CLDN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sulfur amino acid catabolic process (GO:0000098)6.06538559
2desmosome organization (GO:0002934)6.04583672
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.26660422
4L-phenylalanine catabolic process (GO:0006559)5.26660422
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.19326399
6L-phenylalanine metabolic process (GO:0006558)5.19326399
7bile acid and bile salt transport (GO:0015721)5.03675534
8intestinal cholesterol absorption (GO:0030299)4.90246653
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.72546299
10aromatic amino acid family catabolic process (GO:0009074)4.62709056
11positive regulation of Cdc42 GTPase activity (GO:0043089)4.62247460
12cysteine metabolic process (GO:0006534)4.59538329
13ear development (GO:0043583)4.51123267
14high-density lipoprotein particle remodeling (GO:0034375)4.31437453
15urea cycle (GO:0000050)4.29063068
16urea metabolic process (GO:0019627)4.29063068
17epoxygenase P450 pathway (GO:0019373)4.25052233
18intestinal absorption (GO:0050892)4.23738370
19positive regulation of fatty acid beta-oxidation (GO:0032000)4.19784267
20flavonoid metabolic process (GO:0009812)4.19043079
21cellular glucuronidation (GO:0052695)4.15228968
22multicellular organismal water homeostasis (GO:0050891)4.14810235
23tryptophan catabolic process (GO:0006569)4.13838774
24indole-containing compound catabolic process (GO:0042436)4.13838774
25indolalkylamine catabolic process (GO:0046218)4.13838774
26kynurenine metabolic process (GO:0070189)4.08223685
27phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)4.06163889
28NADH metabolic process (GO:0006734)4.06109799
29regulation of triglyceride catabolic process (GO:0010896)4.05173908
30bundle of His cell to Purkinje myocyte communication (GO:0086069)4.00837156
31vitamin transmembrane transport (GO:0035461)3.99428452
32axonemal dynein complex assembly (GO:0070286)3.99324251
33regulation of water loss via skin (GO:0033561)3.98958098
34homocysteine metabolic process (GO:0050667)3.98646729
35reverse cholesterol transport (GO:0043691)3.97969466
36regulation of cholesterol esterification (GO:0010872)3.97812037
37GDP-mannose metabolic process (GO:0019673)3.96559932
38nitrogen cycle metabolic process (GO:0071941)3.92913857
39ethanol metabolic process (GO:0006067)3.92699060
40bile acid biosynthetic process (GO:0006699)3.92304074
41bile acid metabolic process (GO:0008206)3.92161344
42phospholipid efflux (GO:0033700)3.89713791
43glucuronate metabolic process (GO:0019585)3.89183051
44uronic acid metabolic process (GO:0006063)3.89183051
45alpha-linolenic acid metabolic process (GO:0036109)3.88612032
46tryptophan metabolic process (GO:0006568)3.85516694
47negative regulation of sterol transport (GO:0032372)3.84944606
48negative regulation of cholesterol transport (GO:0032375)3.84944606
49plasma lipoprotein particle remodeling (GO:0034369)3.84345103
50protein-lipid complex remodeling (GO:0034368)3.84345103
51macromolecular complex remodeling (GO:0034367)3.84345103
52triglyceride homeostasis (GO:0070328)3.81986643
53acylglycerol homeostasis (GO:0055090)3.81986643
54epithelial cell-cell adhesion (GO:0090136)3.80359890
55regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.80007424
56primary alcohol catabolic process (GO:0034310)3.78926182
57negative regulation of fibrinolysis (GO:0051918)3.78275635
58regulation of bile acid biosynthetic process (GO:0070857)3.77696989
59drug catabolic process (GO:0042737)3.77445016
60glyoxylate metabolic process (GO:0046487)3.76019369
61response to nitrosative stress (GO:0051409)3.75443473
62amyloid precursor protein catabolic process (GO:0042987)3.72405908
63complement activation, alternative pathway (GO:0006957)3.72101500
64regulation of fatty acid beta-oxidation (GO:0031998)3.71086990
65ethanol oxidation (GO:0006069)3.70530650
66regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.69967514
67hepatocyte apoptotic process (GO:0097284)3.68148819
68regulation of apoptotic process involved in morphogenesis (GO:1902337)3.66184566
69pyrimidine-containing compound transmembrane transport (GO:0072531)3.65368377
70regulation of cholesterol homeostasis (GO:2000188)3.65083589
71peptidyl-glutamic acid carboxylation (GO:0017187)3.63604372
72protein carboxylation (GO:0018214)3.63604372
73Golgi transport vesicle coating (GO:0048200)3.62183021
74COPI coating of Golgi vesicle (GO:0048205)3.62183021
75fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.62157844
76amino-acid betaine metabolic process (GO:0006577)3.59868123
77establishment of apical/basal cell polarity (GO:0035089)3.57525059
78regulation of protein activation cascade (GO:2000257)3.56037026
79angiotensin maturation (GO:0002003)3.56017545
80response to food (GO:0032094)3.55583141
81* calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.53338659
82maintenance of gastrointestinal epithelium (GO:0030277)3.51949375
83regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.51656132
84regulation of fibrinolysis (GO:0051917)3.49884978
85glutathione biosynthetic process (GO:0006750)3.47086091
86positive regulation of lipoprotein lipase activity (GO:0051006)3.46022551
87positive regulation of triglyceride lipase activity (GO:0061365)3.46022551
88cellular ketone body metabolic process (GO:0046950)3.45734654
89cellular modified amino acid catabolic process (GO:0042219)3.42749870
90cholesterol efflux (GO:0033344)3.42420794
91cholesterol homeostasis (GO:0042632)3.40424577
92aromatic amino acid family metabolic process (GO:0009072)3.39563643
93positive regulation of cellular amine metabolic process (GO:0033240)3.39551281
94peptidyl-tyrosine autophosphorylation (GO:0038083)3.39319294
95water homeostasis (GO:0030104)3.36760033
96positive regulation of pseudopodium assembly (GO:0031274)3.36658050
97serine family amino acid catabolic process (GO:0009071)3.36336098
98regulation of guanylate cyclase activity (GO:0031282)3.35773661
99sterol homeostasis (GO:0055092)3.35671967
100branching involved in mammary gland duct morphogenesis (GO:0060444)3.34767352
101regulation of complement activation (GO:0030449)3.34492094
102phospholipid homeostasis (GO:0055091)3.34248994
103fructose metabolic process (GO:0006000)3.31515715
104regulation of viral release from host cell (GO:1902186)3.31295685
105renal system process involved in regulation of blood volume (GO:0001977)3.30608103
106interferon-gamma secretion (GO:0072643)3.30130161
107striated muscle atrophy (GO:0014891)3.29337079
108lipoprotein metabolic process (GO:0042157)3.29070405
109regulation of cholesterol metabolic process (GO:0090181)3.29051501
110proline biosynthetic process (GO:0006561)3.25121201
111plasma lipoprotein particle assembly (GO:0034377)3.23071753
112low-density lipoprotein particle remodeling (GO:0034374)3.22431161
113regulation of cholesterol biosynthetic process (GO:0045540)3.21078741
114establishment of skin barrier (GO:0061436)3.20663979
115UDP-N-acetylglucosamine metabolic process (GO:0006047)3.18804048
116glomerular filtration (GO:0003094)3.17666408
117nonribosomal peptide biosynthetic process (GO:0019184)3.17516721
118negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.17174987
119intestinal epithelial cell development (GO:0060576)3.15884993
120benzene-containing compound metabolic process (GO:0042537)3.15412242
121plasma lipoprotein particle clearance (GO:0034381)3.14909718
122endothelial cell chemotaxis (GO:0035767)3.14868617
123purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.12861569
1243-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.12861569
125maternal placenta development (GO:0001893)3.12632447
126xenobiotic catabolic process (GO:0042178)3.11799246
127transcytosis (GO:0045056)3.11703985
128acute-phase response (GO:0006953)3.09817602
129drug metabolic process (GO:0017144)3.09599165
130lysine metabolic process (GO:0006553)3.08697064
131lysine catabolic process (GO:0006554)3.08697064
132exogenous drug catabolic process (GO:0042738)3.07396213
133very-low-density lipoprotein particle assembly (GO:0034379)3.07166258
134regulation of respiratory burst (GO:0060263)3.06707102
135oligosaccharide biosynthetic process (GO:0009312)3.06435347
136O-glycan processing (GO:0016266)3.05774921
137cellular amino acid catabolic process (GO:0009063)3.05286782
138positive regulation of lipid catabolic process (GO:0050996)3.04840989
139positive regulation of respiratory burst (GO:0060267)3.03684472
140motile cilium assembly (GO:0044458)3.03569281
141negative regulation of lipase activity (GO:0060192)3.03466640
142regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.03181294
143regulation of extracellular matrix disassembly (GO:0010715)3.02586282
144alpha-amino acid catabolic process (GO:1901606)3.01962208
145drug transmembrane transport (GO:0006855)3.01862669
146renal filtration (GO:0097205)3.01395865
147protein retention in ER lumen (GO:0006621)3.01120347
148aldehyde catabolic process (GO:0046185)3.00484508
149tight junction assembly (GO:0070830)3.00440158
150tyrosine metabolic process (GO:0006570)3.00199291
151surfactant homeostasis (GO:0043129)3.00088445
152positive regulation of fatty acid oxidation (GO:0046321)2.99322857
153short-chain fatty acid metabolic process (GO:0046459)2.98583943
154regulation of interleukin-13 production (GO:0032656)2.94349891
155regulation of pseudopodium assembly (GO:0031272)2.94261882
156sphingomyelin metabolic process (GO:0006684)2.94158903
157mammary gland epithelial cell differentiation (GO:0060644)2.91600705
158glutamine family amino acid biosynthetic process (GO:0009084)2.91126469
159regulation of cell proliferation involved in kidney development (GO:1901722)2.90540490
160regulation of systemic arterial blood pressure by hormone (GO:0001990)2.89902191
161regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.89902191
162endocrine process (GO:0050886)2.89902191
163glucose 6-phosphate metabolic process (GO:0051156)2.88627187
164skeletal muscle adaptation (GO:0043501)2.87441757
165amyloid precursor protein metabolic process (GO:0042982)2.84647464
166retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.84331702
167establishment of monopolar cell polarity (GO:0061162)2.81333628
168establishment or maintenance of monopolar cell polarity (GO:0061339)2.81333628
169positive regulation of keratinocyte differentiation (GO:0045618)2.80434801
170auditory receptor cell differentiation (GO:0042491)2.80169802
171epithelial structure maintenance (GO:0010669)2.78792543
172positive regulation of epidermal cell differentiation (GO:0045606)2.78486945
173proline metabolic process (GO:0006560)2.76093287
174negative regulation of cell size (GO:0045792)2.74194877
175muscle atrophy (GO:0014889)2.73664272
176antimicrobial humoral response (GO:0019730)2.72913226
177antibacterial humoral response (GO:0019731)2.71190324
178maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70747807
179negative regulation of kidney development (GO:0090185)2.70449207
180sulfate transmembrane transport (GO:1902358)2.69758864
181glucocorticoid biosynthetic process (GO:0006704)2.69558813
182cilium or flagellum-dependent cell motility (GO:0001539)2.68023289
183negative regulation of fatty acid transport (GO:2000192)2.67626608
184negative regulation of cell fate specification (GO:0009996)2.67511426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.67146031
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.72365019
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.38250201
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.63659096
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.48187479
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.14402822
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.79614779
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.51626247
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.15894519
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13807981
11SOX2_27498859_Chip-Seq_STOMACH_Mouse2.92282491
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.85674403
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.77455700
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.59348411
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.39811446
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.35383455
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.35066306
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.31472999
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.24037902
20ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.18616728
21GATA4_25053715_ChIP-Seq_YYC3_Human2.16122952
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.13715553
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.04687237
24ESR1_21235772_ChIP-Seq_MCF-7_Human2.01639913
25ZNF263_19887448_ChIP-Seq_K562_Human2.01134337
26* SOX2_20726797_ChIP-Seq_SW620_Human1.99352747
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.99015404
28CLOCK_20551151_ChIP-Seq_293T_Human1.92886055
29GATA6_25053715_ChIP-Seq_YYC3_Human1.89799651
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70138566
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.69758954
32SMC4_20622854_ChIP-Seq_HELA_Human1.59628771
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.59243366
34P68_20966046_ChIP-Seq_HELA_Human1.54167357
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.52090413
36* RACK7_27058665_Chip-Seq_MCF-7_Human1.51052707
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47856174
38VDR_21846776_ChIP-Seq_THP-1_Human1.47773689
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47711485
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47659005
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47529271
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.47066901
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.43795102
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.43776580
45TCF7_22412390_ChIP-Seq_EML_Mouse1.42888798
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42660571
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41878646
48* FOXA2_19822575_ChIP-Seq_HepG2_Human1.39656909
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38753644
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37960862
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35984566
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.34584705
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31373408
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30902430
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26939545
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.26929089
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25617510
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25097112
59BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.24439554
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22811728
61KDM2B_26808549_Chip-Seq_K562_Human1.19542282
62* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18603498
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17168302
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17114429
65* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16683243
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15789710
67* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11612499
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10858781
69KDM2B_26808549_Chip-Seq_DND41_Human1.10490515
70* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10454229
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08406983
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08074675
73JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07824339
74LXR_22292898_ChIP-Seq_THP-1_Human1.07309779
75BCL6_27268052_Chip-Seq_Bcells_Human1.07208303
76ATF3_27146783_Chip-Seq_COLON_Human1.06055511
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05395657
78* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02888566
79P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02754464
80DROSHA_22980978_ChIP-Seq_HELA_Human1.02044240
81SA1_27219007_Chip-Seq_Bcells_Human1.01922898
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00989593
83GATA3_24758297_ChIP-Seq_MCF-7_Human0.98941405
84ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98791607
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98764343
86CTCF_26484167_Chip-Seq_Bcells_Mouse0.96403291
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94836590
88SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94746830
89E2F1_20622854_ChIP-Seq_HELA_Human0.94463805
90KLF5_25053715_ChIP-Seq_YYC3_Human0.94279308
91PHF8_20622854_ChIP-Seq_HELA_Human0.93790082
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93569904
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93362854
94* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93307678
95RARA_24833708_ChIP-Seq_LIVER_Mouse0.93108253
96FOXA1_25552417_ChIP-Seq_VCAP_Human0.92887263
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90437029
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88488513
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86924076
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86639380
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85990384
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85261383
103BCOR_27268052_Chip-Seq_Bcells_Human0.83936527
104CREB1_26743006_Chip-Seq_LNCaP_Human0.83637835
105SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83578711
106* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83261039
107RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81549730
108PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81516997
109AHR_22903824_ChIP-Seq_MCF-7_Human0.80372515
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80230531
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79651158
112* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77267501
113* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77267501
114* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75814768
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74667258
116CTCF_27219007_Chip-Seq_Bcells_Human0.74458003
117ERG_21242973_ChIP-ChIP_JURKAT_Human0.74380332
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.73998360
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.73270526
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72499939
121RARB_24833708_ChIP-Seq_LIVER_Mouse0.72327424
122* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.71241785
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.69394221
124* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.68527223
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.68439404
126* GATA2_19941826_ChIP-Seq_K562_Human0.68249039
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.68089168
128IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.67921960
129CTCF_20526341_ChIP-Seq_ESCs_Human0.67560096
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.67320574
131GATA1_22025678_ChIP-Seq_K562_Human0.66861887
132TP63_22573176_ChIP-Seq_HFKS_Human0.66519971
133GATA1_19941826_ChIP-Seq_K562_Human0.66497173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.21123353
2MP0005360_urolithiasis5.78099198
3MP0005085_abnormal_gallbladder_physiolo5.09561996
4MP0010234_abnormal_vibrissa_follicle4.81609832
5MP0005365_abnormal_bile_salt4.73985574
6MP0008875_abnormal_xenobiotic_pharmacok4.20833836
7MP0001666_abnormal_nutrient_absorption3.82490721
8MP0003252_abnormal_bile_duct3.39229299
9MP0003806_abnormal_nucleotide_metabolis3.32507917
10MP0005083_abnormal_biliary_tract2.93890875
11MP0010329_abnormal_lipoprotein_level2.68838239
12MP0005377_hearing/vestibular/ear_phenot2.43236962
13MP0003878_abnormal_ear_physiology2.43236962
14MP0004264_abnormal_extraembryonic_tissu2.42544996
15MP0009840_abnormal_foam_cell2.38059415
16MP0002138_abnormal_hepatobiliary_system2.31635528
17MP0003191_abnormal_cellular_cholesterol2.22862158
18MP0003183_abnormal_peptide_metabolism2.16375935
19MP0009379_abnormal_foot_pigmentation2.15944145
20MP0005409_darkened_coat_color2.06050646
21MP0004782_abnormal_surfactant_physiolog2.01676087
22MP0003868_abnormal_feces_composition1.98932074
23MP0004019_abnormal_vitamin_homeostasis1.96149065
24MP0000678_abnormal_parathyroid_gland1.94869311
25MP0005076_abnormal_cell_differentiation1.94573001
26MP0005332_abnormal_amino_acid1.89016466
27MP0002249_abnormal_larynx_morphology1.77484790
28MP0009780_abnormal_chondrocyte_physiolo1.74396335
29MP0005058_abnormal_lysosome_morphology1.66868792
30MP0000462_abnormal_digestive_system1.65605867
31MP0002118_abnormal_lipid_homeostasis1.63652699
32MP0004858_abnormal_nervous_system1.59790025
33MP0009643_abnormal_urine_homeostasis1.57967775
34MP0000609_abnormal_liver_physiology1.56734984
35MP0003879_abnormal_hair_cell1.56045145
36MP0003123_paternal_imprinting1.54016958
37MP0002796_impaired_skin_barrier1.53908376
38MP0010352_gastrointestinal_tract_polyps1.50289934
39MP0003705_abnormal_hypodermis_morpholog1.46907869
40MP0003195_calcinosis1.39023595
41MP0000537_abnormal_urethra_morphology1.31860679
42MP0005084_abnormal_gallbladder_morpholo1.29806851
43MP0003866_abnormal_defecation1.29489828
44MP0010678_abnormal_skin_adnexa1.27934305
45MP0005319_abnormal_enzyme/_coenzyme1.27455874
46MP0001873_stomach_inflammation1.27247125
47MP0000681_abnormal_thyroid_gland1.27041250
48MP0002098_abnormal_vibrissa_morphology1.25999847
49MP0003300_gastrointestinal_ulcer1.24349533
50MP0002254_reproductive_system_inflammat1.23115151
51MP0003453_abnormal_keratinocyte_physiol1.22945327
52MP0000627_abnormal_mammary_gland1.20147775
53MP0005220_abnormal_exocrine_pancreas1.18959157
54MP0010155_abnormal_intestine_physiology1.17718026
55MP0005636_abnormal_mineral_homeostasis1.12676897
56MP0001663_abnormal_digestive_system1.10094162
57MP0005381_digestive/alimentary_phenotyp1.08309823
58MP0000477_abnormal_intestine_morphology1.04334715
59MP0004381_abnormal_hair_follicle1.03666252
60MP0001664_abnormal_digestion0.95617148
61MP0008004_abnormal_stomach_pH0.95424760
62MP0005670_abnormal_white_adipose0.95153567
63MP0005408_hypopigmentation0.95102237
64MP0010030_abnormal_orbit_morphology0.90031938
65MP0009053_abnormal_anal_canal0.89978562
66MP0002132_abnormal_respiratory_system0.88783176
67MP0005584_abnormal_enzyme/coenzyme_acti0.88042968
68MP0000427_abnormal_hair_cycle0.87111584
69MP0001727_abnormal_embryo_implantation0.86885557
70MP0000566_synostosis0.85140492
71MP0001765_abnormal_ion_homeostasis0.84505313
72MP0010771_integument_phenotype0.82799754
73MP0001756_abnormal_urination0.82562142
74MP0001764_abnormal_homeostasis0.82155325
75MP0004185_abnormal_adipocyte_glucose0.81360232
76MP0000470_abnormal_stomach_morphology0.80258265
77MP0003283_abnormal_digestive_organ0.79040818
78MP0005666_abnormal_adipose_tissue0.78975724
79MP0002896_abnormal_bone_mineralization0.78139626
80MP0001346_abnormal_lacrimal_gland0.77687754
81MP0002909_abnormal_adrenal_gland0.77671916
82MP0000490_abnormal_crypts_of0.77291224
83MP0002653_abnormal_ependyma_morphology0.76562564
84MP0000538_abnormal_urinary_bladder0.76504426
85MP0005451_abnormal_body_composition0.76044690
86MP0000467_abnormal_esophagus_morphology0.75791590
87MP0003186_abnormal_redox_activity0.75736908
88MP0000613_abnormal_salivary_gland0.75476820
89MP0001849_ear_inflammation0.74614929
90MP0009931_abnormal_skin_appearance0.74614854
91MP0002822_catalepsy0.72843784
92MP0005501_abnormal_skin_physiology0.72715918
93MP0000598_abnormal_liver_morphology0.72431441
94MP0002060_abnormal_skin_morphology0.71775529
95MP0003938_abnormal_ear_development0.71208920
96MP0001881_abnormal_mammary_gland0.69939902
97MP0002089_abnormal_postnatal_growth/wei0.69686311
98MP0003936_abnormal_reproductive_system0.69356949
99MP0002136_abnormal_kidney_physiology0.68995938
100MP0008260_abnormal_autophagy0.68154468
101MP0005375_adipose_tissue_phenotype0.67408313
102MP0009642_abnormal_blood_homeostasis0.67009302
103MP0005310_abnormal_salivary_gland0.66375944
104MP0003566_abnormal_cell_adhesion0.63137515
105MP0009764_decreased_sensitivity_to0.62260404
106MP0004043_abnormal_pH_regulation0.62253559
107MP0005647_abnormal_sex_gland0.61964547
108MP0002928_abnormal_bile_duct0.61840667
109MP0005167_abnormal_blood-brain_barrier0.61659714
110MP0005166_decreased_susceptibility_to0.61222300
111MP0005248_abnormal_Harderian_gland0.60838989
112MP0001216_abnormal_epidermal_layer0.59444450
113MP0002295_abnormal_pulmonary_circulatio0.59432697
114MP0000383_abnormal_hair_follicle0.58372177
115MP0001944_abnormal_pancreas_morphology0.57488665
116MP0008469_abnormal_protein_level0.53846083
117MP0001485_abnormal_pinna_reflex0.52556577
118MP0002876_abnormal_thyroid_physiology0.52041831
119MP0004947_skin_inflammation0.50391613
120MP0002078_abnormal_glucose_homeostasis0.50043454
121MP0003011_delayed_dark_adaptation0.49831834
122MP0000377_abnormal_hair_follicle0.49297350
123MP0005448_abnormal_energy_balance0.48905633
124MP0003656_abnormal_erythrocyte_physiolo0.48618758
125MP0003638_abnormal_response/metabolism_0.48122221
126MP0009763_increased_sensitivity_to0.47862774
127MP0009765_abnormal_xenobiotic_induced0.47542159
128MP0002277_abnormal_respiratory_mucosa0.46658154
129MP0000604_amyloidosis0.46362125
130MP0009384_cardiac_valve_regurgitation0.45163053
131MP0005023_abnormal_wound_healing0.45133414
132MP0000579_abnormal_nail_morphology0.44990753
133MP0008872_abnormal_physiological_respon0.43434685

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.86473680
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.53985456
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.44529523
4Deep venous thrombosis (HP:0002625)5.19239242
5Hypobetalipoproteinemia (HP:0003563)4.76004161
6Xanthomatosis (HP:0000991)4.64391556
7Right ventricular cardiomyopathy (HP:0011663)4.60229810
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.60118851
9Prolonged partial thromboplastin time (HP:0003645)4.48840616
10Fat malabsorption (HP:0002630)4.08712017
11Chronic bronchitis (HP:0004469)4.05839329
12Abnormality of glutamine family amino acid metabolism (HP:0010902)3.95174804
13Distal lower limb muscle weakness (HP:0009053)3.83837981
14Decreased circulating renin level (HP:0003351)3.74200912
15Abnormal respiratory motile cilium morphology (HP:0005938)3.72088785
16Abnormal respiratory epithelium morphology (HP:0012253)3.72088785
17Hyperlipoproteinemia (HP:0010980)3.71357701
18Abnormal respiratory motile cilium physiology (HP:0012261)3.71096285
19Hypolipoproteinemia (HP:0010981)3.69164274
20Complement deficiency (HP:0004431)3.68185686
21Malnutrition (HP:0004395)3.67011340
22Rhinitis (HP:0012384)3.59413561
23Gout (HP:0001997)3.58428811
24Ileus (HP:0002595)3.55708504
25Conjugated hyperbilirubinemia (HP:0002908)3.54642668
26Hyperammonemia (HP:0001987)3.49066786
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.46000557
28Abnormal ciliary motility (HP:0012262)3.45897176
29Esophageal varix (HP:0002040)3.39526294
30Nasal polyposis (HP:0100582)3.39469461
31Hypoglycemic coma (HP:0001325)3.35675779
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.31820698
33J-shaped sella turcica (HP:0002680)3.27389561
34Hypoalphalipoproteinemia (HP:0003233)3.25400881
35Late onset (HP:0003584)3.19014711
36Ketosis (HP:0001946)3.18073286
37Abnormality of renin-angiotensin system (HP:0000847)3.17846202
38Absent/shortened dynein arms (HP:0200106)3.17632035
39Dynein arm defect of respiratory motile cilia (HP:0012255)3.17632035
40Hyperglycinuria (HP:0003108)3.15554501
41Abnormality of the intrinsic pathway (HP:0010989)3.15356915
42Abdominal distention (HP:0003270)3.15278204
43Abnormality of the nasal mucosa (HP:0000433)3.14370587
44Abnormality of the common coagulation pathway (HP:0010990)3.12616858
45Abnormality of purine metabolism (HP:0004352)3.02995831
46Thin bony cortex (HP:0002753)3.02738596
47Joint hemorrhage (HP:0005261)3.02591137
48Epidermoid cyst (HP:0200040)3.00777238
49Hypercholesterolemia (HP:0003124)2.96924660
50Amelogenesis imperfecta (HP:0000705)2.94764025
51Hyperparathyroidism (HP:0000843)2.94567589
52Onycholysis (HP:0001806)2.93362911
53Steatorrhea (HP:0002570)2.92253567
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.91742705
55Bronchiectasis (HP:0002110)2.87854442
56Hyperactive renin-angiotensin system (HP:0000841)2.87213391
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.84040465
58Abnormality of fatty-acid metabolism (HP:0004359)2.83504997
59Septate vagina (HP:0001153)2.81157202
60Hyperglycinemia (HP:0002154)2.80522840
61Ketoacidosis (HP:0001993)2.75870691
62Abnormality of nucleobase metabolism (HP:0010932)2.74453664
63Hyperacusis (HP:0010780)2.73281501
64Abnormality of complement system (HP:0005339)2.73040828
65Abnormality of glycine metabolism (HP:0010895)2.72999707
66Abnormality of serine family amino acid metabolism (HP:0010894)2.72999707
67Curly hair (HP:0002212)2.72428754
68Abnormal cartilage morphology (HP:0002763)2.70935929
69Abnormality of the distal phalanges of the toes (HP:0010182)2.67366809
70Vascular calcification (HP:0004934)2.63918431
71Flat acetabular roof (HP:0003180)2.63047777
72Spinal cord compression (HP:0002176)2.59663229
73Interstitial pulmonary disease (HP:0006530)2.57707611
74Flattened epiphyses (HP:0003071)2.57396187
75Hepatocellular carcinoma (HP:0001402)2.56568452
76Abnormal tarsal ossification (HP:0008369)2.52077457
77Pili torti (HP:0003777)2.49036537
78Hyperphosphatemia (HP:0002905)2.46896409
79Hyperbilirubinemia (HP:0002904)2.44980857
80Abnormality of methionine metabolism (HP:0010901)2.44872631
81Stridor (HP:0010307)2.43089605
82Increased purine levels (HP:0004368)2.41358986
83Hyperuricemia (HP:0002149)2.41358986
84Dicarboxylic aciduria (HP:0003215)2.40911297
85Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40911297
86Germ cell neoplasia (HP:0100728)2.37726823
87Pustule (HP:0200039)2.36714786
88Micronodular cirrhosis (HP:0001413)2.35077994
89Bell-shaped thorax (HP:0001591)2.33496798
90Renal tubular acidosis (HP:0001947)2.33090042
91Cardiovascular calcification (HP:0011915)2.32229344
92Amyloidosis (HP:0011034)2.27442762
93Metabolic acidosis (HP:0001942)2.26443191
94Lymphangioma (HP:0100764)2.26357743
95Mildly elevated creatine phosphokinase (HP:0008180)2.24329592
96Hyperaldosteronism (HP:0000859)2.23635977
97Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.23404281
98Upper limb amyotrophy (HP:0009129)2.22125746
99Distal upper limb amyotrophy (HP:0007149)2.22125746
100Metabolic alkalosis (HP:0200114)2.20142580
101Glomerulosclerosis (HP:0000096)2.20127341
102Fragile nails (HP:0001808)2.19364912
103Growth hormone excess (HP:0000845)2.18745640
104Abnormality of small intestinal villus morphology (HP:0011472)2.18369562
105Villous atrophy (HP:0011473)2.18369562
106Abnormality of pyrimidine metabolism (HP:0004353)2.17369329
107Abnormality of proline metabolism (HP:0010907)2.16851164
108Hydroxyprolinuria (HP:0003080)2.16851164
109Alopecia of scalp (HP:0002293)2.16324550
110Asymmetry of the thorax (HP:0001555)2.12782829
111Concave nail (HP:0001598)2.12652340
112Renal salt wasting (HP:0000127)2.12381456
113Tubulointerstitial fibrosis (HP:0005576)2.12073236
114Lethargy (HP:0001254)2.10106534
115Visceral angiomatosis (HP:0100761)2.09469642
116Abnormality of the distal phalanx of the thumb (HP:0009617)2.09109473
117Abnormality of vitamin metabolism (HP:0100508)2.08694071
118Palpitations (HP:0001962)2.08360933
119Sensorimotor neuropathy (HP:0007141)2.06394297
120Respiratory distress (HP:0002098)2.05574416
121Pancreatitis (HP:0001733)2.05492553
122Hypoglycemic seizures (HP:0002173)2.05444639
123Potter facies (HP:0002009)2.03875207
124Facial shape deformation (HP:0011334)2.03875207
125Bronchitis (HP:0012387)2.03425236
126Spontaneous abortion (HP:0005268)2.03367069
127Abnormality of the gastric mucosa (HP:0004295)2.01120697
128Glycosuria (HP:0003076)2.00162831
129Abnormality of urine glucose concentration (HP:0011016)2.00162831
130Cervical subluxation (HP:0003308)1.99229700
131Widely patent fontanelles and sutures (HP:0004492)1.98213580
132Severe short stature (HP:0003510)1.96954125
133Dehydration (HP:0001944)1.96645532
134Diaphragmatic weakness (HP:0009113)1.96531290
135Hemorrhage of the eye (HP:0011885)1.96084110
136Flat capital femoral epiphysis (HP:0003370)1.94740167
137Alkalosis (HP:0001948)1.94669958
138Hypotension (HP:0002615)1.94256009
139Systemic lupus erythematosus (HP:0002725)1.94074331
140Abnormality of carpal bone ossification (HP:0006257)1.93307265
141Abnormal hair laboratory examination (HP:0003328)1.93157156
142Hypophosphatemia (HP:0002148)1.93064219
143Acanthocytosis (HP:0001927)1.92748956
144Stroke (HP:0001297)1.91489239
145Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.91025341
146Goiter (HP:0000853)1.90342562
147Insulin resistance (HP:0000855)1.90158717
148Delayed CNS myelination (HP:0002188)1.89275303
149Bulbar palsy (HP:0001283)1.88477447
150Woolly hair (HP:0002224)1.88427972
151Tachypnea (HP:0002789)1.87608544
152Abnormal biliary tract morphology (HP:0012440)1.86672711
153Hyponatremia (HP:0002902)1.86608492
154Bronchomalacia (HP:0002780)1.86418974
155Abnormality of chloride homeostasis (HP:0011422)1.85287104
156Abnormal vertebral ossification (HP:0100569)1.83628294
157Myocardial infarction (HP:0001658)1.83485655
158Hemangiomatosis (HP:0007461)1.82881001
159Symptomatic seizures (HP:0011145)1.80987739
160Ulnar claw (HP:0001178)1.80908285
161Hypercalciuria (HP:0002150)1.80677834
162Abnormality of permanent molar morphology (HP:0011071)1.80571283
163Abnormality of the dental root (HP:0006486)1.80571283
164Taurodontia (HP:0000679)1.80571283
165Progressive sensorineural hearing impairment (HP:0000408)1.79530741
166Focal segmental glomerulosclerosis (HP:0000097)1.78841654
167Congenital glaucoma (HP:0001087)1.76652209
168Atelectasis (HP:0100750)1.74314233
169Adrenal overactivity (HP:0002717)1.72924914
170Chronic sinusitis (HP:0011109)1.72230981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK15.35021616
2EPHA24.12660292
3MST1R3.40262393
4FRK3.29575391
5ARAF3.06099792
6TAOK32.92887435
7BCKDK2.69802270
8SMG12.69010459
9MAP2K22.67457249
10ERN12.66256380
11EPHB22.39598107
12LMTK22.36917243
13PIK3CA2.31964736
14PIM22.17427480
15MST42.10432483
16MAP3K22.07883427
17MAP3K32.06434895
18SIK12.03904320
19PTK61.88834886
20FGFR41.86893468
21MAPK151.84050132
22MUSK1.73880383
23TRIB31.71992087
24TAOK11.56298255
25TESK11.47869805
26PRKG21.44245990
27TESK21.42046289
28FER1.41099970
29NME21.35272754
30MYLK1.34645658
31MAP3K111.30486374
32LATS11.25863460
33DDR21.24207985
34BRAF1.23768681
35MET1.22274913
36INSRR1.20462784
37RPS6KB21.18706642
38PTK21.16247203
39NEK61.13013239
40PKN21.08878578
41PRKCI1.08085033
42NME11.07359727
43MAP2K11.03285045
44AKT31.02150546
45MATK1.01208678
46ERBB20.99934343
47EPHB10.99001833
48MAP2K60.96558828
49GRK60.93453901
50DAPK20.93084423
51DYRK1B0.91239278
52ILK0.90216558
53CAMK2G0.87462905
54STK38L0.85663018
55MAP2K30.84819326
56ACVR1B0.84482348
57PRKD20.78443463
58MAP3K10.78290798
59ICK0.74622076
60GSK3A0.71783835
61PIK3CG0.70023607
62ERBB40.67641352
63MAPK110.67030807
64PAK40.66067692
65TAOK20.64909837
66SCYL20.63325678
67TBK10.62775976
68EPHA30.62634768
69KSR20.61471216
70STK240.60058279
71MTOR0.59397502
72CSK0.59381884
73MAP3K100.58823950
74CDC42BPA0.58068362
75GRK10.57606224
76RET0.57566622
77CAMK2D0.56059241
78DMPK0.55109363
79MAPKAPK30.53598982
80IRAK30.53092427
81NUAK10.53016863
82WNK40.52853248
83PRPF4B0.52145089
84LRRK20.48694898
85PDGFRA0.47633840
86FGFR20.47484091
87STK380.47318965
88EEF2K0.45262709
89VRK20.44570777
90MAP3K70.43506669
91MAP3K120.43416423
92MAP3K80.41786446
93SIK30.41710293
94CAMK2B0.41621559
95RPS6KA20.41171769
96PDK10.40992953
97HIPK20.40641646
98RPS6KL10.40568698
99RPS6KC10.40568698
100TGFBR20.40195495
101TYK20.39941989
102PRKD10.39238468
103STK390.37124613
104LIMK10.36440272
105PDPK10.36177030
106PRKAA20.34973882
107MAPKAPK20.34950791
108MARK20.34267623
109ABL20.33604868
110NEK90.32520310
111RAF10.32040091
112RPS6KA60.30844233
113IKBKE0.30336582
114MAP3K140.29794154
115PRKCZ0.29190679
116TNK20.28993550
117STK100.28207291
118CDK60.27052442
119CHUK0.26289577
120RPS6KA10.25538344
121CAMKK10.25157277
122CDK70.25055414
123MELK0.24982101
124PRKCD0.24746633
125PRKCQ0.23774196
126IRAK20.23495011
127BMX0.22687753
128TLK10.22159237
129IRAK10.20778719
130IKBKB0.20433710
131JAK20.19956067
132KDR0.19514497
133PDGFRB0.18856996
134PAK30.18815514
135DAPK30.18769029
136CSNK1A10.18705317
137SRC0.18110157

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.76521961
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.27195315
3Sulfur metabolism_Homo sapiens_hsa009203.22070532
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.70711059
5Tryptophan metabolism_Homo sapiens_hsa003802.58166861
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.55886497
7Fatty acid degradation_Homo sapiens_hsa000712.47754153
8Fat digestion and absorption_Homo sapiens_hsa049752.46797741
9Nitrogen metabolism_Homo sapiens_hsa009102.44175854
10Histidine metabolism_Homo sapiens_hsa003402.41828056
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.30662634
12Arginine biosynthesis_Homo sapiens_hsa002202.28453369
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.22085727
14Chemical carcinogenesis_Homo sapiens_hsa052042.19910964
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13449038
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.02068437
17Caffeine metabolism_Homo sapiens_hsa002321.96876122
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.94398012
19Complement and coagulation cascades_Homo sapiens_hsa046101.88015527
20Bile secretion_Homo sapiens_hsa049761.82683110
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.82085345
22PPAR signaling pathway_Homo sapiens_hsa033201.78559842
23beta-Alanine metabolism_Homo sapiens_hsa004101.74811521
24Butanoate metabolism_Homo sapiens_hsa006501.72808079
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.70494825
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.70055279
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69894717
28Pyruvate metabolism_Homo sapiens_hsa006201.69854207
29Peroxisome_Homo sapiens_hsa041461.64931863
30Propanoate metabolism_Homo sapiens_hsa006401.62463844
31Retinol metabolism_Homo sapiens_hsa008301.53106269
32Starch and sucrose metabolism_Homo sapiens_hsa005001.47502585
33Folate biosynthesis_Homo sapiens_hsa007901.38128441
34Fatty acid metabolism_Homo sapiens_hsa012121.37426458
35Phenylalanine metabolism_Homo sapiens_hsa003601.35563553
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33816629
37Selenocompound metabolism_Homo sapiens_hsa004501.30690741
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29367629
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28875658
40Mineral absorption_Homo sapiens_hsa049781.28033795
41Glutathione metabolism_Homo sapiens_hsa004801.26079936
42Sphingolipid metabolism_Homo sapiens_hsa006001.23644864
43Sulfur relay system_Homo sapiens_hsa041221.23531034
44Tyrosine metabolism_Homo sapiens_hsa003501.23375803
45Arginine and proline metabolism_Homo sapiens_hsa003301.14901049
46ABC transporters_Homo sapiens_hsa020101.14607873
47Vitamin digestion and absorption_Homo sapiens_hsa049771.08433541
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04268339
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04190946
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02895458
51Glycerolipid metabolism_Homo sapiens_hsa005611.00459897
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99751230
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97490694
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.96919420
55Vibrio cholerae infection_Homo sapiens_hsa051100.95307735
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.92141632
57Notch signaling pathway_Homo sapiens_hsa043300.92105091
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89446489
59Carbon metabolism_Homo sapiens_hsa012000.89090821
60Staphylococcus aureus infection_Homo sapiens_hsa051500.88692980
61Fructose and mannose metabolism_Homo sapiens_hsa000510.85133293
62Galactose metabolism_Homo sapiens_hsa000520.83839917
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83674562
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82582159
65Steroid biosynthesis_Homo sapiens_hsa001000.81564527
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78374458
67Biosynthesis of amino acids_Homo sapiens_hsa012300.76098486
68Fatty acid elongation_Homo sapiens_hsa000620.75944773
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75428290
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.75232262
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73460980
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73332489
73AMPK signaling pathway_Homo sapiens_hsa041520.71914510
74Linoleic acid metabolism_Homo sapiens_hsa005910.70641723
75Renin-angiotensin system_Homo sapiens_hsa046140.66036263
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64814016
77Pentose phosphate pathway_Homo sapiens_hsa000300.61837172
78Protein digestion and absorption_Homo sapiens_hsa049740.60868300
79Bladder cancer_Homo sapiens_hsa052190.52487697
80Insulin signaling pathway_Homo sapiens_hsa049100.52233111
81Acute myeloid leukemia_Homo sapiens_hsa052210.51876150
82* Tight junction_Homo sapiens_hsa045300.49786309
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47677808
84Pancreatic secretion_Homo sapiens_hsa049720.45928812
85Metabolic pathways_Homo sapiens_hsa011000.45723941
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.43547594
87Lysosome_Homo sapiens_hsa041420.43214317
88Lysine degradation_Homo sapiens_hsa003100.42135876
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41637957
90Choline metabolism in cancer_Homo sapiens_hsa052310.40738328
91N-Glycan biosynthesis_Homo sapiens_hsa005100.38005443
92VEGF signaling pathway_Homo sapiens_hsa043700.37433833
93Glucagon signaling pathway_Homo sapiens_hsa049220.37169036
94Fatty acid biosynthesis_Homo sapiens_hsa000610.36498455
95* Hepatitis C_Homo sapiens_hsa051600.35792426
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35120123
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34508063
98Thyroid hormone synthesis_Homo sapiens_hsa049180.33669720
99Estrogen signaling pathway_Homo sapiens_hsa049150.31716052
100Arachidonic acid metabolism_Homo sapiens_hsa005900.30413028
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.28757218
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26595017
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23963907
104ErbB signaling pathway_Homo sapiens_hsa040120.23679453
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20785602
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.20379420
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19234869
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18706078
109Adherens junction_Homo sapiens_hsa045200.18007984
110Insulin resistance_Homo sapiens_hsa049310.17903301
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17392499
112Prostate cancer_Homo sapiens_hsa052150.16753543
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16450907
114Prion diseases_Homo sapiens_hsa050200.16376960
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16037532
116* Leukocyte transendothelial migration_Homo sapiens_hsa046700.10703485
117Thyroid cancer_Homo sapiens_hsa052160.08593368
118Endometrial cancer_Homo sapiens_hsa052130.08132919
119Amoebiasis_Homo sapiens_hsa051460.04433482
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.03838802
121Vitamin B6 metabolism_Homo sapiens_hsa007500.01587207
122Other glycan degradation_Homo sapiens_hsa005110.00315566
123ECM-receptor interaction_Homo sapiens_hsa04512-0.0276558
124Ether lipid metabolism_Homo sapiens_hsa00565-0.0127942
125One carbon pool by folate_Homo sapiens_hsa00670-0.0062018

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