CLASRP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.61992110
2locomotory exploration behavior (GO:0035641)4.44947049
3mannose metabolic process (GO:0006013)4.17366242
4synaptic vesicle maturation (GO:0016188)4.17107589
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.05925990
6negative regulation of cell killing (GO:0031342)4.05925990
7response to muramyl dipeptide (GO:0032495)4.01081566
8sodium ion export (GO:0071436)3.97049270
9response to peptidoglycan (GO:0032494)3.90830242
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.89286326
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.89286326
12modulation by symbiont of host immune response (GO:0052553)3.89286326
13positive regulation by symbiont of host defense response (GO:0052509)3.89286326
14modulation by symbiont of host defense response (GO:0052031)3.89286326
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.89286326
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.81390116
17intracellular estrogen receptor signaling pathway (GO:0030520)3.75613553
18cytoskeletal anchoring at plasma membrane (GO:0007016)3.73827504
19pre-miRNA processing (GO:0031054)3.68108962
20positive thymic T cell selection (GO:0045059)3.68102227
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.67830572
22antigen processing and presentation of endogenous antigen (GO:0019883)3.66455013
23regulation of ARF GTPase activity (GO:0032312)3.65191148
24regulation of gamma-delta T cell activation (GO:0046643)3.56265656
25histone H4-K12 acetylation (GO:0043983)3.53375025
26regulation of short-term neuronal synaptic plasticity (GO:0048172)3.48353038
27detection of bacterium (GO:0016045)3.48212689
28positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.47829259
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.47039105
30thymic T cell selection (GO:0045061)3.46802772
31germinal center formation (GO:0002467)3.46295765
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43748422
33antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.42628273
34detection of other organism (GO:0098543)3.42486596
35macrophage activation involved in immune response (GO:0002281)3.42004499
36NIK/NF-kappaB signaling (GO:0038061)3.40871117
37membrane tubulation (GO:0097320)3.34609668
38histone H4-K8 acetylation (GO:0043982)3.27723089
39histone H4-K5 acetylation (GO:0043981)3.27723089
403-UTR-mediated mRNA stabilization (GO:0070935)3.27013291
41chromatin silencing (GO:0006342)3.26477462
42positive regulation of histone deacetylation (GO:0031065)3.25540061
43regulation of gamma-delta T cell differentiation (GO:0045586)3.25377093
44B cell receptor signaling pathway (GO:0050853)3.24731475
45negative regulation of gene expression, epigenetic (GO:0045814)3.24467849
46regulation of T-helper 2 cell differentiation (GO:0045628)3.23406178
47leukocyte aggregation (GO:0070486)3.21773246
48mitotic G1 DNA damage checkpoint (GO:0031571)3.21699856
49regulation of NFAT protein import into nucleus (GO:0051532)3.15156844
50histone H3-K4 trimethylation (GO:0080182)3.14724643
51negative regulation of mRNA processing (GO:0050686)3.14712411
52cerebellar Purkinje cell differentiation (GO:0021702)3.12441641
53positive regulation of gene expression, epigenetic (GO:0045815)3.10986264
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10570260
55regulation of histone H3-K27 methylation (GO:0061085)3.10154306
56T cell selection (GO:0045058)3.09071938
57neutrophil activation involved in immune response (GO:0002283)3.06684887
58nucleosome disassembly (GO:0006337)2.99676572
59protein-DNA complex disassembly (GO:0032986)2.99676572
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.99671208
61histone H4-K16 acetylation (GO:0043984)2.98597145
62negative regulation of RNA splicing (GO:0033119)2.97663147
63regulation of translational fidelity (GO:0006450)2.97477310
64regulation of leukocyte degranulation (GO:0043300)2.97107476
65regulation of type I interferon-mediated signaling pathway (GO:0060338)2.95535675
66neuromuscular process controlling balance (GO:0050885)2.94471491
67negative thymic T cell selection (GO:0045060)2.93510512
68regulation of B cell receptor signaling pathway (GO:0050855)2.93280315
69regulation of myeloid leukocyte mediated immunity (GO:0002886)2.93013762
70positive regulation of B cell differentiation (GO:0045579)2.92630540
71immunoglobulin mediated immune response (GO:0016064)2.91515998
72histone H3-K36 demethylation (GO:0070544)2.91427099
73modulation by virus of host process (GO:0019054)2.90292966
74regulation of mast cell degranulation (GO:0043304)2.89539370
75positive regulation of Rap GTPase activity (GO:0032854)2.86844379
76modulation by symbiont of host cellular process (GO:0044068)2.86699833
77negative regulation of nucleotide catabolic process (GO:0030812)2.85515661
78regulation of interferon-beta biosynthetic process (GO:0045357)2.85274764
79cellular potassium ion homeostasis (GO:0030007)2.84628708
80regulation of chromatin binding (GO:0035561)2.84482433
81negative regulation of cell size (GO:0045792)2.82793026
82peptidyl-lysine dimethylation (GO:0018027)2.82261008
83synaptic vesicle docking involved in exocytosis (GO:0016081)2.82145720
84detection of external biotic stimulus (GO:0098581)2.81837902
85glycine transport (GO:0015816)2.80721256
86regulation of synapse structural plasticity (GO:0051823)2.80367972
87response to laminar fluid shear stress (GO:0034616)2.79747068
88positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79353492
89negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.79166782
90positive T cell selection (GO:0043368)2.78638865
91defense response to protozoan (GO:0042832)2.78285736
92negative regulation of mRNA metabolic process (GO:1903312)2.77897099
93establishment of nucleus localization (GO:0040023)2.77462329
94negative regulation of GTP catabolic process (GO:0033125)2.77013118
95negative regulation of GTPase activity (GO:0034260)2.77013118
96mitotic G1/S transition checkpoint (GO:0044819)2.76715361
97histone H3-K4 methylation (GO:0051568)2.74310619
98negative regulation of interleukin-12 production (GO:0032695)2.73655728
99positive regulation of synapse maturation (GO:0090129)2.73387500
100mRNA splice site selection (GO:0006376)2.72145134
101negative regulation of toll-like receptor signaling pathway (GO:0034122)2.71601928
102regulation of Rap GTPase activity (GO:0032317)2.70844484
103lipopolysaccharide-mediated signaling pathway (GO:0031663)2.69305371
104regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.69299185
105histone H4 deacetylation (GO:0070933)2.68842743
106dendritic spine morphogenesis (GO:0060997)2.68594524
107positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68557998
108negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.67964749
109Peyers patch development (GO:0048541)2.67425085
110mucosal-associated lymphoid tissue development (GO:0048537)2.67425085
111negative T cell selection (GO:0043383)2.67243441
112activation of MAPKKK activity (GO:0000185)2.67163045
113neuromuscular process controlling posture (GO:0050884)2.66819700
114apoptotic process involved in morphogenesis (GO:0060561)2.65914955
115dosage compensation (GO:0007549)2.65846575
116positive regulation of Cdc42 GTPase activity (GO:0043089)2.65312789
117neuronal ion channel clustering (GO:0045161)2.65267733
118regulation of necroptotic process (GO:0060544)2.64138819
119heterochromatin organization (GO:0070828)2.63912481
120negative regulation of erythrocyte differentiation (GO:0045647)2.63722211
121layer formation in cerebral cortex (GO:0021819)2.62859686
122response to protozoan (GO:0001562)2.62401906
123cell communication by electrical coupling (GO:0010644)2.60774231
124negative regulation of myotube differentiation (GO:0010832)2.59523069
125negative regulation of organelle assembly (GO:1902116)2.58669254
126negative regulation of histone methylation (GO:0031061)2.56605815
127CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.55874694
128negative regulation of leukocyte mediated immunity (GO:0002704)2.55503046
129response to type I interferon (GO:0034340)2.55347296
130cellular extravasation (GO:0045123)2.55010987
131regulation of B cell differentiation (GO:0045577)2.54937865
132establishment of apical/basal cell polarity (GO:0035089)2.54581673
133cellular response to virus (GO:0098586)2.53692937
134negative regulation of purine nucleotide catabolic process (GO:0033122)2.53513917
135type I interferon signaling pathway (GO:0060337)2.53469760
136cellular response to type I interferon (GO:0071357)2.53469760
137response to host (GO:0075136)2.53149155
138response to host defenses (GO:0052200)2.53149155
139response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.53149155
140signal complex assembly (GO:0007172)2.53066735
141cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.52940745
142potassium ion import (GO:0010107)2.52596417
143positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.52274338
144peptidyl-lysine trimethylation (GO:0018023)2.51954362
145regulation of ARF protein signal transduction (GO:0032012)2.51672606
146response to host immune response (GO:0052572)2.51230786
147response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.51230786
148negative regulation of lymphocyte mediated immunity (GO:0002707)2.50910236
149exploration behavior (GO:0035640)2.50848780
150detection of biotic stimulus (GO:0009595)2.50724323
151regulation of mast cell activation involved in immune response (GO:0033006)2.50056752
152poly(A)+ mRNA export from nucleus (GO:0016973)2.49845290
153response to pheromone (GO:0019236)2.48266887
154activation of JUN kinase activity (GO:0007257)2.48235008
155embryonic process involved in female pregnancy (GO:0060136)2.47759253
156G1 DNA damage checkpoint (GO:0044783)2.47549877
157establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.47352615
158positive regulation of RNA splicing (GO:0033120)2.46443903
159negative regulation of innate immune response (GO:0045824)2.46236569
160tolerance induction (GO:0002507)2.45749290
161stress granule assembly (GO:0034063)2.44494669
162positive regulation of type 2 immune response (GO:0002830)2.43802329
163negative regulation of granulocyte differentiation (GO:0030853)2.43469252
164regulation of neuronal synaptic plasticity (GO:0048168)2.42558434
165regulation of glutamate receptor signaling pathway (GO:1900449)2.42507920
166synaptic vesicle endocytosis (GO:0048488)2.40684639
167peptidyl-lysine methylation (GO:0018022)2.39796443
168cell migration in hindbrain (GO:0021535)2.39483713
169histone H3 deacetylation (GO:0070932)2.38729039
170spliceosomal tri-snRNP complex assembly (GO:0000244)2.37767607
171histone H4 acetylation (GO:0043967)2.37652080
172regulation of translational termination (GO:0006449)2.36854384
173glutamate secretion (GO:0014047)2.34765310
174negative regulation of cytosolic calcium ion concentration (GO:0051481)2.33457206
175regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.32011922
176cell-cell junction maintenance (GO:0045217)2.31714779
177membrane depolarization during action potential (GO:0086010)2.31224434
178synaptic vesicle exocytosis (GO:0016079)2.30068182
179histone lysine methylation (GO:0034968)2.30062569
180G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.29872941
181long-term memory (GO:0007616)2.29248539
182positive regulation of protein deacetylation (GO:0090312)2.29078929
183auditory behavior (GO:0031223)2.27706483
184potassium ion homeostasis (GO:0055075)2.27580403
185positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.26916511
186establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.25544848
187mitochondrion transport along microtubule (GO:0047497)2.25544848
188regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.25146076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.62529962
2MYC_22102868_ChIP-Seq_BL_Human3.33075033
3VDR_21846776_ChIP-Seq_THP-1_Human2.88466764
4KDM2B_26808549_Chip-Seq_DND41_Human2.80835834
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.79135190
6LXR_22292898_ChIP-Seq_THP-1_Human2.56951329
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.56739213
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.50730780
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.46679941
10TCF7_22412390_ChIP-Seq_EML_Mouse2.37249724
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.37134082
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35167355
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.34570688
14KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.31443737
15ZFP281_27345836_Chip-Seq_ESCs_Mouse2.27029432
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.14139696
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.12446182
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.12407980
19KDM2B_26808549_Chip-Seq_K562_Human2.07310661
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97888426
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95776124
22KDM2B_26808549_Chip-Seq_JURKAT_Human1.92802767
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.92189753
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87194046
25P68_20966046_ChIP-Seq_HELA_Human1.84444624
26EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.83092362
27DNAJC2_21179169_ChIP-ChIP_NT2_Human1.77123642
28EZH2_22144423_ChIP-Seq_EOC_Human1.76997666
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.76736312
30DROSHA_22980978_ChIP-Seq_HELA_Human1.75322144
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.73532301
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73048732
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71006528
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69388134
35GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67391911
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66680516
37CIITA_25753668_ChIP-Seq_RAJI_Human1.63827487
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.61364359
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60455559
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60335184
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59900860
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59498487
43UTX_26944678_Chip-Seq_JUKART_Human1.58979085
44RACK7_27058665_Chip-Seq_MCF-7_Human1.58557283
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58395529
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.56497691
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54748619
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54241101
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53681106
50DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52201882
51E2F7_22180533_ChIP-Seq_HELA_Human1.52142871
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.51914481
53CREB1_26743006_Chip-Seq_LNCaP_Human1.50355243
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47641033
55MAF_26560356_Chip-Seq_TH1_Human1.46917534
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45882085
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45844935
58SMC4_20622854_ChIP-Seq_HELA_Human1.45611190
59TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.45552229
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45541477
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45007100
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43758714
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42527149
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.40535333
65SCL_19346495_ChIP-Seq_HPC-7_Human1.39288461
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38356630
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36006623
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35691768
69BCOR_27268052_Chip-Seq_Bcells_Human1.35430367
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34730777
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.34145887
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33113633
73PHF8_20622854_ChIP-Seq_HELA_Human1.32127677
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31997617
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.31605512
76CTCF_27219007_Chip-Seq_Bcells_Human1.30596550
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30317526
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29295558
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29263007
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29117697
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27944799
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27875373
83MAF_26560356_Chip-Seq_TH2_Human1.27193352
84TP53_22127205_ChIP-Seq_IMR90_Human1.27150048
85MYB_26560356_Chip-Seq_TH1_Human1.25485143
86BCL6_27268052_Chip-Seq_Bcells_Human1.25396847
87VDR_24763502_ChIP-Seq_THP-1_Human1.25310207
88CTCF_21964334_ChIP-Seq_BJAB-B_Human1.25302475
89* SPI1_23547873_ChIP-Seq_NB4_Human1.25165575
90E2F1_20622854_ChIP-Seq_HELA_Human1.24206804
91SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.24195751
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22949047
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22372568
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21663695
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20082372
96IRF8_27001747_Chip-Seq_BMDM_Mouse1.19793918
97PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19791307
98MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18380602
99SPI1_23127762_ChIP-Seq_K562_Human1.16325575
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16049380
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15670765
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15282943
103SA1_27219007_Chip-Seq_Bcells_Human1.13549764
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13453838
105MYB_26560356_Chip-Seq_TH2_Human1.13226973
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13175749
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12574596
108TP63_22573176_ChIP-Seq_HFKS_Human1.12409577
109OCT4_19829295_ChIP-Seq_ESCs_Human1.12328026
110TET1_21490601_ChIP-Seq_MESCs_Mouse1.12312942
111IRF8_21731497_ChIP-ChIP_J774_Mouse1.11590723
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11511611
113NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.10642802
114EGR1_19374776_ChIP-ChIP_THP-1_Human1.10600615
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10264513
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09238915
117FOXP1_21924763_ChIP-Seq_HESCs_Human1.08999122
118NCOR1_26117541_ChIP-Seq_K562_Human1.08457205
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08041165
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.07099296
121ESR2_21235772_ChIP-Seq_MCF-7_Human1.06809663
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06440955
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05965248
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05918585
125REST_18959480_ChIP-ChIP_MESCs_Mouse1.05677798
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05545583
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04849667
128GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04547813
129TP53_23651856_ChIP-Seq_MEFs_Mouse1.03435913
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03406157
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03154238
132GATA1_19941827_ChIP-Seq_MEL_Mouse1.02518356
133RUNX1_27514584_Chip-Seq_MCF-7_Human1.02165371
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01684183
135* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01454360
136GATA1_19941826_ChIP-Seq_K562_Human1.00405881
137RUNX_20019798_ChIP-Seq_JUKART_Human0.99655752
138SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99083334
139POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96738569
140ZNF263_19887448_ChIP-Seq_K562_Human0.95782648
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95655905
142EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95469154
143NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95414986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.71355764
2MP0003436_decreased_susceptibility_to3.79048681
3MP0003303_peritoneal_inflammation3.52381173
4MP0002653_abnormal_ependyma_morphology3.21876520
5MP0005451_abnormal_body_composition2.92842766
6MP0005058_abnormal_lysosome_morphology2.72251202
7MP0003283_abnormal_digestive_organ2.55505059
8MP0001835_abnormal_antigen_presentation2.55348987
9MP0008260_abnormal_autophagy2.48073844
10MP0003763_abnormal_thymus_physiology2.37142086
11MP0009278_abnormal_bone_marrow2.29490256
12MP0001800_abnormal_humoral_immune2.28793459
13MP0000685_abnormal_immune_system2.28636383
14MP0005000_abnormal_immune_tolerance2.27364037
15MP0003635_abnormal_synaptic_transmissio2.25785155
16MP0002419_abnormal_innate_immunity2.24014487
17MP0001790_abnormal_immune_system2.23175151
18MP0005387_immune_system_phenotype2.23175151
19MP0003300_gastrointestinal_ulcer2.21093542
20MP0005025_abnormal_response_to2.20120510
21MP0008961_abnormal_basal_metabolism2.07634071
22MP0003724_increased_susceptibility_to2.05308168
23MP0004947_skin_inflammation2.03563565
24MP0002723_abnormal_immune_serum1.99251913
25MP0004233_abnormal_muscle_weight1.98240213
26MP0002420_abnormal_adaptive_immunity1.95634639
27MP0001819_abnormal_immune_cell1.93711857
28MP0002452_abnormal_antigen_presenting1.93536712
29MP0005423_abnormal_somatic_nervous1.92882893
30MP0003787_abnormal_imprinting1.90006785
31MP0001849_ear_inflammation1.88406876
32MP0009333_abnormal_splenocyte_physiolog1.88207873
33MP0003172_abnormal_lysosome_physiology1.84894815
34MP0003191_abnormal_cellular_cholesterol1.82796907
35MP0008569_lethality_at_weaning1.81664220
36MP0009046_muscle_twitch1.81136466
37MP0002398_abnormal_bone_marrow1.79859496
38MP0005671_abnormal_response_to1.78985635
39MP0004510_myositis1.78436791
40MP0009840_abnormal_foam_cell1.76065744
41MP0004185_abnormal_adipocyte_glucose1.75762618
42MP0000569_abnormal_digit_pigmentation1.71830888
43MP0004885_abnormal_endolymph1.71252935
44MP0002064_seizures1.67765315
45MP0000716_abnormal_immune_system1.62796209
46MP0009785_altered_susceptibility_to1.62784351
47MP0001533_abnormal_skeleton_physiology1.59978007
48MP0000955_abnormal_spinal_cord1.57858619
49MP0002405_respiratory_system_inflammati1.56770777
50MP0005464_abnormal_platelet_physiology1.56215326
51MP0003111_abnormal_nucleus_morphology1.55520332
52MP0002822_catalepsy1.54943866
53MP0000858_altered_metastatic_potential1.52546239
54MP0010155_abnormal_intestine_physiology1.52130482
55MP0004858_abnormal_nervous_system1.50558650
56MP0002063_abnormal_learning/memory/cond1.50400649
57MP0005666_abnormal_adipose_tissue1.49487869
58MP0004811_abnormal_neuron_physiology1.48643125
59MP0010030_abnormal_orbit_morphology1.48338239
60MP0001873_stomach_inflammation1.47151164
61MP0002722_abnormal_immune_system1.46120782
62MP0003122_maternal_imprinting1.44188734
63MP0002429_abnormal_blood_cell1.40018365
64MP0003121_genomic_imprinting1.37405301
65MP0001853_heart_inflammation1.36893471
66MP0002148_abnormal_hypersensitivity_rea1.36524828
67MP0004133_heterotaxia1.36460540
68MP0001486_abnormal_startle_reflex1.36167822
69MP0003453_abnormal_keratinocyte_physiol1.36058685
70MP0000678_abnormal_parathyroid_gland1.35744535
71MP0003091_abnormal_cell_migration1.34507520
72MP0002089_abnormal_postnatal_growth/wei1.33761279
73MP0003123_paternal_imprinting1.32946726
74MP0000689_abnormal_spleen_morphology1.32945777
75MP0009745_abnormal_behavioral_response1.32906407
76MP0002998_abnormal_bone_remodeling1.32487787
77MP0005076_abnormal_cell_differentiation1.31782852
78MP0006082_CNS_inflammation1.31004205
79MP0004270_analgesia1.30361533
80MP0010352_gastrointestinal_tract_polyps1.26695524
81MP0008770_decreased_survivor_rate1.25702857
82MP0002272_abnormal_nervous_system1.24950019
83MP0002084_abnormal_developmental_patter1.24498615
84MP0002909_abnormal_adrenal_gland1.23144673
85MP0003329_amyloid_beta_deposits1.21261862
86MP0002572_abnormal_emotion/affect_behav1.20675249
87MP0005375_adipose_tissue_phenotype1.20347066
88MP0004142_abnormal_muscle_tone1.19288813
89MP0001845_abnormal_inflammatory_respons1.19110065
90MP0005310_abnormal_salivary_gland1.18735259
91MP0002396_abnormal_hematopoietic_system1.18685345
92MP0003880_abnormal_central_pattern1.15252210
93MP0000751_myopathy1.15144975
94MP0003861_abnormal_nervous_system1.14103740
95MP0004381_abnormal_hair_follicle1.13655814
96MP0002269_muscular_atrophy1.12453929
97MP0000003_abnormal_adipose_tissue1.12118290
98MP0003119_abnormal_digestive_system1.10653102
99MP0002152_abnormal_brain_morphology1.10069851
100MP0002085_abnormal_embryonic_tissue1.08660483
101MP0008057_abnormal_DNA_replication1.08126320
102MP0001851_eye_inflammation1.07646102
103MP0001348_abnormal_lacrimal_gland1.07432201
104MP0002933_joint_inflammation1.06363852
105MP0003828_pulmonary_edema1.05411260
106MP0000747_muscle_weakness1.04557047
107MP0003075_altered_response_to1.04466976
108MP0008469_abnormal_protein_level1.04321414
109MP0004197_abnormal_fetal_growth/weight/1.03006797
110MP0002132_abnormal_respiratory_system1.02956174
111MP0002882_abnormal_neuron_morphology1.02103750
112MP0001730_embryonic_growth_arrest1.02101857
113MP0003183_abnormal_peptide_metabolism1.01597591
114MP0000534_abnormal_ureter_morphology1.01353556
115MP0008877_abnormal_DNA_methylation1.00896660
116MP0003566_abnormal_cell_adhesion0.97996333
117MP0005623_abnormal_meninges_morphology0.97470894
118MP0003690_abnormal_glial_cell0.96785627
119MP0003705_abnormal_hypodermis_morpholog0.96153436
120MP0003656_abnormal_erythrocyte_physiolo0.95936712
121MP0003137_abnormal_impulse_conducting0.95916399
122MP0005409_darkened_coat_color0.95612577
123MP0005410_abnormal_fertilization0.95405309
124MP0000703_abnormal_thymus_morphology0.94442103
125MP0000733_abnormal_muscle_development0.93942730
126MP0001545_abnormal_hematopoietic_system0.93493431
127MP0005397_hematopoietic_system_phenotyp0.93493431
128MP0002249_abnormal_larynx_morphology0.92830270
129MP0004145_abnormal_muscle_electrophysio0.92017187
130MP0000778_abnormal_nervous_system0.91389194
131MP0000604_amyloidosis0.88690159
132MP0000350_abnormal_cell_proliferation0.88218940
133MP0005174_abnormal_tail_pigmentation0.87927281
134MP0005075_abnormal_melanosome_morpholog0.87030517
135MP0005499_abnormal_olfactory_system0.86084857
136MP0005394_taste/olfaction_phenotype0.86084857
137MP0002877_abnormal_melanocyte_morpholog0.85639477
138MP0005380_embryogenesis_phenotype0.85592016
139MP0001672_abnormal_embryogenesis/_devel0.85592016
140MP0005621_abnormal_cell_physiology0.84345725
141MP0002138_abnormal_hepatobiliary_system0.84252681
142MP0002080_prenatal_lethality0.84020800
143MP0000490_abnormal_crypts_of0.82890755
144MP0010769_abnormal_survival0.82501626
145MP0002066_abnormal_motor_capabilities/c0.82334231
146MP0000467_abnormal_esophagus_morphology0.81535469
147MP0004264_abnormal_extraembryonic_tissu0.81350068
148MP0001293_anophthalmia0.81308353
149MP0010768_mortality/aging0.81300633
150MP0010630_abnormal_cardiac_muscle0.80897932
151MP0005166_decreased_susceptibility_to0.80437879
152MP0000465_gastrointestinal_hemorrhage0.80418940
153MP0002086_abnormal_extraembryonic_tissu0.80236697
154MP0003077_abnormal_cell_cycle0.80221941
155MP0002067_abnormal_sensory_capabilities0.79708575
156MP0002166_altered_tumor_susceptibility0.78940316
157MP0002925_abnormal_cardiovascular_devel0.78802439
158MP0004087_abnormal_muscle_fiber0.78699259
159MP0003115_abnormal_respiratory_system0.78061345
160MP0000428_abnormal_craniofacial_morphol0.77883868
161MP0002234_abnormal_pharynx_morphology0.77868786
162MP0004808_abnormal_hematopoietic_stem0.77723260
163MP0003633_abnormal_nervous_system0.77661324
164MP0005390_skeleton_phenotype0.77377097
165MP0000759_abnormal_skeletal_muscle0.77370416
166MP0002184_abnormal_innervation0.77122939
167MP0003866_abnormal_defecation0.76877861
168MP0003634_abnormal_glial_cell0.76758014
169MP0002557_abnormal_social/conspecific_i0.75992268
170MP0001697_abnormal_embryo_size0.75635535
171MP0008874_decreased_physiological_sensi0.75257680
172MP0003984_embryonic_growth_retardation0.74687995
173MP0003279_aneurysm0.71307347
174MP0009931_abnormal_skin_appearance0.70133001
175MP0002009_preneoplasia0.68548544
176MP0003448_altered_tumor_morphology0.68143083
177MP0000249_abnormal_blood_vessel0.67716373
178MP0009115_abnormal_fat_cell0.67487169
179MP0001663_abnormal_digestive_system0.66744171
180MP0002970_abnormal_white_adipose0.64546188

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.17610573
2Hyperacusis (HP:0010780)4.07998321
3Abnormality of the lower motor neuron (HP:0002366)3.88022868
4Insomnia (HP:0100785)3.66655365
5Ependymoma (HP:0002888)3.36417189
6Neoplasm of the heart (HP:0100544)3.34470440
7Cellulitis (HP:0100658)3.27898736
8Colitis (HP:0002583)3.27393411
9Recurrent abscess formation (HP:0002722)3.24781196
10Recurrent bacterial skin infections (HP:0005406)3.23781765
11Increased IgE level (HP:0003212)3.18543729
12Annular pancreas (HP:0001734)3.09928627
13Abnormality of macrophages (HP:0004311)3.07290028
14Obstructive sleep apnea (HP:0002870)3.06938021
15Supranuclear gaze palsy (HP:0000605)3.01552143
16Pointed chin (HP:0000307)2.98136452
17Astrocytoma (HP:0009592)2.97888627
18Abnormality of the astrocytes (HP:0100707)2.97888627
19Overriding aorta (HP:0002623)2.96879443
20Renal duplication (HP:0000075)2.93155532
21Gastrointestinal inflammation (HP:0004386)2.92129466
22Upper limb amyotrophy (HP:0009129)2.87539206
23Distal upper limb amyotrophy (HP:0007149)2.87539206
24Myokymia (HP:0002411)2.86889536
25Myositis (HP:0100614)2.82713985
26Elfin facies (HP:0004428)2.81796606
27Chronic obstructive pulmonary disease (HP:0006510)2.81195336
28Obstructive lung disease (HP:0006536)2.81195336
29Mediastinal lymphadenopathy (HP:0100721)2.80866394
30Meningitis (HP:0001287)2.79053913
31Broad face (HP:0000283)2.73207322
32Cerebral aneurysm (HP:0004944)2.68899184
33Recurrent gram-negative bacterial infections (HP:0005420)2.67236901
34Hemiplegia (HP:0002301)2.66376116
35Inflammation of the large intestine (HP:0002037)2.61577261
36Macroorchidism (HP:0000053)2.59790930
37Neoplasm of the oral cavity (HP:0100649)2.59751263
38Recurrent fungal infections (HP:0002841)2.59199078
39Ankle clonus (HP:0011448)2.58942374
40Agammaglobulinemia (HP:0004432)2.58372894
41Recurrent viral infections (HP:0004429)2.55486571
42Gastrointestinal infarctions (HP:0005244)2.50895220
43Orchitis (HP:0100796)2.46132503
44Gastrointestinal stroma tumor (HP:0100723)2.41871822
45Renovascular hypertension (HP:0100817)2.41546223
46Gingivitis (HP:0000230)2.41483007
47Hand muscle atrophy (HP:0009130)2.36012166
48Increased nuchal translucency (HP:0010880)2.31998938
49Distal lower limb amyotrophy (HP:0008944)2.30351081
50Hemorrhage of the eye (HP:0011885)2.30207252
51Dysostosis multiplex (HP:0000943)2.29241730
52Panhypogammaglobulinemia (HP:0003139)2.29193108
53Prolonged bleeding time (HP:0003010)2.26175716
54Metaphyseal cupping (HP:0003021)2.24500100
55Heterotopia (HP:0002282)2.24135279
56Recurrent skin infections (HP:0001581)2.23894285
57Basal cell carcinoma (HP:0002671)2.23620655
58Abnormal delayed hypersensitivity skin test (HP:0002963)2.21363961
59Pustule (HP:0200039)2.20393626
60Emphysema (HP:0002097)2.19940883
61Focal seizures (HP:0007359)2.18591514
62Turricephaly (HP:0000262)2.17922224
63Rib fusion (HP:0000902)2.17415598
64Flat cornea (HP:0007720)2.17237214
65Segmental peripheral demyelination/remyelination (HP:0003481)2.17189141
66Polygenic inheritance (HP:0010982)2.17144526
67Ulnar bowing (HP:0003031)2.16783519
68Systemic lupus erythematosus (HP:0002725)2.15871359
69Thin bony cortex (HP:0002753)2.15524858
70Elevated erythrocyte sedimentation rate (HP:0003565)2.15366945
71Trigonocephaly (HP:0000243)2.13901290
72Vasculitis (HP:0002633)2.13072697
73Slow saccadic eye movements (HP:0000514)2.10817568
74Centrally nucleated skeletal muscle fibers (HP:0003687)2.09370961
75Visual hallucinations (HP:0002367)2.08885553
76Increased cerebral lipofuscin (HP:0011813)2.07954499
77Hemiparesis (HP:0001269)2.07765667
78Retrobulbar optic neuritis (HP:0100654)2.06124546
79Optic neuritis (HP:0100653)2.06124546
80Abnormality of the thoracic spine (HP:0100711)2.06087881
81Increased connective tissue (HP:0009025)2.05519200
82Chronic mucocutaneous candidiasis (HP:0002728)2.04984427
83Recurrent cutaneous fungal infections (HP:0011370)2.04984427
84Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03545879
85Short 4th metacarpal (HP:0010044)2.03545879
86Urinary urgency (HP:0000012)2.03453781
87Hypertensive crisis (HP:0100735)2.03166351
88Supernumerary ribs (HP:0005815)2.01709550
89Increased serum ferritin (HP:0003281)2.01466418
90Difficulty running (HP:0009046)2.00690057
91Glioma (HP:0009733)1.99391813
92Broad palm (HP:0001169)1.99265582
93Thoracic kyphosis (HP:0002942)1.99086154
94Skin tags (HP:0010609)1.98422000
95Easy fatigability (HP:0003388)1.97751517
96Bowel diverticulosis (HP:0005222)1.96837135
97Ankyloglossia (HP:0010296)1.96759037
98Purpura (HP:0000979)1.95950272
99Spastic gait (HP:0002064)1.94612944
100Abnormality of oral frenula (HP:0000190)1.94020430
101Deep venous thrombosis (HP:0002625)1.93875686
102Obsessive-compulsive behavior (HP:0000722)1.92592788
103Epistaxis (HP:0000421)1.91661159
104Disproportionate tall stature (HP:0001519)1.91240206
105Depression (HP:0000716)1.90983477
106Spontaneous hematomas (HP:0007420)1.90688530
107Chest pain (HP:0100749)1.90451739
108Anteriorly placed anus (HP:0001545)1.90379278
109Impaired social interactions (HP:0000735)1.90245641
110Abnormal social behavior (HP:0012433)1.90245641
111Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90009232
112Papilloma (HP:0012740)1.89410701
113Verrucae (HP:0200043)1.89410701
114Impaired smooth pursuit (HP:0007772)1.88970709
115Vertebral arch anomaly (HP:0008438)1.88324726
116Postural instability (HP:0002172)1.87860903
117Viral hepatitis (HP:0006562)1.87053971
118Amyloidosis (HP:0011034)1.86702845
119Broad metatarsal (HP:0001783)1.85682088
120Neoplasm of striated muscle (HP:0009728)1.85198334
121Encephalitis (HP:0002383)1.84697830
122Shallow orbits (HP:0000586)1.84326095
123Genetic anticipation (HP:0003743)1.84318505
124Abnormality of the peritoneum (HP:0002585)1.84283274
125Osteomyelitis (HP:0002754)1.83746150
126Supernumerary bones of the axial skeleton (HP:0009144)1.83197414
127Hypertriglyceridemia (HP:0002155)1.82844633
128Loss of speech (HP:0002371)1.82765152
129Seborrheic dermatitis (HP:0001051)1.82516609
130Amyotrophic lateral sclerosis (HP:0007354)1.81690732
131Urethral obstruction (HP:0000796)1.81669054
132Fatigue (HP:0012378)1.80332162
133Generalized hypotonia (HP:0001290)1.80313411
134Megalocornea (HP:0000485)1.79114278
135Dysmetria (HP:0001310)1.78993441
136Restrictive lung disease (HP:0002091)1.77859617
137Abnormality of the salivary glands (HP:0010286)1.77334246
138Stridor (HP:0010307)1.77186530
139Achilles tendon contracture (HP:0001771)1.76453635
140Increased neuronal autofluorescent lipopigment (HP:0002074)1.74452058
141Abnormality of the fingertips (HP:0001211)1.74123364
142J-shaped sella turcica (HP:0002680)1.73693753
143Congenital hip dislocation (HP:0001374)1.73690735
144Long palpebral fissure (HP:0000637)1.73075749
145Flat acetabular roof (HP:0003180)1.73047908
146Deep palmar crease (HP:0006191)1.72982065
147Bladder diverticulum (HP:0000015)1.72922392
148Abnormality of the diencephalon (HP:0010662)1.72838440
149Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71097395
150Malnutrition (HP:0004395)1.70833597
151Peripheral hypomyelination (HP:0007182)1.70175759
152Arnold-Chiari malformation (HP:0002308)1.70060440
153Onion bulb formation (HP:0003383)1.69693938
154Lower limb amyotrophy (HP:0007210)1.69517636
155Lymphopenia (HP:0001888)1.69264277
156Rapidly progressive (HP:0003678)1.69247626
157Abnormality of ocular smooth pursuit (HP:0000617)1.69111907
158Broad thumb (HP:0011304)1.69106719
159Depressed nasal tip (HP:0000437)1.68674451
160Aqueductal stenosis (HP:0002410)1.67368391
161Abnormality of complement system (HP:0005339)1.67241869
162Urticaria (HP:0001025)1.67221938
163Preauricular skin tag (HP:0000384)1.66954847
164Pseudobulbar signs (HP:0002200)1.66697382
165Abnormality of mucopolysaccharide metabolism (HP:0011020)1.66438010
166Abnormality of polysaccharide metabolism (HP:0011012)1.66438010
167Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66438010
168Axonal loss (HP:0003447)1.66413782
169Sacral dimple (HP:0000960)1.66264500
170EMG: neuropathic changes (HP:0003445)1.65600308
171Anal stenosis (HP:0002025)1.65516467
172Intention tremor (HP:0002080)1.65092142
173Vertebral fusion (HP:0002948)1.64531927
174Attention deficit hyperactivity disorder (HP:0007018)1.64202471
175Asymmetric septal hypertrophy (HP:0001670)1.64137561
176Tented upper lip vermilion (HP:0010804)1.63988650
177Mucopolysacchariduria (HP:0008155)1.63814899
178Urinary glycosaminoglycan excretion (HP:0003541)1.63814899
179Bowed forearm bones (HP:0003956)1.63513881
180Bowing of the arm (HP:0006488)1.63513881
181Abnormality of the 4th metacarpal (HP:0010012)1.61690556
182Poor eye contact (HP:0000817)1.61099518
183Neuronal loss in central nervous system (HP:0002529)1.59910787
184Selective tooth agenesis (HP:0001592)1.59832162
185Urinary bladder sphincter dysfunction (HP:0002839)1.59640818
186Poikiloderma (HP:0001029)1.58596751
187Esophageal atresia (HP:0002032)1.57803847
188Bundle branch block (HP:0011710)1.56077848
189Acute lymphatic leukemia (HP:0006721)1.54584936
190Dysmetric saccades (HP:0000641)1.53009364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.22343879
2MAP3K103.16173252
3TYRO32.92816326
4EEF2K2.60576649
5TRIB32.49598489
6CDK122.48155834
7SMG12.46883945
8SIK22.46457581
9UHMK12.16052078
10MAP2K32.06231113
11MAP3K92.01146073
12PRKD31.96749992
13IRAK31.80836965
14PAK61.80608510
15TYK21.78496818
16IRAK41.66137690
17PDGFRA1.64988554
18ALK1.60523506
19PKN21.59617890
20ERN11.58923626
21BLK1.58227008
22SIK31.55509092
23MARK21.51712045
24MAP4K11.47386790
25MAP3K141.46302149
26NTRK21.43784387
27NME21.40426085
28CAMK1G1.40357628
29RIPK11.40314818
30DDR21.36767597
31TBK11.34738297
32STK381.34485497
33TAOK11.30856492
34ZAP701.27548249
35PRKD21.24427763
36NTRK31.24216931
37MAP3K71.23487367
38NEK21.22057411
39GRK61.21470386
40DYRK1B1.21111814
41MTOR1.19125646
42TAOK21.18688270
43TESK21.16943164
44DAPK11.12397595
45BTK1.12227096
46MAP3K11.09122390
47EPHA41.09047167
48JAK31.08778552
49DAPK21.07591053
50BMX1.06445586
51WNK11.06248348
52TNK21.05598906
53CDC42BPA1.04212747
54DMPK1.03079912
55MAP3K31.02306690
56TTN1.01405406
57BRD41.00982324
58IRAK20.93093769
59CAMK1D0.93070888
60PRKCH0.92830165
61EPHB10.92190126
62CDK190.91864701
63FES0.91786145
64PDPK10.90770541
65MAPKAPK30.90180318
66RPS6KB20.88989773
67SIK10.88061831
68MAPK150.85514242
69CAMKK10.85027554
70HIPK20.83719692
71PTK60.83135531
72MATK0.82853733
73SCYL20.82383089
74MAPK120.81784972
75KSR20.81643571
76SYK0.81558553
77IKBKE0.81020367
78CAMK10.79673220
79NTRK10.79278947
80PAK20.78696060
81PHKG10.76284348
82PHKG20.76284348
83RPS6KL10.76213436
84RPS6KC10.76213436
85PAK40.74415520
86PNCK0.71692218
87MARK30.68327279
88CDK50.67916448
89MAP3K60.67063735
90IKBKB0.66932607
91JAK10.66694541
92PRKD10.64441866
93MAPK110.64373738
94AKT20.63434677
95FGFR20.62947561
96RPS6KA20.62830915
97PRPF4B0.62524446
98CLK10.61978230
99STK110.61962341
100PDGFRB0.61707404
101MAP3K40.61470276
102MAP3K130.61379278
103KIT0.61051092
104FGFR30.60484485
105MAP2K20.60297437
106FGFR40.60057064
107JAK20.59536884
108MAPK100.59406107
109RIPK40.58800079
110ITK0.58534668
111CAMK40.58324037
112CSF1R0.56326653
113RPS6KA60.56070378
114CDK20.55984814
115CDK40.55784447
116LYN0.55271892
117LCK0.55023641
118MAP3K110.54851114
119LRRK20.54626463
120CDK150.50927423
121MAPK80.50588512
122HCK0.50284249
123CDK11A0.49958104
124ARAF0.49836385
125CHEK10.46937297
126MARK10.46805791
127MINK10.46120956
128PDK10.45829984
129GSK3B0.45296545
130CDK70.44758209
131RET0.44526483
132CSK0.44485306
133MAPK90.44025955
134CDK180.43586803
135MAP3K80.43354777
136CHUK0.43352388
137CDK60.42316194
138MAPK70.41892989
139SGK30.40991354
140PTK20.39583185
141CDK90.39349045
142TESK10.37907641
143MAP2K60.37587039
144FGR0.37571298
145RPS6KA10.37432785
146IRAK10.35260117
147MAPK40.35137086
148MAPKAPK20.34601905

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.80831076
2Osteoclast differentiation_Homo sapiens_hsa043802.21099776
3Leishmaniasis_Homo sapiens_hsa051402.11621028
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90086163
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83226672
6Notch signaling pathway_Homo sapiens_hsa043301.80499600
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66542483
8Staphylococcus aureus infection_Homo sapiens_hsa051501.65656087
9Olfactory transduction_Homo sapiens_hsa047401.58503436
10mTOR signaling pathway_Homo sapiens_hsa041501.57521642
11Glutamatergic synapse_Homo sapiens_hsa047241.53420561
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.52921377
13Circadian entrainment_Homo sapiens_hsa047131.49578993
14Long-term potentiation_Homo sapiens_hsa047201.46351379
15VEGF signaling pathway_Homo sapiens_hsa043701.45849334
16Tuberculosis_Homo sapiens_hsa051521.45746366
17mRNA surveillance pathway_Homo sapiens_hsa030151.45565093
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45408836
19Influenza A_Homo sapiens_hsa051641.44572034
20Allograft rejection_Homo sapiens_hsa053301.44323859
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42508792
22Toxoplasmosis_Homo sapiens_hsa051451.41311612
23GABAergic synapse_Homo sapiens_hsa047271.40996496
24Synaptic vesicle cycle_Homo sapiens_hsa047211.38181341
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37798131
26Morphine addiction_Homo sapiens_hsa050321.37099662
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36334210
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32435329
29Herpes simplex infection_Homo sapiens_hsa051681.31761075
30Type II diabetes mellitus_Homo sapiens_hsa049301.31624518
31Thyroid hormone signaling pathway_Homo sapiens_hsa049191.29944782
32Graft-versus-host disease_Homo sapiens_hsa053321.28271576
33TNF signaling pathway_Homo sapiens_hsa046681.28069665
34Autoimmune thyroid disease_Homo sapiens_hsa053201.27591803
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27534029
36Oxytocin signaling pathway_Homo sapiens_hsa049211.25729974
37GnRH signaling pathway_Homo sapiens_hsa049121.25611925
38Gastric acid secretion_Homo sapiens_hsa049711.25169123
39B cell receptor signaling pathway_Homo sapiens_hsa046621.24471268
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24255017
41Hepatitis B_Homo sapiens_hsa051611.22507646
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.21935868
43Nicotine addiction_Homo sapiens_hsa050331.20606645
44Chronic myeloid leukemia_Homo sapiens_hsa052201.20601549
45Dopaminergic synapse_Homo sapiens_hsa047281.20477615
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20423604
47Phospholipase D signaling pathway_Homo sapiens_hsa040721.20297095
48Insulin secretion_Homo sapiens_hsa049111.18396863
49Non-small cell lung cancer_Homo sapiens_hsa052231.17137733
50Measles_Homo sapiens_hsa051621.16318872
51Basal cell carcinoma_Homo sapiens_hsa052171.16055392
52Lysine degradation_Homo sapiens_hsa003101.15459862
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15391998
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15030068
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14614718
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13192745
57Amphetamine addiction_Homo sapiens_hsa050311.11902997
58ErbB signaling pathway_Homo sapiens_hsa040121.11685050
59Glioma_Homo sapiens_hsa052141.11625935
60Salivary secretion_Homo sapiens_hsa049701.10786116
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10325540
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09845684
63Glycosaminoglycan degradation_Homo sapiens_hsa005311.08982402
64Spliceosome_Homo sapiens_hsa030401.08942844
65Estrogen signaling pathway_Homo sapiens_hsa049151.08938622
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08771370
67Hepatitis C_Homo sapiens_hsa051601.08442450
68NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07622961
69Cholinergic synapse_Homo sapiens_hsa047251.07406910
70Viral myocarditis_Homo sapiens_hsa054161.07352429
71Primary immunodeficiency_Homo sapiens_hsa053401.06397241
72Intestinal immune network for IgA production_Homo sapiens_hsa046721.05020055
73Central carbon metabolism in cancer_Homo sapiens_hsa052301.04752271
74Hedgehog signaling pathway_Homo sapiens_hsa043401.04534011
75Choline metabolism in cancer_Homo sapiens_hsa052311.04156425
76Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03886592
77Chemokine signaling pathway_Homo sapiens_hsa040621.03609542
78Gap junction_Homo sapiens_hsa045401.02491204
79Acute myeloid leukemia_Homo sapiens_hsa052211.02009071
80Prion diseases_Homo sapiens_hsa050201.01265982
81MAPK signaling pathway_Homo sapiens_hsa040101.00873677
82Colorectal cancer_Homo sapiens_hsa052101.00160668
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.98241342
84Apoptosis_Homo sapiens_hsa042100.97513329
85Antigen processing and presentation_Homo sapiens_hsa046120.96972481
86Dorso-ventral axis formation_Homo sapiens_hsa043200.96949995
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96182500
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96093162
89Malaria_Homo sapiens_hsa051440.95714481
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95059278
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.94721721
92Oocyte meiosis_Homo sapiens_hsa041140.94429988
93Axon guidance_Homo sapiens_hsa043600.93872081
94Prolactin signaling pathway_Homo sapiens_hsa049170.92474738
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91956070
96Cocaine addiction_Homo sapiens_hsa050300.90671654
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.90102664
98Pertussis_Homo sapiens_hsa051330.89964949
99T cell receptor signaling pathway_Homo sapiens_hsa046600.89253537
100Endocytosis_Homo sapiens_hsa041440.88757485
101Calcium signaling pathway_Homo sapiens_hsa040200.88671613
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88468124
103cAMP signaling pathway_Homo sapiens_hsa040240.88073197
104Base excision repair_Homo sapiens_hsa034100.87771693
105Wnt signaling pathway_Homo sapiens_hsa043100.85533018
106Endometrial cancer_Homo sapiens_hsa052130.85234610
107Epstein-Barr virus infection_Homo sapiens_hsa051690.85056436
108Long-term depression_Homo sapiens_hsa047300.85041158
109Asthma_Homo sapiens_hsa053100.84535442
110Rap1 signaling pathway_Homo sapiens_hsa040150.84338541
111Hematopoietic cell lineage_Homo sapiens_hsa046400.84148142
112Proteoglycans in cancer_Homo sapiens_hsa052050.83794542
113Renal cell carcinoma_Homo sapiens_hsa052110.82159984
114Type I diabetes mellitus_Homo sapiens_hsa049400.81694118
115MicroRNAs in cancer_Homo sapiens_hsa052060.81588822
116Viral carcinogenesis_Homo sapiens_hsa052030.81231782
117Hippo signaling pathway_Homo sapiens_hsa043900.80645037
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80166095
119Inositol phosphate metabolism_Homo sapiens_hsa005620.79292084
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79070564
121Dilated cardiomyopathy_Homo sapiens_hsa054140.78874764
122Insulin resistance_Homo sapiens_hsa049310.77713611
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77422097
124Bladder cancer_Homo sapiens_hsa052190.77420423
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77266926
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77045815
127Fatty acid biosynthesis_Homo sapiens_hsa000610.76786983
128Lysosome_Homo sapiens_hsa041420.76575868
129Salmonella infection_Homo sapiens_hsa051320.75509036
130Fructose and mannose metabolism_Homo sapiens_hsa000510.74431468
131DNA replication_Homo sapiens_hsa030300.73719349
132Renin secretion_Homo sapiens_hsa049240.72607974
133Amoebiasis_Homo sapiens_hsa051460.72506840
134Melanogenesis_Homo sapiens_hsa049160.72417740
135Legionellosis_Homo sapiens_hsa051340.72050924
136African trypanosomiasis_Homo sapiens_hsa051430.70239445
137Prostate cancer_Homo sapiens_hsa052150.69917850
138Mismatch repair_Homo sapiens_hsa034300.69573056
139HIF-1 signaling pathway_Homo sapiens_hsa040660.69310767
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69088915
141Taste transduction_Homo sapiens_hsa047420.68929430
142Insulin signaling pathway_Homo sapiens_hsa049100.68723621
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67642234
144HTLV-I infection_Homo sapiens_hsa051660.67151188
145FoxO signaling pathway_Homo sapiens_hsa040680.65992649
146Shigellosis_Homo sapiens_hsa051310.65367058
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65359552
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64043093
149Platelet activation_Homo sapiens_hsa046110.64011844
150AMPK signaling pathway_Homo sapiens_hsa041520.63413261
151Thyroid cancer_Homo sapiens_hsa052160.63010925
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.62784363
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61605265
154Pancreatic cancer_Homo sapiens_hsa052120.60807157
155Pathways in cancer_Homo sapiens_hsa052000.59390897
156Pentose phosphate pathway_Homo sapiens_hsa000300.55205541

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