CKM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of skeletal muscle contraction (GO:0014819)9.95642433
2actin-mediated cell contraction (GO:0070252)8.87534087
3sarcomere organization (GO:0045214)8.47620331
4sarcoplasmic reticulum calcium ion transport (GO:0070296)8.29134895
5skeletal muscle contraction (GO:0003009)7.92840904
6myofibril assembly (GO:0030239)7.35250699
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.26327694
8plasma membrane repair (GO:0001778)7.19099942
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.85562834
10skeletal muscle adaptation (GO:0043501)6.84404844
11actin filament-based movement (GO:0030048)6.64635959
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.45534162
13striated muscle contraction (GO:0006941)6.45342583
14cardiac myofibril assembly (GO:0055003)6.37573019
15carnitine shuttle (GO:0006853)5.91613228
16negative regulation of potassium ion transmembrane transport (GO:1901380)5.89945236
17regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.72116304
18cardiac muscle contraction (GO:0060048)5.71564194
19regulation of cell communication by electrical coupling (GO:0010649)5.64900073
20response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.60716314
21actomyosin structure organization (GO:0031032)5.58511565
22regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.35690436
23tricarboxylic acid cycle (GO:0006099)5.35203042
24regulation of relaxation of muscle (GO:1901077)5.32206692
25* creatine metabolic process (GO:0006600)5.23084593
26regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.13518981
27fatty acid transmembrane transport (GO:1902001)5.05904141
28glycogen catabolic process (GO:0005980)5.03196873
29regulation of actin filament-based movement (GO:1903115)5.02163058
30cardiac muscle cell development (GO:0055013)4.96096956
31muscle contraction (GO:0006936)4.88388830
32regulation of acyl-CoA biosynthetic process (GO:0050812)4.87293325
33skeletal muscle fiber development (GO:0048741)4.78766009
34glucan catabolic process (GO:0009251)4.70098964
35cardiac cell development (GO:0055006)4.65038533
36response to inactivity (GO:0014854)4.63997976
37skeletal muscle tissue development (GO:0007519)4.61998978
38striated muscle adaptation (GO:0014888)4.55299631
39regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.54765062
40striated muscle atrophy (GO:0014891)4.53393687
41skeletal muscle tissue regeneration (GO:0043403)4.53055487
42response to muscle activity (GO:0014850)4.51067079
43regulation of striated muscle contraction (GO:0006942)4.48162873
44muscle system process (GO:0003012)4.44475548
45regulation of coenzyme metabolic process (GO:0051196)4.41346335
46regulation of cofactor metabolic process (GO:0051193)4.41346335
47pyrimidine ribonucleoside catabolic process (GO:0046133)4.40982161
48carnitine transmembrane transport (GO:1902603)4.38298909
49cellular polysaccharide catabolic process (GO:0044247)4.37729515
50heart process (GO:0003015)4.34255645
51heart contraction (GO:0060047)4.34255645
52cytidine deamination (GO:0009972)4.22399061
53cytidine metabolic process (GO:0046087)4.22399061
54cytidine catabolic process (GO:0006216)4.22399061
55cardiac muscle tissue morphogenesis (GO:0055008)4.21234727
56polysaccharide catabolic process (GO:0000272)4.18235366
57adult heart development (GO:0007512)4.13746689
58striated muscle hypertrophy (GO:0014897)4.12642273
59cardiac muscle hypertrophy (GO:0003300)4.10858819
60ventricular cardiac muscle cell action potential (GO:0086005)4.10627010
61muscle fiber development (GO:0048747)4.10378959
62myotube cell development (GO:0014904)4.10343218
63positive regulation of myotube differentiation (GO:0010831)4.06168553
64muscle tissue morphogenesis (GO:0060415)4.05217221
65glucan biosynthetic process (GO:0009250)4.03152903
66glycogen biosynthetic process (GO:0005978)4.03152903
67regulation of membrane repolarization (GO:0060306)4.01583763
68carnitine transport (GO:0015879)3.99126980
69amino-acid betaine transport (GO:0015838)3.99126980
70regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.99002121
71regulation of sarcomere organization (GO:0060297)3.98754341
72muscle cell fate commitment (GO:0042693)3.93649358
73striated muscle cell development (GO:0055002)3.93619994
74muscle atrophy (GO:0014889)3.87801033
75fructose metabolic process (GO:0006000)3.87301212
76regulation of the force of heart contraction (GO:0002026)3.83851175
77muscle organ development (GO:0007517)3.81406106
78muscle organ morphogenesis (GO:0048644)3.81123885
79muscle structure development (GO:0061061)3.80727126
80positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.80427131
81gluconeogenesis (GO:0006094)3.78246051
82muscle adaptation (GO:0043500)3.77612862
83response to activity (GO:0014823)3.75680059
84negative regulation of muscle hypertrophy (GO:0014741)3.74483952
85negative regulation of calcium ion transmembrane transport (GO:1903170)3.69016060
86negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.69016060
87heart trabecula formation (GO:0060347)3.66245526
88regulation of calcium ion transmembrane transport (GO:1903169)3.63958582
89regulation of calcium ion transmembrane transporter activity (GO:1901019)3.63958582
90muscle hypertrophy (GO:0014896)3.63907253
91regulation of sulfur metabolic process (GO:0042762)3.60009594
922-oxoglutarate metabolic process (GO:0006103)3.53944635
93glycogen metabolic process (GO:0005977)3.52647055
94NADH metabolic process (GO:0006734)3.51408015
95cellular glucan metabolic process (GO:0006073)3.45287865
96glucan metabolic process (GO:0044042)3.45287865
97regulation of sequestering of triglyceride (GO:0010889)3.44113304
98regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.38946033
99bundle of His cell to Purkinje myocyte communication (GO:0086069)3.38776674
100positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.38648531
101myoblast fusion (GO:0007520)3.38336424
102hexose biosynthetic process (GO:0019319)3.37181910
103muscle cell development (GO:0055001)3.36693893
104negative regulation of protein localization to cell surface (GO:2000009)3.35612580
105regulation of myoblast differentiation (GO:0045661)3.34105483
106muscle cell cellular homeostasis (GO:0046716)3.33693195
107negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.32108304
108ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.31529286
109positive regulation of cation channel activity (GO:2001259)3.31090533
110regulation of muscle system process (GO:0090257)3.29383485
111neuronal action potential propagation (GO:0019227)3.28912046
112cardiac muscle hypertrophy in response to stress (GO:0014898)3.28465606
113muscle hypertrophy in response to stress (GO:0003299)3.28465606
114cardiac muscle adaptation (GO:0014887)3.28465606
115mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.27452103
116relaxation of muscle (GO:0090075)3.25760171
117striated muscle tissue development (GO:0014706)3.24968447
118mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24580949
119regulation of muscle contraction (GO:0006937)3.24299899
120negative regulation of potassium ion transport (GO:0043267)3.22963740
121oxidative phosphorylation (GO:0006119)3.22239786
122regulation of ATPase activity (GO:0043462)3.21738368
123muscle filament sliding (GO:0030049)10.8047303
124actin-myosin filament sliding (GO:0033275)10.8047303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.10054211
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.62694082
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.83483081
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.71292490
5TBX20_22080862_ChIP-Seq_HEART_Mouse3.48228450
6TBX20_22328084_ChIP-Seq_HEART_Mouse3.48228450
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.38566383
8EP300_21415370_ChIP-Seq_HL-1_Mouse3.25336969
9ZNF263_19887448_ChIP-Seq_K562_Human3.14607557
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.70725802
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.57411361
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.40142000
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.25071364
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08183879
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05161980
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03874485
17BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.82525788
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81170095
19GATA4_21415370_ChIP-Seq_HL-1_Mouse1.79278268
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.78492939
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.77867529
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72524525
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71253641
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.70443599
25CLOCK_20551151_ChIP-Seq_293T_Human1.69626691
26EZH2_22144423_ChIP-Seq_EOC_Human1.60523337
27CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.58754506
28CTCF_27219007_Chip-Seq_Bcells_Human1.57304791
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55062718
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49697440
31NFIB_24661679_ChIP-Seq_LUNG_Mouse1.48039815
32NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.47357055
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44900625
34* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42675535
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.40025085
36PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36573004
37CTCF_21964334_ChIP-Seq_BJAB-B_Human1.35658340
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33537912
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.33043750
40KDM2B_26808549_Chip-Seq_DND41_Human1.32462346
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28251553
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27737475
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25198969
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24500723
45DROSHA_22980978_ChIP-Seq_HELA_Human1.23945135
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.21309416
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20646642
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20540238
49LXR_22292898_ChIP-Seq_THP-1_Human1.19447511
50ZNF274_21170338_ChIP-Seq_K562_Hela1.18757952
51STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.18747812
52RACK7_27058665_Chip-Seq_MCF-7_Human1.17068329
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15589582
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15062630
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14958938
56TP63_22573176_ChIP-Seq_HFKS_Human1.14613791
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.14116119
58SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12169942
59* EZH2_27294783_Chip-Seq_ESCs_Mouse1.10398841
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09007779
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.08343033
62* FOXH1_21741376_ChIP-Seq_ESCs_Human1.08258203
63CTCF_21964334_Chip-Seq_Bcells_Human1.07715488
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07698314
65ATF3_27146783_Chip-Seq_COLON_Human1.06779710
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06529877
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.05399522
68SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05029985
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03548011
70* P68_20966046_ChIP-Seq_HELA_Human1.01740896
71* OCT4_20526341_ChIP-Seq_ESCs_Human1.01653108
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01360322
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.01303177
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01232299
75GATA1_19941827_ChIP-Seq_MEL_Mouse0.99938813
76TP63_17297297_ChIP-ChIP_HaCaT_Human0.99647599
77SPI1_20517297_ChIP-Seq_HL60_Human0.99207459
78* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99115906
79RXR_22158963_ChIP-Seq_LIVER_Mouse0.98630216
80IGF1R_20145208_ChIP-Seq_DFB_Human0.97988046
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97900899
82TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97163514
83* SA1_27219007_Chip-Seq_Bcells_Human0.95798132
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95214113
85BCL6_27268052_Chip-Seq_Bcells_Human0.94234292
86HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93525063
87RUNX1_27514584_Chip-Seq_MCF-7_Human0.93508706
88SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93093011
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.92083491
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91686617
91CJUN_26792858_Chip-Seq_BT549_Human0.91632227
92SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91489437
93CBX2_27304074_Chip-Seq_ESCs_Mouse0.91170286
94E2F1_20622854_ChIP-Seq_HELA_Human0.89712781
95GATA1_19941826_ChIP-Seq_K562_Human0.87711121
96ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87598467
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87418427
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87291219
99* CREB1_26743006_Chip-Seq_LNCaP_Human0.86455861
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86294896
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85354782
102PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85289433
103NANOG_20526341_ChIP-Seq_ESCs_Human0.84437184
104BCOR_27268052_Chip-Seq_Bcells_Human0.83780859
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83502303
106* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83066983
107CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83036468
108ELF1_20517297_ChIP-Seq_JURKAT_Human0.82892802
109EZH2_27294783_Chip-Seq_NPCs_Mouse0.82842378
110GATA1_22025678_ChIP-Seq_K562_Human0.82680022
111PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82060755
112OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81675753
113P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81202709
114RAC3_21632823_ChIP-Seq_H3396_Human0.81060270
115MYC_27129775_Chip-Seq_CORNEA_Mouse0.80817275
116FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80415158
117LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80057054
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80017423
119CSB_26484114_Chip-Seq_FIBROBLAST_Human0.79202956
120MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78987232
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.78712707
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78629715
123CEBPB_22108803_ChIP-Seq_LS180_Human0.78336179
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77935924
125KDM2B_26808549_Chip-Seq_K562_Human0.77922356
126STAT6_21828071_ChIP-Seq_BEAS2B_Human0.76923485
127GATA2_19941826_ChIP-Seq_K562_Human0.76423362
128DPY_21335234_ChIP-Seq_ESCs_Mouse0.76198579
129GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76069099
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.75944230
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.75034894
132EGR1_19032775_ChIP-ChIP_M12_Human0.74588873
133CTCF_26484167_Chip-Seq_Bcells_Mouse0.73116983
134HTT_18923047_ChIP-ChIP_STHdh_Human0.71783549
135TP53_20018659_ChIP-ChIP_R1E_Mouse0.71771356
136ERG_21242973_ChIP-ChIP_JURKAT_Human0.71168501
137GATA3_21867929_ChIP-Seq_CD8_Mouse0.70024271
138GATA6_21074721_ChIP-Seq_CACO-2_Human0.68983355
139* TCF7_22412390_ChIP-Seq_EML_Mouse0.67466286
140JARID2_20075857_ChIP-Seq_MESCs_Mouse0.67363050
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66703869

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.42011483
2MP0000751_myopathy5.78977166
3MP0002837_dystrophic_cardiac_calcinosis5.57835184
4MP0004145_abnormal_muscle_electrophysio5.47097608
5MP0000749_muscle_degeneration5.46826493
6MP0004036_abnormal_muscle_relaxation4.47486973
7MP0004084_abnormal_cardiac_muscle3.93290731
8* MP0002106_abnormal_muscle_physiology3.50488570
9MP0000747_muscle_weakness3.48389065
10MP0004087_abnormal_muscle_fiber3.46899880
11MP0004215_abnormal_myocardial_fiber3.23634941
12MP0000750_abnormal_muscle_regeneration3.20527505
13MP0004130_abnormal_muscle_cell3.13009141
14MP0005330_cardiomyopathy3.08832016
15MP0002269_muscular_atrophy3.07493690
16* MP0005620_abnormal_muscle_contractility3.03520785
17* MP0000759_abnormal_skeletal_muscle3.02626199
18* MP0005369_muscle_phenotype2.90456399
19MP0004233_abnormal_muscle_weight2.24536975
20* MP0002972_abnormal_cardiac_muscle2.22686726
21MP0010630_abnormal_cardiac_muscle2.00465418
22MP0004484_altered_response_of1.96143303
23MP0002332_abnormal_exercise_endurance1.94494278
24MP0003137_abnormal_impulse_conducting1.92322592
25MP0001544_abnormal_cardiovascular_syste1.85586315
26MP0005385_cardiovascular_system_phenoty1.85586315
27MP0008775_abnormal_heart_ventricle1.81937168
28MP0000733_abnormal_muscle_development1.64841145
29* MP0006036_abnormal_mitochondrial_physio1.64200066
30MP0002108_abnormal_muscle_morphology1.62169536
31MP0003221_abnormal_cardiomyocyte_apopto1.59474273
32MP0005666_abnormal_adipose_tissue1.55624817
33MP0004185_abnormal_adipocyte_glucose1.52748225
34MP0006138_congestive_heart_failure1.49367033
35MP0003950_abnormal_plasma_membrane1.39331282
36MP0003828_pulmonary_edema1.31346926
37MP0004085_abnormal_heartbeat1.22796310
38MP0005275_abnormal_skin_tensile1.15201828
39MP0005375_adipose_tissue_phenotype1.13439420
40MP0002127_abnormal_cardiovascular_syste1.11267252
41MP0002234_abnormal_pharynx_morphology1.07351904
42MP0004510_myositis1.06614255
43MP0002971_abnormal_brown_adipose1.04283585
44MP0003705_abnormal_hypodermis_morpholog1.03670280
45MP0006035_abnormal_mitochondrial_morpho1.01817385
46MP0005670_abnormal_white_adipose0.99121532
47MP0000013_abnormal_adipose_tissue0.96364548
48MP0005266_abnormal_metabolism0.96189843
49MP0001661_extended_life_span0.94764163
50MP0000343_altered_response_to0.93075020
51MP0003806_abnormal_nucleotide_metabolis0.88869578
52MP0002822_catalepsy0.85563311
53* MP0000266_abnormal_heart_morphology0.84226097
54MP0003567_abnormal_fetal_cardiomyocyte0.77599314
55MP0009780_abnormal_chondrocyte_physiolo0.74092957
56MP0000003_abnormal_adipose_tissue0.67983258
57MP0004147_increased_porphyrin_level0.62874074
58MP0004043_abnormal_pH_regulation0.61289075
59MP0005165_increased_susceptibility_to0.59836679
60MP0008961_abnormal_basal_metabolism0.57812482
61MP0000372_irregular_coat_pigmentation0.53941247
62MP0008438_abnormal_cutaneous_collagen0.53934241
63MP0003279_aneurysm0.52088480
64* MP0002078_abnormal_glucose_homeostasis0.50267751
65MP0004270_analgesia0.50082264
66MP0003879_abnormal_hair_cell0.49184667
67MP0005334_abnormal_fat_pad0.47386196
68* MP0002128_abnormal_blood_circulation0.47148565
69MP0010368_abnormal_lymphatic_system0.44284613
70MP0005451_abnormal_body_composition0.43861058
71MP0000579_abnormal_nail_morphology0.42931512
72MP0003656_abnormal_erythrocyte_physiolo0.42755903
73MP0003566_abnormal_cell_adhesion0.42252008
74MP0005319_abnormal_enzyme/_coenzyme0.41789298
75MP0000762_abnormal_tongue_morphology0.41204439
76* MP0000230_abnormal_systemic_arterial0.40933878
77MP0010030_abnormal_orbit_morphology0.40238749
78MP0001879_abnormal_lymphatic_vessel0.38612723
79MP0005167_abnormal_blood-brain_barrier0.37961409
80MP0002638_abnormal_pupillary_reflex0.37669066
81MP0001346_abnormal_lacrimal_gland0.37424811
82MP0001299_abnormal_eye_distance/0.37131453
83MP0003045_fibrosis0.35617030
84MP0005503_abnormal_tendon_morphology0.35207648
85MP0004142_abnormal_muscle_tone0.34603774
86MP0002909_abnormal_adrenal_gland0.33854586
87MP0002796_impaired_skin_barrier0.32872746
88MP0005452_abnormal_adipose_tissue0.32852549
89MP0003948_abnormal_gas_homeostasis0.32809356
90MP0005166_decreased_susceptibility_to0.32383050
91MP0005584_abnormal_enzyme/coenzyme_acti0.32230794
92MP0005083_abnormal_biliary_tract0.31011538
93MP0002114_abnormal_axial_skeleton0.30874363
94MP0004134_abnormal_chest_morphology0.30447318
95MP0009115_abnormal_fat_cell0.30174814
96MP0005535_abnormal_body_temperature0.29149971
97MP0000767_abnormal_smooth_muscle0.28871152
98MP0008569_lethality_at_weaning0.28740272
99MP0005623_abnormal_meninges_morphology0.28413465
100MP0002734_abnormal_mechanical_nocicepti0.28121076
101MP0005187_abnormal_penis_morphology0.27434402
102MP0009250_abnormal_appendicular_skeleto0.27392635
103MP0005332_abnormal_amino_acid0.27275245
104MP0002896_abnormal_bone_mineralization0.26920243
105MP0002925_abnormal_cardiovascular_devel0.26301214
106MP0004272_abnormal_basement_membrane0.24908531
107MP0002118_abnormal_lipid_homeostasis0.24055239
108MP0001784_abnormal_fluid_regulation0.23803983
109MP0003959_abnormal_lean_body0.23454635
110MP0009672_abnormal_birth_weight0.21571883
111MP0001943_abnormal_respiration0.21333044
112MP0001614_abnormal_blood_vessel0.20443129
113MP0001853_heart_inflammation0.20384403
114MP0002066_abnormal_motor_capabilities/c0.19811488
115MP0005423_abnormal_somatic_nervous0.19790783
116MP0005376_homeostasis/metabolism_phenot0.19299934
117MP0002970_abnormal_white_adipose0.18024038
118MP0002249_abnormal_larynx_morphology0.14863476
119MP0008874_decreased_physiological_sensi0.14124740
120MP0005386_behavior/neurological_phenoty0.13205962
121MP0004924_abnormal_behavior0.13205962
122MP0006276_abnormal_autonomic_nervous0.12840712

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)8.36198631
2Exercise-induced muscle cramps (HP:0003710)7.80709435
3Muscle fiber inclusion bodies (HP:0100299)7.71287851
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.45344867
5Muscle hypertrophy of the lower extremities (HP:0008968)6.93463496
6Nemaline bodies (HP:0003798)6.82029857
7Calf muscle hypertrophy (HP:0008981)6.64125880
8Type 1 muscle fiber predominance (HP:0003803)6.24952096
9Muscle fiber splitting (HP:0003555)5.99880676
10Distal arthrogryposis (HP:0005684)5.63183782
11Myoglobinuria (HP:0002913)5.54414739
12Hyporeflexia of lower limbs (HP:0002600)5.37065709
13Sudden death (HP:0001699)5.34069950
14Difficulty running (HP:0009046)5.08453030
15Myopathic facies (HP:0002058)4.99896655
16Abnormality of the calf musculature (HP:0001430)4.95257463
17Round ear (HP:0100830)4.83358510
18EMG: myopathic abnormalities (HP:0003458)4.81825739
19Increased connective tissue (HP:0009025)4.73491720
20Abnormality of the left ventricular outflow tract (HP:0011103)4.68896713
21Subaortic stenosis (HP:0001682)4.68896713
22Rhabdomyolysis (HP:0003201)4.50052687
23Ulnar deviation of the wrist (HP:0003049)4.49133426
24Ventricular tachycardia (HP:0004756)4.22770251
25Myotonia (HP:0002486)4.22404663
26Muscle stiffness (HP:0003552)4.20990512
27Calcaneovalgus deformity (HP:0001848)3.78308148
28Asymmetric septal hypertrophy (HP:0001670)3.72239903
29Abnormality of skeletal muscle fiber size (HP:0012084)3.64629769
30Deformed tarsal bones (HP:0008119)3.55526568
31Absent phalangeal crease (HP:0006109)3.50404335
32Difficulty climbing stairs (HP:0003551)3.45059173
33Increased variability in muscle fiber diameter (HP:0003557)3.43968742
34Neck muscle weakness (HP:0000467)3.42676954
35Lipoatrophy (HP:0100578)3.29377414
36Rimmed vacuoles (HP:0003805)3.17407170
37Areflexia of lower limbs (HP:0002522)3.12630761
38Atrial fibrillation (HP:0005110)3.04870238
39Right ventricular cardiomyopathy (HP:0011663)2.93214297
40Dilated cardiomyopathy (HP:0001644)2.89508239
41Abnormal finger flexion creases (HP:0006143)2.87941863
42Primary atrial arrhythmia (HP:0001692)2.84125573
43Frequent falls (HP:0002359)2.82295016
44Distal lower limb muscle weakness (HP:0009053)2.79041841
45Supraventricular tachycardia (HP:0004755)2.73913929
46Bundle branch block (HP:0011710)2.72912569
47Supraventricular arrhythmia (HP:0005115)2.68560797
48Palpitations (HP:0001962)2.63061921
49Malignant hyperthermia (HP:0002047)2.59088847
50EMG: neuropathic changes (HP:0003445)2.53692003
51Mildly elevated creatine phosphokinase (HP:0008180)2.50413492
52Prolonged QT interval (HP:0001657)2.47429424
53Fetal akinesia sequence (HP:0001989)2.46396832
54Ventricular arrhythmia (HP:0004308)2.44015011
55Limb-girdle muscle atrophy (HP:0003797)2.37262012
56Muscular dystrophy (HP:0003560)2.37096820
57Syncope (HP:0001279)2.36728859
58Generalized muscle weakness (HP:0003324)2.32439905
59Hypoplastic ischia (HP:0003175)2.28002308
60Hyperkalemia (HP:0002153)2.27878152
61Heart block (HP:0012722)2.26681021
62Hip contracture (HP:0003273)2.21758818
63Fatigable weakness (HP:0003473)2.21094327
64Abnormality of the neuromuscular junction (HP:0003398)2.21094327
65Facial diplegia (HP:0001349)2.20731673
66Abnormality of the hip-girdle musculature (HP:0001445)2.19692067
67Abnormality of the musculature of the pelvis (HP:0001469)2.19692067
68Lower limb amyotrophy (HP:0007210)2.19431542
69Abnormality of the calcaneus (HP:0008364)2.18804860
70Pelvic girdle muscle weakness (HP:0003749)2.18267587
71Scapular winging (HP:0003691)2.16874480
72Shoulder girdle muscle weakness (HP:0003547)2.16806343
73Abnormal atrioventricular conduction (HP:0005150)2.15785209
74Distal lower limb amyotrophy (HP:0008944)2.15689406
75Gowers sign (HP:0003391)2.15674971
76Proximal amyotrophy (HP:0007126)2.12123516
77Centrally nucleated skeletal muscle fibers (HP:0003687)2.11972149
78Spinal rigidity (HP:0003306)2.11078140
79Limb-girdle muscle weakness (HP:0003325)2.10292472
80Slender build (HP:0001533)2.07476641
81Waddling gait (HP:0002515)2.05858878
82Ragged-red muscle fibers (HP:0003200)2.05276578
83Bulbar palsy (HP:0001283)2.02346492
84Ventricular fibrillation (HP:0001663)1.99235511
85Abnormality of the ischium (HP:0003174)1.98513152
86Atrioventricular block (HP:0001678)1.96536628
87Progressive muscle weakness (HP:0003323)1.96306818
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92361065
89Abnormality of the shoulder girdle musculature (HP:0001435)1.84123742
90Respiratory insufficiency due to muscle weakness (HP:0002747)1.83922473
91Paralysis (HP:0003470)1.83885655
92Left ventricular hypertrophy (HP:0001712)1.81165225
93Exercise intolerance (HP:0003546)1.80790880
94Abnormal EKG (HP:0003115)1.80641015
95Abnormal mitochondria in muscle tissue (HP:0008316)1.79425218
96Weak cry (HP:0001612)1.77343072
97Abnormality of the foot musculature (HP:0001436)1.74632716
98Foot dorsiflexor weakness (HP:0009027)1.72921247
99Acute necrotizing encephalopathy (HP:0006965)1.72841698
100Popliteal pterygium (HP:0009756)1.71829167
101Ketoacidosis (HP:0001993)1.69632041
102Conjunctival hamartoma (HP:0100780)1.69551711
103Palmoplantar keratoderma (HP:0000982)1.69131306
104Hepatic necrosis (HP:0002605)1.67999730
105Cholelithiasis (HP:0001081)1.66549708
106Metatarsus adductus (HP:0001840)1.66283840
107Increased muscle lipid content (HP:0009058)1.65121970
108Testicular atrophy (HP:0000029)1.64856535
109Increased intramyocellular lipid droplets (HP:0012240)1.61884026
110Nonprogressive disorder (HP:0003680)1.57488776
111Type 2 muscle fiber atrophy (HP:0003554)1.56005889
112Long clavicles (HP:0000890)1.53060949
113Ulnar deviation of finger (HP:0009465)1.50219612
114Limited hip movement (HP:0008800)1.47714906
115Muscle fiber atrophy (HP:0100295)1.45959967
116Steppage gait (HP:0003376)1.35311220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.14138536
2TTN6.65133833
3PHKG15.41719201
4PHKG25.41719201
5NME12.77634636
6PDK32.74615724
7PDK42.74615724
8TRIB32.49278465
9DMPK2.49014927
10NEK12.48076658
11PIK3CG2.43002250
12MAP2K32.15673223
13PINK12.13259793
14PIK3CA2.09664427
15BCKDK2.04263614
16MUSK1.90196596
17PKN21.84781561
18MAP3K71.77571882
19PDK21.73547275
20LMTK21.63848534
21MYLK1.58379570
22MAPK121.46620918
23STK241.34049142
24TIE11.21380844
25MAPKAPK31.08965068
26MARK11.02282810
27MAP2K40.99056611
28MAP3K30.93501968
29MOS0.93334334
30PRKAA20.92155322
31PRKAA10.91038177
32MAP2K60.89666116
33ILK0.84727898
34TRPM70.82200292
35CCNB10.81527904
36RIPK10.76322945
37DYRK1B0.73978503
38NEK90.72459514
39PRKD10.72308459
40ZAK0.69530543
41EPHB10.64661834
42MAP3K130.61901919
43CAMK2D0.60652465
44ROCK10.60300791
45MAP3K50.59731044
46SIK10.55449199
47AKT20.52425397
48GRK70.52077338
49PAK30.51592512
50CAMK2G0.50750007
51PKN10.49293404
52INSRR0.44922343
53MAPK110.44788302
54TAOK10.44480983
55CAMK2B0.43753468
56PTK60.42327670
57MAP3K110.40843658
58TGFBR20.39972136
59TAOK20.39380393
60PRKACB0.39115583
61FLT30.38516646
62PDGFRA0.32762745
63CDC42BPA0.30521268
64TBK10.30362851
65ROCK20.30163217
66PRKACA0.29284068
67CAMK40.28430026
68STK38L0.28108930
69PDPK10.28078525
70SGK10.26475066
71SGK20.25980924
72PTK2B0.25271367
73ICK0.25038515
74EEF2K0.24886736
75MAP3K10.24789852
76PRPF4B0.24744270
77STK380.24245953
78PRKG10.23399887
79ERBB30.23047128
80CAMK2A0.22165757
81MAPK100.22142883
82RPS6KB10.21976066
83PDK10.21872334
84ARAF0.21562877
85PRKACG0.20650686
86RPS6KA30.20143215
87RPS6KB20.20056899
88LATS10.19677742
89MAPK130.19092264
90MAPK70.18920255
91DAPK30.18272586
92RPS6KA10.17831829
93FER0.17498850
94RPS6KC10.17468218
95RPS6KL10.17468218
96MAP3K100.16608550
97STK40.16584706
98MARK20.16229479
99WNK10.16035981
100CAMK10.15459067
101LIMK10.15065206
102KDR0.14629995
103LATS20.14427671
104LRRK20.13859527
105MAP3K60.13625953
106MAPK40.13485114
107MTOR0.13028710
108RPS6KA60.12170735
109ZAP700.12052201
110WNK40.11956346
111CDK190.11870447
112ERN10.11662280
113KSR20.11311630
114MAP2K10.10736869
115EPHA30.10280649
116SGK30.10248940
117CAMK1G0.09946865
118DAPK20.09686844
119RAF10.09543292
120RET0.09524854
121SGK2230.08628054
122SGK4940.08628054
123MARK30.07560707
124BRAF0.07198155
125STK110.06141753
126NLK0.05180336

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.37053534
2Cardiac muscle contraction_Homo sapiens_hsa042604.13538890
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.08124563
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.03417299
5Dilated cardiomyopathy_Homo sapiens_hsa054143.76417031
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.14759858
7Propanoate metabolism_Homo sapiens_hsa006402.92599536
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83027720
9Parkinsons disease_Homo sapiens_hsa050122.60508175
10Oxidative phosphorylation_Homo sapiens_hsa001902.42613733
11Carbon metabolism_Homo sapiens_hsa012002.40144521
12Fatty acid degradation_Homo sapiens_hsa000712.34109442
13Alzheimers disease_Homo sapiens_hsa050102.10640162
14Starch and sucrose metabolism_Homo sapiens_hsa005001.98350773
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96922901
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90717427
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.81890146
18Fatty acid metabolism_Homo sapiens_hsa012121.74211829
19Viral myocarditis_Homo sapiens_hsa054161.69845993
20Glucagon signaling pathway_Homo sapiens_hsa049221.67542120
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65280115
22Pyruvate metabolism_Homo sapiens_hsa006201.64561250
23Insulin resistance_Homo sapiens_hsa049311.62165673
24Insulin signaling pathway_Homo sapiens_hsa049101.58426522
25Huntingtons disease_Homo sapiens_hsa050161.43169801
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.42126726
27Oxytocin signaling pathway_Homo sapiens_hsa049211.36871962
28Biosynthesis of amino acids_Homo sapiens_hsa012301.29880699
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26598986
30Calcium signaling pathway_Homo sapiens_hsa040201.21937081
31Circadian rhythm_Homo sapiens_hsa047101.21863664
32AMPK signaling pathway_Homo sapiens_hsa041521.19419929
33cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16958869
34Galactose metabolism_Homo sapiens_hsa000521.10772692
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03639154
36Tight junction_Homo sapiens_hsa045300.95643245
37Focal adhesion_Homo sapiens_hsa045100.93891041
38Butanoate metabolism_Homo sapiens_hsa006500.93773375
39Fructose and mannose metabolism_Homo sapiens_hsa000510.93510406
40PPAR signaling pathway_Homo sapiens_hsa033200.92535816
41Fatty acid elongation_Homo sapiens_hsa000620.86814567
42Nitrogen metabolism_Homo sapiens_hsa009100.86621808
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.85513443
44Arginine biosynthesis_Homo sapiens_hsa002200.77733485
45Long-term potentiation_Homo sapiens_hsa047200.77530135
46HIF-1 signaling pathway_Homo sapiens_hsa040660.74053422
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72308247
48Gastric acid secretion_Homo sapiens_hsa049710.70799833
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.70306420
50beta-Alanine metabolism_Homo sapiens_hsa004100.65438265
51Fatty acid biosynthesis_Homo sapiens_hsa000610.64620490
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64388409
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62705824
54Renin secretion_Homo sapiens_hsa049240.57296286
55Type II diabetes mellitus_Homo sapiens_hsa049300.56296922
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55074484
57GnRH signaling pathway_Homo sapiens_hsa049120.51571111
58Pentose phosphate pathway_Homo sapiens_hsa000300.51000975
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46902292
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46154010
61Tryptophan metabolism_Homo sapiens_hsa003800.45444751
62VEGF signaling pathway_Homo sapiens_hsa043700.43874455
63Amoebiasis_Homo sapiens_hsa051460.43468269
64Lysine degradation_Homo sapiens_hsa003100.42820359
65FoxO signaling pathway_Homo sapiens_hsa040680.41891726
66Adherens junction_Homo sapiens_hsa045200.41197069
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40482830
68Insulin secretion_Homo sapiens_hsa049110.40344862
69Phenylalanine metabolism_Homo sapiens_hsa003600.40025568
70ECM-receptor interaction_Homo sapiens_hsa045120.39707974
71mTOR signaling pathway_Homo sapiens_hsa041500.39642931
72* Arginine and proline metabolism_Homo sapiens_hsa003300.38037276
73Platelet activation_Homo sapiens_hsa046110.36774171
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.35013112
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33203650
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33173432
77Peroxisome_Homo sapiens_hsa041460.32904595
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31477829
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31473732
80MAPK signaling pathway_Homo sapiens_hsa040100.28052939
81Proteoglycans in cancer_Homo sapiens_hsa052050.27684503
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27011745
83Long-term depression_Homo sapiens_hsa047300.26474367
84Amphetamine addiction_Homo sapiens_hsa050310.26337425
85cAMP signaling pathway_Homo sapiens_hsa040240.25085852
86Renal cell carcinoma_Homo sapiens_hsa052110.24203476
87Histidine metabolism_Homo sapiens_hsa003400.23516823
88Regulation of autophagy_Homo sapiens_hsa041400.21046779
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20122493
90Fat digestion and absorption_Homo sapiens_hsa049750.17938235
91Glioma_Homo sapiens_hsa052140.17279062
92Pancreatic secretion_Homo sapiens_hsa049720.16475737
93Ovarian steroidogenesis_Homo sapiens_hsa049130.16304046
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15190890
95Circadian entrainment_Homo sapiens_hsa047130.14897088
96Sulfur relay system_Homo sapiens_hsa041220.14653032
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14257052
98* Metabolic pathways_Homo sapiens_hsa011000.13762198
99Purine metabolism_Homo sapiens_hsa002300.12155458
100Cholinergic synapse_Homo sapiens_hsa047250.10712222
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.10587538
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09457307
103Tyrosine metabolism_Homo sapiens_hsa003500.07727503
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.06827743
105Dorso-ventral axis formation_Homo sapiens_hsa043200.06266127
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.05086281
107Bile secretion_Homo sapiens_hsa049760.04713272
108Toxoplasmosis_Homo sapiens_hsa051450.04324145
109Gap junction_Homo sapiens_hsa045400.03872677
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03578886
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.03438232
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.02232153
113Acute myeloid leukemia_Homo sapiens_hsa052210.01056221
114Glycerolipid metabolism_Homo sapiens_hsa005610.00994283
115Melanogenesis_Homo sapiens_hsa049160.00963150
116Salivary secretion_Homo sapiens_hsa04970-0.0098485

Most similar genes based on co-expression Upload to Enrichr

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