CLDN23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.91048741
2desmosome organization (GO:0002934)8.01763872
3multicellular organismal water homeostasis (GO:0050891)6.93953960
4keratinization (GO:0031424)6.64998369
5bundle of His cell to Purkinje myocyte communication (GO:0086069)6.37093358
6intestinal epithelial cell development (GO:0060576)5.97784199
7water homeostasis (GO:0030104)5.56195339
8positive regulation of interleukin-8 secretion (GO:2000484)5.46244664
9G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.37275137
10detection of bacterium (GO:0016045)5.34063081
11regulation of transforming growth factor beta1 production (GO:0032908)5.26563108
12positive regulation of glomerulus development (GO:0090193)5.19638900
13keratinocyte differentiation (GO:0030216)4.99082969
14glycosphingolipid catabolic process (GO:0046479)4.93930149
15epidermal cell differentiation (GO:0009913)4.80163268
16keratinocyte proliferation (GO:0043616)4.72716246
17detection of other organism (GO:0098543)4.69119858
18* calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.68818880
19chemical homeostasis within a tissue (GO:0048875)4.66191071
20regulation of vitamin metabolic process (GO:0030656)4.58768441
21sphingoid metabolic process (GO:0046519)4.58051182
22oligosaccharide catabolic process (GO:0009313)4.55860311
23glycolipid catabolic process (GO:0019377)4.54937186
24regulation of cell proliferation involved in kidney development (GO:1901722)4.43194940
25hair cell differentiation (GO:0035315)4.41598821
26auditory receptor cell differentiation (GO:0042491)4.16279569
27phosphatidylserine acyl-chain remodeling (GO:0036150)4.11438450
28surfactant homeostasis (GO:0043129)4.01972683
29diol metabolic process (GO:0034311)3.99716466
30regulation of mononuclear cell migration (GO:0071675)3.99385845
31regulation of interleukin-8 secretion (GO:2000482)3.95561070
32regulation of chemokine secretion (GO:0090196)3.94807616
33ceramide catabolic process (GO:0046514)3.94659102
34eosinophil chemotaxis (GO:0048245)3.94066112
35angiotensin maturation (GO:0002003)3.92000414
36membrane lipid catabolic process (GO:0046466)3.79826876
37adhesion of symbiont to host cell (GO:0044650)3.75246980
38virion attachment to host cell (GO:0019062)3.75246980
39sphingolipid catabolic process (GO:0030149)3.72750516
40keratinocyte development (GO:0003334)3.72090136
41phosphatidylinositol acyl-chain remodeling (GO:0036149)3.69273172
42antibacterial humoral response (GO:0019731)3.66178666
43sphingosine metabolic process (GO:0006670)3.65666524
44regulation of glomerulus development (GO:0090192)3.65085284
45regulation of vitamin D biosynthetic process (GO:0060556)3.64483811
463-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.60921643
47purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.60921643
48interferon-gamma secretion (GO:0072643)3.59270319
49glandular epithelial cell differentiation (GO:0002067)3.59058085
50inner ear receptor cell differentiation (GO:0060113)3.58221476
51hormone catabolic process (GO:0042447)3.56832567
52phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.54720743
53phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.47653113
54regulation of ruffle assembly (GO:1900027)3.46202263
55eosinophil migration (GO:0072677)3.45823589
56skin morphogenesis (GO:0043589)3.45782778
57negative regulation of keratinocyte proliferation (GO:0010839)3.44918422
58pyrimidine-containing compound transmembrane transport (GO:0072531)3.44495955
59epoxygenase P450 pathway (GO:0019373)3.42967896
60amyloid precursor protein catabolic process (GO:0042987)3.36969897
61antimicrobial humoral response (GO:0019730)3.36725278
62purinergic nucleotide receptor signaling pathway (GO:0035590)3.34552692
63phospholipid efflux (GO:0033700)3.34319482
64lung secretory cell differentiation (GO:0061140)3.32674463
65peptide catabolic process (GO:0043171)3.29382112
66transepithelial transport (GO:0070633)3.27166573
67adhesion of symbiont to host (GO:0044406)3.26312209
68ectoderm development (GO:0007398)3.25084335
69transcytosis (GO:0045056)3.24055206
70negative regulation of cell fate commitment (GO:0010454)3.23507818
71ethanol oxidation (GO:0006069)3.21915930
72epidermis development (GO:0008544)3.20643186
73barbed-end actin filament capping (GO:0051016)3.19768811
74regulation of chromatin binding (GO:0035561)3.19163199
75maintenance of gastrointestinal epithelium (GO:0030277)3.18865304
76phosphatidylserine metabolic process (GO:0006658)3.18454438
77hemidesmosome assembly (GO:0031581)3.16960251
78G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.16836856
79peptide cross-linking (GO:0018149)3.16764363
80regulation of guanylate cyclase activity (GO:0031282)3.16104693
81eyelid development in camera-type eye (GO:0061029)3.14671567
82hepatocyte apoptotic process (GO:0097284)3.13051074
83phospholipid scrambling (GO:0017121)3.12669824
84fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.12601500
85positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.09096773
86cellular response to thyroid hormone stimulus (GO:0097067)3.07958682
87branching involved in labyrinthine layer morphogenesis (GO:0060670)3.07201235
88regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.06762846
89sensory perception of smell (GO:0007608)3.05740688
90negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.04809677
91regulation of podosome assembly (GO:0071801)3.04700452
92fat-soluble vitamin biosynthetic process (GO:0042362)3.04469373
93defense response to fungus (GO:0050832)3.02746135
94cyclooxygenase pathway (GO:0019371)3.01844353
95mucosal immune response (GO:0002385)3.00295363
96regulation of heart rate by cardiac conduction (GO:0086091)2.99120878
97intestinal absorption (GO:0050892)2.96045815
98columnar/cuboidal epithelial cell development (GO:0002066)2.94356326
99regulation of cholesterol storage (GO:0010885)2.93427084
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.92813447
101regulation of cytokine secretion involved in immune response (GO:0002739)2.92458994
102positive regulation of cholesterol efflux (GO:0010875)2.90559468
103ethanol metabolic process (GO:0006067)2.87821483
104regulation of cholesterol homeostasis (GO:2000188)2.87400863
105thrombin receptor signaling pathway (GO:0070493)2.86658431
106positive regulation of chemokine biosynthetic process (GO:0045080)2.85376516
107* tight junction assembly (GO:0070830)2.85374820
108positive regulation of actin filament depolymerization (GO:0030836)2.85312425
109copper ion transport (GO:0006825)2.82866111
110organ or tissue specific immune response (GO:0002251)2.81613348
111regulation of membrane protein ectodomain proteolysis (GO:0051043)2.80413843
112regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.75023104
113regulation of macrophage chemotaxis (GO:0010758)2.74839779
114glutathione biosynthetic process (GO:0006750)2.73644761
115positive regulation of transforming growth factor beta production (GO:0071636)2.73592839
116beta-amyloid metabolic process (GO:0050435)2.71056270
117negative regulation of transcription regulatory region DNA binding (GO:2000678)2.69617235
118epithelial structure maintenance (GO:0010669)2.68693221
119response to peptidoglycan (GO:0032494)2.67675011
120renal system process involved in regulation of blood volume (GO:0001977)2.67549906
121flavonoid metabolic process (GO:0009812)2.67101876
122positive regulation of cholesterol transport (GO:0032376)2.66171977
123positive regulation of sterol transport (GO:0032373)2.66171977
124primary alcohol catabolic process (GO:0034310)2.65823729
125phosphatidylcholine acyl-chain remodeling (GO:0036151)2.65503472
126cardiac conduction (GO:0061337)2.63880522
127ganglion development (GO:0061548)2.63685578
128hair cycle (GO:0042633)2.63331822
129molting cycle (GO:0042303)2.63331822
130ventricular cardiac muscle cell action potential (GO:0086005)2.62284073
131positive regulation of guanylate cyclase activity (GO:0031284)2.60747395
132lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60626306
133response to thyroid hormone (GO:0097066)2.58945632
134amino sugar catabolic process (GO:0046348)2.57286450
135cellular glucuronidation (GO:0052695)2.57217482
136fructose metabolic process (GO:0006000)2.56949719
137protein localization to endosome (GO:0036010)2.55925273
138monocyte chemotaxis (GO:0002548)2.55236325
139intestinal cholesterol absorption (GO:0030299)2.54465380
140vitamin D metabolic process (GO:0042359)2.53484149
141uronic acid metabolic process (GO:0006063)2.52081410
142cellular response to cadmium ion (GO:0071276)2.51763479
143innate immune response in mucosa (GO:0002227)2.51327234
144sulfate transmembrane transport (GO:1902358)2.50457231
145positive regulation of extracellular matrix organization (GO:1903055)2.50198988
146regulation of cholesterol efflux (GO:0010874)2.49547798
147adipose tissue development (GO:0060612)2.49148927
148nonribosomal peptide biosynthetic process (GO:0019184)2.48514225
149glucuronate metabolic process (GO:0019585)2.48249079
150macrophage activation involved in immune response (GO:0002281)2.47692628
151NIK/NF-kappaB signaling (GO:0038061)2.47571420
152negative regulation of interleukin-12 production (GO:0032695)2.47320026
153regulation of chemokine biosynthetic process (GO:0045073)2.47229499
154apoptotic cell clearance (GO:0043277)2.46563783
155sphingomyelin metabolic process (GO:0006684)2.44905140
156positive regulation of tissue remodeling (GO:0034105)2.44073128
157immunoglobulin mediated immune response (GO:0016064)2.42462077
158bile acid and bile salt transport (GO:0015721)2.40947937
159epithelial cell-cell adhesion (GO:0090136)2.40514166
160glycoside metabolic process (GO:0016137)2.36060598
161regulation of cholesterol esterification (GO:0010872)2.34929259
162regulation of intracellular pH (GO:0051453)2.34345669
163decidualization (GO:0046697)2.33581482
164hydrogen peroxide biosynthetic process (GO:0050665)2.33434490
165urea cycle (GO:0000050)2.33380075
166keratan sulfate catabolic process (GO:0042340)2.32588368
167urea metabolic process (GO:0019627)2.32031553
168glycosylceramide metabolic process (GO:0006677)2.31576978
169negative regulation of nitric oxide biosynthetic process (GO:0045019)2.31530757
170cellular response to type I interferon (GO:0071357)2.29826413
171type I interferon signaling pathway (GO:0060337)2.29826413
172T-helper 1 type immune response (GO:0042088)2.29400474
173regulation of cellular extravasation (GO:0002691)2.29345360
174positive regulation of triglyceride lipase activity (GO:0061365)2.28731913
175positive regulation of lipoprotein lipase activity (GO:0051006)2.28731913
176response to laminar fluid shear stress (GO:0034616)2.27532337
177neutrophil activation involved in immune response (GO:0002283)2.27253366
178response to type I interferon (GO:0034340)2.27125175
179positive regulation of leukocyte degranulation (GO:0043302)2.26665393
180regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.25967163
181response to acidic pH (GO:0010447)2.23945230
182positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.23925136
183regulation of cellular pH (GO:0030641)2.22856887
184positive regulation of heat generation (GO:0031652)2.21390418
185oligosaccharide biosynthetic process (GO:0009312)2.20496347
186NADH metabolic process (GO:0006734)2.20397250
187establishment of skin barrier (GO:0061436)10.7396899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.54570216
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.30663215
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.42757168
4RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.11705502
5* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.96650499
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.91555759
7* ESR1_21235772_ChIP-Seq_MCF-7_Human2.91085852
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.88116266
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.68583322
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.62342412
11SOX2_27498859_Chip-Seq_STOMACH_Mouse2.61876366
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.54968372
13SOX2_20726797_ChIP-Seq_SW620_Human2.51831726
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.47664472
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36292596
16* ESR2_21235772_ChIP-Seq_MCF-7_Human2.36277495
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.32826044
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.31267464
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.29856421
20FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.29772303
21ZNF217_24962896_ChIP-Seq_MCF-7_Human2.20826132
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.18196385
23P63_26484246_Chip-Seq_KERATINOCYTES_Human2.17830716
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15062657
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10472323
26CDX2_20551321_ChIP-Seq_CACO-2_Human2.06413024
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03019709
28SOX9_24532713_ChIP-Seq_HFSC_Mouse2.02371875
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.99957761
30* GATA4_25053715_ChIP-Seq_YYC3_Human1.95099126
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.92111921
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87299821
33AHR_22903824_ChIP-Seq_MCF-7_Human1.81202616
34* LXR_22292898_ChIP-Seq_THP-1_Human1.80508170
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.79364062
36BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.77522975
37IGF1R_20145208_ChIP-Seq_DFB_Human1.71894135
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.71767477
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63951936
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.59705194
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58478531
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57251747
43GATA6_25053715_ChIP-Seq_YYC3_Human1.56506195
44* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55659962
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53097041
46SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51835337
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51835337
48KLF5_25053715_ChIP-Seq_YYC3_Human1.51477731
49GATA3_24758297_ChIP-Seq_MCF-7_Human1.46737972
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.42752408
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.42388285
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.41358243
53FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.41193001
54VDR_24763502_ChIP-Seq_THP-1_Human1.39484611
55FOXA1_25552417_ChIP-Seq_VCAP_Human1.39303729
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39281245
57FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38538773
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36749565
59* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34914149
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32723305
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30614148
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29207761
63VDR_24787735_ChIP-Seq_THP-1_Human1.28548872
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27506657
65VDR_22108803_ChIP-Seq_LS180_Human1.27109555
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26877157
67* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26773795
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.23762671
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23710266
70RACK7_27058665_Chip-Seq_MCF-7_Human1.23613887
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22042903
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21739818
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19399074
74* EZH2_27294783_Chip-Seq_ESCs_Mouse1.17926452
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17873104
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16485264
77TP63_23658742_ChIP-Seq_EP156T_Human1.15692644
78STAT1_20625510_ChIP-Seq_HELA_Human1.15199912
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12597926
80BCAT_22108803_ChIP-Seq_LS180_Human1.12142139
81VDR_21846776_ChIP-Seq_THP-1_Human1.12109090
82* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12032716
83* TP53_18474530_ChIP-ChIP_U2OS_Human1.10426005
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.10049412
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08850742
86EZH2_22144423_ChIP-Seq_EOC_Human1.08780945
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.08378259
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07489936
89ATF3_27146783_Chip-Seq_COLON_Human1.06935341
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05862353
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05606361
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04049363
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03909564
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03772004
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02693911
96* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02521081
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.01915077
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01173191
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00950042
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00399512
101PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00152428
102SPI1_23127762_ChIP-Seq_K562_Human0.99698871
103RUNX1_22412390_ChIP-Seq_EML_Mouse0.97320658
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97115992
105LXR_22158963_ChIP-Seq_LIVER_Mouse0.96496343
106DROSHA_22980978_ChIP-Seq_HELA_Human0.96346980
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95578181
108* EED_16625203_ChIP-ChIP_MESCs_Mouse0.95365234
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94386799
110* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94187894
111* GATA1_19941826_ChIP-Seq_K562_Human0.94118527
112E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93938203
113SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93258627
114CJUN_26792858_Chip-Seq_BT549_Human0.92976469
115* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92685479
116AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91107773
117* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90452206
118CLOCK_20551151_ChIP-Seq_293T_Human0.89991080
119BCOR_27268052_Chip-Seq_Bcells_Human0.89979550
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89377013
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89343094
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89217344
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88877651
124IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88762856
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88684775
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88198776
127* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.87558615
128* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.87558615
129* CDX2_22108803_ChIP-Seq_LS180_Human0.87238345
130* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86961878
131WT1_19549856_ChIP-ChIP_CCG9911_Human0.86111839
132RNF2_27304074_Chip-Seq_ESCs_Mouse0.86027593
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85452639
134EZH2_27304074_Chip-Seq_ESCs_Mouse0.85076500
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83464608
136TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83006073
137RXR_22108803_ChIP-Seq_LS180_Human0.82541608
138ZNF263_19887448_ChIP-Seq_K562_Human0.80851361
139* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77844407
140* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76192475
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.76060733
142SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75649623
143NANOG_20526341_ChIP-Seq_ESCs_Human0.75039972
144* TP63_22573176_ChIP-Seq_HFKS_Human0.73779884
145WT1_25993318_ChIP-Seq_PODOCYTE_Human0.73282999
146* CEBPB_22108803_ChIP-Seq_LS180_Human0.72067631
147* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.71895765
148CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.71601017
149STAT6_21828071_ChIP-Seq_BEAS2B_Human0.70443125
150NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.69672803
151HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69291248
152AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.69175667
153* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.68883955
154CTCF_27219007_Chip-Seq_Bcells_Human0.68802477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.01777377
2MP0002796_impaired_skin_barrier6.43661103
3MP0002139_abnormal_hepatobiliary_system5.37619862
4MP0003941_abnormal_skin_development4.59255184
5MP0005451_abnormal_body_composition4.00987927
6MP0005275_abnormal_skin_tensile3.97105092
7MP0009840_abnormal_foam_cell3.81091544
8MP0005501_abnormal_skin_physiology3.61864925
9MP0005058_abnormal_lysosome_morphology3.35267544
10MP0003878_abnormal_ear_physiology3.32495695
11MP0005377_hearing/vestibular/ear_phenot3.32495695
12MP0003303_peritoneal_inflammation3.09794756
13MP0008789_abnormal_olfactory_epithelium2.82325814
14MP0002060_abnormal_skin_morphology2.79734595
15MP0005365_abnormal_bile_salt2.69687033
16MP0006082_CNS_inflammation2.61606893
17MP0005499_abnormal_olfactory_system2.49113555
18MP0005394_taste/olfaction_phenotype2.49113555
19MP0004264_abnormal_extraembryonic_tissu2.48399935
20MP0002009_preneoplasia2.48025065
21MP0004381_abnormal_hair_follicle2.39841527
22MP0001216_abnormal_epidermal_layer2.27458203
23MP0003724_increased_susceptibility_to2.26879307
24MP0010678_abnormal_skin_adnexa2.18178127
25MP0010771_integument_phenotype2.15618717
26MP0002148_abnormal_hypersensitivity_rea2.15423136
27MP0009785_altered_susceptibility_to2.15422818
28MP0001984_abnormal_olfaction2.09581607
29MP0004947_skin_inflammation2.06706402
30MP0002098_abnormal_vibrissa_morphology2.00338305
31MP0003191_abnormal_cellular_cholesterol1.96524438
32MP0000647_abnormal_sebaceous_gland1.96207789
33MP0003436_decreased_susceptibility_to1.92697876
34MP0004782_abnormal_surfactant_physiolog1.87532121
35MP0000604_amyloidosis1.86859808
36MP0003453_abnormal_keratinocyte_physiol1.83580488
37MP0002877_abnormal_melanocyte_morpholog1.81514945
38MP0010030_abnormal_orbit_morphology1.72267087
39MP0000343_altered_response_to1.63335451
40MP0002277_abnormal_respiratory_mucosa1.61034081
41MP0002419_abnormal_innate_immunity1.60986029
42MP0001790_abnormal_immune_system1.58141001
43MP0005387_immune_system_phenotype1.58141001
44MP0005025_abnormal_response_to1.56981888
45MP0000377_abnormal_hair_follicle1.56401087
46MP0001533_abnormal_skeleton_physiology1.55846227
47MP0001485_abnormal_pinna_reflex1.55700869
48MP0005166_decreased_susceptibility_to1.53624430
49MP0003075_altered_response_to1.51207767
50MP0005257_abnormal_intraocular_pressure1.50865400
51MP0004510_myositis1.50826361
52MP0003172_abnormal_lysosome_physiology1.50377525
53MP0003806_abnormal_nucleotide_metabolis1.50144782
54MP0001835_abnormal_antigen_presentation1.50100931
55MP0002998_abnormal_bone_remodeling1.48457521
56MP0000427_abnormal_hair_cycle1.46583876
57MP0009764_decreased_sensitivity_to1.41660427
58MP0001845_abnormal_inflammatory_respons1.38073743
59MP0005310_abnormal_salivary_gland1.31613712
60MP0001666_abnormal_nutrient_absorption1.26996972
61MP0005165_increased_susceptibility_to1.26092467
62MP0000537_abnormal_urethra_morphology1.25791496
63MP0001873_stomach_inflammation1.25430296
64MP0000462_abnormal_digestive_system1.24946313
65MP0003705_abnormal_hypodermis_morpholog1.24065513
66MP0005000_abnormal_immune_tolerance1.23128446
67MP0003183_abnormal_peptide_metabolism1.22611913
68MP0008469_abnormal_protein_level1.19328511
69MP0000762_abnormal_tongue_morphology1.18367996
70MP0002254_reproductive_system_inflammat1.18056069
71MP0003879_abnormal_hair_cell1.17046730
72MP0000858_altered_metastatic_potential1.16593867
73MP0002452_abnormal_antigen_presenting1.15990365
74MP0009931_abnormal_skin_appearance1.13997307
75MP0003448_altered_tumor_morphology1.12680026
76MP0002233_abnormal_nose_morphology1.11108793
77MP0005023_abnormal_wound_healing1.10590947
78MP0010155_abnormal_intestine_physiology1.09114421
79MP0003329_amyloid_beta_deposits1.06032577
80MP0005645_abnormal_hypothalamus_physiol1.03439196
81MP0003300_gastrointestinal_ulcer1.03368708
82MP0004742_abnormal_vestibular_system1.03265845
83MP0003866_abnormal_defecation1.02472912
84MP0003868_abnormal_feces_composition0.98222911
85MP0000467_abnormal_esophagus_morphology0.98176208
86MP0009643_abnormal_urine_homeostasis0.98025286
87MP0001191_abnormal_skin_condition0.97365974
88MP0009780_abnormal_chondrocyte_physiolo0.96736336
89MP0005360_urolithiasis0.96546388
90MP0005164_abnormal_response_to0.94643647
91MP0000579_abnormal_nail_morphology0.93811889
92MP0005367_renal/urinary_system_phenotyp0.93417558
93MP0000516_abnormal_urinary_system0.93417558
94MP0001849_ear_inflammation0.93359381
95MP0000003_abnormal_adipose_tissue0.93182143
96MP0001346_abnormal_lacrimal_gland0.92845823
97MP0002723_abnormal_immune_serum0.92078448
98MP0005187_abnormal_penis_morphology0.91312475
99MP0000609_abnormal_liver_physiology0.90964852
100MP0009333_abnormal_splenocyte_physiolog0.90891957
101MP0001853_heart_inflammation0.90414592
102MP0000685_abnormal_immune_system0.90383763
103MP0003690_abnormal_glial_cell0.89793276
104MP0005671_abnormal_response_to0.86693065
105MP0002136_abnormal_kidney_physiology0.85672085
106MP0001800_abnormal_humoral_immune0.85653019
107MP0005319_abnormal_enzyme/_coenzyme0.84258662
108MP0008004_abnormal_stomach_pH0.83554408
109MP0009278_abnormal_bone_marrow0.83459738
110MP0004885_abnormal_endolymph0.81784307
111MP0002118_abnormal_lipid_homeostasis0.81705697
112MP0005666_abnormal_adipose_tissue0.81197442
113MP0000566_synostosis0.81068761
114MP0003091_abnormal_cell_migration0.81027548
115MP0000372_irregular_coat_pigmentation0.79854035
116MP0000477_abnormal_intestine_morphology0.79696812
117MP0000490_abnormal_crypts_of0.79577109
118MP0005636_abnormal_mineral_homeostasis0.79076724
119MP0000613_abnormal_salivary_gland0.78781964
120MP0005390_skeleton_phenotype0.78605636
121MP0005670_abnormal_white_adipose0.78154475
122MP0004185_abnormal_adipocyte_glucose0.77794364
123MP0008875_abnormal_xenobiotic_pharmacok0.77714604
124MP0003252_abnormal_bile_duct0.77571939
125MP0005464_abnormal_platelet_physiology0.76215902
126MP0005085_abnormal_gallbladder_physiolo0.76214932
127MP0000026_abnormal_inner_ear0.75507887
128MP0001819_abnormal_immune_cell0.75382962
129MP0003195_calcinosis0.75248941
130MP0002420_abnormal_adaptive_immunity0.74531792
131MP0000383_abnormal_hair_follicle0.73405656
132MP0003315_abnormal_perineum_morphology0.73255529
133MP0000049_abnormal_middle_ear0.73114212
134MP0002896_abnormal_bone_mineralization0.73102419
135MP0002132_abnormal_respiratory_system0.72826908
136MP0003795_abnormal_bone_structure0.72673966
137MP0005332_abnormal_amino_acid0.72186543
138MP0006072_abnormal_retinal_apoptosis0.68570441
139MP0005381_digestive/alimentary_phenotyp0.68310061
140MP0001542_abnormal_bone_strength0.67884741
141MP0001663_abnormal_digestive_system0.67831087
142MP0010386_abnormal_urinary_bladder0.67623309
143MP0002249_abnormal_larynx_morphology0.67397164
144MP0001243_abnormal_dermal_layer0.67376936
145MP0001963_abnormal_hearing_physiology0.66848949
146MP0001664_abnormal_digestion0.66675725
147MP0000470_abnormal_stomach_morphology0.65534197
148MP0006054_spinal_hemorrhage0.65412817
149MP0000367_abnormal_coat/_hair0.65130546
150MP0001944_abnormal_pancreas_morphology0.64854697
151MP0005375_adipose_tissue_phenotype0.64502930
152MP0004043_abnormal_pH_regulation0.64449814
153MP0004019_abnormal_vitamin_homeostasis0.63039676
154MP0005248_abnormal_Harderian_gland0.62715448
155MP0000538_abnormal_urinary_bladder0.62713595
156MP0001765_abnormal_ion_homeostasis0.62376808
157MP0001177_atelectasis0.60304605
158MP0002138_abnormal_hepatobiliary_system0.60105993
159MP0000013_abnormal_adipose_tissue0.59818727
160MP0010352_gastrointestinal_tract_polyps0.58112809
161MP0002166_altered_tumor_susceptibility0.57771154
162MP0003787_abnormal_imprinting0.55306270
163MP0005076_abnormal_cell_differentiation0.54781319
164MP0005220_abnormal_exocrine_pancreas0.54690047

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.77957872
2Congenital ichthyosiform erythroderma (HP:0007431)6.67953649
3Abnormality of glycolipid metabolism (HP:0010969)6.29808224
4Abnormality of liposaccharide metabolism (HP:0010968)6.29808224
5Abnormality of glycosphingolipid metabolism (HP:0004343)6.29808224
6Increased IgE level (HP:0003212)6.08739996
7Onycholysis (HP:0001806)5.72768584
8Systemic lupus erythematosus (HP:0002725)5.03853068
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.02271599
10Lip pit (HP:0100267)4.58337907
11Curly hair (HP:0002212)4.44943222
12Pustule (HP:0200039)4.25605408
13Woolly hair (HP:0002224)4.15486621
14Hypotrichosis (HP:0001006)4.12124914
15Dysostosis multiplex (HP:0000943)4.02002678
16Increased cerebral lipofuscin (HP:0011813)3.76439786
17Thin bony cortex (HP:0002753)3.75412346
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.66349428
19Widely patent fontanelles and sutures (HP:0004492)3.61443914
20Abnormality of nail color (HP:0100643)3.60035949
21Plantar hyperkeratosis (HP:0007556)3.59319828
22Abnormality of polysaccharide metabolism (HP:0011012)3.53335068
23Abnormality of glycosaminoglycan metabolism (HP:0004371)3.53335068
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.53335068
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.53285122
26Chronic bronchitis (HP:0004469)3.52460397
27Corneal erosion (HP:0200020)3.51693241
28Loss of speech (HP:0002371)3.51500481
29Dehydration (HP:0001944)3.48678855
30Malnutrition (HP:0004395)3.47889690
31Mucopolysacchariduria (HP:0008155)3.45591017
32Urinary glycosaminoglycan excretion (HP:0003541)3.45591017
33Abnormality of the gastric mucosa (HP:0004295)3.44279885
34Abnormality of macrophages (HP:0004311)3.38237624
35Enlarged epiphyses (HP:0010580)3.35829311
36Fragile nails (HP:0001808)3.33598368
37Ectropion (HP:0000656)3.32167950
38Gangrene (HP:0100758)3.27808316
39Decreased circulating renin level (HP:0003351)3.15282829
40Erythroderma (HP:0001019)3.07362181
41Increased neuronal autofluorescent lipopigment (HP:0002074)3.04403567
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.02927080
43Glomerulonephritis (HP:0000099)3.01878294
44Delayed epiphyseal ossification (HP:0002663)3.01269222
45Complement deficiency (HP:0004431)3.01060824
46Palmoplantar hyperkeratosis (HP:0000972)2.95839216
47Abnormality of chloride homeostasis (HP:0011422)2.95224385
48Xanthomatosis (HP:0000991)2.93196293
49Pruritus (HP:0000989)2.91881688
50Hydroxyprolinuria (HP:0003080)2.89967608
51Abnormality of proline metabolism (HP:0010907)2.89967608
52Intrahepatic cholestasis (HP:0001406)2.85830883
53Parakeratosis (HP:0001036)2.81949805
54Disinhibition (HP:0000734)2.81703224
55Abnormality of complement system (HP:0005339)2.77806509
56Palpitations (HP:0001962)2.77391312
57Palmar hyperkeratosis (HP:0010765)2.75500786
58Axonal loss (HP:0003447)2.74470184
59Hypohidrosis (HP:0000966)2.72887451
60Myocardial infarction (HP:0001658)2.72714558
61Abnormality of small intestinal villus morphology (HP:0011472)2.70439740
62Villous atrophy (HP:0011473)2.70439740
63Ileus (HP:0002595)2.68142521
64Syncope (HP:0001279)2.67140211
65Congenital sensorineural hearing impairment (HP:0008527)2.65284241
66Alopecia of scalp (HP:0002293)2.63382829
67Abnormality of the nasal mucosa (HP:0000433)2.61427967
68Potter facies (HP:0002009)2.57737162
69Facial shape deformation (HP:0011334)2.57737162
70Flat acetabular roof (HP:0003180)2.57645504
71Neurofibrillary tangles (HP:0002185)2.57058727
72Abnormality of the costochondral junction (HP:0000919)2.56484237
73Nuclear cataract (HP:0100018)2.56478806
74Recurrent abscess formation (HP:0002722)2.52630249
75Hyperactive renin-angiotensin system (HP:0000841)2.51269550
76Fat malabsorption (HP:0002630)2.47878230
77Recurrent bacterial skin infections (HP:0005406)2.47405911
78Ventricular tachycardia (HP:0004756)2.44511689
79Recurrent gram-negative bacterial infections (HP:0005420)2.44447323
80Progressive hearing impairment (HP:0001730)2.42337038
81Acanthosis nigricans (HP:0000956)2.40538307
82Abnormality of the distal phalanges of the toes (HP:0010182)2.37205846
83Abdominal distention (HP:0003270)2.32241799
84Eczematoid dermatitis (HP:0000976)2.30875463
85Metaphyseal irregularity (HP:0003025)2.29455437
86Popliteal pterygium (HP:0009756)2.28905090
87Bone pain (HP:0002653)2.27163372
88Milia (HP:0001056)2.23674623
89Protuberant abdomen (HP:0001538)2.23326975
90Rectal prolapse (HP:0002035)2.22786916
91Amyloidosis (HP:0011034)2.21406524
92Autoimmune thrombocytopenia (HP:0001973)2.18196243
93Wide cranial sutures (HP:0010537)2.18115359
94Hypothermia (HP:0002045)2.18091056
95Prolonged neonatal jaundice (HP:0006579)2.17807070
96Mutism (HP:0002300)2.17096549
97Metabolic alkalosis (HP:0200114)2.16669026
98Vertebral compression fractures (HP:0002953)2.16501865
99Cheilitis (HP:0100825)2.15967724
100Ventricular fibrillation (HP:0001663)2.15633014
101Pili torti (HP:0003777)2.15114190
102Rickets (HP:0002748)2.14378607
103Palmoplantar keratoderma (HP:0000982)2.14155393
104Hemorrhage of the eye (HP:0011885)2.12590345
105Nasal polyposis (HP:0100582)2.10701169
106Erythema (HP:0010783)2.10657236
107Distal lower limb muscle weakness (HP:0009053)2.10200700
108Hyperparathyroidism (HP:0000843)2.08398526
109Petechiae (HP:0000967)2.08203692
110Conjunctival hamartoma (HP:0100780)2.07477598
111Increased serum ferritin (HP:0003281)2.07132137
112Nephritis (HP:0000123)2.06499995
113Abnormality of renin-angiotensin system (HP:0000847)2.06494001
114Abnormal blistering of the skin (HP:0008066)2.05041660
115Steatorrhea (HP:0002570)2.05008903
116Hematochezia (HP:0002573)2.03112479
117Asthma (HP:0002099)2.02573001
118Oligodontia (HP:0000677)2.02499572
119Hyporeflexia of lower limbs (HP:0002600)2.02412493
120Abnormality of macular pigmentation (HP:0008002)2.01297819
121Purpura (HP:0000979)2.01158132
122Progressive neurologic deterioration (HP:0002344)2.00793772
123Abnormality of the vasculature of the conjunctiva (HP:0008054)1.99994465
124Hypoplasia of dental enamel (HP:0006297)1.99524187
125Dry skin (HP:0000958)1.98706658
126Skin nodule (HP:0200036)1.98683983
127Osteolytic defects of the hand bones (HP:0009699)1.97562392
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.97562392
129Alkalosis (HP:0001948)1.96183251
130Exocrine pancreatic insufficiency (HP:0001738)1.96069690
131Anhidrosis (HP:0000970)1.94985355
132Abnormal tarsal ossification (HP:0008369)1.93662701
133Hypoplasia of the uterus (HP:0000013)1.93613172
134Cardiomegaly (HP:0001640)1.93035490
135Atrophic scars (HP:0001075)1.92484516
136Orchitis (HP:0100796)1.91748071
137Azoospermia (HP:0000027)1.91575375
138Vascular calcification (HP:0004934)1.91240420
139Nausea (HP:0002018)1.90829998
140Asymmetric septal hypertrophy (HP:0001670)1.90763839
141Abnormal pancreas size (HP:0012094)1.90066870
142Concave nail (HP:0001598)1.89753752
143Hypokalemia (HP:0002900)1.89120971
144Hypoplastic labia majora (HP:0000059)1.88679664
145Multiple lipomas (HP:0001012)1.88117373
146Unilateral renal agenesis (HP:0000122)1.87932956
147Tetraparesis (HP:0002273)1.87516333
148Interstitial pulmonary disease (HP:0006530)1.86426175
149Xerostomia (HP:0000217)1.85167715
150Advanced eruption of teeth (HP:0006288)1.84346379
151Hyperaldosteronism (HP:0000859)1.84318786
152Absent eyebrow (HP:0002223)1.82820393
153Hepatosplenomegaly (HP:0001433)1.82535436
154Cerebral inclusion bodies (HP:0100314)1.82413739
155Increased CSF protein (HP:0002922)1.82235316
156Ovoid vertebral bodies (HP:0003300)1.81394117
157Aplasia/hypoplasia of the uterus (HP:0008684)1.81003876
158Thoracic kyphosis (HP:0002942)1.79613809
159Conjugated hyperbilirubinemia (HP:0002908)1.78132261
160Asymmetry of the thorax (HP:0001555)1.77917793
161Symphalangism affecting the phalanges of the hand (HP:0009773)1.77263351
162Vacuolated lymphocytes (HP:0001922)1.76470015
163Apathy (HP:0000741)1.75825857
164Abnormality of the right ventricle (HP:0001707)1.75240649
165Abnormality of cochlea (HP:0000375)1.73271537
166Hypophosphatemia (HP:0002148)1.72934055
167Sparse scalp hair (HP:0002209)1.72630692
168Hypotension (HP:0002615)1.72582524
169Abnormality of the 1st metacarpal (HP:0010009)1.72458070
170Gingivitis (HP:0000230)1.72254828
171Diminished motivation (HP:0000745)1.72179839
172Abnormality of placental membranes (HP:0011409)1.72080787
173Amniotic constriction ring (HP:0009775)1.72080787
174Sparse eyelashes (HP:0000653)1.71746392
175Severe Myopia (HP:0011003)1.71078152
176Septate vagina (HP:0001153)1.70646206
177Abnormality of the lumbar spine (HP:0100712)1.70526318
178Bone cyst (HP:0012062)1.70425804
179Premature loss of primary teeth (HP:0006323)1.70068992
180Short nail (HP:0001799)1.68169178
181Cervical subluxation (HP:0003308)1.66007183
182Pathologic fracture (HP:0002756)1.65755628
183Abnormality of iron homeostasis (HP:0011031)1.65311976

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK35.10945312
2MST44.21913538
3FRK3.82861350
4IRAK33.64740870
5ERBB33.29121530
6EEF2K3.21691480
7MST1R3.03645378
8LMTK22.92246910
9NME22.90652388
10RPS6KB22.90637961
11ACVR1B2.86618942
12EPHA22.83303539
13MAP3K22.76848798
14MAPKAPK52.41936457
15TRPM72.30634698
16TESK12.28657930
17STK242.07218279
18GRK72.04520714
19MAPK152.00106379
20BMPR21.93784066
21TYK21.91945371
22FER1.91193853
23MAP2K21.79119624
24PTK61.65708310
25ABL21.64457926
26DDR21.59065432
27EPHB21.55737456
28TAOK21.54455751
29PAK41.52167201
30TGFBR21.52164856
31INSRR1.45565909
32NUAK11.43826498
33TAOK11.41755515
34PRKG21.39142120
35CDC42BPA1.31676652
36DYRK1B1.31207464
37RIPK41.23302721
38CDK31.21472765
39CSK1.19674274
40AKT31.15864355
41MAP2K11.12125047
42MAP3K121.09868992
43FGR1.08624752
44PIK3CA1.08527000
45GRK11.07924025
46IKBKB1.06149151
47RIPK11.06117854
48SMG11.05242306
49PAK31.04864132
50TESK21.04246271
51IRAK11.02567223
52STK38L1.01409887
53MAP3K31.00341101
54PDK20.99892375
55PDGFRA0.98635280
56IRAK40.97038161
57NEK10.96657164
58NME10.96261151
59ZAP700.95348404
60LATS10.95320047
61MAPK130.94631866
62ERBB20.90746114
63ADRBK20.90015251
64CAMK2D0.89166081
65FGFR40.88764185
66LIMK10.87833847
67PIK3CG0.87612562
68SIK10.85340768
69BCR0.81505977
70SRPK10.79313217
71PDPK10.76643938
72JAK10.76478847
73PRKCI0.76363392
74HIPK20.74777789
75STK160.73683737
76MAP3K100.73516284
77ERN10.73292949
78PRKAA20.73208436
79DYRK30.72028733
80LATS20.69961349
81MAPKAPK20.69513121
82MAP3K70.64739897
83MAP3K90.63186905
84RPS6KA20.63073376
85PRKD30.62063777
86ICK0.60894524
87MAP2K30.60847930
88MAP3K10.59358638
89IKBKE0.58758331
90TRIB30.58635527
91MOS0.58497518
92IRAK20.57753385
93DAPK20.57490541
94PBK0.56573366
95EPHB10.56158433
96JAK30.55073304
97CSNK1A1L0.54951081
98CDK60.54082348
99ERBB40.54036351
100MAP3K140.53091846
101DMPK0.50794960
102CHUK0.50014369
103WNK10.49164683
104BLK0.48516492
105PRPF4B0.47985097
106MAP4K10.47746659
107WNK40.47472873
108NEK90.44178862
109CAMK2B0.42538361
110MYLK0.42453622
111MAP2K60.41023333
112BMX0.40562016
113PIM20.39773546
114YES10.39766848
115CSF1R0.39247302
116MAPK110.38403880
117MAP3K80.38163746
118MET0.38013442
119TBK10.37949008
120MELK0.37910263
121ARAF0.37469515
122PRKCE0.37192160
123MAP3K60.36321634
124PHKG20.36222990
125PHKG10.36222990
126RPS6KL10.35418729
127RPS6KC10.35418729
128STK390.34826792
129CDK90.34473624
130LYN0.34326563
131CAMKK20.33156417
132PDK10.31800723
133PRKCD0.31334070
134PDGFRB0.30817605
135CASK0.28863709
136JAK20.28846510
137MAP3K130.28343110
138DYRK20.28065694
139LRRK20.27962685
140CAMK2G0.27347938
141PTK20.27133596
142RPS6KA10.26836292
143EPHA30.26544727
144FGFR10.25804215
145MAP3K110.22708304
146ITK0.22620215
147BRAF0.21660182
148VRK10.21304572
149PRKCA0.20258715
150TAOK30.19601176
151STK100.19590805
152MATK0.19373146

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.34623317
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.94711260
3Linoleic acid metabolism_Homo sapiens_hsa005912.80681328
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.79434296
5Fat digestion and absorption_Homo sapiens_hsa049752.59064612
6Lysosome_Homo sapiens_hsa041422.58114412
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49810445
8Mineral absorption_Homo sapiens_hsa049782.23614223
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.14089401
10Phototransduction_Homo sapiens_hsa047442.13300944
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10127740
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08388983
13ABC transporters_Homo sapiens_hsa020102.06034706
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.05107913
15Arachidonic acid metabolism_Homo sapiens_hsa005902.04935247
16Staphylococcus aureus infection_Homo sapiens_hsa051502.01692812
17Sphingolipid metabolism_Homo sapiens_hsa006002.00403015
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.99676813
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.93259444
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.89129333
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88741232
22Olfactory transduction_Homo sapiens_hsa047401.72330290
23Caffeine metabolism_Homo sapiens_hsa002321.69890361
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69368087
25Histidine metabolism_Homo sapiens_hsa003401.67125303
26Rheumatoid arthritis_Homo sapiens_hsa053231.63108550
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.58259476
28Starch and sucrose metabolism_Homo sapiens_hsa005001.57775856
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57215504
30PPAR signaling pathway_Homo sapiens_hsa033201.56197094
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55696216
32Ether lipid metabolism_Homo sapiens_hsa005651.55619904
33* Tight junction_Homo sapiens_hsa045301.46352438
34Chemical carcinogenesis_Homo sapiens_hsa052041.45531117
35Pertussis_Homo sapiens_hsa051331.43453093
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41807810
37Vibrio cholerae infection_Homo sapiens_hsa051101.38785437
38Osteoclast differentiation_Homo sapiens_hsa043801.37971818
39Asthma_Homo sapiens_hsa053101.37607087
40Complement and coagulation cascades_Homo sapiens_hsa046101.34355151
41Allograft rejection_Homo sapiens_hsa053301.29323461
42Leishmaniasis_Homo sapiens_hsa051401.27771032
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.26427489
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.25605712
45Fatty acid degradation_Homo sapiens_hsa000711.21764710
46Tuberculosis_Homo sapiens_hsa051521.20410659
47Retinol metabolism_Homo sapiens_hsa008301.20201250
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.13281886
49Protein export_Homo sapiens_hsa030601.12909565
50Pancreatic secretion_Homo sapiens_hsa049721.12134558
51Glutathione metabolism_Homo sapiens_hsa004801.10923781
52Adherens junction_Homo sapiens_hsa045201.07681311
53Salmonella infection_Homo sapiens_hsa051321.03805328
54Folate biosynthesis_Homo sapiens_hsa007901.03541186
55Steroid biosynthesis_Homo sapiens_hsa001001.03459593
56Phagosome_Homo sapiens_hsa041451.01591028
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.00802331
58Tryptophan metabolism_Homo sapiens_hsa003800.99830603
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99552573
60Arginine biosynthesis_Homo sapiens_hsa002200.97910707
61Malaria_Homo sapiens_hsa051440.97561414
62Insulin secretion_Homo sapiens_hsa049110.97476566
63Autoimmune thyroid disease_Homo sapiens_hsa053200.97098275
64Legionellosis_Homo sapiens_hsa051340.95739181
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.95443020
66Graft-versus-host disease_Homo sapiens_hsa053320.95347763
67Renin-angiotensin system_Homo sapiens_hsa046140.93893362
68Influenza A_Homo sapiens_hsa051640.89440889
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89118661
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89014389
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88483300
72Tyrosine metabolism_Homo sapiens_hsa003500.87838842
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87714318
74Circadian rhythm_Homo sapiens_hsa047100.83408579
75Toxoplasmosis_Homo sapiens_hsa051450.82112516
76* Hepatitis C_Homo sapiens_hsa051600.80128529
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79999019
78Protein digestion and absorption_Homo sapiens_hsa049740.78338290
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74771515
80Antigen processing and presentation_Homo sapiens_hsa046120.74116195
81Prion diseases_Homo sapiens_hsa050200.72235121
82Thyroid hormone synthesis_Homo sapiens_hsa049180.71701797
83Type I diabetes mellitus_Homo sapiens_hsa049400.70802290
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69545990
85African trypanosomiasis_Homo sapiens_hsa051430.69436804
86Pentose phosphate pathway_Homo sapiens_hsa000300.68079400
87Butanoate metabolism_Homo sapiens_hsa006500.67337010
88Oxidative phosphorylation_Homo sapiens_hsa001900.67010909
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66915008
90Bladder cancer_Homo sapiens_hsa052190.66860333
91Bile secretion_Homo sapiens_hsa049760.66283229
92Amoebiasis_Homo sapiens_hsa051460.64890985
93Gastric acid secretion_Homo sapiens_hsa049710.64031143
94Other glycan degradation_Homo sapiens_hsa005110.63173877
95Nitrogen metabolism_Homo sapiens_hsa009100.62658042
96Collecting duct acid secretion_Homo sapiens_hsa049660.61473968
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61166668
98Alzheimers disease_Homo sapiens_hsa050100.59629285
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59607523
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56232156
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55554683
102GnRH signaling pathway_Homo sapiens_hsa049120.55497575
103* Leukocyte transendothelial migration_Homo sapiens_hsa046700.54735109
104Melanogenesis_Homo sapiens_hsa049160.54692011
105Galactose metabolism_Homo sapiens_hsa000520.54236075
106Prostate cancer_Homo sapiens_hsa052150.53519717
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53244289
108Amphetamine addiction_Homo sapiens_hsa050310.53155210
109Cocaine addiction_Homo sapiens_hsa050300.52378895
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52015342
111Serotonergic synapse_Homo sapiens_hsa047260.51369557
112Hematopoietic cell lineage_Homo sapiens_hsa046400.51159856
113Arginine and proline metabolism_Homo sapiens_hsa003300.50737787
114Taste transduction_Homo sapiens_hsa047420.50453269
115Glycerolipid metabolism_Homo sapiens_hsa005610.49939042
116Thyroid cancer_Homo sapiens_hsa052160.49372332
117Fatty acid elongation_Homo sapiens_hsa000620.48375769
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.48104131
119Apoptosis_Homo sapiens_hsa042100.47168074
120Alcoholism_Homo sapiens_hsa050340.46393667
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.46176693
122Peroxisome_Homo sapiens_hsa041460.45945665
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45569836
124Endometrial cancer_Homo sapiens_hsa052130.44505819
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43676634
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43025495
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42655111
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.42218934
129* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41770289
130Insulin resistance_Homo sapiens_hsa049310.41558431
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40780955
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40320434
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39718699
134Dopaminergic synapse_Homo sapiens_hsa047280.39317432
135ErbB signaling pathway_Homo sapiens_hsa040120.39133386
136Viral myocarditis_Homo sapiens_hsa054160.38492100
137Hippo signaling pathway_Homo sapiens_hsa043900.38003556
138Shigellosis_Homo sapiens_hsa051310.36825585
139beta-Alanine metabolism_Homo sapiens_hsa004100.36742583
140Chemokine signaling pathway_Homo sapiens_hsa040620.35830216
141Estrogen signaling pathway_Homo sapiens_hsa049150.35737956
142Type II diabetes mellitus_Homo sapiens_hsa049300.35308319
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34115453
144Cholinergic synapse_Homo sapiens_hsa047250.34004961
145Salivary secretion_Homo sapiens_hsa049700.33489361
146Basal cell carcinoma_Homo sapiens_hsa052170.32868340
147TNF signaling pathway_Homo sapiens_hsa046680.32578121
148Melanoma_Homo sapiens_hsa052180.32261941
149Glucagon signaling pathway_Homo sapiens_hsa049220.31801844
150Ras signaling pathway_Homo sapiens_hsa040140.31409187
151Fructose and mannose metabolism_Homo sapiens_hsa000510.30960426
152Vitamin digestion and absorption_Homo sapiens_hsa049770.30913562
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28857111
154FoxO signaling pathway_Homo sapiens_hsa040680.28165053
155cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26620390
156Prolactin signaling pathway_Homo sapiens_hsa049170.26010860
157Phenylalanine metabolism_Homo sapiens_hsa003600.25584225

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