CLEC14A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)7.55650938
2surfactant homeostasis (GO:0043129)7.14309887
3vascular endothelial growth factor signaling pathway (GO:0038084)6.72205364
4lymphangiogenesis (GO:0001946)6.68248875
5blood vessel maturation (GO:0001955)6.60206079
6positive regulation of vasculogenesis (GO:2001214)6.24591848
7regulation of endothelial cell differentiation (GO:0045601)6.21015414
8endothelium development (GO:0003158)5.93032716
9endothelial tube morphogenesis (GO:0061154)5.90963819
10morphogenesis of an endothelium (GO:0003159)5.90963819
11regulation of vasculogenesis (GO:2001212)5.82878136
12positive regulation of endothelial cell differentiation (GO:0045603)5.70886851
13chemical homeostasis within a tissue (GO:0048875)5.63525355
14retina vasculature morphogenesis in camera-type eye (GO:0061299)5.56744551
15cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.49517965
16angiogenesis involved in wound healing (GO:0060055)5.11920009
17endothelial cell differentiation (GO:0045446)4.78545277
18Notch signaling involved in heart development (GO:0061314)4.64799005
19basement membrane organization (GO:0071711)4.41643679
20negative regulation of adherens junction organization (GO:1903392)4.40165787
21negative regulation of focal adhesion assembly (GO:0051895)4.40165787
22negative regulation of cell junction assembly (GO:1901889)4.40165787
23endothelial cell morphogenesis (GO:0001886)4.38933590
24regulation of blood vessel endothelial cell migration (GO:0043535)4.32077196
25cell migration involved in sprouting angiogenesis (GO:0002042)4.25882801
26negative regulation of nitric-oxide synthase activity (GO:0051001)4.17437882
27blood vessel endothelial cell migration (GO:0043534)4.00224527
28negative regulation of endothelial cell proliferation (GO:0001937)3.91216500
29artery development (GO:0060840)3.89813934
30vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.88071152
31patterning of blood vessels (GO:0001569)3.87843619
32positive regulation of urine volume (GO:0035810)3.83274749
33vasculogenesis (GO:0001570)3.79276046
34regulation of establishment or maintenance of cell polarity (GO:0032878)3.79147842
35renal filtration (GO:0097205)3.78769682
36negative regulation of angiogenesis (GO:0016525)3.72511637
37glomerular filtration (GO:0003094)3.71580018
38sprouting angiogenesis (GO:0002040)3.68774218
39venous blood vessel morphogenesis (GO:0048845)3.65574005
40ventricular trabecula myocardium morphogenesis (GO:0003222)3.64034283
41heart trabecula morphogenesis (GO:0061384)3.63242050
42negative regulation of fibrinolysis (GO:0051918)3.63212900
43negative regulation of blood vessel morphogenesis (GO:2000181)3.57938077
44negative regulation of blood vessel endothelial cell migration (GO:0043537)3.56787972
45substrate-dependent cell migration (GO:0006929)3.52028965
46endothelial cell proliferation (GO:0001935)3.48501878
47wound healing, spreading of cells (GO:0044319)3.46171454
48embryonic heart tube development (GO:0035050)3.45196421
49heart trabecula formation (GO:0060347)3.41550067
50negative regulation of vasculature development (GO:1901343)3.40974312
51negative regulation of endothelial cell apoptotic process (GO:2000352)3.40479590
52nephron epithelium development (GO:0072009)3.39210141
53negative regulation of platelet activation (GO:0010544)3.37471026
54trabecula morphogenesis (GO:0061383)3.36206356
55blood vessel remodeling (GO:0001974)3.35813657
56ovulation from ovarian follicle (GO:0001542)3.30450284
57negative regulation of DNA biosynthetic process (GO:2000279)3.30233092
58neuron projection extension involved in neuron projection guidance (GO:1902284)3.25657986
59axon extension involved in axon guidance (GO:0048846)3.25657986
60neuron remodeling (GO:0016322)3.25201965
61endothelial cell chemotaxis (GO:0035767)3.22155372
62regulation of focal adhesion assembly (GO:0051893)3.16363948
63regulation of cell-substrate junction assembly (GO:0090109)3.16363948
64negative regulation of endothelial cell migration (GO:0010596)3.16120010
65cAMP biosynthetic process (GO:0006171)3.10459932
66regulation of adherens junction organization (GO:1903391)3.10133092
67regulation of phospholipid biosynthetic process (GO:0071071)3.09779103
68positive regulation of receptor recycling (GO:0001921)3.07886337
69lung vasculature development (GO:0060426)3.05804676
70positive regulation of cell junction assembly (GO:1901890)3.05471199
71positive regulation of focal adhesion assembly (GO:0051894)3.05471199
72cell adhesion mediated by integrin (GO:0033627)3.04317907
73negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.03982969
74positive regulation of odontogenesis (GO:0042482)3.03423663
75anatomical structure maturation (GO:0071695)3.01748282
76endothelial cell migration (GO:0043542)3.01029547
77mRNA transcription from RNA polymerase II promoter (GO:0042789)3.00920838
78regulation of epithelial cell migration (GO:0010632)2.99781401
79dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.99670204
80regulation of metalloenzyme activity (GO:0048552)2.99522042
81response to xenobiotic stimulus (GO:0009410)2.95763700
82regulation of fibrinolysis (GO:0051917)2.93453791
83positive regulation of epithelial cell migration (GO:0010634)2.92846415
84peptidyl-tyrosine autophosphorylation (GO:0038083)2.91242368
85coronary vasculature morphogenesis (GO:0060977)2.89918886
86wound healing, spreading of epidermal cells (GO:0035313)2.89267685
87transcytosis (GO:0045056)2.88853521
88positive regulation of endothelial cell proliferation (GO:0001938)2.88617983
89hyaluronan catabolic process (GO:0030214)2.88324935
90midgut development (GO:0007494)2.86859590
91endochondral ossification (GO:0001958)2.86564738
92replacement ossification (GO:0036075)2.86564738
93positive regulation of adherens junction organization (GO:1903393)2.84598856
94mesodermal cell differentiation (GO:0048333)2.83934843
95definitive hemopoiesis (GO:0060216)2.83844294
96protein localization to endosome (GO:0036010)2.83100707
97positive regulation of endothelial cell apoptotic process (GO:2000353)2.82140518
98regulation of endothelial cell proliferation (GO:0001936)2.82079266
99lung lobe morphogenesis (GO:0060463)2.80572624
100cellular response to nitric oxide (GO:0071732)2.80217554
101negative regulation of vascular permeability (GO:0043116)2.79956462
102respiratory tube development (GO:0030323)2.79055825
103regulation of endothelial cell migration (GO:0010594)2.77736257
104regulation of urine volume (GO:0035809)2.76910149
105substrate adhesion-dependent cell spreading (GO:0034446)2.76202927
106regulation of endothelial cell apoptotic process (GO:2000351)2.76125702
107bundle of His cell to Purkinje myocyte communication (GO:0086069)2.76060778
108regulation of glomerular filtration (GO:0003093)2.72408284
109regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.72230520
110membrane raft organization (GO:0031579)2.72209547
111positive regulation of lipid kinase activity (GO:0090218)2.71086483
112positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.70715157
113regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.70188665
114gland morphogenesis (GO:0022612)2.69479050
115negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.69185571
116hormone catabolic process (GO:0042447)2.68763647
117regulation of sarcomere organization (GO:0060297)2.68566529
118negative regulation of hemostasis (GO:1900047)2.67979449
119negative regulation of blood coagulation (GO:0030195)2.67979449
120regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.67751263
121negative regulation of Rho protein signal transduction (GO:0035024)2.66808150
122positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.66047199
123establishment of endothelial barrier (GO:0061028)2.65132221
124negative regulation of epithelial cell migration (GO:0010633)2.64702788
125positive regulation of hemostasis (GO:1900048)2.61776944
126positive regulation of blood coagulation (GO:0030194)2.61776944
127gap junction assembly (GO:0016264)2.61374072
128regulation of cholesterol storage (GO:0010885)2.60550031
129low-density lipoprotein particle clearance (GO:0034383)2.59719885
130adhesion of symbiont to host (GO:0044406)2.59679794
131regulation of complement activation (GO:0030449)2.58821383
132positive regulation of endothelial cell migration (GO:0010595)2.58566681
133regulation of protein activation cascade (GO:2000257)2.58119279
134regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.54485055
135exogenous drug catabolic process (GO:0042738)2.54036766
136blood vessel morphogenesis (GO:0048514)2.53784510
137protein kinase C signaling (GO:0070528)2.53498256
138angiogenesis (GO:0001525)2.52367083
139ganglion development (GO:0061548)2.52005606
140regulation of vascular permeability (GO:0043114)2.51671592
141complement activation, alternative pathway (GO:0006957)2.51035801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.37422697
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.26302028
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.09310293
4GATA1_22025678_ChIP-Seq_K562_Human3.73991803
5CLOCK_20551151_ChIP-Seq_293T_Human3.44842459
6GATA2_21666600_ChIP-Seq_HMVEC_Human3.43332995
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.88417828
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.82927958
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.78567826
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74522346
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.41205964
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39368049
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.23304527
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.16749135
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.04348619
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00031957
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.99888359
18* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.98652099
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91030033
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.90401884
21ELK3_25401928_ChIP-Seq_HUVEC_Human1.90346857
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89579157
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.81571998
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.77759178
25SALL4_18804426_ChIP-ChIP_XEN_Mouse1.72213543
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.71954346
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.66965859
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65383077
29* TBX20_22080862_ChIP-Seq_HEART_Mouse1.62573177
30* TBX20_22328084_ChIP-Seq_HEART_Mouse1.62573177
31BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56718240
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56385910
33CJUN_26792858_Chip-Seq_BT549_Human1.55203539
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54745870
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52208643
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50511516
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49949059
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.49289170
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47042700
40SOX2_20726797_ChIP-Seq_SW620_Human1.45160195
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43329613
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42803469
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41081876
44GATA1_19941826_ChIP-Seq_K562_Human1.39859890
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36941579
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35559060
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.34317311
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30304400
49CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29363851
50CDX2_20551321_ChIP-Seq_CACO-2_Human1.28450478
51ZNF263_19887448_ChIP-Seq_K562_Human1.24813866
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24566754
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23614271
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23339916
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21520906
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.20527166
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19904969
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17257105
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13721675
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12527203
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12161415
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12161415
63SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11807139
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11799331
65* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11573262
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.11272051
67FOXA2_19822575_ChIP-Seq_HepG2_Human1.10879335
68TCF4_18268006_ChIP-ChIP_LS174T_Human1.09542581
69* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09431307
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09349834
71SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08410471
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07759278
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06888244
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06040201
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05779943
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02898139
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02112686
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02112686
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01367673
80BCAT_22108803_ChIP-Seq_LS180_Human1.00329068
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00222410
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99379814
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98558634
84* AHR_22903824_ChIP-Seq_MCF-7_Human0.97745969
85RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97711857
86EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96927654
87RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96927654
88MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95980838
89* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95818363
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95662839
91* BRD4_25478319_ChIP-Seq_HGPS_Human0.94344481
92RACK7_27058665_Chip-Seq_MCF-7_Human0.93801449
93RNF2_27304074_Chip-Seq_ESCs_Mouse0.92675370
94SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91565401
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91497029
96SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90888940
97GATA2_19941826_ChIP-Seq_K562_Human0.89315164
98* EZH2_27294783_Chip-Seq_ESCs_Mouse0.89013055
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89005342
100NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88509874
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87686760
102KDM2B_26808549_Chip-Seq_K562_Human0.87522568
103FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87135728
104TP53_23651856_ChIP-Seq_MEFs_Mouse0.87019556
105LXR_22292898_ChIP-Seq_THP-1_Human0.86932463
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86227668
107SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86007462
108* GATA4_25053715_ChIP-Seq_YYC3_Human0.85577352
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85555141
110TP53_18474530_ChIP-ChIP_U2OS_Human0.85513591
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85362731
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85362731
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85362731
114ISL1_27105846_Chip-Seq_CPCs_Mouse0.85137569
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84871115
116WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84867896
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84551296
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84479474
119TP63_23658742_ChIP-Seq_EP156T_Human0.84374706
120SA1_22415368_ChIP-Seq_MEFs_Mouse0.83922953
121RUNX_20019798_ChIP-Seq_JUKART_Human0.82941084
122EZH2_27304074_Chip-Seq_ESCs_Mouse0.82389575
123RXR_22108803_ChIP-Seq_LS180_Human0.81493069
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81203062
125MYC_27129775_Chip-Seq_CORNEA_Mouse0.80434970
126TP53_20018659_ChIP-ChIP_R1E_Mouse0.79777717
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78192045
128DROSHA_22980978_ChIP-Seq_HELA_Human0.76736922
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.76540786
130* RING1B_27294783_Chip-Seq_ESCs_Mouse0.75746897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.86634084
2MP0001879_abnormal_lymphatic_vessel5.84253855
3MP0005167_abnormal_blood-brain_barrier4.46548108
4MP0004272_abnormal_basement_membrane4.34449226
5MP0005360_urolithiasis3.86939876
6MP0003191_abnormal_cellular_cholesterol3.37491097
7MP0003705_abnormal_hypodermis_morpholog3.17119252
8MP0002138_abnormal_hepatobiliary_system3.16919408
9MP0003724_increased_susceptibility_to3.09626974
10MP0003828_pulmonary_edema2.95801182
11MP0004782_abnormal_surfactant_physiolog2.26549215
12MP0003950_abnormal_plasma_membrane2.25557650
13MP0004084_abnormal_cardiac_muscle2.22702838
14MP0009780_abnormal_chondrocyte_physiolo2.20433955
15MP0001958_emphysema2.14108917
16MP0002332_abnormal_exercise_endurance2.10805570
17MP0006138_congestive_heart_failure2.06872494
18MP0006054_spinal_hemorrhage2.06273658
19MP0000767_abnormal_smooth_muscle2.02110288
20MP0008875_abnormal_xenobiotic_pharmacok1.97740002
21MP0002139_abnormal_hepatobiliary_system1.84721635
22MP0004145_abnormal_muscle_electrophysio1.77437066
23MP0005165_increased_susceptibility_to1.68409396
24MP0002933_joint_inflammation1.67644732
25MP0005595_abnormal_vascular_smooth1.62884028
26MP0003279_aneurysm1.54262743
27MP0005085_abnormal_gallbladder_physiolo1.52417319
28MP0002295_abnormal_pulmonary_circulatio1.50613838
29MP0008438_abnormal_cutaneous_collagen1.46883300
30MP0003566_abnormal_cell_adhesion1.46063970
31MP0000249_abnormal_blood_vessel1.45308631
32MP0004883_abnormal_blood_vessel1.39310274
33MP0000013_abnormal_adipose_tissue1.38226621
34MP0005385_cardiovascular_system_phenoty1.36266328
35MP0001544_abnormal_cardiovascular_syste1.36266328
36MP0005365_abnormal_bile_salt1.34690521
37MP0000343_altered_response_to1.34024478
38MP0005164_abnormal_response_to1.27749673
39MP0004036_abnormal_muscle_relaxation1.26289188
40MP0003252_abnormal_bile_duct1.23935157
41MP0000465_gastrointestinal_hemorrhage1.23361781
42MP0003868_abnormal_feces_composition1.22547944
43MP0010030_abnormal_orbit_morphology1.21862484
44MP0002128_abnormal_blood_circulation1.20933078
45MP0003300_gastrointestinal_ulcer1.20125781
46MP0002877_abnormal_melanocyte_morpholog1.17378060
47MP0004215_abnormal_myocardial_fiber1.16976010
48MP0004147_increased_porphyrin_level1.12671349
49MP0003045_fibrosis1.12671164
50MP0005388_respiratory_system_phenotype1.12060511
51MP0002133_abnormal_respiratory_system1.12060511
52MP0004233_abnormal_muscle_weight1.10924491
53MP0005670_abnormal_white_adipose1.10508766
54MP0002925_abnormal_cardiovascular_devel1.10294465
55MP0003091_abnormal_cell_migration1.08352100
56MP0001614_abnormal_blood_vessel1.06952498
57MP0010329_abnormal_lipoprotein_level1.06881525
58MP0000749_muscle_degeneration1.03867835
59MP0008775_abnormal_heart_ventricle1.02340334
60MP0005275_abnormal_skin_tensile1.01718888
61MP0000003_abnormal_adipose_tissue0.99033304
62MP0005330_cardiomyopathy0.95291712
63MP0004130_abnormal_muscle_cell0.94052145
64MP0009840_abnormal_foam_cell0.91905338
65MP0001849_ear_inflammation0.91762515
66MP0000230_abnormal_systemic_arterial0.91684604
67MP0010630_abnormal_cardiac_muscle0.90078483
68MP0002972_abnormal_cardiac_muscle0.89734159
69MP0002106_abnormal_muscle_physiology0.88422578
70MP0002127_abnormal_cardiovascular_syste0.87492005
71MP0003567_abnormal_fetal_cardiomyocyte0.86942753
72MP0003303_peritoneal_inflammation0.86761157
73MP0002108_abnormal_muscle_morphology0.86606322
74MP0009764_decreased_sensitivity_to0.86238085
75MP0004085_abnormal_heartbeat0.85063803
76MP0005084_abnormal_gallbladder_morpholo0.84744593
77MP0004484_altered_response_of0.82962916
78MP0000751_myopathy0.81857560
79MP0005023_abnormal_wound_healing0.81475498
80MP0008004_abnormal_stomach_pH0.80236384
81MP0001915_intracranial_hemorrhage0.79715316
82MP0000759_abnormal_skeletal_muscle0.78307625
83MP0005369_muscle_phenotype0.77651800
84MP0000266_abnormal_heart_morphology0.75521876
85MP0003646_muscle_fatigue0.74614269
86MP0004510_myositis0.74471248
87MP0005083_abnormal_biliary_tract0.74272909
88MP0005375_adipose_tissue_phenotype0.74171998
89MP0003075_altered_response_to0.73865257
90MP0009278_abnormal_bone_marrow0.71258299
91MP0001851_eye_inflammation0.69558585
92MP0009643_abnormal_urine_homeostasis0.69239551
93MP0000537_abnormal_urethra_morphology0.69131305
94MP0001175_abnormal_lung_morphology0.68813693
95MP0001542_abnormal_bone_strength0.68384885
96MP0005620_abnormal_muscle_contractility0.66015050
97MP0002168_other_aberrant_phenotype0.64350558
98MP0001784_abnormal_fluid_regulation0.64244272
99MP0005623_abnormal_meninges_morphology0.63876454
100MP0009697_abnormal_copulation0.61101640
101MP0001853_heart_inflammation0.59777701
102MP0000733_abnormal_muscle_development0.59768194
103MP0003941_abnormal_skin_development0.59695898
104MP0005187_abnormal_penis_morphology0.59231799
105MP0000747_muscle_weakness0.59191929
106MP0000609_abnormal_liver_physiology0.59124693
107MP0003943_abnormal_hepatobiliary_system0.58808906
108MP0003385_abnormal_body_wall0.58675314
109MP0003948_abnormal_gas_homeostasis0.58409161
110MP0005503_abnormal_tendon_morphology0.57076719
111MP0002118_abnormal_lipid_homeostasis0.56682719
112MP0005409_darkened_coat_color0.56637592
113MP0004087_abnormal_muscle_fiber0.56159431
114MP0003984_embryonic_growth_retardation0.55811062
115MP0002088_abnormal_embryonic_growth/wei0.54982020
116MP0001756_abnormal_urination0.54781679
117MP0000750_abnormal_muscle_regeneration0.54109365
118MP0005319_abnormal_enzyme/_coenzyme0.53694975
119MP0002896_abnormal_bone_mineralization0.53533005
120MP0008995_early_reproductive_senescence0.53237509
121MP0001533_abnormal_skeleton_physiology0.53081519
122MP0005058_abnormal_lysosome_morphology0.52990642
123MP0005332_abnormal_amino_acid0.52650694
124MP0003935_abnormal_craniofacial_develop0.50915794
125MP0005166_decreased_susceptibility_to0.50077318
126MP0000467_abnormal_esophagus_morphology0.50061831
127MP0000613_abnormal_salivary_gland0.49742643
128MP0005376_homeostasis/metabolism_phenot0.49439265
129MP0003638_abnormal_response/metabolism_0.48456090
130MP0010352_gastrointestinal_tract_polyps0.47420532
131MP0002086_abnormal_extraembryonic_tissu0.47015378

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)7.48595955
2Spontaneous hematomas (HP:0007420)6.80907915
3Hematochezia (HP:0002573)6.69139612
4Deep venous thrombosis (HP:0002625)5.62022596
5Esophageal varix (HP:0002040)5.33717226
6Cerebral hemorrhage (HP:0001342)4.74933085
7Abnormality of the nasal mucosa (HP:0000433)4.72756572
8Conjunctival telangiectasia (HP:0000524)4.69063748
9Wrist flexion contracture (HP:0001239)4.61319503
10Visceral angiomatosis (HP:0100761)4.15878174
11Nonimmune hydrops fetalis (HP:0001790)4.00857365
12Abnormality of the vasculature of the conjunctiva (HP:0008054)4.00733379
13Cerebral aneurysm (HP:0004944)3.92816767
14Growth hormone excess (HP:0000845)3.89584058
15Hemangiomatosis (HP:0007461)3.87591247
16Interstitial pulmonary disease (HP:0006530)3.72699475
17Spinal rigidity (HP:0003306)3.63318459
18Myotonia (HP:0002486)3.61146989
19Mucosal telangiectasiae (HP:0100579)3.52383776
20Lymphangioma (HP:0100764)3.46505168
21Difficulty running (HP:0009046)3.43190586
22Broad metatarsal (HP:0001783)3.43173932
23Abnormality of skeletal muscle fiber size (HP:0012084)3.40170785
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.15047166
25Muscle fiber inclusion bodies (HP:0100299)3.14583454
26Nemaline bodies (HP:0003798)3.14109573
27Cavernous hemangioma (HP:0001048)3.10456724
28Portal hypertension (HP:0001409)3.05458100
29Hemorrhage of the eye (HP:0011885)2.94723319
30Hyperactive renin-angiotensin system (HP:0000841)2.92148991
31Distal lower limb muscle weakness (HP:0009053)2.90166047
32Joint hemorrhage (HP:0005261)2.90086428
33Microcytic anemia (HP:0001935)2.89000524
34Camptodactyly of toe (HP:0001836)2.83724944
35Difficulty climbing stairs (HP:0003551)2.83479168
36Premature rupture of membranes (HP:0001788)2.83280503
37Pulmonary hypertension (HP:0002092)2.78464723
38Type 1 muscle fiber predominance (HP:0003803)2.76473357
39Reduced subcutaneous adipose tissue (HP:0003758)2.76388711
40Round ear (HP:0100830)2.75675104
41Abnormality of the intrinsic pathway (HP:0010989)2.73958228
42Asymmetric septal hypertrophy (HP:0001670)2.73300336
43Potter facies (HP:0002009)2.71400999
44Facial shape deformation (HP:0011334)2.71400999
45Abnormality of the hepatic vasculature (HP:0006707)2.70504517
46Complement deficiency (HP:0004431)2.67843633
47Overgrowth (HP:0001548)2.65546873
48Aneurysm (HP:0002617)2.62765427
49Stroke (HP:0001297)2.59862083
50Aortic aneurysm (HP:0004942)2.59705589
51Intrahepatic cholestasis (HP:0001406)2.57750031
52Chondrocalcinosis (HP:0000934)2.57472651
53Hip contracture (HP:0003273)2.50057086
54Protrusio acetabuli (HP:0003179)2.49771161
55Hypercholesterolemia (HP:0003124)2.47831047
56Pulmonary embolism (HP:0002204)2.47683091
57Hypoplasia of the iris (HP:0007676)2.46225604
58EMG: myopathic abnormalities (HP:0003458)2.44867334
59Centrally nucleated skeletal muscle fibers (HP:0003687)2.42579097
60Abnormality of Sharpey fibers (HP:0100685)2.39455797
61Right ventricular cardiomyopathy (HP:0011663)2.37174593
62Menorrhagia (HP:0000132)2.36053597
63Aortic valve stenosis (HP:0001650)2.31135804
64Increased connective tissue (HP:0009025)2.30632830
65Thrombophlebitis (HP:0004418)2.27303852
66Cardiovascular calcification (HP:0011915)2.25115718
67Distal arthrogryposis (HP:0005684)2.24744717
68Joint contractures involving the joints of the feet (HP:0100492)2.23476688
69Flexion contracture of toe (HP:0005830)2.23476688
70Acanthosis nigricans (HP:0000956)2.22912554
71Xanthomatosis (HP:0000991)2.21739798
72Striae distensae (HP:0001065)2.21692299
73Exercise-induced myalgia (HP:0003738)2.20209325
74Supraventricular arrhythmia (HP:0005115)2.20078203
75Pulmonary artery stenosis (HP:0004415)2.19599715
76Venous insufficiency (HP:0005293)2.18845340
77Bone cyst (HP:0012062)2.18325379
78Ventricular tachycardia (HP:0004756)2.18297478
79Vascular calcification (HP:0004934)2.14803860
80Vascular tortuosity (HP:0004948)2.12178374
81Limited hip movement (HP:0008800)2.11990384
82Distal lower limb amyotrophy (HP:0008944)2.11504501
83Long toe (HP:0010511)2.11275597
84Hyperlipoproteinemia (HP:0010980)2.11191413
85Porencephaly (HP:0002132)2.10344459
86Muscle fiber splitting (HP:0003555)2.09496138
87Hypoglycemic coma (HP:0001325)2.07965437
88Abnormality of the common coagulation pathway (HP:0010990)2.07957735
89Neonatal death (HP:0003811)2.07388994
90Amyloidosis (HP:0011034)2.06806172
91Cervical subluxation (HP:0003308)2.05828119
92Atrioventricular block (HP:0001678)2.05485362
93Adactyly (HP:0009776)2.03576711
94Arterial tortuosity (HP:0005116)2.03374278
95Glucose intolerance (HP:0000833)2.03093915
96Hyporeflexia of lower limbs (HP:0002600)2.02678762
97Exotropia (HP:0000577)2.02528074
98Atrial fibrillation (HP:0005110)2.02353226
99Aortic dissection (HP:0002647)2.02271660
100Abnormality of monocarboxylic acid metabolism (HP:0010996)2.02157352
101Venous abnormality (HP:0002624)2.01534373
102Sudden death (HP:0001699)2.01052507
103Ectopia lentis (HP:0001083)2.00809892
104Areflexia of lower limbs (HP:0002522)2.00731858
105Hydroureter (HP:0000072)2.00501763
106Short hallux (HP:0010109)1.95810125
107Broad face (HP:0000283)1.94433839
108Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93840443
109Short 4th metacarpal (HP:0010044)1.93840443
110Impaired platelet aggregation (HP:0003540)1.93291177
111Abnormal platelet function (HP:0011869)1.93291177
112Abnormal atrioventricular conduction (HP:0005150)1.91847820
113Wormian bones (HP:0002645)1.91812491
114Myocardial infarction (HP:0001658)1.91811133
115Prolonged partial thromboplastin time (HP:0003645)1.91793132
116Abnormality of the fetal cardiovascular system (HP:0010948)1.91494421
117Abnormal umbilical cord blood vessels (HP:0011403)1.91494421
118Single umbilical artery (HP:0001195)1.91494421
119Pigmentary retinal degeneration (HP:0001146)1.91403974
120Neck muscle weakness (HP:0000467)1.91228299
121Abnormality of aromatic amino acid family metabolism (HP:0004338)1.88968821
122Vertebral clefting (HP:0008428)1.88898117
123Hypoalphalipoproteinemia (HP:0003233)1.88212284
124Skull defect (HP:0001362)1.88142683
125Blue sclerae (HP:0000592)1.87449804
126Asymmetry of the thorax (HP:0001555)1.87074527
127Mitral valve prolapse (HP:0001634)1.86595956
128Abnormal vertebral ossification (HP:0100569)1.86307090
129Mitral stenosis (HP:0001718)1.85171604
130Increased variability in muscle fiber diameter (HP:0003557)1.84982078
131Joint stiffness (HP:0001387)1.84534268
132Mildly elevated creatine phosphokinase (HP:0008180)1.83326036
133Heart block (HP:0012722)1.82029170
134Chronic bronchitis (HP:0004469)1.81987488
135Large hands (HP:0001176)1.81690959
136High pitched voice (HP:0001620)1.81634232
137Disproportionate tall stature (HP:0001519)1.80150946
138Aplasia/Hypoplasia of the hallux (HP:0008362)1.79229368
139Hypotension (HP:0002615)1.78411256
140Abnormality of complement system (HP:0005339)1.77762395
141Nephritis (HP:0000123)1.76730506
142Cerebral palsy (HP:0100021)1.76457275
143Intestinal polyposis (HP:0200008)1.75754145
144Shallow orbits (HP:0000586)1.75182412
145Tetraparesis (HP:0002273)1.74183197
146Capillary hemangiomas (HP:0005306)1.73569710
147Hemiplegia (HP:0002301)1.72847540
148Absent hand (HP:0004050)1.72669530
149Lipoatrophy (HP:0100578)1.71949889
150Abnormal glucose tolerance (HP:0001952)1.70342014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.77534782
2TGFBR24.40174696
3TGFBR12.87031173
4EPHB22.27377297
5TIE111.1985131
6RIPK11.99463499
7ERN11.90085582
8PTK2B1.78246526
9EPHB11.77073185
10GRK11.73749156
11FGFR41.72674394
12FER1.54866502
13PTK61.50972418
14MYLK1.47034922
15TRIB31.31436617
16PAK41.23414424
17PDGFRA1.22451750
18MAP2K31.19142212
19PKN21.08382002
20LRRK21.03000100
21EPHA31.02333066
22TTN0.96178312
23FGFR20.95050510
24NTRK10.94197329
25CSK0.92893930
26MAP3K30.90769062
27DMPK0.88466425
28PRKG20.86822353
29FGFR30.85684171
30BCKDK0.85201667
31NEK90.83271737
32STK100.81264753
33PTK20.80735463
34TRPM70.79513255
35EEF2K0.78921176
36INSRR0.77944114
37LATS10.77562973
38BMPR1B0.72854857
39PRKD10.70119335
40MET0.64428364
41SIK10.62144366
42JAK10.61559094
43CDK80.61425916
44MAPK120.57670686
45PDK20.55914180
46MOS0.55854448
47TEC0.55272956
48PRKCH0.54215147
49AKT30.50861734
50TYK20.49930315
51MAP3K70.49351666
52PDGFRB0.49068649
53ARAF0.48012679
54RET0.47238382
55GSK3A0.46699161
56JAK20.46288617
57ITK0.45270997
58EGFR0.44757053
59MAP3K10.44553836
60MAPK150.44297061
61MST40.43941528
62ILK0.42373331
63TESK10.40872913
64IGF1R0.39606242
65SRC0.38818997
66PRKAA20.38552941
67LMTK20.38271267
68TBK10.37897322
69BCR0.35784800
70HCK0.34872729
71DAPK20.34765040
72PDPK10.34568863
73DDR20.33058304
74RPS6KA20.33054096
75MAPKAPK30.32621925
76PIK3CG0.31448996
77JAK30.31309650
78MAP3K110.31255824
79MAP3K130.30446801
80IRAK30.30236100
81CDK90.29734466
82CAMK40.29151556
83ROCK10.28680698
84PRKD30.27698449
85MAP2K10.26241539
86INSR0.26020303
87ZAP700.25879312
88LIMK10.25639900
89MARK30.25346920
90STK30.25149784
91GRK70.24296896
92FGFR10.23562589
93ABL10.23138528
94MAPK40.22737950
95MAPKAPK50.21725978
96CAMK1D0.21519113
97MAPK70.21141503
98PAK20.20956593
99LATS20.20522353
100MAP2K20.20340561
101FLT30.20237606
102CDK60.20224606
103NLK0.20218179
104PAK30.19852281
105PHKG20.18933644
106PHKG10.18933644
107ABL20.17406481
108MST1R0.16818392
109KIT0.16609187
110PRKCE0.16401837
111PRKD20.16307726
112FES0.16204155
113MARK20.15761176
114BTK0.15156133
115ROCK20.14695139
116GRK50.14546115
117MAP3K60.14388767
118OBSCN0.14376459
119DAPK30.13473892
120PIK3CA0.12966848
121MAP3K20.12149943
122EPHA20.11585304
123CDC42BPA0.10153147
124AKT20.10128571
125MTOR0.09665704
126LCK0.08559359
127ERBB40.07540016
128PRKAA10.07164554
129PAK60.07132857
130SCYL20.05431889
131FYN0.05149486

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.18121110
2Complement and coagulation cascades_Homo sapiens_hsa046103.01201503
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.62124497
4Nitrogen metabolism_Homo sapiens_hsa009102.53184191
5ECM-receptor interaction_Homo sapiens_hsa045122.45461814
6Arginine biosynthesis_Homo sapiens_hsa002202.29529476
7Caffeine metabolism_Homo sapiens_hsa002322.17560337
8Fatty acid degradation_Homo sapiens_hsa000712.16241375
9Focal adhesion_Homo sapiens_hsa045102.11396281
10Tryptophan metabolism_Homo sapiens_hsa003802.09084674
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.02564181
12PPAR signaling pathway_Homo sapiens_hsa033201.81825628
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74844123
14Bile secretion_Homo sapiens_hsa049761.71426236
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.68404830
16Adherens junction_Homo sapiens_hsa045201.66576470
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62487674
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60859872
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.57509319
20Propanoate metabolism_Homo sapiens_hsa006401.44272861
21Staphylococcus aureus infection_Homo sapiens_hsa051501.35802342
22Fatty acid metabolism_Homo sapiens_hsa012121.35017541
23Dilated cardiomyopathy_Homo sapiens_hsa054141.30634916
24Other glycan degradation_Homo sapiens_hsa005111.29331376
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28880101
26Rap1 signaling pathway_Homo sapiens_hsa040151.26893923
27Malaria_Homo sapiens_hsa051441.24843960
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24186194
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23967765
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19700824
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18125691
32Small cell lung cancer_Homo sapiens_hsa052221.17488034
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16890549
34Retinol metabolism_Homo sapiens_hsa008301.15745988
35Amoebiasis_Homo sapiens_hsa051461.15634395
36Histidine metabolism_Homo sapiens_hsa003401.13250805
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12620064
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11991068
39Chemical carcinogenesis_Homo sapiens_hsa052041.10647702
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10225837
41Platelet activation_Homo sapiens_hsa046111.08468404
42Proteoglycans in cancer_Homo sapiens_hsa052051.07529426
43Pancreatic cancer_Homo sapiens_hsa052121.04071350
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03961966
45beta-Alanine metabolism_Homo sapiens_hsa004101.03954996
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03609987
47Protein digestion and absorption_Homo sapiens_hsa049741.01597533
48Selenocompound metabolism_Homo sapiens_hsa004501.01402546
49Dorso-ventral axis formation_Homo sapiens_hsa043201.00011014
50Viral myocarditis_Homo sapiens_hsa054160.98658497
51PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96675243
52Insulin resistance_Homo sapiens_hsa049310.94114362
53Tight junction_Homo sapiens_hsa045300.93456325
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93164254
55Peroxisome_Homo sapiens_hsa041460.91140913
56Vitamin digestion and absorption_Homo sapiens_hsa049770.90982015
57ABC transporters_Homo sapiens_hsa020100.90948221
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.89856478
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86213534
60Butanoate metabolism_Homo sapiens_hsa006500.86022665
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85399503
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82462544
63Fat digestion and absorption_Homo sapiens_hsa049750.81985066
64African trypanosomiasis_Homo sapiens_hsa051430.81333096
65Renin secretion_Homo sapiens_hsa049240.78996004
66Chronic myeloid leukemia_Homo sapiens_hsa052200.78460467
67Ovarian steroidogenesis_Homo sapiens_hsa049130.78184011
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.78099929
69Axon guidance_Homo sapiens_hsa043600.76276872
70VEGF signaling pathway_Homo sapiens_hsa043700.75224961
71Phenylalanine metabolism_Homo sapiens_hsa003600.73272796
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.72695031
73TGF-beta signaling pathway_Homo sapiens_hsa043500.71902905
74Renin-angiotensin system_Homo sapiens_hsa046140.70156033
75Fatty acid elongation_Homo sapiens_hsa000620.69931489
76GnRH signaling pathway_Homo sapiens_hsa049120.69868993
77Oxytocin signaling pathway_Homo sapiens_hsa049210.69498746
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67585069
79Toxoplasmosis_Homo sapiens_hsa051450.66228543
80Notch signaling pathway_Homo sapiens_hsa043300.65644652
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65193231
82Sulfur relay system_Homo sapiens_hsa041220.63915111
83Renal cell carcinoma_Homo sapiens_hsa052110.63633327
84Estrogen signaling pathway_Homo sapiens_hsa049150.63222696
85cAMP signaling pathway_Homo sapiens_hsa040240.60290045
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59666048
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59347733
88Melanogenesis_Homo sapiens_hsa049160.57281191
89Ras signaling pathway_Homo sapiens_hsa040140.57059283
90Endocytosis_Homo sapiens_hsa041440.57036889
91Arginine and proline metabolism_Homo sapiens_hsa003300.56769226
92Tyrosine metabolism_Homo sapiens_hsa003500.54944419
93Pathways in cancer_Homo sapiens_hsa052000.54648638
94Rheumatoid arthritis_Homo sapiens_hsa053230.53747775
95Starch and sucrose metabolism_Homo sapiens_hsa005000.52671304
96Sulfur metabolism_Homo sapiens_hsa009200.50868660
97MAPK signaling pathway_Homo sapiens_hsa040100.50868426
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.50357877
99Prion diseases_Homo sapiens_hsa050200.49773498
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49609365
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49536473
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49001549
103Salmonella infection_Homo sapiens_hsa051320.48950539
104Pertussis_Homo sapiens_hsa051330.47160091
105Pyruvate metabolism_Homo sapiens_hsa006200.46791372
106MicroRNAs in cancer_Homo sapiens_hsa052060.46779094
107Lysine degradation_Homo sapiens_hsa003100.46396977
108Basal cell carcinoma_Homo sapiens_hsa052170.45753733
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44671462
110Calcium signaling pathway_Homo sapiens_hsa040200.44279357
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.43871101
112Serotonergic synapse_Homo sapiens_hsa047260.43691842
113Shigellosis_Homo sapiens_hsa051310.43598900
114Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42941233
115Gap junction_Homo sapiens_hsa045400.42921540
116Hippo signaling pathway_Homo sapiens_hsa043900.42075247
117Insulin signaling pathway_Homo sapiens_hsa049100.41750302
118AMPK signaling pathway_Homo sapiens_hsa041520.41125804
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40808313
120HIF-1 signaling pathway_Homo sapiens_hsa040660.40436182
121Glioma_Homo sapiens_hsa052140.40411872
122Glycerolipid metabolism_Homo sapiens_hsa005610.39253761
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.39166505
124Hepatitis C_Homo sapiens_hsa051600.38179720
125Carbon metabolism_Homo sapiens_hsa012000.37784836
126Gastric acid secretion_Homo sapiens_hsa049710.36879842
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36729606
128Lysosome_Homo sapiens_hsa041420.35346173
129Bladder cancer_Homo sapiens_hsa052190.35140258
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34810077
131TNF signaling pathway_Homo sapiens_hsa046680.34007696
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33317737
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33209679
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.33172646
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33110449
136Choline metabolism in cancer_Homo sapiens_hsa052310.32823078
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32329761

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