CLDN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.82539989
2L-phenylalanine catabolic process (GO:0006559)6.82539989
3L-phenylalanine metabolic process (GO:0006558)6.71316146
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.71316146
5lysine catabolic process (GO:0006554)6.44526091
6lysine metabolic process (GO:0006553)6.44526091
7aromatic amino acid family catabolic process (GO:0009074)6.42163755
8glyoxylate metabolic process (GO:0046487)6.35951751
9cobalamin metabolic process (GO:0009235)6.29274544
10drug transmembrane transport (GO:0006855)6.27694386
11cysteine metabolic process (GO:0006534)6.26365328
12urate metabolic process (GO:0046415)6.20427229
13digestion (GO:0007586)6.11776888
14indole-containing compound catabolic process (GO:0042436)6.02243688
15indolalkylamine catabolic process (GO:0046218)6.02243688
16tryptophan catabolic process (GO:0006569)6.02243688
17tryptophan metabolic process (GO:0006568)5.67220201
18kynurenine metabolic process (GO:0070189)5.63802989
19maintenance of gastrointestinal epithelium (GO:0030277)5.47644897
20homocysteine metabolic process (GO:0050667)5.37924920
21drug transport (GO:0015893)5.29798885
22drug catabolic process (GO:0042737)5.22946444
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.18333369
24serine family amino acid catabolic process (GO:0009071)5.12188023
25sulfur amino acid catabolic process (GO:0000098)5.10097861
26bile acid biosynthetic process (GO:0006699)4.94369727
27amino-acid betaine metabolic process (GO:0006577)4.88760967
28sodium-independent organic anion transport (GO:0043252)4.83297759
29actin filament depolymerization (GO:0030042)4.80682019
30regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.74219100
31aromatic amino acid family metabolic process (GO:0009072)4.71737433
32urea metabolic process (GO:0019627)4.64386898
33urea cycle (GO:0000050)4.64386898
34alpha-linolenic acid metabolic process (GO:0036109)4.62591782
35intestinal absorption (GO:0050892)4.62509565
36cellular ketone body metabolic process (GO:0046950)4.59142095
37complement activation, classical pathway (GO:0006958)4.57700097
38exogenous drug catabolic process (GO:0042738)4.57458212
39short-chain fatty acid metabolic process (GO:0046459)4.53985423
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.53523084
41serine family amino acid metabolic process (GO:0009069)4.53154604
42aspartate family amino acid catabolic process (GO:0009068)4.49756563
43cellular modified amino acid catabolic process (GO:0042219)4.47062915
44cellular response to hepatocyte growth factor stimulus (GO:0035729)4.44898933
45response to hepatocyte growth factor (GO:0035728)4.44898933
46alpha-amino acid catabolic process (GO:1901606)4.42691722
47glutamate metabolic process (GO:0006536)4.41194198
48nitrogen cycle metabolic process (GO:0071941)4.30858914
49acute-phase response (GO:0006953)4.27697119
50bile acid metabolic process (GO:0008206)4.26987470
51response to mercury ion (GO:0046689)4.26886328
52phosphate ion transport (GO:0006817)4.24629894
53cellular amino acid catabolic process (GO:0009063)4.23834964
54indolalkylamine metabolic process (GO:0006586)4.23588094
55regulation of cellular extravasation (GO:0002691)4.16456180
56* calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.13261063
57intestinal cholesterol absorption (GO:0030299)4.12309513
58epithelial structure maintenance (GO:0010669)4.09734274
59benzene-containing compound metabolic process (GO:0042537)4.08228526
60organic cation transport (GO:0015695)4.07776638
61serine family amino acid biosynthetic process (GO:0009070)4.07635498
62daunorubicin metabolic process (GO:0044597)4.07370729
63polyketide metabolic process (GO:0030638)4.07370729
64doxorubicin metabolic process (GO:0044598)4.07370729
65acetyl-CoA metabolic process (GO:0006084)4.05782080
662-oxoglutarate metabolic process (GO:0006103)4.05676674
67cellular biogenic amine catabolic process (GO:0042402)4.02966903
68amine catabolic process (GO:0009310)4.02966903
69phosphate ion transmembrane transport (GO:0035435)4.02517664
70lung vasculature development (GO:0060426)4.01856503
71cellular glucuronidation (GO:0052695)4.01116910
72regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.99715638
73opsonization (GO:0008228)3.98823305
74tyrosine metabolic process (GO:0006570)3.98419188
75fatty acid beta-oxidation (GO:0006635)3.97712962
76ketone body metabolic process (GO:1902224)3.96272913
77peptide catabolic process (GO:0043171)3.95431921
78regulation of cholesterol homeostasis (GO:2000188)3.93546523
79transepithelial transport (GO:0070633)3.92567152
80epoxygenase P450 pathway (GO:0019373)3.89873418
81fatty acid oxidation (GO:0019395)3.88629033
82complement activation (GO:0006956)3.88162629
83carnitine metabolic process (GO:0009437)3.88058918
84high-density lipoprotein particle remodeling (GO:0034375)3.87599251
85fatty acid derivative transport (GO:1901571)3.87131014
86icosanoid transport (GO:0071715)3.87131014
87regulation of apoptotic process involved in morphogenesis (GO:1902337)3.85921537
88regulation of apoptotic cell clearance (GO:2000425)3.85319472
89negative regulation of sterol transport (GO:0032372)3.83510146
90negative regulation of cholesterol transport (GO:0032375)3.83510146
91peptidyl-glutamic acid carboxylation (GO:0017187)3.83125712
92protein carboxylation (GO:0018214)3.83125712
93lipid oxidation (GO:0034440)3.80819767
94angiotensin maturation (GO:0002003)3.80120851
95complement activation, alternative pathway (GO:0006957)3.79455635
96negative regulation of fibrinolysis (GO:0051918)3.79168894
97aldehyde catabolic process (GO:0046185)3.79128159
98glycine metabolic process (GO:0006544)3.78946299
99ethanol oxidation (GO:0006069)3.78687775
100glucuronate metabolic process (GO:0019585)3.78661981
101uronic acid metabolic process (GO:0006063)3.78661981
102organic acid catabolic process (GO:0016054)3.78349005
103carboxylic acid catabolic process (GO:0046395)3.78349005
104bile acid and bile salt transport (GO:0015721)3.78001137
105acute inflammatory response (GO:0002526)3.77073734
106valine metabolic process (GO:0006573)3.73057449
107flavonoid metabolic process (GO:0009812)3.72686899
108regulation of protein activation cascade (GO:2000257)3.71518097
109regulation of triglyceride catabolic process (GO:0010896)3.71404078
110dicarboxylic acid biosynthetic process (GO:0043650)3.71140498
111quaternary ammonium group transport (GO:0015697)3.67576202
112regulation of bile acid biosynthetic process (GO:0070857)3.67491099
113triglyceride homeostasis (GO:0070328)3.67481390
114acylglycerol homeostasis (GO:0055090)3.67481390
115reverse cholesterol transport (GO:0043691)3.64691631
116positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.64411262
117regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.64411262
118vitamin D metabolic process (GO:0042359)3.63331893
119fatty acid catabolic process (GO:0009062)3.61824207
120monocarboxylic acid catabolic process (GO:0072329)3.61289412
121tricarboxylic acid metabolic process (GO:0072350)3.61010326
122drug metabolic process (GO:0017144)3.59321400
123fructose metabolic process (GO:0006000)3.55266086
124regulation of fibrinolysis (GO:0051917)3.54895291
125coenzyme catabolic process (GO:0009109)3.54763072
126regulation of interleukin-8 secretion (GO:2000482)3.53829327
127primary alcohol catabolic process (GO:0034310)3.53621119
128branched-chain amino acid metabolic process (GO:0009081)3.52827183
129regulation of cholesterol esterification (GO:0010872)3.52650094
130aminoglycoside antibiotic metabolic process (GO:0030647)3.51178889
131positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.48284986
132regulation of complement activation (GO:0030449)3.46769100
133response to nitrosative stress (GO:0051409)3.45178335
134auditory receptor cell differentiation (GO:0042491)3.44561817
135regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.38637986
136protein-lipid complex remodeling (GO:0034368)3.38354836
137macromolecular complex remodeling (GO:0034367)3.38354836
138plasma lipoprotein particle remodeling (GO:0034369)3.38354836
139renal absorption (GO:0070293)3.35514748
140regulation of transforming growth factor beta1 production (GO:0032908)3.29907774
141excretion (GO:0007588)3.29710138
142protein activation cascade (GO:0072376)3.28826558
143bundle of His cell to Purkinje myocyte communication (GO:0086069)3.25504913
144lung lobe morphogenesis (GO:0060463)3.17225668
145renal filtration (GO:0097205)3.07150752
146antibacterial humoral response (GO:0019731)3.00118995
147digestive system process (GO:0022600)2.97809367
148regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.95817061
149regulation of macrophage chemotaxis (GO:0010758)2.93187526
150glomerular filtration (GO:0003094)2.92002388
151glycoside metabolic process (GO:0016137)2.91587901
152glutathione biosynthetic process (GO:0006750)2.91048613
153antimicrobial humoral response (GO:0019730)2.86377939
154cholesterol homeostasis (GO:0042632)2.86191709
155desmosome organization (GO:0002934)2.85230651
156negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.84073449
157regulation of metalloenzyme activity (GO:0048552)2.83487393
158hormone catabolic process (GO:0042447)2.82353807
159sterol homeostasis (GO:0055092)2.81870963
160positive regulation of respiratory burst (GO:0060267)2.79349753
161L-ascorbic acid metabolic process (GO:0019852)2.78295284
162nonribosomal peptide biosynthetic process (GO:0019184)2.77741091
163nephron tubule formation (GO:0072079)2.76382308
164positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.75929125
165negative regulation of leukocyte chemotaxis (GO:0002689)2.75350728
166thyroid hormone generation (GO:0006590)2.74595491
167phenylpropanoid metabolic process (GO:0009698)2.74329452
168O-glycan processing (GO:0016266)2.73975215
169toxin transport (GO:1901998)2.73151914
170positive regulation of metanephros development (GO:0072216)2.71524415
171cellular response to vitamin D (GO:0071305)2.71407793
172positive regulation of glomerulus development (GO:0090193)2.70532973
173ethanol metabolic process (GO:0006067)2.70153046
174hydrogen peroxide metabolic process (GO:0042743)2.60208626
175metanephric nephron epithelium development (GO:0072243)2.59301369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.60023633
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.64575373
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.89780042
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.58308670
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.87737157
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.24472519
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.90310786
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.63149504
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.18098041
10* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.68295283
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.38483838
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.32686993
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31879400
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27038010
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10922698
16CLOCK_20551151_ChIP-Seq_293T_Human2.07580900
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4348208
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.84125373
19SOX2_27498859_Chip-Seq_STOMACH_Mouse1.83236525
20CDX2_20551321_ChIP-Seq_CACO-2_Human1.78537362
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.72185214
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70394119
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.66242370
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64977642
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64797371
26GATA4_25053715_ChIP-Seq_YYC3_Human1.64621261
27HNF4A_19822575_ChIP-Seq_HepG2_Human1.63340215
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.59012166
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51953831
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.49216749
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44899338
32AHR_22903824_ChIP-Seq_MCF-7_Human1.32248603
33ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31530026
34* CJUN_26792858_Chip-Seq_BT549_Human1.29720788
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26238697
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.24005194
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.22616403
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.22593008
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.20915925
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17805759
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17805759
42* GATA6_25053715_ChIP-Seq_YYC3_Human1.16659036
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14542509
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.13514681
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.12525637
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11491374
47* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10480435
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09594668
49AR_21909140_ChIP-Seq_LNCAP_Human1.08562759
50GATA1_22025678_ChIP-Seq_K562_Human1.07872233
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07439789
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03407445
53* SOX2_20726797_ChIP-Seq_SW620_Human1.03212985
54KLF5_25053715_ChIP-Seq_YYC3_Human0.99700977
55PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99036655
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97559913
57NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95958465
58ARNT_22903824_ChIP-Seq_MCF-7_Human0.95713258
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95508190
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94846575
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94672772
62SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94639547
63SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90299938
64RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89450590
65ZNF263_19887448_ChIP-Seq_K562_Human0.88476348
66SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88006398
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86867550
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86835540
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86059649
70STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85694666
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84474892
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83281696
73ESR1_20079471_ChIP-ChIP_T-47D_Human0.82687140
74LXR_22292898_ChIP-Seq_THP-1_Human0.82059214
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81843839
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81801859
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81210224
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81051650
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.80646714
80FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80604993
81EGR1_19032775_ChIP-ChIP_M12_Human0.79330917
82RACK7_27058665_Chip-Seq_MCF-7_Human0.78921743
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77591601
84CTCF_27219007_Chip-Seq_Bcells_Human0.76886101
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76620508
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76439257
87SMAD3_21741376_ChIP-Seq_HESCs_Human0.76373523
88NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75927039
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75927039
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.74046476
91ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73595544
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73261114
93FOXM1_26456572_ChIP-Seq_MCF-7_Human0.72913372
94HTT_18923047_ChIP-ChIP_STHdh_Human0.72691085
95TP53_18474530_ChIP-ChIP_U2OS_Human0.72263402
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.70464517
97HIF1A_21447827_ChIP-Seq_MCF-7_Human0.70405180
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.70145131
99RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68795230
100TP53_16413492_ChIP-PET_HCT116_Human0.68369256
101PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.67802556
102P300_27058665_Chip-Seq_ZR-75-30cells_Human0.66797179
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.66258706
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.65567061
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.65557575
106BCOR_27268052_Chip-Seq_Bcells_Human0.65438699
107FOXA1_25552417_ChIP-Seq_VCAP_Human0.65316861
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.64968610
109GATA3_24758297_ChIP-Seq_MCF-7_Human0.64735474
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.63964750
111AUTS2_25519132_ChIP-Seq_293T-REX_Human0.63377148
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62753691
113MYC_19915707_ChIP-ChIP_AK7_Human0.61947008
114GATA2_19941826_ChIP-Seq_K562_Human0.61619752
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.61369280
116CDX2_22108803_ChIP-Seq_LS180_Human0.61342450
117KAP1_22055183_ChIP-Seq_ESCs_Mouse0.61171468
118CEBPB_22108803_ChIP-Seq_LS180_Human0.60641233
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.60409287
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60129103
121AR_20517297_ChIP-Seq_VCAP_Human0.59824956
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.58646417
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.58432675
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.58218479
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.56639620
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.56555136
127IRF8_22096565_ChIP-ChIP_GC-B_Human0.56385212
128ATF3_27146783_Chip-Seq_COLON_Human0.56015875
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55482426
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.52030276
131SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.51824022
132CBP_21632823_ChIP-Seq_H3396_Human0.51228479
133TBX20_22080862_ChIP-Seq_HEART_Mouse0.50166347
134TBX20_22328084_ChIP-Seq_HEART_Mouse0.50166347
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.49671521
136* STAT1_17558387_ChIP-Seq_HELA_Human0.49372457
137TP63_23658742_ChIP-Seq_EP156T_Human0.48527604
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.47647749
139P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.47644891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.36396517
2MP0002139_abnormal_hepatobiliary_system7.43270781
3MP0005085_abnormal_gallbladder_physiolo5.26952768
4MP0005365_abnormal_bile_salt5.08201910
5MP0008875_abnormal_xenobiotic_pharmacok4.46002670
6MP0003252_abnormal_bile_duct3.90032924
7MP0005332_abnormal_amino_acid3.68634615
8MP0004019_abnormal_vitamin_homeostasis3.64660809
9MP0003195_calcinosis3.44677184
10MP0003806_abnormal_nucleotide_metabolis3.19488144
11MP0002138_abnormal_hepatobiliary_system3.10777860
12MP0010386_abnormal_urinary_bladder2.93820837
13MP0010329_abnormal_lipoprotein_level2.73060379
14MP0005409_darkened_coat_color2.71161776
15MP0004043_abnormal_pH_regulation2.65959364
16MP0001666_abnormal_nutrient_absorption2.61223506
17* MP0009643_abnormal_urine_homeostasis2.40632306
18MP0009840_abnormal_foam_cell2.29318618
19MP0003866_abnormal_defecation2.18624145
20MP0005083_abnormal_biliary_tract2.08857065
21MP0003191_abnormal_cellular_cholesterol2.08249643
22MP0005636_abnormal_mineral_homeostasis1.93511648
23MP0005023_abnormal_wound_healing1.83454010
24MP0001664_abnormal_digestion1.83321652
25MP0001873_stomach_inflammation1.80326414
26MP0000609_abnormal_liver_physiology1.72252607
27MP0002118_abnormal_lipid_homeostasis1.72028004
28MP0005319_abnormal_enzyme/_coenzyme1.71461101
29MP0001765_abnormal_ion_homeostasis1.69476058
30MP0005584_abnormal_enzyme/coenzyme_acti1.61880031
31MP0010234_abnormal_vibrissa_follicle1.52516606
32* MP0002136_abnormal_kidney_physiology1.48677772
33* MP0001756_abnormal_urination1.46767494
34MP0003186_abnormal_redox_activity1.45836452
35MP0010352_gastrointestinal_tract_polyps1.43883815
36MP0001764_abnormal_homeostasis1.38978770
37MP0005451_abnormal_body_composition1.36705524
38MP0003300_gastrointestinal_ulcer1.35106476
39MP0005084_abnormal_gallbladder_morpholo1.34823618
40MP0004272_abnormal_basement_membrane1.34005059
41MP0003868_abnormal_feces_composition1.29551348
42MP0004264_abnormal_extraembryonic_tissu1.24440310
43MP0003183_abnormal_peptide_metabolism1.20476005
44MP0004782_abnormal_surfactant_physiolog1.18695194
45MP0002132_abnormal_respiratory_system1.16286313
46MP0003136_yellow_coat_color1.12634052
47MP0002928_abnormal_bile_duct1.06523113
48MP0000477_abnormal_intestine_morphology1.04324718
49MP0002876_abnormal_thyroid_physiology1.03480526
50MP0002089_abnormal_postnatal_growth/wei1.03103417
51MP0000490_abnormal_crypts_of1.02567515
52MP0001188_hyperpigmentation1.00629588
53MP0000598_abnormal_liver_morphology0.98034726
54MP0000538_abnormal_urinary_bladder0.97312189
55MP0009764_decreased_sensitivity_to0.96257446
56MP0005058_abnormal_lysosome_morphology0.95093964
57MP0003045_fibrosis0.94885420
58MP0003705_abnormal_hypodermis_morpholog0.93801027
59MP0005220_abnormal_exocrine_pancreas0.92272474
60MP0004858_abnormal_nervous_system0.91962505
61MP0006036_abnormal_mitochondrial_physio0.91943016
62MP0009785_altered_susceptibility_to0.90434186
63MP0005377_hearing/vestibular/ear_phenot0.89822129
64MP0003878_abnormal_ear_physiology0.89822129
65MP0003879_abnormal_hair_cell0.89401882
66MP0000465_gastrointestinal_hemorrhage0.88302291
67MP0009642_abnormal_blood_homeostasis0.87043370
68MP0003011_delayed_dark_adaptation0.86720767
69MP0004233_abnormal_muscle_weight0.84217851
70MP0003453_abnormal_keratinocyte_physiol0.83999825
71MP0001881_abnormal_mammary_gland0.82599809
72MP0005408_hypopigmentation0.81768448
73MP0000604_amyloidosis0.80177704
74MP0008469_abnormal_protein_level0.80162377
75MP0002277_abnormal_respiratory_mucosa0.78804591
76MP0003566_abnormal_cell_adhesion0.78319046
77MP0008004_abnormal_stomach_pH0.75878168
78MP0002168_other_aberrant_phenotype0.73136058
79MP0000249_abnormal_blood_vessel0.72994941
80MP0001485_abnormal_pinna_reflex0.71051294
81MP0005670_abnormal_white_adipose0.70026128
82MP0002796_impaired_skin_barrier0.69814176
83MP0010678_abnormal_skin_adnexa0.69179347
84MP0005535_abnormal_body_temperature0.68044718
85MP0003656_abnormal_erythrocyte_physiolo0.67987256
86MP0001661_extended_life_span0.67733603
87MP0001958_emphysema0.66424330
88MP0009763_increased_sensitivity_to0.66410533
89MP0003329_amyloid_beta_deposits0.65850937
90MP0002078_abnormal_glucose_homeostasis0.64810237
91MP0000230_abnormal_systemic_arterial0.64778824
92MP0008961_abnormal_basal_metabolism0.64140012
93MP0005395_other_phenotype0.63979113
94MP0003638_abnormal_response/metabolism_0.63742649
95MP0005666_abnormal_adipose_tissue0.63313175
96MP0004147_increased_porphyrin_level0.62919071
97MP0003943_abnormal_hepatobiliary_system0.62660563
98MP0005647_abnormal_sex_gland0.62356194
99MP0005448_abnormal_energy_balance0.61150341
100MP0009765_abnormal_xenobiotic_induced0.60581244
101MP0002135_abnormal_kidney_morphology0.59949398
102MP0002166_altered_tumor_susceptibility0.59597251
103MP0005376_homeostasis/metabolism_phenot0.58934373
104MP0009697_abnormal_copulation0.57996762
105MP0002254_reproductive_system_inflammat0.57626184
106MP0003436_decreased_susceptibility_to0.55464846
107MP0002971_abnormal_brown_adipose0.52245505
108MP0006138_congestive_heart_failure0.51052812
109MP0009053_abnormal_anal_canal0.50282984
110MP0005025_abnormal_response_to0.49749093
111MP0005166_decreased_susceptibility_to0.49254921
112MP0004947_skin_inflammation0.48679502
113MP0005164_abnormal_response_to0.48520798
114MP0005167_abnormal_blood-brain_barrier0.48308450
115MP0000534_abnormal_ureter_morphology0.48150493
116MP0002163_abnormal_gland_morphology0.48008035
117MP0001663_abnormal_digestive_system0.47837050
118MP0006035_abnormal_mitochondrial_morpho0.47591322
119MP0000343_altered_response_to0.47364453
120MP0000627_abnormal_mammary_gland0.45790747
121MP0008872_abnormal_physiological_respon0.44736164
122MP0001944_abnormal_pancreas_morphology0.44507056
123MP0003953_abnormal_hormone_level0.42949332
124MP0005334_abnormal_fat_pad0.42861822
125MP0009384_cardiac_valve_regurgitation0.42239808
126MP0002896_abnormal_bone_mineralization0.41629297
127MP0005266_abnormal_metabolism0.41594069
128MP0005501_abnormal_skin_physiology0.38717566
129MP0005381_digestive/alimentary_phenotyp0.38604156
130MP0003724_increased_susceptibility_to0.37717774
131MP0000462_abnormal_digestive_system0.35158774
132MP0002098_abnormal_vibrissa_morphology0.34675731
133MP0010368_abnormal_lymphatic_system0.34519486
134MP0008873_increased_physiological_sensi0.34399903
135MP0005165_increased_susceptibility_to0.34195029
136MP0003959_abnormal_lean_body0.34010861
137MP0001845_abnormal_inflammatory_respons0.33554999
138MP0003075_altered_response_to0.32487663
139MP0010155_abnormal_intestine_physiology0.31864934
140MP0003690_abnormal_glial_cell0.31771011
141MP0004130_abnormal_muscle_cell0.31715104
142MP0003718_maternal_effect0.30542030
143MP0004885_abnormal_endolymph0.30113295

Predicted human phenotypes

RankGene SetZ-score
1Exocrine pancreatic insufficiency (HP:0001738)5.66795834
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.52069397
3Abnormality of glutamine family amino acid metabolism (HP:0010902)5.45939103
4Gout (HP:0001997)5.42195852
5Intrahepatic cholestasis (HP:0001406)5.21978154
6Hyperglycinuria (HP:0003108)4.95477869
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.79477653
8Xanthomatosis (HP:0000991)4.57913334
9Deep venous thrombosis (HP:0002625)4.52834733
10Abnormality of serine family amino acid metabolism (HP:0010894)4.45861460
11Abnormality of glycine metabolism (HP:0010895)4.45861460
12Cerebral palsy (HP:0100021)4.35217453
13Abnormality of purine metabolism (HP:0004352)4.27581421
14Ketosis (HP:0001946)4.23155131
15Hyperammonemia (HP:0001987)4.18464312
16Growth hormone excess (HP:0000845)4.13551781
17Proximal tubulopathy (HP:0000114)4.12974325
18Systemic lupus erythematosus (HP:0002725)4.12312341
19Facial shape deformation (HP:0011334)4.11629581
20Potter facies (HP:0002009)4.11629581
21Hyperglycinemia (HP:0002154)4.06960796
22Increased circulating renin level (HP:0000848)4.06836878
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06110686
24Increased purine levels (HP:0004368)4.04457057
25Hyperuricemia (HP:0002149)4.04457057
26Hypobetalipoproteinemia (HP:0003563)4.02587036
27Hypokalemic alkalosis (HP:0001949)4.00883329
28Hyperactive renin-angiotensin system (HP:0000841)3.99979956
29Metabolic alkalosis (HP:0200114)3.96808544
30Ketoacidosis (HP:0001993)3.86302460
31Glomerulonephritis (HP:0000099)3.81323564
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.78782482
33Alkalosis (HP:0001948)3.75758384
34Abnormality of nucleobase metabolism (HP:0010932)3.74634299
35Abnormality of chloride homeostasis (HP:0011422)3.65755898
36Abnormality of fatty-acid metabolism (HP:0004359)3.61917547
37Neonatal death (HP:0003811)3.55373139
38Prolonged partial thromboplastin time (HP:0003645)3.54693827
39Abnormal urine output (HP:0012590)3.49452422
40Right ventricular cardiomyopathy (HP:0011663)3.45794794
41Polyuria (HP:0000103)3.44386492
42Hypomagnesemia (HP:0002917)3.43393349
43Abnormality of renal excretion (HP:0011036)3.38088270
44Generalized aminoaciduria (HP:0002909)3.33277399
45Hypoglycemic coma (HP:0001325)3.26777285
46Focal segmental glomerulosclerosis (HP:0000097)3.26325195
47Complement deficiency (HP:0004431)3.23759808
48Vascular calcification (HP:0004934)3.23738325
49Abnormality of urine glucose concentration (HP:0011016)3.23440621
50Glycosuria (HP:0003076)3.23440621
51Delayed CNS myelination (HP:0002188)3.18590854
52Fat malabsorption (HP:0002630)3.18076895
53Seborrheic dermatitis (HP:0001051)3.16375439
54Severe visual impairment (HP:0001141)3.15371665
55Arterial tortuosity (HP:0005116)3.14553311
56Glomerulosclerosis (HP:0000096)3.14014692
57Hyperlipoproteinemia (HP:0010980)3.13960276
58Goiter (HP:0000853)3.13667389
59Rectal prolapse (HP:0002035)3.10632109
60Nephritis (HP:0000123)3.08064097
61Malnutrition (HP:0004395)3.07529335
62Abnormality of proline metabolism (HP:0010907)3.03564441
63Hydroxyprolinuria (HP:0003080)3.03564441
64Hypolipoproteinemia (HP:0010981)3.00092465
65Abnormality of macular pigmentation (HP:0008002)2.99136342
66Abnormality of the gastric mucosa (HP:0004295)2.98241121
67Abnormality of magnesium homeostasis (HP:0004921)2.94855951
68Metabolic acidosis (HP:0001942)2.94743927
69Joint hemorrhage (HP:0005261)2.92124474
70Conjugated hyperbilirubinemia (HP:0002908)2.90156064
71Congenital sensorineural hearing impairment (HP:0008527)2.89290163
72Hypoproteinemia (HP:0003075)2.88102024
73Cardiovascular calcification (HP:0011915)2.87190904
74Epidermoid cyst (HP:0200040)2.86382950
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.84091687
76Dicarboxylic aciduria (HP:0003215)2.84091687
77Lethargy (HP:0001254)2.77332082
78Tubulointerstitial fibrosis (HP:0005576)2.77201274
79Scotoma (HP:0000575)2.76886126
80Abnormality of the common coagulation pathway (HP:0010990)2.75643676
81Vascular tortuosity (HP:0004948)2.72045414
82Abnormality of pyrimidine metabolism (HP:0004353)2.68740056
83Abnormality of serum amino acid levels (HP:0003112)2.68530156
84Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.67535773
85Abnormality of methionine metabolism (HP:0010901)2.64554127
86Rickets (HP:0002748)2.64344250
87Hepatocellular carcinoma (HP:0001402)2.63815257
88Joint swelling (HP:0001386)2.55786536
89Hypoalphalipoproteinemia (HP:0003233)2.55617796
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.54528650
91Nephrolithiasis (HP:0000787)2.53562249
92Hyperphosphaturia (HP:0003109)2.53368142
93Abnormal drinking behavior (HP:0030082)2.53038172
94Polydipsia (HP:0001959)2.53038172
95Hyperbilirubinemia (HP:0002904)2.52279836
96Abnormality of renin-angiotensin system (HP:0000847)2.51329487
97Vomiting (HP:0002013)2.49816092
98Tetany (HP:0001281)2.49346715
99Enlarged kidneys (HP:0000105)2.49129734
100Renal tubular acidosis (HP:0001947)2.48958775
101Hemorrhage of the eye (HP:0011885)2.47901554
102Renal salt wasting (HP:0000127)2.47002089
103Late onset (HP:0003584)2.42690763
104Hyperaldosteronism (HP:0000859)2.42600362
105Mitral stenosis (HP:0001718)2.40934178
106Spastic diplegia (HP:0001264)2.38528059
107Irritability (HP:0000737)2.36398591
108Abnormal enzyme/coenzyme activity (HP:0012379)2.32936844
109Sensorimotor neuropathy (HP:0007141)2.30007305
110Confusion (HP:0001289)2.29319297
111Abnormality of complement system (HP:0005339)2.27566830
112Abnormal urine phosphate concentration (HP:0012599)2.25532614
113Abnormality of the intrinsic pathway (HP:0010989)2.23680232
114Steatorrhea (HP:0002570)2.21839967
115Hypercholesterolemia (HP:0003124)2.21574609
116Neonatal onset (HP:0003623)2.19699406
117Hypophosphatemia (HP:0002148)2.16717628
118Hypercalciuria (HP:0002150)2.15862813
119Abnormality of alkaline phosphatase activity (HP:0004379)2.14754087
120Bone pain (HP:0002653)2.13453769
121Hypothermia (HP:0002045)2.10992343
122Chronic diarrhea (HP:0002028)2.10689650
123Esophageal varix (HP:0002040)2.08476534
124Abnormality of carpal bone ossification (HP:0006257)2.08202567
125Ileus (HP:0002595)2.04536385
126Abnormal pancreas size (HP:0012094)2.04428791
127Cerebral edema (HP:0002181)2.04014439
128Aortic aneurysm (HP:0004942)2.01813586
129Nausea (HP:0002018)1.98859128
130Dehydration (HP:0001944)1.98520553
131Abdominal distention (HP:0003270)1.97962384
132Pancreatitis (HP:0001733)1.97780774
133Abnormality of the nasal septum (HP:0000419)1.96596303
134Hypophosphatemic rickets (HP:0004912)1.96536998
135Abnormality of vitamin metabolism (HP:0100508)1.93565611
136Hypotension (HP:0002615)1.92464662
137Flat acetabular roof (HP:0003180)1.92311770
138Abnormal biliary tract morphology (HP:0012440)1.91827623
139Abnormal cortical bone morphology (HP:0003103)1.84768120
140Abnormal glucose tolerance (HP:0001952)1.84683149
141Bronchomalacia (HP:0002780)1.82650197
142Male infertility (HP:0003251)1.79238721
143Abnormality of the vitamin B12 metabolism (HP:0004341)1.78683205
144Abnormality of polysaccharide metabolism (HP:0011012)1.73836995
145Abnormality of glycosaminoglycan metabolism (HP:0004371)1.73836995
146Abnormality of mucopolysaccharide metabolism (HP:0011020)1.73836995
147Mucopolysacchariduria (HP:0008155)1.72134806
148Urinary glycosaminoglycan excretion (HP:0003541)1.72134806
149Abnormality of the right ventricle (HP:0001707)1.70493967
150Abnormality of the distal phalanges of the toes (HP:0010182)1.69875087

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.82028031
2WNK35.27134615
3OXSR15.01185663
4BCKDK4.85421020
5MST1R3.17656686
6STK392.98820615
7FGFR42.83669281
8ERN12.77122588
9MAP3K122.69818384
10FRK2.68358479
11STK38L2.24673338
12STK242.06576777
13SIK11.92583759
14NME11.85863374
15ERBB41.78171769
16LMTK21.72377701
17PTK61.69826344
18EPHA21.64796067
19PDK31.46894467
20PDK41.46894467
21LATS11.45120942
22INSRR1.44118675
23PKN21.38764883
24TAOK31.33261466
25MST41.32279994
26TRIB31.31982642
27ACVR1B1.28079132
28MAPK111.27083055
29NEK11.24824615
30GRK61.19537153
31MET1.16105055
32MAP3K31.14231979
33RIPK11.10609493
34SGK4941.09816533
35SGK2231.09816533
36ILK1.08356783
37TNIK1.08200739
38NEK91.06658049
39MAP3K71.05908652
40PTK21.05450360
41EPHB11.03745691
42MAP2K20.98584881
43EPHA30.98526594
44MAP3K20.95748772
45PDK20.94239549
46GSK3A0.91099419
47PRKAA20.90530908
48ZAP700.90053820
49ABL20.89881673
50LRRK20.87400767
51STK380.82970840
52NLK0.82849898
53FER0.82148950
54MAP3K60.81737993
55DYRK1B0.81256229
56ERBB20.80963137
57SGK30.80203668
58PRKG20.78522331
59MAP2K40.77998173
60TGFBR20.77541847
61PIK3CG0.73266876
62DDR20.70264384
63PRKAA10.69554981
64WNK10.68503289
65ICK0.65084118
66PAK40.64351038
67MAPK150.64311859
68TYK20.64083936
69JAK20.63149805
70PDGFRB0.62101512
71FLT30.62061741
72CDC42BPA0.61194661
73MAP3K110.60740908
74MAP3K140.59920705
75MAP2K60.59725401
76PRKCZ0.58409312
77SGK20.57704667
78ROCK10.57549357
79MAP2K10.57291464
80TESK10.57251837
81PBK0.57224228
82PRKCE0.57145749
83PINK10.54356360
84IKBKE0.54092907
85FGFR20.53892319
86DAPK10.53689971
87CDK60.53488915
88PAK30.51874356
89MYLK0.51674996
90EPHB20.51105661
91KDR0.50955807
92MAP3K100.50901107
93PDPK10.49560239
94FGFR30.48391980
95TBK10.46468659
96CHUK0.46120550
97TIE10.45876985
98PRKACG0.45017523
99CAMK2G0.44248066
100PDGFRA0.43658723
101SRC0.43522446
102MAP2K30.42657070
103DAPK20.42557652
104IRAK30.39936103
105AKT30.38977585
106CDK90.36733501
107CSK0.36358705
108HIPK20.35929056
109STK100.35454028
110RPS6KA40.34309760
111MAP3K10.32122660
112MAPK40.31841537
113MELK0.31670807
114PRKD20.30436239
115MAP3K130.30111300
116JAK10.29255962
117DAPK30.28863046
118PRKD10.27376694
119RPS6KA20.27348056
120PDK10.26882763
121BMPR1B0.26834638
122DMPK0.26756894
123IKBKB0.26461054
124PRKCI0.26120180
125CSNK1G10.25201527
126PRKCQ0.24987254
127BMX0.24921459
128NUAK10.24620577
129SGK10.24443860
130PRKCA0.24253427
131GRK10.23298879
132PIK3CA0.22936027
133PRPF4B0.22619646
134AKT20.22590013
135MATK0.21633530
136ERBB30.21472557
137STK30.21402237
138VRK20.20882132
139IGF1R0.20650299
140CAMK2D0.20435125
141KSR20.19974331
142PRKCD0.18509010

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.58999336
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.37737262
3Nitrogen metabolism_Homo sapiens_hsa009103.11380770
4Pancreatic secretion_Homo sapiens_hsa049722.97310829
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.91910115
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.85269600
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72948828
8Tryptophan metabolism_Homo sapiens_hsa003802.70354216
9Butanoate metabolism_Homo sapiens_hsa006502.69876896
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.65243152
11Fatty acid degradation_Homo sapiens_hsa000712.64041321
12Arginine biosynthesis_Homo sapiens_hsa002202.55890261
13Propanoate metabolism_Homo sapiens_hsa006402.39500694
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.35513204
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35249870
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.27767517
17Peroxisome_Homo sapiens_hsa041462.26807344
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07860085
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.98397999
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.91833913
21Fatty acid metabolism_Homo sapiens_hsa012121.87198250
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86683034
23beta-Alanine metabolism_Homo sapiens_hsa004101.84324048
24Pyruvate metabolism_Homo sapiens_hsa006201.83999843
25Bile secretion_Homo sapiens_hsa049761.80675504
26Complement and coagulation cascades_Homo sapiens_hsa046101.80539540
27Sulfur metabolism_Homo sapiens_hsa009201.80431146
28PPAR signaling pathway_Homo sapiens_hsa033201.79493438
29Histidine metabolism_Homo sapiens_hsa003401.75788974
30Vitamin digestion and absorption_Homo sapiens_hsa049771.62420110
31Chemical carcinogenesis_Homo sapiens_hsa052041.57475051
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57251607
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52057194
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46715738
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.46227919
36Carbon metabolism_Homo sapiens_hsa012001.44876354
37Selenocompound metabolism_Homo sapiens_hsa004501.44020537
38Starch and sucrose metabolism_Homo sapiens_hsa005001.36301234
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.36050523
40Retinol metabolism_Homo sapiens_hsa008301.34638882
41Folate biosynthesis_Homo sapiens_hsa007901.33170768
42Phenylalanine metabolism_Homo sapiens_hsa003601.32768250
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30493075
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27987797
45Glutathione metabolism_Homo sapiens_hsa004801.24136724
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.22941690
47Biosynthesis of amino acids_Homo sapiens_hsa012301.21679141
48Arginine and proline metabolism_Homo sapiens_hsa003301.20107599
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.12135584
50Fat digestion and absorption_Homo sapiens_hsa049751.10510949
51Caffeine metabolism_Homo sapiens_hsa002321.10152458
52Fatty acid elongation_Homo sapiens_hsa000621.09948279
53Steroid biosynthesis_Homo sapiens_hsa001001.03138676
54Tyrosine metabolism_Homo sapiens_hsa003501.02752661
55Lysine degradation_Homo sapiens_hsa003101.01790541
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98905328
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98417196
58Staphylococcus aureus infection_Homo sapiens_hsa051500.96496134
59ABC transporters_Homo sapiens_hsa020100.93153457
60Glycerolipid metabolism_Homo sapiens_hsa005610.87589219
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86948283
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85590129
63Pentose phosphate pathway_Homo sapiens_hsa000300.76114717
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72516180
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71657136
66Sulfur relay system_Homo sapiens_hsa041220.69271252
67Sphingolipid metabolism_Homo sapiens_hsa006000.64455281
68Mineral absorption_Homo sapiens_hsa049780.63124811
69Fructose and mannose metabolism_Homo sapiens_hsa000510.63115967
70Vibrio cholerae infection_Homo sapiens_hsa051100.55350670
71Ether lipid metabolism_Homo sapiens_hsa005650.54712457
72* Tight junction_Homo sapiens_hsa045300.53676755
73Metabolic pathways_Homo sapiens_hsa011000.51497349
74Protein digestion and absorption_Homo sapiens_hsa049740.41744418
75Pertussis_Homo sapiens_hsa051330.41618870
76One carbon pool by folate_Homo sapiens_hsa006700.39163748
77Vitamin B6 metabolism_Homo sapiens_hsa007500.38886583
78TNF signaling pathway_Homo sapiens_hsa046680.38711669
79Renin-angiotensin system_Homo sapiens_hsa046140.36123094
80* Leukocyte transendothelial migration_Homo sapiens_hsa046700.35808374
81African trypanosomiasis_Homo sapiens_hsa051430.34094574
82Galactose metabolism_Homo sapiens_hsa000520.33622420
83Influenza A_Homo sapiens_hsa051640.33151608
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31405868
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.29995237
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29686576
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25812497
88Other glycan degradation_Homo sapiens_hsa005110.23135905
89Fatty acid biosynthesis_Homo sapiens_hsa000610.22028823
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21282877
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21152168
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20115562
93Amoebiasis_Homo sapiens_hsa051460.19539905
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19240988
95N-Glycan biosynthesis_Homo sapiens_hsa005100.18588435
96Thyroid hormone synthesis_Homo sapiens_hsa049180.18480450
97Asthma_Homo sapiens_hsa053100.17923779
98ECM-receptor interaction_Homo sapiens_hsa045120.17764202
99Collecting duct acid secretion_Homo sapiens_hsa049660.17269807
100Insulin resistance_Homo sapiens_hsa049310.16853087
101Adherens junction_Homo sapiens_hsa045200.16697302
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.15237711
103Choline metabolism in cancer_Homo sapiens_hsa052310.14259361
104* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.13740740
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13489656
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.12815537
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.07949832
108Arachidonic acid metabolism_Homo sapiens_hsa005900.07448133
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04104031
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.04086471
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.03057156
112AMPK signaling pathway_Homo sapiens_hsa041520.02010430
113Parkinsons disease_Homo sapiens_hsa05012-0.2020999
114Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1966465
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1714755
116* Hepatitis C_Homo sapiens_hsa05160-0.1321039
117Oxidative phosphorylation_Homo sapiens_hsa00190-0.0759846
118Bladder cancer_Homo sapiens_hsa05219-0.0269819
119Linoleic acid metabolism_Homo sapiens_hsa00591-0.0231849
120Prion diseases_Homo sapiens_hsa05020-0.0221972
121Lysosome_Homo sapiens_hsa04142-0.0065735
122Glucagon signaling pathway_Homo sapiens_hsa04922-0.0024068
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0011243

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