CLCN3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.65346258
2response to pheromone (GO:0019236)4.03280651
3detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.00175772
4regulation of cilium movement (GO:0003352)3.79705828
5negative regulation of transcription regulatory region DNA binding (GO:2000678)3.53725011
6fucose catabolic process (GO:0019317)3.43871230
7L-fucose metabolic process (GO:0042354)3.43871230
8L-fucose catabolic process (GO:0042355)3.43871230
9indolalkylamine metabolic process (GO:0006586)3.33514736
10regulation of meiosis I (GO:0060631)3.32688889
11detection of light stimulus involved in visual perception (GO:0050908)3.30297689
12detection of light stimulus involved in sensory perception (GO:0050962)3.30297689
13neural tube formation (GO:0001841)3.30256825
14retinal cone cell development (GO:0046549)3.29695490
15kynurenine metabolic process (GO:0070189)3.29536013
16nonmotile primary cilium assembly (GO:0035058)3.25310039
17cornea development in camera-type eye (GO:0061303)3.25050962
18limb bud formation (GO:0060174)3.21816106
19DNA double-strand break processing (GO:0000729)3.19134554
20tryptophan catabolic process (GO:0006569)3.17844037
21indole-containing compound catabolic process (GO:0042436)3.17844037
22indolalkylamine catabolic process (GO:0046218)3.17844037
23regulation of posttranscriptional gene silencing (GO:0060147)3.13817672
24regulation of gene silencing by miRNA (GO:0060964)3.13817672
25regulation of gene silencing by RNA (GO:0060966)3.13817672
26centriole replication (GO:0007099)3.13775282
27piRNA metabolic process (GO:0034587)3.09610450
28replication fork processing (GO:0031297)3.09438817
29protein K11-linked deubiquitination (GO:0035871)3.08817956
30respiratory chain complex IV assembly (GO:0008535)3.07662438
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05392065
32platelet dense granule organization (GO:0060155)3.04839628
33somite development (GO:0061053)3.02943895
34pyrimidine nucleobase catabolic process (GO:0006208)2.97332923
35tryptophan metabolic process (GO:0006568)2.94818553
36regulation of collateral sprouting (GO:0048670)2.94564723
37inner ear receptor stereocilium organization (GO:0060122)2.91373721
38photoreceptor cell maintenance (GO:0045494)2.86836704
39ketone body metabolic process (GO:1902224)2.86474884
40cellular ketone body metabolic process (GO:0046950)2.85837292
41protein polyglutamylation (GO:0018095)2.85835143
42reflex (GO:0060004)2.84535620
43regulation of nuclear cell cycle DNA replication (GO:0033262)2.82093646
44auditory receptor cell stereocilium organization (GO:0060088)2.80509455
45regulation of rhodopsin mediated signaling pathway (GO:0022400)2.78431606
46presynaptic membrane assembly (GO:0097105)2.78345178
47cilium morphogenesis (GO:0060271)2.77674243
48positive regulation of meiosis (GO:0045836)2.76529963
49DNA methylation involved in gamete generation (GO:0043046)2.75340570
50behavioral response to ethanol (GO:0048149)2.74173268
51regulation of microtubule-based movement (GO:0060632)2.72282350
52photoreceptor cell development (GO:0042461)2.71362770
53C4-dicarboxylate transport (GO:0015740)2.69714903
54indole-containing compound metabolic process (GO:0042430)2.69371199
55kidney morphogenesis (GO:0060993)2.69168227
56epithelial cilium movement (GO:0003351)2.69116550
57regulation of timing of cell differentiation (GO:0048505)2.66977933
58rhodopsin mediated signaling pathway (GO:0016056)2.66646204
59protein-cofactor linkage (GO:0018065)2.65838578
60regulation of action potential (GO:0098900)2.65050377
61gamma-aminobutyric acid transport (GO:0015812)2.63803842
62cytochrome complex assembly (GO:0017004)2.63744027
63neuronal action potential (GO:0019228)2.63555640
64regulation of glucokinase activity (GO:0033131)2.63338544
65regulation of hexokinase activity (GO:1903299)2.63338544
66negative regulation of telomere maintenance (GO:0032205)2.61165596
67negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60091419
68negative regulation of translation, ncRNA-mediated (GO:0040033)2.60091419
69regulation of translation, ncRNA-mediated (GO:0045974)2.60091419
70cilium organization (GO:0044782)2.59017720
71positive regulation of meiotic cell cycle (GO:0051446)2.58165003
72recombinational repair (GO:0000725)2.56187050
73regulation of telomere maintenance (GO:0032204)2.55600870
74double-strand break repair via homologous recombination (GO:0000724)2.55441674
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54718029
76eye photoreceptor cell development (GO:0042462)2.54120446
77protein complex biogenesis (GO:0070271)2.53808394
78reciprocal DNA recombination (GO:0035825)2.53729811
79reciprocal meiotic recombination (GO:0007131)2.53729811
80protein K6-linked ubiquitination (GO:0085020)2.53356671
81intraciliary transport (GO:0042073)2.53262050
82nucleobase catabolic process (GO:0046113)2.52920530
83nephron tubule morphogenesis (GO:0072078)2.50265626
84nephron epithelium morphogenesis (GO:0072088)2.50265626
85water-soluble vitamin biosynthetic process (GO:0042364)2.49310256
86hindbrain development (GO:0030902)2.49056230
87mitochondrial respiratory chain complex I assembly (GO:0032981)2.49022706
88NADH dehydrogenase complex assembly (GO:0010257)2.49022706
89mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49022706
90detection of mechanical stimulus involved in sensory perception (GO:0050974)2.47099860
91multicellular organism reproduction (GO:0032504)2.46820452
92cilium assembly (GO:0042384)2.45692944
93regulation of hippo signaling (GO:0035330)2.44033452
94embryonic epithelial tube formation (GO:0001838)2.43904828
95axoneme assembly (GO:0035082)2.43417372
96oxidative demethylation (GO:0070989)2.42361926
97presynaptic membrane organization (GO:0097090)2.40701072
98microtubule anchoring (GO:0034453)2.40681719
99neurotransmitter-gated ion channel clustering (GO:0072578)2.39686119
100protein localization to cilium (GO:0061512)2.38630970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.70200223
2EZH2_22144423_ChIP-Seq_EOC_Human3.47630726
3GBX2_23144817_ChIP-Seq_PC3_Human3.37530552
4VDR_22108803_ChIP-Seq_LS180_Human3.11958479
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.88434748
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80280687
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.79178853
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.58108436
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55989320
10IGF1R_20145208_ChIP-Seq_DFB_Human2.40837698
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.38528319
12P300_19829295_ChIP-Seq_ESCs_Human2.20042079
13FUS_26573619_Chip-Seq_HEK293_Human2.14609944
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13175523
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09624942
16EWS_26573619_Chip-Seq_HEK293_Human2.09188450
17TAF15_26573619_Chip-Seq_HEK293_Human2.06459133
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.96004512
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84672312
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78066007
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77657866
22ER_23166858_ChIP-Seq_MCF-7_Human1.76016742
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75671943
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75659636
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68782466
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.68782466
27SMAD4_21799915_ChIP-Seq_A2780_Human1.66144593
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62578816
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.59846548
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58406585
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58183375
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56779770
33CBP_20019798_ChIP-Seq_JUKART_Human1.56779770
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56559567
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.56079870
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53871935
37TCF4_23295773_ChIP-Seq_U87_Human1.53678202
38STAT3_23295773_ChIP-Seq_U87_Human1.53224998
39AR_25329375_ChIP-Seq_VCAP_Human1.52431406
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49403300
41NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47539418
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46342814
43IRF1_19129219_ChIP-ChIP_H3396_Human1.44746158
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44568517
45BCAT_22108803_ChIP-Seq_LS180_Human1.43603354
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41740844
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40657419
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39122104
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.38250618
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37731280
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.36721532
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36045715
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35038034
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.34472845
55AR_21572438_ChIP-Seq_LNCaP_Human1.33574795
56TP53_22573176_ChIP-Seq_HFKS_Human1.32998264
57RUNX2_22187159_ChIP-Seq_PCA_Human1.31487299
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.29202601
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27970487
60TCF4_22108803_ChIP-Seq_LS180_Human1.26839273
61MYC_18940864_ChIP-ChIP_HL60_Human1.26746131
62REST_21632747_ChIP-Seq_MESCs_Mouse1.26283063
63RNF2_27304074_Chip-Seq_NSC_Mouse1.24385161
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.22972023
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22676390
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22100098
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21836031
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20167618
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.18613798
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.18525961
71SOX2_19829295_ChIP-Seq_ESCs_Human1.17842955
72NANOG_19829295_ChIP-Seq_ESCs_Human1.17842955
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17299541
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.16718076
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16697149
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16492172
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.15423249
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15298049
79KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14943106
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.13680863
81CRX_20693478_ChIP-Seq_RETINA_Mouse1.12325278
82P53_22387025_ChIP-Seq_ESCs_Mouse1.12169594
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11917351
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.11917351
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07995467
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05531246
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04830992
88ELK1_19687146_ChIP-ChIP_HELA_Human1.04421649
89TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02702313
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01633609
91POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00460134
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.00432922
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00123045
94STAT3_18555785_Chip-Seq_ESCs_Mouse0.99930979
95SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98892731
96SOX2_21211035_ChIP-Seq_LN229_Gbm0.98108381
97AR_20517297_ChIP-Seq_VCAP_Human0.96370414
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94101007
99HOXB7_26014856_ChIP-Seq_BT474_Human0.93976918
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93677168

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.17413098
2MP0005551_abnormal_eye_electrophysiolog2.57902049
3MP0003646_muscle_fatigue2.49683692
4MP0002102_abnormal_ear_morphology2.45557424
5MP0006292_abnormal_olfactory_placode2.37958929
6MP0003195_calcinosis2.29224639
7MP0000372_irregular_coat_pigmentation2.28944114
8MP0008872_abnormal_physiological_respon2.24014892
9MP0003880_abnormal_central_pattern2.18201983
10MP0002736_abnormal_nociception_after2.12901157
11MP0006072_abnormal_retinal_apoptosis2.12873501
12MP0001968_abnormal_touch/_nociception2.11164620
13MP0004885_abnormal_endolymph2.10508255
14MP0003787_abnormal_imprinting2.09929633
15MP0001984_abnormal_olfaction1.92521848
16MP0000569_abnormal_digit_pigmentation1.87607496
17MP0002938_white_spotting1.84048083
18MP0005253_abnormal_eye_physiology1.77883388
19MP0009745_abnormal_behavioral_response1.77690390
20MP0004142_abnormal_muscle_tone1.75593707
21MP0006276_abnormal_autonomic_nervous1.73622132
22MP0005645_abnormal_hypothalamus_physiol1.71299551
23MP0004133_heterotaxia1.70317414
24MP0004043_abnormal_pH_regulation1.69853505
25MP0002837_dystrophic_cardiac_calcinosis1.69492839
26MP0001485_abnormal_pinna_reflex1.68766604
27MP0002272_abnormal_nervous_system1.65911973
28MP0000427_abnormal_hair_cycle1.62680654
29MP0000631_abnormal_neuroendocrine_gland1.61753115
30MP0001529_abnormal_vocalization1.57055038
31MP0001486_abnormal_startle_reflex1.55181606
32MP0009046_muscle_twitch1.46928672
33MP0002234_abnormal_pharynx_morphology1.37998944
34MP0002163_abnormal_gland_morphology1.37240094
35MP0003283_abnormal_digestive_organ1.36312395
36MP0003136_yellow_coat_color1.36266515
37MP0003121_genomic_imprinting1.36210402
38MP0001986_abnormal_taste_sensitivity1.35077076
39MP0005084_abnormal_gallbladder_morpholo1.34579084
40MP0008789_abnormal_olfactory_epithelium1.31920139
41MP0002638_abnormal_pupillary_reflex1.26079158
42MP0002572_abnormal_emotion/affect_behav1.26015633
43MP0003718_maternal_effect1.25091639
44MP0002751_abnormal_autonomic_nervous1.25025942
45MP0001501_abnormal_sleep_pattern1.23980848
46MP0004215_abnormal_myocardial_fiber1.23511676
47MP0002557_abnormal_social/conspecific_i1.23039988
48MP0002735_abnormal_chemical_nociception1.22830458
49MP0000778_abnormal_nervous_system1.21479736
50MP0002876_abnormal_thyroid_physiology1.18602402
51MP0005646_abnormal_pituitary_gland1.16771898
52MP0005195_abnormal_posterior_eye1.15658286
53MP0005174_abnormal_tail_pigmentation1.15170098
54MP0008875_abnormal_xenobiotic_pharmacok1.14875477
55MP0002067_abnormal_sensory_capabilities1.14543450
56MP0002064_seizures1.12813393
57MP0002734_abnormal_mechanical_nocicepti1.12093326
58MP0005386_behavior/neurological_phenoty1.08982397
59MP0004924_abnormal_behavior1.08982397
60MP0003698_abnormal_male_reproductive1.07204188
61MP0003567_abnormal_fetal_cardiomyocyte1.06496867
62MP0004742_abnormal_vestibular_system1.05941371
63MP0003122_maternal_imprinting1.05101732
64MP0010386_abnormal_urinary_bladder1.01820207
65MP0003635_abnormal_synaptic_transmissio1.01711733
66MP0002095_abnormal_skin_pigmentation1.01222778
67MP0002277_abnormal_respiratory_mucosa0.99699929
68MP0002210_abnormal_sex_determination0.99353322
69MP0004145_abnormal_muscle_electrophysio0.98931865
70MP0000647_abnormal_sebaceous_gland0.98872166
71MP0002653_abnormal_ependyma_morphology0.98355617
72MP0003137_abnormal_impulse_conducting0.98129832
73MP0001970_abnormal_pain_threshold0.97738629
74MP0005379_endocrine/exocrine_gland_phen0.97143429
75MP0001929_abnormal_gametogenesis0.96957049
76MP0002184_abnormal_innervation0.96261645
77MP0003890_abnormal_embryonic-extraembry0.96174851
78MP0002752_abnormal_somatic_nervous0.96112553
79MP0000026_abnormal_inner_ear0.95899018
80MP0002063_abnormal_learning/memory/cond0.95480885
81MP0008058_abnormal_DNA_repair0.95215742
82MP0004147_increased_porphyrin_level0.95098082
83MP0002733_abnormal_thermal_nociception0.94845112
84MP0001324_abnormal_eye_pigmentation0.93865580
85MP0002928_abnormal_bile_duct0.93088054
86MP0002160_abnormal_reproductive_system0.91430161
87MP0000015_abnormal_ear_pigmentation0.91202966
88MP0003119_abnormal_digestive_system0.90247522
89MP0005410_abnormal_fertilization0.88976667
90MP0000383_abnormal_hair_follicle0.85923776
91MP0003950_abnormal_plasma_membrane0.84588956
92MP0008775_abnormal_heart_ventricle0.84357963
93MP0005389_reproductive_system_phenotype0.83973466
94MP0001963_abnormal_hearing_physiology0.81986035
95MP0002233_abnormal_nose_morphology0.80425127
96MP0003937_abnormal_limbs/digits/tail_de0.79151142
97MP0005394_taste/olfaction_phenotype0.79023369
98MP0005499_abnormal_olfactory_system0.79023369
99MP0000653_abnormal_sex_gland0.78947098
100MP0004085_abnormal_heartbeat0.77616538

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.08411888
2Abnormality of midbrain morphology (HP:0002418)3.85990996
3Molar tooth sign on MRI (HP:0002419)3.85990996
4Nephronophthisis (HP:0000090)3.65627537
5Pancreatic fibrosis (HP:0100732)3.62780637
6True hermaphroditism (HP:0010459)3.55276187
7Abnormality of the renal cortex (HP:0011035)3.34872083
8Abnormality of the renal medulla (HP:0100957)3.28837784
9Congenital stationary night blindness (HP:0007642)3.17414732
10Medial flaring of the eyebrow (HP:0010747)3.03516457
11Type II lissencephaly (HP:0007260)3.00744438
12Hyperventilation (HP:0002883)2.93319712
13Intestinal atresia (HP:0011100)2.83311180
14Attenuation of retinal blood vessels (HP:0007843)2.81198247
15Abnormality of the labia minora (HP:0012880)2.59126332
16Tubular atrophy (HP:0000092)2.58385049
17Gait imbalance (HP:0002141)2.52507267
18Lissencephaly (HP:0001339)2.52373943
19Congenital, generalized hypertrichosis (HP:0004540)2.48669360
20Abolished electroretinogram (ERG) (HP:0000550)2.48206992
21Cystic liver disease (HP:0006706)2.47183186
22Progressive inability to walk (HP:0002505)2.46544526
23Chronic hepatic failure (HP:0100626)2.43155522
24Abnormal rod and cone electroretinograms (HP:0008323)2.42754510
25Methylmalonic acidemia (HP:0002912)2.41042660
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.40894090
27Congenital primary aphakia (HP:0007707)2.36605926
28Pachygyria (HP:0001302)2.35069048
29Abnormal drinking behavior (HP:0030082)2.35015803
30Polydipsia (HP:0001959)2.35015803
31Inability to walk (HP:0002540)2.34362595
32Large for gestational age (HP:0001520)2.32800077
33Nephrogenic diabetes insipidus (HP:0009806)2.31629870
34Focal motor seizures (HP:0011153)2.29647587
35Bony spicule pigmentary retinopathy (HP:0007737)2.26672273
36Febrile seizures (HP:0002373)2.20000502
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.19806370
38Sclerocornea (HP:0000647)2.18672716
39Keratoconus (HP:0000563)2.18065338
40Increased corneal curvature (HP:0100692)2.18065338
41Protruding tongue (HP:0010808)2.17447589
42Renal cortical cysts (HP:0000803)2.17389786
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17071981
44Genital tract atresia (HP:0001827)2.14871780
45Increased CSF lactate (HP:0002490)2.13072779
46Broad-based gait (HP:0002136)2.11961266
47Congenital hepatic fibrosis (HP:0002612)2.11460890
48Mitochondrial inheritance (HP:0001427)2.11406198
49Hemiparesis (HP:0001269)2.08791466
50Polyuria (HP:0000103)2.08481571
51Anencephaly (HP:0002323)2.08070937
52Vaginal atresia (HP:0000148)2.06106250
53Cerebellar dysplasia (HP:0007033)2.03225754
54Acute necrotizing encephalopathy (HP:0006965)2.02255413
55Methylmalonic aciduria (HP:0012120)2.01247795
56Hypoplasia of the fovea (HP:0007750)1.99823434
57Aplasia/Hypoplasia of the fovea (HP:0008060)1.99823434
58Decreased central vision (HP:0007663)1.96648767
59Abnormality of the ileum (HP:0001549)1.96647115
60Widely spaced teeth (HP:0000687)1.95223493
61Abnormality of alanine metabolism (HP:0010916)1.94572310
62Hyperalaninemia (HP:0003348)1.94572310
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94572310
64Meckel diverticulum (HP:0002245)1.93987864
65Concave nail (HP:0001598)1.93751011
66Gaze-evoked nystagmus (HP:0000640)1.93257615
67Oligodactyly (hands) (HP:0001180)1.92478812
68Postaxial foot polydactyly (HP:0001830)1.92285054
69Hypoplastic iliac wings (HP:0002866)1.91928486
70Astigmatism (HP:0000483)1.91561244
71Tubulointerstitial abnormality (HP:0001969)1.90503982
72Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90337165
73Gastrointestinal atresia (HP:0002589)1.88997008
74Optic nerve hypoplasia (HP:0000609)1.88044821
75Tubulointerstitial fibrosis (HP:0005576)1.87467777
76Progressive macrocephaly (HP:0004481)1.86674303
77Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86545333
78Pendular nystagmus (HP:0012043)1.86130111
79Small hand (HP:0200055)1.85883480
80Severe muscular hypotonia (HP:0006829)1.84434230
81Optic disc pallor (HP:0000543)1.84185819
82Postaxial hand polydactyly (HP:0001162)1.82407038
83Volvulus (HP:0002580)1.80945624
84Preaxial hand polydactyly (HP:0001177)1.80433391
85Focal seizures (HP:0007359)1.80292522
86Narrow forehead (HP:0000341)1.78392021
87Poor coordination (HP:0002370)1.78366624
88Lipid accumulation in hepatocytes (HP:0006561)1.77527975
89Absent speech (HP:0001344)1.76998935
90Abnormality of macular pigmentation (HP:0008002)1.76124194
91Male pseudohermaphroditism (HP:0000037)1.75980405
92Hepatocellular necrosis (HP:0001404)1.75016327
93Increased hepatocellular lipid droplets (HP:0006565)1.74758950
94Dandy-Walker malformation (HP:0001305)1.74674031
95Furrowed tongue (HP:0000221)1.74420414
96Sloping forehead (HP:0000340)1.74174942
97Abnormality of the duodenum (HP:0002246)1.71171047
98Patellar aplasia (HP:0006443)1.69624633
99Aganglionic megacolon (HP:0002251)1.68881533
100Abnormality of the fovea (HP:0000493)1.68622760

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.05755655
2WNK33.35524599
3BMPR1B2.71337798
4ADRBK22.67604147
5PINK12.60707100
6MAPK132.56509404
7MAP4K22.54669071
8ACVR1B2.31843665
9MARK12.31552089
10NUAK12.30199009
11TAF12.20417229
12ZAK2.13286241
13TNIK2.00651067
14MAP3K41.94916978
15GRK11.91459761
16PNCK1.86585725
17CASK1.80200971
18TAOK31.65713684
19WNK41.60436252
20STK391.59117601
21AKT31.52369541
22INSRR1.47097292
23PAK31.42625970
24MKNK21.39905789
25BRSK21.27374929
26WEE11.24852427
27PLK21.23187552
28STK38L1.17111055
29PRKCE1.15074365
30OXSR11.14385045
31TLK11.13825206
32NTRK31.12444326
33TRIM281.12141663
34ERBB31.10343617
35DYRK21.09536950
36PHKG21.09397095
37PHKG11.09397095
38EPHA41.04900913
39BCR0.98353757
40PRKCG0.97847282
41PLK40.94273277
42MARK30.92826003
43PTK2B0.91506174
44ADRBK10.91125912
45FLT30.90832930
46VRK10.89965126
47MST40.88334300
48PLK30.88152375
49PDK20.84317898
50MAP2K70.83330429
51CCNB10.81905169
52CSNK1G10.81239298
53FGFR20.80881301
54PRKCI0.79337103
55EIF2AK30.77449886
56SIK20.77340803
57OBSCN0.77233760
58MAP2K60.76275340
59NTRK20.74939475
60NEK10.74201466
61TGFBR10.68243624
62DAPK20.68144227
63NEK20.65084976
64PKN10.64191722
65CSNK1G20.63713123
66MKNK10.63435627
67CDK30.63037910
68BCKDK0.62097277
69CAMKK20.59853299
70CAMK2A0.59492219
71PLK10.58466658
72MAPKAPK50.56656201
73SGK20.54662735
74STK110.54552880
75PIK3CG0.54157448
76TIE10.52618060
77EPHA30.52533755
78CSNK1G30.52263364
79CDK80.52199489
80IRAK40.50996215
81PRKCQ0.49756837
82PRKG10.48941166
83MAPKAPK30.48036819
84PIK3CA0.47068621
85PRKACA0.46549334
86PRKCZ0.43242706
87NLK0.41563636
88CSNK1A1L0.39311351
89CHEK20.39200229
90PRKAA10.39198111
91CSNK1D0.38764500
92LMTK20.37362664
93CSNK1A10.37323086
94DYRK1A0.36230639
95MAP2K40.35332883
96STK30.35290168
97SIK30.34061538
98ATM0.32013749
99FGFR10.31105564
100CDC70.29869410

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.32385238
2Butanoate metabolism_Homo sapiens_hsa006502.74734272
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72452876
4Selenocompound metabolism_Homo sapiens_hsa004502.39110436
5Linoleic acid metabolism_Homo sapiens_hsa005912.38255105
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27358851
7Nitrogen metabolism_Homo sapiens_hsa009102.21570022
8Protein export_Homo sapiens_hsa030602.21116572
9Basal transcription factors_Homo sapiens_hsa030222.02721594
10Nicotine addiction_Homo sapiens_hsa050332.01875698
11Fanconi anemia pathway_Homo sapiens_hsa034601.96959057
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95099205
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.94033241
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92970784
15Oxidative phosphorylation_Homo sapiens_hsa001901.89276598
16Propanoate metabolism_Homo sapiens_hsa006401.88856000
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.87874610
18Homologous recombination_Homo sapiens_hsa034401.81149793
19Tryptophan metabolism_Homo sapiens_hsa003801.80091493
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72532548
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64954204
22Caffeine metabolism_Homo sapiens_hsa002321.64755240
23Olfactory transduction_Homo sapiens_hsa047401.62641275
24Ether lipid metabolism_Homo sapiens_hsa005651.62484325
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61575359
26Parkinsons disease_Homo sapiens_hsa050121.54085886
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53140884
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43176394
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40605998
30Taste transduction_Homo sapiens_hsa047421.37228076
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.32738284
32RNA degradation_Homo sapiens_hsa030181.30492424
33Regulation of autophagy_Homo sapiens_hsa041401.30012894
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28133915
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24807199
36Morphine addiction_Homo sapiens_hsa050321.22721449
37Chemical carcinogenesis_Homo sapiens_hsa052041.20637448
38Circadian rhythm_Homo sapiens_hsa047101.10190699
39Serotonergic synapse_Homo sapiens_hsa047261.08509256
40Circadian entrainment_Homo sapiens_hsa047131.08120525
41Glutamatergic synapse_Homo sapiens_hsa047241.07830218
42Peroxisome_Homo sapiens_hsa041461.07661964
43Cardiac muscle contraction_Homo sapiens_hsa042601.04333061
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.04145522
45Insulin secretion_Homo sapiens_hsa049111.03569615
46Huntingtons disease_Homo sapiens_hsa050160.99497655
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98220144
48Steroid biosynthesis_Homo sapiens_hsa001000.96338204
49Alzheimers disease_Homo sapiens_hsa050100.95707447
50Non-homologous end-joining_Homo sapiens_hsa034500.94484486
51RNA polymerase_Homo sapiens_hsa030200.94348044
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92534220
53GABAergic synapse_Homo sapiens_hsa047270.92296157
54ABC transporters_Homo sapiens_hsa020100.92007924
55beta-Alanine metabolism_Homo sapiens_hsa004100.91524905
56One carbon pool by folate_Homo sapiens_hsa006700.90741379
57Fatty acid elongation_Homo sapiens_hsa000620.89735658
58Retinol metabolism_Homo sapiens_hsa008300.83587019
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83005832
60Long-term depression_Homo sapiens_hsa047300.82775558
61Arachidonic acid metabolism_Homo sapiens_hsa005900.80422877
62Calcium signaling pathway_Homo sapiens_hsa040200.76720269
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.74693573
64Dopaminergic synapse_Homo sapiens_hsa047280.71792209
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71529896
66Salivary secretion_Homo sapiens_hsa049700.69945353
67Collecting duct acid secretion_Homo sapiens_hsa049660.68888896
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68310582
69Lysine degradation_Homo sapiens_hsa003100.67642494
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66317595
71Fat digestion and absorption_Homo sapiens_hsa049750.64597846
72Glycerolipid metabolism_Homo sapiens_hsa005610.64524360
73Hedgehog signaling pathway_Homo sapiens_hsa043400.63627718
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63082369
75Ovarian steroidogenesis_Homo sapiens_hsa049130.60983431
76Purine metabolism_Homo sapiens_hsa002300.58524771
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57833097
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57706859
79Proteasome_Homo sapiens_hsa030500.55085142
80Metabolic pathways_Homo sapiens_hsa011000.54066317
81Fatty acid degradation_Homo sapiens_hsa000710.53888734
82Dorso-ventral axis formation_Homo sapiens_hsa043200.52451953
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47116076
84Histidine metabolism_Homo sapiens_hsa003400.46694240
85Gastric acid secretion_Homo sapiens_hsa049710.44269854
86cAMP signaling pathway_Homo sapiens_hsa040240.43876277
87Amphetamine addiction_Homo sapiens_hsa050310.43650165
88Basal cell carcinoma_Homo sapiens_hsa052170.42549130
89Nucleotide excision repair_Homo sapiens_hsa034200.42465742
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.41017531
91Oocyte meiosis_Homo sapiens_hsa041140.39280379
92Mismatch repair_Homo sapiens_hsa034300.38599378
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37826877
94TGF-beta signaling pathway_Homo sapiens_hsa043500.37115695
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.36712828
96Oxytocin signaling pathway_Homo sapiens_hsa049210.36127766
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35961031
98Cholinergic synapse_Homo sapiens_hsa047250.34337115
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34111350
100Arginine and proline metabolism_Homo sapiens_hsa003300.33760352

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