CKLF-CMTM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring CKLF (chemokine-like factor) and CMTM1 (CKLF-like MARVEL transmembrane domain containing 1) genes on chromosome 16. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.62269411
2cytidine metabolic process (GO:0046087)5.58276763
3cytidine catabolic process (GO:0006216)5.58276763
4cytidine deamination (GO:0009972)5.58276763
5pyrimidine ribonucleoside catabolic process (GO:0046133)5.00929907
6neutrophil activation involved in immune response (GO:0002283)4.86018874
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64263920
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.62665615
9protein neddylation (GO:0045116)4.57032124
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.36851878
11neutrophil activation (GO:0042119)4.36839683
12positive regulation of macrophage differentiation (GO:0045651)4.21214825
13granulocyte activation (GO:0036230)4.13529791
14lymphocyte chemotaxis (GO:0048247)4.09568950
15cellular response to interleukin-15 (GO:0071350)4.08008605
16T cell migration (GO:0072678)3.92924828
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.89475839
18negative regulation of T cell apoptotic process (GO:0070233)3.85650565
19regulation of regulatory T cell differentiation (GO:0045589)3.85346400
20positive regulation of alpha-beta T cell proliferation (GO:0046641)3.77274548
21dendritic cell chemotaxis (GO:0002407)3.76236007
22mast cell activation (GO:0045576)3.74409976
23leukocyte degranulation (GO:0043299)3.70656842
24regulation of B cell receptor signaling pathway (GO:0050855)3.69956100
25positive regulation of monocyte chemotaxis (GO:0090026)3.61367132
26positive regulation of T cell mediated cytotoxicity (GO:0001916)3.61069012
27ATP synthesis coupled proton transport (GO:0015986)3.52114698
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.52114698
29gonadal mesoderm development (GO:0007506)3.51801341
30regulation of alpha-beta T cell proliferation (GO:0046640)3.49933917
31mast cell activation involved in immune response (GO:0002279)3.48134959
32mast cell degranulation (GO:0043303)3.48134959
33regulation of T cell mediated cytotoxicity (GO:0001914)3.47971871
34positive regulation of gamma-delta T cell activation (GO:0046645)3.46636932
35purinergic nucleotide receptor signaling pathway (GO:0035590)3.43512703
36tolerance induction (GO:0002507)3.39676274
37response to interleukin-15 (GO:0070672)3.39622769
38Arp2/3 complex-mediated actin nucleation (GO:0034314)3.39050811
39G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.38350236
40positive regulation of interleukin-8 secretion (GO:2000484)3.34319741
41thrombin receptor signaling pathway (GO:0070493)3.34144968
42regulation of memory T cell differentiation (GO:0043380)3.29608045
43dendritic cell migration (GO:0036336)3.29390508
44negative regulation of cell killing (GO:0031342)3.28518962
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.28518962
46pyrimidine nucleoside catabolic process (GO:0046135)3.27420517
47positive regulation of T cell chemotaxis (GO:0010820)3.18083139
48regulation of T cell chemotaxis (GO:0010819)3.18083139
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16801270
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16801270
51immunoglobulin mediated immune response (GO:0016064)3.14237321
52regulation of germinal center formation (GO:0002634)3.11585270
53cellular defense response (GO:0006968)3.11353020
54myeloid cell activation involved in immune response (GO:0002275)3.07920011
55regulation of T cell apoptotic process (GO:0070232)3.05204456
56positive regulation of lymphocyte migration (GO:2000403)3.00052909
57actin nucleation (GO:0045010)2.99120778
58regulation of leukocyte mediated cytotoxicity (GO:0001910)2.98219336
59positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.98103230
60regulation of activation of Janus kinase activity (GO:0010533)2.97301401
61B cell mediated immunity (GO:0019724)2.93434176
62regulation of lymphocyte chemotaxis (GO:1901623)2.92894502
63autophagic vacuole fusion (GO:0000046)2.91279508
64regulation of T-helper 1 type immune response (GO:0002825)2.91252546
65lipoxygenase pathway (GO:0019372)2.89939329
66negative regulation of heart rate (GO:0010459)2.85710248
67positive regulation of mast cell activation (GO:0033005)2.85181791
68regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.85016545
69response to interferon-beta (GO:0035456)2.83528503
70regulation of cell killing (GO:0031341)2.83208034
71macrophage chemotaxis (GO:0048246)2.83188740
72positive regulation of T cell migration (GO:2000406)2.82913932
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.81093470
74lymphocyte migration (GO:0072676)2.79924772
75negative regulation of lymphocyte apoptotic process (GO:0070229)2.79107619
76respiratory electron transport chain (GO:0022904)2.77506997
77regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.76701048
78antigen processing and presentation via MHC class Ib (GO:0002475)2.75313233
79electron transport chain (GO:0022900)2.74781119
80regulation of interleukin-8 secretion (GO:2000482)2.73902346
81regulation of T cell receptor signaling pathway (GO:0050856)2.73775472
82cyclooxygenase pathway (GO:0019371)2.72175750
83positive regulation of interleukin-1 beta secretion (GO:0050718)2.71337413
84regulation of chronic inflammatory response (GO:0002676)2.70773245
85negative T cell selection (GO:0043383)2.70561646
86positive regulation of T-helper 1 type immune response (GO:0002827)2.69811443
87regulation of T cell migration (GO:2000404)2.68165844
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67989093
89regulation of mast cell activation (GO:0033003)2.65157945
90positive regulation of cell killing (GO:0031343)2.63934491
91T cell costimulation (GO:0031295)2.63724215
92eosinophil chemotaxis (GO:0048245)2.63250478
93purinergic receptor signaling pathway (GO:0035587)2.62767261
94lymphocyte costimulation (GO:0031294)2.59969384
95hepatocyte apoptotic process (GO:0097284)2.58805398
96positive regulation of defense response to virus by host (GO:0002230)2.58403018
97regulation of macrophage differentiation (GO:0045649)2.57630945
98T cell receptor signaling pathway (GO:0050852)2.57565532
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.56266642
100antigen receptor-mediated signaling pathway (GO:0050851)2.55228804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.56608884
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.76027242
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.60328218
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.50138072
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.43770099
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.21595343
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20025635
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.19175002
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.05375463
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.74537845
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.67304025
12SCL_19346495_ChIP-Seq_HPC-7_Human2.64201195
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.62711773
14MYB_26560356_Chip-Seq_TH2_Human2.43798140
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43697413
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.39698741
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27491912
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21873383
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.11160362
20RUNX_20019798_ChIP-Seq_JUKART_Human2.10742364
21SPI1_23547873_ChIP-Seq_NB4_Human2.06867646
22GATA3_26560356_Chip-Seq_TH2_Human2.06739025
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06428151
24VDR_23849224_ChIP-Seq_CD4+_Human2.02317123
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01101658
26STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00059648
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99246144
28ELK1_19687146_ChIP-ChIP_HELA_Human1.85454450
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.84694580
30GATA3_27048872_Chip-Seq_THYMUS_Human1.69227912
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68974245
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65153715
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62409195
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61690877
35FOXP3_21729870_ChIP-Seq_TREG_Human1.58790528
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56940892
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.56285616
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53712090
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53382374
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52253455
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50226877
42VDR_22108803_ChIP-Seq_LS180_Human1.48272262
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.43191277
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.40648645
45MYB_26560356_Chip-Seq_TH1_Human1.40210283
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32772704
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.32299536
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32299536
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32138225
50UTX_26944678_Chip-Seq_JUKART_Human1.30259283
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27835484
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27721433
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.27069645
54TAF15_26573619_Chip-Seq_HEK293_Human1.25466224
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23496953
56FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23355506
57TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.21748956
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21549660
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20275824
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17241464
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16488772
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15850823
63AR_20517297_ChIP-Seq_VCAP_Human1.14842257
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14832646
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14699855
66TP53_22573176_ChIP-Seq_HFKS_Human1.13479440
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.12750639
68SPI1_23127762_ChIP-Seq_K562_Human1.12735922
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12364581
70IRF1_19129219_ChIP-ChIP_H3396_Human1.11712715
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11640660
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09039847
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07628865
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07589686
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.07322016
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.05616556
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04692314
78SALL4_22934838_ChIP-ChIP_CD34+_Human1.02533622
79GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97614070
80POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96991258
81ETS1_20019798_ChIP-Seq_JURKAT_Human0.95890911
82MYC_18940864_ChIP-ChIP_HL60_Human0.95230936
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94876044
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94483494
85NFE2_27457419_Chip-Seq_LIVER_Mouse0.93955628
86EWS_26573619_Chip-Seq_HEK293_Human0.93557666
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92090271
88NANOG_20526341_ChIP-Seq_ESCs_Human0.91001872
89BCL6_27268052_Chip-Seq_Bcells_Human0.90852163
90RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90120875
91SMRT_27268052_Chip-Seq_Bcells_Human0.90065032
92P300_27268052_Chip-Seq_Bcells_Human0.89444502
93NANOG_19829295_ChIP-Seq_ESCs_Human0.88511034
94SOX2_19829295_ChIP-Seq_ESCs_Human0.88511034
95HTT_18923047_ChIP-ChIP_STHdh_Human0.88491063
96MAF_26560356_Chip-Seq_TH2_Human0.87456147
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87287572
98ERG_20517297_ChIP-Seq_VCAP_Human0.86691703
99ER_23166858_ChIP-Seq_MCF-7_Human0.86568018
100TAF2_19829295_ChIP-Seq_ESCs_Human0.85941633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.49556357
2MP0001835_abnormal_antigen_presentation3.83680684
3MP0005464_abnormal_platelet_physiology3.78163060
4MP0003724_increased_susceptibility_to3.66771432
5MP0003806_abnormal_nucleotide_metabolis3.56535866
6MP0002148_abnormal_hypersensitivity_rea3.14932880
7MP0005000_abnormal_immune_tolerance2.77174649
8MP0003763_abnormal_thymus_physiology2.74721511
9MP0009785_altered_susceptibility_to2.74164221
10MP0001800_abnormal_humoral_immune2.67075503
11MP0002723_abnormal_immune_serum2.57055899
12MP0003436_decreased_susceptibility_to2.54581873
13MP0002452_abnormal_antigen_presenting2.33989962
14MP0001819_abnormal_immune_cell2.32877843
15MP0002420_abnormal_adaptive_immunity2.31837403
16MP0003866_abnormal_defecation2.31179994
17MP0005025_abnormal_response_to2.30558924
18MP0001790_abnormal_immune_system2.25472984
19MP0005387_immune_system_phenotype2.25472984
20MP0000685_abnormal_immune_system2.24671381
21MP0000465_gastrointestinal_hemorrhage2.08512245
22MP0002419_abnormal_innate_immunity1.97567799
23MP0002398_abnormal_bone_marrow1.95992486
24MP0009333_abnormal_splenocyte_physiolog1.94841911
25MP0009764_decreased_sensitivity_to1.92713476
26MP0002638_abnormal_pupillary_reflex1.88092151
27MP0006082_CNS_inflammation1.87807220
28MP0000716_abnormal_immune_system1.77779010
29MP0004147_increased_porphyrin_level1.75514580
30MP0001986_abnormal_taste_sensitivity1.72929354
31MP0010155_abnormal_intestine_physiology1.70667282
32MP0001845_abnormal_inflammatory_respons1.69291076
33MP0000343_altered_response_to1.63779142
34MP0002722_abnormal_immune_system1.63218841
35MP0002405_respiratory_system_inflammati1.59065415
36MP0000689_abnormal_spleen_morphology1.57397318
37MP0002429_abnormal_blood_cell1.46590074
38MP0001533_abnormal_skeleton_physiology1.44787439
39MP0000569_abnormal_digit_pigmentation1.40749154
40MP0009763_increased_sensitivity_to1.30617805
41MP0009765_abnormal_xenobiotic_induced1.30513610
42MP0000703_abnormal_thymus_morphology1.28768132
43MP0001919_abnormal_reproductive_system1.26722719
44MP0008877_abnormal_DNA_methylation1.25368996
45MP0008469_abnormal_protein_level1.24905379
46MP0008872_abnormal_physiological_respon1.23418837
47MP0008875_abnormal_xenobiotic_pharmacok1.22083556
48MP0004947_skin_inflammation1.20771930
49MP0005084_abnormal_gallbladder_morpholo1.20114426
50MP0002736_abnormal_nociception_after1.17838149
51MP0001542_abnormal_bone_strength1.14590933
52MP0005075_abnormal_melanosome_morpholog1.13073492
53MP0003638_abnormal_response/metabolism_1.08588879
54MP0004142_abnormal_muscle_tone1.07226854
55MP0006072_abnormal_retinal_apoptosis1.05407346
56MP0001905_abnormal_dopamine_level1.04536637
57MP0002876_abnormal_thyroid_physiology1.02705319
58MP0000858_altered_metastatic_potential1.00567960
59MP0006036_abnormal_mitochondrial_physio0.99805806
60MP0003303_peritoneal_inflammation0.97385310
61MP0000372_irregular_coat_pigmentation0.95085920
62MP0003252_abnormal_bile_duct0.95085898
63MP0001853_heart_inflammation0.94501106
64MP0001968_abnormal_touch/_nociception0.93832266
65MP0005166_decreased_susceptibility_to0.89958222
66MP0005410_abnormal_fertilization0.89909297
67MP0001851_eye_inflammation0.89725329
68MP0005389_reproductive_system_phenotype0.88583791
69MP0004145_abnormal_muscle_electrophysio0.87606333
70MP0008004_abnormal_stomach_pH0.87385759
71MP0002166_altered_tumor_susceptibility0.85671472
72MP0005174_abnormal_tail_pigmentation0.84950241
73MP0009379_abnormal_foot_pigmentation0.83152059
74MP0003045_fibrosis0.80968217
75MP0003075_altered_response_to0.80183264
76MP0003448_altered_tumor_morphology0.77679801
77MP0003011_delayed_dark_adaptation0.77276943
78MP0001765_abnormal_ion_homeostasis0.77183013
79MP0002928_abnormal_bile_duct0.76943916
80MP0002277_abnormal_respiratory_mucosa0.76605567
81MP0000230_abnormal_systemic_arterial0.74633315
82MP0010386_abnormal_urinary_bladder0.73602622
83MP0005646_abnormal_pituitary_gland0.73134723
84MP0005253_abnormal_eye_physiology0.70569103
85MP0002095_abnormal_skin_pigmentation0.70254309
86MP0004885_abnormal_endolymph0.69306963
87MP0000015_abnormal_ear_pigmentation0.68996029
88MP0001970_abnormal_pain_threshold0.68715697
89MP0001501_abnormal_sleep_pattern0.68633460
90MP0004883_abnormal_blood_vessel0.68053021
91MP0002019_abnormal_tumor_incidence0.67747509
92MP0002733_abnormal_thermal_nociception0.67382807
93MP0002693_abnormal_pancreas_physiology0.65947308
94MP0008873_increased_physiological_sensi0.64603937
95MP0002102_abnormal_ear_morphology0.63090503
96MP0001727_abnormal_embryo_implantation0.62160176
97MP0005266_abnormal_metabolism0.61124697
98MP0003195_calcinosis0.60451597
99MP0003786_premature_aging0.59780817
100MP0000516_abnormal_urinary_system0.59664076

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.77884045
23-Methylglutaconic aciduria (HP:0003535)4.71233683
3T lymphocytopenia (HP:0005403)4.11780480
4Abnormality of T cell number (HP:0011839)4.09040944
5Elevated erythrocyte sedimentation rate (HP:0003565)4.04383557
6Stomatitis (HP:0010280)3.95769690
7Petechiae (HP:0000967)3.90622280
8Abnormality of T cells (HP:0002843)3.74847195
9Acute necrotizing encephalopathy (HP:0006965)3.61535414
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.59908739
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.59908739
12Prolonged bleeding time (HP:0003010)3.51136944
13Aplastic anemia (HP:0001915)3.42705339
14Abnormality of T cell physiology (HP:0011840)3.37122132
15Abnormal mitochondria in muscle tissue (HP:0008316)3.35595416
16Obstructive lung disease (HP:0006536)3.24158400
17Chronic obstructive pulmonary disease (HP:0006510)3.24158400
18Mitochondrial inheritance (HP:0001427)3.13507401
19Abnormality of B cell number (HP:0010975)3.10125823
20B lymphocytopenia (HP:0010976)2.98163270
21Abnormality of eosinophils (HP:0001879)2.96656893
22IgM deficiency (HP:0002850)2.96639545
23Chronic diarrhea (HP:0002028)2.95301890
24Progressive macrocephaly (HP:0004481)2.92910688
25Acute encephalopathy (HP:0006846)2.89534168
26Abnormality of the prostate (HP:0008775)2.88575064
27Severe combined immunodeficiency (HP:0004430)2.88134897
28Recurrent fungal infections (HP:0002841)2.81275079
29Abnormality of macrophages (HP:0004311)2.77451628
30Eosinophilia (HP:0001880)2.76296266
31Encephalitis (HP:0002383)2.73951735
32Purpura (HP:0000979)2.73888890
33Joint swelling (HP:0001386)2.73229564
34Congenital, generalized hypertrichosis (HP:0004540)2.72520898
35Eczematoid dermatitis (HP:0000976)2.67629530
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.64511868
37Increased CSF lactate (HP:0002490)2.62616312
38Epistaxis (HP:0000421)2.55523235
39Myositis (HP:0100614)2.54507968
40Retrobulbar optic neuritis (HP:0100654)2.53783066
41Optic neuritis (HP:0100653)2.53783066
42Increased IgM level (HP:0003496)2.53456480
43Menorrhagia (HP:0000132)2.52255333
44Vasculitis (HP:0002633)2.51686421
45Hypoproteinemia (HP:0003075)2.50564242
46Renal Fanconi syndrome (HP:0001994)2.48295601
47Granulocytopenia (HP:0001913)2.45644349
48Meningitis (HP:0001287)2.45075768
49Hepatosplenomegaly (HP:0001433)2.44373547
50Recurrent bronchitis (HP:0002837)2.44033874
51Leukocytosis (HP:0001974)2.42749406
52Chronic mucocutaneous candidiasis (HP:0002728)2.41409258
53Recurrent cutaneous fungal infections (HP:0011370)2.41409258
54Autoimmune hemolytic anemia (HP:0001890)2.40486652
55Renal cortical cysts (HP:0000803)2.30757799
56Panhypogammaglobulinemia (HP:0003139)2.28013083
57IgA deficiency (HP:0002720)2.26461916
58Increased intramyocellular lipid droplets (HP:0012240)2.25730065
59Agammaglobulinemia (HP:0004432)2.25137718
60Orchitis (HP:0100796)2.23997162
61Recurrent bacterial skin infections (HP:0005406)2.20687847
62Abnormal platelet volume (HP:0011876)2.17412190
63Anorexia (HP:0002039)2.16922685
64Combined immunodeficiency (HP:0005387)2.13967237
65Hepatic necrosis (HP:0002605)2.08108293
66Cerebral palsy (HP:0100021)2.06163849
67Increased mean platelet volume (HP:0011877)2.05530117
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05246592
69Type I transferrin isoform profile (HP:0003642)2.03133543
70Leukodystrophy (HP:0002415)2.03102818
71Gingival bleeding (HP:0000225)2.02670869
72Recurrent abscess formation (HP:0002722)2.02432305
73Hemoptysis (HP:0002105)2.02052785
74Hepatocellular necrosis (HP:0001404)2.01620483
75Pustule (HP:0200039)2.01456506
76Exertional dyspnea (HP:0002875)2.01295442
77Cerebral edema (HP:0002181)2.00307294
78Methylmalonic acidemia (HP:0002912)2.00097282
79Abnormality of the renal cortex (HP:0011035)1.99871416
80Abnormality of midbrain morphology (HP:0002418)1.99062928
81Molar tooth sign on MRI (HP:0002419)1.99062928
82Thyroiditis (HP:0100646)1.98699326
83Recurrent viral infections (HP:0004429)1.97082956
84Hyperlipoproteinemia (HP:0010980)1.96996410
85Congenital stationary night blindness (HP:0007642)1.96868320
86Gangrene (HP:0100758)1.95074422
87Abnormality of alanine metabolism (HP:0010916)1.94275939
88Hyperalaninemia (HP:0003348)1.94275939
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94275939
90Increased muscle lipid content (HP:0009058)1.94260580
91Prostate neoplasm (HP:0100787)1.93717954
92Recurrent skin infections (HP:0001581)1.91439181
93Abnormality of male internal genitalia (HP:0000022)1.91097162
94Pancytopenia (HP:0001876)1.91007260
95Optic disc pallor (HP:0000543)1.90048199
96Neutropenia (HP:0001875)1.88782154
97Increased hepatocellular lipid droplets (HP:0006565)1.87378377
98Lipid accumulation in hepatocytes (HP:0006561)1.86475043
99Pulmonary fibrosis (HP:0002206)1.80982994
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80910047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.92741533
2RIPK43.62050249
3TAOK33.35235259
4TESK23.11835062
5GRK62.92978767
6NUAK12.68135136
7TLK12.22208771
8FES2.17274291
9SYK2.09692983
10BMPR21.96687948
11ITK1.92393666
12MAP3K121.90806144
13MAP4K11.89461857
14TEC1.85127353
15KDR1.83148883
16ZAP701.81542899
17ADRBK21.79943232
18BLK1.78014560
19MAP4K21.77521955
20BTK1.75995162
21MST41.69124934
22CSK1.66793015
23LYN1.59892182
24MYLK1.52808899
25BCKDK1.49253690
26KIT1.43241725
27VRK21.39733245
28ARAF1.35986546
29MATK1.33776003
30IKBKB1.33527007
31TRIM281.23647940
32VRK11.23121711
33ZAK1.21306477
34CSF1R1.21024234
35PLK21.20153653
36BMPR1B1.20127767
37LCK1.16537977
38TNK21.14482976
39IRAK41.05773794
40PIK3CA1.05262122
41ACVR1B1.04843384
42HCK0.96204744
43CSNK1G30.92787229
44MAP2K70.90078629
45GRK70.87613498
46PRKCQ0.85650661
47GRK50.85398327
48EPHA30.85078031
49TESK10.84662223
50PIK3CG0.83926536
51BCR0.79822935
52PTK2B0.79104851
53LIMK10.78549086
54TYK20.76416740
55PIM20.74820804
56MAP3K110.70688625
57IKBKE0.69802725
58CDC70.69033499
59MAP2K60.69032767
60WNK40.68809241
61RPS6KA40.68635096
62GRK10.68377091
63FRK0.66431847
64PIM10.64633503
65TBK10.63398356
66CSNK1G20.63223111
67CAMKK20.62733111
68CSNK1G10.61890468
69FLT30.59280211
70JAK30.56577301
71CSNK1A1L0.55601406
72DAPK20.55353579
73RPS6KA50.53707529
74JAK10.51344620
75FYN0.51278373
76MAPK120.48406866
77ADRBK10.47582569
78IGF1R0.47546577
79ILK0.46716083
80DYRK20.43616127
81JAK20.42412775
82WNK30.41319405
83MARK30.40792034
84PRKCE0.40335205
85DAPK10.40170214
86AURKA0.40081637
87CLK10.39061640
88MAPK130.39029056
89PHKG20.38774460
90PHKG10.38774460
91ABL20.37764681
92PKN10.37749459
93OXSR10.37529999
94PRKCD0.34880236
95MAPKAPK20.34318479
96BMX0.34168736
97PRKG10.30658820
98PRKCA0.30318858
99PRKACA0.26652448
100ERBB20.25790763

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.51087368
2Oxidative phosphorylation_Homo sapiens_hsa001903.29789402
3Graft-versus-host disease_Homo sapiens_hsa053323.27720318
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.89968602
5Allograft rejection_Homo sapiens_hsa053302.88554724
6Autoimmune thyroid disease_Homo sapiens_hsa053202.86360107
7Proteasome_Homo sapiens_hsa030502.80260965
8Parkinsons disease_Homo sapiens_hsa050122.57021745
9Asthma_Homo sapiens_hsa053102.48407482
10Antigen processing and presentation_Homo sapiens_hsa046122.33089449
11Type I diabetes mellitus_Homo sapiens_hsa049402.29516451
12Hematopoietic cell lineage_Homo sapiens_hsa046402.14631888
13Homologous recombination_Homo sapiens_hsa034402.08545477
14Protein export_Homo sapiens_hsa030602.05848908
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04662040
16Rheumatoid arthritis_Homo sapiens_hsa053232.03676862
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.99578742
18Alzheimers disease_Homo sapiens_hsa050101.86692980
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80190153
20Ribosome_Homo sapiens_hsa030101.80113563
21Mismatch repair_Homo sapiens_hsa034301.71307878
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66923037
23Huntingtons disease_Homo sapiens_hsa050161.49984339
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.49597026
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.49408916
26Fanconi anemia pathway_Homo sapiens_hsa034601.47914514
27Staphylococcus aureus infection_Homo sapiens_hsa051501.45685731
28Leishmaniasis_Homo sapiens_hsa051401.43882372
29Collecting duct acid secretion_Homo sapiens_hsa049661.42259471
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38647785
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.37428091
32T cell receptor signaling pathway_Homo sapiens_hsa046601.36944382
33Viral myocarditis_Homo sapiens_hsa054161.31424748
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28910416
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28799552
36Nucleotide excision repair_Homo sapiens_hsa034201.27892446
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14653737
38Arachidonic acid metabolism_Homo sapiens_hsa005901.11241339
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.07510173
40DNA replication_Homo sapiens_hsa030301.01588630
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01299037
42Platelet activation_Homo sapiens_hsa046110.99776688
43Cardiac muscle contraction_Homo sapiens_hsa042600.98962981
44Shigellosis_Homo sapiens_hsa051310.97548739
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.95786594
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92598979
47Chemokine signaling pathway_Homo sapiens_hsa040620.90720703
48Salmonella infection_Homo sapiens_hsa051320.89253788
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85871638
50Nitrogen metabolism_Homo sapiens_hsa009100.85824594
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85421016
52Measles_Homo sapiens_hsa051620.84985652
53Chemical carcinogenesis_Homo sapiens_hsa052040.84634555
54Sulfur metabolism_Homo sapiens_hsa009200.84378896
55Phagosome_Homo sapiens_hsa041450.84332257
56Tuberculosis_Homo sapiens_hsa051520.83370504
57Systemic lupus erythematosus_Homo sapiens_hsa053220.81716804
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77969215
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77533420
60Herpes simplex infection_Homo sapiens_hsa051680.74887673
61Osteoclast differentiation_Homo sapiens_hsa043800.74133642
62Linoleic acid metabolism_Homo sapiens_hsa005910.70669477
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66786156
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64068864
65Regulation of autophagy_Homo sapiens_hsa041400.63550038
66Legionellosis_Homo sapiens_hsa051340.61100082
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59923209
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59771352
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.58297091
70Phototransduction_Homo sapiens_hsa047440.57851189
71Pyrimidine metabolism_Homo sapiens_hsa002400.56889243
72African trypanosomiasis_Homo sapiens_hsa051430.56272298
73Olfactory transduction_Homo sapiens_hsa047400.53862504
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53778077
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51460451
76One carbon pool by folate_Homo sapiens_hsa006700.50937648
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50891290
78Malaria_Homo sapiens_hsa051440.50174896
79Morphine addiction_Homo sapiens_hsa050320.49559863
80Basal transcription factors_Homo sapiens_hsa030220.46174212
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45814562
82Base excision repair_Homo sapiens_hsa034100.44229518
83TNF signaling pathway_Homo sapiens_hsa046680.43115300
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42829966
85Toxoplasmosis_Homo sapiens_hsa051450.41567045
86B cell receptor signaling pathway_Homo sapiens_hsa046620.40570063
87RNA degradation_Homo sapiens_hsa030180.40376619
88Pertussis_Homo sapiens_hsa051330.39553708
89Glutathione metabolism_Homo sapiens_hsa004800.39500389
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.35165027
91Purine metabolism_Homo sapiens_hsa002300.33344316
92Epstein-Barr virus infection_Homo sapiens_hsa051690.31866837
93Influenza A_Homo sapiens_hsa051640.31481804
94RNA polymerase_Homo sapiens_hsa030200.30331957
95Endocytosis_Homo sapiens_hsa041440.27092009
96Apoptosis_Homo sapiens_hsa042100.25224141
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.24724023
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24722894
99Caffeine metabolism_Homo sapiens_hsa002320.22361415
100Serotonergic synapse_Homo sapiens_hsa047260.21841789

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