CKS1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.25428892
2CENP-A containing nucleosome assembly (GO:0034080)4.89533885
3DNA strand elongation involved in DNA replication (GO:0006271)4.84039673
4telomere maintenance via semi-conservative replication (GO:0032201)4.78736822
5ribosomal small subunit assembly (GO:0000028)4.75553258
6mitotic metaphase plate congression (GO:0007080)4.73740354
7chromatin remodeling at centromere (GO:0031055)4.71336212
8kinetochore organization (GO:0051383)4.70634464
9DNA deamination (GO:0045006)4.61668521
10protein localization to kinetochore (GO:0034501)4.60983981
11DNA strand elongation (GO:0022616)4.60929971
12kinetochore assembly (GO:0051382)4.52613086
13DNA replication initiation (GO:0006270)4.39637623
14ATP synthesis coupled proton transport (GO:0015986)4.38828759
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38828759
16DNA replication checkpoint (GO:0000076)4.33733505
17telomere maintenance via recombination (GO:0000722)4.33661449
18DNA replication-independent nucleosome assembly (GO:0006336)4.29134294
19DNA replication-independent nucleosome organization (GO:0034724)4.29134294
20chaperone-mediated protein transport (GO:0072321)4.17201268
21metaphase plate congression (GO:0051310)4.16468956
22protein localization to chromosome, centromeric region (GO:0071459)4.14355509
23maturation of SSU-rRNA (GO:0030490)4.12295492
24viral transcription (GO:0019083)4.12068170
25mitotic recombination (GO:0006312)4.09968238
26translational termination (GO:0006415)4.05493407
27attachment of spindle microtubules to kinetochore (GO:0008608)3.98730068
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.98552368
29ribosomal small subunit biogenesis (GO:0042274)3.94828748
30histone exchange (GO:0043486)3.92653622
31establishment of chromosome localization (GO:0051303)3.92467025
32DNA unwinding involved in DNA replication (GO:0006268)3.85398071
33formation of translation preinitiation complex (GO:0001731)3.84356368
34telomere maintenance via telomere lengthening (GO:0010833)3.84332879
35DNA ligation (GO:0006266)3.83457770
36nucleobase biosynthetic process (GO:0046112)3.77922073
37mitotic nuclear envelope disassembly (GO:0007077)3.77574774
38establishment of viral latency (GO:0019043)3.75576159
39mitotic sister chromatid segregation (GO:0000070)3.72587609
40translational elongation (GO:0006414)3.71347302
41proteasome assembly (GO:0043248)3.69578024
42DNA replication-dependent nucleosome assembly (GO:0006335)3.65757026
43DNA replication-dependent nucleosome organization (GO:0034723)3.65757026
44nucleotide-excision repair, DNA gap filling (GO:0006297)3.65622120
45deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.64097241
46regulation of spindle organization (GO:0090224)3.62639887
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.62620086
48ribosomal large subunit biogenesis (GO:0042273)3.61300175
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.60973709
50purine nucleobase biosynthetic process (GO:0009113)3.60675406
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.58933307
52mitotic chromosome condensation (GO:0007076)3.57875367
53translational initiation (GO:0006413)3.57196064
54regulation of mitotic spindle organization (GO:0060236)3.54738129
55spliceosomal snRNP assembly (GO:0000387)3.53605413
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.53149043
57cotranslational protein targeting to membrane (GO:0006613)3.52839989
58ribonucleoprotein complex biogenesis (GO:0022613)3.51238732
59regulation of mitochondrial translation (GO:0070129)3.51232853
60protein targeting to ER (GO:0045047)3.49711733
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49589364
62nuclear envelope disassembly (GO:0051081)3.45810282
63membrane disassembly (GO:0030397)3.45810282
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.44038052
65establishment of integrated proviral latency (GO:0075713)3.43086843
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.41948604
67spindle checkpoint (GO:0031577)3.41121056
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41106242
69respiratory electron transport chain (GO:0022904)3.40108174
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.37896688
71ribosome assembly (GO:0042255)3.35655245
72ribosome biogenesis (GO:0042254)3.35401513
73transcription-coupled nucleotide-excision repair (GO:0006283)3.35025627
74regulation of sister chromatid segregation (GO:0033045)3.33237098
75regulation of mitotic sister chromatid separation (GO:0010965)3.33237098
76regulation of mitotic sister chromatid segregation (GO:0033047)3.33237098
77establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30425475
78electron transport chain (GO:0022900)3.30345494
79sister chromatid segregation (GO:0000819)3.29704847
80protein localization to endoplasmic reticulum (GO:0070972)3.29315760
81positive regulation of ligase activity (GO:0051351)3.27017303
82negative regulation of mitotic sister chromatid separation (GO:2000816)3.26833431
83negative regulation of mitotic sister chromatid segregation (GO:0033048)3.26833431
84negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.26833431
85negative regulation of sister chromatid segregation (GO:0033046)3.26833431
86meiotic chromosome segregation (GO:0045132)3.26806641
87regulation of ubiquitin-protein transferase activity (GO:0051438)3.26325448
88regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.26089158
89rRNA processing (GO:0006364)3.25893507
90rRNA modification (GO:0000154)3.25767257
91negative regulation of chromosome segregation (GO:0051985)3.25494565
92negative regulation of ligase activity (GO:0051352)3.23190655
93negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23190655
94cellular protein complex disassembly (GO:0043624)3.22038631
95spindle assembly checkpoint (GO:0071173)3.21871714
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20149924
97viral life cycle (GO:0019058)3.19970471
98regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19606857
99regulation of mitotic spindle checkpoint (GO:1903504)3.19606857
100deoxyribonucleotide biosynthetic process (GO:0009263)3.18948094
101regulation of cellular amino acid metabolic process (GO:0006521)3.17974144
102folic acid-containing compound biosynthetic process (GO:0009396)3.17758263
103mitotic spindle assembly checkpoint (GO:0007094)3.16938833
104positive regulation of chromosome segregation (GO:0051984)3.16556145
105spliceosomal complex assembly (GO:0000245)3.15690887
106signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15404962
107signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15404962
108signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15404962
109termination of RNA polymerase III transcription (GO:0006386)3.14801257
110transcription elongation from RNA polymerase III promoter (GO:0006385)3.14801257
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14394587
112regulation of ligase activity (GO:0051340)3.14356919
113rRNA metabolic process (GO:0016072)3.13651830
114IMP biosynthetic process (GO:0006188)3.11076313
115* G1/S transition of mitotic cell cycle (GO:0000082)3.10871703
116* cell cycle G1/S phase transition (GO:0044843)3.10871703
117pseudouridine synthesis (GO:0001522)3.10098064
118mitotic spindle checkpoint (GO:0071174)3.09884861
119regulation of chromosome segregation (GO:0051983)3.09514548
120regulation of double-strand break repair via homologous recombination (GO:0010569)3.08554125
121translation (GO:0006412)3.08303574
122chromatin assembly or disassembly (GO:0006333)3.07438740
123chromosome segregation (GO:0007059)3.06821277
124regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06203685
125viral mRNA export from host cell nucleus (GO:0046784)3.04924055
126regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01508015
127nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00591366
128ATP-dependent chromatin remodeling (GO:0043044)3.00052149

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.06211978
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.74445370
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.41695083
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.88219289
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85148449
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.60386940
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.58720266
8* EST1_17652178_ChIP-ChIP_JURKAT_Human3.21945831
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.18847069
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.01878852
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97955096
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95845091
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.94268459
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88909880
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81822497
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60306141
17XRN2_22483619_ChIP-Seq_HELA_Human2.46476951
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.45093654
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42032421
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35800095
21AR_21909140_ChIP-Seq_LNCAP_Human2.32893438
22* VDR_23849224_ChIP-Seq_CD4+_Human2.28756832
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21534304
24DCP1A_22483619_ChIP-Seq_HELA_Human2.15788537
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15188023
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12961723
27* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03319246
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.03254220
29FOXP3_21729870_ChIP-Seq_TREG_Human2.02065733
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00305805
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.98587152
32GABP_19822575_ChIP-Seq_HepG2_Human1.93327991
33* TTF2_22483619_ChIP-Seq_HELA_Human1.91306643
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82589637
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82525421
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80397242
37* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79252949
38* ELK1_19687146_ChIP-ChIP_HELA_Human1.75517338
39* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70465535
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66466763
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65627908
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65473057
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58978454
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.58484560
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57624290
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57453668
47* SRF_21415370_ChIP-Seq_HL-1_Mouse1.56174694
48* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54808269
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54806110
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52762762
51CIITA_25753668_ChIP-Seq_RAJI_Human1.50636922
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43847015
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.42410438
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41562275
55* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35662685
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33146849
57* KDM5A_27292631_Chip-Seq_BREAST_Human1.31666962
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28051287
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26452090
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25223599
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.21599831
62* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19504966
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17232698
64MYC_22102868_ChIP-Seq_BL_Human1.17081838
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16614861
66* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14742610
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13772187
68MYC_18940864_ChIP-ChIP_HL60_Human1.13707032
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.13197634
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12487318
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12162491
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09766150
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09080284
74* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08565466
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07249144
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06603260
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.04352139
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04319793
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04236181
80TFEB_21752829_ChIP-Seq_HELA_Human1.03182010
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02038355
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01427558
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.00598413
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00261772
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00022400
86* SOX17_20123909_ChIP-Seq_XEN_Mouse0.98306205
87TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96892510
88* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94696234
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.94135187
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93697404
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92693243
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91866566
93* SPI1_23547873_ChIP-Seq_NB4_Human0.90510908
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88984835
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88665001
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85115842
97* VDR_21846776_ChIP-Seq_THP-1_Human0.84003151
98POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83544026
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83099117
100* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82703415
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82652783
102* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81799592
103SALL1_21062744_ChIP-ChIP_HESCs_Human0.79989187
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76253426
105SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74929765
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.74788059
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74611262
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73536338
109EWS_26573619_Chip-Seq_HEK293_Human0.73287222
110* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.73268448
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72766232
112* NANOG_21062744_ChIP-ChIP_HESCs_Human0.72051374
113* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71753077
114* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71694598
115* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70914532
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.70162699
117KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.69884091
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.69884091
119KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.69884091
120IRF1_19129219_ChIP-ChIP_H3396_Human0.67913665
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.67817822
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.65293114
123TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.64304261

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.18332004
2MP0003111_abnormal_nucleus_morphology4.78932718
3MP0004957_abnormal_blastocyst_morpholog4.76793554
4MP0010094_abnormal_chromosome_stability4.65694278
5MP0003077_abnormal_cell_cycle4.35617230
6MP0008057_abnormal_DNA_replication3.54901661
7MP0008058_abnormal_DNA_repair3.33810003
8MP0008932_abnormal_embryonic_tissue2.93250832
9* MP0008007_abnormal_cellular_replicative2.61015691
10MP0003123_paternal_imprinting2.42420573
11MP0002396_abnormal_hematopoietic_system2.33973810
12MP0001730_embryonic_growth_arrest2.19746552
13MP0000350_abnormal_cell_proliferation2.15513384
14MP0003786_premature_aging1.96535650
15MP0003718_maternal_effect1.96076350
16MP0000490_abnormal_crypts_of1.72752901
17MP0008877_abnormal_DNA_methylation1.72686059
18MP0001697_abnormal_embryo_size1.71727620
19MP0010030_abnormal_orbit_morphology1.69760276
20MP0003136_yellow_coat_color1.66096659
21MP0001672_abnormal_embryogenesis/_devel1.62074775
22MP0005380_embryogenesis_phenotype1.62074775
23MP0008789_abnormal_olfactory_epithelium1.59474890
24MP0002080_prenatal_lethality1.53337948
25MP0010352_gastrointestinal_tract_polyps1.53307725
26MP0000313_abnormal_cell_death1.51160944
27MP0010307_abnormal_tumor_latency1.48170383
28MP0002085_abnormal_embryonic_tissue1.47194240
29MP0004808_abnormal_hematopoietic_stem1.45257329
30MP0003984_embryonic_growth_retardation1.44320321
31* MP0002019_abnormal_tumor_incidence1.41818995
32MP0009333_abnormal_splenocyte_physiolog1.40786805
33MP0002088_abnormal_embryonic_growth/wei1.39888478
34MP0003186_abnormal_redox_activity1.39350364
35MP0003315_abnormal_perineum_morphology1.36145514
36MP0009379_abnormal_foot_pigmentation1.35895772
37MP0006054_spinal_hemorrhage1.31079531
38MP0001529_abnormal_vocalization1.30071583
39MP0005397_hematopoietic_system_phenotyp1.26730000
40MP0001545_abnormal_hematopoietic_system1.26730000
41MP0002102_abnormal_ear_morphology1.24487849
42MP0003806_abnormal_nucleotide_metabolis1.24394863
43MP0002086_abnormal_extraembryonic_tissu1.24269949
44MP0003567_abnormal_fetal_cardiomyocyte1.24264946
45MP0002084_abnormal_developmental_patter1.21603577
46MP0002697_abnormal_eye_size1.21328108
47MP0006292_abnormal_olfactory_placode1.18381900
48MP0002210_abnormal_sex_determination1.14134514
49MP0005499_abnormal_olfactory_system1.12611008
50MP0005394_taste/olfaction_phenotype1.12611008
51MP0003121_genomic_imprinting1.09836669
52MP0000372_irregular_coat_pigmentation1.09205896
53MP0004197_abnormal_fetal_growth/weight/1.08516332
54MP0006072_abnormal_retinal_apoptosis1.07129963
55MP0003890_abnormal_embryonic-extraembry1.05014270
56MP0009053_abnormal_anal_canal1.04549682
57MP0002233_abnormal_nose_morphology1.03256093
58MP0000703_abnormal_thymus_morphology1.02673893
59MP0002638_abnormal_pupillary_reflex1.02145945
60MP0001145_abnormal_male_reproductive1.01995163
61MP0001346_abnormal_lacrimal_gland1.01888784
62MP0003763_abnormal_thymus_physiology0.99096372
63MP0001119_abnormal_female_reproductive0.98741708
64MP0001293_anophthalmia0.98004151
65MP0002160_abnormal_reproductive_system0.97269657
66MP0002234_abnormal_pharynx_morphology0.96434296
67MP0001853_heart_inflammation0.95003399
68* MP0002398_abnormal_bone_marrow0.92384584
69MP0002132_abnormal_respiratory_system0.92198172
70* MP0002722_abnormal_immune_system0.91921428
71MP0000653_abnormal_sex_gland0.90284137
72MP0003941_abnormal_skin_development0.89782712
73MP0008995_early_reproductive_senescence0.88984814
74MP0000358_abnormal_cell_content/0.87172521
75MP0002938_white_spotting0.86504312
76* MP0000689_abnormal_spleen_morphology0.85978462
77MP0004133_heterotaxia0.85798485
78MP0005389_reproductive_system_phenotype0.85303750
79MP0001929_abnormal_gametogenesis0.84666930
80MP0003937_abnormal_limbs/digits/tail_de0.83323218
81MP0005076_abnormal_cell_differentiation0.82537146
82MP0002111_abnormal_tail_morphology0.79076447
83MP0005501_abnormal_skin_physiology0.78966470
84MP0006036_abnormal_mitochondrial_physio0.78547943
85MP0000537_abnormal_urethra_morphology0.76783964
86MP0001881_abnormal_mammary_gland0.75681397
87MP0000762_abnormal_tongue_morphology0.75615884
88* MP0002429_abnormal_blood_cell0.75447893
89MP0005384_cellular_phenotype0.74047352
90* MP0000858_altered_metastatic_potential0.73191890
91MP0003755_abnormal_palate_morphology0.72482529
92MP0003119_abnormal_digestive_system0.71585514
93MP0002161_abnormal_fertility/fecundity0.70624585
94MP0000579_abnormal_nail_morphology0.69326295
95MP0000049_abnormal_middle_ear0.68338967
96MP0003698_abnormal_male_reproductive0.68273457
97MP0009672_abnormal_birth_weight0.67868425
98MP0002796_impaired_skin_barrier0.67756911
99MP0002092_abnormal_eye_morphology0.67326736
100MP0005621_abnormal_cell_physiology0.67188683
101MP0000631_abnormal_neuroendocrine_gland0.66523036
102MP0005023_abnormal_wound_healing0.66357881
103MP0003938_abnormal_ear_development0.66161695
104MP0000647_abnormal_sebaceous_gland0.65297620
105MP0001919_abnormal_reproductive_system0.65108231
106MP0003221_abnormal_cardiomyocyte_apopto0.64971749
107MP0001915_intracranial_hemorrhage0.63647956
108MP0005408_hypopigmentation0.62707003
109MP0009697_abnormal_copulation0.62164774
110MP0003861_abnormal_nervous_system0.61433699
111MP0001286_abnormal_eye_development0.61354886
112MP0002095_abnormal_skin_pigmentation0.60105884
113MP0005391_vision/eye_phenotype0.59712931
114* MP0000716_abnormal_immune_system0.58009171
115MP0001764_abnormal_homeostasis0.57480129
116MP0000566_synostosis0.56937423
117MP0000477_abnormal_intestine_morphology0.54604886
118MP0000750_abnormal_muscle_regeneration0.54376567
119MP0006035_abnormal_mitochondrial_morpho0.54242316
120MP0009250_abnormal_appendicular_skeleto0.53932837
121MP0009703_decreased_birth_body0.53874006
122MP0002751_abnormal_autonomic_nervous0.53695867
123MP0005075_abnormal_melanosome_morpholog0.52406725
124MP0003942_abnormal_urinary_system0.52121284
125MP0000428_abnormal_craniofacial_morphol0.52096528
126MP0005266_abnormal_metabolism0.51501843
127MP0002736_abnormal_nociception_after0.51075075
128MP0005084_abnormal_gallbladder_morpholo0.50877509
129MP0002932_abnormal_joint_morphology0.50476074
130MP0003699_abnormal_female_reproductive0.49565332
131MP0005395_other_phenotype0.48683307
132MP0001727_abnormal_embryo_implantation0.48355133
133MP0004147_increased_porphyrin_level0.47588313

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.24028687
2Reticulocytopenia (HP:0001896)4.85388078
3Abnormality of cells of the erythroid lineage (HP:0012130)4.70898265
4Acute necrotizing encephalopathy (HP:0006965)4.60487779
5Abnormal number of erythroid precursors (HP:0012131)4.55826321
6Breast hypoplasia (HP:0003187)4.30597829
7Abnormal mitochondria in muscle tissue (HP:0008316)4.26096391
8Acute encephalopathy (HP:0006846)4.12837173
9Oral leukoplakia (HP:0002745)3.93769618
10Aplastic anemia (HP:0001915)3.85926604
11Mitochondrial inheritance (HP:0001427)3.79682553
12Progressive macrocephaly (HP:0004481)3.67869518
13Patellar aplasia (HP:0006443)3.65572866
14Chromsome breakage (HP:0040012)3.63504390
15Aplasia/Hypoplasia of the patella (HP:0006498)3.43599920
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.41607767
17Lipid accumulation in hepatocytes (HP:0006561)3.39545238
18Colon cancer (HP:0003003)3.36224180
19Carpal bone hypoplasia (HP:0001498)3.35946887
20Meckel diverticulum (HP:0002245)3.24941167
21Macrocytic anemia (HP:0001972)3.16016680
22Rough bone trabeculation (HP:0100670)3.14199469
23Cerebral edema (HP:0002181)3.12502313
24Selective tooth agenesis (HP:0001592)3.12436365
25Hepatocellular necrosis (HP:0001404)3.12221497
26Abnormality of the ileum (HP:0001549)3.07602623
27Abnormality of the anterior horn cell (HP:0006802)3.06432576
28Degeneration of anterior horn cells (HP:0002398)3.06432576
29Pallor (HP:0000980)3.03927001
30Renal Fanconi syndrome (HP:0001994)2.99056911
31Microretrognathia (HP:0000308)2.97000645
32Abnormality of the preputium (HP:0100587)2.96448744
33Abnormality of chromosome stability (HP:0003220)2.93228617
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.89913641
35Hepatic necrosis (HP:0002605)2.87744924
3611 pairs of ribs (HP:0000878)2.79988090
37Abnormality of the labia minora (HP:0012880)2.73821088
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.73129399
39Duodenal stenosis (HP:0100867)2.72485935
40Small intestinal stenosis (HP:0012848)2.72485935
41Abnormal lung lobation (HP:0002101)2.71208919
42Absent thumb (HP:0009777)2.69918200
43Myelodysplasia (HP:0002863)2.67637653
44Premature graying of hair (HP:0002216)2.66611506
45Septo-optic dysplasia (HP:0100842)2.63275696
46Absent radius (HP:0003974)2.56718458
47Bone marrow hypocellularity (HP:0005528)2.48985543
48Medulloblastoma (HP:0002885)2.44987232
49Neoplasm of the pancreas (HP:0002894)2.44383463
50Abnormality of methionine metabolism (HP:0010901)2.44028300
51Multiple enchondromatosis (HP:0005701)2.43603853
52Cellular immunodeficiency (HP:0005374)2.42698349
53Increased intramyocellular lipid droplets (HP:0012240)2.41146542
54Aplasia involving forearm bones (HP:0009822)2.39235198
55Absent forearm bone (HP:0003953)2.39235198
56Cerebral hypomyelination (HP:0006808)2.39036162
57Microvesicular hepatic steatosis (HP:0001414)2.38327219
58Exercise intolerance (HP:0003546)2.37151408
59Trismus (HP:0000211)2.34235448
60Absent septum pellucidum (HP:0001331)2.32624892
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.32070648
62Leukodystrophy (HP:0002415)2.31232156
63Increased serum pyruvate (HP:0003542)2.30916669
64Lactic acidosis (HP:0003128)2.29693960
65Triphalangeal thumb (HP:0001199)2.29427991
66Horseshoe kidney (HP:0000085)2.28456457
67Abnormal trabecular bone morphology (HP:0100671)2.26085526
68Sloping forehead (HP:0000340)2.24684382
69Abnormality of the septum pellucidum (HP:0007375)2.23930440
70Cleft eyelid (HP:0000625)2.23705747
71Tracheoesophageal fistula (HP:0002575)2.23338703
72Reduced antithrombin III activity (HP:0001976)2.22745219
73Abnormal number of incisors (HP:0011064)2.21516004
74Abnormality of the duodenum (HP:0002246)2.21463604
75Abnormality of glycolysis (HP:0004366)2.21426469
76Respiratory failure (HP:0002878)2.19678744
77Thrombocytosis (HP:0001894)2.19406305
78Respiratory difficulties (HP:0002880)2.19367045
793-Methylglutaconic aciduria (HP:0003535)2.18406287
80Hypoplastic pelvis (HP:0008839)2.18056629
81Atresia of the external auditory canal (HP:0000413)2.17219643
82Megaloblastic anemia (HP:0001889)2.16901948
83Agnosia (HP:0010524)2.16876457
84Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.15401072
85Decreased activity of mitochondrial respiratory chain (HP:0008972)2.15401072
86Impulsivity (HP:0100710)2.13140729
87Poor head control (HP:0002421)2.12263449
88Secondary amenorrhea (HP:0000869)2.11753592
89Duplicated collecting system (HP:0000081)2.11621599
90Pancytopenia (HP:0001876)2.10446371
91Stenosis of the external auditory canal (HP:0000402)2.09926303
92Type I transferrin isoform profile (HP:0003642)2.08515627
93Congenital, generalized hypertrichosis (HP:0004540)2.06155854
94Facial cleft (HP:0002006)2.05554695
95Nephroblastoma (Wilms tumor) (HP:0002667)2.02500261
96Premature ovarian failure (HP:0008209)1.99156557
97Supernumerary spleens (HP:0009799)1.98742428
98Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97377723
99Ectopic kidney (HP:0000086)1.97263485
100Slender long bone (HP:0003100)1.96657126
101Abnormality of the renal collecting system (HP:0004742)1.95187322
102Increased serum lactate (HP:0002151)1.93960066
103Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93264144
104Exertional dyspnea (HP:0002875)1.93037621
105Neoplasm of the colon (HP:0100273)1.92535003
106Abnormality of the heme biosynthetic pathway (HP:0010472)1.91845480
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89367172
108Abnormal protein N-linked glycosylation (HP:0012347)1.89367172
109Abnormal protein glycosylation (HP:0012346)1.89367172
110Abnormal glycosylation (HP:0012345)1.89367172
111Embryonal renal neoplasm (HP:0011794)1.89350534
112Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88036828
113Short thumb (HP:0009778)1.87303642
114Increased muscle lipid content (HP:0009058)1.87303339
115Increased hepatocellular lipid droplets (HP:0006565)1.87182074
116Short middle phalanx of the 5th finger (HP:0004220)1.86274414
117Sparse eyelashes (HP:0000653)1.85049785
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.84721045
119Median cleft lip (HP:0000161)1.83269664
120Increased nuchal translucency (HP:0010880)1.82358198
121Hyperglycinemia (HP:0002154)1.81525007
122Methylmalonic acidemia (HP:0002912)1.79576798
123Abnormality of reticulocytes (HP:0004312)1.79472710
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79114373
125Hypoplasia of the radius (HP:0002984)1.78387137
126Ependymoma (HP:0002888)1.77876077
127Abnormality of the carotid arteries (HP:0005344)1.77621664
128Testicular atrophy (HP:0000029)1.77207637
129Abnormality of renal resorption (HP:0011038)1.76070456
130Optic disc pallor (HP:0000543)1.75815257
131Clubbing of toes (HP:0100760)1.75720352
132Rhabdomyosarcoma (HP:0002859)1.75577873
133Optic nerve coloboma (HP:0000588)1.75227111
134Missing ribs (HP:0000921)1.74842884
135Abnormality of serum amino acid levels (HP:0003112)1.74588864
136Squamous cell carcinoma (HP:0002860)1.73311507
137Duplication of thumb phalanx (HP:0009942)1.72393576
138Glossoptosis (HP:0000162)1.71603542
139Abdominal situs inversus (HP:0003363)1.70767601
140Abnormality of abdominal situs (HP:0011620)1.70767601
141Lymphoma (HP:0002665)1.69326145
142Pulmonary fibrosis (HP:0002206)1.67745589
143Muscle fiber atrophy (HP:0100295)1.66788948
144Progressive muscle weakness (HP:0003323)1.64527243
145Increased CSF lactate (HP:0002490)1.63591850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.83503369
2WEE14.43786819
3VRK24.12761600
4CDC73.65309986
5EIF2AK13.23993381
6PLK42.83806263
7SRPK12.66347438
8NME22.58705177
9NEK22.58002286
10BRSK22.53493605
11TTK2.42112791
12STK162.40471895
13VRK12.34280249
14NEK12.10547924
15PLK12.08025212
16TESK22.03438529
17EIF2AK31.95697031
18ACVR1B1.93745725
19AURKB1.84918385
20BRSK11.73616626
21TLK11.69011468
22MKNK11.63171329
23RPS6KA41.62286300
24CDK71.54666490
25PLK31.54019658
26CCNB11.51853501
27TAF11.46387158
28TSSK61.45776858
29ATR1.44907341
30RPS6KB21.43875776
31MAP3K81.42867007
32DYRK31.40849502
33AURKA1.39236033
34PBK1.37169102
35CHEK21.28113905
36ZAK1.22614626
37PAK41.20015756
38PASK1.18769495
39NUAK11.16779521
40KDR1.14281517
41STK41.13658151
42STK101.12940285
43MKNK21.12146970
44PIM21.10739234
45TRIM281.09058019
46BRAF1.05526115
47CDK81.03449925
48TESK11.01064215
49EPHA20.99652889
50SCYL20.96852403
51TNIK0.95307192
52CHEK10.94936484
53CDK40.94897454
54EIF2AK20.91636050
55ARAF0.83173498
56MAP3K110.79674814
57TGFBR10.78845959
58LRRK20.76543911
59BMPR1B0.75728653
60MAP3K100.72824858
61PAK10.72644569
62MST1R0.70147950
63ATM0.69261497
64PDK20.69259793
65TAOK20.69053450
66CSNK2A10.68173038
67MAP3K120.66120573
68PIM10.65734098
69EEF2K0.65098385
70MAPKAPK30.64002367
71ABL20.63596584
72CDK20.63105149
73FLT30.62070115
74MELK0.61798269
75LATS20.61611879
76NME10.61603882
77STK38L0.61527742
78MET0.58188281
79WNK30.57403634
80ILK0.57219942
81CSNK2A20.57122361
82CLK10.56659634
83LIMK10.51978130
84CDK10.51898729
85RPS6KA50.51546618
86MAP3K90.49077317
87ERBB40.48165786
88CSNK1G10.47183135
89DYRK20.46917285
90CDK90.46380111
91TEC0.46070603
92CSNK1G30.45135796
93MAP2K30.44542097
94PRKCI0.44082858
95BCKDK0.43605601
96STK30.40844272
97MAP4K10.40763424
98PNCK0.39831325
99IRAK30.39582251
100CDK60.38832932
101NEK90.37623291
102CSNK1E0.36869684
103BTK0.36376761
104ALK0.36032344
105PLK20.35483120
106IRAK40.33879609
107CDK190.33266268
108RAF10.28784820
109DAPK10.28381837
110FGFR10.27109923
111CDK180.26364647
112CDK150.25051259
113CDK30.24863727
114CSNK1G20.24861312
115CSNK1A1L0.24770139
116CDK140.23632871
117MARK30.23543334
118AKT20.23474264
119MAP3K30.22409583
120STK240.22096302
121BLK0.21572767
122CDK120.20195048
123MST40.19075117
124MAPKAPK20.18384482
125PRKDC0.18302510
126KIT0.15784120
127LYN0.15425672
128MAP3K50.14827817
129MOS0.14052087
130CDK11A0.13412967
131PAK20.12816629

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.11848467
2Mismatch repair_Homo sapiens_hsa034304.27399223
3Ribosome_Homo sapiens_hsa030104.09702738
4Proteasome_Homo sapiens_hsa030503.76992312
5RNA polymerase_Homo sapiens_hsa030203.40426017
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.30380397
7Spliceosome_Homo sapiens_hsa030403.29308198
8Homologous recombination_Homo sapiens_hsa034403.14992308
9Base excision repair_Homo sapiens_hsa034103.13056622
10Nucleotide excision repair_Homo sapiens_hsa034202.96900408
11RNA transport_Homo sapiens_hsa030132.87565891
12Cell cycle_Homo sapiens_hsa041102.83957536
13Pyrimidine metabolism_Homo sapiens_hsa002402.70886629
14One carbon pool by folate_Homo sapiens_hsa006702.38491406
15Fanconi anemia pathway_Homo sapiens_hsa034602.24908049
16RNA degradation_Homo sapiens_hsa030182.06165261
17Non-homologous end-joining_Homo sapiens_hsa034502.03899312
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93298990
19Basal transcription factors_Homo sapiens_hsa030221.92833749
20p53 signaling pathway_Homo sapiens_hsa041151.70244566
21Protein export_Homo sapiens_hsa030601.42001602
22Purine metabolism_Homo sapiens_hsa002301.41416036
23mRNA surveillance pathway_Homo sapiens_hsa030151.38476216
24Pyruvate metabolism_Homo sapiens_hsa006201.32726223
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27027947
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21340291
27Epstein-Barr virus infection_Homo sapiens_hsa051691.15733504
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08370183
29Systemic lupus erythematosus_Homo sapiens_hsa053221.07903048
30Cardiac muscle contraction_Homo sapiens_hsa042601.03096095
31Fatty acid elongation_Homo sapiens_hsa000621.01158210
32Huntingtons disease_Homo sapiens_hsa050161.00589432
33Oocyte meiosis_Homo sapiens_hsa041140.99291382
34Parkinsons disease_Homo sapiens_hsa050120.96775239
35Propanoate metabolism_Homo sapiens_hsa006400.90655953
36Folate biosynthesis_Homo sapiens_hsa007900.85523090
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84635866
38Herpes simplex infection_Homo sapiens_hsa051680.83639113
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81066694
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.80465805
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78991099
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78659769
43Pentose phosphate pathway_Homo sapiens_hsa000300.78019764
44Oxidative phosphorylation_Homo sapiens_hsa001900.77033287
45Steroid biosynthesis_Homo sapiens_hsa001000.76656347
46Viral carcinogenesis_Homo sapiens_hsa052030.75703061
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73792608
48Antigen processing and presentation_Homo sapiens_hsa046120.70478641
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.69106924
50HTLV-I infection_Homo sapiens_hsa051660.68686535
51Glutathione metabolism_Homo sapiens_hsa004800.67660165
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66938822
53Biosynthesis of amino acids_Homo sapiens_hsa012300.66387828
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65153989
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64460672
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57525677
57Sulfur relay system_Homo sapiens_hsa041220.53663028
58Thyroid cancer_Homo sapiens_hsa052160.53541484
59Selenocompound metabolism_Homo sapiens_hsa004500.53020272
60Legionellosis_Homo sapiens_hsa051340.50695175
61N-Glycan biosynthesis_Homo sapiens_hsa005100.48802963
62MicroRNAs in cancer_Homo sapiens_hsa052060.46665733
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45351669
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44823993
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.42964935
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41911668
67TGF-beta signaling pathway_Homo sapiens_hsa043500.41173220
68Apoptosis_Homo sapiens_hsa042100.41125294
69* Small cell lung cancer_Homo sapiens_hsa052220.40249443
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39993139
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39794071
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39581522
73Carbon metabolism_Homo sapiens_hsa012000.39225236
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37415063
75Vitamin B6 metabolism_Homo sapiens_hsa007500.37216282
76Vitamin digestion and absorption_Homo sapiens_hsa049770.34277704
77Primary immunodeficiency_Homo sapiens_hsa053400.32440395
78Shigellosis_Homo sapiens_hsa051310.32345623
79Alzheimers disease_Homo sapiens_hsa050100.31782587
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31302121
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31131329
82Hepatitis B_Homo sapiens_hsa051610.30069326
83Arginine and proline metabolism_Homo sapiens_hsa003300.30049620
84Sulfur metabolism_Homo sapiens_hsa009200.29062643
85Tyrosine metabolism_Homo sapiens_hsa003500.29004174
86Metabolic pathways_Homo sapiens_hsa011000.28653868
87Galactose metabolism_Homo sapiens_hsa000520.28251200
88Alcoholism_Homo sapiens_hsa050340.28188097
89Hippo signaling pathway_Homo sapiens_hsa043900.28183664
90Colorectal cancer_Homo sapiens_hsa052100.26142485
91Basal cell carcinoma_Homo sapiens_hsa052170.26030233
92Measles_Homo sapiens_hsa051620.25776367
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25699899
94Chemical carcinogenesis_Homo sapiens_hsa052040.25692023
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25549840
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24822064
97Bladder cancer_Homo sapiens_hsa052190.23846236
98Arachidonic acid metabolism_Homo sapiens_hsa005900.23505313
99Wnt signaling pathway_Homo sapiens_hsa043100.22279862
100Asthma_Homo sapiens_hsa053100.21728916
101Peroxisome_Homo sapiens_hsa041460.21718303
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21671995
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21442692
104Retinol metabolism_Homo sapiens_hsa008300.20241002
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.19760435
106Hematopoietic cell lineage_Homo sapiens_hsa046400.19369203
107Renin-angiotensin system_Homo sapiens_hsa046140.19228535
108HIF-1 signaling pathway_Homo sapiens_hsa040660.18840963
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18593949
110Caffeine metabolism_Homo sapiens_hsa002320.18414301
111Fructose and mannose metabolism_Homo sapiens_hsa000510.18286548
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17265271
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14575392
114Notch signaling pathway_Homo sapiens_hsa043300.14369547
115* Pathways in cancer_Homo sapiens_hsa052000.14331121
116Butanoate metabolism_Homo sapiens_hsa006500.13386277
117Influenza A_Homo sapiens_hsa051640.13371639
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12593475
119beta-Alanine metabolism_Homo sapiens_hsa004100.12462839
120Fatty acid metabolism_Homo sapiens_hsa012120.11898402
121Hedgehog signaling pathway_Homo sapiens_hsa043400.11462370
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11088666
123Allograft rejection_Homo sapiens_hsa053300.10329324
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.10291147
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.10170405
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10079347
127Fatty acid degradation_Homo sapiens_hsa000710.10057692
128Phenylalanine metabolism_Homo sapiens_hsa003600.10024668
129Chronic myeloid leukemia_Homo sapiens_hsa052200.09876855
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09876667
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09289892
132Viral myocarditis_Homo sapiens_hsa054160.09287117

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