CLDN19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of pigment cell differentiation (GO:0050932)6.88613668
2axon ensheathment in central nervous system (GO:0032291)5.96331281
3central nervous system myelination (GO:0022010)5.96331281
4presynaptic membrane assembly (GO:0097105)5.17103222
5axon ensheathment (GO:0008366)4.90583258
6ensheathment of neurons (GO:0007272)4.90583258
7presynaptic membrane organization (GO:0097090)4.63847894
8myelination in peripheral nervous system (GO:0022011)4.44175531
9peripheral nervous system axon ensheathment (GO:0032292)4.44175531
10cranial nerve structural organization (GO:0021604)4.39107861
11myelination (GO:0042552)4.37887186
12positive regulation of developmental pigmentation (GO:0048087)4.28093039
13regulation of gene silencing by RNA (GO:0060966)4.22951796
14regulation of posttranscriptional gene silencing (GO:0060147)4.22951796
15regulation of gene silencing by miRNA (GO:0060964)4.22951796
16cell-cell junction maintenance (GO:0045217)4.16289444
17postsynaptic membrane organization (GO:0001941)4.15213625
18regulation of cholesterol esterification (GO:0010872)3.75031891
19facial nerve structural organization (GO:0021612)3.69848144
20plasma lipoprotein particle assembly (GO:0034377)3.66405268
21high-density lipoprotein particle remodeling (GO:0034375)3.63745327
22ribosomal small subunit biogenesis (GO:0042274)3.58593213
23fatty acid elongation (GO:0030497)3.56406882
24positive regulation of cellular amine metabolic process (GO:0033240)3.53583223
25cranial nerve morphogenesis (GO:0021602)3.53283098
26mannosylation (GO:0097502)3.48458540
27GPI anchor biosynthetic process (GO:0006506)3.46815335
28lymphoid progenitor cell differentiation (GO:0002320)3.45628951
29lysine catabolic process (GO:0006554)3.40076351
30lysine metabolic process (GO:0006553)3.40076351
31peripheral nervous system development (GO:0007422)3.38034909
32reverse cholesterol transport (GO:0043691)3.37309112
33negative regulation of execution phase of apoptosis (GO:1900118)3.35167069
34aspartate family amino acid catabolic process (GO:0009068)3.32720152
35regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.28145308
36viral transcription (GO:0019083)3.28009138
37limb bud formation (GO:0060174)3.24052688
38female gonad development (GO:0008585)3.23862508
39phospholipid efflux (GO:0033700)3.21085904
40negative regulation of cholesterol transport (GO:0032375)3.20390442
41negative regulation of sterol transport (GO:0032372)3.20390442
42long-chain fatty acid biosynthetic process (GO:0042759)3.19515251
43regulation of developmental pigmentation (GO:0048070)3.16161548
44platelet dense granule organization (GO:0060155)3.12670469
45protein heterotetramerization (GO:0051290)3.12522727
46GPI anchor metabolic process (GO:0006505)3.11750114
47developmental pigmentation (GO:0048066)3.11703514
48metanephric tubule development (GO:0072170)3.11372594
49metanephric nephron tubule development (GO:0072234)3.11372594
50mesonephros development (GO:0001823)3.05974372
51regulation of hexokinase activity (GO:1903299)3.04288604
52regulation of glucokinase activity (GO:0033131)3.04288604
53magnesium ion transport (GO:0015693)3.04088627
54short-term memory (GO:0007614)3.03254188
55serine family amino acid catabolic process (GO:0009071)3.00921376
56translational termination (GO:0006415)3.00654380
57regulation of non-canonical Wnt signaling pathway (GO:2000050)2.99699807
58cotranslational protein targeting to membrane (GO:0006613)2.97880589
59nephron tubule morphogenesis (GO:0072078)2.96785215
60nephron epithelium morphogenesis (GO:0072088)2.96785215
61oligodendrocyte differentiation (GO:0048709)2.96157282
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.96050710
63negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.94974865
64branched-chain amino acid catabolic process (GO:0009083)2.94698647
65respiratory chain complex IV assembly (GO:0008535)2.93703576
66sympathetic nervous system development (GO:0048485)2.92947790
67protein targeting to ER (GO:0045047)2.92662538
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91910288
69positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.90922276
70endothelium development (GO:0003158)2.88950578
71cranial nerve development (GO:0021545)2.87496249
72detection of light stimulus involved in visual perception (GO:0050908)2.87361546
73detection of light stimulus involved in sensory perception (GO:0050962)2.87361546
74transepithelial transport (GO:0070633)2.87155703
75nephron tubule formation (GO:0072079)2.86446798
76negative regulation of leukocyte chemotaxis (GO:0002689)2.86115363
77aldehyde catabolic process (GO:0046185)2.83847648
78response to folic acid (GO:0051593)2.83594274
79lung-associated mesenchyme development (GO:0060484)2.83353568
80protein-lipid complex assembly (GO:0065005)2.83090616
81C-terminal protein lipidation (GO:0006501)2.81933925
82negative regulation of translation, ncRNA-mediated (GO:0040033)2.81631318
83regulation of translation, ncRNA-mediated (GO:0045974)2.81631318
84negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81631318
85anatomical structure arrangement (GO:0048532)2.81567553
86positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.81536450
87nonmotile primary cilium assembly (GO:0035058)2.80990715
88water-soluble vitamin biosynthetic process (GO:0042364)2.80655028
89regulation of timing of cell differentiation (GO:0048505)2.80555497
90protein-cofactor linkage (GO:0018065)2.80089391
91negative regulation of transcription by competitive promoter binding (GO:0010944)2.79822798
92establishment of protein localization to endoplasmic reticulum (GO:0072599)2.79480445
93protein localization to endoplasmic reticulum (GO:0070972)2.78975292
94regulation of cilium movement (GO:0003352)2.78931397
95glycine metabolic process (GO:0006544)2.78246242
96metanephric nephron epithelium development (GO:0072243)2.77843041
97DNA damage response, detection of DNA damage (GO:0042769)2.77283986
98neuron cell-cell adhesion (GO:0007158)2.76953000
99nephron epithelium development (GO:0072009)2.76381888
100very-low-density lipoprotein particle assembly (GO:0034379)2.76128423
101pattern specification involved in kidney development (GO:0061004)2.75794108
102homocysteine metabolic process (GO:0050667)2.74527641
103mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.74424869
104DNA strand renaturation (GO:0000733)2.73143183
105enteric nervous system development (GO:0048484)2.73115441
106L-serine metabolic process (GO:0006563)2.71987082
107amino sugar catabolic process (GO:0046348)2.71121979
108chaperone-mediated protein transport (GO:0072321)2.70492859
109metanephric epithelium development (GO:0072207)2.70168300
110kidney morphogenesis (GO:0060993)2.69997140
111negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.69877012
112behavioral response to nicotine (GO:0035095)2.69453629
113triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.69220611
114C4-dicarboxylate transport (GO:0015740)2.68726446
115photoreceptor cell differentiation (GO:0046530)2.67861793
116eye photoreceptor cell differentiation (GO:0001754)2.67861793
117somite development (GO:0061053)2.67176830
118cerebral cortex radially oriented cell migration (GO:0021799)2.66808797
119cholesterol biosynthetic process (GO:0006695)2.64928267
120peptidyl-tyrosine autophosphorylation (GO:0038083)2.64486562
121indolalkylamine metabolic process (GO:0006586)2.61481371
122cytochrome complex assembly (GO:0017004)2.60949831
123cell junction maintenance (GO:0034331)2.60661241
124sphingoid metabolic process (GO:0046519)2.59787388
125mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.58767099
126replication fork processing (GO:0031297)2.58106299
127glyoxylate metabolic process (GO:0046487)2.57830743
128male sex determination (GO:0030238)2.56942199
129Leydig cell differentiation (GO:0033327)2.56507119
130fucose catabolic process (GO:0019317)2.55929349
131L-fucose metabolic process (GO:0042354)2.55929349
132L-fucose catabolic process (GO:0042355)2.55929349
133omega-hydroxylase P450 pathway (GO:0097267)2.55773169
134protein-lipid complex remodeling (GO:0034368)2.55586115
135macromolecular complex remodeling (GO:0034367)2.55586115
136plasma lipoprotein particle remodeling (GO:0034369)2.55586115
137response to pheromone (GO:0019236)2.55141746
138photoreceptor cell maintenance (GO:0045494)2.54899803
139negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.54429489
140polyol transport (GO:0015791)2.54086673
141excretion (GO:0007588)2.53901556
142DNA ligation (GO:0006266)2.52647970
143sterol biosynthetic process (GO:0016126)2.51885331
144negative regulation of protein localization to cell surface (GO:2000009)2.51849971
145keratinocyte development (GO:0003334)2.51035815
146serine family amino acid metabolic process (GO:0009069)2.48458864
147regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.47568763
148regulation of hippo signaling (GO:0035330)2.46537418
149regulation of nuclear cell cycle DNA replication (GO:0033262)2.45209670
150cell differentiation involved in metanephros development (GO:0072202)2.43857960
151cholesterol efflux (GO:0033344)2.42550785
152regulation of development, heterochronic (GO:0040034)2.42361069
153C-terminal protein amino acid modification (GO:0018410)2.41808609
154membrane assembly (GO:0071709)2.41699303
155negative regulation of lipase activity (GO:0060192)2.41456107
156L-ascorbic acid metabolic process (GO:0019852)2.41455042
157positive regulation of synapse assembly (GO:0051965)2.40865260
158urate metabolic process (GO:0046415)2.40155578
159L-alpha-amino acid transmembrane transport (GO:1902475)2.39946758
160cell fate commitment involved in formation of primary germ layer (GO:0060795)2.39031246
161DNA double-strand break processing (GO:0000729)2.39011399
162mesenchymal cell differentiation involved in kidney development (GO:0072161)2.38897337
163mesenchymal cell differentiation involved in renal system development (GO:2001012)2.38897337
164pseudouridine synthesis (GO:0001522)2.38463876
165protein neddylation (GO:0045116)2.38045270
166serine family amino acid biosynthetic process (GO:0009070)2.38024806
167intestinal cholesterol absorption (GO:0030299)2.37332671
168L-amino acid import (GO:0043092)2.37176014
169preassembly of GPI anchor in ER membrane (GO:0016254)2.35165703
170organ growth (GO:0035265)2.34185183
171positive regulation of smooth muscle cell migration (GO:0014911)2.33927152
172lateral sprouting from an epithelium (GO:0060601)2.31759987
173somite rostral/caudal axis specification (GO:0032525)2.30908690
174G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.30789781
175vitamin transmembrane transport (GO:0035461)2.29575631
176mast cell activation (GO:0045576)2.29096384
177kynurenine metabolic process (GO:0070189)2.28407976
178androgen biosynthetic process (GO:0006702)2.28043663
179regulation of mesenchymal cell apoptotic process (GO:2001053)2.27678019
180glycolipid biosynthetic process (GO:0009247)2.27512525
181pyrimidine nucleobase catabolic process (GO:0006208)2.27198792
182negative regulation of neurotransmitter transport (GO:0051589)2.26689512
183regulation of helicase activity (GO:0051095)2.26543642
184regulation of cytokine secretion involved in immune response (GO:0002739)2.26490536
185otic vesicle formation (GO:0030916)2.26063037
186plasma lipoprotein particle organization (GO:0071827)2.24180057
187lactate metabolic process (GO:0006089)2.23884756
188negative regulation of DNA-dependent DNA replication (GO:2000104)2.23576183
189S-adenosylmethionine metabolic process (GO:0046500)2.23271642
190cellular modified amino acid catabolic process (GO:0042219)2.23142583
191mitochondrial RNA metabolic process (GO:0000959)2.22123326
192cullin deneddylation (GO:0010388)2.21259918
193transcription elongation from RNA polymerase III promoter (GO:0006385)2.20634685
194termination of RNA polymerase III transcription (GO:0006386)2.20634685
195proteasome assembly (GO:0043248)2.20118326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.05864337
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.20701601
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.76563562
4ZNF274_21170338_ChIP-Seq_K562_Hela3.62340206
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.48300654
6GBX2_23144817_ChIP-Seq_PC3_Human3.37398749
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.17452337
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11396617
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93649563
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.76776449
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58723160
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54243845
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.53252912
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41810493
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.35764900
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.35016238
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34740285
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33700203
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30709532
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28910224
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.28190014
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.28083239
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.27709574
24CDX2_19796622_ChIP-Seq_MESCs_Mouse2.25606046
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25436882
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25436882
27TAF15_26573619_Chip-Seq_HEK293_Human2.22163505
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17508431
29JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17221238
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14797380
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10643423
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.09454172
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.06888667
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.97443730
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.93334684
36VDR_22108803_ChIP-Seq_LS180_Human1.92325679
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90844299
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86305052
39EWS_26573619_Chip-Seq_HEK293_Human1.83573480
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82776436
41IGF1R_20145208_ChIP-Seq_DFB_Human1.82645859
42AR_21572438_ChIP-Seq_LNCaP_Human1.80856812
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76351076
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75899795
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.73520809
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.70562539
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69961694
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69566696
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66151824
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.65195460
51P300_19829295_ChIP-Seq_ESCs_Human1.60001017
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59191644
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56597849
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.49380559
55MYC_18940864_ChIP-ChIP_HL60_Human1.48776702
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.48276394
57RNF2_27304074_Chip-Seq_NSC_Mouse1.47383946
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47195457
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46856044
60ELK1_19687146_ChIP-ChIP_HELA_Human1.46438164
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45682563
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45420641
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.45091371
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.44136687
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.43601093
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42770467
67ER_23166858_ChIP-Seq_MCF-7_Human1.42613589
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42515242
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41945974
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39616842
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39611753
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38505145
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38068572
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.37819943
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35978545
76P53_22387025_ChIP-Seq_ESCs_Mouse1.34909104
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34721032
78P300_18555785_Chip-Seq_ESCs_Mouse1.33420053
79TP63_17297297_ChIP-ChIP_HaCaT_Human1.33232219
80FUS_26573619_Chip-Seq_HEK293_Human1.33058525
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32344697
82* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32323392
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.31516080
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.30847683
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30576627
86NANOG_16153702_ChIP-ChIP_HESCs_Human1.30412291
87RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29613353
88TCF4_22108803_ChIP-Seq_LS180_Human1.29561919
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28741850
90E2F1_18555785_Chip-Seq_ESCs_Mouse1.28497956
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28440583
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.27697600
93NMYC_18555785_Chip-Seq_ESCs_Mouse1.27428576
94TP53_22573176_ChIP-Seq_HFKS_Human1.27349222
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.25669985
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.25323659
97NANOG_19829295_ChIP-Seq_ESCs_Human1.24992780
98SOX2_19829295_ChIP-Seq_ESCs_Human1.24992780
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.24787165
100TP53_18474530_ChIP-ChIP_U2OS_Human1.22724949
101FOXP3_21729870_ChIP-Seq_TREG_Human1.22696453
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22316910
103VDR_23849224_ChIP-Seq_CD4+_Human1.21511106
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19328358
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18751402
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18634961
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17967604
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17967604
109EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16181824
110BCAT_22108803_ChIP-Seq_LS180_Human1.15702338
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14513747
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.13561191
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.13527060
114OCT4_18555785_Chip-Seq_ESCs_Mouse1.12935521
115KDM2B_26808549_Chip-Seq_REH_Human1.12758651
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.12688724
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12384497
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12264783
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11583157
120SMAD4_21799915_ChIP-Seq_A2780_Human1.11431417
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11332117
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11020099
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.11003640
124SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10303609
125WT1_19549856_ChIP-ChIP_CCG9911_Human1.09322765
126SMAD3_21741376_ChIP-Seq_HESCs_Human1.08734818
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07888978
128CBP_20019798_ChIP-Seq_JUKART_Human1.05693534
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05693534
130KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04584346
131ZFX_18555785_Chip-Seq_ESCs_Mouse1.04214840
132SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03885529
133ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03429874
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03356668
135HOXB7_26014856_ChIP-Seq_BT474_Human1.02835622
136CTCF_18555785_Chip-Seq_ESCs_Mouse1.02619932
137IRF1_19129219_ChIP-ChIP_H3396_Human1.02482372
138PU1_27457419_Chip-Seq_LIVER_Mouse1.01853124
139* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01322506
140TRIM28_21343339_ChIP-Seq_HEK293_Human1.00220033
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00126356
142POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98343989
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96484366
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95981400
145YY1_21170310_ChIP-Seq_MESCs_Mouse0.95873344
146NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95515599
147* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95236815
148PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95208487
149FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95143378
150FOXA1_25329375_ChIP-Seq_VCAP_Human0.95143378
151FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94962702
152OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94825709
153RING1B_27294783_Chip-Seq_NPCs_Mouse0.93827796
154TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93785892
155IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93690443
156FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91806635
157TCF4_23295773_ChIP-Seq_U87_Human0.91608354
158* ETV1_20927104_ChIP-Seq_GIST48_Human0.91285296
159RUNX2_22187159_ChIP-Seq_PCA_Human0.90279619
160SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90019338
161RING1B_27294783_Chip-Seq_ESCs_Mouse0.89863747
162SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89815570
163PRDM14_20953172_ChIP-Seq_ESCs_Human0.89294611
164BP1_19119308_ChIP-ChIP_Hs578T_Human0.89033390
165* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.88814180
166AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88433090
167STAT3_23295773_ChIP-Seq_U87_Human0.88291965
168GATA3_21878914_ChIP-Seq_MCF-7_Human0.88013404
169PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87936556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color7.44664274
2MP0004381_abnormal_hair_follicle4.72249545
3MP0009379_abnormal_foot_pigmentation4.15789982
4MP0005409_darkened_coat_color3.96154181
5MP0002254_reproductive_system_inflammat3.71501590
6MP0000920_abnormal_myelination3.55887910
7MP0003195_calcinosis3.48662702
8MP0008260_abnormal_autophagy3.33062239
9MP0001188_hyperpigmentation3.18262463
10MP0004272_abnormal_basement_membrane2.93572503
11MP0001968_abnormal_touch/_nociception2.69241920
12MP0003880_abnormal_central_pattern2.49632095
13MP0005171_absent_coat_pigmentation2.38737415
14MP0005075_abnormal_melanosome_morpholog2.37991433
15MP0003122_maternal_imprinting2.35505443
16MP0010030_abnormal_orbit_morphology2.33652218
17MP0005174_abnormal_tail_pigmentation2.22811392
18MP0002138_abnormal_hepatobiliary_system2.20603485
19MP0006292_abnormal_olfactory_placode2.18975667
20MP0004133_heterotaxia2.14943228
21MP0008877_abnormal_DNA_methylation2.08734806
22MP0003315_abnormal_perineum_morphology2.07301785
23MP0002938_white_spotting2.03170306
24MP0003567_abnormal_fetal_cardiomyocyte1.96457380
25MP0002272_abnormal_nervous_system1.96005941
26MP0004019_abnormal_vitamin_homeostasis1.92243565
27MP0005377_hearing/vestibular/ear_phenot1.85272859
28MP0003878_abnormal_ear_physiology1.85272859
29MP0001293_anophthalmia1.82338961
30MP0001986_abnormal_taste_sensitivity1.81216914
31MP0003941_abnormal_skin_development1.80556042
32MP0001661_extended_life_span1.79734012
33MP0001984_abnormal_olfaction1.72669416
34MP0003718_maternal_effect1.71415165
35MP0005499_abnormal_olfactory_system1.71053044
36MP0005394_taste/olfaction_phenotype1.71053044
37MP0003890_abnormal_embryonic-extraembry1.68220567
38MP0000015_abnormal_ear_pigmentation1.67951464
39MP0004742_abnormal_vestibular_system1.66963230
40MP0008789_abnormal_olfactory_epithelium1.66497197
41MP0003724_increased_susceptibility_to1.66432319
42MP0001529_abnormal_vocalization1.65541944
43MP0002095_abnormal_skin_pigmentation1.64712336
44MP0002067_abnormal_sensory_capabilities1.58602958
45MP0002734_abnormal_mechanical_nocicepti1.57510492
46MP0000372_irregular_coat_pigmentation1.57199316
47MP0004145_abnormal_muscle_electrophysio1.56362299
48* MP0003634_abnormal_glial_cell1.56235578
49MP0004142_abnormal_muscle_tone1.50698483
50MP0005423_abnormal_somatic_nervous1.48143019
51MP0005332_abnormal_amino_acid1.46667300
52MP0003937_abnormal_limbs/digits/tail_de1.45314410
53MP0000566_synostosis1.43162757
54MP0003119_abnormal_digestive_system1.42819262
55MP0002233_abnormal_nose_morphology1.39030191
56MP0010329_abnormal_lipoprotein_level1.34592502
57MP0002009_preneoplasia1.32005616
58MP0001756_abnormal_urination1.31667113
59MP0004270_analgesia1.29674126
60MP0003186_abnormal_redox_activity1.28514046
61MP0000647_abnormal_sebaceous_gland1.26997568
62MP0001286_abnormal_eye_development1.26287833
63MP0003121_genomic_imprinting1.25522215
64MP0003938_abnormal_ear_development1.25516324
65MP0006072_abnormal_retinal_apoptosis1.24877244
66MP0005636_abnormal_mineral_homeostasis1.24864953
67MP0000751_myopathy1.24522913
68MP0001486_abnormal_startle_reflex1.24377350
69MP0002102_abnormal_ear_morphology1.23596702
70MP0005084_abnormal_gallbladder_morpholo1.22364609
71MP0002751_abnormal_autonomic_nervous1.18913037
72MP0001324_abnormal_eye_pigmentation1.18389992
73MP0008872_abnormal_physiological_respon1.18185414
74MP0002234_abnormal_pharynx_morphology1.14045545
75MP0008569_lethality_at_weaning1.13791294
76MP0003693_abnormal_embryo_hatching1.13625167
77MP0001963_abnormal_hearing_physiology1.12701651
78MP0008875_abnormal_xenobiotic_pharmacok1.11379561
79MP0000026_abnormal_inner_ear1.11082596
80MP0009046_muscle_twitch1.11053834
81MP0001970_abnormal_pain_threshold1.10842930
82MP0003045_fibrosis1.09557075
83MP0001666_abnormal_nutrient_absorption1.08312754
84MP0008058_abnormal_DNA_repair1.07975005
85MP0006276_abnormal_autonomic_nervous1.07845197
86MP0005646_abnormal_pituitary_gland1.07508196
87MP0003011_delayed_dark_adaptation1.07426158
88MP0001905_abnormal_dopamine_level1.06457159
89MP0002736_abnormal_nociception_after1.05058019
90MP0000049_abnormal_middle_ear1.03372888
91MP0002733_abnormal_thermal_nociception1.03050958
92MP0005391_vision/eye_phenotype1.01539266
93MP0003787_abnormal_imprinting1.01446516
94MP0000778_abnormal_nervous_system1.00924912
95MP0005365_abnormal_bile_salt1.00904069
96MP0005360_urolithiasis1.00225980
97MP0004264_abnormal_extraembryonic_tissu0.99939513
98MP0001764_abnormal_homeostasis0.99441575
99MP0003950_abnormal_plasma_membrane0.99093798
100MP0005367_renal/urinary_system_phenotyp0.98290392
101MP0000516_abnormal_urinary_system0.98290392
102MP0000631_abnormal_neuroendocrine_gland0.98223666
103MP0005408_hypopigmentation0.98091327
104MP0002697_abnormal_eye_size0.97285003
105MP0004147_increased_porphyrin_level0.95016051
106MP0002752_abnormal_somatic_nervous0.94355708
107MP0002229_neurodegeneration0.92642463
108MP0001485_abnormal_pinna_reflex0.92163272
109MP0002638_abnormal_pupillary_reflex0.91463231
110MP0005551_abnormal_eye_electrophysiolog0.91202717
111MP0003755_abnormal_palate_morphology0.90592666
112MP0004885_abnormal_endolymph0.90084114
113MP0002557_abnormal_social/conspecific_i0.89977859
114MP0008995_early_reproductive_senescence0.89509375
115MP0009697_abnormal_copulation0.89070537
116MP0002177_abnormal_outer_ear0.88905417
117MP0002090_abnormal_vision0.88147861
118MP0005195_abnormal_posterior_eye0.87188337
119MP0000749_muscle_degeneration0.87059282
120MP0002249_abnormal_larynx_morphology0.84924525
121MP0002064_seizures0.84634597
122MP0008438_abnormal_cutaneous_collagen0.84428658
123MP0009643_abnormal_urine_homeostasis0.82930749
124MP0009672_abnormal_birth_weight0.82846458
125MP0000538_abnormal_urinary_bladder0.81875238
126MP0002876_abnormal_thyroid_physiology0.80404663
127MP0003123_paternal_imprinting0.79803290
128MP0003252_abnormal_bile_duct0.79086824
129MP0009703_decreased_birth_body0.78721762
130MP0005410_abnormal_fertilization0.78199079
131MP0005085_abnormal_gallbladder_physiolo0.78123311
132MP0001299_abnormal_eye_distance/0.77759664
133MP0005645_abnormal_hypothalamus_physiol0.75968452
134MP0005595_abnormal_vascular_smooth0.75418639
135MP0003632_abnormal_nervous_system0.75047411
136MP0000762_abnormal_tongue_morphology0.74266108
137MP0002148_abnormal_hypersensitivity_rea0.74244360
138MP0009745_abnormal_behavioral_response0.74089832
139MP0002277_abnormal_respiratory_mucosa0.73991579
140MP0004957_abnormal_blastocyst_morpholog0.73517066
141MP0002735_abnormal_chemical_nociception0.72848495
142MP0000653_abnormal_sex_gland0.72385331
143MP0009250_abnormal_appendicular_skeleto0.72219711
144MP0000465_gastrointestinal_hemorrhage0.72035312
145MP0002084_abnormal_developmental_patter0.71921650
146MP0002882_abnormal_neuron_morphology0.71711207
147MP0002282_abnormal_trachea_morphology0.71455617
148MP0002160_abnormal_reproductive_system0.71345748
149MP0005253_abnormal_eye_physiology0.70031070
150MP0001186_pigmentation_phenotype0.69631537
151MP0002184_abnormal_innervation0.69234297
152MP0003631_nervous_system_phenotype0.69136717
153MP0000681_abnormal_thyroid_gland0.68983072
154MP0005379_endocrine/exocrine_gland_phen0.68556289
155MP0004043_abnormal_pH_regulation0.67887913
156MP0003635_abnormal_synaptic_transmissio0.67810945
157MP0000747_muscle_weakness0.67679730
158MP0000613_abnormal_salivary_gland0.67052807
159MP0002572_abnormal_emotion/affect_behav0.66713792
160MP0000383_abnormal_hair_follicle0.64961665
161MP0002075_abnormal_coat/hair_pigmentati0.61878477
162MP0003633_abnormal_nervous_system0.61110510
163MP0009384_cardiac_valve_regurgitation0.59193634
164MP0005623_abnormal_meninges_morphology0.58974723
165MP0010771_integument_phenotype0.58447171
166MP0002933_joint_inflammation0.56568286
167MP0003690_abnormal_glial_cell0.54964992
168MP0000579_abnormal_nail_morphology0.53549934
169MP0001664_abnormal_digestion0.53088938

Predicted human phenotypes

RankGene SetZ-score
1Segmental peripheral demyelination/remyelination (HP:0003481)9.91625926
2Impaired proprioception (HP:0010831)8.10700301
3Termporal pattern (HP:0011008)7.16388089
4Insidious onset (HP:0003587)7.16388089
5Peripheral hypomyelination (HP:0007182)6.24537510
6Action tremor (HP:0002345)6.00198453
7Upper limb muscle weakness (HP:0003484)5.66551767
8Steppage gait (HP:0003376)5.16010073
9Onion bulb formation (HP:0003383)4.96944747
10Increased CSF protein (HP:0002922)4.85455771
11Abnormal pupillary function (HP:0007686)4.52701402
12Sex reversal (HP:0012245)4.08153688
13Abnormal sex determination (HP:0012244)4.08153688
14Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.06486454
15Decreased number of large peripheral myelinated nerve fibers (HP:0003387)4.04014054
16Decreased motor nerve conduction velocity (HP:0003431)3.53484486
17Abnormality of the vocal cords (HP:0008777)3.53481360
18Peripheral demyelination (HP:0011096)3.52565271
19Abnormality of the labia minora (HP:0012880)3.52365125
20Abnormal urine output (HP:0012590)3.33271685
21Foot dorsiflexor weakness (HP:0009027)3.30588896
22Hyperactive renin-angiotensin system (HP:0000841)3.30172266
23Hammertoe (HP:0001765)3.26273185
24Renal salt wasting (HP:0000127)3.14921681
25Postural tremor (HP:0002174)3.12646711
26Polydipsia (HP:0001959)3.03420617
27Abnormal drinking behavior (HP:0030082)3.03420617
28Hyperglycinemia (HP:0002154)3.02851666
29Abnormality of the foot musculature (HP:0001436)2.99909285
30Type I transferrin isoform profile (HP:0003642)2.96605113
31Parakeratosis (HP:0001036)2.94195036
32Abnormality of secondary sexual hair (HP:0009888)2.84740469
33Abnormality of the axillary hair (HP:0100134)2.84740469
34Aplasia/hypoplasia of the uterus (HP:0008684)2.82592764
35Abnormality of renal excretion (HP:0011036)2.82375060
36Bifid tongue (HP:0010297)2.82067317
37Hyperglycinuria (HP:0003108)2.69466181
38Tetany (HP:0001281)2.67815756
39Reduced antithrombin III activity (HP:0001976)2.67740739
40Pancreatic cysts (HP:0001737)2.63355793
41Intestinal atresia (HP:0011100)2.62768822
42Hypoplasia of the uterus (HP:0000013)2.61577799
43Chronic hepatic failure (HP:0100626)2.61051638
44Metabolic alkalosis (HP:0200114)2.58113269
45Hepatoblastoma (HP:0002884)2.56957056
46Congenital stationary night blindness (HP:0007642)2.50091531
47Bilateral microphthalmos (HP:0007633)2.48672068
48Abnormality of renin-angiotensin system (HP:0000847)2.44369375
49Abnormality of midbrain morphology (HP:0002418)2.44237683
50Molar tooth sign on MRI (HP:0002419)2.44237683
51White forelock (HP:0002211)2.36986976
52Renal Fanconi syndrome (HP:0001994)2.35649510
53Patchy hypopigmentation of hair (HP:0011365)2.34912106
54Glycosuria (HP:0003076)2.32282608
55Abnormality of urine glucose concentration (HP:0011016)2.32282608
56Pendular nystagmus (HP:0012043)2.31165937
57Spontaneous abortion (HP:0005268)2.29596361
58Abolished electroretinogram (ERG) (HP:0000550)2.28733953
59Proximal tubulopathy (HP:0000114)2.25296868
60Acute encephalopathy (HP:0006846)2.25014739
61Abnormality of the renal cortex (HP:0011035)2.24530538
62True hermaphroditism (HP:0010459)2.24311283
63Generalized aminoaciduria (HP:0002909)2.24189610
64Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23492564
65Abnormality of cells of the erythroid lineage (HP:0012130)2.23071521
66Vaginal atresia (HP:0000148)2.23045020
67Hypothermia (HP:0002045)2.21870540
68Abnormality of glycine metabolism (HP:0010895)2.21522957
69Abnormality of serine family amino acid metabolism (HP:0010894)2.21522957
70Abnormality of the renal medulla (HP:0100957)2.20680164
71Alkalosis (HP:0001948)2.20658461
72Abnormal auditory evoked potentials (HP:0006958)2.19220621
73Genital tract atresia (HP:0001827)2.18389637
74Aplasia cutis congenita (HP:0001057)2.15418370
75Nephrogenic diabetes insipidus (HP:0009806)2.12530855
76Pancreatic fibrosis (HP:0100732)2.12361572
77Increased hepatocellular lipid droplets (HP:0006565)2.11149769
78Keratoconus (HP:0000563)2.10768348
79Increased corneal curvature (HP:0100692)2.10768348
80Thyroid-stimulating hormone excess (HP:0002925)2.08666352
81Absent eyebrow (HP:0002223)2.06017167
82Medial flaring of the eyebrow (HP:0010747)2.04790593
83Progressive sensorineural hearing impairment (HP:0000408)2.03396472
84Abnormal number of erythroid precursors (HP:0012131)2.03394370
85Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02384069
86Ulnar claw (HP:0001178)12.3334583
87Renal cortical cysts (HP:0000803)1.99289343
88* Abnormality of magnesium homeostasis (HP:0004921)1.99275419
89Reticulocytopenia (HP:0001896)1.98646586
90Hypobetalipoproteinemia (HP:0003563)1.97927000
91Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97765252
92Split foot (HP:0001839)1.95739844
93Hypokalemia (HP:0002900)1.94979335
94Acute necrotizing encephalopathy (HP:0006965)1.94356733
95Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93154778
96Hypokalemic alkalosis (HP:0001949)1.91589108
97Labial hypoplasia (HP:0000066)1.91300025
98Renal hypoplasia (HP:0000089)1.91014758
99Abnormal protein glycosylation (HP:0012346)1.90420135
100Abnormal glycosylation (HP:0012345)1.90420135
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90420135
102Abnormal protein N-linked glycosylation (HP:0012347)1.90420135
103Nonprogressive disorder (HP:0003680)1.88318200
104Increased circulating renin level (HP:0000848)1.88146662
105Type II lissencephaly (HP:0007260)1.87827529
106Colon cancer (HP:0003003)1.87760002
107Broad-based gait (HP:0002136)1.87507503
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87460729
109Abnormality of alanine metabolism (HP:0010916)1.87460729
110Hyperalaninemia (HP:0003348)1.87460729
111Atrophic scars (HP:0001075)1.87307813
112* Hypomagnesemia (HP:0002917)1.87114718
113Enlarged kidneys (HP:0000105)1.86049561
114Cerebellar dysplasia (HP:0007033)1.85951410
115Gastrointestinal atresia (HP:0002589)1.85772501
116Bicornuate uterus (HP:0000813)1.84362908
117Abnormality of serum amino acid levels (HP:0003112)1.84010121
118Gout (HP:0001997)1.82615594
119Anophthalmia (HP:0000528)1.82074620
120Nephronophthisis (HP:0000090)1.81890010
121Hypoplastic female external genitalia (HP:0012815)1.81493970
122Retinal dysplasia (HP:0007973)1.81354158
123Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80457472
124Retinal atrophy (HP:0001105)1.80292150
125Abnormality of renal resorption (HP:0011038)1.77940470
126Attenuation of retinal blood vessels (HP:0007843)1.77212071
127Concave nail (HP:0001598)1.76988340
128Choanal stenosis (HP:0000452)1.76831633
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.75412608
130Absent/shortened dynein arms (HP:0200106)1.75412608
131Congenital primary aphakia (HP:0007707)1.75263625
132Gait imbalance (HP:0002141)1.74491484
133Gonadal dysgenesis (HP:0000133)1.74344554
134Septo-optic dysplasia (HP:0100842)1.73426499
1353-Methylglutaconic aciduria (HP:0003535)1.73302170
136Aqueductal stenosis (HP:0002410)1.72629743
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71602034
138Tubular atrophy (HP:0000092)1.71356919
139Absent septum pellucidum (HP:0001331)1.70868348
140Increased CSF lactate (HP:0002490)1.69846090
141Cystic liver disease (HP:0006706)1.68295989
142Facial cleft (HP:0002006)1.67715978
143Cupped ear (HP:0000378)1.67336476
144Macrocytic anemia (HP:0001972)1.67213566
145Esophageal atresia (HP:0002032)1.66641881
146Hypoglycemic coma (HP:0001325)1.66458741
147Scrotal hypoplasia (HP:0000046)1.65785033
148Abnormal mitochondria in muscle tissue (HP:0008316)1.65756380
149Prolonged partial thromboplastin time (HP:0003645)1.65427228
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.64669064
151* Hypercalciuria (HP:0002150)1.64357633
152Lipid accumulation in hepatocytes (HP:0006561)1.63005641
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.62940280
154Abnormality of the pupil (HP:0000615)1.62519022
155Intrahepatic cholestasis (HP:0001406)1.60970067
156Hepatocellular necrosis (HP:0001404)1.58521900
157Nasolacrimal duct obstruction (HP:0000579)1.58356864
158Amelogenesis imperfecta (HP:0000705)1.58245421
159Aplasia/Hypoplasia of the sacrum (HP:0008517)1.58175708
160Mitochondrial inheritance (HP:0001427)1.56898748
161Abnormality of the septum pellucidum (HP:0007375)1.56387719
162Lissencephaly (HP:0001339)1.55934847
163Optic disc pallor (HP:0000543)1.55736648
164Abnormal ciliary motility (HP:0012262)1.53139757
165Optic nerve hypoplasia (HP:0000609)1.52296960
166Alacrima (HP:0000522)1.51544418
167Distal sensory impairment (HP:0002936)1.50461580
168Exertional dyspnea (HP:0002875)1.49934277
169Decreased central vision (HP:0007663)1.48796928
170Fragile skin (HP:0001030)1.47976641
171Kyphoscoliosis (HP:0002751)1.46179545
172Short tibia (HP:0005736)1.44452250
173Conical tooth (HP:0000698)1.43180681
174Flat occiput (HP:0005469)1.42161226
175Congenital ichthyosiform erythroderma (HP:0007431)1.41888354
176Focal motor seizures (HP:0011153)1.41094933
177Polyuria (HP:0000103)1.40900573
178Stomatitis (HP:0010280)1.40883381
179Male pseudohermaphroditism (HP:0000037)1.40630747
180Hyperaldosteronism (HP:0000859)1.39066335
181Anhidrosis (HP:0000970)1.38568016
182Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.37704243
183Abnormality of chloride homeostasis (HP:0011422)1.37430765
184Abnormal rod and cone electroretinograms (HP:0008323)1.37004884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.33967014
2CASK4.73323795
3IRAK23.36945278
4MKNK22.98961586
5STK392.96964106
6MUSK2.89318829
7IRAK12.66930117
8FRK2.66490059
9ZAK2.62123993
10STK162.58182553
11TRIM282.41292513
12PDK22.39652577
13OXSR12.33354183
14EIF2AK32.18224192
15FGFR22.14890059
16BLK2.05089959
17TLK12.04794287
18PINK11.97762206
19WNK41.90278976
20FES1.86059151
21MKNK11.81475589
22MAP4K21.81152677
23CDK191.74880424
24NLK1.67791781
25BCKDK1.65554266
26IRAK41.64050028
27IRAK31.62863415
28MST41.59936542
29NME21.56779063
30BMPR1B1.50524826
31YES11.48649313
32PBK1.48020274
33UHMK11.34075837
34CLK11.33198068
35BCR1.29984024
36PKN11.26115643
37PLK31.23703471
38MAPK131.23453153
39ADRBK21.18004922
40EPHB11.15915001
41TSSK61.15542826
42MAPKAPK51.14392938
43TEC1.13833498
44FLT31.13506245
45STK38L1.13310565
46VRK21.12753169
47MAPK151.12233189
48TTK1.11207884
49WNK31.11103805
50EIF2AK21.09160681
51ACVR1B1.09120294
52PLK41.05645531
53MAP2K71.02864799
54MARK21.00722775
55CAMKK20.99172558
56PRPF4B0.93151822
57PLK20.91592943
58PRKD20.91215185
59TGFBR10.90070906
60MAP3K40.89917404
61VRK10.89731809
62BUB10.87943958
63GRK10.87357100
64AKT30.84881215
65PRKCG0.83247715
66KIT0.82578752
67GRK70.82049725
68FGFR10.81475938
69SRPK10.76943691
70CDK30.76090520
71NEK10.75624090
72MAP3K120.75526747
73CAMK2B0.75509677
74CAMK10.75319503
75SGK20.74997202
76RIPK40.74971119
77INSRR0.73093275
78CSNK1G10.72012044
79WNK10.70420128
80SGK2230.69725313
81SGK4940.69725313
82PLK10.69167374
83ATR0.67946001
84FGR0.66015341
85PAK30.65911012
86PIM20.65494809
87CSNK1G30.64993160
88EPHA40.64617749
89DYRK20.64028900
90BRSK20.63004494
91CSNK1A10.62185595
92TXK0.59347838
93WEE10.58270343
94PRKCI0.58170751
95NEK60.57937351
96CSK0.57864209
97LYN0.57105198
98CSNK1A1L0.57051095
99TIE10.56443469
100BMPR20.55233711
101BTK0.54073458
102HIPK20.54027132
103PRKCE0.52449794
104TNK20.52178074
105STK30.51859188
106CAMK2A0.51412288
107BRD40.51103566
108ADRBK10.50848468
109LCK0.50691297
110CAMK2D0.49381290
111ROCK20.49252374
112FER0.48479386
113CDC70.48442212
114ATM0.47979484
115CSNK1D0.47024600
116MST1R0.44672376
117MAP2K20.43661214
118MINK10.43450319
119CSNK1E0.42790738
120DYRK1A0.42455027
121CSNK1G20.42293852
122ERBB20.42130358
123MAPK40.40991951
124PRKCQ0.39719920
125LIMK10.38049525
126TYRO30.37868985
127NTRK30.37433076
128CHEK20.36711290
129ERBB40.36555018
130RPS6KA40.36380905
131PRKCZ0.35910592
132PRKACA0.35009307
133DYRK30.34149324
134FYN0.34145180
135MET0.33499685
136GRK50.32969239
137PIK3CG0.32648657
138CDK50.32391808
139NME10.32321654
140GSK3A0.32204918
141DAPK20.32014563
142RPS6KA50.31898806
143PRKG10.31826455
144IKBKB0.31362557
145PHKG10.30972332
146PHKG20.30972332
147MARK10.30564259
148SIK30.30162726
149CSNK2A10.30013650
150PRKACB0.29755908
151MAP3K140.29428372
152MATK0.28970809
153PRKAA10.28393985
154NUAK10.26571568
155CAMK2G0.26515214
156NEK20.26406550
157PNCK0.25712194

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.54966592
2Protein export_Homo sapiens_hsa030603.05354153
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.61593960
4Oxidative phosphorylation_Homo sapiens_hsa001902.52038847
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45215201
6Propanoate metabolism_Homo sapiens_hsa006402.38739734
7Sphingolipid metabolism_Homo sapiens_hsa006002.37039848
8Fatty acid elongation_Homo sapiens_hsa000622.36935249
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33268025
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.18417188
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15033189
12Ether lipid metabolism_Homo sapiens_hsa005652.09710587
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.07104604
14Proteasome_Homo sapiens_hsa030502.05898650
15Butanoate metabolism_Homo sapiens_hsa006502.00282176
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99982265
17Phototransduction_Homo sapiens_hsa047441.98291951
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.97600656
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.92762113
20Fat digestion and absorption_Homo sapiens_hsa049751.92192231
21* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.86029349
22Selenocompound metabolism_Homo sapiens_hsa004501.72346857
23Steroid biosynthesis_Homo sapiens_hsa001001.71738538
24Nitrogen metabolism_Homo sapiens_hsa009101.69390763
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66550235
26Arachidonic acid metabolism_Homo sapiens_hsa005901.64275405
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.63154043
28Other glycan degradation_Homo sapiens_hsa005111.57260978
29Parkinsons disease_Homo sapiens_hsa050121.57194524
30Alzheimers disease_Homo sapiens_hsa050101.57162463
31Tryptophan metabolism_Homo sapiens_hsa003801.56280480
32ECM-receptor interaction_Homo sapiens_hsa045121.50783119
33Axon guidance_Homo sapiens_hsa043601.49926121
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49794475
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43468045
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42862463
37One carbon pool by folate_Homo sapiens_hsa006701.42393283
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41140769
39Pyruvate metabolism_Homo sapiens_hsa006201.41081539
40Nicotine addiction_Homo sapiens_hsa050331.40115121
41Peroxisome_Homo sapiens_hsa041461.36661502
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35477730
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33217949
44Fatty acid degradation_Homo sapiens_hsa000711.28276471
45Serotonergic synapse_Homo sapiens_hsa047261.27731726
46Non-homologous end-joining_Homo sapiens_hsa034501.27482807
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.27064273
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21847851
49Fatty acid metabolism_Homo sapiens_hsa012121.21325497
50Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21055292
51Fanconi anemia pathway_Homo sapiens_hsa034601.19646204
52RNA degradation_Homo sapiens_hsa030181.18637834
53Hematopoietic cell lineage_Homo sapiens_hsa046401.17898532
54beta-Alanine metabolism_Homo sapiens_hsa004101.14507804
55Caffeine metabolism_Homo sapiens_hsa002321.13896379
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13182024
57Taste transduction_Homo sapiens_hsa047421.11109590
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10743678
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09389114
60Linoleic acid metabolism_Homo sapiens_hsa005911.07572870
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03964044
62Long-term depression_Homo sapiens_hsa047301.03923500
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03858058
64Glutamatergic synapse_Homo sapiens_hsa047241.03705203
65Huntingtons disease_Homo sapiens_hsa050161.03651778
66Protein digestion and absorption_Homo sapiens_hsa049741.03601571
67Base excision repair_Homo sapiens_hsa034101.01751374
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00041902
69Homologous recombination_Homo sapiens_hsa034400.99368695
70Graft-versus-host disease_Homo sapiens_hsa053320.97878135
71Autoimmune thyroid disease_Homo sapiens_hsa053200.96614750
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95377253
73Chemical carcinogenesis_Homo sapiens_hsa052040.95370237
74Mismatch repair_Homo sapiens_hsa034300.94977042
75Asthma_Homo sapiens_hsa053100.94787149
76Histidine metabolism_Homo sapiens_hsa003400.94254847
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93161659
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89818764
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89492593
80RNA polymerase_Homo sapiens_hsa030200.87267344
81N-Glycan biosynthesis_Homo sapiens_hsa005100.85662128
82Malaria_Homo sapiens_hsa051440.85536598
83RNA transport_Homo sapiens_hsa030130.84228533
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83970712
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83358163
86Allograft rejection_Homo sapiens_hsa053300.81420883
87Morphine addiction_Homo sapiens_hsa050320.80674423
88Primary immunodeficiency_Homo sapiens_hsa053400.79193173
89African trypanosomiasis_Homo sapiens_hsa051430.76629432
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76300754
91Arginine biosynthesis_Homo sapiens_hsa002200.75944559
92Hedgehog signaling pathway_Homo sapiens_hsa043400.74828574
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74732298
94Lysine degradation_Homo sapiens_hsa003100.74456059
95Rheumatoid arthritis_Homo sapiens_hsa053230.71107155
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69116997
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.67555674
98Basal transcription factors_Homo sapiens_hsa030220.65943567
99Vitamin digestion and absorption_Homo sapiens_hsa049770.65540153
100GABAergic synapse_Homo sapiens_hsa047270.62485831
101Vitamin B6 metabolism_Homo sapiens_hsa007500.61467806
102Cardiac muscle contraction_Homo sapiens_hsa042600.61419317
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60860604
104Alcoholism_Homo sapiens_hsa050340.60368440
105Ras signaling pathway_Homo sapiens_hsa040140.60129836
106PPAR signaling pathway_Homo sapiens_hsa033200.58933573
107Regulation of autophagy_Homo sapiens_hsa041400.57643415
108Systemic lupus erythematosus_Homo sapiens_hsa053220.57052703
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.56452702
110Calcium signaling pathway_Homo sapiens_hsa040200.55993724
111Spliceosome_Homo sapiens_hsa030400.55108086
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53957111
113Complement and coagulation cascades_Homo sapiens_hsa046100.53095797
114Salivary secretion_Homo sapiens_hsa049700.52350244
115DNA replication_Homo sapiens_hsa030300.51688005
116Carbon metabolism_Homo sapiens_hsa012000.51617776
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50813405
118Collecting duct acid secretion_Homo sapiens_hsa049660.49875418
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47762305
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47576778
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47056697
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47051677
123Gastric acid secretion_Homo sapiens_hsa049710.46551235
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.46402410
125Phagosome_Homo sapiens_hsa041450.46084997
126Biosynthesis of amino acids_Homo sapiens_hsa012300.45885217
127Hippo signaling pathway_Homo sapiens_hsa043900.44502057
128Amoebiasis_Homo sapiens_hsa051460.44380685
129Mineral absorption_Homo sapiens_hsa049780.43099871
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42926206
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.41957261
132Purine metabolism_Homo sapiens_hsa002300.41850744
133Wnt signaling pathway_Homo sapiens_hsa043100.41834301
134Cholinergic synapse_Homo sapiens_hsa047250.40889920
135Basal cell carcinoma_Homo sapiens_hsa052170.40651787
136Arginine and proline metabolism_Homo sapiens_hsa003300.39967577
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.39390870
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38852408
139Sulfur metabolism_Homo sapiens_hsa009200.38433187
140Metabolic pathways_Homo sapiens_hsa011000.37684225
141Melanogenesis_Homo sapiens_hsa049160.37655195
142Pancreatic secretion_Homo sapiens_hsa049720.37600044
143Retinol metabolism_Homo sapiens_hsa008300.35555440
144Pertussis_Homo sapiens_hsa051330.35300191
145Ovarian steroidogenesis_Homo sapiens_hsa049130.35171050
146Glutathione metabolism_Homo sapiens_hsa004800.35163563
147Nucleotide excision repair_Homo sapiens_hsa034200.34844758
148Circadian entrainment_Homo sapiens_hsa047130.34049997
149Glycerolipid metabolism_Homo sapiens_hsa005610.33947577
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33670125
151Renin-angiotensin system_Homo sapiens_hsa046140.33501027
152Pyrimidine metabolism_Homo sapiens_hsa002400.33137929

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