30325631
84ERBB30.30107018
85MTOR0.29359134
86CDK90.28989349
87RAF10.28798769
88SGK10.28083974
89MAP3K70.27545464
90SGK4940.26491706
91SGK2230.26491706
92SGK30.24004360
93PRKAA20.23929245
94ABL10.23682626
95MAPK110.23184877
96PRKCD0.20636080
97MAPK10.19832989
98DAPK30.18009134
99MAPK100.17687993
100BCR0.17356858

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.15534268
2Histidine metabolism_Homo sapiens_hsa003403.80195798
3Linoleic acid metabolism_Homo sapiens_hsa005913.59032651
4Sphingolipid metabolism_Homo sapiens_hsa006003.35421157
5Circadian rhythm_Homo sapiens_hsa047102.75135681
6Ether lipid metabolism_Homo sapiens_hsa005652.65157986
7Dorso-ventral axis formation_Homo sapiens_hsa043202.56650846
8Staphylococcus aureus infection_Homo sapiens_hsa051502.33204542
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.20329296
10p53 signaling pathway_Homo sapiens_hsa041151.89045979
11Arachidonic acid metabolism_Homo sapiens_hsa005901.87919016
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79304584
13Hedgehog signaling pathway_Homo sapiens_hsa043401.60968881
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59523196
15Basal cell carcinoma_Homo sapiens_hsa052171.44698239
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30371677
17Inositol phosphate metabolism_Homo sapiens_hsa005621.28919609
18Choline metabolism in cancer_Homo sapiens_hsa052311.28489647
19Renin secretion_Homo sapiens_hsa049241.26517522
20Amoebiasis_Homo sapiens_hsa051461.22190371
21Phototransduction_Homo sapiens_hsa047441.21006713
22ECM-receptor interaction_Homo sapiens_hsa045121.18387916
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16799628
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.15049720
25Long-term depression_Homo sapiens_hsa047301.07719114
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04316902
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.03901551
28Sphingolipid signaling pathway_Homo sapiens_hsa040711.03131235
29Systemic lupus erythematosus_Homo sapiens_hsa053221.00680513
30Platelet activation_Homo sapiens_hsa046111.00281746
31GnRH signaling pathway_Homo sapiens_hsa049120.99433925
32Renin-angiotensin system_Homo sapiens_hsa046140.98777063
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98446059
34Fatty acid elongation_Homo sapiens_hsa000620.97907437
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97517805
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96351750
37Serotonergic synapse_Homo sapiens_hsa047260.95883163
38Oxytocin signaling pathway_Homo sapiens_hsa049210.95101534
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94124656
40Olfactory transduction_Homo sapiens_hsa047400.93031135
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88686209
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.87212893
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85781999
44Asthma_Homo sapiens_hsa053100.84697013
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84604381
46Ras signaling pathway_Homo sapiens_hsa040140.84535083
47Ovarian steroidogenesis_Homo sapiens_hsa049130.84458998
48Wnt signaling pathway_Homo sapiens_hsa043100.82552632
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.79081981
50MicroRNAs in cancer_Homo sapiens_hsa052060.77551055
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75922815
52Glutamatergic synapse_Homo sapiens_hsa047240.75562063
53Nitrogen metabolism_Homo sapiens_hsa009100.75272031
54Gap junction_Homo sapiens_hsa045400.70818271
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.70620597
56Salivary secretion_Homo sapiens_hsa049700.70562811
57Pancreatic secretion_Homo sapiens_hsa049720.69598209
58Peroxisome_Homo sapiens_hsa041460.69487199
59Alcoholism_Homo sapiens_hsa050340.67883792
60Hepatitis C_Homo sapiens_hsa051600.67708479
61RNA degradation_Homo sapiens_hsa030180.66744263
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.66029207
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65817281
64ABC transporters_Homo sapiens_hsa020100.65628703
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64927505
66VEGF signaling pathway_Homo sapiens_hsa043700.64780245
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64746631
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.64565238
69MAPK signaling pathway_Homo sapiens_hsa040100.63060517
70Melanogenesis_Homo sapiens_hsa049160.60992366
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60179263
72AMPK signaling pathway_Homo sapiens_hsa041520.53956383
73Chemical carcinogenesis_Homo sapiens_hsa052040.52745450
74Calcium signaling pathway_Homo sapiens_hsa040200.52488098
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52441726
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51989890
77Retinol metabolism_Homo sapiens_hsa008300.51081423
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50806739
79Pancreatic cancer_Homo sapiens_hsa052120.50043438
80Endocytosis_Homo sapiens_hsa041440.49069984
81Antigen processing and presentation_Homo sapiens_hsa046120.49019910
82Regulation of autophagy_Homo sapiens_hsa041400.46055568
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45842494
84Vitamin digestion and absorption_Homo sapiens_hsa049770.45743135
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44932506
86Protein digestion and absorption_Homo sapiens_hsa049740.44450019
87Fanconi anemia pathway_Homo sapiens_hsa034600.44102416
88Gastric acid secretion_Homo sapiens_hsa049710.43431582
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41203927
90Hippo signaling pathway_Homo sapiens_hsa043900.39522758
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39201237
92Tuberculosis_Homo sapiens_hsa051520.38420782
93Herpes simplex infection_Homo sapiens_hsa051680.35326011
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34998146
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34752280
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34529598
97HTLV-I infection_Homo sapiens_hsa051660.34226856
98Influenza A_Homo sapiens_hsa051640.33013395
99Dopaminergic synapse_Homo sapiens_hsa047280.32172607
100Hematopoietic cell lineage_Homo sapiens_hsa046400.31572268

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