CLEC18C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gastrulation (GO:2000543)6.57667326
2spinal cord association neuron differentiation (GO:0021527)6.42584410
3gamma-aminobutyric acid transport (GO:0015812)5.87348542
4synaptic vesicle endocytosis (GO:0048488)5.86038403
5neuronal stem cell maintenance (GO:0097150)5.79179259
6glycolytic process (GO:0006096)4.68635301
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.65883750
8vitamin D metabolic process (GO:0042359)4.64776452
9planar cell polarity pathway involved in neural tube closure (GO:0090179)4.44502676
10sequestering of actin monomers (GO:0042989)4.42935188
11epithelial cilium movement (GO:0003351)4.39888094
12glucose 6-phosphate metabolic process (GO:0051156)4.36595378
13short-term memory (GO:0007614)4.28678044
14regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.24550030
15positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)4.00721220
16protein retention in ER lumen (GO:0006621)3.86958123
17peptidyl-proline hydroxylation (GO:0019511)3.73354609
18convergent extension (GO:0060026)3.72863126
19calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.72736566
20mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.68817737
21positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.68817737
22regulation of timing of cell differentiation (GO:0048505)3.68360223
23cilium movement (GO:0003341)3.68155132
24positive regulation of mesonephros development (GO:0061213)3.67392987
254-hydroxyproline metabolic process (GO:0019471)3.65411372
26left/right pattern formation (GO:0060972)3.63769570
27regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.56249791
28nonmotile primary cilium assembly (GO:0035058)3.55061160
29negative regulation of axon guidance (GO:1902668)3.51513048
30midbrain development (GO:0030901)3.45444819
31negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.43907669
32regulation of development, heterochronic (GO:0040034)3.43373481
33dorsal/ventral neural tube patterning (GO:0021904)3.38687082
34lateral sprouting from an epithelium (GO:0060601)3.38444312
35Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.37310117
36neuron fate determination (GO:0048664)3.37170588
37negative regulation of axon extension involved in axon guidance (GO:0048843)3.36216290
38cornea development in camera-type eye (GO:0061303)3.33781556
39nonribosomal peptide biosynthetic process (GO:0019184)3.32513268
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.30715471
41positive regulation of embryonic development (GO:0040019)3.30627822
42regulation of establishment of planar polarity (GO:0090175)3.29825574
43homocysteine metabolic process (GO:0050667)3.28864656
44histone H3-K9 demethylation (GO:0033169)3.25431472
45pyruvate metabolic process (GO:0006090)3.21401941
46post-anal tail morphogenesis (GO:0036342)3.17200537
47Notch receptor processing (GO:0007220)3.15800210
48limb bud formation (GO:0060174)3.15381366
49regulation of axon guidance (GO:1902667)3.13394459
50cell-cell junction maintenance (GO:0045217)3.12928893
51regulation of non-canonical Wnt signaling pathway (GO:2000050)3.11425010
52regulation of collateral sprouting (GO:0048670)3.10718776
53olfactory bulb development (GO:0021772)3.09519594
54dentate gyrus development (GO:0021542)3.08257248
55regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.06288050
56cilium or flagellum-dependent cell motility (GO:0001539)3.03316739
57cochlea morphogenesis (GO:0090103)3.02970691
58protein refolding (GO:0042026)3.01117143
59axonemal dynein complex assembly (GO:0070286)3.00049004
60regulation of axon extension involved in axon guidance (GO:0048841)2.99133925
61positive regulation of protein kinase C signaling (GO:0090037)2.96774578
62regulation of mesenchymal cell apoptotic process (GO:2001053)2.95230341
63negative regulation of astrocyte differentiation (GO:0048712)2.94988590
64cell differentiation in spinal cord (GO:0021515)2.94868044
65cell migration in hindbrain (GO:0021535)2.94753960
66cerebral cortex neuron differentiation (GO:0021895)2.93885151
67urinary tract smooth muscle contraction (GO:0014848)2.93729367
68inositol metabolic process (GO:0006020)2.91440416
69regulation of mesonephros development (GO:0061217)2.89624316
70generation of neurons (GO:0048699)2.88833630
71auditory receptor cell differentiation (GO:0042491)2.88483112
72fructose metabolic process (GO:0006000)2.88247001
73glial cell proliferation (GO:0014009)2.87000461
74mechanoreceptor differentiation (GO:0042490)2.86025479
75receptor guanylyl cyclase signaling pathway (GO:0007168)2.85137413
76positive regulation of receptor internalization (GO:0002092)2.84418622
77fear response (GO:0042596)2.84370644
78hematopoietic stem cell proliferation (GO:0071425)2.81215303
79aldehyde catabolic process (GO:0046185)2.78361698
80negative regulation of neural precursor cell proliferation (GO:2000178)2.78168648
81gluconeogenesis (GO:0006094)2.78115692
82lens fiber cell development (GO:0070307)2.77317729
83behavioral response to ethanol (GO:0048149)2.77263475
84behavioral fear response (GO:0001662)2.76793039
85behavioral defense response (GO:0002209)2.76793039
86G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.76594949
87mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.72292144
88pyrimidine nucleobase catabolic process (GO:0006208)2.70522522
89ribosomal small subunit assembly (GO:0000028)2.69603263
90glutathione biosynthetic process (GO:0006750)2.69384263
91negative regulation of cell fate specification (GO:0009996)2.68611369
92neurotransmitter catabolic process (GO:0042135)2.68496101
93cell proliferation in forebrain (GO:0021846)2.66889395
94mitochondrial DNA replication (GO:0006264)2.66571685
95positive regulation of mitochondrial membrane permeability (GO:0035794)2.64741242
96protein hydroxylation (GO:0018126)2.63515556
97somite development (GO:0061053)2.63364178
98enteric nervous system development (GO:0048484)2.63172001
99layer formation in cerebral cortex (GO:0021819)2.62156435
100glial cell migration (GO:0008347)2.62092634

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.26291820
2HIF1A_21447827_ChIP-Seq_MCF-7_Human4.00564012
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.24789026
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74920244
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.59930291
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.43747446
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.25406371
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.24858414
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20766800
10LXR_22292898_ChIP-Seq_THP-1_Human2.16412520
11EGR1_19032775_ChIP-ChIP_M12_Human2.13642291
12PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.05651182
13SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05252234
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.03751115
15ZNF274_21170338_ChIP-Seq_K562_Hela2.00705129
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.98423495
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93945225
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93092664
19DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.86936962
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86406100
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.83785848
22P68_20966046_ChIP-Seq_HELA_Human1.77467703
23SA1_27219007_Chip-Seq_ERYTHROID_Human1.74999558
24* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.69530589
25CTCF_27219007_Chip-Seq_Bcells_Human1.68748143
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68675816
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.67068965
28YY1_21170310_ChIP-Seq_MESCs_Mouse1.66778870
29TP53_22127205_ChIP-Seq_IMR90_Human1.60390384
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58106664
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58106664
32OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.57152178
33DROSHA_22980978_ChIP-Seq_HELA_Human1.56730656
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56607601
35PHF8_20622854_ChIP-Seq_HELA_Human1.55159266
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53648672
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50315201
38SOX3_22085726_ChIP-Seq_NPCs_Mouse1.49235714
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.45008250
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43035908
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.42346379
42SMC4_20622854_ChIP-Seq_HELA_Human1.41832522
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.41224068
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40832594
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37916029
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.37441983
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.34500553
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33488861
49SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32406496
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31967624
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.30591956
52E2F1_20622854_ChIP-Seq_HELA_Human1.28974557
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27914949
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.26776538
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26761287
56KDM2B_26808549_Chip-Seq_K562_Human1.25109750
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24020288
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23811429
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23440839
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22831892
61* FOXP1_21924763_ChIP-Seq_HESCs_Human1.21921898
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21451303
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20519268
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18263081
65E2F1_17053090_ChIP-ChIP_MCF-7_Human1.17688053
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16957678
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16055444
68SMC3_22415368_ChIP-Seq_MEFs_Mouse1.16049059
69OCT4_19829295_ChIP-Seq_ESCs_Human1.14909299
70RNF2_27304074_Chip-Seq_NSC_Mouse1.13303122
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.12835745
72SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12522467
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11417698
74XRN2_22483619_ChIP-Seq_HELA_Human1.11013843
75CREB1_26743006_Chip-Seq_LNCaP_Human1.10911310
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10544581
77TAF2_19829295_ChIP-Seq_ESCs_Human1.10193253
78BCOR_27268052_Chip-Seq_Bcells_Human1.08446392
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07772420
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07645944
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06486345
82YY1_22570637_ChIP-Seq_MALME-3M_Human1.06215912
83RARA_24833708_ChIP-Seq_LIVER_Mouse1.03684550
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01537317
85TET1_21451524_ChIP-Seq_MESCs_Mouse1.00732498
86SA1_27219007_Chip-Seq_Bcells_Human1.00563848
87MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99689657
88CTCF_21964334_Chip-Seq_Bcells_Human0.99205011
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98231445
90RARB_24833708_ChIP-Seq_LIVER_Mouse0.97842327
91NANOG_21062744_ChIP-ChIP_HESCs_Human0.97642511
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96131967
93SOX2_16153702_ChIP-ChIP_HESCs_Human0.95780391
94TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95551416
95NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.95253443
96CTCF_20526341_ChIP-Seq_ESCs_Human0.94079188
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92351157
98BCL6_27268052_Chip-Seq_Bcells_Human0.92276527
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90901996
100RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90071824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot7.03412291
2MP0003878_abnormal_ear_physiology7.03412291
3MP0010030_abnormal_orbit_morphology4.00509877
4MP0000566_synostosis3.82567773
5MP0002653_abnormal_ependyma_morphology3.20526674
6MP0005171_absent_coat_pigmentation2.89216389
7MP0003136_yellow_coat_color2.78906437
8MP0002736_abnormal_nociception_after2.44665925
9MP0001293_anophthalmia2.42037605
10MP0008004_abnormal_stomach_pH2.40968863
11MP0005499_abnormal_olfactory_system2.14066920
12MP0005394_taste/olfaction_phenotype2.14066920
13MP0005423_abnormal_somatic_nervous2.11717964
14MP0000778_abnormal_nervous_system2.06101388
15MP0001968_abnormal_touch/_nociception2.05390674
16MP0002697_abnormal_eye_size2.04950875
17MP0001958_emphysema1.96308884
18MP0000026_abnormal_inner_ear1.85266594
19MP0008789_abnormal_olfactory_epithelium1.84966202
20MP0006292_abnormal_olfactory_placode1.82146168
21MP0002751_abnormal_autonomic_nervous1.58829455
22MP0005248_abnormal_Harderian_gland1.51133705
23MP0003880_abnormal_central_pattern1.50327574
24MP0004019_abnormal_vitamin_homeostasis1.44487619
25MP0002938_white_spotting1.36270033
26MP0009379_abnormal_foot_pigmentation1.31930681
27MP0000013_abnormal_adipose_tissue1.31402155
28MP0002092_abnormal_eye_morphology1.29391708
29MP0003315_abnormal_perineum_morphology1.27528317
30MP0002233_abnormal_nose_morphology1.26924296
31MP0001270_distended_abdomen1.26698029
32MP0006276_abnormal_autonomic_nervous1.25741569
33MP0003879_abnormal_hair_cell1.21118656
34MP0003938_abnormal_ear_development1.19195222
35MP0001286_abnormal_eye_development1.17623122
36MP0002234_abnormal_pharynx_morphology1.15971151
37MP0002735_abnormal_chemical_nociception1.15339572
38MP0004742_abnormal_vestibular_system1.14423847
39MP0005058_abnormal_lysosome_morphology1.09175427
40MP0008995_early_reproductive_senescence1.09166217
41MP0001984_abnormal_olfaction1.07725085
42MP0006072_abnormal_retinal_apoptosis1.05145191
43MP0000383_abnormal_hair_follicle1.04487092
44MP0001486_abnormal_startle_reflex1.03131392
45MP0002102_abnormal_ear_morphology1.01909557
46MP0005391_vision/eye_phenotype1.01882977
47MP0002249_abnormal_larynx_morphology1.01008623
48MP0002638_abnormal_pupillary_reflex0.99018049
49MP0008877_abnormal_DNA_methylation0.98082322
50MP0002111_abnormal_tail_morphology0.96775924
51MP0002557_abnormal_social/conspecific_i0.94082414
52MP0002295_abnormal_pulmonary_circulatio0.93413222
53MP0003283_abnormal_digestive_organ0.91537099
54MP0001963_abnormal_hearing_physiology0.89975871
55MP0003937_abnormal_limbs/digits/tail_de0.89687557
56MP0001346_abnormal_lacrimal_gland0.89334262
57MP0009384_cardiac_valve_regurgitation0.89080171
58MP0002752_abnormal_somatic_nervous0.88826079
59MP0000049_abnormal_middle_ear0.88444391
60MP0005197_abnormal_uvea_morphology0.87757845
61MP0003221_abnormal_cardiomyocyte_apopto0.86770197
62MP0003632_abnormal_nervous_system0.82194035
63MP0003942_abnormal_urinary_system0.81243143
64MP0000647_abnormal_sebaceous_gland0.81201418
65MP0005195_abnormal_posterior_eye0.81148886
66MP0002572_abnormal_emotion/affect_behav0.80832597
67MP0004859_abnormal_synaptic_plasticity0.79727027
68MP0003861_abnormal_nervous_system0.76517588
69MP0000955_abnormal_spinal_cord0.76488548
70MP0000750_abnormal_muscle_regeneration0.76027231
71MP0004133_heterotaxia0.75732210
72MP0002882_abnormal_neuron_morphology0.74100849
73MP0002089_abnormal_postnatal_growth/wei0.74042451
74MP0002932_abnormal_joint_morphology0.73195410
75MP0002067_abnormal_sensory_capabilities0.72351315
76MP0003755_abnormal_palate_morphology0.70857716
77MP0000372_irregular_coat_pigmentation0.70841562
78MP0003122_maternal_imprinting0.70283380
79MP0002152_abnormal_brain_morphology0.68923902
80MP0005253_abnormal_eye_physiology0.66185015
81MP0002822_catalepsy0.65719187
82MP0001879_abnormal_lymphatic_vessel0.65661781
83MP0002116_abnormal_craniofacial_bone0.64082131
84MP0000003_abnormal_adipose_tissue0.63926238
85MP0001485_abnormal_pinna_reflex0.63790010
86MP0003638_abnormal_response/metabolism_0.63752063
87MP0001324_abnormal_eye_pigmentation0.62779153
88MP0005193_abnormal_anterior_eye0.60868715
89MP0005503_abnormal_tendon_morphology0.59498515
90MP0003137_abnormal_impulse_conducting0.58509600
91MP0003329_amyloid_beta_deposits0.57456496
92MP0000639_abnormal_adrenal_gland0.57352694
93MP0000579_abnormal_nail_morphology0.57119168
94MP0002734_abnormal_mechanical_nocicepti0.57015648
95MP0002075_abnormal_coat/hair_pigmentati0.56420216
96MP0002063_abnormal_learning/memory/cond0.56062256
97MP0009053_abnormal_anal_canal0.55851390
98MP0002184_abnormal_innervation0.54442450
99MP0005551_abnormal_eye_electrophysiolog0.54196929
100MP0003948_abnormal_gas_homeostasis0.52906483

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)7.20143806
2Cholecystitis (HP:0001082)7.20143806
3Amblyopia (HP:0000646)6.25359725
4High anterior hairline (HP:0009890)5.26650595
5Proximal tubulopathy (HP:0000114)5.13644207
6Severe Myopia (HP:0011003)4.47936609
7Partial agenesis of the corpus callosum (HP:0001338)4.41819111
8Nuclear cataract (HP:0100018)4.39041305
9Hypoplastic pelvis (HP:0008839)3.71430056
10Hypoplasia of the iris (HP:0007676)3.71220569
11Vitreoretinal degeneration (HP:0000655)3.42931667
12Turricephaly (HP:0000262)3.37154662
13Wide anterior fontanel (HP:0000260)3.09222017
14Polyphagia (HP:0002591)3.07545120
15Rib fusion (HP:0000902)3.02999426
16Abnormality of glycolysis (HP:0004366)2.95638086
17Vertebral arch anomaly (HP:0008438)2.95036664
18Abnormal respiratory epithelium morphology (HP:0012253)2.89811298
19Abnormal respiratory motile cilium morphology (HP:0005938)2.89811298
20Bicornuate uterus (HP:0000813)2.83557834
21Short 5th finger (HP:0009237)2.67231385
22Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.62812565
23Partial duplication of thumb phalanx (HP:0009944)2.60532464
24True hermaphroditism (HP:0010459)2.55949697
25Atelectasis (HP:0100750)2.51310247
26Chronic hepatic failure (HP:0100626)2.45179309
27Abnormal ciliary motility (HP:0012262)2.43150276
28Prolonged neonatal jaundice (HP:0006579)2.37048683
29Hypoplastic ischia (HP:0003175)2.32254633
30Chorioretinal atrophy (HP:0000533)2.31521956
31Trigonocephaly (HP:0000243)2.26054063
32Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23495749
33Increased corneal curvature (HP:0100692)2.21841371
34Keratoconus (HP:0000563)2.21841371
35Neonatal respiratory distress (HP:0002643)2.21810485
36Partial duplication of the phalanx of hand (HP:0009999)2.17827504
37Abnormal eating behavior (HP:0100738)2.16818922
38Abnormality of midbrain morphology (HP:0002418)2.11481620
39Molar tooth sign on MRI (HP:0002419)2.11481620
40Sprengel anomaly (HP:0000912)2.09894950
41Choroideremia (HP:0001139)2.05644024
42Renal dysplasia (HP:0000110)2.04595629
43Synostosis of carpal bones (HP:0005048)2.02470044
44Ulnar bowing (HP:0003031)2.01701889
45Hyperglycinemia (HP:0002154)2.00676263
46Abnormality of the ischium (HP:0003174)1.98684165
47Thoracic kyphosis (HP:0002942)1.96435660
48Occipital encephalocele (HP:0002085)1.95654526
49Cholelithiasis (HP:0001081)1.95183696
50Gait imbalance (HP:0002141)1.93635651
51Myopathic facies (HP:0002058)1.92037218
52Long nose (HP:0003189)1.91948797
53Bronchomalacia (HP:0002780)1.90895735
54Reticulocytosis (HP:0001923)1.90308755
55Mesangial abnormality (HP:0001966)1.89885603
56Congenital primary aphakia (HP:0007707)1.87457646
57Genital tract atresia (HP:0001827)1.87307280
58Broad thumb (HP:0011304)1.86892163
59Optic nerve coloboma (HP:0000588)1.86469021
60Vaginal atresia (HP:0000148)1.86217766
61Medial flaring of the eyebrow (HP:0010747)1.86147525
62Polydipsia (HP:0001959)1.86102191
63Abnormal drinking behavior (HP:0030082)1.86102191
64Broad metatarsal (HP:0001783)1.84528141
65Cervical subluxation (HP:0003308)1.82453651
66Myokymia (HP:0002411)1.82382918
67Exercise-induced muscle cramps (HP:0003710)1.81736103
68Neonatal short-limb short stature (HP:0008921)1.81451223
69Iris coloboma (HP:0000612)1.81030362
70Abnormal respiratory motile cilium physiology (HP:0012261)1.81021768
71Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80458622
72Short 4th metacarpal (HP:0010044)1.80458622
73Pancreatic fibrosis (HP:0100732)1.77480865
74Broad nasal tip (HP:0000455)1.77264235
75Thin ribs (HP:0000883)1.76814431
76Concave nail (HP:0001598)1.76191278
77Aplasia involving bones of the extremities (HP:0009825)1.76133282
78Aplasia involving bones of the upper limbs (HP:0009823)1.76133282
79Aplasia of the phalanges of the hand (HP:0009802)1.76133282
80Neoplasm of the heart (HP:0100544)1.74655983
81Broad phalanx (HP:0006009)1.74361776
82Hyperglycinuria (HP:0003108)1.73336916
83Zonular cataract (HP:0010920)1.70510076
84Narrow nasal bridge (HP:0000446)1.70294672
85Septo-optic dysplasia (HP:0100842)1.68715430
86Broad long bones (HP:0005622)1.68295290
87Broad forehead (HP:0000337)1.66985387
88Cystic liver disease (HP:0006706)1.66486117
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66334267
90Corneal dystrophy (HP:0001131)1.66262758
91Tented upper lip vermilion (HP:0010804)1.66199417
92Pancreatic cysts (HP:0001737)1.66119472
93Broad finger (HP:0001500)1.65669522
94Abnormal gallbladder morphology (HP:0012437)1.64765066
95Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.64627827
96Vertebral hypoplasia (HP:0008417)1.64627827
97Chorioretinal coloboma (HP:0000567)1.61907774
98Short ribs (HP:0000773)1.61385864
99Delayed epiphyseal ossification (HP:0002663)1.60372211
100Supernumerary bones of the axial skeleton (HP:0009144)1.59300978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.67547346
2BCKDK5.70515286
3EPHA23.12599586
4TESK23.07417377
5MAP2K72.74508599
6DYRK1B2.21430961
7MAP3K62.21348726
8NEK92.11323841
9SIK22.05034958
10MAP2K61.90145281
11FGFR21.87570861
12ADRBK21.82219614
13INSRR1.67565468
14MAP3K41.65199209
15MARK21.61432262
16TLK11.58941863
17CDK191.48844369
18NME11.38216924
19MARK11.37323356
20MAP2K41.35408371
21SIK11.34733270
22NTRK31.33585345
23EPHA31.31870440
24IRAK41.19656487
25MAP3K71.16334868
26PIM21.08805932
27IRAK11.07327579
28EPHB11.07175475
29EPHA41.04992683
30DYRK31.01017977
31EPHB20.97717192
32ERBB30.97230616
33PLK20.95695815
34SIK30.94446688
35DYRK20.94314570
36PINK10.91675345
37CSNK1A1L0.81973307
38KDR0.79182349
39CSK0.79003015
40STK380.74267789
41TNK20.73409657
42MOS0.73035964
43PAK60.72697521
44ERBB20.71033981
45PRKCG0.70354428
46CSNK1G30.67317001
47MAP4K20.65807514
48TYRO30.64828371
49STK110.63942664
50DYRK1A0.63932954
51PKN10.63218120
52PTK2B0.63075600
53BCR0.61035383
54PASK0.59201010
55LRRK20.58886142
56CSNK1G20.57160846
57DDR20.56177990
58FGFR10.53659161
59NTRK20.53017961
60CDK50.52301025
61MAPK100.52009692
62FGR0.51595137
63RPS6KA60.50684051
64CSNK1G10.50361944
65IRAK20.49347629
66BLK0.48786937
67CDK11A0.48718277
68CDK30.48412918
69CDK140.47007230
70PRKAA20.46951463
71DAPK30.46878351
72PAK30.46866459
73RPS6KL10.46591326
74RPS6KC10.46591326
75SGK4940.46374433
76SGK2230.46374433
77SMG10.45567346
78CDK150.45562102
79MAP3K110.45290236
80WNK30.44462206
81CASK0.44435119
82SGK10.43773210
83PRKG10.43757472
84VRK20.43069861
85CDK180.42481664
86ROCK20.41168801
87CAMK10.39556353
88MET0.37711194
89PTK60.37376857
90RET0.36623128
91PRKAA10.34023499
92MAPK130.33642967
93PKN20.32431327
94FLT30.30993436
95PIK3CA0.29631316
96BRD40.29093296
97MAPK80.26936389
98BMX0.25596682
99SRC0.24370746
100CSNK1A10.23272687

Predicted pathways (KEGG)

RankGene SetZ-score
1Hedgehog signaling pathway_Homo sapiens_hsa043404.34486817
2Basal cell carcinoma_Homo sapiens_hsa052173.34480904
3Notch signaling pathway_Homo sapiens_hsa043303.13673856
4Fructose and mannose metabolism_Homo sapiens_hsa000513.07196107
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.86667480
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.74578333
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35351046
8Biosynthesis of amino acids_Homo sapiens_hsa012302.21733596
9Pentose phosphate pathway_Homo sapiens_hsa000302.11279555
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03649082
11Propanoate metabolism_Homo sapiens_hsa006401.98624852
12Arginine and proline metabolism_Homo sapiens_hsa003301.96866993
13Ribosome_Homo sapiens_hsa030101.94347476
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92742381
15Carbon metabolism_Homo sapiens_hsa012001.90980073
16Oxidative phosphorylation_Homo sapiens_hsa001901.86021020
17Nitrogen metabolism_Homo sapiens_hsa009101.74895320
18Galactose metabolism_Homo sapiens_hsa000521.73608991
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.70549395
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.61621502
21Starch and sucrose metabolism_Homo sapiens_hsa005001.57681489
22Parkinsons disease_Homo sapiens_hsa050121.52099945
23Histidine metabolism_Homo sapiens_hsa003401.51428274
24Melanogenesis_Homo sapiens_hsa049161.49088917
25Hippo signaling pathway_Homo sapiens_hsa043901.44607481
26Axon guidance_Homo sapiens_hsa043601.43584166
27Cocaine addiction_Homo sapiens_hsa050301.40478407
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40471987
29Huntingtons disease_Homo sapiens_hsa050161.39570313
30Other glycan degradation_Homo sapiens_hsa005111.39301682
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36496519
32Protein digestion and absorption_Homo sapiens_hsa049741.31154852
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29933296
34Alzheimers disease_Homo sapiens_hsa050101.25218920
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18993051
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14351120
37Thyroid hormone synthesis_Homo sapiens_hsa049181.11265324
38Collecting duct acid secretion_Homo sapiens_hsa049661.09090464
39HIF-1 signaling pathway_Homo sapiens_hsa040661.08138867
40Glutathione metabolism_Homo sapiens_hsa004801.07565779
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07367109
42Bladder cancer_Homo sapiens_hsa052191.06202992
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05388306
44Wnt signaling pathway_Homo sapiens_hsa043100.99593666
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98995671
46One carbon pool by folate_Homo sapiens_hsa006700.98426074
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97947773
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95207838
49Butanoate metabolism_Homo sapiens_hsa006500.92100627
50Ovarian steroidogenesis_Homo sapiens_hsa049130.91202059
51Steroid biosynthesis_Homo sapiens_hsa001000.91114513
52Nicotine addiction_Homo sapiens_hsa050330.86274544
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82145070
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79993233
55Linoleic acid metabolism_Homo sapiens_hsa005910.77709518
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73571381
57Metabolic pathways_Homo sapiens_hsa011000.72239215
58Pyruvate metabolism_Homo sapiens_hsa006200.70845298
59Tryptophan metabolism_Homo sapiens_hsa003800.70635090
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62419922
61Peroxisome_Homo sapiens_hsa041460.61594571
62Pancreatic secretion_Homo sapiens_hsa049720.60014650
63Phenylalanine metabolism_Homo sapiens_hsa003600.58931813
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.57355721
65Ether lipid metabolism_Homo sapiens_hsa005650.56066722
66Cardiac muscle contraction_Homo sapiens_hsa042600.53343264
67Sulfur relay system_Homo sapiens_hsa041220.53021060
68Glycerolipid metabolism_Homo sapiens_hsa005610.52580872
69Phototransduction_Homo sapiens_hsa047440.50640978
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47415336
71RNA polymerase_Homo sapiens_hsa030200.45918727
72Bile secretion_Homo sapiens_hsa049760.44661435
73Inositol phosphate metabolism_Homo sapiens_hsa005620.42731079
74GABAergic synapse_Homo sapiens_hsa047270.42207865
75Fat digestion and absorption_Homo sapiens_hsa049750.41811202
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40818211
77Chemical carcinogenesis_Homo sapiens_hsa052040.40347584
78Lysine degradation_Homo sapiens_hsa003100.39608122
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39507425
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39208214
81Vitamin digestion and absorption_Homo sapiens_hsa049770.38636490
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38327720
83Lysosome_Homo sapiens_hsa041420.37694675
84Gastric acid secretion_Homo sapiens_hsa049710.37393058
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37370105
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37167812
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36500244
88Morphine addiction_Homo sapiens_hsa050320.35589430
89beta-Alanine metabolism_Homo sapiens_hsa004100.32940600
90Taste transduction_Homo sapiens_hsa047420.32874564
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.31888901
92TGF-beta signaling pathway_Homo sapiens_hsa043500.30191467
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.29393959
94N-Glycan biosynthesis_Homo sapiens_hsa005100.29215523
95Olfactory transduction_Homo sapiens_hsa047400.28703565
96Calcium signaling pathway_Homo sapiens_hsa040200.28201270
97Regulation of autophagy_Homo sapiens_hsa041400.27400117
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26664709
99Pathways in cancer_Homo sapiens_hsa052000.26308579
100Circadian entrainment_Homo sapiens_hsa047130.24430753

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