CLDN12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.71759508
2L-phenylalanine catabolic process (GO:0006559)6.71759508
3L-phenylalanine metabolic process (GO:0006558)6.43345953
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.43345953
5aromatic amino acid family catabolic process (GO:0009074)5.83168612
6bile acid biosynthetic process (GO:0006699)5.27823388
7alpha-linolenic acid metabolic process (GO:0036109)5.25237636
8glyoxylate metabolic process (GO:0046487)5.21483211
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.16475560
10kynurenine metabolic process (GO:0070189)5.14971225
11tryptophan catabolic process (GO:0006569)5.05937527
12indole-containing compound catabolic process (GO:0042436)5.05937527
13indolalkylamine catabolic process (GO:0046218)5.05937527
14negative regulation of fibrinolysis (GO:0051918)5.04307821
15cysteine metabolic process (GO:0006534)5.03231974
16tryptophan metabolic process (GO:0006568)4.83572600
17sulfur amino acid catabolic process (GO:0000098)4.74459278
18lysine metabolic process (GO:0006553)4.71569372
19lysine catabolic process (GO:0006554)4.71569372
20regulation of fibrinolysis (GO:0051917)4.68326494
21high-density lipoprotein particle remodeling (GO:0034375)4.67601536
22urea metabolic process (GO:0019627)4.67110385
23urea cycle (GO:0000050)4.67110385
24serine family amino acid catabolic process (GO:0009071)4.51731710
25homocysteine metabolic process (GO:0050667)4.49891640
26bile acid metabolic process (GO:0008206)4.48866488
27protein carboxylation (GO:0018214)4.48039143
28peptidyl-glutamic acid carboxylation (GO:0017187)4.48039143
29regulation of protein activation cascade (GO:2000257)4.43239963
30glutamate metabolic process (GO:0006536)4.35494449
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.34511184
32complement activation, alternative pathway (GO:0006957)4.33204822
33tyrosine metabolic process (GO:0006570)4.28846847
34aromatic amino acid family metabolic process (GO:0009072)4.27049241
35dicarboxylic acid biosynthetic process (GO:0043650)4.26166619
36cellular ketone body metabolic process (GO:0046950)4.24578196
37nitrogen cycle metabolic process (GO:0071941)4.21130407
38alpha-amino acid catabolic process (GO:1901606)4.17549272
39reverse cholesterol transport (GO:0043691)4.15716232
40regulation of complement activation (GO:0030449)4.13955998
41amino-acid betaine metabolic process (GO:0006577)4.12761767
42cellular glucuronidation (GO:0052695)4.09541311
43acylglycerol homeostasis (GO:0055090)4.08058465
44triglyceride homeostasis (GO:0070328)4.08058465
45coenzyme catabolic process (GO:0009109)3.95881457
46cellular amino acid catabolic process (GO:0009063)3.92203611
47negative regulation of sterol transport (GO:0032372)3.90036205
48negative regulation of cholesterol transport (GO:0032375)3.90036205
49regulation of triglyceride catabolic process (GO:0010896)3.89695140
50macromolecular complex remodeling (GO:0034367)3.89067724
51plasma lipoprotein particle remodeling (GO:0034369)3.89067724
52protein-lipid complex remodeling (GO:0034368)3.89067724
53cellular modified amino acid catabolic process (GO:0042219)3.86989754
54regulation of cholesterol esterification (GO:0010872)3.81392717
55serine family amino acid metabolic process (GO:0009069)3.80822200
56glycine metabolic process (GO:0006544)3.79675996
57drug catabolic process (GO:0042737)3.77944520
58regulation of cholesterol homeostasis (GO:2000188)3.77778909
59ketone body metabolic process (GO:1902224)3.73563029
60aspartate family amino acid catabolic process (GO:0009068)3.71193983
61regulation of bile acid biosynthetic process (GO:0070857)3.65606052
62bile acid and bile salt transport (GO:0015721)3.64481802
63serine family amino acid biosynthetic process (GO:0009070)3.62572493
64short-chain fatty acid metabolic process (GO:0046459)3.61294556
65plasma lipoprotein particle clearance (GO:0034381)3.60822289
66benzene-containing compound metabolic process (GO:0042537)3.60536689
67uronic acid metabolic process (GO:0006063)3.59538149
68glucuronate metabolic process (GO:0019585)3.59538149
69indolalkylamine metabolic process (GO:0006586)3.58182559
702-oxoglutarate metabolic process (GO:0006103)3.49674329
71epoxygenase P450 pathway (GO:0019373)3.49309541
72acetyl-CoA metabolic process (GO:0006084)3.47377941
73phospholipid efflux (GO:0033700)3.47281998
74ethanol oxidation (GO:0006069)3.47196281
75cholesterol efflux (GO:0033344)3.47191606
76fibrinolysis (GO:0042730)3.46556210
77carboxylic acid catabolic process (GO:0046395)3.37918312
78organic acid catabolic process (GO:0016054)3.37918312
79exogenous drug catabolic process (GO:0042738)3.34974506
80positive regulation of fatty acid beta-oxidation (GO:0032000)3.34936249
81drug transmembrane transport (GO:0006855)3.34218317
82imidazole-containing compound metabolic process (GO:0052803)3.33083417
83arginine metabolic process (GO:0006525)3.31944892
84regulation of plasminogen activation (GO:0010755)3.30525511
85amine catabolic process (GO:0009310)3.30431425
86cellular biogenic amine catabolic process (GO:0042402)3.30431425
87phospholipid homeostasis (GO:0055091)3.26344978
88positive regulation of lipid catabolic process (GO:0050996)3.23739589
89negative regulation of lipase activity (GO:0060192)3.21357763
90urate metabolic process (GO:0046415)3.20917492
91dicarboxylic acid catabolic process (GO:0043649)3.17761249
92monocarboxylic acid catabolic process (GO:0072329)3.14900027
93plasma lipoprotein particle assembly (GO:0034377)3.13349148
94fatty acid oxidation (GO:0019395)3.12991729
95cytolysis (GO:0019835)3.12577761
96cholesterol homeostasis (GO:0042632)3.12194926
97drug metabolic process (GO:0017144)3.11675993
98sterol homeostasis (GO:0055092)3.11499224
99fatty acid beta-oxidation (GO:0006635)3.10073066
100lipoprotein metabolic process (GO:0042157)3.09059147
101intestinal cholesterol absorption (GO:0030299)2.90935793
102COPII vesicle coating (GO:0048208)2.73566477
103bundle of His cell to Purkinje myocyte communication (GO:0086069)2.58455608
104water-soluble vitamin biosynthetic process (GO:0042364)2.54281877
105nucleotide-sugar biosynthetic process (GO:0009226)2.50863898
106regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.49661050
107L-serine metabolic process (GO:0006563)2.45343195
108paraxial mesoderm development (GO:0048339)2.43371621
109UDP-N-acetylglucosamine metabolic process (GO:0006047)2.30284007
110intestinal absorption (GO:0050892)2.30088536
111cholesterol biosynthetic process (GO:0006695)2.28946063
112polyketide metabolic process (GO:0030638)2.27579935
113doxorubicin metabolic process (GO:0044598)2.27579935
114daunorubicin metabolic process (GO:0044597)2.27579935
115COPI coating of Golgi vesicle (GO:0048205)2.26475722
116Golgi transport vesicle coating (GO:0048200)2.26475722
117magnesium ion transport (GO:0015693)2.24311819
118peptidyl-cysteine modification (GO:0018198)2.22071458
119regulation of hexokinase activity (GO:1903299)2.20062700
120regulation of glucokinase activity (GO:0033131)2.20062700
121regulation of cofactor metabolic process (GO:0051193)2.15351915
122regulation of coenzyme metabolic process (GO:0051196)2.15351915
123cullin deneddylation (GO:0010388)2.15116764
124regulation of acyl-CoA biosynthetic process (GO:0050812)2.12795996
125branched-chain amino acid catabolic process (GO:0009083)2.12232279
126regulation of sulfur metabolic process (GO:0042762)2.11731592
127sterol biosynthetic process (GO:0016126)2.09550451
128zinc ion transport (GO:0006829)2.09047522
129L-serine transport (GO:0015825)2.08962036
130nonmotile primary cilium assembly (GO:0035058)2.08517520
131presynaptic membrane assembly (GO:0097105)2.07672177
132anterior/posterior axis specification, embryo (GO:0008595)2.06185990
133tRNA aminoacylation for protein translation (GO:0006418)2.05073037
134aminoglycoside antibiotic metabolic process (GO:0030647)2.02662336
135regulation of keratinocyte proliferation (GO:0010837)2.02441813
136amino acid activation (GO:0043038)2.01899134
137tRNA aminoacylation (GO:0043039)2.01899134
138L-methionine salvage (GO:0071267)2.01789293
139L-methionine biosynthetic process (GO:0071265)2.01789293
140amino acid salvage (GO:0043102)2.01789293
141embryonic foregut morphogenesis (GO:0048617)2.01567058
142S-adenosylmethionine metabolic process (GO:0046500)2.01497266
143DNA double-strand break processing (GO:0000729)2.01417633
144cobalamin metabolic process (GO:0009235)2.00784069
145somite rostral/caudal axis specification (GO:0032525)1.99027889
146membrane budding (GO:0006900)1.97194958
147protein deneddylation (GO:0000338)1.96818027
148C4-dicarboxylate transport (GO:0015740)1.95444711
149tricarboxylic acid cycle (GO:0006099)1.93799531
150primary alcohol catabolic process (GO:0034310)1.92937868
151positive regulation of glycolytic process (GO:0045821)1.92036361
152lipid particle organization (GO:0034389)1.89427739
153vascular smooth muscle contraction (GO:0014829)1.88861894
154L-methionine biosynthetic process from methylthioadenosine (GO:0019509)1.88593527
155metaphase plate congression (GO:0051310)1.88399995
156desmosome organization (GO:0002934)1.88325391
157cell fate commitment involved in formation of primary germ layer (GO:0060795)1.87826808
158gap junction assembly (GO:0016264)1.87041054
159nucleotide transmembrane transport (GO:1901679)1.86903214
160dorsal/ventral axis specification (GO:0009950)1.85735930
161very-low-density lipoprotein particle assembly (GO:0034379)1.84592832
162intestinal epithelial cell development (GO:0060576)1.84121371
163biotin metabolic process (GO:0006768)1.81952739
164negative regulation of keratinocyte proliferation (GO:0010839)1.81069786
165proteasome assembly (GO:0043248)1.80566065
166glutamine metabolic process (GO:0006541)1.78957037
167mitotic metaphase plate congression (GO:0007080)1.77709762
168kidney morphogenesis (GO:0060993)1.77045451
169ectodermal placode formation (GO:0060788)1.76436920
170terpenoid biosynthetic process (GO:0016114)1.75588107
171nucleotide-sugar metabolic process (GO:0009225)1.73307069
172artery smooth muscle contraction (GO:0014824)1.73074564
173isoprenoid biosynthetic process (GO:0008299)1.72640762
174response to nitrosative stress (GO:0051409)1.71946904
175calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)1.71537220
176establishment of melanosome localization (GO:0032401)1.71475088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.38088797
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.65044549
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.63326207
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.30826950
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.81087882
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.24538242
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.72973925
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.68685051
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.41388823
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.64952550
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.56067954
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46000169
13CLOCK_20551151_ChIP-Seq_293T_Human2.33309440
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23039996
15* AR_21909140_ChIP-Seq_LNCAP_Human1.93309211
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90002210
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.89559379
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87684945
19FUS_26573619_Chip-Seq_HEK293_Human1.87568843
20PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.83795103
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.81387288
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73158623
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68414654
24P300_19829295_ChIP-Seq_ESCs_Human1.67795376
25IGF1R_20145208_ChIP-Seq_DFB_Human1.67758615
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66688470
27VDR_22108803_ChIP-Seq_LS180_Human1.66102262
28EWS_26573619_Chip-Seq_HEK293_Human1.64142370
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63855295
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62904477
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.60923015
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.60510025
33ELK1_19687146_ChIP-ChIP_HELA_Human1.58653928
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58186448
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56899265
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.56296053
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51886801
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48694873
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47610764
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45237808
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45164515
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41806760
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.38142195
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34724829
45* HNF4A_19822575_ChIP-Seq_HepG2_Human1.33338274
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.32035424
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31954438
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.31614089
49* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30585249
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27108014
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25553880
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25553880
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.24184543
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.22951877
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21703129
56ZNF263_19887448_ChIP-Seq_K562_Human1.21282297
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20462005
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19496950
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.16728069
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15714834
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15298029
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12826242
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11516452
64TP53_18474530_ChIP-ChIP_U2OS_Human1.09862067
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09689027
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09526621
67GATA1_22025678_ChIP-Seq_K562_Human1.09482928
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.09106285
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08850239
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08743265
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.08693842
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08257725
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.08071874
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07997488
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.07700671
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06623468
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05928073
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05772204
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05527024
80CBP_20019798_ChIP-Seq_JUKART_Human1.05527024
81CDX2_22108803_ChIP-Seq_LS180_Human1.05250643
82NANOG_16153702_ChIP-ChIP_HESCs_Human1.05072096
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05025385
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04861430
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03327051
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02329353
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02074007
88STAT3_23295773_ChIP-Seq_U87_Human1.00320346
89* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00108275
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99811769
91AR_25329375_ChIP-Seq_VCAP_Human0.98927192
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98209838
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97563832
94TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96960176
95HTT_18923047_ChIP-ChIP_STHdh_Human0.96806361
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96599822
97TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96494588
98ERG_21242973_ChIP-ChIP_JURKAT_Human0.96119273
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96024880
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.95947932
101PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95925036
102CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95404376
103GBX2_23144817_ChIP-Seq_PC3_Human0.93534431
104* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92552042
105FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92359873
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.91508478
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91299160
108EST1_17652178_ChIP-ChIP_JURKAT_Human0.90704741
109* SOX17_20123909_ChIP-Seq_XEN_Mouse0.89140102
110YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88483577
111* ER_23166858_ChIP-Seq_MCF-7_Human0.87599982
112BCAT_22108803_ChIP-Seq_LS180_Human0.86902860
113SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86824110
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86678561
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86426325
116E2F1_18555785_Chip-Seq_ESCs_Mouse0.86233833
117P53_22387025_ChIP-Seq_ESCs_Mouse0.86161582
118RUNX2_22187159_ChIP-Seq_PCA_Human0.86148846
119GATA4_25053715_ChIP-Seq_YYC3_Human0.85370304
120ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84709018
121* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83859125
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.83289419
123* EP300_21415370_ChIP-Seq_HL-1_Mouse0.81618221
124PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81504899
125SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.79789735
126TAF15_26573619_Chip-Seq_HEK293_Human0.74720197
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.74606078
128AR_21572438_ChIP-Seq_LNCaP_Human0.74175562
129* SOX2_21211035_ChIP-Seq_LN229_Gbm0.72377771
130SMAD4_21741376_ChIP-Seq_HESCs_Human0.71060061
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.69390512
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.68958076
133CBP_21632823_ChIP-Seq_H3396_Human0.67672746
134* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67443802
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.67359075
136FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67068283
137* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66668560
138RXRA_24833708_ChIP-Seq_LIVER_Mouse0.66562069
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.66342822
140MTF2_20144788_ChIP-Seq_MESCs_Mouse0.66340363
141SOX2_20726797_ChIP-Seq_SW620_Human0.66267296
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65130536
143BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.64842844
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.63516949
145ZNF274_21170338_ChIP-Seq_K562_Hela0.62043604
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.60026313
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.59504504
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.59295604
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.58477860
150FOXM1_26456572_ChIP-Seq_MCF-7_Human0.58186586
151CTBP1_25329375_ChIP-Seq_LNCAP_Human0.57818020
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.57792841
153TP63_23658742_ChIP-Seq_EP156T_Human0.57712249
154SMAD4_21799915_ChIP-Seq_A2780_Human0.57604667
155HIF1A_21447827_ChIP-Seq_MCF-7_Human0.57550011
156AR_19668381_ChIP-Seq_PC3_Human0.57480434
157GATA3_24758297_ChIP-Seq_MCF-7_Human0.57070451
158CJUN_26792858_Chip-Seq_BT549_Human0.56702677
159DROSHA_22980978_ChIP-Seq_HELA_Human0.56435514
160RARB_27405468_Chip-Seq_BRAIN_Mouse0.55332480
161CDX2_19796622_ChIP-Seq_MESCs_Mouse0.54786076
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.54728513
163* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.54410202
164AHR_22903824_ChIP-Seq_MCF-7_Human0.54179450
165RXR_22108803_ChIP-Seq_LS180_Human0.52895696
166TCF4_22108803_ChIP-Seq_LS180_Human0.52727650
167GATA6_25053715_ChIP-Seq_YYC3_Human0.52700549
168TBX20_22328084_ChIP-Seq_HEART_Mouse0.52665853
169TBX20_22080862_ChIP-Seq_HEART_Mouse0.52665853
170SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.52175195

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.60534143
2MP0005360_urolithiasis6.95023312
3MP0005085_abnormal_gallbladder_physiolo5.85386065
4MP0005365_abnormal_bile_salt5.54281985
5MP0008875_abnormal_xenobiotic_pharmacok4.66309319
6MP0003252_abnormal_bile_duct3.93380704
7MP0003806_abnormal_nucleotide_metabolis3.54280373
8MP0010329_abnormal_lipoprotein_level3.22295880
9MP0003941_abnormal_skin_development3.06521385
10MP0003195_calcinosis2.88820880
11MP0005332_abnormal_amino_acid2.76589272
12MP0005083_abnormal_biliary_tract2.60872946
13MP0003890_abnormal_embryonic-extraembry2.57497885
14MP0001666_abnormal_nutrient_absorption2.51387508
15MP0009840_abnormal_foam_cell2.23914535
16MP0004019_abnormal_vitamin_homeostasis2.07148443
17MP0003122_maternal_imprinting1.94180388
18MP0003705_abnormal_hypodermis_morpholog1.91407652
19MP0002118_abnormal_lipid_homeostasis1.87653085
20MP0003868_abnormal_feces_composition1.87413831
21MP0000566_synostosis1.86693082
22MP0003718_maternal_effect1.82751560
23MP0000609_abnormal_liver_physiology1.71867856
24MP0008789_abnormal_olfactory_epithelium1.68655093
25MP0002138_abnormal_hepatobiliary_system1.68573025
26MP0003937_abnormal_limbs/digits/tail_de1.57599483
27MP0010678_abnormal_skin_adnexa1.54146444
28MP0005319_abnormal_enzyme/_coenzyme1.50603177
29MP0005499_abnormal_olfactory_system1.46417723
30MP0005394_taste/olfaction_phenotype1.46417723
31MP0003191_abnormal_cellular_cholesterol1.45391123
32MP0010352_gastrointestinal_tract_polyps1.44425819
33MP0003011_delayed_dark_adaptation1.40220719
34MP0000516_abnormal_urinary_system1.40052801
35MP0005367_renal/urinary_system_phenotyp1.40052801
36MP0002233_abnormal_nose_morphology1.39176276
37MP0002102_abnormal_ear_morphology1.35384410
38MP0001293_anophthalmia1.33932067
39MP0002938_white_spotting1.33656416
40MP0002822_catalepsy1.33340237
41MP0001529_abnormal_vocalization1.32897580
42MP0006072_abnormal_retinal_apoptosis1.30567885
43MP0004270_analgesia1.29778475
44MP0005584_abnormal_enzyme/coenzyme_acti1.26539452
45MP0009780_abnormal_chondrocyte_physiolo1.26523786
46MP0010234_abnormal_vibrissa_follicle1.25888928
47MP0009697_abnormal_copulation1.25685480
48MP0003121_genomic_imprinting1.23396735
49MP0001299_abnormal_eye_distance/1.21531052
50MP0002234_abnormal_pharynx_morphology1.21267832
51MP0001764_abnormal_homeostasis1.20198050
52MP0003123_paternal_imprinting1.18863162
53MP0002697_abnormal_eye_size1.18754120
54MP0005220_abnormal_exocrine_pancreas1.18693537
55MP0009643_abnormal_urine_homeostasis1.18445557
56MP0005248_abnormal_Harderian_gland1.18126146
57MP0008932_abnormal_embryonic_tissue1.14147326
58MP0003119_abnormal_digestive_system1.14054212
59MP0000647_abnormal_sebaceous_gland1.12502399
60MP0004957_abnormal_blastocyst_morpholog1.10493958
61MP0009053_abnormal_anal_canal1.09786861
62MP0004133_heterotaxia1.09007324
63MP0009384_cardiac_valve_regurgitation1.06560311
64MP0004043_abnormal_pH_regulation1.05610658
65MP0003315_abnormal_perineum_morphology1.05082633
66MP0005084_abnormal_gallbladder_morpholo1.03462181
67MP0000762_abnormal_tongue_morphology1.02931893
68MP0003755_abnormal_palate_morphology1.00751439
69MP0005253_abnormal_eye_physiology1.00099880
70MP0003567_abnormal_fetal_cardiomyocyte0.97535406
71MP0002084_abnormal_developmental_patter0.97372685
72MP0004215_abnormal_myocardial_fiber0.97281922
73MP0003329_amyloid_beta_deposits0.96792892
74MP0000383_abnormal_hair_follicle0.95522305
75MP0000778_abnormal_nervous_system0.95210978
76MP0003880_abnormal_central_pattern0.93184913
77MP0008877_abnormal_DNA_methylation0.91682490
78MP0001286_abnormal_eye_development0.89062098
79MP0006292_abnormal_olfactory_placode0.88224478
80MP0003693_abnormal_embryo_hatching0.88178095
81MP0000598_abnormal_liver_morphology0.87205238
82MP0002090_abnormal_vision0.86236755
83MP0005636_abnormal_mineral_homeostasis0.85735633
84MP0002078_abnormal_glucose_homeostasis0.85544021
85MP0003136_yellow_coat_color0.84217658
86MP0010368_abnormal_lymphatic_system0.84203043
87MP0006276_abnormal_autonomic_nervous0.83027029
88MP0005647_abnormal_sex_gland0.81179796
89MP0000604_amyloidosis0.80965804
90MP0004130_abnormal_muscle_cell0.80427351
91MP0001756_abnormal_urination0.80022121
92MP0002837_dystrophic_cardiac_calcinosis0.77601019
93MP0005408_hypopigmentation0.76967436
94MP0002638_abnormal_pupillary_reflex0.75893090
95MP0005391_vision/eye_phenotype0.75104040
96MP0000631_abnormal_neuroendocrine_gland0.74557602
97MP0005187_abnormal_penis_morphology0.73153276
98MP0002909_abnormal_adrenal_gland0.72552631
99MP0005551_abnormal_eye_electrophysiolog0.72423544
100MP0002876_abnormal_thyroid_physiology0.71535058
101MP0002751_abnormal_autonomic_nervous0.71241470
102MP0000462_abnormal_digestive_system0.71150651
103MP0001661_extended_life_span0.71150138
104MP0009046_muscle_twitch0.70996598
105MP0003385_abnormal_body_wall0.70456687
106MP0002085_abnormal_embryonic_tissue0.68612392
107MP0000538_abnormal_urinary_bladder0.68524485
108MP0006054_spinal_hemorrhage0.67885870
109MP0002928_abnormal_bile_duct0.67195038
110MP0008058_abnormal_DNA_repair0.66888179
111MP0003861_abnormal_nervous_system0.66132661
112MP0002111_abnormal_tail_morphology0.64932724
113MP0005380_embryogenesis_phenotype0.63757990
114MP0001672_abnormal_embryogenesis/_devel0.63757990
115MP0009642_abnormal_blood_homeostasis0.63078155
116MP0008007_abnormal_cellular_replicative0.63054849
117MP0000013_abnormal_adipose_tissue0.62909745
118MP0005376_homeostasis/metabolism_phenot0.61743890
119MP0002896_abnormal_bone_mineralization0.61393241
120MP0005535_abnormal_body_temperature0.60871145
121MP0003186_abnormal_redox_activity0.60656636
122MP0001984_abnormal_olfaction0.58315728
123MP0002254_reproductive_system_inflammat0.57989169
124MP0001177_atelectasis0.57042238
125MP0005266_abnormal_metabolism0.56440016
126MP0001944_abnormal_pancreas_morphology0.56132391
127MP0002168_other_aberrant_phenotype0.56106324
128MP0000639_abnormal_adrenal_gland0.55295699
129MP0005334_abnormal_fat_pad0.53765467
130MP0003690_abnormal_glial_cell0.53749290
131MP0003283_abnormal_digestive_organ0.53512603
132MP0004264_abnormal_extraembryonic_tissu0.52072335
133MP0002269_muscular_atrophy0.51808692
134MP0002971_abnormal_brown_adipose0.51669590
135MP0006036_abnormal_mitochondrial_physio0.50604282
136MP0005666_abnormal_adipose_tissue0.49639514
137MP0001324_abnormal_eye_pigmentation0.49164408
138MP0009672_abnormal_birth_weight0.48760327
139MP0001765_abnormal_ion_homeostasis0.48387346
140MP0005395_other_phenotype0.48105958
141MP0009763_increased_sensitivity_to0.47245779
142MP0003656_abnormal_erythrocyte_physiolo0.45429740
143MP0006035_abnormal_mitochondrial_morpho0.45350243
144MP0003953_abnormal_hormone_level0.45025727
145MP0000230_abnormal_systemic_arterial0.44070959
146MP0005448_abnormal_energy_balance0.43898271
147MP0004233_abnormal_muscle_weight0.42998611
148MP0000579_abnormal_nail_morphology0.42935973
149MP0005451_abnormal_body_composition0.42907864
150MP0004885_abnormal_endolymph0.42292389
151MP0004272_abnormal_basement_membrane0.41563686
152MP0005670_abnormal_white_adipose0.41349081
153MP0010030_abnormal_orbit_morphology0.40457748
154MP0002796_impaired_skin_barrier0.39475633
155MP0000537_abnormal_urethra_morphology0.38909662
156MP0009765_abnormal_xenobiotic_induced0.38188802
157MP0005595_abnormal_vascular_smooth0.37464653
158MP0002136_abnormal_kidney_physiology0.37456271
159MP0003942_abnormal_urinary_system0.36927116
160MP0003115_abnormal_respiratory_system0.36754248
161MP0009764_decreased_sensitivity_to0.35884919
162MP0000427_abnormal_hair_cycle0.35523320

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.58137279
2Deep venous thrombosis (HP:0002625)6.48039464
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.43825855
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.68937625
5Xanthomatosis (HP:0000991)5.67223105
6Hypobetalipoproteinemia (HP:0003563)5.65428134
7Prolonged partial thromboplastin time (HP:0003645)4.97027673
8Hyperlipoproteinemia (HP:0010980)4.56118077
9Hypolipoproteinemia (HP:0010981)4.38090017
10Complement deficiency (HP:0004431)4.25837548
11Hyperglycinemia (HP:0002154)4.24729519
12Ketosis (HP:0001946)4.24439629
13Hyperammonemia (HP:0001987)4.07779181
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.01190806
15Epidermoid cyst (HP:0200040)3.96219030
16Hypoalphalipoproteinemia (HP:0003233)3.90412982
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.87203738
18Abnormality of the common coagulation pathway (HP:0010990)3.83495590
19Abnormality of glycine metabolism (HP:0010895)3.75438947
20Abnormality of serine family amino acid metabolism (HP:0010894)3.75438947
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.73271367
22Hyperglycinuria (HP:0003108)3.67609015
23Hypoglycemic coma (HP:0001325)3.66939936
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.58590768
25Ketoacidosis (HP:0001993)3.53777768
26Fat malabsorption (HP:0002630)3.53428456
27Abnormality of the intrinsic pathway (HP:0010989)3.45566424
28Abnormality of methionine metabolism (HP:0010901)3.43799116
29Gout (HP:0001997)3.40587732
30Joint hemorrhage (HP:0005261)3.11210884
31Abnormality of complement system (HP:0005339)2.96966607
32Hypercholesterolemia (HP:0003124)2.96535135
33Skin nodule (HP:0200036)2.95994784
34Conjugated hyperbilirubinemia (HP:0002908)2.95820996
35Hepatocellular carcinoma (HP:0001402)2.87068249
36Delayed CNS myelination (HP:0002188)2.86797821
37Abnormality of purine metabolism (HP:0004352)2.79837777
38Abnormality of fatty-acid metabolism (HP:0004359)2.78462774
39Spastic diplegia (HP:0001264)2.76322903
40Abnormality of serum amino acid levels (HP:0003112)2.71200655
41Abnormality of nucleobase metabolism (HP:0010932)2.70769286
42Increased serum pyruvate (HP:0003542)2.70564475
43Hyperbilirubinemia (HP:0002904)2.64867662
44Cholecystitis (HP:0001082)2.61188102
45Abnormal gallbladder physiology (HP:0012438)2.61188102
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.58517248
47Methylmalonic acidemia (HP:0002912)2.56368600
48Hypoglycemic seizures (HP:0002173)2.56051037
49Abnormality of glycolysis (HP:0004366)2.55786239
50Abnormality of pyrimidine metabolism (HP:0004353)2.52632304
51Abnormality of the labia minora (HP:0012880)2.45680190
52Vascular calcification (HP:0004934)2.44174799
53Steatorrhea (HP:0002570)2.43960119
54Sensorimotor neuropathy (HP:0007141)2.41688563
55Metabolic acidosis (HP:0001942)2.40830480
56Spontaneous abortion (HP:0005268)2.34946890
57Myocardial infarction (HP:0001658)2.34241273
58Neonatal onset (HP:0003623)2.29846453
59Lethargy (HP:0001254)2.28798978
60Cardiovascular calcification (HP:0011915)2.26577390
61Abnormal gallbladder morphology (HP:0012437)2.24519050
62Enlarged kidneys (HP:0000105)2.23737368
63Hypochromic microcytic anemia (HP:0004840)2.23351653
64Hyperinsulinemic hypoglycemia (HP:0000825)2.23065694
65Hyperglycemia (HP:0003074)2.22759550
66Hyperuricemia (HP:0002149)2.22282555
67Increased purine levels (HP:0004368)2.22282555
68Malnutrition (HP:0004395)2.21602551
69Abnormality of vitamin metabolism (HP:0100508)2.18095778
70Cholelithiasis (HP:0001081)2.16175638
71Abnormality of vitamin B metabolism (HP:0004340)2.15647636
72Right ventricular cardiomyopathy (HP:0011663)2.14735689
73Irritability (HP:0000737)2.12502025
74Late onset (HP:0003584)2.11977574
75Acanthocytosis (HP:0001927)2.10867143
76Absent eyebrow (HP:0002223)2.09566116
77Mitral stenosis (HP:0001718)2.04447796
78Esophageal varix (HP:0002040)2.03927728
79Status epilepticus (HP:0002133)2.02973366
80Hydroxyprolinuria (HP:0003080)2.01444608
81Abnormality of proline metabolism (HP:0010907)2.01444608
82Abnormality of the Achilles tendon (HP:0005109)1.99435477
83Supernumerary spleens (HP:0009799)1.98703556
84Cerebral edema (HP:0002181)1.98394439
85Dicarboxylic aciduria (HP:0003215)1.97974732
86Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97974732
87Rickets (HP:0002748)1.97595616
88Exercise-induced muscle cramps (HP:0003710)1.95937260
89Intestinal atresia (HP:0011100)1.95545575
90Abnormal cartilage morphology (HP:0002763)1.92394062
91Papillary thyroid carcinoma (HP:0002895)1.92155570
92Back pain (HP:0003418)1.91916473
93Protuberant abdomen (HP:0001538)1.91746467
94Glomerulosclerosis (HP:0000096)1.91640072
95Hypophosphatemic rickets (HP:0004912)1.90629560
96Abnormality of the vitamin B12 metabolism (HP:0004341)1.90105184
97Medial flaring of the eyebrow (HP:0010747)1.89088575
98Turricephaly (HP:0000262)1.86677914
99Genital tract atresia (HP:0001827)1.86242116
100Labial hypoplasia (HP:0000066)1.86200506
101Focal segmental glomerulosclerosis (HP:0000097)1.86196874
102Abnormality of the gallbladder (HP:0005264)1.82690954
103Vaginal atresia (HP:0000148)1.82047745
104Chorioretinal atrophy (HP:0000533)1.81252217
105Alkalosis (HP:0001948)1.80833209
106Hepatoblastoma (HP:0002884)1.80496952
107Cortical dysplasia (HP:0002539)1.79890119
108Methylmalonic aciduria (HP:0012120)1.79792598
109Vomiting (HP:0002013)1.78867723
110Proximal tubulopathy (HP:0000114)1.78766101
111Congenital primary aphakia (HP:0007707)1.78371818
112Pancreatic islet-cell hyperplasia (HP:0004510)1.77144314
113Thyroid carcinoma (HP:0002890)1.76750801
114Hypothermia (HP:0002045)1.76458044
115Progressive inability to walk (HP:0002505)1.74230883
116Hypoplastic female external genitalia (HP:0012815)1.73381662
117Abnormality of the lower motor neuron (HP:0002366)1.72130885
118Pheochromocytoma (HP:0002666)1.71834765
119Gait imbalance (HP:0002141)1.71057441
120Abnormality of the labia (HP:0000058)1.71047536
121Vitreoretinal degeneration (HP:0000655)1.70388550
122Reduced antithrombin III activity (HP:0001976)1.70336414
123Tubulointerstitial nephritis (HP:0001970)1.67746367
124Generalized aminoaciduria (HP:0002909)1.66913379
125Glycosuria (HP:0003076)1.66853944
126Abnormality of urine glucose concentration (HP:0011016)1.66853944
127Symptomatic seizures (HP:0011145)1.66103417
128Brushfield spots (HP:0001088)1.65388167
129Tetraplegia (HP:0002445)1.64704323
130Absent eyelashes (HP:0000561)1.64579947
131Pancreatitis (HP:0001733)1.64289351
132Breast carcinoma (HP:0003002)1.62473721
133Absent hair (HP:0002298)1.62463543
134Insidious onset (HP:0003587)1.61626449
135Termporal pattern (HP:0011008)1.61626449
136Abnormality of endocrine pancreas physiology (HP:0012093)1.60862037
137Abnormality of the pancreatic islet cells (HP:0006476)1.60862037
138Confusion (HP:0001289)1.60452795
139Neoplasm of the adrenal gland (HP:0100631)1.58916294
140Megaloblastic anemia (HP:0001889)1.58912534
141Abnormal biliary tract morphology (HP:0012440)1.57661946
142Ependymoma (HP:0002888)1.57605697
143Pterygium (HP:0001059)1.57099402
144Nephrogenic diabetes insipidus (HP:0009806)1.56378699
145Scrotal hypoplasia (HP:0000046)1.55214291
146Bifid tongue (HP:0010297)1.54689070
147Delayed gross motor development (HP:0002194)1.52932610
148Tetraparesis (HP:0002273)1.51835169
149Biliary tract neoplasm (HP:0100574)1.51533812
150Bifid scrotum (HP:0000048)1.50874709
151Septo-optic dysplasia (HP:0100842)1.50853864
152Hypoplastic labia majora (HP:0000059)1.48660948
153Muscular hypotonia of the trunk (HP:0008936)1.47769371
154Median cleft lip (HP:0000161)1.47574387
155Abnormal lung lobation (HP:0002101)1.47278410
156Double outlet right ventricle (HP:0001719)1.46531645
157Congenital malformation of the right heart (HP:0011723)1.46531645
158Adrenal hypoplasia (HP:0000835)1.45612888
159Renal cortical cysts (HP:0000803)1.45265075
160Gastrointestinal atresia (HP:0002589)1.44431117
161Colon cancer (HP:0003003)1.44195073
162EEG with generalized epileptiform discharges (HP:0011198)1.43787651
163Azoospermia (HP:0000027)1.41806552
164Hypsarrhythmia (HP:0002521)1.41122493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.43448899
2TRIM284.32319252
3SIK13.21404093
4BCR2.95126177
5LATS12.56676505
6EPHA42.38333759
7ERBB42.35494757
8CASK2.33852545
9FRK2.26167385
10PKN22.15202417
11MST42.12538795
12MAP2K42.08222731
13EPHA22.06433722
14ERN12.05303308
15INSRR2.04179594
16TRIB31.88948409
17FGFR41.87889517
18EIF2AK31.85635342
19DAPK21.83994656
20MST1R1.81627211
21MAP3K21.79886892
22EIF2AK11.74863779
23MKNK21.74433278
24NEK11.74062948
25TSSK61.73662347
26TTK1.66418327
27PTK61.64369144
28LATS21.63373932
29BMPR1B1.60632152
30SRPK11.58404283
31WNK31.58352872
32PLK31.56291642
33STK38L1.55606269
34FER1.55275002
35PAK31.53749068
36PDK41.53412121
37PDK31.53412121
38DDR21.41019684
39PTK21.41004761
40PBK1.36703224
41FGFR21.35177199
42WNK41.32708717
43PRKD31.31422991
44MAP3K41.29026227
45RIPK11.28398794
46MKNK11.27836188
47MET1.26532960
48TTN1.23107812
49PLK21.21639669
50BRSK21.20727357
51KSR21.16868869
52MAP3K91.15584566
53BUB11.13664361
54ACVR1B1.10452422
55GRK11.09524938
56PDGFRA1.09440663
57MAP3K71.09408112
58PNCK1.09158453
59CSNK1G31.05237340
60MAP2K11.04708095
61RET1.03694239
62MAP3K31.01625437
63CSNK1A1L1.00459414
64PIK3CA0.99302121
65FGFR10.99256604
66PAK60.98270822
67NTRK30.98114221
68AKT30.97839809
69CAMKK10.97238632
70NTRK10.97218739
71LIMK10.96412507
72PLK40.94896922
73PHKG20.94240067
74PHKG10.94240067
75OXSR10.93592565
76PRKCE0.93439763
77WEE10.93422773
78SGK2230.92773869
79SGK4940.92773869
80MAP4K20.88561028
81MAP2K70.86443901
82SIK30.85754106
83KSR10.85670815
84CAMK1D0.85279047
85CAMK2G0.84244190
86PLK10.84105421
87PRKCZ0.83859417
88NUAK10.83846521
89STK380.83838498
90FLT30.82418949
91PDK20.80528019
92TNIK0.78824849
93ERBB20.77144038
94MINK10.75639406
95SGK30.74458859
96MAPK110.74445446
97MTOR0.74318722
98PIK3CG0.71534483
99PIM20.69070677
100SGK20.69051869
101LMTK20.68399372
102PDPK10.68160564
103MARK10.67429584
104PRKCG0.66711941
105PRKAA10.66339255
106BMX0.66334263
107MAP3K100.66052934
108PRKAA20.64655905
109FGFR30.63803185
110TAF10.63777799
111GSK3A0.62583753
112EPHB20.61919926
113ZAK0.60965117
114CAMK1G0.60514212
115CAMK2D0.59769058
116PAK40.59177746
117MAP3K120.58458432
118TAOK30.57262947
119STK240.56806775
120CAMK2B0.56618496
121ABL20.55375849
122PRKACG0.55030906
123CDK60.54331044
124EIF2AK20.53033792
125SCYL20.52977058
126CSNK1G20.52559017
127TGFBR10.51375889
128PINK10.50922212
129DYRK30.50859350
130BRD40.50474894
131PRKCH0.50078561
132CAMKK20.49658436
133PAK20.47691820
134CAMK2A0.45860165
135NEK90.45732649
136RPS6KA40.45095875
137NEK60.44539126
138ERBB30.43222110
139STK160.42845340
140CDK90.42003524
141CSNK1E0.41775914
142DYRK1B0.41770811
143RPS6KA30.41733970
144ROCK10.41051556
145DYRK20.40122044
146EPHA30.39699495
147SGK10.39043792
148YES10.37055941
149PDK10.36982794
150STK390.36932928
151MAPK130.36782431
152STK30.36679369
153CSNK1G10.34315233
154JAK20.34183067
155NLK0.33874553
156CDK80.32934607
157CSNK1A10.32904712

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.06065601
2Nitrogen metabolism_Homo sapiens_hsa009103.76347834
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.54145367
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17076151
5Arginine biosynthesis_Homo sapiens_hsa002202.97685696
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65475374
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59093108
8Protein export_Homo sapiens_hsa030602.42022983
9Tryptophan metabolism_Homo sapiens_hsa003802.41393755
10Butanoate metabolism_Homo sapiens_hsa006502.39745418
11Fatty acid degradation_Homo sapiens_hsa000712.37354604
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33937213
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29373637
14Complement and coagulation cascades_Homo sapiens_hsa046102.21296401
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00466506
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.99889303
17Propanoate metabolism_Homo sapiens_hsa006401.98060939
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.88636857
19Peroxisome_Homo sapiens_hsa041461.84623060
20Fatty acid metabolism_Homo sapiens_hsa012121.84509015
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81308283
22PPAR signaling pathway_Homo sapiens_hsa033201.75929987
23Sulfur metabolism_Homo sapiens_hsa009201.73167725
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71398041
25Bile secretion_Homo sapiens_hsa049761.70294198
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66785470
27Chemical carcinogenesis_Homo sapiens_hsa052041.66677442
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60922627
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.59343311
30Selenocompound metabolism_Homo sapiens_hsa004501.58605604
31Pyruvate metabolism_Homo sapiens_hsa006201.54599530
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45842419
33Retinol metabolism_Homo sapiens_hsa008301.45427302
34Biosynthesis of amino acids_Homo sapiens_hsa012301.42109850
35Histidine metabolism_Homo sapiens_hsa003401.41795681
36Phenylalanine metabolism_Homo sapiens_hsa003601.41377572
37beta-Alanine metabolism_Homo sapiens_hsa004101.38929151
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.37685369
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36660125
40Caffeine metabolism_Homo sapiens_hsa002321.32144539
41Starch and sucrose metabolism_Homo sapiens_hsa005001.31956677
42Carbon metabolism_Homo sapiens_hsa012001.31589384
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.29903547
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26383501
45Tyrosine metabolism_Homo sapiens_hsa003501.23301751
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.17533293
47Basal transcription factors_Homo sapiens_hsa030221.11574914
48Fatty acid elongation_Homo sapiens_hsa000621.09105305
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.07196847
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06303106
51Proteasome_Homo sapiens_hsa030501.05756137
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04797304
53Fat digestion and absorption_Homo sapiens_hsa049751.03885078
54Steroid biosynthesis_Homo sapiens_hsa001001.03201000
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99656634
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99634703
57ABC transporters_Homo sapiens_hsa020100.98258251
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97320444
59Arginine and proline metabolism_Homo sapiens_hsa003300.90526367
60Staphylococcus aureus infection_Homo sapiens_hsa051500.84960715
61Folate biosynthesis_Homo sapiens_hsa007900.84050524
62Non-homologous end-joining_Homo sapiens_hsa034500.79381610
63Vitamin digestion and absorption_Homo sapiens_hsa049770.77410209
64Lysine degradation_Homo sapiens_hsa003100.75062065
65Linoleic acid metabolism_Homo sapiens_hsa005910.72164228
66N-Glycan biosynthesis_Homo sapiens_hsa005100.69693146
67Vitamin B6 metabolism_Homo sapiens_hsa007500.68878519
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68806861
69Fatty acid biosynthesis_Homo sapiens_hsa000610.68579743
70RNA transport_Homo sapiens_hsa030130.68349895
71Vibrio cholerae infection_Homo sapiens_hsa051100.67908241
72Hippo signaling pathway_Homo sapiens_hsa043900.67691067
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65847127
74Tight junction_Homo sapiens_hsa045300.65208029
75Glycerolipid metabolism_Homo sapiens_hsa005610.60662090
76Oocyte meiosis_Homo sapiens_hsa041140.59918265
77RNA degradation_Homo sapiens_hsa030180.58833215
78Sphingolipid metabolism_Homo sapiens_hsa006000.57517891
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57100818
80Pancreatic secretion_Homo sapiens_hsa049720.55124311
81Oxidative phosphorylation_Homo sapiens_hsa001900.54240279
82Sulfur relay system_Homo sapiens_hsa041220.53011621
83Glutathione metabolism_Homo sapiens_hsa004800.52398490
84One carbon pool by folate_Homo sapiens_hsa006700.50039843
85Mismatch repair_Homo sapiens_hsa034300.49413535
86TGF-beta signaling pathway_Homo sapiens_hsa043500.48113707
87Ether lipid metabolism_Homo sapiens_hsa005650.47875301
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47036112
89Cell cycle_Homo sapiens_hsa041100.46393292
90Adherens junction_Homo sapiens_hsa045200.45592646
91Pentose phosphate pathway_Homo sapiens_hsa000300.45333715
92p53 signaling pathway_Homo sapiens_hsa041150.45043123
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44127020
94Glucagon signaling pathway_Homo sapiens_hsa049220.43455581
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43251861
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42317209
97Renin-angiotensin system_Homo sapiens_hsa046140.41764681
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39375586
99Fructose and mannose metabolism_Homo sapiens_hsa000510.38930133
100Prion diseases_Homo sapiens_hsa050200.36011882
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35887036
102Metabolic pathways_Homo sapiens_hsa011000.35584338
103Galactose metabolism_Homo sapiens_hsa000520.35258880
104Insulin resistance_Homo sapiens_hsa049310.32589471
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25296515
106GABAergic synapse_Homo sapiens_hsa047270.24877404
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.24814587
108AMPK signaling pathway_Homo sapiens_hsa041520.24192518
109Thyroid hormone synthesis_Homo sapiens_hsa049180.19270893
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.18771967
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18022196
112Insulin secretion_Homo sapiens_hsa049110.14248738
113Bladder cancer_Homo sapiens_hsa052190.12827218
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.12589150
115Insulin signaling pathway_Homo sapiens_hsa049100.11790132
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.09597214
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.09400618
118Synaptic vesicle cycle_Homo sapiens_hsa047210.08882167
119Protein digestion and absorption_Homo sapiens_hsa049740.06678640
120Mineral absorption_Homo sapiens_hsa049780.06646068
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05543650
122Circadian rhythm_Homo sapiens_hsa047100.03778906
123Type II diabetes mellitus_Homo sapiens_hsa049300.01858928
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.01854036
125Ovarian steroidogenesis_Homo sapiens_hsa049130.01147303
126Nicotine addiction_Homo sapiens_hsa050330.00983441
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.00830151
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.00458827
129ECM-receptor interaction_Homo sapiens_hsa04512-0.0255258
130Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0131128
131Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0046877

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