CLEC12B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)8.16339669
2regulation of meiosis I (GO:0060631)7.73812600
3sex differentiation (GO:0007548)7.31789402
4negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)6.92392913
5glomerular basement membrane development (GO:0032836)6.57375198
6male sex determination (GO:0030238)6.50701789
7male meiosis (GO:0007140)6.38281052
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.35404608
9positive regulation by organism of defense response of other organism involved in symbiotic interact6.35404608
10modulation by symbiont of host immune response (GO:0052553)6.35404608
11positive regulation by symbiont of host defense response (GO:0052509)6.35404608
12modulation by symbiont of host defense response (GO:0052031)6.35404608
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.35404608
14fusion of sperm to egg plasma membrane (GO:0007342)6.18604919
15oocyte development (GO:0048599)6.05925437
16positive regulation of gamma-delta T cell activation (GO:0046645)6.05393631
17response to peptidoglycan (GO:0032494)5.97018510
18regulation of female gonad development (GO:2000194)5.96412133
19neutrophil activation involved in immune response (GO:0002283)5.78772197
20metanephric mesenchyme development (GO:0072075)5.77743072
21negative regulation of cell killing (GO:0031342)5.71824082
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.71824082
23DNA methylation involved in gamete generation (GO:0043046)5.66048037
24response to nitrosative stress (GO:0051409)5.63295753
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.61051327
26synaptonemal complex assembly (GO:0007130)5.50308804
27regulation of gonadotropin secretion (GO:0032276)5.47327290
28detection of molecule of bacterial origin (GO:0032490)5.38275075
29synaptonemal complex organization (GO:0070193)5.34671010
30detection of other organism (GO:0098543)5.28260608
31macrophage activation involved in immune response (GO:0002281)5.27113733
32anatomical structure regression (GO:0060033)5.26627987
33kidney mesenchyme development (GO:0072074)5.00385343
34detection of bacterium (GO:0016045)4.89982405
35cellular extravasation (GO:0045123)4.89386799
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.88535671
37detection of external biotic stimulus (GO:0098581)4.83838802
38negative regulation of interleukin-12 production (GO:0032695)4.80442086
39relaxation of cardiac muscle (GO:0055119)4.80428178
40regulation of B cell receptor signaling pathway (GO:0050855)4.69472319
41microglial cell activation (GO:0001774)4.64459621
42antigen processing and presentation of endogenous antigen (GO:0019883)4.60118524
43plasma membrane fusion (GO:0045026)4.59611559
44glomerulus development (GO:0032835)4.54879955
45regulation of skeletal muscle contraction (GO:0014819)4.50896863
46leukocyte aggregation (GO:0070486)4.46473440
47ovulation cycle (GO:0042698)4.41842438
48response to host immune response (GO:0052572)4.38611531
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.38611531
50neutrophil activation (GO:0042119)4.37884758
51leukocyte migration involved in inflammatory response (GO:0002523)4.37652813
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.37226843
53detection of biotic stimulus (GO:0009595)4.36614950
54positive regulation of meiosis (GO:0045836)4.35127994
55negative regulation of calcium ion transmembrane transport (GO:1903170)4.33644530
56negative regulation of calcium ion transmembrane transporter activity (GO:1901020)4.33644530
57positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.32936638
58regulation of gamma-delta T cell activation (GO:0046643)4.32917642
59macroautophagy (GO:0016236)4.27573884
60negative regulation of cation channel activity (GO:2001258)4.23168804
61xenobiotic catabolic process (GO:0042178)4.21906131
62diaphragm development (GO:0060539)4.17097593
63respiratory burst (GO:0045730)4.17073432
64macrophage activation (GO:0042116)4.16041946
65poly(A)+ mRNA export from nucleus (GO:0016973)4.12981590
66regulation of interferon-beta biosynthetic process (GO:0045357)4.11858275
67negative regulation of lymphocyte mediated immunity (GO:0002707)4.07506009
68regulation of mast cell degranulation (GO:0043304)4.03584434
69positive regulation of reproductive process (GO:2000243)4.02832660
70response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.01161621
71response to host (GO:0075136)4.01161621
72response to host defenses (GO:0052200)4.01161621
73neutrophil mediated immunity (GO:0002446)4.01121169
74positive regulation of meiotic cell cycle (GO:0051446)3.97806781
75granulocyte activation (GO:0036230)3.97596717
76Leydig cell differentiation (GO:0033327)3.95124903
77myeloid cell activation involved in immune response (GO:0002275)3.93914908
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.90836960
79positive regulation of mast cell activation (GO:0033005)3.90706163
80immunoglobulin mediated immune response (GO:0016064)3.90458912
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.89921784
82negative regulation of meiosis (GO:0045835)3.88376660
83response to muramyl dipeptide (GO:0032495)3.83460400
84astrocyte development (GO:0014002)3.78925721
85negative regulation of T cell mediated immunity (GO:0002710)3.76543109
86regulation of mast cell activation involved in immune response (GO:0033006)3.74749852
87regulation of myeloid leukocyte mediated immunity (GO:0002886)3.74344160
88skeletal muscle organ development (GO:0060538)3.72137172
89regulation of mast cell activation (GO:0033003)3.66078531
90response to misfolded protein (GO:0051788)3.65833490
91positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.64624275
92positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.61840430
93atrioventricular valve morphogenesis (GO:0003181)3.60337026
94regulation of leukocyte degranulation (GO:0043300)3.58649768
95embryonic foregut morphogenesis (GO:0048617)3.58274466
96negative regulation of leukocyte mediated immunity (GO:0002704)3.56197396
97relaxation of muscle (GO:0090075)3.54903513
98regulation of gamma-delta T cell differentiation (GO:0045586)3.51091295
99antigen processing and presentation via MHC class Ib (GO:0002475)3.50069759
100meiotic nuclear division (GO:0007126)3.49017927
101apoptotic cell clearance (GO:0043277)3.47480564
102regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.46389964
103negative regulation of erythrocyte differentiation (GO:0045647)3.45092544
104myeloid leukocyte mediated immunity (GO:0002444)3.40029777
105metanephric epithelium development (GO:0072207)3.39315102
106negative regulation of macrophage differentiation (GO:0045650)3.39209081
107male meiosis I (GO:0007141)3.36015299
108positive regulation of mast cell degranulation (GO:0043306)3.35633719
109positive regulation of mast cell activation involved in immune response (GO:0033008)3.35633719
110regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.30849999
111male genitalia development (GO:0030539)3.29547771
112positive regulation of cellular amide metabolic process (GO:0034250)3.28231050
113negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.27834751
114leukocyte degranulation (GO:0043299)3.26156287
115defense response to protozoan (GO:0042832)3.25068999
116B cell receptor signaling pathway (GO:0050853)3.24845090
117production of molecular mediator involved in inflammatory response (GO:0002532)3.24645680
118gene silencing by RNA (GO:0031047)3.21904379
119lipopolysaccharide-mediated signaling pathway (GO:0031663)3.20487043
120regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.20054922
121response to interleukin-15 (GO:0070672)3.19930557
122positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.19195305
123Sertoli cell development (GO:0060009)3.15629218
124regulation of tolerance induction (GO:0002643)3.15532269
125positive regulation of B cell differentiation (GO:0045579)3.15275011
126glial cell proliferation (GO:0014009)3.15269126
127establishment of protein localization to Golgi (GO:0072600)3.14084476
128chromosome organization involved in meiosis (GO:0070192)3.13422497
129regulation of regulated secretory pathway (GO:1903305)3.13405197
130hemoglobin metabolic process (GO:0020027)3.12733011
131germ cell migration (GO:0008354)3.12298518
132negative regulation of metanephros development (GO:0072217)3.11834373
133positive regulation of toll-like receptor signaling pathway (GO:0034123)3.09654811
134germ cell development (GO:0007281)3.08916347
135regulation of B cell differentiation (GO:0045577)3.07630671
136B cell mediated immunity (GO:0019724)3.06792494
137regulation of T-helper 2 cell differentiation (GO:0045628)3.06791747
138neutrophil chemotaxis (GO:0030593)3.01979977
139regulation of cardioblast differentiation (GO:0051890)3.00445686
140fibroblast migration (GO:0010761)2.98757263
141regulation of nucleobase-containing compound transport (GO:0032239)2.98588511
142regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.97622918
143germinal center formation (GO:0002467)2.97224159
144receptor guanylyl cyclase signaling pathway (GO:0007168)2.97208431
145cellular response to gonadotropin stimulus (GO:0071371)2.96343259
146positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.95713322
147myeloid leukocyte activation (GO:0002274)2.94949057
148negative regulation of interleukin-6 production (GO:0032715)2.94600567
149neutrophil migration (GO:1990266)2.94233681
150adrenal gland development (GO:0030325)2.93346345
151regulation of dendritic cell antigen processing and presentation (GO:0002604)2.92673081
152positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.92293457
153response to protozoan (GO:0001562)2.92274079
154regulation of macrophage cytokine production (GO:0010935)2.91163612
155activated T cell proliferation (GO:0050798)2.88323619
156negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.84801225
157interferon-gamma-mediated signaling pathway (GO:0060333)2.84769145
158regulation of T cell tolerance induction (GO:0002664)2.84692196
159positive regulation of interferon-alpha production (GO:0032727)2.84253604
160female gamete generation (GO:0007292)2.83217599
161negative regulation of toll-like receptor signaling pathway (GO:0034122)2.82568653
162cellular response to type I interferon (GO:0071357)2.81673875
163type I interferon signaling pathway (GO:0060337)2.81673875
164mesenchymal to epithelial transition (GO:0060231)2.81516938
165positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.81479132
166regulation of interleukin-6 biosynthetic process (GO:0045408)2.81307444
167glucocorticoid receptor signaling pathway (GO:0042921)2.81047095
168histone H4-K5 acetylation (GO:0043981)2.79610826
169histone H4-K8 acetylation (GO:0043982)2.79610826
170response to type I interferon (GO:0034340)2.79550420
171cellular response to interleukin-15 (GO:0071350)2.79371467
172COPI coating of Golgi vesicle (GO:0048205)2.77058177
173Golgi transport vesicle coating (GO:0048200)2.77058177
174cellular process involved in reproduction in multicellular organism (GO:0022412)2.74460020
175protein localization to Golgi apparatus (GO:0034067)2.72645651
176muscle cell fate commitment (GO:0042693)2.71738464
177regulation of protein polyubiquitination (GO:1902914)2.71686872
178response to water (GO:0009415)2.70385438
179protein targeting to Golgi (GO:0000042)2.69819835
180epithelial cell differentiation involved in kidney development (GO:0035850)2.69009017
181oogenesis (GO:0048477)2.68474044
182spermatid development (GO:0007286)2.66617942
183regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.65277205
184positive regulation of macrophage cytokine production (GO:0060907)2.65191966
185androgen biosynthetic process (GO:0006702)2.64221385
186epithelial cell fate commitment (GO:0072148)2.62393716
187negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61659982
188cilium or flagellum-dependent cell motility (GO:0001539)2.60818373
189placenta blood vessel development (GO:0060674)2.59021798
190cellular response to thyroid hormone stimulus (GO:0097067)2.57792510
191reproductive system development (GO:0061458)2.55393950
192regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.55344642
193peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.55122171
194positive regulation of mesonephros development (GO:0061213)2.54304783
195N-terminal protein amino acid acetylation (GO:0006474)2.53283890
196ovulation cycle process (GO:0022602)2.49865837
197gonadal mesoderm development (GO:0007506)13.5029231
198positive regulation of male gonad development (GO:2000020)11.5541021
199regulation of male gonad development (GO:2000018)10.2269427
200sex determination (GO:0007530)10.1493522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human7.02704607
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.20407420
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.43972229
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.53383725
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.74244191
6CLOCK_20551151_ChIP-Seq_293T_Human3.60274370
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.54764244
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.41269841
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.37418097
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33536671
11GATA1_22025678_ChIP-Seq_K562_Human3.14509613
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.98222639
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.90774186
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90447132
15SPI1_23547873_ChIP-Seq_NB4_Human2.80106914
16SPI1_23127762_ChIP-Seq_K562_Human2.76554659
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.75223754
18VDR_24763502_ChIP-Seq_THP-1_Human2.74494910
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.70072726
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.70072726
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.70072726
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.68317219
23RUNX_20019798_ChIP-Seq_JUKART_Human2.65461452
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63909096
25VDR_21846776_ChIP-Seq_THP-1_Human2.56786304
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52394538
27SCL_19346495_ChIP-Seq_HPC-7_Human2.50553473
28IKZF1_21737484_ChIP-ChIP_HCT116_Human2.46360836
29ESR1_21235772_ChIP-Seq_MCF-7_Human2.42641859
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35269099
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32199120
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.28395663
33MYB_26560356_Chip-Seq_TH2_Human2.25283171
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.17648444
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.15026948
36RUNX1_22412390_ChIP-Seq_EML_Mouse2.14750646
37BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13548223
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10476889
39VDR_24787735_ChIP-Seq_THP-1_Human2.09803574
40STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09459584
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07112670
42MAF_26560356_Chip-Seq_TH1_Human2.05077095
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00081921
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.96937401
45MYB_26560356_Chip-Seq_TH1_Human1.96125517
46UTX_26944678_Chip-Seq_JUKART_Human1.94278884
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.91732168
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89215789
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89156843
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88385883
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.87606750
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.81944357
53IGF1R_20145208_ChIP-Seq_DFB_Human1.78245895
54BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77894442
55TCF7_22412390_ChIP-Seq_EML_Mouse1.73121482
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.72789342
57KDM2B_26808549_Chip-Seq_DND41_Human1.70915351
58MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69621831
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.67197742
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.67107868
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66273694
62BCAT_22108803_ChIP-Seq_LS180_Human1.65689199
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65023359
64GATA3_27048872_Chip-Seq_THYMUS_Human1.63849556
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60789505
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57194474
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57106747
68MYC_22102868_ChIP-Seq_BL_Human1.56575085
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54102440
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.51831291
71* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51426292
72MAF_26560356_Chip-Seq_TH2_Human1.51009785
73ZNF263_19887448_ChIP-Seq_K562_Human1.50453114
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.50094738
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.50037949
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48602897
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47396253
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46867063
79KDM2B_26808549_Chip-Seq_K562_Human1.42208866
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.40121446
81GATA3_26560356_Chip-Seq_TH2_Human1.39859740
82RNF2_27304074_Chip-Seq_NSC_Mouse1.39054038
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.38660333
84PU_27001747_Chip-Seq_BMDM_Mouse1.37521830
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37357684
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37130343
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32166721
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.31726703
89FOXA2_19822575_ChIP-Seq_HepG2_Human1.30180070
90TRIM28_21343339_ChIP-Seq_HEK293_Human1.29527668
91* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28412305
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27594357
93SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26796621
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26682989
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.25788739
96* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25276269
97STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24406223
98FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23944884
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22438147
100* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21725497
101CREB1_26743006_Chip-Seq_LNCaP_Human1.21359837
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20873624
103KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20504718
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20168118
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20025448
106SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19702086
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18741047
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18671930
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17355060
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17113259
111NCOR1_26117541_ChIP-Seq_K562_Human1.16488419
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.15107359
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.15096509
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14379978
115* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14233276
116TP53_22127205_ChIP-Seq_IMR90_Human1.13607416
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13571090
118PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11794942
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10902720
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10807445
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07468345
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07390626
123* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06772480
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04235279
125ERG_21242973_ChIP-ChIP_JURKAT_Human1.03448768
126TBX20_22080862_ChIP-Seq_HEART_Mouse1.03422494
127TBX20_22328084_ChIP-Seq_HEART_Mouse1.03422494
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03261976
129ISL1_27105846_Chip-Seq_CPCs_Mouse1.02702692
130GATA1_19941826_ChIP-Seq_K562_Human1.02146694
131CBX2_27304074_Chip-Seq_ESCs_Mouse1.02105754
132EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00396783
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00149345
134ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99492244
135GATA1_26923725_Chip-Seq_HPCs_Mouse0.98867633
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98758319
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98680101
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.98211976
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98113082
140ESR1_20079471_ChIP-ChIP_T-47D_Human0.97742894
141SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97403995
142FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97370224
143KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94580512
144PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94356145
145* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92517360
146AHR_22903824_ChIP-Seq_MCF-7_Human0.92373390
147SMAD3_21741376_ChIP-Seq_ESCs_Human0.92281161
148TP53_16413492_ChIP-PET_HCT116_Human0.92206383
149GATA2_21666600_ChIP-Seq_HMVEC_Human0.91592423
150HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91392796
151MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90980987
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.90419848
153KDM2B_26808549_Chip-Seq_JURKAT_Human0.90315383
154ELK3_25401928_ChIP-Seq_HUVEC_Human0.90283062
155SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89437940
156LXR_22292898_ChIP-Seq_THP-1_Human0.88945557
157MYC_27129775_Chip-Seq_CORNEA_Mouse0.88189482
158NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87811520
159ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87437101
160RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86778859
161* SPI1_20517297_ChIP-Seq_HL60_Human0.86074526
162BCL6_27268052_Chip-Seq_Bcells_Human0.84348492
163CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83026374
164GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82566633
165GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82544920
166DROSHA_22980978_ChIP-Seq_HELA_Human0.82461045
167CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82286714
168CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82126135
169RACK7_27058665_Chip-Seq_MCF-7_Human0.82082476
170OCT4_19829295_ChIP-Seq_ESCs_Human0.81875150
171GATA2_19941826_ChIP-Seq_K562_Human0.80370181
172RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80026401
173BCOR_27268052_Chip-Seq_Bcells_Human0.79306805
174RING1B_27294783_Chip-Seq_NPCs_Mouse0.79060690
175NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78952328
176CHD1_26751641_Chip-Seq_LNCaP_Human0.78575453
177PKCTHETA_26484144_Chip-Seq_BREAST_Human0.78568288
178TCF4_18268006_ChIP-ChIP_LS174T_Human0.78501487
179KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78113194
180STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77071541
181SMRT_27268052_Chip-Seq_Bcells_Human0.74043402
182STAT1_20625510_ChIP-Seq_HELA_Human0.71645746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence7.55890201
2MP0008877_abnormal_DNA_methylation6.11693021
3MP0003724_increased_susceptibility_to5.11987814
4MP0003878_abnormal_ear_physiology4.82972592
5MP0005377_hearing/vestibular/ear_phenot4.82972592
6MP0003283_abnormal_digestive_organ4.20624730
7MP0003436_decreased_susceptibility_to4.15169318
8MP0001835_abnormal_antigen_presentation3.88120994
9MP0003303_peritoneal_inflammation3.82904346
10MP0003195_calcinosis3.56890786
11MP0009278_abnormal_bone_marrow3.29581944
12MP0002419_abnormal_innate_immunity3.28499777
13MP0003786_premature_aging3.05830012
14MP0009785_altered_susceptibility_to2.90940540
15MP0005025_abnormal_response_to2.87140675
16MP0005410_abnormal_fertilization2.78943185
17MP0001800_abnormal_humoral_immune2.76435986
18MP0005671_abnormal_response_to2.72132303
19MP0005000_abnormal_immune_tolerance2.72046337
20MP0000569_abnormal_digit_pigmentation2.65880022
21MP0006082_CNS_inflammation2.61198685
22MP0000685_abnormal_immune_system2.59540851
23MP0002723_abnormal_immune_serum2.52693109
24MP0001790_abnormal_immune_system2.49736191
25MP0005387_immune_system_phenotype2.49736191
26MP0002452_abnormal_antigen_presenting2.47111468
27MP0002420_abnormal_adaptive_immunity2.45510711
28MP0005464_abnormal_platelet_physiology2.42963044
29MP0001819_abnormal_immune_cell2.42640124
30MP0005647_abnormal_sex_gland2.38051922
31MP0003879_abnormal_hair_cell2.34566298
32MP0002210_abnormal_sex_determination2.32417693
33MP0003828_pulmonary_edema2.30323028
34MP0002148_abnormal_hypersensitivity_rea2.28311006
35MP0001929_abnormal_gametogenesis2.22806787
36MP0003172_abnormal_lysosome_physiology2.20481644
37MP0003191_abnormal_cellular_cholesterol2.16364568
38MP0004272_abnormal_basement_membrane2.15761547
39MP0001533_abnormal_skeleton_physiology2.13032254
40MP0002132_abnormal_respiratory_system2.12185647
41MP0008004_abnormal_stomach_pH2.10763418
42MP0003045_fibrosis2.07152556
43MP0001145_abnormal_male_reproductive2.05493674
44MP0001661_extended_life_span2.03020968
45MP0009384_cardiac_valve_regurgitation1.89049451
46MP0002405_respiratory_system_inflammati1.85685139
47MP0001727_abnormal_embryo_implantation1.83075962
48MP0003698_abnormal_male_reproductive1.82793134
49MP0005058_abnormal_lysosome_morphology1.82777702
50MP0002398_abnormal_bone_marrow1.81504278
51MP0000716_abnormal_immune_system1.80693558
52MP0003763_abnormal_thymus_physiology1.79305329
53MP0005171_absent_coat_pigmentation1.78951291
54MP0001958_emphysema1.78631882
55MP0003115_abnormal_respiratory_system1.78049897
56MP0000465_gastrointestinal_hemorrhage1.75955871
57MP0002009_preneoplasia1.74799955
58MP0001845_abnormal_inflammatory_respons1.74232084
59MP0004147_increased_porphyrin_level1.71892996
60MP0000653_abnormal_sex_gland1.70641000
61MP0003183_abnormal_peptide_metabolism1.70450584
62MP0000751_myopathy1.69702792
63MP0010155_abnormal_intestine_physiology1.66722355
64MP0009764_decreased_sensitivity_to1.66117898
65MP0003315_abnormal_perineum_morphology1.64940945
66MP0003300_gastrointestinal_ulcer1.64446762
67MP0005167_abnormal_blood-brain_barrier1.60995796
68MP0004947_skin_inflammation1.58572620
69MP0000537_abnormal_urethra_morphology1.55036812
70MP0004084_abnormal_cardiac_muscle1.53818106
71MP0004381_abnormal_hair_follicle1.52668807
72MP0004883_abnormal_blood_vessel1.51353211
73MP0002722_abnormal_immune_system1.50198999
74MP0003936_abnormal_reproductive_system1.49903755
75MP0002396_abnormal_hematopoietic_system1.49246101
76MP0000689_abnormal_spleen_morphology1.48111799
77MP0002168_other_aberrant_phenotype1.45837403
78MP0003075_altered_response_to1.44998381
79MP0005397_hematopoietic_system_phenotyp1.44744926
80MP0001545_abnormal_hematopoietic_system1.44744926
81MP0000858_altered_metastatic_potential1.43260086
82MP0002160_abnormal_reproductive_system1.42044927
83MP0002998_abnormal_bone_remodeling1.41807357
84MP0002429_abnormal_blood_cell1.41544869
85MP0004036_abnormal_muscle_relaxation1.41223378
86MP0008469_abnormal_protein_level1.39042451
87MP0009780_abnormal_chondrocyte_physiolo1.37537855
88MP0005451_abnormal_body_composition1.34788891
89MP0004742_abnormal_vestibular_system1.33878408
90MP0005408_hypopigmentation1.32290818
91MP0000703_abnormal_thymus_morphology1.25538133
92MP0005164_abnormal_response_to1.25521238
93MP0005670_abnormal_white_adipose1.24831804
94MP0002277_abnormal_respiratory_mucosa1.23741099
95MP0009333_abnormal_splenocyte_physiolog1.20449229
96MP0005389_reproductive_system_phenotype1.20396916
97MP0005248_abnormal_Harderian_gland1.19539447
98MP0005623_abnormal_meninges_morphology1.19316440
99MP0004510_myositis1.19225632
100MP0008438_abnormal_cutaneous_collagen1.18053136
101MP0004145_abnormal_muscle_electrophysio1.17638702
102MP0002166_altered_tumor_susceptibility1.16693410
103MP0001919_abnormal_reproductive_system1.16382355
104MP0006138_congestive_heart_failure1.15700757
105MP0005166_decreased_susceptibility_to1.14916637
106MP0002102_abnormal_ear_morphology1.10480462
107MP0000343_altered_response_to1.10318768
108MP0000639_abnormal_adrenal_gland1.08127592
109MP0001853_heart_inflammation1.06334728
110MP0003943_abnormal_hepatobiliary_system1.05773208
111MP0000015_abnormal_ear_pigmentation1.05155059
112MP0009379_abnormal_foot_pigmentation1.00870397
113MP0002161_abnormal_fertility/fecundity0.97783465
114MP0003448_altered_tumor_morphology0.94933920
115MP0001440_abnormal_grooming_behavior0.92023300
116MP0003656_abnormal_erythrocyte_physiolo0.88914565
117MP0003279_aneurysm0.87343420
118MP0003942_abnormal_urinary_system0.86944985
119MP0005390_skeleton_phenotype0.85505039
120MP0009763_increased_sensitivity_to0.83778228
121MP0003122_maternal_imprinting0.83503388
122MP0002282_abnormal_trachea_morphology0.80845098
123MP0003091_abnormal_cell_migration0.80628412
124MP0001119_abnormal_female_reproductive0.79584512
125MP0003866_abnormal_defecation0.79567379
126MP0010386_abnormal_urinary_bladder0.77962191
127MP0001663_abnormal_digestive_system0.77612952
128MP0003123_paternal_imprinting0.77327400
129MP0003119_abnormal_digestive_system0.77325072
130MP0005075_abnormal_melanosome_morpholog0.75579656
131MP0005503_abnormal_tendon_morphology0.74684912
132MP0003806_abnormal_nucleotide_metabolis0.74608320
133MP0002139_abnormal_hepatobiliary_system0.73375383
134MP0000604_amyloidosis0.73296685
135MP0005174_abnormal_tail_pigmentation0.72931748
136MP0002006_tumorigenesis0.72545462
137MP0003252_abnormal_bile_duct0.72483276
138MP0001986_abnormal_taste_sensitivity0.70122320
139MP0001851_eye_inflammation0.69959399
140MP0009765_abnormal_xenobiotic_induced0.69418061
141MP0003795_abnormal_bone_structure0.69386198
142MP0003121_genomic_imprinting0.66913848
143MP0000249_abnormal_blood_vessel0.66012456
144MP0002332_abnormal_exercise_endurance0.64758081
145MP0002128_abnormal_blood_circulation0.64009453
146MP0008874_decreased_physiological_sensi0.62596515
147MP0004484_altered_response_of0.61802542
148MP0002653_abnormal_ependyma_morphology0.61425985
149MP0003690_abnormal_glial_cell0.61126052
150MP0002090_abnormal_vision0.60713552
151MP0000428_abnormal_craniofacial_morphol0.60627226
152MP0002896_abnormal_bone_mineralization0.59748795
153MP0000767_abnormal_smooth_muscle0.59322565
154MP0004130_abnormal_muscle_cell0.58679605
155MP0002254_reproductive_system_inflammat0.58652119
156MP0003329_amyloid_beta_deposits0.58518972
157MP0002295_abnormal_pulmonary_circulatio0.58375618
158MP0003221_abnormal_cardiomyocyte_apopto0.58134018
159MP0000013_abnormal_adipose_tissue0.56528180
160MP0004885_abnormal_endolymph0.55914121
161MP0003705_abnormal_hypodermis_morpholog0.55810131
162MP0002133_abnormal_respiratory_system0.54631096
163MP0005388_respiratory_system_phenotype0.54631096
164MP0004133_heterotaxia0.54581797
165MP0004808_abnormal_hematopoietic_stem0.54499737
166MP0002108_abnormal_muscle_morphology0.54177894
167MP0005395_other_phenotype0.53729382
168MP0005076_abnormal_cell_differentiation0.53384502
169MP0004197_abnormal_fetal_growth/weight/0.52775930
170MP0005376_homeostasis/metabolism_phenot0.50277160
171MP0000470_abnormal_stomach_morphology0.49490386
172MP0005319_abnormal_enzyme/_coenzyme0.48956640
173MP0000920_abnormal_myelination0.47849122
174MP0005310_abnormal_salivary_gland0.47233636
175MP0002938_white_spotting0.47081719
176MP0002933_joint_inflammation0.44530727
177MP0004043_abnormal_pH_regulation0.43585187
178MP0001784_abnormal_fluid_regulation0.43107177
179MP0002084_abnormal_developmental_patter0.42450650
180MP0008260_abnormal_autophagy0.41656356
181MP0003699_abnormal_female_reproductive0.40582626
182MP0000003_abnormal_adipose_tissue0.40254618
183MP0006054_spinal_hemorrhage0.40251810
184MP0003632_abnormal_nervous_system0.40118477

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)9.84282855
2Male infertility (HP:0003251)8.26320303
3Gonadotropin excess (HP:0000837)6.86154935
4Testicular neoplasm (HP:0010788)6.77002785
5Eczematoid dermatitis (HP:0000976)6.68097174
6Male pseudohermaphroditism (HP:0000037)6.67967531
7Recurrent bacterial skin infections (HP:0005406)6.39218993
8Recurrent abscess formation (HP:0002722)6.27630569
9Myositis (HP:0100614)5.78352570
10Abnormality of macrophages (HP:0004311)5.55833682
11Orchitis (HP:0100796)5.46142388
12Optic neuritis (HP:0100653)5.33746671
13Retrobulbar optic neuritis (HP:0100654)5.33746671
14Abnormal sex determination (HP:0012244)5.21727109
15Sex reversal (HP:0012245)5.21727109
16Recurrent gram-negative bacterial infections (HP:0005420)5.19991058
17Azoospermia (HP:0000027)4.99903383
18Stomatitis (HP:0010280)4.82416993
19Abnormality of male internal genitalia (HP:0000022)4.81651194
20Mesangial abnormality (HP:0001966)4.79891703
21Elevated erythrocyte sedimentation rate (HP:0003565)4.62242650
22Recurrent fungal infections (HP:0002841)4.36009920
23Recurrent skin infections (HP:0001581)4.29976541
24Germ cell neoplasia (HP:0100728)4.25278190
25Obstructive lung disease (HP:0006536)4.15384406
26Chronic obstructive pulmonary disease (HP:0006510)4.15384406
27Gastrointestinal infarctions (HP:0005244)4.14272977
28Infertility (HP:0000789)4.04111504
29Mediastinal lymphadenopathy (HP:0100721)4.04073308
30Hypoplastic left heart (HP:0004383)4.02664013
31Keratoconjunctivitis sicca (HP:0001097)3.95634306
32Recurrent cutaneous fungal infections (HP:0011370)3.94329956
33Chronic mucocutaneous candidiasis (HP:0002728)3.94329956
34Facial diplegia (HP:0001349)3.91388633
35Abnormal spermatogenesis (HP:0008669)3.86046480
36Meningitis (HP:0001287)3.81705885
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.78737810
38Prolonged bleeding time (HP:0003010)3.78500563
39Hand muscle atrophy (HP:0009130)3.71490145
40Follicular hyperkeratosis (HP:0007502)3.67387565
41Gingivitis (HP:0000230)3.63819117
42Encephalitis (HP:0002383)3.63032907
43Keratoconjunctivitis (HP:0001096)3.62627146
44Spontaneous hematomas (HP:0007420)3.59994893
4511 pairs of ribs (HP:0000878)3.56054879
46Stridor (HP:0010307)3.55366085
47Abnormal delayed hypersensitivity skin test (HP:0002963)3.53230916
48Hypoplasia of the uterus (HP:0000013)3.42112042
49Urticaria (HP:0001025)3.37015702
50Tongue fasciculations (HP:0001308)3.35926839
51Vasculitis (HP:0002633)3.33959783
52Ankle clonus (HP:0011448)3.32923892
53Amyloidosis (HP:0011034)3.30525373
54Hemoptysis (HP:0002105)3.29392381
55Diaphragmatic weakness (HP:0009113)3.27330556
56Gingival bleeding (HP:0000225)3.27275215
57Rectal prolapse (HP:0002035)3.23000207
58Hypoventilation (HP:0002791)3.18673110
59Arterial thrombosis (HP:0004420)3.15625151
60Increased IgE level (HP:0003212)3.13919502
61Chest pain (HP:0100749)3.13639747
62Epistaxis (HP:0000421)3.11809013
63Transposition of the great arteries (HP:0001669)3.09462105
64Abnormal connection of the cardiac segments (HP:0011545)3.09462105
65Abnormal ventriculo-arterial connection (HP:0011563)3.09462105
66Pulmonary artery stenosis (HP:0004415)3.09383834
67Muscle fibrillation (HP:0010546)3.06950279
68True hermaphroditism (HP:0010459)3.06071864
69Metaphyseal cupping (HP:0003021)3.05855664
70Episodic fever (HP:0001954)3.01482182
71Occipital encephalocele (HP:0002085)2.95903334
72Pulmonary infiltrates (HP:0002113)2.95203298
73Cellulitis (HP:0100658)2.92399220
74Upper limb amyotrophy (HP:0009129)2.91811688
75Distal upper limb amyotrophy (HP:0007149)2.91811688
76Hypoplastic heart (HP:0001961)2.90528169
77Leukocytosis (HP:0001974)2.88112070
78Peritonitis (HP:0002586)2.86058849
79Inflammation of the large intestine (HP:0002037)2.81221821
80Recurrent viral infections (HP:0004429)2.80874768
81T lymphocytopenia (HP:0005403)2.80806237
82Bladder diverticulum (HP:0000015)2.75065353
83Abnormality of T cell number (HP:0011839)2.72004301
84Clumsiness (HP:0002312)2.71861738
85Anomalous pulmonary venous return (HP:0010772)2.70683662
86Pulmonary embolism (HP:0002204)2.69209801
87Clonus (HP:0002169)2.67343959
88Anorexia (HP:0002039)2.67047204
89Petechiae (HP:0000967)2.66958419
90Gastrointestinal inflammation (HP:0004386)2.65090056
91Gangrene (HP:0100758)2.52476992
92Abnormality of the pulmonary veins (HP:0011718)2.51928012
93Long eyelashes (HP:0000527)2.51671330
94Ankle contracture (HP:0006466)2.51642121
95Colitis (HP:0002583)2.48701512
96Increased cerebral lipofuscin (HP:0011813)2.48507200
97Osteomyelitis (HP:0002754)2.46292768
98Abnormality of liposaccharide metabolism (HP:0010968)2.45058567
99Abnormality of glycosphingolipid metabolism (HP:0004343)2.45058567
100Abnormality of glycolipid metabolism (HP:0010969)2.45058567
101Stage 5 chronic kidney disease (HP:0003774)2.44323180
102Secondary amenorrhea (HP:0000869)2.43047080
103Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41719493
104Pustule (HP:0200039)2.35217125
105Granulocytopenia (HP:0001913)2.34338203
106Polycystic ovaries (HP:0000147)2.33704428
107Abnormality of T cells (HP:0002843)2.32376204
108Abnormality of the vocal cords (HP:0008777)2.31644035
109Increased neuronal autofluorescent lipopigment (HP:0002074)2.30372451
110Increased IgM level (HP:0003496)2.29714147
111Vertigo (HP:0002321)2.28758481
112Depressed nasal tip (HP:0000437)2.27891679
113Abnormality of the pleura (HP:0002103)2.27799805
114Abnormality of the aortic arch (HP:0012303)2.26932032
115Abnormality of the endocardium (HP:0004306)2.26027794
116Abnormal platelet volume (HP:0011876)2.25968896
117Purpura (HP:0000979)2.25605047
118Myopathic facies (HP:0002058)2.25277266
119Panhypogammaglobulinemia (HP:0003139)2.22382831
120Fasciculations (HP:0002380)2.21494240
121Primary amenorrhea (HP:0000786)2.21228100
122Hypochromic anemia (HP:0001931)2.18184776
123Protrusio acetabuli (HP:0003179)2.18014864
124Aplasia/hypoplasia of the uterus (HP:0008684)2.17053251
125Polyneuropathy (HP:0001271)2.16703406
126Missing ribs (HP:0000921)2.16561022
127Sepsis (HP:0100806)2.15965243
128Cheilitis (HP:0100825)2.15026092
129Abnormality of dentin (HP:0010299)2.14604568
130Absent/shortened dynein arms (HP:0200106)2.14084424
131Dynein arm defect of respiratory motile cilia (HP:0012255)2.14084424
132Nausea (HP:0002018)2.10766772
133Glomerulopathy (HP:0100820)2.10700278
134Abnormal respiratory motile cilium physiology (HP:0012261)2.09001305
135Hypochromic microcytic anemia (HP:0004840)2.08874821
136Alopecia of scalp (HP:0002293)2.05777512
137Hepatosplenomegaly (HP:0001433)2.05380328
138Eosinophilia (HP:0001880)2.03942516
139Skin ulcer (HP:0200042)2.02709069
140Increased serum ferritin (HP:0003281)2.01958027
141Lymphangioma (HP:0100764)1.99878828
142Acne (HP:0001061)1.98564037
143Dysostosis multiplex (HP:0000943)1.97319471
144Chronic bronchitis (HP:0004469)1.97240381
145Hypergammaglobulinemia (HP:0010702)1.96227119
146Abnormality of the peritoneum (HP:0002585)1.95257903
147Absent frontal sinuses (HP:0002688)1.94166984
148Abnormality of T cell physiology (HP:0011840)1.94110628
149Amaurosis fugax (HP:0100576)1.92904385
150Osteolytic defects of the phalanges of the hand (HP:0009771)1.92543645
151Osteolytic defects of the hand bones (HP:0009699)1.92543645
152Keratitis (HP:0000491)1.92280242
153Rhinitis (HP:0012384)1.91137232
154Viral hepatitis (HP:0006562)1.90717377
155Autoimmune thrombocytopenia (HP:0001973)1.89057215
156Skin rash (HP:0000988)1.88317464
157Loss of speech (HP:0002371)1.87714202
158Abnormality of iron homeostasis (HP:0011031)1.87177405
159Acute hepatic failure (HP:0006554)1.85799089
160Focal segmental glomerulosclerosis (HP:0000097)1.85554151
161Chronic otitis media (HP:0000389)1.84789455
162Abnormality of the lower motor neuron (HP:0002366)1.84690246
163Ventricular fibrillation (HP:0001663)1.84510222
164Recurrent pneumonia (HP:0006532)1.83381719
165Renovascular hypertension (HP:0100817)1.82715989
166Thrombophlebitis (HP:0004418)1.82415539
167Subacute progressive viral hepatitis (HP:0006572)1.80549319
168Premature loss of primary teeth (HP:0006323)1.80179869
169Microcytic anemia (HP:0001935)1.78268049
170Menorrhagia (HP:0000132)1.76336671
171Lymphopenia (HP:0001888)1.75717780
172Aplasia/Hypoplasia of the tibia (HP:0005772)1.74061140
173Hyperkalemia (HP:0002153)1.71666888
174Slow saccadic eye movements (HP:0000514)1.71380475
175Abnormality of the musculature of the hand (HP:0001421)1.70141299
176Arachnodactyly (HP:0001166)1.67825224
177Abnormality of oral frenula (HP:0000190)1.66484173
178Abnormality of chloride homeostasis (HP:0011422)1.64440511
179Inguinal hernia (HP:0000023)1.63980141
180Ovarian neoplasm (HP:0100615)1.61246898
181Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.59997845
182Abnormal respiratory epithelium morphology (HP:0012253)1.58728773
183Abnormal respiratory motile cilium morphology (HP:0005938)1.58728773
184Primary adrenal insufficiency (HP:0008207)1.58392076
185Truncal obesity (HP:0001956)1.57795829
186Hypoplasia of the iris (HP:0007676)1.57562469
187Mitral regurgitation (HP:0001653)1.57238471
188Pulmonary fibrosis (HP:0002206)1.56127085
189Childhood onset (HP:0011463)1.55806844
190Hypoplastic iliac wings (HP:0002866)1.54013853
191Spontaneous abortion (HP:0005268)1.53997078
192Aortic aneurysm (HP:0004942)1.53128795
193Abnormality of the columella (HP:0009929)1.52820481
194Short nail (HP:0001799)1.51932873
195Female pseudohermaphroditism (HP:0010458)1.51110562
196Bulbar palsy (HP:0001283)1.50962187
197Mitral stenosis (HP:0001718)1.50337147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK35.41160761
2RIPK45.13335812
3BRD44.62416210
4TYRO34.46184375
5BLK3.72579344
6CDK123.30522209
7PRKD33.26730769
8IRAK43.25182870
9MAP2K33.17642815
10TYK22.61671014
11PTK2B2.57646000
12TRIB32.49731494
13PRPF4B2.34261773
14WNK42.33956287
15CDK92.29940124
16ICK2.26264187
17PTK62.26186577
18RIPK12.22806652
19EPHB12.21381172
20ZAP702.14974271
21MARK32.11184929
22FGR2.08134806
23GRK62.00611228
24BTK1.91241672
25WNK11.87452846
26PRKD21.86130255
27MAP3K31.84575686
28MAP3K141.81984052
29TNK21.80772659
30FER1.78682510
31SYK1.76909459
32CAMK1D1.75436652
33HCK1.73878091
34LATS11.69005866
35JAK31.66791822
36NTRK31.66488768
37TXK1.65400839
38PRKCH1.59588734
39MAP3K131.57448412
40PKN21.51508937
41TAOK11.48161623
42CAMK1G1.45585358
43JAK21.43797710
44LYN1.41950253
45IRAK21.37606524
46BMPR21.36674006
47MAP3K101.36487728
48PINK11.35413448
49TAOK31.34422231
50MAP3K21.31441573
51PDK41.30802893
52PDK31.30802893
53MAPK151.27616861
54KIT1.27536830
55CSF1R1.26574202
56IRAK11.26516337
57JAK11.25144903
58YES11.24662538
59CDK71.23317565
60TEC1.23165294
61TBK11.22270785
62MATK1.20621246
63NEK21.13776140
64STK391.10539025
65TESK11.10269711
66ERN11.09775469
67DAPK21.07691840
68MAP3K61.07026309
69LCK1.05181426
70CHUK1.03798137
71MYLK1.01953498
72CSNK1A1L1.00015470
73SIK30.99110478
74ITK0.97836214
75PIK3CG0.93716133
76PDK10.92872744
77PDGFRA0.92871392
78KSR20.92809322
79IKBKB0.91350521
80MTOR0.90544663
81MARK20.88093364
82STK30.87548853
83PAK40.87329053
84CDK40.86013161
85PDPK10.85434105
86MAP3K40.83399947
87EEF2K0.81712190
88RET0.81486320
89LIMK10.79978769
90STK100.79761562
91TGFBR20.73491152
92CDK190.72418698
93GSK3A0.71874702
94TAOK20.71624071
95MKNK20.71205978
96MAPKAPK50.68725370
97MAPK120.68428958
98BMX0.64558449
99PTK20.62679637
100LRRK20.62676576
101MAP2K40.61799460
102LMTK20.61706216
103IKBKE0.60860375
104FYN0.59658808
105MAP3K10.58640417
106PRKCQ0.57256591
107MAPK70.56709102
108STK380.56488523
109MAP3K70.55975159
110CDK60.54988253
111STK110.54956082
112FGFR30.54489521
113PASK0.54487433
114MKNK10.53717008
115SGK20.52719303
116RAF10.52606256
117CSK0.52123000
118PDGFRB0.50168817
119HIPK20.50035440
120DYRK1B0.48302518
121DYRK30.47163192
122MAPK30.45765392
123CSNK1G30.45678255
124PAK20.45496047
125GRK70.44572961
126MOS0.44143762
127TTN0.44063161
128MAP3K110.43862150
129MAP2K20.43636581
130PAK30.43211236
131SIK20.42903415
132STK40.42618825
133RPS6KL10.42429186
134RPS6KC10.42429186
135PIM10.42124395
136MINK10.42117611
137PDK20.41237454
138MAP2K60.40426018
139CSNK1G10.40271241
140ATM0.39903402
141MAPK10.39869464
142ERBB20.39755498
143CDC42BPA0.39388349
144CAMKK20.38546707
145CDC70.38376040
146TNIK0.37912094
147RPS6KA60.36276560
148WEE10.35478024
149SGK4940.35231525
150SGK2230.35231525
151CSNK1G20.34352540
152MAP4K10.34179524
153SGK30.34059092
154MAPK80.32185173
155MAPKAPK20.31910127
156NLK0.31737250
157RPS6KA50.31605459
158SGK10.31495115
159NEK90.30351033
160MAP3K50.29917361
161MAPKAPK30.29685169
162EGFR0.29433852
163PRKACB0.29038188
164CAMK40.28762993
165DMPK0.28496104
166TESK20.28338879
167EPHA30.27829558
168ATR0.27386309
169PRKG20.27286283
170FES0.26981184
171KSR10.25522925
172ERBB30.25502055
173FGFR40.25401052
174PRKDC0.24626032

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.47822075
2Leishmaniasis_Homo sapiens_hsa051403.16167284
3Osteoclast differentiation_Homo sapiens_hsa043803.00177800
4Staphylococcus aureus infection_Homo sapiens_hsa051502.75183333
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50406735
6Fatty acid elongation_Homo sapiens_hsa000622.36594408
7Tuberculosis_Homo sapiens_hsa051522.29477771
8ECM-receptor interaction_Homo sapiens_hsa045122.27610729
9B cell receptor signaling pathway_Homo sapiens_hsa046622.24845734
10Vitamin digestion and absorption_Homo sapiens_hsa049772.23505734
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.20029368
12TGF-beta signaling pathway_Homo sapiens_hsa043502.13349614
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12502603
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.08959291
15Graft-versus-host disease_Homo sapiens_hsa053322.08813637
16Allograft rejection_Homo sapiens_hsa053301.99236948
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.98110464
18Ovarian steroidogenesis_Homo sapiens_hsa049131.95000484
19Fatty acid biosynthesis_Homo sapiens_hsa000611.92525004
20Malaria_Homo sapiens_hsa051441.87569443
21Notch signaling pathway_Homo sapiens_hsa043301.86877988
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83034874
23Axon guidance_Homo sapiens_hsa043601.82676301
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82642607
25Autoimmune thyroid disease_Homo sapiens_hsa053201.82249646
26Legionellosis_Homo sapiens_hsa051341.81883387
27Fatty acid metabolism_Homo sapiens_hsa012121.76165749
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.75888558
29Renin secretion_Homo sapiens_hsa049241.71922566
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.70704365
31Amoebiasis_Homo sapiens_hsa051461.68376799
32Hematopoietic cell lineage_Homo sapiens_hsa046401.65075978
33Chemokine signaling pathway_Homo sapiens_hsa040621.64728285
34Adherens junction_Homo sapiens_hsa045201.64269720
35Lysine degradation_Homo sapiens_hsa003101.61627732
36Measles_Homo sapiens_hsa051621.59089038
37T cell receptor signaling pathway_Homo sapiens_hsa046601.55504900
38Acute myeloid leukemia_Homo sapiens_hsa052211.54729141
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.52800247
40Small cell lung cancer_Homo sapiens_hsa052221.52288320
41Hedgehog signaling pathway_Homo sapiens_hsa043401.51900890
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.51892256
43Focal adhesion_Homo sapiens_hsa045101.47683981
44Type I diabetes mellitus_Homo sapiens_hsa049401.46328855
45Primary immunodeficiency_Homo sapiens_hsa053401.45315192
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43778774
47Protein digestion and absorption_Homo sapiens_hsa049741.42916274
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36628822
49Other glycan degradation_Homo sapiens_hsa005111.35620790
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35300960
51Glutathione metabolism_Homo sapiens_hsa004801.33304853
52TNF signaling pathway_Homo sapiens_hsa046681.30451207
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29851654
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29685677
55Asthma_Homo sapiens_hsa053101.28676039
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28530625
57Complement and coagulation cascades_Homo sapiens_hsa046101.26028101
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24923738
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.24883351
60Intestinal immune network for IgA production_Homo sapiens_hsa046721.22227300
61Toxoplasmosis_Homo sapiens_hsa051451.20671833
62Non-small cell lung cancer_Homo sapiens_hsa052231.17485521
63Apoptosis_Homo sapiens_hsa042101.16972003
64cAMP signaling pathway_Homo sapiens_hsa040241.14939266
65Vascular smooth muscle contraction_Homo sapiens_hsa042701.14841213
66Pyruvate metabolism_Homo sapiens_hsa006201.14411346
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14396707
68Pertussis_Homo sapiens_hsa051331.13610540
69Hepatitis B_Homo sapiens_hsa051611.13379347
70Chemical carcinogenesis_Homo sapiens_hsa052041.11858154
71PPAR signaling pathway_Homo sapiens_hsa033201.10863247
72Rheumatoid arthritis_Homo sapiens_hsa053231.10100718
73Glucagon signaling pathway_Homo sapiens_hsa049221.09433167
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08507319
75Mineral absorption_Homo sapiens_hsa049781.07049123
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05952812
77African trypanosomiasis_Homo sapiens_hsa051431.05792016
78Antigen processing and presentation_Homo sapiens_hsa046121.03057051
79Salmonella infection_Homo sapiens_hsa051321.01831534
80Tight junction_Homo sapiens_hsa045301.00336138
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.99388968
82Fatty acid degradation_Homo sapiens_hsa000710.99027879
83Estrogen signaling pathway_Homo sapiens_hsa049150.97756970
84Long-term potentiation_Homo sapiens_hsa047200.95720845
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94735330
86Shigellosis_Homo sapiens_hsa051310.93700139
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90452672
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88728645
89Hepatitis C_Homo sapiens_hsa051600.88497330
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87330949
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86531624
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86232361
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85336039
94Chronic myeloid leukemia_Homo sapiens_hsa052200.85250093
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.83911111
96Lysosome_Homo sapiens_hsa041420.83161824
97Prostate cancer_Homo sapiens_hsa052150.82573016
98Viral myocarditis_Homo sapiens_hsa054160.81882923
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81414863
100Gastric acid secretion_Homo sapiens_hsa049710.80729698
101N-Glycan biosynthesis_Homo sapiens_hsa005100.79547907
102Selenocompound metabolism_Homo sapiens_hsa004500.79300560
103Oocyte meiosis_Homo sapiens_hsa041140.79264364
104Cocaine addiction_Homo sapiens_hsa050300.78781839
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77183671
106Proteoglycans in cancer_Homo sapiens_hsa052050.77132067
107Prion diseases_Homo sapiens_hsa050200.76369014
108mRNA surveillance pathway_Homo sapiens_hsa030150.74948966
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74314143
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.73446296
111Influenza A_Homo sapiens_hsa051640.73335232
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72781226
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72751561
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.72077656
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.71161364
116GnRH signaling pathway_Homo sapiens_hsa049120.69365112
117Prolactin signaling pathway_Homo sapiens_hsa049170.68422353
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68344365
119FoxO signaling pathway_Homo sapiens_hsa040680.67381247
120Platelet activation_Homo sapiens_hsa046110.67378943
121Choline metabolism in cancer_Homo sapiens_hsa052310.66604015
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66502243
123Endocytosis_Homo sapiens_hsa041440.65886452
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.64688144
125Basal cell carcinoma_Homo sapiens_hsa052170.63498423
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.61110889
127Insulin resistance_Homo sapiens_hsa049310.60535059
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60422807
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59587054
130Hippo signaling pathway_Homo sapiens_hsa043900.59387681
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59376340
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58917475
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58575584
134Endometrial cancer_Homo sapiens_hsa052130.58060433
135VEGF signaling pathway_Homo sapiens_hsa043700.57787955
136Regulation of autophagy_Homo sapiens_hsa041400.56211641
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56162412
138Viral carcinogenesis_Homo sapiens_hsa052030.56140828
139Pathways in cancer_Homo sapiens_hsa052000.54974711
140Amphetamine addiction_Homo sapiens_hsa050310.54857191
141Type II diabetes mellitus_Homo sapiens_hsa049300.53867320
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53326224
143Gap junction_Homo sapiens_hsa045400.52643540
144Oxytocin signaling pathway_Homo sapiens_hsa049210.51992415
145Glioma_Homo sapiens_hsa052140.51487391
146HIF-1 signaling pathway_Homo sapiens_hsa040660.51216490
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50715009
148Renal cell carcinoma_Homo sapiens_hsa052110.50004418
149Thyroid hormone synthesis_Homo sapiens_hsa049180.49903057
150mTOR signaling pathway_Homo sapiens_hsa041500.48758810
151Melanogenesis_Homo sapiens_hsa049160.48734095
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48397075
153Epstein-Barr virus infection_Homo sapiens_hsa051690.48013945
154Inositol phosphate metabolism_Homo sapiens_hsa005620.47925717
155MAPK signaling pathway_Homo sapiens_hsa040100.47840932
156Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47736952
157Adipocytokine signaling pathway_Homo sapiens_hsa049200.47065915
158Histidine metabolism_Homo sapiens_hsa003400.46339743
159Insulin secretion_Homo sapiens_hsa049110.45895699
160Herpes simplex infection_Homo sapiens_hsa051680.45798394
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.45699895
162Wnt signaling pathway_Homo sapiens_hsa043100.45283334
163Rap1 signaling pathway_Homo sapiens_hsa040150.42503951
164Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41727057
165Phagosome_Homo sapiens_hsa041450.41395921
166ErbB signaling pathway_Homo sapiens_hsa040120.39480286
167HTLV-I infection_Homo sapiens_hsa051660.39074748
168MicroRNAs in cancer_Homo sapiens_hsa052060.38444808
169Sphingolipid signaling pathway_Homo sapiens_hsa040710.37846184
170Pancreatic cancer_Homo sapiens_hsa052120.37719592
171Retinol metabolism_Homo sapiens_hsa008300.37668225
172Systemic lupus erythematosus_Homo sapiens_hsa053220.37653160
173Cyanoamino acid metabolism_Homo sapiens_hsa004600.35951193

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