CKAP2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is thought to be a mitotic spindle protein important to neural stem or progenitor cells. Mutations in this gene have been associated with spindle organization defects, including mitotic spindle defects, lagging chromosomes, and chromatin bridges. There is evidence that mutations in this gene are associated with Filippi syndrome, characterized by growth defects, microcephaly, intellectual disability, facial feature defects, and syndactyly. There is a pseudogene of this gene on chromosome 20. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1notochord development (GO:0030903)9.53708127
2histone H2B ubiquitination (GO:0033523)8.04983337
3meiotic chromosome segregation (GO:0045132)7.74617590
4nucleoside transport (GO:0015858)7.12843071
5response to dietary excess (GO:0002021)7.09522932
6nodal signaling pathway (GO:0038092)6.44340859
7inner ear receptor cell development (GO:0060119)6.30830231
8protein autoprocessing (GO:0016540)5.88924363
9regulation of spindle organization (GO:0090224)5.87782529
10negative regulation of telomerase activity (GO:0051974)5.76774735
11autophagic vacuole fusion (GO:0000046)5.74282502
12regulation of centriole replication (GO:0046599)5.67879110
13opioid receptor signaling pathway (GO:0038003)5.65646662
14regulation of telomere maintenance via telomerase (GO:0032210)5.63427307
15nucleotide transport (GO:0006862)5.50384138
16histone mRNA catabolic process (GO:0071044)5.36583411
17microtubule depolymerization (GO:0007019)5.28089926
18mitochondrial genome maintenance (GO:0000002)5.23678160
19DNA ligation (GO:0006266)5.13016221
20regulation of centrosome duplication (GO:0010824)5.07045183
21tooth mineralization (GO:0034505)4.92527305
22spindle checkpoint (GO:0031577)4.92366185
23outer ear morphogenesis (GO:0042473)4.92041724
24regulation of centrosome cycle (GO:0046605)4.90815809
25regulation of secondary heart field cardioblast proliferation (GO:0003266)4.86442571
26regulation of cardioblast proliferation (GO:0003264)4.86442571
27positive regulation of myotube differentiation (GO:0010831)4.83067839
28coronary vasculature morphogenesis (GO:0060977)4.79653335
29chromosome condensation (GO:0030261)4.78971844
30regulation of chromosome segregation (GO:0051983)4.74702214
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.66861878
32nuclear pore complex assembly (GO:0051292)4.60951828
33negative regulation of chromosome segregation (GO:0051985)4.56907242
34mitotic spindle checkpoint (GO:0071174)4.52931548
35histone exchange (GO:0043486)4.51111158
36protein localization to kinetochore (GO:0034501)4.50174344
37negative regulation of mitotic sister chromatid separation (GO:2000816)4.47901351
38negative regulation of sister chromatid segregation (GO:0033046)4.47901351
39negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.47901351
40negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.47901351
41negative regulation of mitotic sister chromatid segregation (GO:0033048)4.47901351
42regulation of mitotic metaphase/anaphase transition (GO:0030071)4.39980356
43regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.39980356
44mitotic spindle assembly checkpoint (GO:0007094)4.37521392
45DNA strand elongation involved in DNA replication (GO:0006271)4.36564980
46protein localization to chromosome (GO:0034502)4.35510821
47positive regulation of chromosome segregation (GO:0051984)4.31728668
48regulation of sister chromatid segregation (GO:0033045)4.31548507
49regulation of mitotic sister chromatid separation (GO:0010965)4.31548507
50regulation of mitotic sister chromatid segregation (GO:0033047)4.31548507
51telomere maintenance via semi-conservative replication (GO:0032201)4.31083665
52DNA replication-independent nucleosome assembly (GO:0006336)4.30489640
53DNA replication-independent nucleosome organization (GO:0034724)4.30489640
54muscle organ morphogenesis (GO:0048644)4.29540540
55organelle membrane fusion (GO:0090174)4.25161923
56DNA strand elongation (GO:0022616)4.23868989
57regulation of helicase activity (GO:0051095)4.20732663
58mitotic sister chromatid cohesion (GO:0007064)4.20527796
59mitotic nuclear envelope disassembly (GO:0007077)4.20498876
60DNA packaging (GO:0006323)4.18847618
61activated T cell proliferation (GO:0050798)4.15945656
62positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.14108488
63positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.14108488
64positive regulation of mitotic sister chromatid separation (GO:1901970)4.14108488
65lymph vessel development (GO:0001945)4.10891421
66mitotic recombination (GO:0006312)4.09675029
67mitotic sister chromatid segregation (GO:0000070)4.06281623
68nuclear pore organization (GO:0006999)4.04733162
69regulation of keratinocyte differentiation (GO:0045616)4.04560632
70megakaryocyte development (GO:0035855)4.04326588
71DNA replication checkpoint (GO:0000076)4.03600478
72metaphase plate congression (GO:0051310)4.02096847
73neural tube development (GO:0021915)3.95664969
74sister chromatid segregation (GO:0000819)3.95251084
75regulation of DNA endoreduplication (GO:0032875)3.93501585
76membrane disassembly (GO:0030397)3.89033205
77nuclear envelope disassembly (GO:0051081)3.89033205
78establishment of integrated proviral latency (GO:0075713)3.88220752
79embryonic viscerocranium morphogenesis (GO:0048703)3.84103714
80protein K6-linked ubiquitination (GO:0085020)3.81507589
81telomere maintenance via recombination (GO:0000722)3.76349276
82cranial nerve morphogenesis (GO:0021602)3.73309029
83protein localization to chromosome, centromeric region (GO:0071459)3.71991579
84negative regulation of telomere maintenance (GO:0032205)3.71952809
85microtubule polymerization or depolymerization (GO:0031109)3.71627736
86histone-serine phosphorylation (GO:0035404)3.66762087
87kinetochore organization (GO:0051383)3.64629477
88reflex (GO:0060004)3.63969148
89regulation of sister chromatid cohesion (GO:0007063)3.63684479
90mitotic G2/M transition checkpoint (GO:0044818)3.62579438
91DNA topological change (GO:0006265)3.61941640
92positive regulation of fibroblast migration (GO:0010763)3.59726480
93outflow tract septum morphogenesis (GO:0003148)3.58517312
94muscle cell fate commitment (GO:0042693)3.58297234
95negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.56128168
96positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.53753565
97negative regulation of mitosis (GO:0045839)3.53644548
98centrosome duplication (GO:0051298)3.53622505
99mitotic spindle organization (GO:0007052)3.53524815
100centriole replication (GO:0007099)3.53256782
101histone monoubiquitination (GO:0010390)3.52686042
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.52162565
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.49010928
104mitotic cell cycle (GO:0000278)3.47267721
105pore complex assembly (GO:0046931)3.46671312
106sensory perception of taste (GO:0050909)3.45252404
107leukocyte cell-cell adhesion (GO:0007159)3.44394517
108detection of mechanical stimulus involved in sensory perception (GO:0050974)3.44375086
109resolution of meiotic recombination intermediates (GO:0000712)3.41915572
110positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.40789313
111establishment of chromosome localization (GO:0051303)3.38424184
112mitotic metaphase plate congression (GO:0007080)3.36499506
113anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35710121
114ATP-dependent chromatin remodeling (GO:0043044)3.35271918
115mismatch repair (GO:0006298)3.33558704
116attachment of spindle microtubules to kinetochore (GO:0008608)3.32360912
117replication fork processing (GO:0031297)3.31746570
118establishment of mitotic spindle localization (GO:0040001)3.31293505
119DNA unwinding involved in DNA replication (GO:0006268)3.29845179
120nucleotide-excision repair, DNA gap filling (GO:0006297)3.29686382
121regulation of establishment of cell polarity (GO:2000114)3.27369773
122chromatin assembly or disassembly (GO:0006333)3.27191587
123mitotic cytokinesis (GO:0000281)3.26866597
124establishment of viral latency (GO:0019043)3.23210097
125detection of molecule of bacterial origin (GO:0032490)3.22513321
126regulation of telomerase activity (GO:0051972)3.21988426
127DNA conformation change (GO:0071103)3.21316432
128mitotic nuclear division (GO:0007067)3.20085790
129negative regulation of cell division (GO:0051782)3.19776303
130ventricular cardiac muscle cell development (GO:0055015)3.18850226
131blastocyst development (GO:0001824)3.16763207
132mitotic chromosome condensation (GO:0007076)3.15879063
133spindle organization (GO:0007051)3.15483414
134chromosome organization (GO:0051276)3.15044756
135DNA replication initiation (GO:0006270)3.14479324
136DNA double-strand break processing (GO:0000729)3.13001915
137double-strand break repair via nonhomologous end joining (GO:0006303)3.12965209
138non-recombinational repair (GO:0000726)3.12965209
139negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.10974916
140centrosome organization (GO:0051297)3.10509815
141mitotic G2 DNA damage checkpoint (GO:0007095)3.10312794
142negative regulation of DNA biosynthetic process (GO:2000279)3.06698702
143negative regulation of nuclear division (GO:0051784)3.06562418
144DNA strand renaturation (GO:0000733)3.05789327
145regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02835750
146regulation of mesenchymal cell apoptotic process (GO:2001053)3.02477188
147platelet formation (GO:0030220)3.01559577
148kinetochore assembly (GO:0051382)2.96792906
149myoblast fusion (GO:0007520)2.96791811
150mRNA polyadenylation (GO:0006378)2.93145147
151chromosome segregation (GO:0007059)2.91326203
152regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87227404
153histone mRNA metabolic process (GO:0008334)2.86379391
154positive regulation of monocyte chemotaxis (GO:0090026)2.86343544
155CENP-A containing nucleosome assembly (GO:0034080)2.85494023
156modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.83232368
157positive regulation by organism of defense response of other organism involved in symbiotic interact2.83232368
158modulation by symbiont of host immune response (GO:0052553)2.83232368
159positive regulation by symbiont of host defense response (GO:0052509)2.83232368
160modulation by symbiont of host defense response (GO:0052031)2.83232368
161modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.83232368
162negative regulation of heart rate (GO:0010459)2.82959091
163glycosylceramide metabolic process (GO:0006677)2.81224476
164spindle assembly involved in mitosis (GO:0090307)2.81110213
165spindle assembly checkpoint (GO:0071173)2.80806565
166chromatin remodeling at centromere (GO:0031055)2.77590882
167regulation of mitotic spindle organization (GO:0060236)2.76654286
168cellular response to vitamin (GO:0071295)2.74015393
169positive regulation of macrophage cytokine production (GO:0060907)2.73411314
170alternative mRNA splicing, via spliceosome (GO:0000380)2.72489457
171reciprocal meiotic recombination (GO:0007131)2.71901245
172reciprocal DNA recombination (GO:0035825)2.71901245
173adenine nucleotide transport (GO:0051503)14.6309120
174purine ribonucleotide transport (GO:0015868)14.4355426
175purine nucleotide transport (GO:0015865)12.7482570

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.06375341
2* FOXM1_23109430_ChIP-Seq_U2OS_Human7.73981538
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse7.17226290
4HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse5.24742573
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.65072909
6IGF1R_20145208_ChIP-Seq_DFB_Human4.33514510
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.28933925
8E2F4_17652178_ChIP-ChIP_JURKAT_Human4.09586268
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.06099646
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.86764358
11SALL1_21062744_ChIP-ChIP_HESCs_Human3.57894927
12ELF1_17652178_ChIP-ChIP_JURKAT_Human3.07719595
13* AR_21909140_ChIP-Seq_LNCAP_Human2.85374283
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.68914848
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62138715
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.46497722
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.38791496
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36819863
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.33523834
20* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32051669
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30181148
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29444421
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.27015242
24KAP1_22055183_ChIP-Seq_ESCs_Mouse2.22243561
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.11899075
26* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05259773
27PCGF2_27294783_Chip-Seq_NPCs_Mouse2.03850677
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01592457
29PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01136279
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00680767
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.95876499
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95587808
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.93339928
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.85853291
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84579243
36DCP1A_22483619_ChIP-Seq_HELA_Human1.84528160
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.83018626
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.75556718
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74068052
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72216039
41XRN2_22483619_ChIP-Seq_HELA_Human1.71422327
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68782509
43FOXP3_21729870_ChIP-Seq_TREG_Human1.68395896
44TTF2_22483619_ChIP-Seq_HELA_Human1.66381816
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64919400
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61514210
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61064420
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60203291
49VDR_23849224_ChIP-Seq_CD4+_Human1.59529336
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54749997
51* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49685796
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48834248
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47624951
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45360779
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42661593
56FUS_26573619_Chip-Seq_HEK293_Human1.41475420
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.41427086
58P53_22127205_ChIP-Seq_FIBROBLAST_Human1.40695084
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.36916647
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35195191
61GABP_19822575_ChIP-Seq_HepG2_Human1.34422570
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34290985
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.34159315
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28116919
65MYC_18940864_ChIP-ChIP_HL60_Human1.28099088
66SCL_19346495_ChIP-Seq_HPC-7_Human1.25716263
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21673279
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21052609
69* KDM2B_26808549_Chip-Seq_REH_Human1.20885731
70* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16735389
71KDM5A_27292631_Chip-Seq_BREAST_Human1.14718467
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11063940
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10164150
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09999991
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09743936
76* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09687210
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08105290
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07711748
79HTT_18923047_ChIP-ChIP_STHdh_Human1.06899327
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.06359380
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05016852
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04605545
83* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04052057
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03160115
85GBX2_23144817_ChIP-Seq_PC3_Human1.02846617
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02083624
87RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01853548
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01546533
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00563120
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99959698
91* P53_22387025_ChIP-Seq_ESCs_Mouse0.98753591
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98638177
93EGR1_19374776_ChIP-ChIP_THP-1_Human0.98299356
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98121568
95* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97295008
96* P300_18555785_Chip-Seq_ESCs_Mouse0.96463154
97TCF4_18268006_ChIP-ChIP_LS174T_Human0.96328663
98* CMYC_18555785_Chip-Seq_ESCs_Mouse0.96044829
99* OCT4_18555785_Chip-Seq_ESCs_Mouse0.95969694
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.95651880
101ELK1_19687146_ChIP-ChIP_HELA_Human0.95379160
102EWS_26573619_Chip-Seq_HEK293_Human0.94849835
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94497827
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91332749
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90162834
106TP53_18474530_ChIP-ChIP_U2OS_Human0.89238900
107FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87181871
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.85443228
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83829076
110* NMYC_18555785_Chip-Seq_ESCs_Mouse0.81921739
111* NANOG_18555785_Chip-Seq_ESCs_Mouse0.81279504
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.80968020
113EZH2_27294783_Chip-Seq_NPCs_Mouse0.80358362
114* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.80164080
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80144285
116SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79410962
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.79117090
118* E2F1_18555785_Chip-Seq_ESCs_Mouse0.78341668
119SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.77700469
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76537597
121IRF8_27001747_Chip-Seq_BMDM_Mouse0.76500192
122* PU1_27457419_Chip-Seq_LIVER_Mouse0.75525157
123* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.75212484
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74843890
125ESET_19884257_ChIP-Seq_ESCs_Mouse0.74778798
126IRF1_19129219_ChIP-ChIP_H3396_Human0.74666819
127* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74205003
128YY1_21170310_ChIP-Seq_MESCs_Mouse0.74011200
129* STAT3_18555785_Chip-Seq_ESCs_Mouse0.73970045
130CIITA_25753668_ChIP-Seq_RAJI_Human0.73826348
131* SOX2_18555785_Chip-Seq_ESCs_Mouse0.71353019
132CRX_20693478_ChIP-Seq_RETINA_Mouse0.71043581
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70833919
134MYC_18555785_ChIP-Seq_MESCs_Mouse0.70742460
135* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.70081321
136NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.69919702
137CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69719399
138KLF4_18555785_ChIP-Seq_MESCs_Mouse0.69354711
139BRD4_27068464_Chip-Seq_AML-cells_Mouse0.69047761
140JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68367332
141ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68135453
142SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.67197062
143EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.66608152
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.66235496
145FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.65812920
146* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.65396076
147CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.65201594
148MYB_21317192_ChIP-Seq_ERMYB_Mouse0.65098688
149VDR_22108803_ChIP-Seq_LS180_Human0.64925815
150KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.64887579
151SOX9_26525672_Chip-Seq_HEART_Mouse0.63941248
152NANOG_16153702_ChIP-ChIP_HESCs_Human0.63926098
153ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.63338289
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.62819753
155TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.62658910
156SOX2_22085726_ChIP-Seq_NPCs_Mouse0.62425955
157VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.62146907
158ZNF274_21170338_ChIP-Seq_K562_Hela0.62096734
159CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.61579144
160SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.61404669
161SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.61404669
162NANOG_21062744_ChIP-ChIP_HESCs_Human0.61398475
163GATA4_25053715_ChIP-Seq_YYC3_Human0.60649118
164TP63_17297297_ChIP-ChIP_HaCaT_Human0.60213220
165HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.59968767
166IRF8_22096565_ChIP-ChIP_GC-B_Human0.59378624
167POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.59358017
168STAT4_19710469_ChIP-ChIP_TH1__Mouse0.58561265
169SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.58376760
170* CTCF_18555785_Chip-Seq_ESCs_Mouse0.57526342
171DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.56735032
172CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.55393099
173GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.55140569
174TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.55056674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology7.93402911
2MP0003693_abnormal_embryo_hatching5.57929125
3MP0000566_synostosis5.17331351
4MP0003136_yellow_coat_color4.37031580
5MP0002234_abnormal_pharynx_morphology4.34373979
6MP0004484_altered_response_of3.45323440
7MP0004036_abnormal_muscle_relaxation3.04808901
8MP0005409_darkened_coat_color3.02063107
9MP0000678_abnormal_parathyroid_gland2.72790131
10MP0003111_abnormal_nucleus_morphology2.53942595
11MP0000343_altered_response_to2.36489860
12MP0002735_abnormal_chemical_nociception2.36083525
13MP0009697_abnormal_copulation2.32440870
14MP0004510_myositis2.26578325
15MP0008932_abnormal_embryonic_tissue2.25897342
16MP0003718_maternal_effect2.24075216
17MP0004957_abnormal_blastocyst_morpholog2.23700206
18MP0010030_abnormal_orbit_morphology2.23206222
19MP0001986_abnormal_taste_sensitivity2.16147623
20MP0003077_abnormal_cell_cycle2.12342800
21MP0006292_abnormal_olfactory_placode2.11262107
22MP0002249_abnormal_larynx_morphology2.01312066
23MP0001727_abnormal_embryo_implantation1.99372258
24MP0010094_abnormal_chromosome_stability1.96390687
25MP0000372_irregular_coat_pigmentation1.94885380
26MP0000490_abnormal_crypts_of1.89693861
27MP0010307_abnormal_tumor_latency1.86876221
28MP0003950_abnormal_plasma_membrane1.74869986
29MP0001697_abnormal_embryo_size1.73338729
30MP0008057_abnormal_DNA_replication1.72803955
31MP0001730_embryonic_growth_arrest1.71434853
32MP0002938_white_spotting1.67679195
33MP0003786_premature_aging1.64093710
34MP0003937_abnormal_limbs/digits/tail_de1.59393697
35MP0002168_other_aberrant_phenotype1.56091998
36MP0002085_abnormal_embryonic_tissue1.50962755
37MP0004808_abnormal_hematopoietic_stem1.49511223
38MP0000579_abnormal_nail_morphology1.48677409
39MP0003890_abnormal_embryonic-extraembry1.45317761
40MP0008877_abnormal_DNA_methylation1.43954309
41MP0002080_prenatal_lethality1.41576746
42MP0003787_abnormal_imprinting1.38622696
43MP0002084_abnormal_developmental_patter1.38341978
44MP0002877_abnormal_melanocyte_morpholog1.34553588
45MP0001545_abnormal_hematopoietic_system1.33541185
46MP0005397_hematopoietic_system_phenotyp1.33541185
47MP0000681_abnormal_thyroid_gland1.33181832
48MP0009278_abnormal_bone_marrow1.30212505
49MP0000733_abnormal_muscle_development1.28047537
50MP0000015_abnormal_ear_pigmentation1.24963385
51MP0000762_abnormal_tongue_morphology1.23618146
52MP0001286_abnormal_eye_development1.21195159
53MP0010352_gastrointestinal_tract_polyps1.21184782
54MP0002697_abnormal_eye_size1.16371439
55MP0005171_absent_coat_pigmentation1.11868607
56MP0009764_decreased_sensitivity_to1.09940777
57MP0001346_abnormal_lacrimal_gland1.08282163
58MP0004147_increased_porphyrin_level1.07099734
59MP0003755_abnormal_palate_morphology1.06623124
60MP0008789_abnormal_olfactory_epithelium1.05573282
61MP0001293_anophthalmia1.05445571
62MP0006072_abnormal_retinal_apoptosis1.04609788
63MP0000427_abnormal_hair_cycle1.04585798
64MP0002233_abnormal_nose_morphology1.01451797
65MP0009785_altered_susceptibility_to1.00439155
66MP0000049_abnormal_middle_ear0.98670102
67MP0001270_distended_abdomen0.97378921
68MP0001853_heart_inflammation0.97246765
69MP0009672_abnormal_birth_weight0.96756749
70MP0003566_abnormal_cell_adhesion0.96710333
71MP0001790_abnormal_immune_system0.96366986
72MP0005387_immune_system_phenotype0.96366986
73MP0002086_abnormal_extraembryonic_tissu0.96219693
74MP0000467_abnormal_esophagus_morphology0.96079048
75MP0002095_abnormal_skin_pigmentation0.95286296
76MP0002019_abnormal_tumor_incidence0.95157924
77MP0000428_abnormal_craniofacial_morphol0.94884774
78MP0003122_maternal_imprinting0.94796655
79MP0000358_abnormal_cell_content/0.92512556
80MP0002210_abnormal_sex_determination0.92007787
81MP0008058_abnormal_DNA_repair0.91159099
82MP0001529_abnormal_vocalization0.90893077
83MP0002396_abnormal_hematopoietic_system0.89885820
84MP0005076_abnormal_cell_differentiation0.89770560
85MP0003806_abnormal_nucleotide_metabolis0.88372061
86MP0001835_abnormal_antigen_presentation0.87999951
87MP0005360_urolithiasis0.87829936
88MP0009053_abnormal_anal_canal0.86540473
89MP0006082_CNS_inflammation0.85577219
90MP0001879_abnormal_lymphatic_vessel0.84428791
91MP0003861_abnormal_nervous_system0.83450328
92MP0003567_abnormal_fetal_cardiomyocyte0.82514927
93MP0004197_abnormal_fetal_growth/weight/0.82449969
94MP0000647_abnormal_sebaceous_gland0.82407376
95MP0001963_abnormal_hearing_physiology0.82029284
96MP0006035_abnormal_mitochondrial_morpho0.81147950
97MP0002089_abnormal_postnatal_growth/wei0.80576740
98MP0005408_hypopigmentation0.80509970
99MP0002092_abnormal_eye_morphology0.80377628
100MP0001800_abnormal_humoral_immune0.80018162
101MP0003935_abnormal_craniofacial_develop0.79258418
102MP0003705_abnormal_hypodermis_morpholog0.77413864
103MP0000383_abnormal_hair_follicle0.75369925
104MP0003315_abnormal_perineum_morphology0.75134549
105MP0002452_abnormal_antigen_presenting0.74179239
106MP0009703_decreased_birth_body0.73744736
107MP0002723_abnormal_immune_serum0.73734461
108MP0001672_abnormal_embryogenesis/_devel0.73711059
109MP0005380_embryogenesis_phenotype0.73711059
110MP0003943_abnormal_hepatobiliary_system0.72791812
111MP0002932_abnormal_joint_morphology0.72192721
112MP0003984_embryonic_growth_retardation0.72179614
113MP0000432_abnormal_head_morphology0.72024959
114MP0003698_abnormal_male_reproductive0.71658399
115MP0009250_abnormal_appendicular_skeleto0.71568585
116MP0002282_abnormal_trachea_morphology0.71451430
117MP0002177_abnormal_outer_ear0.70805795
118MP0003385_abnormal_body_wall0.70619061
119MP0003699_abnormal_female_reproductive0.70471717
120MP0001968_abnormal_touch/_nociception0.69452215
121MP0000703_abnormal_thymus_morphology0.67818459
122MP0002088_abnormal_embryonic_growth/wei0.67616572
123MP0002160_abnormal_reproductive_system0.67522137
124MP0000313_abnormal_cell_death0.66930215
125MP0005391_vision/eye_phenotype0.66133792
126MP0005395_other_phenotype0.65322023
127MP0005499_abnormal_olfactory_system0.65151116
128MP0005394_taste/olfaction_phenotype0.65151116
129MP0003121_genomic_imprinting0.65085277
130MP0002161_abnormal_fertility/fecundity0.64459101
131MP0001119_abnormal_female_reproductive0.63969719
132MP0000350_abnormal_cell_proliferation0.63468562
133MP0000767_abnormal_smooth_muscle0.63388030
134MP0001299_abnormal_eye_distance/0.62067472
135MP0003119_abnormal_digestive_system0.61536996
136MP0005623_abnormal_meninges_morphology0.60621982
137MP0003045_fibrosis0.60619115
138MP0002111_abnormal_tail_morphology0.60199312
139MP0000653_abnormal_sex_gland0.60159315
140MP0003123_paternal_imprinting0.59927307
141MP0008007_abnormal_cellular_replicative0.59925058
142MP0000537_abnormal_urethra_morphology0.59473720
143MP0005384_cellular_phenotype0.59291294
144MP0003091_abnormal_cell_migration0.59134435
145MP0005025_abnormal_response_to0.58406443
146MP0003941_abnormal_skin_development0.58371185
147MP0002722_abnormal_immune_system0.58316619
148MP0001145_abnormal_male_reproductive0.57664198
149MP0000689_abnormal_spleen_morphology0.56754576
150MP0005197_abnormal_uvea_morphology0.55383416
151MP0000026_abnormal_inner_ear0.54198962
152MP0001929_abnormal_gametogenesis0.53065776
153MP0005167_abnormal_blood-brain_barrier0.52964862
154MP0001819_abnormal_immune_cell0.52558358
155MP0003453_abnormal_keratinocyte_physiol0.51832299
156MP0002419_abnormal_innate_immunity0.51507441
157MP0002075_abnormal_coat/hair_pigmentati0.51186543
158MP0002398_abnormal_bone_marrow0.50815544

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)6.04402277
2Panhypogammaglobulinemia (HP:0003139)5.90488523
3Tetany (HP:0001281)5.81189194
4Spastic paraparesis (HP:0002313)5.37924944
5Double outlet right ventricle (HP:0001719)5.13441566
6Congenital malformation of the right heart (HP:0011723)5.13441566
7Abnormality of the aortic arch (HP:0012303)4.83248931
8Elfin facies (HP:0004428)4.70350398
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.54991611
10Meckel diverticulum (HP:0002245)4.44250111
11Abnormality of T cell physiology (HP:0011840)4.26441003
12Aplasia/Hypoplasia of the uvula (HP:0010293)4.25119085
13Abnormality of chromosome stability (HP:0003220)4.24483964
14Small intestinal stenosis (HP:0012848)4.23395988
15Duodenal stenosis (HP:0100867)4.23395988
16Abnormality of the ileum (HP:0001549)4.22980868
17Overriding aorta (HP:0002623)4.17669544
18Abnormal lung lobation (HP:0002101)4.09867126
19Abnormality of the preputium (HP:0100587)4.02299072
20Volvulus (HP:0002580)3.96477993
21Recurrent viral infections (HP:0004429)3.87695020
22Chronic mucocutaneous candidiasis (HP:0002728)3.87201688
23Recurrent cutaneous fungal infections (HP:0011370)3.87201688
24Nephroblastoma (Wilms tumor) (HP:0002667)3.63982548
25Hypoplasia of the fovea (HP:0007750)3.56881172
26Aplasia/Hypoplasia of the fovea (HP:0008060)3.56881172
27Abnormality of the duodenum (HP:0002246)3.56195667
28Distal lower limb amyotrophy (HP:0008944)3.52581907
29Embryonal renal neoplasm (HP:0011794)3.51166132
30Abnormality of the parathyroid morphology (HP:0011766)3.50091688
31Upper limb muscle weakness (HP:0003484)3.44119307
32Viral hepatitis (HP:0006562)3.41761426
33Recurrent fungal infections (HP:0002841)3.39705106
34Myelodysplasia (HP:0002863)3.34890749
35Cortical dysplasia (HP:0002539)3.29622092
36Sloping forehead (HP:0000340)3.26125369
37Abnormality of chromosome segregation (HP:0002916)3.18671654
38Birth length less than 3rd percentile (HP:0003561)3.16296468
39Renovascular hypertension (HP:0100817)3.15885750
40Ectopic kidney (HP:0000086)3.15114669
41Abnormality of the carotid arteries (HP:0005344)3.14342849
42Distal lower limb muscle weakness (HP:0009053)3.13264953
43Hyperacusis (HP:0010780)3.12159991
44Renal duplication (HP:0000075)3.10844948
45Agammaglobulinemia (HP:0004432)3.08385525
46Hyperthyroidism (HP:0000836)3.05832896
47Hypoplastic left heart (HP:0004383)3.01445613
48Paraparesis (HP:0002385)2.99903621
49Patellar dislocation (HP:0002999)2.98101340
50Colitis (HP:0002583)2.97672599
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90582338
52Abnormality of T cells (HP:0002843)2.89313987
53Broad metatarsal (HP:0001783)2.78885044
54Absent radius (HP:0003974)2.71429966
55Insomnia (HP:0100785)2.69325468
56Chronic obstructive pulmonary disease (HP:0006510)2.68235214
57Obstructive lung disease (HP:0006536)2.68235214
58Clubbing of toes (HP:0100760)2.62826187
59Reticulocytopenia (HP:0001896)2.62772362
60Abnormality of the labia minora (HP:0012880)2.61049967
61Autoimmune thrombocytopenia (HP:0001973)2.60254808
62Lower limb amyotrophy (HP:0007210)2.60037754
63Hypoparathyroidism (HP:0000829)2.55890701
64Absent forearm bone (HP:0003953)2.54379199
65Aplasia involving forearm bones (HP:0009822)2.54379199
66Abnormality of the fovea (HP:0000493)2.51751493
67Flat cornea (HP:0007720)2.51617558
68Cafe-au-lait spot (HP:0000957)2.51487300
69Abnormal ventriculo-arterial connection (HP:0011563)2.50973831
70Transposition of the great arteries (HP:0001669)2.50973831
71Abnormal connection of the cardiac segments (HP:0011545)2.50973831
72Cholelithiasis (HP:0001081)2.48808293
73Triphalangeal thumb (HP:0001199)2.47431792
74Seborrheic dermatitis (HP:0001051)2.47226005
75Rhabdomyosarcoma (HP:0002859)2.44936598
76Increased nuchal translucency (HP:0010880)2.44864106
77Abnormality of the diencephalon (HP:0010662)2.43074859
78Horseshoe kidney (HP:0000085)2.42384423
79Partial duplication of thumb phalanx (HP:0009944)2.42241674
80Abnormal sex determination (HP:0012244)2.36827404
81Sex reversal (HP:0012245)2.36827404
82Abnormality of small intestinal villus morphology (HP:0011472)2.33559091
83Villous atrophy (HP:0011473)2.33559091
84Vertebral arch anomaly (HP:0008438)2.32667775
85Aplasia/Hypoplasia of the sternum (HP:0006714)2.32408879
86Aplasia/Hypoplasia of the macula (HP:0008059)2.30106000
87Colon cancer (HP:0003003)2.29449288
88Abnormality of the tricuspid valve (HP:0001702)2.29138736
89Duplicated collecting system (HP:0000081)2.28628540
90Embryonal neoplasm (HP:0002898)2.28536543
91Neoplasm of the colon (HP:0100273)2.26164251
92Partial duplication of the phalanx of hand (HP:0009999)2.25441345
93Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24626393
94Hypoplastic heart (HP:0001961)2.24471754
95Arteriovenous malformation (HP:0100026)2.23966898
96Patellar aplasia (HP:0006443)2.22069082
97Renal dysplasia (HP:0000110)2.18679653
98Aplasia/Hypoplasia of the earlobes (HP:0009906)2.18039528
99Mesomelia (HP:0003027)2.17922686
100Hypertensive crisis (HP:0100735)2.17883141
101Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17197461
102Hypoplastic pelvis (HP:0008839)2.17036055
103Absent thumb (HP:0009777)2.15697198
104Chromsome breakage (HP:0040012)2.14244323
105Abnormal gallbladder morphology (HP:0012437)2.14051487
106Inflammation of the large intestine (HP:0002037)2.13772846
107Delusions (HP:0000746)2.10162226
108High pitched voice (HP:0001620)2.08983048
109Rib fusion (HP:0000902)2.08071482
110Abnormal number of incisors (HP:0011064)2.07626201
111Aplasia/Hypoplasia of the patella (HP:0006498)2.06360663
112Gastrointestinal inflammation (HP:0004386)2.05866204
113Breast hypoplasia (HP:0003187)2.05180415
114Small hand (HP:0200055)2.03956132
115Short thumb (HP:0009778)2.03915371
116Duplication of thumb phalanx (HP:0009942)2.03590169
117Posterior embryotoxon (HP:0000627)2.03326144
118Shallow orbits (HP:0000586)2.00818160
119Truncus arteriosus (HP:0001660)2.00474916
120Amblyopia (HP:0000646)1.98554142
121Asymmetric septal hypertrophy (HP:0001670)1.98063438
122Abnormality of the renal collecting system (HP:0004742)1.97992148
123Porencephaly (HP:0002132)1.96844421
124Recurrent skin infections (HP:0001581)1.96003391
125Ependymoma (HP:0002888)1.95930542
126Exotropia (HP:0000577)1.95902123
127Choanal atresia (HP:0000453)1.95809519
128Abnormality of homocysteine metabolism (HP:0010919)1.95602749
129Homocystinuria (HP:0002156)1.95602749
130Aplasia/Hypoplasia of the thymus (HP:0010515)1.94837548
131Short palpebral fissure (HP:0012745)1.94274909
132Proximal placement of thumb (HP:0009623)1.92214981
133Pelvic girdle muscle weakness (HP:0003749)1.91472876
134Aplasia/Hypoplasia affecting the retina (HP:0008061)1.91231287
135Abnormality of the proximal phalanges of the hand (HP:0009834)1.91204464
136Supernumerary spleens (HP:0009799)1.90535540
137Hypoplasia of the pons (HP:0012110)1.89576435
138Absent epiphyses (HP:0010577)1.89368761
139Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89368761
140Long clavicles (HP:0000890)1.88819925
141Abnormality of the line of Schwalbe (HP:0008048)1.88516702
142Carpal bone hypoplasia (HP:0001498)1.88385616
143Facial hemangioma (HP:0000329)1.88087646
144Obsessive-compulsive behavior (HP:0000722)1.87259323
145Abnormality of DNA repair (HP:0003254)1.85806132
146Deep philtrum (HP:0002002)1.84409277
147Preauricular pit (HP:0004467)1.84075854
148Periauricular skin pits (HP:0100277)1.84075854
149Progressive sensorineural hearing impairment (HP:0000408)1.83910707
150Glioma (HP:0009733)1.83025827
151Squamous cell carcinoma (HP:0002860)1.82382611
152Abnormality of the pons (HP:0007361)1.82185929
153Overlapping toe (HP:0001845)1.81216210
154Small epiphyses (HP:0010585)1.80472399
155Holoprosencephaly (HP:0001360)1.79119601
156Abnormality of lateral ventricle (HP:0030047)1.78827182
157Deviation of the thumb (HP:0009603)1.78812139
15811 pairs of ribs (HP:0000878)1.78028774
159Missing ribs (HP:0000921)1.77978641
160Amaurosis fugax (HP:0100576)1.77949023
161Abnormality of methionine metabolism (HP:0010901)1.77192877
162Medulloblastoma (HP:0002885)1.76112283
163Bone marrow hypocellularity (HP:0005528)1.75541472
164Ulnar bowing (HP:0003031)1.75398524
165Oligodactyly (hands) (HP:0001180)1.74278627
166Cleft eyelid (HP:0000625)1.73194314
167Conical tooth (HP:0000698)1.72918243
168Abnormality of the fetal cardiovascular system (HP:0010948)1.72644589
169Abnormal umbilical cord blood vessels (HP:0011403)1.72644589
170Single umbilical artery (HP:0001195)1.72644589
171Chronic otitis media (HP:0000389)1.72584243
172Dandy-Walker malformation (HP:0001305)1.70635516
173Astigmatism (HP:0000483)1.68789413
174Abnormality of the septum pellucidum (HP:0007375)1.64445927
175Oligodactyly (HP:0012165)1.60082597
176Irregular epiphyses (HP:0010582)1.59863874
177Absent septum pellucidum (HP:0001331)1.57774461
178Abnormality of the astrocytes (HP:0100707)1.57214602
179Astrocytoma (HP:0009592)1.57214602
180Tracheoesophageal fistula (HP:0002575)1.56339261
181Abnormality of the anterior horn cell (HP:0006802)1.55989964
182Degeneration of anterior horn cells (HP:0002398)1.55989964
183Broad distal phalanx of finger (HP:0009836)1.55727424
184Abnormal auditory evoked potentials (HP:0006958)1.55696094
185Ovarian neoplasm (HP:0100615)1.54585931
186Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.54343963
187Hypopigmentation of the fundus (HP:0007894)1.54114328
188Oligohydramnios (HP:0001562)1.52990131
189Abnormality of the umbilical cord (HP:0010881)1.52377448
190High anterior hairline (HP:0009890)1.52341398
191Intestinal polyposis (HP:0200008)1.51676895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST46.09341901
2OBSCN4.79065251
3IRAK34.37053311
4NTRK13.87315816
5RPS6KA43.28094776
6BUB13.21580042
7PRPF4B3.00364471
8WEE12.88683204
9PBK2.65056457
10STK42.56499421
11BRSK22.17216568
12TAOK22.15509267
13EIF2AK22.09805066
14CDC71.93013937
15IKBKE1.87984248
16TBK11.87463043
17VRK21.86481320
18FGFR21.82495518
19CAMK1D1.81826735
20PIM11.80069225
21BRSK11.79190886
22MKNK21.79146901
23NTRK21.75104103
24TTK1.67852811
25IRAK41.66158491
26WNK31.59430633
27PLK11.49897221
28EIF2AK31.48898956
29PAK31.48484333
30NEK21.47279086
31TSSK61.44802773
32ADRBK21.42021293
33TRIM281.38906712
34TAF11.34307070
35BRAF1.20789983
36PNCK1.20683521
37NUAK11.20149664
38AURKB1.15507991
39CAMK1G1.10701426
40KIT1.06938336
41EEF2K1.04571037
42STK101.01684320
43PAK61.00097888
44MAP3K140.99591695
45NEK10.95769340
46RPS6KA50.94874189
47LATS10.92443725
48ATM0.84491929
49CDK80.81501685
50SRPK10.80203933
51IKBKB0.79137208
52STK160.77538256
53CCNB10.77318474
54PLK30.73554026
55CAMKK10.72832780
56PLK20.71130213
57MKNK10.70376386
58MARK30.69915724
59NTRK30.69835548
60BCR0.68972078
61CHEK20.68565641
62AKT20.67787631
63MAP3K80.67745864
64MELK0.64307287
65ERBB40.64032056
66BMX0.62895774
67CDK40.62635548
68CAMK40.62436404
69TXK0.62113397
70CHEK10.61931065
71CSNK1E0.61274851
72ATR0.59892729
73CDK60.57966748
74ERBB30.57702451
75SGK10.56330611
76ALK0.56236170
77PIM20.55639511
78NME20.55593447
79LATS20.55184267
80CDK10.54298586
81RPS6KA60.53881088
82AKT10.53545555
83CDK120.53187917
84EIF2AK10.51943737
85BTK0.50075027
86BMPR1B0.49930162
87MET0.49124713
88ZAK0.48870614
89STK30.48633668
90AURKA0.47821948
91RPS6KB20.47231680
92TTN0.44581387
93CDK180.44193648
94PLK40.44128422
95UHMK10.43720484
96CLK10.41713778
97MAP3K70.40533678
98CDK90.40351066
99CDK150.40133592
100DAPK30.40014537
101CDK70.39122476
102CDK11A0.38907250
103EGFR0.38463052
104PRKCI0.38428717
105CHUK0.37706978
106TNIK0.36723247
107PASK0.36656163
108NME10.34466198
109STK38L0.34426114
110CDK20.34376545
111CDK140.32720467
112PAK10.32588288
113PAK40.32196266
114CDK30.31857334
115PKN20.31697291
116MAPK140.31514380
117MINK10.30054286
118RPS6KB10.29425970
119JAK10.29234100
120PRKACB0.28792511
121TLK10.28198679
122CSNK2A20.28072323
123SCYL20.27736341
124MAP4K10.26821359
125FGFR10.26783356
126PRKDC0.26314953
127VRK10.26234460
128SIK30.25523175
129MAP3K100.25184889
130PDK10.24644118
131MAPK10.23179146
132MST1R0.23108527
133CSNK1D0.22670669
134NEK90.22332567
135DYRK30.21130307
136PDK20.20918805
137CSNK2A10.20503474
138BRD40.18800571
139KSR10.18425965
140STK390.18317038
141ACVR1B0.17981792
142SMG10.16644629
143WNK40.15998943
144PKN10.14936187
145CSNK1G10.13566173

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034104.46697796
2DNA replication_Homo sapiens_hsa030303.80840574
3Cell cycle_Homo sapiens_hsa041102.75271855
4Primary immunodeficiency_Homo sapiens_hsa053402.65436159
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.46920188
6Mismatch repair_Homo sapiens_hsa034302.40443487
7One carbon pool by folate_Homo sapiens_hsa006702.33580320
8Homologous recombination_Homo sapiens_hsa034402.23646721
9Herpes simplex infection_Homo sapiens_hsa051682.21201631
10Fanconi anemia pathway_Homo sapiens_hsa034602.14998612
11RNA polymerase_Homo sapiens_hsa030202.07022783
12PPAR signaling pathway_Homo sapiens_hsa033202.02097178
13SNARE interactions in vesicular transport_Homo sapiens_hsa041301.96126835
14Taste transduction_Homo sapiens_hsa047421.95818934
15Leishmaniasis_Homo sapiens_hsa051401.93453134
16Protein export_Homo sapiens_hsa030601.80335106
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78857915
18RNA degradation_Homo sapiens_hsa030181.78825837
19Ribosome_Homo sapiens_hsa030101.76285564
20Vitamin digestion and absorption_Homo sapiens_hsa049771.75634507
21Notch signaling pathway_Homo sapiens_hsa043301.68709502
22Small cell lung cancer_Homo sapiens_hsa052221.64347608
23Antigen processing and presentation_Homo sapiens_hsa046121.61291444
24Phagosome_Homo sapiens_hsa041451.57778155
25Apoptosis_Homo sapiens_hsa042101.55163334
26mRNA surveillance pathway_Homo sapiens_hsa030151.50737215
27Viral carcinogenesis_Homo sapiens_hsa052031.47444517
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.45007927
29Tuberculosis_Homo sapiens_hsa051521.41685226
30Chronic myeloid leukemia_Homo sapiens_hsa052201.40864846
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.40749263
32Epstein-Barr virus infection_Homo sapiens_hsa051691.40351238
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39329775
34B cell receptor signaling pathway_Homo sapiens_hsa046621.37740966
35p53 signaling pathway_Homo sapiens_hsa041151.35871734
36Oocyte meiosis_Homo sapiens_hsa041141.33307005
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30796065
38TNF signaling pathway_Homo sapiens_hsa046681.27537573
39Hepatitis B_Homo sapiens_hsa051611.26572178
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.23934131
41HTLV-I infection_Homo sapiens_hsa051661.21672699
42Spliceosome_Homo sapiens_hsa030401.21306742
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20729728
44Systemic lupus erythematosus_Homo sapiens_hsa053221.18163496
45RNA transport_Homo sapiens_hsa030131.14780303
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14523886
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09592527
48Purine metabolism_Homo sapiens_hsa002301.06746543
49Measles_Homo sapiens_hsa051621.06629095
50Non-homologous end-joining_Homo sapiens_hsa034501.04739801
51Legionellosis_Homo sapiens_hsa051341.04334520
52Hematopoietic cell lineage_Homo sapiens_hsa046401.02398602
53Malaria_Homo sapiens_hsa051441.02209496
54Focal adhesion_Homo sapiens_hsa045101.00011228
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99761416
56Pyruvate metabolism_Homo sapiens_hsa006200.99755150
57Shigellosis_Homo sapiens_hsa051310.96792697
58Biosynthesis of amino acids_Homo sapiens_hsa012300.96609150
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95687063
60Selenocompound metabolism_Homo sapiens_hsa004500.94976938
61Prostate cancer_Homo sapiens_hsa052150.93073797
62Folate biosynthesis_Homo sapiens_hsa007900.92162773
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89872415
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87286569
65Huntingtons disease_Homo sapiens_hsa050160.86763066
66Nucleotide excision repair_Homo sapiens_hsa034200.85560433
67Fatty acid biosynthesis_Homo sapiens_hsa000610.85178374
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83846283
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83311962
70Parkinsons disease_Homo sapiens_hsa050120.83251615
71Basal transcription factors_Homo sapiens_hsa030220.82479111
72Hippo signaling pathway_Homo sapiens_hsa043900.78412099
73MicroRNAs in cancer_Homo sapiens_hsa052060.77563532
74ECM-receptor interaction_Homo sapiens_hsa045120.76731669
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.74645879
76Lysine degradation_Homo sapiens_hsa003100.74430956
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73826045
78T cell receptor signaling pathway_Homo sapiens_hsa046600.71397686
79Estrogen signaling pathway_Homo sapiens_hsa049150.71284793
80Tryptophan metabolism_Homo sapiens_hsa003800.71279265
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70285184
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70005927
83Glioma_Homo sapiens_hsa052140.69169239
84Chemokine signaling pathway_Homo sapiens_hsa040620.69046149
85beta-Alanine metabolism_Homo sapiens_hsa004100.68906784
86Oxidative phosphorylation_Homo sapiens_hsa001900.68677131
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67817222
88Vitamin B6 metabolism_Homo sapiens_hsa007500.66104117
89Carbon metabolism_Homo sapiens_hsa012000.65504432
90Glutathione metabolism_Homo sapiens_hsa004800.65258621
91ABC transporters_Homo sapiens_hsa020100.64814681
92Prion diseases_Homo sapiens_hsa050200.64662813
93Basal cell carcinoma_Homo sapiens_hsa052170.64507609
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.64149633
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63088624
96Fatty acid elongation_Homo sapiens_hsa000620.60556997
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59333836
98TGF-beta signaling pathway_Homo sapiens_hsa043500.58492066
99N-Glycan biosynthesis_Homo sapiens_hsa005100.58428595
100Amoebiasis_Homo sapiens_hsa051460.57852835
101Platelet activation_Homo sapiens_hsa046110.57584391
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57542590
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55629324
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55259241
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55054128
106Thyroid cancer_Homo sapiens_hsa052160.53997928
107Propanoate metabolism_Homo sapiens_hsa006400.52250962
108Prolactin signaling pathway_Homo sapiens_hsa049170.51929977
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51429756
110Histidine metabolism_Homo sapiens_hsa003400.51170768
111Proteasome_Homo sapiens_hsa030500.49246701
112Glucagon signaling pathway_Homo sapiens_hsa049220.47992898
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47935170
114Pyrimidine metabolism_Homo sapiens_hsa002400.47448166
115Proteoglycans in cancer_Homo sapiens_hsa052050.46495044
116Salmonella infection_Homo sapiens_hsa051320.46169201
117Fatty acid degradation_Homo sapiens_hsa000710.45797585
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.45350042
119Adherens junction_Homo sapiens_hsa045200.45131303
120Hedgehog signaling pathway_Homo sapiens_hsa043400.44916769
121Colorectal cancer_Homo sapiens_hsa052100.44466229
122Fructose and mannose metabolism_Homo sapiens_hsa000510.44392540
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43786265
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43783013
125Sulfur relay system_Homo sapiens_hsa041220.43501782
126Staphylococcus aureus infection_Homo sapiens_hsa051500.42401672
127Wnt signaling pathway_Homo sapiens_hsa043100.41842909
128Amphetamine addiction_Homo sapiens_hsa050310.40534139
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.40110426
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39782842
131Axon guidance_Homo sapiens_hsa043600.38875247
132Steroid biosynthesis_Homo sapiens_hsa001000.37625406
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37080501
134Cocaine addiction_Homo sapiens_hsa050300.35479367
135Alzheimers disease_Homo sapiens_hsa050100.34762306
136Rheumatoid arthritis_Homo sapiens_hsa053230.34704163
137Alcoholism_Homo sapiens_hsa050340.34494166
138Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34284874
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34270957
140Metabolic pathways_Homo sapiens_hsa011000.34145603
141Osteoclast differentiation_Homo sapiens_hsa043800.34114405
142Toxoplasmosis_Homo sapiens_hsa051450.33564150
143Phenylalanine metabolism_Homo sapiens_hsa003600.32549778
144Pentose phosphate pathway_Homo sapiens_hsa000300.32537432
145Melanoma_Homo sapiens_hsa052180.32328160
146Bladder cancer_Homo sapiens_hsa052190.25631914
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25092905
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23382786
149Pancreatic cancer_Homo sapiens_hsa052120.20308780
150Fatty acid metabolism_Homo sapiens_hsa012120.19487737
151Pathways in cancer_Homo sapiens_hsa052000.19123349
152Drug metabolism - other enzymes_Homo sapiens_hsa009830.18756314
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.14495391
154Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.14001467
155Phototransduction_Homo sapiens_hsa047440.07635949
156Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07563299
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06920189
158PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05985693

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