CLDN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)8.08265583
2surfactant homeostasis (GO:0043129)7.74256985
3endothelium development (GO:0003158)7.72380782
4morphogenesis of an endothelium (GO:0003159)7.48457408
5endothelial tube morphogenesis (GO:0061154)7.48457408
6lymphangiogenesis (GO:0001946)7.07076239
7blood vessel maturation (GO:0001955)6.98141316
8positive regulation of vasculogenesis (GO:2001214)6.91790003
9vascular endothelial growth factor signaling pathway (GO:0038084)6.80085964
10regulation of vasculogenesis (GO:2001212)6.36860548
11regulation of endothelial cell differentiation (GO:0045601)6.35479581
12cellular response to vascular endothelial growth factor stimulus (GO:0035924)6.11743202
13chemical homeostasis within a tissue (GO:0048875)6.03141854
14cranial nerve structural organization (GO:0021604)5.96887745
15positive regulation of endothelial cell differentiation (GO:0045603)5.92366024
16endothelial cell differentiation (GO:0045446)5.20793527
17retina vasculature morphogenesis in camera-type eye (GO:0061299)5.03952191
18peristalsis (GO:0030432)4.58076165
19endothelial cell morphogenesis (GO:0001886)4.46959604
20vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.42780304
21basement membrane organization (GO:0071711)4.42688368
22ovulation from ovarian follicle (GO:0001542)4.26796023
23cAMP biosynthetic process (GO:0006171)4.24779635
24glomerular visceral epithelial cell development (GO:0072015)4.09770905
25vasculogenesis (GO:0001570)4.08247113
26blood vessel endothelial cell migration (GO:0043534)4.07686169
27renal filtration (GO:0097205)4.04487339
28sprouting angiogenesis (GO:0002040)4.02082485
29negative regulation of vascular permeability (GO:0043116)3.97002028
30cell migration involved in sprouting angiogenesis (GO:0002042)3.93597743
31negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.92231164
32glomerular filtration (GO:0003094)3.87660101
33negative regulation of blood vessel endothelial cell migration (GO:0043537)3.86742658
34patterning of blood vessels (GO:0001569)3.84975653
35phasic smooth muscle contraction (GO:0014821)3.84837811
36regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.82928888
37glomerular epithelial cell development (GO:0072310)3.81915798
38peptidyl-tyrosine autophosphorylation (GO:0038083)3.81873130
39anatomical structure arrangement (GO:0048532)3.81628300
40negative regulation of endothelial cell apoptotic process (GO:2000352)3.76493860
41venous blood vessel morphogenesis (GO:0048845)3.66309140
42endothelial cell proliferation (GO:0001935)3.56585903
43artery development (GO:0060840)3.50989475
44negative regulation of platelet activation (GO:0010544)3.50520378
45blood vessel remodeling (GO:0001974)3.48865134
46lung vasculature development (GO:0060426)3.47978206
47endothelial cell chemotaxis (GO:0035767)3.45473834
48respiratory tube development (GO:0030323)3.40801069
49Notch signaling involved in heart development (GO:0061314)3.33334066
50heart trabecula formation (GO:0060347)3.31427053
51neuron projection extension involved in neuron projection guidance (GO:1902284)3.31104616
52axon extension involved in axon guidance (GO:0048846)3.31104616
53negative regulation of endothelial cell migration (GO:0010596)3.29020559
54blood coagulation, intrinsic pathway (GO:0007597)3.24049360
55regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.19949377
56negative regulation of Rho protein signal transduction (GO:0035024)3.19077515
57nephron epithelium development (GO:0072009)3.15596455
58glomerular basement membrane development (GO:0032836)3.12484145
59regulation of vascular permeability (GO:0043114)3.12388279
60SMAD protein complex assembly (GO:0007183)3.12012985
61positive regulation of urine volume (GO:0035810)3.10704604
62positive regulation of endothelial cell proliferation (GO:0001938)3.09368285
63regulation of endothelial cell migration (GO:0010594)3.09327933
64negative regulation of focal adhesion assembly (GO:0051895)3.08859985
65negative regulation of cell junction assembly (GO:1901889)3.08859985
66negative regulation of adherens junction organization (GO:1903392)3.08859985
67substrate-dependent cell migration (GO:0006929)3.08357554
68positive regulation of receptor recycling (GO:0001921)3.07805120
69regulation of blood vessel endothelial cell migration (GO:0043535)3.06016142
70mesodermal cell differentiation (GO:0048333)3.05945584
71negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.03859836
72endothelial cell migration (GO:0043542)3.03527164
73wound healing, spreading of epidermal cells (GO:0035313)3.00602459
74negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.00284647
75regulation of endothelial cell apoptotic process (GO:2000351)2.98794682
76positive regulation of endothelial cell migration (GO:0010595)2.93094681
77embryonic heart tube development (GO:0035050)2.93054500
78regulation of phospholipid biosynthetic process (GO:0071071)2.92187551
79positive regulation of focal adhesion assembly (GO:0051894)2.92095172
80positive regulation of cell junction assembly (GO:1901890)2.92095172
81definitive hemopoiesis (GO:0060216)2.91558486
82coronary vasculature morphogenesis (GO:0060977)2.90670246
83negative regulation of endothelial cell proliferation (GO:0001937)2.90305151
84regulation of synapse maturation (GO:0090128)2.89952621
85cyclic purine nucleotide metabolic process (GO:0052652)2.89193258
86angiogenesis involved in wound healing (GO:0060055)2.88009083
87cGMP biosynthetic process (GO:0006182)2.87202547
88protein kinase C signaling (GO:0070528)2.85725203
89phospholipid homeostasis (GO:0055091)2.85362331
90negative regulation of angiogenesis (GO:0016525)2.84433789
91adenosine receptor signaling pathway (GO:0001973)2.80539969
92triglyceride catabolic process (GO:0019433)2.78737958
93establishment of endothelial barrier (GO:0061028)2.78655654
94negative regulation of epithelial cell migration (GO:0010633)2.78124127
95cellular response to estradiol stimulus (GO:0071392)2.77740548
96cyclic nucleotide biosynthetic process (GO:0009190)2.77342442
97stress fiber assembly (GO:0043149)2.77295808
98regulation of endothelial cell proliferation (GO:0001936)2.76204039
99ganglion development (GO:0061548)2.76042157
100regulation of synapse structural plasticity (GO:0051823)2.73321168
101mRNA transcription from RNA polymerase II promoter (GO:0042789)2.73319220
102positive regulation of adherens junction organization (GO:1903393)2.73129085
103positive regulation of odontogenesis (GO:0042482)2.72948970
104ovulation (GO:0030728)2.72588986
105dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.71795288
106positive regulation of p38MAPK cascade (GO:1900745)2.70717159
107lung lobe morphogenesis (GO:0060463)2.70609774
108negative regulation of blood vessel morphogenesis (GO:2000181)2.70537101
109regulation of lipoprotein metabolic process (GO:0050746)2.69229090
110renal system development (GO:0072001)2.69183348
111semaphorin-plexin signaling pathway (GO:0071526)2.68340047
112regulation of p38MAPK cascade (GO:1900744)2.67399326
113angiogenesis (GO:0001525)2.62436492
114anatomical structure maturation (GO:0071695)2.62203311
115embryonic foregut morphogenesis (GO:0048617)2.61530087
116cellular response to nitric oxide (GO:0071732)2.61262207
117regulation of epithelial cell migration (GO:0010632)2.61259315
118negative regulation of glycoprotein biosynthetic process (GO:0010561)2.60944583
119negative regulation of nitric-oxide synthase activity (GO:0051001)2.60588959
120negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.58868480
121vasculature development (GO:0001944)2.56652401
122cell migration involved in heart development (GO:0060973)2.56625749
123polarized epithelial cell differentiation (GO:0030859)2.56504277
124cellular response to epinephrine stimulus (GO:0071872)2.56035533
125regulation of establishment or maintenance of cell polarity (GO:0032878)2.55259013
126type B pancreatic cell proliferation (GO:0044342)2.54884041
127negative regulation of vasculature development (GO:1901343)2.53257100
128facial nerve structural organization (GO:0021612)2.53043492
129regulation of glomerular filtration (GO:0003093)2.52187730
130adherens junction assembly (GO:0034333)2.51440265
131neutral lipid catabolic process (GO:0046461)2.49681655
132acylglycerol catabolic process (GO:0046464)2.49681655
133blood vessel morphogenesis (GO:0048514)2.49106281
134regulation of axon extension involved in axon guidance (GO:0048841)2.49067153
135synaptic vesicle maturation (GO:0016188)2.46155865
136regulation of integrin-mediated signaling pathway (GO:2001044)2.45123099
137cGMP metabolic process (GO:0046068)2.44062227
138positive regulation of protein kinase C signaling (GO:0090037)2.43410962
139regulation of urine volume (GO:0035809)2.40499115
140positive regulation of glomerulus development (GO:0090193)2.40042141
141gland morphogenesis (GO:0022612)2.37918201
142regulation of cell-substrate junction assembly (GO:0090109)2.36253468
143regulation of focal adhesion assembly (GO:0051893)2.36253468
144activation of protein kinase A activity (GO:0034199)2.35190464
145cGMP-mediated signaling (GO:0019934)2.35010921
146cardiac muscle cell proliferation (GO:0060038)2.34854155
147regulation of cellular extravasation (GO:0002691)2.33794160
148regulation of adherens junction organization (GO:1903391)2.33467046
149mRNA transcription (GO:0009299)2.29934054
150triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.28761971
151transcytosis (GO:0045056)2.27390856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.24198665
2* GATA2_21666600_ChIP-Seq_HMVEC_Human3.22072400
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.14691471
4* CLOCK_20551151_ChIP-Seq_293T_Human2.85815297
5EZH2_22144423_ChIP-Seq_EOC_Human2.66915999
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.63049839
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.51686823
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.44767464
9GATA1_22025678_ChIP-Seq_K562_Human2.32126540
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.30906874
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.30562645
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.23677903
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.19813193
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.13323720
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06228187
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05082948
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98126040
18EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.94295303
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86307075
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.84748401
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.78214471
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78103517
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78103517
24GATA1_19941826_ChIP-Seq_K562_Human1.76493695
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73715702
26* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72773591
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67332250
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67332250
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67332250
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.67019843
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66627529
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.65275207
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64460546
34ZNF263_19887448_ChIP-Seq_K562_Human1.63372088
35KDM2B_26808549_Chip-Seq_K562_Human1.63236089
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63133919
37* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60632242
38* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57756921
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.53905870
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53635888
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53418710
42TBX20_22080862_ChIP-Seq_HEART_Mouse1.50190737
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.50190737
44LXR_22292898_ChIP-Seq_THP-1_Human1.47221882
45* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42995995
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40382441
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37355109
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34330832
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32319874
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31414020
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31233696
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30874385
53DROSHA_22980978_ChIP-Seq_HELA_Human1.28493003
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.27333011
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.26811982
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25433463
57SOX2_20726797_ChIP-Seq_SW620_Human1.25426484
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.24542785
59CTCF_27219007_Chip-Seq_Bcells_Human1.23227165
60KDM2B_26808549_Chip-Seq_DND41_Human1.21330082
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20607833
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20083296
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19928174
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19872670
65LXR_22158963_ChIP-Seq_LIVER_Mouse1.19661523
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.19456782
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18653341
68RACK7_27058665_Chip-Seq_MCF-7_Human1.18396469
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18304566
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17860003
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16876321
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.16587585
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15610656
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14486015
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14235086
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13923021
77MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12212056
78CJUN_26792858_Chip-Seq_BT549_Human1.11101039
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.10760750
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09256130
81SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08873350
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07729320
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07552828
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07471802
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.07084302
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06707657
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06479537
88SCL_19346495_ChIP-Seq_HPC-7_Human1.06287137
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05448037
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04994709
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.04252948
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.03691913
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03110285
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.02739519
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.01244492
96GATA2_19941826_ChIP-Seq_K562_Human1.00124767
97* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99881031
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99263103
99NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99185420
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99169175
101RXR_22158963_ChIP-Seq_LIVER_Mouse0.98786582
102TCF4_18268006_ChIP-ChIP_LS174T_Human0.98530491
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98466126
104* RING1B_27294783_Chip-Seq_ESCs_Mouse0.98437690
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98135345
106RING1B_27294783_Chip-Seq_NPCs_Mouse0.97577930
107EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97426164
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97359338
109EZH2_27304074_Chip-Seq_ESCs_Mouse0.96722279
110LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96594652
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96301177
112SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95996532
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94660830
114FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94091797
115SPI1_23127762_ChIP-Seq_K562_Human0.93229127
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92865202
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92839293
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92387925
119PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92273596
120* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91919236
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91541938
122GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91329706
123TP53_23651856_ChIP-Seq_MEFs_Mouse0.91073617
124P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90685457
125AHR_22903824_ChIP-Seq_MCF-7_Human0.90465197
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87888503
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.87540291
128ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85569799
129SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84318569
130P68_20966046_ChIP-Seq_HELA_Human0.83856035
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82915945
132SA1_27219007_Chip-Seq_Bcells_Human0.81297126
133RARB_27405468_Chip-Seq_BRAIN_Mouse0.77515784
134SA1_22415368_ChIP-Seq_MEFs_Mouse0.77186702
135KLF4_19829295_ChIP-Seq_ESCs_Human0.75642900
136TCF7_22412390_ChIP-Seq_EML_Mouse0.72411293
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.72329774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system8.00946519
2MP0001879_abnormal_lymphatic_vessel6.85143357
3* MP0005167_abnormal_blood-brain_barrier6.51042043
4MP0004272_abnormal_basement_membrane4.41077256
5MP0003724_increased_susceptibility_to3.47628069
6MP0002138_abnormal_hepatobiliary_system2.87582316
7MP0003828_pulmonary_edema2.68272631
8MP0001958_emphysema2.62260553
9MP0004084_abnormal_cardiac_muscle2.55885143
10MP0000749_muscle_degeneration2.29623714
11MP0004782_abnormal_surfactant_physiolog2.26882648
12MP0000767_abnormal_smooth_muscle2.17456635
13MP0000013_abnormal_adipose_tissue2.10918737
14MP0000465_gastrointestinal_hemorrhage2.09703160
15MP0006138_congestive_heart_failure2.07378344
16MP0006054_spinal_hemorrhage2.00848274
17MP0002295_abnormal_pulmonary_circulatio1.87079479
18MP0005595_abnormal_vascular_smooth1.83893284
19* MP0000249_abnormal_blood_vessel1.78231703
20MP0004859_abnormal_synaptic_plasticity1.75662491
21MP0000343_altered_response_to1.72601317
22MP0003191_abnormal_cellular_cholesterol1.65900825
23MP0003279_aneurysm1.62098060
24MP0003705_abnormal_hypodermis_morpholog1.53288611
25MP0001905_abnormal_dopamine_level1.50360080
26MP0004036_abnormal_muscle_relaxation1.49361761
27MP0003303_peritoneal_inflammation1.47694853
28MP0005165_increased_susceptibility_to1.46022223
29MP0003122_maternal_imprinting1.44939232
30MP0003880_abnormal_central_pattern1.43033429
31MP0009278_abnormal_bone_marrow1.41111796
32MP0002128_abnormal_blood_circulation1.39581278
33MP0005623_abnormal_meninges_morphology1.39065852
34MP0005385_cardiovascular_system_phenoty1.38510337
35MP0001544_abnormal_cardiovascular_syste1.38510337
36MP0005164_abnormal_response_to1.37649380
37MP0003566_abnormal_cell_adhesion1.37429313
38MP0008775_abnormal_heart_ventricle1.37125183
39MP0001486_abnormal_startle_reflex1.36294582
40MP0002933_joint_inflammation1.33989890
41MP0005386_behavior/neurological_phenoty1.33418391
42MP0004924_abnormal_behavior1.33418391
43MP0002925_abnormal_cardiovascular_devel1.32758331
44MP0004883_abnormal_blood_vessel1.32517452
45MP0002127_abnormal_cardiovascular_syste1.29915807
46MP0004085_abnormal_heartbeat1.28244852
47MP0003011_delayed_dark_adaptation1.27912446
48MP0002332_abnormal_exercise_endurance1.27316202
49MP0001614_abnormal_blood_vessel1.26259200
50MP0004215_abnormal_myocardial_fiber1.26210612
51MP0005670_abnormal_white_adipose1.20899586
52MP0004130_abnormal_muscle_cell1.18301292
53MP0008004_abnormal_stomach_pH1.17013072
54MP0005464_abnormal_platelet_physiology1.15331395
55MP0004484_altered_response_of1.14881819
56MP0002733_abnormal_thermal_nociception1.14188701
57MP0000537_abnormal_urethra_morphology1.12135982
58MP0005388_respiratory_system_phenotype1.10237571
59MP0002133_abnormal_respiratory_system1.10237571
60MP0000230_abnormal_systemic_arterial1.09429683
61MP0008438_abnormal_cutaneous_collagen1.06184642
62MP0003300_gastrointestinal_ulcer1.05831047
63MP0004270_analgesia1.01789465
64MP0002972_abnormal_cardiac_muscle1.00301843
65MP0005535_abnormal_body_temperature0.99927024
66MP0003075_altered_response_to0.99252071
67MP0003868_abnormal_feces_composition0.97899055
68MP0005409_darkened_coat_color0.97704572
69MP0009697_abnormal_copulation0.97513263
70MP0004147_increased_porphyrin_level0.95044987
71MP0010630_abnormal_cardiac_muscle0.93989932
72MP0002971_abnormal_brown_adipose0.93050694
73MP0003091_abnormal_cell_migration0.92944946
74MP0001851_eye_inflammation0.92625970
75MP0004510_myositis0.91891721
76MP0001501_abnormal_sleep_pattern0.89889248
77MP0005330_cardiomyopathy0.88888723
78MP0000751_myopathy0.87420184
79MP0000003_abnormal_adipose_tissue0.84987674
80MP0003638_abnormal_response/metabolism_0.84000358
81MP0001784_abnormal_fluid_regulation0.83398890
82MP0003635_abnormal_synaptic_transmissio0.82912372
83MP0000266_abnormal_heart_morphology0.82868621
84MP0005058_abnormal_lysosome_morphology0.82421090
85MP0003948_abnormal_gas_homeostasis0.79946085
86MP0005620_abnormal_muscle_contractility0.79774504
87MP0008875_abnormal_xenobiotic_pharmacok0.78835369
88MP0005375_adipose_tissue_phenotype0.77771185
89MP0005084_abnormal_gallbladder_morpholo0.77345463
90MP0001915_intracranial_hemorrhage0.76504231
91MP0005187_abnormal_penis_morphology0.76326814
92MP0004885_abnormal_endolymph0.74107823
93MP0005666_abnormal_adipose_tissue0.73513639
94MP0001849_ear_inflammation0.73101583
95MP0000516_abnormal_urinary_system0.72276717
96MP0005367_renal/urinary_system_phenotyp0.72276717
97MP0003943_abnormal_hepatobiliary_system0.71177763
98* MP0003631_nervous_system_phenotype0.70598221
99MP0001175_abnormal_lung_morphology0.69321652
100MP0001533_abnormal_skeleton_physiology0.68845557
101MP0002254_reproductive_system_inflammat0.68439722
102MP0003879_abnormal_hair_cell0.67484060
103MP0005275_abnormal_skin_tensile0.67422853
104MP0003632_abnormal_nervous_system0.65831991
105MP0003385_abnormal_body_wall0.65314948
106MP0002272_abnormal_nervous_system0.64847205
107MP0009379_abnormal_foot_pigmentation0.64758378
108MP0002063_abnormal_learning/memory/cond0.64202611
109* MP0003633_abnormal_nervous_system0.63790349
110MP0000750_abnormal_muscle_regeneration0.63300485
111MP0003959_abnormal_lean_body0.63048950
112MP0009780_abnormal_chondrocyte_physiolo0.62969847
113MP0006276_abnormal_autonomic_nervous0.62473120
114MP0000534_abnormal_ureter_morphology0.62320061
115MP0002064_seizures0.60885985
116MP0003690_abnormal_glial_cell0.60651434
117MP0000759_abnormal_skeletal_muscle0.60436079
118MP0010329_abnormal_lipoprotein_level0.60357144
119MP0005397_hematopoietic_system_phenotyp0.60267741
120MP0001545_abnormal_hematopoietic_system0.60267741
121MP0005166_decreased_susceptibility_to0.60038396
122MP0009764_decreased_sensitivity_to0.58225111
123MP0003950_abnormal_plasma_membrane0.57515577
124MP0002638_abnormal_pupillary_reflex0.56963620
125MP0002106_abnormal_muscle_physiology0.55283753
126MP0005448_abnormal_energy_balance0.54739707
127MP0000747_muscle_weakness0.54164034
128MP0004808_abnormal_hematopoietic_stem0.53489993
129MP0004087_abnormal_muscle_fiber0.52930407
130MP0009643_abnormal_urine_homeostasis0.49930402
131MP0008995_early_reproductive_senescence0.47860247
132MP0005023_abnormal_wound_healing0.47646630
133MP0002086_abnormal_extraembryonic_tissu0.47593632
134MP0004858_abnormal_nervous_system0.47121214
135MP0008874_decreased_physiological_sensi0.46203407
136MP0002132_abnormal_respiratory_system0.44100035

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)8.22852717
2Spontaneous hematomas (HP:0007420)7.22737432
3Hematochezia (HP:0002573)6.93070496
4Nonprogressive disorder (HP:0003680)5.44090379
5Esophageal varix (HP:0002040)5.18902639
6Abnormality of the nasal mucosa (HP:0000433)5.17413692
7Cerebral hemorrhage (HP:0001342)5.03472744
8Broad metatarsal (HP:0001783)4.52338608
9Visceral angiomatosis (HP:0100761)4.34024293
10Conjunctival telangiectasia (HP:0000524)4.33802916
11Nonimmune hydrops fetalis (HP:0001790)4.09331092
12Hemangiomatosis (HP:0007461)4.02327073
13Interstitial pulmonary disease (HP:0006530)4.00130264
14Lymphangioma (HP:0100764)3.87408368
15Deep venous thrombosis (HP:0002625)3.64896418
16Abnormality of the vasculature of the conjunctiva (HP:0008054)3.60028275
17Cerebral aneurysm (HP:0004944)3.59309315
18Increased mean platelet volume (HP:0011877)3.36234228
19Mesangial abnormality (HP:0001966)3.33864816
20Cavernous hemangioma (HP:0001048)3.25728138
21Wrist flexion contracture (HP:0001239)3.11616957
22Annular pancreas (HP:0001734)3.08176666
23Abnormal platelet volume (HP:0011876)3.02898787
24Growth hormone excess (HP:0000845)3.01594626
25Portal hypertension (HP:0001409)3.01062934
26Adactyly (HP:0009776)2.96763712
27Aortic aneurysm (HP:0004942)2.94783843
28Pigmentary retinal degeneration (HP:0001146)2.92206257
29Myotonia (HP:0002486)2.89019750
30Hyperactive renin-angiotensin system (HP:0000841)2.85449272
31Increased variability in muscle fiber diameter (HP:0003557)2.67116938
32Abnormality of the hepatic vasculature (HP:0006707)2.66426939
33Pulmonary artery stenosis (HP:0004415)2.63401492
34Abnormality of the periventricular white matter (HP:0002518)2.61379260
35Epistaxis (HP:0000421)2.61237044
36Hyperlipoproteinemia (HP:0010980)2.58610003
37Myocardial infarction (HP:0001658)2.57077343
38Joint hemorrhage (HP:0005261)2.56462731
39Mucosal telangiectasiae (HP:0100579)2.56236202
40Absent hand (HP:0004050)2.52665839
41Abnormality of the intrinsic pathway (HP:0010989)2.51038058
42Purpura (HP:0000979)2.49249303
43Oligomenorrhea (HP:0000876)2.48662538
44Microcytic anemia (HP:0001935)2.47316899
45Hydroureter (HP:0000072)2.47089354
46Round ear (HP:0100830)2.43830216
47Difficulty running (HP:0009046)2.43595873
48Short hallux (HP:0010109)2.42989753
49Stroke (HP:0001297)2.42718318
50Aneurysm (HP:0002617)2.42599525
51Asymmetry of the thorax (HP:0001555)2.41725193
52Pulmonary hypertension (HP:0002092)2.41557861
53Vascular tortuosity (HP:0004948)2.40382801
54Abnormality of skeletal muscle fiber size (HP:0012084)2.39096705
55Ventricular tachycardia (HP:0004756)2.37233371
56Muscle fiber splitting (HP:0003555)2.36791426
57Hemiplegia (HP:0002301)2.36141343
58Venous insufficiency (HP:0005293)2.35185057
59Pulmonary embolism (HP:0002204)2.30875924
60Rapidly progressive (HP:0003678)2.30758543
61Abnormality of binocular vision (HP:0011514)2.29189458
62Diplopia (HP:0000651)2.29189458
63Aplasia/Hypoplasia of the hallux (HP:0008362)2.27843937
64Porencephaly (HP:0002132)2.27709335
65Protrusio acetabuli (HP:0003179)2.23257089
66Increased connective tissue (HP:0009025)2.22495547
67Venous abnormality (HP:0002624)2.21135008
68Abnormal platelet function (HP:0011869)2.19706945
69Impaired platelet aggregation (HP:0003540)2.19706945
70Mitral valve prolapse (HP:0001634)2.17917077
71Hypertriglyceridemia (HP:0002155)2.17051341
72Focal segmental glomerulosclerosis (HP:0000097)2.16521897
73Arterial tortuosity (HP:0005116)2.13484627
74Spinal rigidity (HP:0003306)2.10893577
75Abnormal eating behavior (HP:0100738)2.10780686
76Sudden death (HP:0001699)2.10396213
77Systemic lupus erythematosus (HP:0002725)2.07927131
78Aortic dissection (HP:0002647)2.06859618
79Abnormality of the pulmonary veins (HP:0011718)2.06718749
80Amyloidosis (HP:0011034)2.06306447
81Skull defect (HP:0001362)2.05911709
82Ankle clonus (HP:0011448)2.04686096
83Hypoplasia of the iris (HP:0007676)2.03532360
84Shallow orbits (HP:0000586)2.01801309
85Striae distensae (HP:0001065)2.00262028
86Distal lower limb muscle weakness (HP:0009053)1.98044751
87Exercise-induced myalgia (HP:0003738)1.97171373
88Acanthosis nigricans (HP:0000956)1.96760225
89Atrial fibrillation (HP:0005110)1.96572661
90Abnormality of the fetal cardiovascular system (HP:0010948)1.96171446
91Abnormal umbilical cord blood vessels (HP:0011403)1.96171446
92Single umbilical artery (HP:0001195)1.96171446
93Hemorrhage of the eye (HP:0011885)1.95674896
94Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94588396
95Supraventricular arrhythmia (HP:0005115)1.94524518
96Menorrhagia (HP:0000132)1.94156115
97Subacute progressive viral hepatitis (HP:0006572)1.93901407
98Neoplasm of the heart (HP:0100544)1.93623125
99Atrioventricular block (HP:0001678)1.93083814
100Enlarged penis (HP:0000040)1.92950247
101Abnormal atrioventricular conduction (HP:0005150)1.92370350
102Heart block (HP:0012722)1.91287128
103Facial diplegia (HP:0001349)1.90815691
104Bulbar palsy (HP:0001283)1.90481868
105Delayed CNS myelination (HP:0002188)1.90297064
106Glomerulosclerosis (HP:0000096)1.89779628
107Back pain (HP:0003418)1.89636205
108Esotropia (HP:0000565)1.88349775
109Aortic valve stenosis (HP:0001650)1.88006623
110Absent toe (HP:0010760)1.87698428
111Long toe (HP:0010511)1.87683157
112Facial shape deformation (HP:0011334)1.87279200
113Potter facies (HP:0002009)1.87279200
114Difficulty climbing stairs (HP:0003551)1.86466728
115Disproportionate tall stature (HP:0001519)1.85562174
116Nuclear cataract (HP:0100018)1.85066582
117Polar cataract (HP:0010696)1.84826281
118Intestinal polyposis (HP:0200008)1.84728114
119Congenital, generalized hypertrichosis (HP:0004540)1.84617733
120Hyporeflexia of lower limbs (HP:0002600)1.84131393
121Intestinal polyp (HP:0005266)1.83744654
122Absent eyebrow (HP:0002223)1.83656575
123Tetraparesis (HP:0002273)1.83146383
124Abnormality of the peritoneum (HP:0002585)1.83061995
125Fatigue (HP:0012378)1.82396259
126Distal lower limb amyotrophy (HP:0008944)1.81366528
127Prolonged bleeding time (HP:0003010)1.81276940
128Primary atrial arrhythmia (HP:0001692)1.80238901
129Right ventricular cardiomyopathy (HP:0011663)1.79868325
130Bundle branch block (HP:0011710)1.79736421
131Complement deficiency (HP:0004431)1.78873853
132Ventricular fibrillation (HP:0001663)1.76527160
133Supraventricular tachycardia (HP:0004755)1.76506840
134Testicular atrophy (HP:0000029)1.76254946
135Chondrocalcinosis (HP:0000934)1.76051567
136Type 1 muscle fiber predominance (HP:0003803)1.75976954
137Cardiovascular calcification (HP:0011915)1.75627332
138Intestinal atresia (HP:0011100)1.75405148
139Neonatal death (HP:0003811)1.75354802
140Obstructive sleep apnea (HP:0002870)1.74942623
141Bronchomalacia (HP:0002780)1.73960864
142Foot dorsiflexor weakness (HP:0009027)1.73909327
143Nephritis (HP:0000123)1.73762406
144Thrombophlebitis (HP:0004418)1.72319428
145Petechiae (HP:0000967)1.71969852
146Renal salt wasting (HP:0000127)1.71729128
147Bladder diverticulum (HP:0000015)1.71686507
148Hypotrichosis (HP:0001006)1.71193144
149Anomalous pulmonary venous return (HP:0010772)1.70187339
150Cervical subluxation (HP:0003308)1.70128602

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.75367337
2TGFBR24.05729580
3ADRBK23.17990246
4TGFBR12.69859791
5ERN12.29195362
6RIPK12.28203313
7BMPR1B2.17528778
8EPHB22.01495270
9TIE111.5173207
10PTK2B1.96791958
11TRIB31.81059035
12EPHA41.75734786
13CDK81.70392251
14PTK61.45728468
15NTRK31.44203241
16FER1.39335842
17PRKG21.33998810
18MYLK1.33846638
19PKN21.24473510
20PAK41.20488310
21MAPKAPK31.10894797
22MAP2K31.10154034
23PDGFRA1.05590604
24EPHB11.01875185
25LRRK20.91316863
26FGFR40.90570802
27LATS20.89579678
28PRKD10.88647217
29PRKD30.87343665
30MAPK120.82837737
31FES0.82119849
32TESK10.81844600
33MAP2K70.81752133
34DMPK0.78552526
35TYRO30.77869616
36CAMK1D0.76203503
37PTK20.74008397
38MAP3K40.72373511
39DAPK20.71678249
40CSK0.71350154
41FGFR20.70712211
42MAP3K110.68338993
43PRKCH0.67900186
44KIT0.67039895
45CAMK1G0.66081326
46ARAF0.64693206
47TNK20.63769813
48MAP2K40.62980649
49PDPK10.62806471
50MAP3K10.61794793
51ACVR1B0.61600239
52MAPK150.61483406
53PHKG10.58822633
54PHKG20.58822633
55MAP2K20.57364318
56PDK20.53295593
57TTN0.53084613
58RET0.52967196
59PRKD20.52098881
60BMX0.51579925
61KSR20.51130211
62PDGFRB0.50357899
63PAK20.50247373
64ILK0.48158682
65GSK3A0.47444910
66MAP3K60.47301336
67EGFR0.44853908
68SRC0.43109117
69MET0.42239139
70CAMKK20.42058075
71MAP2K10.41847045
72JAK20.40889413
73MARK10.39878573
74PRKAA20.38171569
75MARK20.38171189
76MAP3K30.37819397
77DDR20.37690235
78MOS0.37608454
79IGF1R0.37195434
80CAMKK10.36822067
81ZAP700.36739070
82CAMK40.36194125
83AKT30.35752554
84PLK20.35747772
85LMTK20.35390803
86PKN10.34259432
87MAP4K10.33929130
88GRK50.33487679
89MAPK70.33046424
90FGFR30.32814092
91RIPK40.31388425
92TEC0.31145302
93MAP3K20.28949200
94MAP3K70.27891820
95HCK0.27701641
96JAK10.27010481
97PDK10.26817919
98NTRK20.26005075
99TBK10.25740305
100CAMK10.25277307
101MAPK40.24959140
102NTRK10.24804847
103ROCK10.24710283
104RPS6KA20.24223188
105PRKCE0.23892415
106ABL20.23344831
107MATK0.22481583
108OBSCN0.22209691
109FGR0.22074176
110PAK60.21849881
111ROCK20.21608094
112BCKDK0.20378069
113SGK4940.20193397
114SGK2230.20193397
115EPHA30.19756262
116ERBB20.19446609
117BTK0.19042593
118JAK30.19001896
119TRPM70.18878242
120EEF2K0.18397801
121CAMK2G0.18003515
122INSR0.17758788
123MAPK100.17752971
124MUSK0.17037135
125LIMK10.16394330
126DAPK30.16307336
127STK38L0.14740449
128PRKACG0.14591728
129STK100.14340050
130CSNK1G10.14334056
131MARK30.13320008
132SIK10.12920996
133CDK50.12773869
134CDK90.12378910
135FYN0.11612786
136ITK0.11003812
137CSNK1G20.10236541
138CSNK1G30.09975238

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.53637887
2Focal adhesion_Homo sapiens_hsa045102.21842803
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.15662534
4AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.98881414
5Platelet activation_Homo sapiens_hsa046111.80856122
6Nitrogen metabolism_Homo sapiens_hsa009101.80703538
7Rap1 signaling pathway_Homo sapiens_hsa040151.80372433
8Complement and coagulation cascades_Homo sapiens_hsa046101.76705309
9* Leukocyte transendothelial migration_Homo sapiens_hsa046701.73564182
10Renin secretion_Homo sapiens_hsa049241.68858707
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66909201
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65962060
13Dilated cardiomyopathy_Homo sapiens_hsa054141.65690834
14VEGF signaling pathway_Homo sapiens_hsa043701.54770274
15Axon guidance_Homo sapiens_hsa043601.52748596
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.51497692
17Other glycan degradation_Homo sapiens_hsa005111.49113311
18Adherens junction_Homo sapiens_hsa045201.47787458
19Gap junction_Homo sapiens_hsa045401.42666426
20* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39538850
21Bile secretion_Homo sapiens_hsa049761.38725638
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35076555
23Dorso-ventral axis formation_Homo sapiens_hsa043201.33996908
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33537805
25Synaptic vesicle cycle_Homo sapiens_hsa047211.33383637
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25552986
27PPAR signaling pathway_Homo sapiens_hsa033201.23930765
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20612791
29Amoebiasis_Homo sapiens_hsa051461.20024674
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19730649
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.18706122
32Salivary secretion_Homo sapiens_hsa049701.17306286
33Arginine biosynthesis_Homo sapiens_hsa002201.16004743
34Sulfur relay system_Homo sapiens_hsa041221.14656483
35Renal cell carcinoma_Homo sapiens_hsa052111.14116422
36Ovarian steroidogenesis_Homo sapiens_hsa049131.12666985
37Estrogen signaling pathway_Homo sapiens_hsa049151.12601639
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.12544697
39Notch signaling pathway_Homo sapiens_hsa043301.09897850
40Malaria_Homo sapiens_hsa051441.09471615
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09124264
42Proteoglycans in cancer_Homo sapiens_hsa052051.07811990
43Gastric acid secretion_Homo sapiens_hsa049711.07608240
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05969403
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05824992
46Small cell lung cancer_Homo sapiens_hsa052221.05101896
47* Tight junction_Homo sapiens_hsa045301.04573937
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03361398
49Long-term potentiation_Homo sapiens_hsa047201.00317510
50Oxytocin signaling pathway_Homo sapiens_hsa049210.98816768
51Caffeine metabolism_Homo sapiens_hsa002320.98103490
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97848221
53Serotonergic synapse_Homo sapiens_hsa047260.95317865
54Endocytosis_Homo sapiens_hsa041440.95154241
55Ras signaling pathway_Homo sapiens_hsa040140.94841694
56Protein digestion and absorption_Homo sapiens_hsa049740.94822435
57Histidine metabolism_Homo sapiens_hsa003400.92721040
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89770017
59Prion diseases_Homo sapiens_hsa050200.89667119
60African trypanosomiasis_Homo sapiens_hsa051430.88264260
61Salmonella infection_Homo sapiens_hsa051320.87991210
62Melanogenesis_Homo sapiens_hsa049160.85613636
63Circadian entrainment_Homo sapiens_hsa047130.84984342
64Dopaminergic synapse_Homo sapiens_hsa047280.84263092
65Arginine and proline metabolism_Homo sapiens_hsa003300.82795529
66GnRH signaling pathway_Homo sapiens_hsa049120.82716691
67Fatty acid degradation_Homo sapiens_hsa000710.82022668
68TGF-beta signaling pathway_Homo sapiens_hsa043500.81463197
69cAMP signaling pathway_Homo sapiens_hsa040240.81427752
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79808567
71Insulin resistance_Homo sapiens_hsa049310.79045148
72Renin-angiotensin system_Homo sapiens_hsa046140.78266822
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.77400415
74Cholinergic synapse_Homo sapiens_hsa047250.77300007
75Pathways in cancer_Homo sapiens_hsa052000.76547506
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.74851248
77Morphine addiction_Homo sapiens_hsa050320.74162080
78HIF-1 signaling pathway_Homo sapiens_hsa040660.73661976
79Staphylococcus aureus infection_Homo sapiens_hsa051500.72840754
80Insulin secretion_Homo sapiens_hsa049110.72350293
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71596485
82Pertussis_Homo sapiens_hsa051330.71444376
83Fat digestion and absorption_Homo sapiens_hsa049750.70889171
84Hippo signaling pathway_Homo sapiens_hsa043900.68951651
85Thyroid hormone synthesis_Homo sapiens_hsa049180.68890825
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68319061
87Toxoplasmosis_Homo sapiens_hsa051450.66727459
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.66533819
89Taste transduction_Homo sapiens_hsa047420.65271273
90Amphetamine addiction_Homo sapiens_hsa050310.64095005
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62859535
92Calcium signaling pathway_Homo sapiens_hsa040200.62271245
93Rheumatoid arthritis_Homo sapiens_hsa053230.61928793
94Choline metabolism in cancer_Homo sapiens_hsa052310.60098146
95Fatty acid metabolism_Homo sapiens_hsa012120.59127753
96Long-term depression_Homo sapiens_hsa047300.58377804
97Insulin signaling pathway_Homo sapiens_hsa049100.57692796
98Collecting duct acid secretion_Homo sapiens_hsa049660.57384076
99AMPK signaling pathway_Homo sapiens_hsa041520.57340741
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.56939977
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56621050
102ABC transporters_Homo sapiens_hsa020100.56003825
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55505850
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.54750011
105Type II diabetes mellitus_Homo sapiens_hsa049300.54509585
106Phenylalanine metabolism_Homo sapiens_hsa003600.54448376
107GABAergic synapse_Homo sapiens_hsa047270.54415514
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54194428
109Glutamatergic synapse_Homo sapiens_hsa047240.53145562
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52864884
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52608650
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52287386
113TNF signaling pathway_Homo sapiens_hsa046680.52163854
114Viral myocarditis_Homo sapiens_hsa054160.51916044
115Cocaine addiction_Homo sapiens_hsa050300.51439375
116Nicotine addiction_Homo sapiens_hsa050330.50983445
117Glioma_Homo sapiens_hsa052140.50057693
118Bladder cancer_Homo sapiens_hsa052190.48845025
119Glycerolipid metabolism_Homo sapiens_hsa005610.48614301
120beta-Alanine metabolism_Homo sapiens_hsa004100.48002020
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47797624
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46878470
123Arachidonic acid metabolism_Homo sapiens_hsa005900.46406674
124MAPK signaling pathway_Homo sapiens_hsa040100.45887809
125Basal cell carcinoma_Homo sapiens_hsa052170.44764791
126Pancreatic secretion_Homo sapiens_hsa049720.44354944
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43963406
128Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41484450

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