CLEC1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)6.75702207
2vascular endothelial growth factor signaling pathway (GO:0038084)6.69684612
3surfactant homeostasis (GO:0043129)6.40030822
4blood vessel maturation (GO:0001955)6.23310053
5positive regulation of vasculogenesis (GO:2001214)5.86868129
6lymphangiogenesis (GO:0001946)5.86513768
7regulation of endothelial cell differentiation (GO:0045601)5.44952544
8retina vasculature morphogenesis in camera-type eye (GO:0061299)5.23607055
9endothelium development (GO:0003158)5.22226249
10regulation of vasculogenesis (GO:2001212)5.18605792
11cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.09864306
12piRNA metabolic process (GO:0034587)5.09603343
13morphogenesis of an endothelium (GO:0003159)5.02575585
14endothelial tube morphogenesis (GO:0061154)5.02575585
15chemical homeostasis within a tissue (GO:0048875)4.84637019
16synapsis (GO:0007129)4.79090243
17negative regulation of nitric-oxide synthase activity (GO:0051001)4.66873995
18definitive hemopoiesis (GO:0060216)4.62618606
19sprouting angiogenesis (GO:0002040)4.53071206
20positive regulation of endothelial cell differentiation (GO:0045603)4.50054614
21endothelial cell differentiation (GO:0045446)4.28600028
22male meiosis I (GO:0007141)4.24776591
23substrate-dependent cell migration (GO:0006929)4.24622339
24vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.05014834
25platelet dense granule organization (GO:0060155)4.01813311
26DNA methylation involved in gamete generation (GO:0043046)3.97814575
27regulation of sarcomere organization (GO:0060297)3.88000848
28response to pheromone (GO:0019236)3.87481101
29behavioral response to nicotine (GO:0035095)3.78510239
30venous blood vessel morphogenesis (GO:0048845)3.78128124
31regulation of memory T cell differentiation (GO:0043380)3.65173227
32vascular smooth muscle contraction (GO:0014829)3.58546614
33male meiosis (GO:0007140)3.54132885
34facial nerve structural organization (GO:0021612)3.52377425
35cornea development in camera-type eye (GO:0061303)3.52298990
36endothelial cell morphogenesis (GO:0001886)3.51352391
37glomerular filtration (GO:0003094)3.49051751
38negative regulation of nitric oxide biosynthetic process (GO:0045019)3.46598272
39response to interferon-beta (GO:0035456)3.44361809
40detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.44177123
41regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.43227196
42endothelial cell chemotaxis (GO:0035767)3.40233834
43basement membrane organization (GO:0071711)3.37841047
44response to interferon-alpha (GO:0035455)3.36985229
45patterning of blood vessels (GO:0001569)3.35906793
46artery development (GO:0060840)3.34772238
47renal filtration (GO:0097205)3.34638424
48regulation of metalloenzyme activity (GO:0048552)3.34294343
49meiosis I (GO:0007127)3.31460466
50detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.31154495
51detection of temperature stimulus involved in sensory perception (GO:0050961)3.31154495
52mesodermal cell differentiation (GO:0048333)3.31143218
53negative regulation of endothelial cell proliferation (GO:0001937)3.27051893
54angiogenesis involved in wound healing (GO:0060055)3.26934024
55negative regulation of mast cell activation (GO:0033004)3.26835412
56cell migration involved in sprouting angiogenesis (GO:0002042)3.25042105
57vasculogenesis (GO:0001570)3.23392064
58fucose catabolic process (GO:0019317)3.22484719
59L-fucose metabolic process (GO:0042354)3.22484719
60L-fucose catabolic process (GO:0042355)3.22484719
61endocrine hormone secretion (GO:0060986)3.18915049
62retinal cone cell development (GO:0046549)3.18099119
63neuron projection extension involved in neuron projection guidance (GO:1902284)3.17101871
64axon extension involved in axon guidance (GO:0048846)3.17101871
65blood vessel remodeling (GO:0001974)3.16687842
66regulation of relaxation of muscle (GO:1901077)3.15687327
67negative regulation of monooxygenase activity (GO:0032769)3.14753627
68thyroid hormone metabolic process (GO:0042403)3.14676466
69negative regulation of endothelial cell apoptotic process (GO:2000352)3.14296964
70negative regulation of systemic arterial blood pressure (GO:0003085)3.09107806
71acrosome assembly (GO:0001675)3.08560303
72negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.08154019
73sulfation (GO:0051923)3.07286504
74blood vessel endothelial cell migration (GO:0043534)3.06011770
75megakaryocyte development (GO:0035855)3.03558217
76regulation of hippo signaling (GO:0035330)3.01954704
77establishment of endothelial barrier (GO:0061028)2.99621033
78phospholipid scrambling (GO:0017121)2.99468272
79membrane raft organization (GO:0031579)2.98685097
80ganglion development (GO:0061548)2.97855802
81positive regulation of smooth muscle cell migration (GO:0014911)2.97810841
82wound healing, spreading of epidermal cells (GO:0035313)2.94566087
83negative regulation of endothelial cell migration (GO:0010596)2.94497702
84phagocytosis, recognition (GO:0006910)2.93660342
85artery smooth muscle contraction (GO:0014824)2.92659389
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.92155977
87negative regulation of stress fiber assembly (GO:0051497)2.90396658
88neural tube formation (GO:0001841)2.90044656
89epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89904615
90adaptation of signaling pathway (GO:0023058)2.88999009
91antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87173131
92antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.87173131
93negative regulation of blood vessel endothelial cell migration (GO:0043537)2.87130209
94positive regulation of respiratory burst (GO:0060267)2.85446295
95thyroid hormone generation (GO:0006590)2.85278878
96phosphatidylinositol acyl-chain remodeling (GO:0036149)2.82113333
97chromosome organization involved in meiosis (GO:0070192)2.77077696
98indolalkylamine metabolic process (GO:0006586)2.76504253
99ovulation from ovarian follicle (GO:0001542)2.76412623
100negative regulation of vascular permeability (GO:0043116)2.73110730
101positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.70994225
102regulation of endothelial cell migration (GO:0010594)2.70662705
103negative regulation of platelet activation (GO:0010544)2.69578651
104growth hormone receptor signaling pathway (GO:0060396)2.68689039
105peptidyl-tyrosine autophosphorylation (GO:0038083)2.68560898
106positive regulation of meiotic cell cycle (GO:0051446)2.68535726
107coronary vasculature morphogenesis (GO:0060977)2.67769190
108negative regulation of Rho protein signal transduction (GO:0035024)2.65583139
109secretory granule organization (GO:0033363)2.65566488
110mRNA transcription from RNA polymerase II promoter (GO:0042789)2.65359805
111cell adhesion mediated by integrin (GO:0033627)2.64437816
112somite development (GO:0061053)2.63675562
113norepinephrine metabolic process (GO:0042415)2.63179551
114regulation of meiosis I (GO:0060631)2.62517628
115thrombin receptor signaling pathway (GO:0070493)2.61765462
116positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.60924676
117detection of light stimulus involved in sensory perception (GO:0050962)2.60518700
118detection of light stimulus involved in visual perception (GO:0050908)2.60518700
119regulation of endothelial cell proliferation (GO:0001936)2.59385945
120regulation of cardiac muscle cell contraction (GO:0086004)2.59316342
121axoneme assembly (GO:0035082)2.58427277
122heart trabecula formation (GO:0060347)2.58014335
123endothelial cell proliferation (GO:0001935)2.57384643
124reciprocal meiotic recombination (GO:0007131)2.57001289
125reciprocal DNA recombination (GO:0035825)2.57001289
126cAMP biosynthetic process (GO:0006171)2.56905078
127cilium or flagellum-dependent cell motility (GO:0001539)2.56279129
128embryonic hemopoiesis (GO:0035162)2.55942891
129positive regulation of macrophage cytokine production (GO:0060907)2.55655821
130regulation of blood vessel endothelial cell migration (GO:0043535)2.55391903
131photoreceptor cell maintenance (GO:0045494)2.55227006
132positive regulation of endothelial cell proliferation (GO:0001938)2.55142913
133negative regulation of protein autophosphorylation (GO:0031953)2.55096060
134interkinetic nuclear migration (GO:0022027)2.54680808
135positive regulation of lipid kinase activity (GO:0090218)2.53438756
136indole-containing compound catabolic process (GO:0042436)2.53006043
137indolalkylamine catabolic process (GO:0046218)2.53006043
138tryptophan catabolic process (GO:0006569)2.53006043
139gonadal mesoderm development (GO:0007506)2.52861504
140positive regulation of focal adhesion assembly (GO:0051894)2.52503138
141positive regulation of cell junction assembly (GO:1901890)2.52503138
142activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.51379662
143antigen processing and presentation of endogenous antigen (GO:0019883)2.50386141
144embryonic heart tube development (GO:0035050)2.50296511
145positive regulation of defense response to virus by host (GO:0002230)2.49941180
146protein K11-linked deubiquitination (GO:0035871)2.49293751
147negative regulation of actin filament bundle assembly (GO:0032232)2.48936808
148cellular extravasation (GO:0045123)2.48927198
149superoxide anion generation (GO:0042554)2.48558269
150phasic smooth muscle contraction (GO:0014821)2.48512101
151regulation of endothelial cell apoptotic process (GO:2000351)2.48493016
152transcytosis (GO:0045056)2.48446659
153positive regulation of endothelial cell migration (GO:0010595)2.48330221
154positive regulation of cardiac muscle cell differentiation (GO:2000727)2.48296764
155DNA deamination (GO:0045006)2.48030275
156positive regulation of blood coagulation (GO:0030194)2.47561683
157positive regulation of hemostasis (GO:1900048)2.47561683
158detection of temperature stimulus (GO:0016048)2.47534634
159negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46437336
160positive regulation of meiosis (GO:0045836)2.45949338
161Notch signaling involved in heart development (GO:0061314)2.45495444
162regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.45375741
163neuronal action potential (GO:0019228)2.44975560
164negative regulation of macrophage differentiation (GO:0045650)2.44362569
165regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.43971274
166limb bud formation (GO:0060174)2.42668524
167regulation of cilium movement (GO:0003352)2.42544310
168amine catabolic process (GO:0009310)2.42458527
169cellular biogenic amine catabolic process (GO:0042402)2.42458527
170tonic smooth muscle contraction (GO:0014820)2.42250802
171tyrosine phosphorylation of STAT protein (GO:0007260)2.40831158
172plasma membrane fusion (GO:0045026)2.40757250
173cell wall macromolecule catabolic process (GO:0016998)2.40694899
174positive regulation of T-helper 1 type immune response (GO:0002827)2.40067463
175cilium morphogenesis (GO:0060271)2.38962369
176endoderm formation (GO:0001706)2.38853540
177auditory receptor cell stereocilium organization (GO:0060088)2.37464424
178regulation of T-helper 1 type immune response (GO:0002825)2.37370879
179cAMP catabolic process (GO:0006198)2.36802629
180auditory receptor cell differentiation (GO:0042491)2.35114158
181positive regulation of prostaglandin secretion (GO:0032308)2.32813121
182establishment of protein localization to Golgi (GO:0072600)2.31955361
183positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.31946090
184kidney morphogenesis (GO:0060993)2.30219973
185histamine secretion (GO:0001821)2.25069348
186indole-containing compound metabolic process (GO:0042430)2.24971626
187meiotic nuclear division (GO:0007126)2.24838136
188fusion of sperm to egg plasma membrane (GO:0007342)2.23010789
189cyclic nucleotide catabolic process (GO:0009214)2.19413912
190regulation of sequestering of triglyceride (GO:0010889)2.19107923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.49564106
2GATA2_21666600_ChIP-Seq_HMVEC_Human4.25033033
3GATA1_22025678_ChIP-Seq_K562_Human3.92599310
4SCL_19346495_ChIP-Seq_HPC-7_Human3.08382812
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06934424
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.01106725
7ZNF274_21170338_ChIP-Seq_K562_Hela2.90458654
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.83502005
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66518311
10VDR_22108803_ChIP-Seq_LS180_Human2.64571695
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.62982909
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.59959094
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47197351
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47072392
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46469699
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29737105
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.13480437
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.10330477
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07729123
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.07408890
21CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.02868216
22P300_19829295_ChIP-Seq_ESCs_Human2.02249917
23CLOCK_20551151_ChIP-Seq_293T_Human2.01525709
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94018953
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.89939740
26ER_23166858_ChIP-Seq_MCF-7_Human1.85897619
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83286977
28EZH2_22144423_ChIP-Seq_EOC_Human1.82393969
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78996363
30IGF1R_20145208_ChIP-Seq_DFB_Human1.76521392
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75928000
32RUNX_20019798_ChIP-Seq_JUKART_Human1.75876294
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75625830
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.72179483
35EWS_26573619_Chip-Seq_HEK293_Human1.72147404
36CJUN_26792858_Chip-Seq_BT549_Human1.71113004
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.70411852
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67911437
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66188044
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.64664949
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64304586
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63307819
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.63235386
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59828978
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.59567729
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56491078
47* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56401923
48FUS_26573619_Chip-Seq_HEK293_Human1.55780454
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.55746149
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55653347
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.54738856
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53983375
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53160161
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.52536451
55SMAD4_21799915_ChIP-Seq_A2780_Human1.52220527
56SOX2_20726797_ChIP-Seq_SW620_Human1.52097381
57AR_25329375_ChIP-Seq_VCAP_Human1.50549636
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49633406
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49415583
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48039094
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46807150
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.46371970
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46151266
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.46104249
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45788307
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45556971
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.44699187
68TCF4_23295773_ChIP-Seq_U87_Human1.43209212
69STAT3_23295773_ChIP-Seq_U87_Human1.42672158
70TCF4_22108803_ChIP-Seq_LS180_Human1.42118793
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41314686
72RUNX2_22187159_ChIP-Seq_PCA_Human1.40957147
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39929759
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.39769116
75CBP_20019798_ChIP-Seq_JUKART_Human1.39666614
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39666614
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39527028
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39400410
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37776244
80GATA1_19941826_ChIP-Seq_K562_Human1.37707365
81IRF1_19129219_ChIP-ChIP_H3396_Human1.37525324
82RNF2_27304074_Chip-Seq_NSC_Mouse1.37016890
83TBX20_22328084_ChIP-Seq_HEART_Mouse1.35743776
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.35743776
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35264824
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.34946572
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.33481985
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33191621
89* TP53_22573176_ChIP-Seq_HFKS_Human1.32938102
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31990884
91NANOG_19829295_ChIP-Seq_ESCs_Human1.31708094
92SOX2_19829295_ChIP-Seq_ESCs_Human1.31708094
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29791122
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.29479866
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29322533
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29322533
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.28313164
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.27968319
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.27493054
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25572412
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.25340930
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.25216968
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.24364270
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23823865
105MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23183171
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.22921383
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22889567
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.22215741
109* FOXA1_25329375_ChIP-Seq_VCAP_Human1.21941024
110* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21941024
111* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21798957
112* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21798957
113PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21597849
114* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21502084
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21423591
116* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21215686
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19521563
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19521563
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19334458
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.18719110
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18398169
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.18006539
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17338375
124ESR2_21235772_ChIP-Seq_MCF-7_Human1.16683480
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15907073
126PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14569896
127GATA2_19941826_ChIP-Seq_K562_Human1.14427391
128CDX2_22108803_ChIP-Seq_LS180_Human1.14153733
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12670558
130EED_16625203_ChIP-ChIP_MESCs_Mouse1.11984817
131TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11033346
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10914413
133LXR_22158963_ChIP-Seq_LIVER_Mouse1.10652350
134GATA3_21878914_ChIP-Seq_MCF-7_Human1.10111467
135OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09781997
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09103171
137BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08487524
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08327531
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08262218
140* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08198119
141RXR_22108803_ChIP-Seq_LS180_Human1.07580301
142STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07440013
143CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06406666
144SPI1_23127762_ChIP-Seq_K562_Human1.06218446
145* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.06062809
146SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05645992
147BCAT_22108803_ChIP-Seq_LS180_Human1.05332182
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04471572
149PIAS1_25552417_ChIP-Seq_VCAP_Human1.04208658
150VDR_24787735_ChIP-Seq_THP-1_Human1.02833361
151P53_22387025_ChIP-Seq_ESCs_Mouse1.02684592
152EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01733692
153GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01532254
154STAT3_18555785_Chip-Seq_ESCs_Mouse1.01250874
155* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99841132
156HTT_18923047_ChIP-ChIP_STHdh_Human0.99829643
157CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98588315
158SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98494864
159RXR_22158963_ChIP-Seq_LIVER_Mouse0.98288511
160TAL1_26923725_Chip-Seq_HPCs_Mouse0.97883992
161KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96966662
162PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96928574
163LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96135460
164AR_20517297_ChIP-Seq_VCAP_Human0.95455237
165AHR_22903824_ChIP-Seq_MCF-7_Human0.94864178
166SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94664646
167SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93880368
168FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93492793
169JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92472098
170TP53_18474530_ChIP-ChIP_U2OS_Human0.91256593
171SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91078970
172BRD4_25478319_ChIP-Seq_HGPS_Human0.89219682
173PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88522235
174SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88395806
175VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87129545
176HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86873482
177TP63_23658742_ChIP-Seq_EP156T_Human0.85118710
178NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83469040
179GBX2_23144817_ChIP-Seq_PC3_Human0.83009999
180TAF15_26573619_Chip-Seq_HEK293_Human0.82653935
181ARNT_22903824_ChIP-Seq_MCF-7_Human0.82607924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.40082632
2MP0001879_abnormal_lymphatic_vessel5.77394792
3MP0008877_abnormal_DNA_methylation4.60531653
4MP0005167_abnormal_blood-brain_barrier4.17818477
5MP0003724_increased_susceptibility_to4.06926765
6MP0003195_calcinosis3.59547217
7MP0004272_abnormal_basement_membrane3.35491847
8MP0003828_pulmonary_edema3.22407284
9MP0002876_abnormal_thyroid_physiology2.90765675
10MP0002138_abnormal_hepatobiliary_system2.74188764
11MP0004147_increased_porphyrin_level2.54778161
12MP0001958_emphysema2.50632174
13MP0002102_abnormal_ear_morphology2.46560048
14MP0003191_abnormal_cellular_cholesterol2.44041279
15MP0000569_abnormal_digit_pigmentation2.42294951
16MP0009379_abnormal_foot_pigmentation2.33056532
17MP0003787_abnormal_imprinting2.17864753
18MP0003279_aneurysm2.17620488
19MP0002332_abnormal_exercise_endurance2.12738991
20MP0005551_abnormal_eye_electrophysiolog2.10572816
21MP0004084_abnormal_cardiac_muscle2.09318299
22MP0000767_abnormal_smooth_muscle2.08120658
23MP0004782_abnormal_surfactant_physiolog2.05117752
24MP0004510_myositis2.01078671
25MP0003950_abnormal_plasma_membrane1.98350142
26MP0001501_abnormal_sleep_pattern1.96323229
27MP0005075_abnormal_melanosome_morpholog1.95653667
28MP0005171_absent_coat_pigmentation1.94839891
29MP0004742_abnormal_vestibular_system1.91907674
30MP0006138_congestive_heart_failure1.91281215
31MP0006054_spinal_hemorrhage1.87362293
32MP0001968_abnormal_touch/_nociception1.77075154
33MP0000465_gastrointestinal_hemorrhage1.73497958
34MP0002837_dystrophic_cardiac_calcinosis1.71740117
35MP0005360_urolithiasis1.71158839
36MP0009278_abnormal_bone_marrow1.70104728
37MP0005165_increased_susceptibility_to1.67899086
38MP0005174_abnormal_tail_pigmentation1.67758615
39MP0008872_abnormal_physiological_respon1.65605829
40MP0000343_altered_response_to1.64790077
41MP0005085_abnormal_gallbladder_physiolo1.55124437
42MP0000249_abnormal_blood_vessel1.51016191
43MP0003011_delayed_dark_adaptation1.50999627
44MP0001486_abnormal_startle_reflex1.49938907
45MP0001485_abnormal_pinna_reflex1.47174574
46MP0008995_early_reproductive_senescence1.46986551
47MP0003300_gastrointestinal_ulcer1.45846700
48MP0004036_abnormal_muscle_relaxation1.45054940
49MP0001835_abnormal_antigen_presentation1.43723792
50MP0006276_abnormal_autonomic_nervous1.43418085
51MP0004484_altered_response_of1.42161830
52MP0002160_abnormal_reproductive_system1.41906886
53MP0000427_abnormal_hair_cycle1.40196929
54MP0003646_muscle_fatigue1.36842355
55MP0005389_reproductive_system_phenotype1.34046256
56MP0004885_abnormal_endolymph1.33750790
57MP0002128_abnormal_blood_circulation1.33088639
58MP0004215_abnormal_myocardial_fiber1.31440897
59MP0005464_abnormal_platelet_physiology1.31319481
60MP0001544_abnormal_cardiovascular_syste1.30590111
61MP0005385_cardiovascular_system_phenoty1.30590111
62MP0009785_altered_susceptibility_to1.30572498
63MP0009780_abnormal_chondrocyte_physiolo1.29674049
64MP0005595_abnormal_vascular_smooth1.29162437
65MP0003880_abnormal_central_pattern1.28922531
66MP0003705_abnormal_hypodermis_morpholog1.27334459
67MP0000372_irregular_coat_pigmentation1.26767215
68MP0003045_fibrosis1.26002946
69MP0009764_decreased_sensitivity_to1.25425268
70MP0003566_abnormal_cell_adhesion1.25372832
71MP0005253_abnormal_eye_physiology1.23946516
72MP0009745_abnormal_behavioral_response1.21978834
73MP0005397_hematopoietic_system_phenotyp1.21773408
74MP0001545_abnormal_hematopoietic_system1.21773408
75MP0005084_abnormal_gallbladder_morpholo1.20486642
76MP0001853_heart_inflammation1.18013061
77MP0005646_abnormal_pituitary_gland1.15084040
78MP0002210_abnormal_sex_determination1.15037869
79MP0004145_abnormal_muscle_electrophysio1.14712196
80MP0002166_altered_tumor_susceptibility1.13516868
81MP0002272_abnormal_nervous_system1.12103587
82MP0002938_white_spotting1.11884573
83MP0005310_abnormal_salivary_gland1.11644455
84MP0008775_abnormal_heart_ventricle1.10973705
85MP0003633_abnormal_nervous_system1.10908077
86MP0002972_abnormal_cardiac_muscle1.10508681
87MP0005164_abnormal_response_to1.09631846
88MP0004883_abnormal_blood_vessel1.08651510
89MP0002736_abnormal_nociception_after1.08507923
90MP0003941_abnormal_skin_development1.07562734
91MP0005388_respiratory_system_phenotype1.06573586
92MP0002133_abnormal_respiratory_system1.06573586
93MP0002733_abnormal_thermal_nociception1.06169671
94MP0001188_hyperpigmentation1.05987791
95MP0004808_abnormal_hematopoietic_stem1.04880143
96MP0005409_darkened_coat_color1.04304331
97MP0001919_abnormal_reproductive_system1.03888938
98MP0001970_abnormal_pain_threshold1.03564755
99MP0006082_CNS_inflammation1.03267328
100MP0001614_abnormal_blood_vessel1.02256290
101MP0005330_cardiomyopathy1.02142664
102MP0003943_abnormal_hepatobiliary_system1.01325584
103MP0010630_abnormal_cardiac_muscle1.00947961
104MP0002254_reproductive_system_inflammat1.00427319
105MP0002638_abnormal_pupillary_reflex0.99941940
106MP0000631_abnormal_neuroendocrine_gland0.99013056
107MP0003121_genomic_imprinting0.96012693
108MP0001929_abnormal_gametogenesis0.95419774
109MP0002127_abnormal_cardiovascular_syste0.95336672
110MP0001851_eye_inflammation0.94366168
111MP0002925_abnormal_cardiovascular_devel0.94281536
112MP0002095_abnormal_skin_pigmentation0.93990567
113MP0002295_abnormal_pulmonary_circulatio0.93745741
114MP0003303_peritoneal_inflammation0.92184650
115MP0000647_abnormal_sebaceous_gland0.90370873
116MP0000516_abnormal_urinary_system0.90120682
117MP0005367_renal/urinary_system_phenotyp0.90120682
118MP0003091_abnormal_cell_migration0.89125585
119MP0002168_other_aberrant_phenotype0.89082132
120MP0009697_abnormal_copulation0.87959671
121MP0003698_abnormal_male_reproductive0.86860555
122MP0000653_abnormal_sex_gland0.86487125
123MP0001986_abnormal_taste_sensitivity0.86350288
124MP0004130_abnormal_muscle_cell0.85136117
125MP0005670_abnormal_white_adipose0.84486549
126MP0005025_abnormal_response_to0.84327430
127MP0004085_abnormal_heartbeat0.83763310
128MP0008875_abnormal_xenobiotic_pharmacok0.83606536
129MP0000230_abnormal_systemic_arterial0.82938655
130MP0000383_abnormal_hair_follicle0.82770166
131MP0009046_muscle_twitch0.81068400
132MP0002877_abnormal_melanocyte_morpholog0.80347715
133MP0005387_immune_system_phenotype0.80078557
134MP0001790_abnormal_immune_system0.80078557
135MP0001145_abnormal_male_reproductive0.79782724
136MP0002396_abnormal_hematopoietic_system0.79341893
137MP0003638_abnormal_response/metabolism_0.78380438
138MP0003567_abnormal_fetal_cardiomyocyte0.78129759
139MP0005620_abnormal_muscle_contractility0.77789130
140MP0001119_abnormal_female_reproductive0.77707086
141MP0008004_abnormal_stomach_pH0.77596778
142MP0002419_abnormal_innate_immunity0.77440162
143MP0010155_abnormal_intestine_physiology0.76937155
144MP0002067_abnormal_sensory_capabilities0.75888238
145MP0002148_abnormal_hypersensitivity_rea0.75658949
146MP0005410_abnormal_fertilization0.75331148
147MP0008438_abnormal_cutaneous_collagen0.74744283
148MP0005365_abnormal_bile_salt0.72476135
149MP0001533_abnormal_skeleton_physiology0.71092995
150MP0005408_hypopigmentation0.70976919
151MP0002064_seizures0.70230962
152MP0004133_heterotaxia0.70116884
153MP0000681_abnormal_thyroid_gland0.70071626
154MP0005623_abnormal_meninges_morphology0.69619407
155MP0006072_abnormal_retinal_apoptosis0.67860006
156MP0001873_stomach_inflammation0.67264145
157MP0003448_altered_tumor_morphology0.66991208
158MP0003075_altered_response_to0.66535336
159MP0001175_abnormal_lung_morphology0.66112859
160MP0005195_abnormal_posterior_eye0.65901703
161MP0005379_endocrine/exocrine_gland_phen0.63991150
162MP0000685_abnormal_immune_system0.63942051
163MP0005671_abnormal_response_to0.63806376
164MP0002006_tumorigenesis0.63608078
165MP0000015_abnormal_ear_pigmentation0.63042100
166MP0000266_abnormal_heart_morphology0.62571695

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)6.26337596
2Hematochezia (HP:0002573)6.12568072
3Polycythemia (HP:0001901)6.00659906
4Hyperventilation (HP:0002883)4.80308015
5Abnormality of the nasal mucosa (HP:0000433)4.40157477
6Esophageal varix (HP:0002040)4.24736417
7Growth hormone excess (HP:0000845)3.86936520
8Congenital stationary night blindness (HP:0007642)3.82827436
9Prolonged bleeding time (HP:0003010)3.82782123
10Interstitial pulmonary disease (HP:0006530)3.78702054
11Portal hypertension (HP:0001409)3.70881898
12Oligodactyly (hands) (HP:0001180)3.61247461
13Pancreatic cysts (HP:0001737)3.52966999
14Nephronophthisis (HP:0000090)3.51266152
15Abnormality of midbrain morphology (HP:0002418)3.46135665
16Molar tooth sign on MRI (HP:0002419)3.46135665
17Cerebral hemorrhage (HP:0001342)3.42514273
18Abnormality of the hepatic vasculature (HP:0006707)3.36763207
19Stomatitis (HP:0010280)3.31419416
20Abnormality of the renal medulla (HP:0100957)3.29360105
21Abnormality of the renal cortex (HP:0011035)3.25769525
22Conjunctival telangiectasia (HP:0000524)3.22972981
23Pancreatic fibrosis (HP:0100732)3.13298241
24Congenital, generalized hypertrichosis (HP:0004540)3.12048522
25Pulmonary hypertension (HP:0002092)3.07148307
26Mucosal telangiectasiae (HP:0100579)2.94784036
27Abnormality of the vasculature of the conjunctiva (HP:0008054)2.94772771
28Joint hemorrhage (HP:0005261)2.90890764
29Microcytic anemia (HP:0001935)2.89725053
30Reduced subcutaneous adipose tissue (HP:0003758)2.89477321
31Tubular atrophy (HP:0000092)2.85577869
32Inability to walk (HP:0002540)2.82548346
33Increased corneal curvature (HP:0100692)2.80249988
34Keratoconus (HP:0000563)2.80249988
35Abnormal rod and cone electroretinograms (HP:0008323)2.74629944
36Fair hair (HP:0002286)2.73687350
37Widely spaced teeth (HP:0000687)2.73606156
38Abnormality of the intrinsic pathway (HP:0010989)2.71676492
39Epistaxis (HP:0000421)2.71081367
40Broad metatarsal (HP:0001783)2.69638462
41Hemorrhage of the eye (HP:0011885)2.69297204
42Retrobulbar optic neuritis (HP:0100654)2.68141144
43Optic neuritis (HP:0100653)2.68141144
44Atrial fibrillation (HP:0005110)2.67103479
45Ventricular tachycardia (HP:0004756)2.65388196
46True hermaphroditism (HP:0010459)2.65377146
47Bone cyst (HP:0012062)2.64639431
48Gaze-evoked nystagmus (HP:0000640)2.63113983
49Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62164538
50Pulmonary artery stenosis (HP:0004415)2.60836179
51Deep venous thrombosis (HP:0002625)2.60687873
52Medial flaring of the eyebrow (HP:0010747)2.59178503
53Abnormal platelet function (HP:0011869)2.58550924
54Impaired platelet aggregation (HP:0003540)2.58550924
55Broad-based gait (HP:0002136)2.57707417
56Pulmonary embolism (HP:0002204)2.56863062
57Tetraparesis (HP:0002273)2.55230431
58Abolished electroretinogram (ERG) (HP:0000550)2.55139495
59Pendular nystagmus (HP:0012043)2.53836249
60Attenuation of retinal blood vessels (HP:0007843)2.53765640
61Large for gestational age (HP:0001520)2.53491613
62Supraventricular arrhythmia (HP:0005115)2.52861227
63Lymphangioma (HP:0100764)2.52593528
64Cerebral aneurysm (HP:0004944)2.50942709
65Nonimmune hydrops fetalis (HP:0001790)2.49437192
66Visceral angiomatosis (HP:0100761)2.48355039
67Absent speech (HP:0001344)2.47684008
68Clumsiness (HP:0002312)2.47298451
69Gonadotropin excess (HP:0000837)2.47151810
70Hemangiomatosis (HP:0007461)2.46926644
71Menorrhagia (HP:0000132)2.46264022
72Hyperactive renin-angiotensin system (HP:0000841)2.46097186
73Thrombocytosis (HP:0001894)2.45887631
74Primary atrial arrhythmia (HP:0001692)2.44087353
75Abnormal drinking behavior (HP:0030082)2.43762572
76Polydipsia (HP:0001959)2.43762572
77Arterial thrombosis (HP:0004420)2.43210036
78Progressive inability to walk (HP:0002505)2.43199254
79Hyperpituitarism (HP:0010514)2.40706447
80Eczematoid dermatitis (HP:0000976)2.35064629
81Generalized hypopigmentation of hair (HP:0011358)2.33877190
82Supraventricular tachycardia (HP:0004755)2.32216463
83Lipoatrophy (HP:0100578)2.30568095
84Congenital hepatic fibrosis (HP:0002612)2.30113830
85Polyuria (HP:0000103)2.29872686
86Chondrocalcinosis (HP:0000934)2.28868162
87Thyroid-stimulating hormone excess (HP:0002925)2.27843786
88Thrombophlebitis (HP:0004418)2.27526552
89Volvulus (HP:0002580)2.26941136
90Abnormality of Sharpey fibers (HP:0100685)2.26071164
91Decreased central vision (HP:0007663)2.24212757
92Type II lissencephaly (HP:0007260)2.23796452
93Cavernous hemangioma (HP:0001048)2.22533498
94Aplasia/Hypoplasia of the tibia (HP:0005772)2.21943752
95Hemoptysis (HP:0002105)2.19579262
96Aortic aneurysm (HP:0004942)2.18944574
97Glucose intolerance (HP:0000833)2.18864980
98Constricted visual fields (HP:0001133)2.16831482
99Oligodactyly (HP:0012165)2.16285724
100Facial shape deformation (HP:0011334)2.14782472
101Potter facies (HP:0002009)2.14782472
102Febrile seizures (HP:0002373)2.13888472
103Adactyly (HP:0009776)2.12730933
104Porencephaly (HP:0002132)2.12637262
105Elevated erythrocyte sedimentation rate (HP:0003565)2.11909029
106Hemiparesis (HP:0001269)2.11010372
107Camptodactyly of toe (HP:0001836)2.10887304
108Abnormality of secondary sexual hair (HP:0009888)2.10076095
109Abnormality of the axillary hair (HP:0100134)2.10076095
110Facial diplegia (HP:0001349)2.09959866
111Renal cortical cysts (HP:0000803)2.09582570
112Large hands (HP:0001176)2.09406231
113Intestinal atresia (HP:0011100)2.09395874
114Aortic valve stenosis (HP:0001650)2.05885540
115Spontaneous abortion (HP:0005268)2.04586144
116Congenital sensorineural hearing impairment (HP:0008527)2.02877974
117Pigmentary retinal degeneration (HP:0001146)2.02814234
118Keratoconjunctivitis (HP:0001096)2.02719122
119Chronic hepatic failure (HP:0100626)2.01051816
120Thyroiditis (HP:0100646)1.97280648
121Gingival bleeding (HP:0000225)1.97111169
122Orchitis (HP:0100796)1.96565512
123Absent hand (HP:0004050)1.96445788
124Absent eyebrow (HP:0002223)1.95468322
125Fatigue (HP:0012378)1.95175202
126Myositis (HP:0100614)1.94825097
127Amyloidosis (HP:0011034)1.94733785
128Cerebral palsy (HP:0100021)1.94426070
129Protruding tongue (HP:0010808)1.94079501
130Abnormality of the renal collecting system (HP:0004742)1.93280617
131Woolly hair (HP:0002224)1.92491862
132Increased connective tissue (HP:0009025)1.92234501
133Flexion contracture of toe (HP:0005830)1.92233007
134Joint contractures involving the joints of the feet (HP:0100492)1.92233007
135Hypercholesterolemia (HP:0003124)1.91631914
136Enlarged penis (HP:0000040)1.90928452
137Cystic liver disease (HP:0006706)1.90458484
138Sudden death (HP:0001699)1.89962765
139Methylmalonic aciduria (HP:0012120)1.88020749
140Hypokalemic alkalosis (HP:0001949)1.86460336
141Hyperglycinuria (HP:0003108)1.86384808
142Drooling (HP:0002307)1.85889471
143Accelerated skeletal maturation (HP:0005616)1.84998298
144Acanthosis nigricans (HP:0000956)1.84954192
145Decreased circulating renin level (HP:0003351)1.84281103
146Abnormal urine output (HP:0012590)1.83427733
147Right ventricular cardiomyopathy (HP:0011663)1.83203418
148Gait imbalance (HP:0002141)1.82717398
149Bony spicule pigmentary retinopathy (HP:0007737)1.81825677
150Short tibia (HP:0005736)1.81451047
151Lymphedema (HP:0001004)1.81093880
152Congenital primary aphakia (HP:0007707)1.80698739
153Bulbous nose (HP:0000414)1.80630512
154Keratoconjunctivitis sicca (HP:0001097)1.80039297
155Arterial tortuosity (HP:0005116)1.79896424
156Vascular tortuosity (HP:0004948)1.78044729
157Optic nerve hypoplasia (HP:0000609)1.77666409
158Skull defect (HP:0001362)1.77520392
159Abnormal glucose tolerance (HP:0001952)1.77375297
160Metabolic alkalosis (HP:0200114)1.77016836
161Esophageal neoplasm (HP:0100751)1.76863826
162Neoplasm of head and neck (HP:0012288)1.76863826
163Duplicated collecting system (HP:0000081)1.76610911
164Chest pain (HP:0100749)1.76372021
165Male pseudohermaphroditism (HP:0000037)1.74691080
166Pachygyria (HP:0001302)1.74238291
167Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73862883
168Muscle fiber splitting (HP:0003555)1.73836205
169Atrioventricular block (HP:0001678)1.73497158
170Follicular hyperkeratosis (HP:0007502)1.73345949
171Genital tract atresia (HP:0001827)1.73131159
172Purpura (HP:0000979)1.72985879
173Aplasia cutis congenita (HP:0001057)1.72046613
174Abnormality of alanine metabolism (HP:0010916)1.71730355
175Hyperalaninemia (HP:0003348)1.71730355
176Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71730355
177Excessive salivation (HP:0003781)1.71664885
178Azoospermia (HP:0000027)1.71330494
179Vertigo (HP:0002321)1.70554116
180Cerebral ischemia (HP:0002637)1.70546712
181Lissencephaly (HP:0001339)1.70299983
182Genetic anticipation (HP:0003743)1.68979504
183Ectopic kidney (HP:0000086)1.68660286
184Sclerocornea (HP:0000647)1.67983367
185Bilateral sensorineural hearing impairment (HP:0008619)1.67975674
186Agitation (HP:0000713)1.67742481
187Prominent supraorbital ridges (HP:0000336)1.67335663
188Abnormality of renal excretion (HP:0011036)1.67326493
189Dynein arm defect of respiratory motile cilia (HP:0012255)1.67168379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.60787496
2KDR5.19572968
3TGFBR24.34465773
4TGFBR13.51623715
5ADRBK22.82194158
6MYLK2.23461763
7MAPK132.20942680
8TXK2.20854942
9RIPK11.89496555
10WNK31.85964032
11GRK11.83371297
12MAP4K21.83003134
13PNCK1.80327779
14FGFR31.67540696
15MAP3K121.65048322
16MUSK1.62509762
17PINK11.61076149
18OXSR11.58148556
19PAK31.56520736
20EPHB11.55601644
21FER1.53083494
22FGFR41.46692746
23ZAK1.46682409
24PTK2B1.31805199
25INSRR1.31178452
26EPHB21.30963547
27TNIK1.30461813
28TAOK31.29900406
29MAP2K31.29893814
30EPHA31.28715077
31ADRBK11.27559338
32TAF11.26369856
33TEC1.26288255
34KIT1.24580510
35MAP3K141.19208024
36DMPK1.18843057
37NEK91.15875562
38STK391.15756947
39BMPR1B1.14315398
40MAPKAPK31.10543676
41IKBKE0.99777704
42TBK10.99512938
43LRRK20.99456966
44CSK0.97653597
45MAPK120.96758593
46CCNB10.92449655
47ITK0.91614717
48PRKG20.90470468
49MATK0.87602584
50ERN10.86258985
51MAP3K40.85920459
52CAMKK20.85877713
53PIK3CA0.85475106
54NLK0.85332864
55DAPK20.84950906
56CSNK1G10.83591971
57JAK10.83432284
58CSNK1G20.82464314
59PRKCQ0.82149626
60SIK30.80777610
61WNK40.79374120
62TTN0.78962197
63MARK30.77788527
64ZAP700.76145610
65GRK70.75986169
66JAK30.75361907
67PAK40.74459600
68PDK20.72703383
69IRAK10.71417036
70PRKCH0.70215798
71CDK80.69817172
72TYK20.69208493
73NTRK30.68354318
74STK38L0.67623979
75AKT30.65796972
76PTK60.65379206
77MAP3K30.65299948
78PKN10.64935440
79MAP4K10.64504392
80PDGFRA0.63747717
81PKN20.63092909
82PLK20.62865860
83FRK0.62535799
84EIF2AK30.60293966
85CSNK1G30.60169964
86GRK50.59774929
87STK100.58405547
88IKBKB0.58319282
89BLK0.58019063
90PRKCG0.55131550
91MAP3K130.54155640
92CSNK1A1L0.52946839
93LCK0.52075128
94MAPK70.51728447
95CHUK0.50970316
96TYRO30.49889668
97SGK20.48844214
98TRPM70.48651593
99PRKD30.47050521
100PRKD10.46763710
101TLK10.45710769
102PRKAA20.45173529
103STK240.44882920
104CAMK1G0.44580834
105MST40.44293026
106PDPK10.44237975
107PHKG20.43281922
108PHKG10.43281922
109MKNK20.43149617
110IGF1R0.42407959
111PDK10.42249776
112NUAK10.42142243
113MAP2K60.40679897
114FES0.39421051
115MARK10.39255380
116PRKCE0.39092093
117PRKD20.39076088
118OBSCN0.38095200
119LYN0.37788166
120MAPK40.37732265
121CSF1R0.36864766
122TRIM280.36664618
123ABL10.35986245
124MAP2K20.35553880
125BTK0.35299473
126ILK0.35076186
127PDGFRB0.34843744
128SIK10.34070316
129JAK20.33407800
130STK110.33191097
131PRKG10.33144848
132YES10.32923071
133SIK20.32664359
134MAP3K10.31786443
135IRAK40.31565738
136CAMK1D0.30791823
137HCK0.30366701
138TNK20.30139831
139CAMK2A0.29807416
140ACVR1B0.29651671
141CAMK10.29371220
142SYK0.29065192
143CDK90.28349150
144CASK0.27804081
145ROCK10.27748621
146SRC0.27633680
147CAMK40.27622212
148MAPK150.27210644
149LMTK20.27018927
150MAPKAPK50.26472380
151BCKDK0.26314351
152EGFR0.25470731

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005912.89535749
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.83720583
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.64872793
4Phototransduction_Homo sapiens_hsa047442.56041879
5Selenocompound metabolism_Homo sapiens_hsa004502.53346052
6ECM-receptor interaction_Homo sapiens_hsa045122.50174761
7Complement and coagulation cascades_Homo sapiens_hsa046102.32053138
8Focal adhesion_Homo sapiens_hsa045102.28480921
9Platelet activation_Homo sapiens_hsa046112.20644116
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.17177133
11Nitrogen metabolism_Homo sapiens_hsa009102.15709172
12Leukocyte transendothelial migration_Homo sapiens_hsa046702.14239765
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.13019367
14Malaria_Homo sapiens_hsa051442.03212325
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.02572076
16Ether lipid metabolism_Homo sapiens_hsa005652.00305789
17Dilated cardiomyopathy_Homo sapiens_hsa054141.85481331
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85380911
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.84239094
20Viral myocarditis_Homo sapiens_hsa054161.65084398
21Hematopoietic cell lineage_Homo sapiens_hsa046401.62802181
22Adherens junction_Homo sapiens_hsa045201.61248020
23Caffeine metabolism_Homo sapiens_hsa002321.60471990
24Ovarian steroidogenesis_Homo sapiens_hsa049131.59210525
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58779300
26Rap1 signaling pathway_Homo sapiens_hsa040151.57995715
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52639025
28Staphylococcus aureus infection_Homo sapiens_hsa051501.51961579
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.50442547
30Regulation of autophagy_Homo sapiens_hsa041401.50258701
31Leishmaniasis_Homo sapiens_hsa051401.44695161
32African trypanosomiasis_Homo sapiens_hsa051431.44002604
33Toxoplasmosis_Homo sapiens_hsa051451.42222860
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39697390
35Butanoate metabolism_Homo sapiens_hsa006501.39299147
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.38899292
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.38876922
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.37650454
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.37604560
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37518990
41Protein export_Homo sapiens_hsa030601.35996242
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33590903
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.33099895
44Morphine addiction_Homo sapiens_hsa050321.30248734
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30162487
46Pertussis_Homo sapiens_hsa051331.27404711
47Osteoclast differentiation_Homo sapiens_hsa043801.26643886
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25860259
49PI3K-Akt signaling pathway_Homo sapiens_hsa041511.25229959
50Nicotine addiction_Homo sapiens_hsa050331.25176182
51Arachidonic acid metabolism_Homo sapiens_hsa005901.20262011
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19119217
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18675151
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.17690727
55ABC transporters_Homo sapiens_hsa020101.14730190
56Taste transduction_Homo sapiens_hsa047421.14712954
57Salmonella infection_Homo sapiens_hsa051321.14607866
58Small cell lung cancer_Homo sapiens_hsa052221.14350328
59TNF signaling pathway_Homo sapiens_hsa046681.12407483
60Intestinal immune network for IgA production_Homo sapiens_hsa046721.12067968
61Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11794209
62Olfactory transduction_Homo sapiens_hsa047401.10226196
63Basal transcription factors_Homo sapiens_hsa030221.10201061
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08781721
65Autoimmune thyroid disease_Homo sapiens_hsa053201.07180792
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07151653
67PPAR signaling pathway_Homo sapiens_hsa033201.05416887
68Notch signaling pathway_Homo sapiens_hsa043301.04676882
69Rheumatoid arthritis_Homo sapiens_hsa053231.04120756
70Proteoglycans in cancer_Homo sapiens_hsa052051.03876946
71Amoebiasis_Homo sapiens_hsa051461.02655647
72Measles_Homo sapiens_hsa051621.02605777
73Vascular smooth muscle contraction_Homo sapiens_hsa042701.01413462
74Fatty acid degradation_Homo sapiens_hsa000710.99288736
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98566599
76Serotonergic synapse_Homo sapiens_hsa047260.96699909
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95094707
78Renin secretion_Homo sapiens_hsa049240.92791320
79Ras signaling pathway_Homo sapiens_hsa040140.92194623
80beta-Alanine metabolism_Homo sapiens_hsa004100.91609528
81B cell receptor signaling pathway_Homo sapiens_hsa046620.90091353
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89631816
83Homologous recombination_Homo sapiens_hsa034400.88289388
84Collecting duct acid secretion_Homo sapiens_hsa049660.88156048
85Shigellosis_Homo sapiens_hsa051310.87972635
86Chemical carcinogenesis_Homo sapiens_hsa052040.87322056
87Glycerolipid metabolism_Homo sapiens_hsa005610.87090878
88HIF-1 signaling pathway_Homo sapiens_hsa040660.85149317
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83785189
90Mineral absorption_Homo sapiens_hsa049780.83718956
91Peroxisome_Homo sapiens_hsa041460.83180751
92Dorso-ventral axis formation_Homo sapiens_hsa043200.81790317
93Pathways in cancer_Homo sapiens_hsa052000.80380601
94Asthma_Homo sapiens_hsa053100.78356720
95Tryptophan metabolism_Homo sapiens_hsa003800.77735888
96Insulin resistance_Homo sapiens_hsa049310.77598902
97Glutamatergic synapse_Homo sapiens_hsa047240.76339512
98Influenza A_Homo sapiens_hsa051640.76126045
99Circadian rhythm_Homo sapiens_hsa047100.75081237
100Hepatitis C_Homo sapiens_hsa051600.74353003
101Hedgehog signaling pathway_Homo sapiens_hsa043400.74047042
102Circadian entrainment_Homo sapiens_hsa047130.73573479
103Chemokine signaling pathway_Homo sapiens_hsa040620.73433583
104Acute myeloid leukemia_Homo sapiens_hsa052210.72225282
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72173162
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71403871
107Sulfur metabolism_Homo sapiens_hsa009200.71259270
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71245448
109Gastric acid secretion_Homo sapiens_hsa049710.70268686
110Calcium signaling pathway_Homo sapiens_hsa040200.69233650
111Oxidative phosphorylation_Homo sapiens_hsa001900.68863358
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68412088
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68411023
114Apoptosis_Homo sapiens_hsa042100.68368696
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67693887
116GABAergic synapse_Homo sapiens_hsa047270.67398577
117Propanoate metabolism_Homo sapiens_hsa006400.66072869
118Insulin secretion_Homo sapiens_hsa049110.65664772
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65500113
120Axon guidance_Homo sapiens_hsa043600.64750199
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.64328226
122VEGF signaling pathway_Homo sapiens_hsa043700.64122431
123Salivary secretion_Homo sapiens_hsa049700.63938257
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62271878
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.61621106
126Prolactin signaling pathway_Homo sapiens_hsa049170.60750037
127Allograft rejection_Homo sapiens_hsa053300.60663039
128Tight junction_Homo sapiens_hsa045300.58095090
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56382822
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.56273766
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55810284
132Oxytocin signaling pathway_Homo sapiens_hsa049210.54327030
133Vitamin digestion and absorption_Homo sapiens_hsa049770.52423276
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.52347354
135TGF-beta signaling pathway_Homo sapiens_hsa043500.51652046
136T cell receptor signaling pathway_Homo sapiens_hsa046600.51099755
137Fatty acid elongation_Homo sapiens_hsa000620.50951005
138Endocytosis_Homo sapiens_hsa041440.50816241
139Phospholipase D signaling pathway_Homo sapiens_hsa040720.49525231
140cAMP signaling pathway_Homo sapiens_hsa040240.48842217
141Hepatitis B_Homo sapiens_hsa051610.48366710
142Graft-versus-host disease_Homo sapiens_hsa053320.48059312
143Fanconi anemia pathway_Homo sapiens_hsa034600.47760309
144Phagosome_Homo sapiens_hsa041450.47648549
145Pancreatic cancer_Homo sapiens_hsa052120.46124672
146Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45294326
147Histidine metabolism_Homo sapiens_hsa003400.44455631
148Primary immunodeficiency_Homo sapiens_hsa053400.44444859
149Fatty acid metabolism_Homo sapiens_hsa012120.42876257
150Long-term depression_Homo sapiens_hsa047300.42826960
151Fat digestion and absorption_Homo sapiens_hsa049750.42559186
152Bile secretion_Homo sapiens_hsa049760.42414746
153Tuberculosis_Homo sapiens_hsa051520.41978326
154Herpes simplex infection_Homo sapiens_hsa051680.41488668
155Basal cell carcinoma_Homo sapiens_hsa052170.41077688
156Renal cell carcinoma_Homo sapiens_hsa052110.40835747
157Antigen processing and presentation_Homo sapiens_hsa046120.40776441
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40515098
159Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40488590
160Legionellosis_Homo sapiens_hsa051340.39532964
161Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39188297
162Retinol metabolism_Homo sapiens_hsa008300.36636425

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