CLDN11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.94252844
2myelination (GO:0042552)7.44277637
3* axon ensheathment (GO:0008366)7.15389240
4* ensheathment of neurons (GO:0007272)7.15389240
5long-chain fatty acid biosynthetic process (GO:0042759)6.06983722
6myelin maintenance (GO:0043217)5.81034698
7negative regulation of neurotransmitter secretion (GO:0046929)5.38134399
8oligodendrocyte differentiation (GO:0048709)4.99811175
9cholesterol biosynthetic process (GO:0006695)4.99380627
10negative regulation of neurotransmitter transport (GO:0051589)4.92281367
11creatine metabolic process (GO:0006600)4.75529959
12sequestering of extracellular ligand from receptor (GO:0035581)4.69496441
13protein heterotrimerization (GO:0070208)4.60373807
14regulation of collateral sprouting (GO:0048670)4.53078237
15apical protein localization (GO:0045176)4.47890607
16establishment of mitochondrion localization (GO:0051654)4.43257485
17asymmetric protein localization (GO:0008105)4.41030423
18astrocyte development (GO:0014002)4.38400275
19negative regulation of synaptic transmission, GABAergic (GO:0032229)4.37144918
20glycerophospholipid catabolic process (GO:0046475)4.36269346
21sterol biosynthetic process (GO:0016126)4.35841676
22negative regulation of protein localization to cell surface (GO:2000009)4.34266157
23peptidyl-tyrosine autophosphorylation (GO:0038083)4.24081337
24positive regulation of oligodendrocyte differentiation (GO:0048714)4.18833069
25presynaptic membrane organization (GO:0097090)4.17421820
26response to methylmercury (GO:0051597)4.16246100
27synaptic vesicle docking involved in exocytosis (GO:0016081)4.14435886
28substantia nigra development (GO:0021762)4.11105139
29photoreceptor cell differentiation (GO:0046530)4.10226407
30eye photoreceptor cell differentiation (GO:0001754)4.10226407
31L-amino acid import (GO:0043092)4.05135249
32long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.02248727
33isoprenoid biosynthetic process (GO:0008299)4.00892152
34blood vessel maturation (GO:0001955)3.89438376
35extracellular matrix assembly (GO:0085029)3.88155695
36glutamate secretion (GO:0014047)3.87847665
37presynaptic membrane assembly (GO:0097105)3.85773154
38amyloid precursor protein metabolic process (GO:0042982)3.83352605
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82355228
40dermatan sulfate biosynthetic process (GO:0030208)3.81363603
41import into cell (GO:0098657)3.81287338
42negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.73521496
43response to redox state (GO:0051775)3.72185032
44lymphangiogenesis (GO:0001946)3.71124076
45long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.69878799
46myelination in peripheral nervous system (GO:0022011)3.69765967
47peripheral nervous system axon ensheathment (GO:0032292)3.69765967
48response to lipoprotein particle (GO:0055094)3.67253026
49virion attachment to host cell (GO:0019062)3.62251302
50adhesion of symbiont to host cell (GO:0044650)3.62251302
51cell migration involved in heart development (GO:0060973)3.61722418
52cellular potassium ion homeostasis (GO:0030007)3.52431333
53dermatan sulfate metabolic process (GO:0030205)3.50869351
54regulation of short-term neuronal synaptic plasticity (GO:0048172)3.48601822
55fatty-acyl-CoA biosynthetic process (GO:0046949)3.47313545
56protein palmitoylation (GO:0018345)3.46706250
57positive regulation of fibroblast migration (GO:0010763)3.35733707
58neuron remodeling (GO:0016322)3.34241046
59collagen fibril organization (GO:0030199)3.30117041
60negative regulation of axonogenesis (GO:0050771)3.29304853
61postsynaptic membrane organization (GO:0001941)3.27116933
62fatty-acyl-CoA metabolic process (GO:0035337)3.23991619
63adult walking behavior (GO:0007628)3.23905716
64magnesium ion transport (GO:0015693)3.23808237
65mesenchymal-epithelial cell signaling (GO:0060638)3.23561298
66kidney mesenchyme development (GO:0072074)3.20635045
67membrane tubulation (GO:0097320)3.19968691
68limb bud formation (GO:0060174)3.16934525
69axon development (GO:0061564)3.16725311
70locomotory exploration behavior (GO:0035641)3.13141605
71regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.09311047
72regulation of lipoprotein metabolic process (GO:0050746)3.09101673
73negative regulation of leukocyte chemotaxis (GO:0002689)3.06597594
74transmission of nerve impulse (GO:0019226)3.06229559
75very long-chain fatty acid metabolic process (GO:0000038)3.05577048
76GPI anchor biosynthetic process (GO:0006506)3.05546091
77positive regulation of action potential (GO:0045760)3.05331133
78synaptic vesicle maturation (GO:0016188)3.01959371
79negative regulation of execution phase of apoptosis (GO:1900118)3.00938101
80GPI anchor metabolic process (GO:0006505)2.99929254
81neuron cell-cell adhesion (GO:0007158)2.98351211
82glycosylceramide metabolic process (GO:0006677)2.97109553
83cerebral cortex radially oriented cell migration (GO:0021799)2.96636139
84cellular response to epinephrine stimulus (GO:0071872)2.96310925
85negative regulation of BMP signaling pathway (GO:0030514)2.95976910
86amino acid import (GO:0043090)2.94907951
87gamma-aminobutyric acid transport (GO:0015812)2.91782078
88chondrocyte proliferation (GO:0035988)2.91766960
89bone trabecula formation (GO:0060346)2.91703424
90peptidyl-cysteine modification (GO:0018198)2.91521106
91endocardial cushion development (GO:0003197)2.90724567
92cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.90024580
93peripheral nervous system development (GO:0007422)2.89730128
94negative regulation of axon extension (GO:0030517)2.89088447
95amyloid precursor protein catabolic process (GO:0042987)2.88896078
96endodermal cell differentiation (GO:0035987)2.87956081
97glycosphingolipid biosynthetic process (GO:0006688)2.85588141
98extracellular regulation of signal transduction (GO:1900115)2.85548623
99extracellular negative regulation of signal transduction (GO:1900116)2.85548623
100negative regulation of JUN kinase activity (GO:0043508)2.84903250
101leukocyte migration involved in inflammatory response (GO:0002523)2.84500159
102negative regulation of axon extension involved in axon guidance (GO:0048843)2.84273941
103positive regulation of glial cell differentiation (GO:0045687)2.84168658
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.83160074
105glial cell development (GO:0021782)2.83068014
106metanephric mesenchyme development (GO:0072075)2.82427857
107positive regulation of synapse assembly (GO:0051965)2.81731327
108nucleotide transmembrane transport (GO:1901679)2.80379656
109neural nucleus development (GO:0048857)2.79247699
110enteric nervous system development (GO:0048484)2.78890453
111positive regulation of cellular amine metabolic process (GO:0033240)2.78718378
112acyl-CoA biosynthetic process (GO:0071616)2.77741311
113thioester biosynthetic process (GO:0035384)2.77741311
114synaptic vesicle exocytosis (GO:0016079)2.75160889
115cellular response to vitamin (GO:0071295)2.74720906
116iron coordination entity transport (GO:1901678)2.74206202
117neuronal ion channel clustering (GO:0045161)2.73798165
118preassembly of GPI anchor in ER membrane (GO:0016254)2.73224907
119response to gravity (GO:0009629)2.72898747
120positive regulation of gliogenesis (GO:0014015)2.69381638
121negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.69034186
122organ growth (GO:0035265)2.68757569
123pericardium development (GO:0060039)2.68713838
124heme transport (GO:0015886)2.68704676
125regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.68278369
126positive regulation of actin filament depolymerization (GO:0030836)2.66790289
127negative regulation of nitric-oxide synthase activity (GO:0051001)2.65922991
128glial cell differentiation (GO:0010001)2.63703299
129axon extension involved in axon guidance (GO:0048846)2.62464964
130neuron projection extension involved in neuron projection guidance (GO:1902284)2.62464964
131adhesion of symbiont to host (GO:0044406)2.62132734
132middle ear morphogenesis (GO:0042474)2.61894196
133positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.61533223
134response to epinephrine (GO:0071871)2.60822004
135Leydig cell differentiation (GO:0033327)2.60262567
136vocalization behavior (GO:0071625)2.60165943
137nerve growth factor signaling pathway (GO:0038180)2.59953563
138response to lead ion (GO:0010288)2.59668722
139regulation of plasminogen activation (GO:0010755)2.58525488
140neurotransmitter uptake (GO:0001504)2.57894412
141cellular response to catecholamine stimulus (GO:0071870)2.56617045
142cellular response to monoamine stimulus (GO:0071868)2.56617045
143tooth mineralization (GO:0034505)2.55040231
144microtubule polymerization or depolymerization (GO:0031109)2.55024311
145positive regulation of meiosis (GO:0045836)2.54929881
146peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.53751215
147heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.52238393
148interleukin-6-mediated signaling pathway (GO:0070102)2.52220021
149protein localization to endosome (GO:0036010)2.51970001
150detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.51514863
151detection of temperature stimulus involved in sensory perception (GO:0050961)2.51514863
152regulation of axon extension involved in axon guidance (GO:0048841)2.51433190
153type B pancreatic cell proliferation (GO:0044342)2.51064269
154axonal fasciculation (GO:0007413)2.48956899
155positive regulation of cardiac muscle cell differentiation (GO:2000727)2.48762185
156neuronal action potential propagation (GO:0019227)2.48429965
157negative regulation of axon guidance (GO:1902668)2.48137769
158endothelial cell proliferation (GO:0001935)2.46728905
159positive regulation of protein autophosphorylation (GO:0031954)2.45913525
160artery development (GO:0060840)2.45138564
161regulation of mesoderm development (GO:2000380)2.40377224
162smooth muscle tissue development (GO:0048745)2.40184985
163regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.40103486
164synaptic transmission, glutamatergic (GO:0035249)2.38194418
165positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.37840019
166regulation of neurotransmitter uptake (GO:0051580)2.37052430
167regulation of neuronal synaptic plasticity (GO:0048168)2.35605864
168anatomical structure maturation (GO:0071695)2.34711206
169inner ear receptor cell development (GO:0060119)2.33624352
170neuron recognition (GO:0008038)2.33452486
171positive regulation of dendritic spine development (GO:0060999)2.32909083
172positive regulation of synapse maturation (GO:0090129)2.32864379
173ionotropic glutamate receptor signaling pathway (GO:0035235)2.32670628
174venous blood vessel morphogenesis (GO:0048845)2.32339455
175regulation of axon guidance (GO:1902667)2.31914579
176positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.31834093
177exploration behavior (GO:0035640)2.31514980
178glutamate receptor signaling pathway (GO:0007215)2.31092129
179positive regulation of meiotic cell cycle (GO:0051446)2.30851102
180astrocyte differentiation (GO:0048708)2.30828544
181regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.29051362
182potassium ion homeostasis (GO:0055075)2.27935812
183outer ear morphogenesis (GO:0042473)2.27286107
184axon ensheathment in central nervous system (GO:0032291)12.1281233
185central nervous system myelination (GO:0022010)12.1281233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.15373668
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.93597431
3* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.74599654
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39824684
5TAF15_26573619_Chip-Seq_HEK293_Human2.37435889
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36214616
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27611239
8EZH2_22144423_ChIP-Seq_EOC_Human2.14521644
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.06480470
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06022979
11* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.05205908
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04342274
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02181730
14* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96135892
15* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96135892
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92630751
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88406255
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.87674356
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87238387
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85271180
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84937575
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.84393167
23AR_21572438_ChIP-Seq_LNCaP_Human1.83417010
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82521536
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81806551
26ER_23166858_ChIP-Seq_MCF-7_Human1.74684902
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.71998127
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71614917
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70456587
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66581395
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63788097
32VDR_22108803_ChIP-Seq_LS180_Human1.62537487
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.62196160
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56428398
35DROSHA_22980978_ChIP-Seq_HELA_Human1.56354181
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55961158
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.53549324
38TP53_16413492_ChIP-PET_HCT116_Human1.52557743
39TP53_18474530_ChIP-ChIP_U2OS_Human1.52072016
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.51506747
41CJUN_26792858_Chip-Seq_BT549_Human1.51073422
42STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.51012753
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.50280968
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48900122
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48170070
46BRD4_25478319_ChIP-Seq_HGPS_Human1.47550941
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47122436
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44277026
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.41803290
50TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40858089
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32743201
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32625426
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32035984
54FUS_26573619_Chip-Seq_HEK293_Human1.29188704
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26581381
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.26156020
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25557741
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25024504
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24482770
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21944179
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21753964
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20082115
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.19906302
64* P300_19829295_ChIP-Seq_ESCs_Human1.17045522
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16821530
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16821530
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15037774
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14194245
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13557166
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12810918
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.12605813
72LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12475753
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12115219
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.11972951
75SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.11926674
76STAT3_23295773_ChIP-Seq_U87_Human1.10246181
77EOMES_21245162_ChIP-Seq_HESCs_Human1.09908260
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09298531
79HTT_18923047_ChIP-ChIP_STHdh_Human1.08543320
80KDM2B_26808549_Chip-Seq_REH_Human1.07837391
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.07461787
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06817991
83CMYC_18555785_Chip-Seq_ESCs_Mouse1.06657681
84GATA1_26923725_Chip-Seq_HPCs_Mouse1.06391980
85REST_21632747_ChIP-Seq_MESCs_Mouse1.06070334
86RNF2_27304074_Chip-Seq_NSC_Mouse1.05400761
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.04836337
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04140448
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.04037261
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.03673211
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03572159
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03233643
93JUN_21703547_ChIP-Seq_K562_Human1.03144811
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.02971138
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.01100306
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00976862
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00452518
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00049818
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97091393
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96084007
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95971100
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95309328
103TP53_23651856_ChIP-Seq_MEFs_Mouse0.95090631
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95082918
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94540074
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93893488
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.93826245
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93543855
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.93510415
110SMAD3_21741376_ChIP-Seq_HESCs_Human0.93381718
111* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93018271
112* P300_18555785_Chip-Seq_ESCs_Mouse0.92912096
113TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92623735
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92376254
115SMAD3_21741376_ChIP-Seq_ESCs_Human0.92214385
116BCAT_22108803_ChIP-Seq_LS180_Human0.91839554
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.91751753
118* TCF4_23295773_ChIP-Seq_U87_Human0.91712970
119TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91692593
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89886066
121SMAD4_21799915_ChIP-Seq_A2780_Human0.89569614
122REST_18959480_ChIP-ChIP_MESCs_Mouse0.89107674
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88911872
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.88305621
125SOX2_19829295_ChIP-Seq_ESCs_Human0.88187710
126NANOG_19829295_ChIP-Seq_ESCs_Human0.88187710
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88025962
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87863428
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87590167
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87218746
131* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87041616
132POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86749326
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.86604043
134TBL1_22424771_ChIP-Seq_293T_Human0.86282651
135AHR_22903824_ChIP-Seq_MCF-7_Human0.86185691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.89662763
2MP0003880_abnormal_central_pattern3.93811941
3MP0005503_abnormal_tendon_morphology3.81377890
4MP0003950_abnormal_plasma_membrane3.50778246
5MP0003690_abnormal_glial_cell3.36074223
6MP0004270_analgesia3.33802101
7MP0003279_aneurysm3.33538801
8MP0001958_emphysema3.01985103
9MP0004742_abnormal_vestibular_system2.85062129
10MP0001529_abnormal_vocalization2.84842827
11MP0005171_absent_coat_pigmentation2.83948809
12MP0003329_amyloid_beta_deposits2.79492868
13MP0003136_yellow_coat_color2.69138127
14MP0005275_abnormal_skin_tensile2.63524647
15MP0002272_abnormal_nervous_system2.57448019
16MP0010368_abnormal_lymphatic_system2.56738993
17MP0004272_abnormal_basement_membrane2.53845863
18MP0001486_abnormal_startle_reflex2.52566720
19MP0003634_abnormal_glial_cell2.51485196
20MP0009780_abnormal_chondrocyte_physiolo2.50942338
21MP0001905_abnormal_dopamine_level2.44431708
22MP0001542_abnormal_bone_strength2.37347352
23MP0001485_abnormal_pinna_reflex2.37005688
24MP0004142_abnormal_muscle_tone2.33390148
25MP0005409_darkened_coat_color2.25269373
26MP0000778_abnormal_nervous_system2.23353684
27MP0009384_cardiac_valve_regurgitation2.22128955
28MP0002064_seizures2.18060800
29MP0003705_abnormal_hypodermis_morpholog2.06228505
30MP0006054_spinal_hemorrhage1.99636300
31MP0005451_abnormal_body_composition1.95640505
32MP0005257_abnormal_intraocular_pressure1.94358171
33MP0005410_abnormal_fertilization1.94089292
34MP0004859_abnormal_synaptic_plasticity1.91595186
35MP0003632_abnormal_nervous_system1.88104795
36MP0004381_abnormal_hair_follicle1.86654959
37* MP0002229_neurodegeneration1.83587221
38MP0005423_abnormal_somatic_nervous1.83579693
39MP0000462_abnormal_digestive_system1.82159712
40MP0010678_abnormal_skin_adnexa1.80742346
41MP0009046_muscle_twitch1.74756493
42MP0005508_abnormal_skeleton_morphology1.72504891
43MP0000383_abnormal_hair_follicle1.68896707
44MP0002734_abnormal_mechanical_nocicepti1.66090952
45MP0009745_abnormal_behavioral_response1.65347503
46MP0000049_abnormal_middle_ear1.65205995
47MP0010386_abnormal_urinary_bladder1.62068118
48MP0003635_abnormal_synaptic_transmissio1.61009215
49MP0002736_abnormal_nociception_after1.56208401
50MP0008260_abnormal_autophagy1.52377883
51MP0005595_abnormal_vascular_smooth1.51566173
52MP0000955_abnormal_spinal_cord1.48900100
53MP0004134_abnormal_chest_morphology1.47141416
54MP0004043_abnormal_pH_regulation1.45929542
55MP0000604_amyloidosis1.42584439
56MP0001440_abnormal_grooming_behavior1.40711770
57MP0004147_increased_porphyrin_level1.40281812
58MP0003631_nervous_system_phenotype1.39819445
59MP0000767_abnormal_smooth_muscle1.38991595
60* MP0002882_abnormal_neuron_morphology1.36685308
61MP0003283_abnormal_digestive_organ1.35997367
62MP0000534_abnormal_ureter_morphology1.35703984
63MP0000747_muscle_weakness1.31362529
64MP0008569_lethality_at_weaning1.26572250
65MP0002572_abnormal_emotion/affect_behav1.26436802
66MP0001879_abnormal_lymphatic_vessel1.22979897
67* MP0002066_abnormal_motor_capabilities/c1.22400437
68MP0003195_calcinosis1.21010319
69MP0001346_abnormal_lacrimal_gland1.19801152
70* MP0005551_abnormal_eye_electrophysiolog1.18004554
71MP0003633_abnormal_nervous_system1.17808294
72MP0005623_abnormal_meninges_morphology1.17724137
73MP0001970_abnormal_pain_threshold1.17431454
74MP0001299_abnormal_eye_distance/1.17141140
75MP0000013_abnormal_adipose_tissue1.17053988
76MP0002108_abnormal_muscle_morphology1.17009487
77MP0010030_abnormal_orbit_morphology1.15951527
78MP0003806_abnormal_nucleotide_metabolis1.15481768
79MP0001661_extended_life_span1.15174134
80MP0003879_abnormal_hair_cell1.15077344
81* MP0002752_abnormal_somatic_nervous1.15072848
82MP0004924_abnormal_behavior1.14212700
83MP0005386_behavior/neurological_phenoty1.14212700
84MP0002063_abnormal_learning/memory/cond1.13829973
85* MP0001963_abnormal_hearing_physiology1.12307518
86MP0002067_abnormal_sensory_capabilities1.11947966
87MP0000428_abnormal_craniofacial_morphol1.07833946
88MP0001851_eye_inflammation1.06477247
89MP0003942_abnormal_urinary_system1.05169722
90* MP0004885_abnormal_endolymph1.03711853
91MP0005195_abnormal_posterior_eye1.02341545
92MP0000647_abnormal_sebaceous_gland1.02010765
93MP0005408_hypopigmentation1.01015444
94MP0003385_abnormal_body_wall0.99779656
95MP0000566_synostosis0.99368741
96MP0002733_abnormal_thermal_nociception0.98927275
97MP0002896_abnormal_bone_mineralization0.97585059
98MP0000163_abnormal_cartilage_morphology0.96729501
99MP0003938_abnormal_ear_development0.95401033
100MP0000762_abnormal_tongue_morphology0.95325380
101MP0005646_abnormal_pituitary_gland0.92601639
102MP0001348_abnormal_lacrimal_gland0.92470341
103MP0000569_abnormal_digit_pigmentation0.92243288
104MP0003937_abnormal_limbs/digits/tail_de0.91420556
105MP0004145_abnormal_muscle_electrophysio0.89891003
106MP0005023_abnormal_wound_healing0.89324259
107MP0006276_abnormal_autonomic_nervous0.88451493
108MP0002115_abnormal_skeleton_extremities0.85530017
109MP0001177_atelectasis0.85253290
110MP0002160_abnormal_reproductive_system0.84870275
111MP0005058_abnormal_lysosome_morphology0.82744911
112MP0002152_abnormal_brain_morphology0.82222870
113MP0000467_abnormal_esophagus_morphology0.81904171
114MP0005390_skeleton_phenotype0.79615833
115MP0006072_abnormal_retinal_apoptosis0.78072354
116MP0002932_abnormal_joint_morphology0.76958526
117MP0002295_abnormal_pulmonary_circulatio0.76093667
118MP0008438_abnormal_cutaneous_collagen0.75826244
119MP0005253_abnormal_eye_physiology0.75204838
120MP0000579_abnormal_nail_morphology0.74482614
121MP0001984_abnormal_olfaction0.69964876
122MP0005167_abnormal_blood-brain_barrier0.69676159
123MP0003941_abnormal_skin_development0.69307550
124MP0002735_abnormal_chemical_nociception0.69173157
125MP0002282_abnormal_trachea_morphology0.68802455
126MP0001501_abnormal_sleep_pattern0.68740161
127MP0001243_abnormal_dermal_layer0.67973511
128MP0006082_CNS_inflammation0.67107605
129MP0002933_joint_inflammation0.66925381
130MP0001727_abnormal_embryo_implantation0.66681560
131MP0003091_abnormal_cell_migration0.66602160
132MP0002184_abnormal_innervation0.66358260
133MP0005388_respiratory_system_phenotype0.66092887
134MP0002116_abnormal_craniofacial_bone0.65669036
135* MP0000026_abnormal_inner_ear0.65413067
136MP0000230_abnormal_systemic_arterial0.64869594
137MP0000751_myopathy0.64657940
138MP0002090_abnormal_vision0.63784325
139MP0001968_abnormal_touch/_nociception0.63638022
140MP0001502_abnormal_circadian_rhythm0.61363842
141MP0004133_heterotaxia0.60680167
142MP0001340_abnormal_eyelid_morphology0.59950155
143MP0004185_abnormal_adipocyte_glucose0.58861945
144MP0003137_abnormal_impulse_conducting0.58353970
145MP0004036_abnormal_muscle_relaxation0.58044748
146MP0002557_abnormal_social/conspecific_i0.57972156
147MP0009250_abnormal_appendicular_skeleto0.57092932
148MP0000639_abnormal_adrenal_gland0.56024182
149MP0002133_abnormal_respiratory_system0.55149880

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.91242267
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.91242267
3Protrusio acetabuli (HP:0003179)6.43508335
4Neurofibrillary tangles (HP:0002185)6.25641334
5Premature rupture of membranes (HP:0001788)6.09044067
6Abnormality of the corticospinal tract (HP:0002492)5.08485575
7Parakeratosis (HP:0001036)4.99199532
8Peripheral hypomyelination (HP:0007182)4.96977750
9Sensory axonal neuropathy (HP:0003390)4.85780297
10Follicular hyperkeratosis (HP:0007502)4.83852724
11Ankle contracture (HP:0006466)4.75529153
12Cerebral inclusion bodies (HP:0100314)4.46787298
13Vascular tortuosity (HP:0004948)4.39978970
14Aortic aneurysm (HP:0004942)4.39559725
15Cerebral hypomyelination (HP:0006808)4.38377914
16Slender build (HP:0001533)4.13325379
17Onion bulb formation (HP:0003383)4.07481314
18Aortic dissection (HP:0002647)4.04842370
19Broad metatarsal (HP:0001783)3.89129358
20Type 1 muscle fiber predominance (HP:0003803)3.85166019
21Soft skin (HP:0000977)3.83885595
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.80270782
23Abnormal auditory evoked potentials (HP:0006958)3.69239545
24Spastic gait (HP:0002064)3.65874548
25Supranuclear gaze palsy (HP:0000605)3.57134005
26Arterial tortuosity (HP:0005116)3.56369162
27Spinal rigidity (HP:0003306)3.50002726
28Alacrima (HP:0000522)3.46906312
29Shallow orbits (HP:0000586)3.45973525
30Bladder diverticulum (HP:0000015)3.45772034
31Intention tremor (HP:0002080)3.21320062
32Dysmetria (HP:0001310)3.18994708
33Ankle clonus (HP:0011448)3.17993005
34Leukodystrophy (HP:0002415)3.16181887
35Insidious onset (HP:0003587)3.15308965
36Termporal pattern (HP:0011008)3.15308965
37Abnormality of dentin (HP:0010299)3.15116261
38Hypoventilation (HP:0002791)3.14580004
39Keratoconus (HP:0000563)3.13752299
40Increased corneal curvature (HP:0100692)3.13752299
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.12661192
42Focal seizures (HP:0007359)3.10970382
43Focal motor seizures (HP:0011153)2.97715548
44Abnormality of glycolysis (HP:0004366)2.95873980
45Increased serum pyruvate (HP:0003542)2.95873980
46Overgrowth (HP:0001548)2.93139454
47Wormian bones (HP:0002645)2.91625498
48Slow saccadic eye movements (HP:0000514)2.87843811
49Retinal dysplasia (HP:0007973)2.85530699
50Akinesia (HP:0002304)2.82337365
51Scanning speech (HP:0002168)2.81545040
52Hypoplastic pelvis (HP:0008839)2.81163638
53Neonatal short-limb short stature (HP:0008921)2.80246401
54Spastic paraparesis (HP:0002313)2.79906849
55Mesomelia (HP:0003027)2.78437303
56Torticollis (HP:0000473)2.78009696
57Decreased lacrimation (HP:0000633)2.75586073
58Myokymia (HP:0002411)2.73885997
59CNS hypomyelination (HP:0003429)2.71557833
60Bowel diverticulosis (HP:0005222)2.71124801
61Congenital ichthyosiform erythroderma (HP:0007431)2.69590044
62Segmental peripheral demyelination/remyelination (HP:0003481)2.69393274
63Stridor (HP:0010307)2.68604091
64Wrist flexion contracture (HP:0001239)2.66406983
65Action tremor (HP:0002345)2.64867001
66Thickened helices (HP:0000391)2.63870003
67Anteriorly placed anus (HP:0001545)2.62668916
68Genu recurvatum (HP:0002816)2.59178643
69Premature skin wrinkling (HP:0100678)2.57714668
70Absent septum pellucidum (HP:0001331)2.55638313
71Clumsiness (HP:0002312)2.54443734
72Morphological abnormality of the inner ear (HP:0011390)2.51511252
73Autoamputation (HP:0001218)2.51115784
74White forelock (HP:0002211)2.42949307
75Atrophic scars (HP:0001075)2.41354320
76Cerebral hemorrhage (HP:0001342)2.39973400
77Patchy hypopigmentation of hair (HP:0011365)2.39960642
78Spondylolisthesis (HP:0003302)2.38885571
79Spastic tetraparesis (HP:0001285)2.38017673
80Increased circulating renin level (HP:0000848)2.37500009
81Cervical subluxation (HP:0003308)2.37442008
82Split foot (HP:0001839)2.37437135
83Fragile skin (HP:0001030)2.34241566
84Coronal craniosynostosis (HP:0004440)2.31594057
85Mild short stature (HP:0003502)2.30808468
86Aortic valve stenosis (HP:0001650)2.30456218
87Aortic regurgitation (HP:0001659)2.28293795
88Atonic seizures (HP:0010819)2.27023564
89Bell-shaped thorax (HP:0001591)2.26167653
90Hypoplasia of the iris (HP:0007676)2.24220837
91Mildly elevated creatine phosphokinase (HP:0008180)2.22733007
92Pheochromocytoma (HP:0002666)2.22615221
93Peritonitis (HP:0002586)2.21222732
94Abnormality of binocular vision (HP:0011514)2.20288954
95Diplopia (HP:0000651)2.20288954
96Foot dorsiflexor weakness (HP:0009027)2.18626014
97Hyperextensible skin (HP:0000974)2.18357265
98Dilatation of the ascending aorta (HP:0005111)2.16943723
99Abnormality of the septum pellucidum (HP:0007375)2.16884658
100Muscle fiber splitting (HP:0003555)2.16712651
101Joint laxity (HP:0001388)2.15516079
102Abnormality of the phalanges of the 2nd finger (HP:0009541)2.14362241
103Hepatosplenomegaly (HP:0001433)2.11813457
104Blue sclerae (HP:0000592)2.11278824
105Partial agenesis of the corpus callosum (HP:0001338)2.09895093
106Metabolic alkalosis (HP:0200114)2.09112352
107Lower limb muscle weakness (HP:0007340)2.08787758
108Short hallux (HP:0010109)2.07510197
109Poor speech (HP:0002465)2.07363270
110Narrow nasal bridge (HP:0000446)2.05983035
111Bulbous nose (HP:0000414)2.05678081
112Cupped ear (HP:0000378)2.05463965
113Infantile muscular hypotonia (HP:0008947)2.04532136
114Craniofacial dystonia (HP:0012179)2.04006492
115Hypomagnesemia (HP:0002917)2.03865739
116Clonus (HP:0002169)2.03398268
117Increased variability in muscle fiber diameter (HP:0003557)2.01145999
118Axonal loss (HP:0003447)2.01046733
119Morphological abnormality of the middle ear (HP:0008609)2.00821181
120Focal dystonia (HP:0004373)2.00576694
121Paraparesis (HP:0002385)2.00179367
122Methylmalonic acidemia (HP:0002912)1.99041272
123Abnormality of the foot musculature (HP:0001436)1.98803948
124Aplasia involving bones of the upper limbs (HP:0009823)1.98274468
125Aplasia of the phalanges of the hand (HP:0009802)1.98274468
126Aplasia involving bones of the extremities (HP:0009825)1.98274468
127Wide anterior fontanel (HP:0000260)1.97734123
128Decreased motor nerve conduction velocity (HP:0003431)1.97293481
129Mitral valve prolapse (HP:0001634)1.97129293
130Humeroradial synostosis (HP:0003041)1.97050557
131Synostosis involving the elbow (HP:0003938)1.97050557
132Biconcave vertebral bodies (HP:0004586)1.96818957
133Limited hip movement (HP:0008800)1.95171876
134Hypokalemic alkalosis (HP:0001949)1.94873296
135Partial duplication of thumb phalanx (HP:0009944)1.94513601
136Bowel incontinence (HP:0002607)1.92744421
137Aplasia/Hypoplasia of the hallux (HP:0008362)1.92493236
138Urinary incontinence (HP:0000020)1.91304654
139Febrile seizures (HP:0002373)1.91247499
140Neuroendocrine neoplasm (HP:0100634)1.90924147
141Esophageal atresia (HP:0002032)1.90637212
142Gowers sign (HP:0003391)1.89644826
143Cardiovascular calcification (HP:0011915)1.89208167
144Megalencephaly (HP:0001355)1.86353622
145Urinary urgency (HP:0000012)1.86339235
146Morphological abnormality of the pyramidal tract (HP:0002062)1.85754109
147Hyporeflexia of lower limbs (HP:0002600)1.83977399
148Peripheral demyelination (HP:0011096)1.82908418
149Mitral regurgitation (HP:0001653)1.80400513
150Buphthalmos (HP:0000557)1.79501484
151Abnormal large intestine physiology (HP:0012700)1.79500936
152Vertebral compression fractures (HP:0002953)1.79312096
153Obstructive sleep apnea (HP:0002870)1.79146369
154Septo-optic dysplasia (HP:0100842)1.76927579
155Hammertoe (HP:0001765)1.76724840
156Abnormality of the middle phalanges of the toes (HP:0010183)1.75876711
157Erythroderma (HP:0001019)1.75764648
158Distal sensory impairment (HP:0002936)1.75665470
159Renal Fanconi syndrome (HP:0001994)1.75555179
160Joint stiffness (HP:0001387)1.75379729
161Adrenal hypoplasia (HP:0000835)1.74518366
162Bradycardia (HP:0001662)1.73492013
163Epileptic encephalopathy (HP:0200134)1.72140246
164Anomalous pulmonary venous return (HP:0010772)1.72062540
165Synostosis of carpal bones (HP:0005048)1.71550594
166Striae distensae (HP:0001065)1.71018524
167Elbow flexion contracture (HP:0002987)1.70687610
168Partial duplication of the phalanx of hand (HP:0009999)1.70538074
169Abnormality of the salivary glands (HP:0010286)1.70265152
170Protruding ear (HP:0000411)1.70049044
171Progressive cerebellar ataxia (HP:0002073)1.69456077
172Generalized amyotrophy (HP:0003700)1.68537257
173Hydroxyprolinuria (HP:0003080)1.68362020
174Abnormality of proline metabolism (HP:0010907)1.68362020
175Choreoathetosis (HP:0001266)1.67910110
176Broad ribs (HP:0000885)1.66253283
177Delayed closure of the anterior fontanelle (HP:0001476)1.66197529
178Limb-girdle muscle weakness (HP:0003325)1.65937020
179Diminished movement (HP:0002374)1.64190192
180Hip contracture (HP:0003273)1.63711922
181Myelomeningocele (HP:0002475)1.63671571
182Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.63317028
183Abnormality of the anterior chamber (HP:0000593)1.63149414
184Delayed gross motor development (HP:0002194)1.61850770
185Ectopia lentis (HP:0001083)1.60253808
186Hallux valgus (HP:0001822)1.59967991
187Deviation of the hallux (HP:0010051)1.59252306
188Abnormal eating behavior (HP:0100738)1.58708767
189Tarsal synostosis (HP:0008368)1.57515261
190Congenital glaucoma (HP:0001087)1.55609660

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.60434459
2OXSR14.63985491
3TIE13.42063228
4EPHB13.33466925
5PKN12.86673820
6BCR2.78332443
7WNK42.61319211
8MYLK2.56008740
9CDK192.44367468
10PBK2.35050949
11MET2.29026061
12LIMK12.27143150
13NTRK32.25874103
14MAPKAPK52.24761976
15PLK22.23778226
16TNIK2.17542488
17FGFR22.04314983
18WNK12.03893624
19TGFBR22.02560919
20PDGFRA1.98031570
21GRK51.97078764
22PINK11.93568247
23CSNK1G31.89486125
24UHMK11.85560673
25TESK21.84789395
26PTK21.84699335
27CSNK1A1L1.82835953
28PNCK1.78011534
29NEK61.70661369
30EPHB21.70357741
31ADRBK11.69835201
32NTRK11.58809790
33LATS21.58285936
34ROCK21.57611262
35CAMK2B1.56658091
36PRPF4B1.56657589
37ICK1.52526432
38DAPK21.49969727
39CSNK1G11.48831562
40CLK11.48358091
41PRKD31.46775478
42CSNK1G21.39509723
43FGR1.37081511
44PTK2B1.36971546
45PRKCG1.30874863
46CAMK2D1.29645820
47CASK1.28698041
48PAK61.21200647
49NEK91.19258556
50MOS1.17061721
51FRK1.16517440
52SGK2231.15059849
53SGK4941.15059849
54TYRO31.14067130
55EPHA41.13796668
56PRKD21.11204490
57STK381.10949977
58MST41.07624319
59CAMK11.00919928
60CAMK2G1.00598570
61PRKG21.00507429
62MAPK151.00413258
63DYRK20.99583156
64MARK10.96115904
65TGFBR10.95768809
66ABL20.89530301
67MUSK0.88360212
68CDK140.87322964
69PAK30.86338945
70KIT0.84244409
71MARK20.82628245
72CAMKK20.82190955
73MINK10.81781472
74MAP2K10.81129873
75PRKCQ0.80717803
76CAMK2A0.80460974
77CDK50.77458115
78CDK150.75618985
79CAMKK10.75044689
80ERBB40.73918741
81PRKD10.73531347
82RIPK10.72123890
83CDK180.70191233
84MAP3K90.70055822
85FLT30.69864505
86IRAK20.68404267
87CDK11A0.68324918
88PHKG20.67564844
89PHKG10.67564844
90ARAF0.65166766
91TRPM70.62830936
92BMPR1B0.62502122
93PRKCE0.62341538
94TLK10.60725322
95PDPK10.59984149
96FYN0.58374827
97MAP4K20.57915543
98MAP3K130.56926347
99ILK0.56277520
100INSRR0.55790372
101RPS6KA20.55168035
102MAP2K20.52377830
103RPS6KA50.50441629
104CSNK1D0.49654794
105AKT30.48873310
106CDK80.48264966
107MAPK130.46773629
108PRKG10.46432687
109SGK20.45910712
110KSR20.45443630
111GSK3A0.44252221
112PRKCA0.44153125
113CSNK1A10.41621572
114NTRK20.41345776
115TAF10.40823447
116PAK10.40572187
117MAP3K120.39046022
118SRC0.37707419
119IRAK10.37576877
120STK110.37335030
121PRKACB0.36645202
122MAP3K40.35606497
123RPS6KA30.35065482
124FES0.34402314
125PIK3CA0.34364434
126ITK0.33907603
127GRK70.32970730
128CAMK1G0.32503828
129ADRBK20.32073644
130MAPK70.31997493
131PRKCH0.30696400
132DAPK30.30197903
133PDGFRB0.29122522
134MKNK10.28436169
135PDK10.27574964
136OBSCN0.27230304
137DMPK0.27157083
138PRKACA0.27151845
139GRK10.26795730
140INSR0.26574562
141PAK20.25593593
142CSNK1E0.25419796
143ROCK10.25182894
144BMX0.24657012
145DDR20.24049197
146MAPK100.23894421
147DYRK1A0.21471738

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.73052282
2Steroid biosynthesis_Homo sapiens_hsa001004.76794999
3Fatty acid elongation_Homo sapiens_hsa000624.48387972
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.65233149
5Ether lipid metabolism_Homo sapiens_hsa005653.10256790
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.90595571
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53686990
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.45843415
9Sulfur metabolism_Homo sapiens_hsa009202.12472898
10Insulin secretion_Homo sapiens_hsa049112.08741454
11Axon guidance_Homo sapiens_hsa043601.94954085
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94556189
13Oxidative phosphorylation_Homo sapiens_hsa001901.90360108
14Vitamin B6 metabolism_Homo sapiens_hsa007501.87285104
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86214422
16Protein export_Homo sapiens_hsa030601.85237816
17Sphingolipid metabolism_Homo sapiens_hsa006001.80607314
18Histidine metabolism_Homo sapiens_hsa003401.68836397
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66543746
20Linoleic acid metabolism_Homo sapiens_hsa005911.63092824
21Long-term potentiation_Homo sapiens_hsa047201.58416605
22Calcium signaling pathway_Homo sapiens_hsa040201.56461730
23Protein digestion and absorption_Homo sapiens_hsa049741.52809543
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.52066917
25Focal adhesion_Homo sapiens_hsa045101.51951626
26Butanoate metabolism_Homo sapiens_hsa006501.49805349
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46276955
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44023784
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43268343
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32749160
31Parkinsons disease_Homo sapiens_hsa050121.31597994
32Alzheimers disease_Homo sapiens_hsa050101.28630062
33Oxytocin signaling pathway_Homo sapiens_hsa049211.27008506
34Melanoma_Homo sapiens_hsa052181.26349160
35Serotonergic synapse_Homo sapiens_hsa047261.25738568
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24956917
37GABAergic synapse_Homo sapiens_hsa047271.21383278
38Hippo signaling pathway_Homo sapiens_hsa043901.21139208
39Glutamatergic synapse_Homo sapiens_hsa047241.21016360
40Olfactory transduction_Homo sapiens_hsa047401.20281337
41Nitrogen metabolism_Homo sapiens_hsa009101.20168522
42* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20070676
43Melanogenesis_Homo sapiens_hsa049161.18226529
44Renal cell carcinoma_Homo sapiens_hsa052111.16729148
45Arginine and proline metabolism_Homo sapiens_hsa003301.16129143
46TGF-beta signaling pathway_Homo sapiens_hsa043501.12010080
47Dilated cardiomyopathy_Homo sapiens_hsa054141.11493600
48Rap1 signaling pathway_Homo sapiens_hsa040151.09677750
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08990568
50Basal cell carcinoma_Homo sapiens_hsa052171.04168247
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02269077
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98784682
53Long-term depression_Homo sapiens_hsa047300.97447029
54Vibrio cholerae infection_Homo sapiens_hsa051100.97131637
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93751385
56Morphine addiction_Homo sapiens_hsa050320.93143733
57Collecting duct acid secretion_Homo sapiens_hsa049660.92844852
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92692646
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90152331
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90015408
61Thyroid hormone synthesis_Homo sapiens_hsa049180.88559012
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.87420783
63Wnt signaling pathway_Homo sapiens_hsa043100.86622067
64Proteoglycans in cancer_Homo sapiens_hsa052050.86197548
65Arachidonic acid metabolism_Homo sapiens_hsa005900.83742798
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81783239
67MAPK signaling pathway_Homo sapiens_hsa040100.80562817
68Glutathione metabolism_Homo sapiens_hsa004800.79867850
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77447528
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77029930
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76955260
72Endocytosis_Homo sapiens_hsa041440.76634433
73Estrogen signaling pathway_Homo sapiens_hsa049150.75992338
74Fatty acid metabolism_Homo sapiens_hsa012120.75895520
75Cocaine addiction_Homo sapiens_hsa050300.75755764
76* Tight junction_Homo sapiens_hsa045300.75380498
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73191751
78Rheumatoid arthritis_Homo sapiens_hsa053230.71819053
79Cardiac muscle contraction_Homo sapiens_hsa042600.71579284
80Ras signaling pathway_Homo sapiens_hsa040140.70236577
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.69951827
82Phototransduction_Homo sapiens_hsa047440.69569092
83Amoebiasis_Homo sapiens_hsa051460.69556769
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.69338191
85Autoimmune thyroid disease_Homo sapiens_hsa053200.68861654
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.68610899
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68394450
88Glioma_Homo sapiens_hsa052140.68347695
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67867967
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.67607149
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67279695
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.66647906
93Ovarian steroidogenesis_Homo sapiens_hsa049130.66170622
94Lysosome_Homo sapiens_hsa041420.65351559
95GnRH signaling pathway_Homo sapiens_hsa049120.64747150
96Dorso-ventral axis formation_Homo sapiens_hsa043200.62786954
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60324462
98Circadian entrainment_Homo sapiens_hsa047130.58691777
99Salivary secretion_Homo sapiens_hsa049700.58369988
100Huntingtons disease_Homo sapiens_hsa050160.58307828
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58112107
102ErbB signaling pathway_Homo sapiens_hsa040120.58103784
103Pathways in cancer_Homo sapiens_hsa052000.57985830
104Propanoate metabolism_Homo sapiens_hsa006400.57297937
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54633074
106Phagosome_Homo sapiens_hsa041450.53205257
107Fatty acid biosynthesis_Homo sapiens_hsa000610.52498630
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52469776
109Mineral absorption_Homo sapiens_hsa049780.52286819
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52213263
111Pancreatic secretion_Homo sapiens_hsa049720.50674863
112Gastric acid secretion_Homo sapiens_hsa049710.50011857
113Hedgehog signaling pathway_Homo sapiens_hsa043400.49834330
114Cholinergic synapse_Homo sapiens_hsa047250.49423606
115Dopaminergic synapse_Homo sapiens_hsa047280.49326195
116Nicotine addiction_Homo sapiens_hsa050330.47941952
117Peroxisome_Homo sapiens_hsa041460.47921140
118Folate biosynthesis_Homo sapiens_hsa007900.43524928
119Malaria_Homo sapiens_hsa051440.43521346
120ECM-receptor interaction_Homo sapiens_hsa045120.41917381
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41889700
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41766768
123Synaptic vesicle cycle_Homo sapiens_hsa047210.41591497
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41312096
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40791115
126Gap junction_Homo sapiens_hsa045400.40713408
127Metabolic pathways_Homo sapiens_hsa011000.40449849
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39852018
129Bile secretion_Homo sapiens_hsa049760.39692802
130Renin secretion_Homo sapiens_hsa049240.37373420
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35862091
132Vitamin digestion and absorption_Homo sapiens_hsa049770.35844341
133Prion diseases_Homo sapiens_hsa050200.34479036
134Choline metabolism in cancer_Homo sapiens_hsa052310.32578738
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31624390
136beta-Alanine metabolism_Homo sapiens_hsa004100.31425500
137Retinol metabolism_Homo sapiens_hsa008300.29856165
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29679533
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28176590
140cAMP signaling pathway_Homo sapiens_hsa040240.27672002
141Chemical carcinogenesis_Homo sapiens_hsa052040.26749103
142Tyrosine metabolism_Homo sapiens_hsa003500.24951468
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24830210
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24492736
145Taste transduction_Homo sapiens_hsa047420.23963790
146Amphetamine addiction_Homo sapiens_hsa050310.22512519

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