CISD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007 [PubMed 17376863]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.37476531
2respiratory electron transport chain (GO:0022904)5.80907812
3electron transport chain (GO:0022900)5.68370153
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.60881026
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.45558198
6ATP synthesis coupled proton transport (GO:0015986)5.45558198
7L-phenylalanine metabolic process (GO:0006558)4.83926532
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.83926532
9L-phenylalanine catabolic process (GO:0006559)4.71505064
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.71505064
11aldehyde catabolic process (GO:0046185)4.37472796
12negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.19005184
13protein maturation by protein folding (GO:0022417)3.99725543
14NADH metabolic process (GO:0006734)3.89766481
15protein complex biogenesis (GO:0070271)3.89579281
16aromatic amino acid family catabolic process (GO:0009074)3.76604915
17respiratory chain complex IV assembly (GO:0008535)3.76402569
18alkaloid metabolic process (GO:0009820)3.75719888
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.68533964
20NADH dehydrogenase complex assembly (GO:0010257)3.68533964
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68533964
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.66696233
23mitochondrial respiratory chain complex assembly (GO:0033108)3.58537660
24cellular response to zinc ion (GO:0071294)3.48822499
25omega-hydroxylase P450 pathway (GO:0097267)3.47041051
26flavonoid metabolic process (GO:0009812)3.42718798
27regulation of cellular amino acid metabolic process (GO:0006521)3.39737556
28cytochrome complex assembly (GO:0017004)3.39118538
29cellular ketone body metabolic process (GO:0046950)3.36989400
30oxidative phosphorylation (GO:0006119)3.34090551
31inner mitochondrial membrane organization (GO:0007007)3.33415043
32ribosomal small subunit biogenesis (GO:0042274)3.32547298
33viral transcription (GO:0019083)3.30433026
34ATP biosynthetic process (GO:0006754)3.28279764
35purine nucleoside triphosphate biosynthetic process (GO:0009145)3.27328249
36purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.25242546
37hydrogen ion transmembrane transport (GO:1902600)3.22706668
38uronic acid metabolic process (GO:0006063)3.22622004
39glucuronate metabolic process (GO:0019585)3.22622004
40glutathione biosynthetic process (GO:0006750)3.22139065
41short-chain fatty acid metabolic process (GO:0046459)3.21654853
42chaperone-mediated protein transport (GO:0072321)3.20793484
43aromatic amino acid family metabolic process (GO:0009072)3.17782215
44GTP biosynthetic process (GO:0006183)3.14612284
45regulation of cholesterol esterification (GO:0010872)3.13592809
46positive regulation of cellular amine metabolic process (GO:0033240)3.09284021
47translational termination (GO:0006415)3.08529461
48tyrosine metabolic process (GO:0006570)3.07252189
49glyoxylate metabolic process (GO:0046487)3.05145183
50cotranslational protein targeting to membrane (GO:0006613)3.04087028
51oxaloacetate metabolic process (GO:0006107)3.03461231
52coenzyme catabolic process (GO:0009109)3.03367580
53aerobic respiration (GO:0009060)3.02289423
54nonribosomal peptide biosynthetic process (GO:0019184)3.02107158
55fatty acid catabolic process (GO:0009062)3.02004817
56protein targeting to mitochondrion (GO:0006626)3.01635414
57fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.01363290
58SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.99857556
59protein targeting to ER (GO:0045047)2.98920360
60tryptophan catabolic process (GO:0006569)2.97615166
61indole-containing compound catabolic process (GO:0042436)2.97615166
62indolalkylamine catabolic process (GO:0046218)2.97615166
63proton transport (GO:0015992)2.97609965
64dopamine transport (GO:0015872)2.96270946
65hydrogen transport (GO:0006818)2.93524557
66establishment of protein localization to mitochondrion (GO:0072655)2.92860675
67ketone body metabolic process (GO:1902224)2.92855224
68sulfur amino acid catabolic process (GO:0000098)2.92712436
69protein localization to endoplasmic reticulum (GO:0070972)2.92346634
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91522697
71urea metabolic process (GO:0019627)2.90326487
72urea cycle (GO:0000050)2.90326487
73bile acid biosynthetic process (GO:0006699)2.89853345
74proline biosynthetic process (GO:0006561)2.89709364
75fatty acid beta-oxidation (GO:0006635)2.87854707
76nitrogen cycle metabolic process (GO:0071941)2.87843416
77fat-soluble vitamin biosynthetic process (GO:0042362)2.87805866
78triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.87489056
79daunorubicin metabolic process (GO:0044597)2.86769407
80polyketide metabolic process (GO:0030638)2.86769407
81doxorubicin metabolic process (GO:0044598)2.86769407
82vitamin biosynthetic process (GO:0009110)2.86686813
83protein neddylation (GO:0045116)2.86402989
84cysteine metabolic process (GO:0006534)2.86282078
85water-soluble vitamin biosynthetic process (GO:0042364)2.85567760
86regulation of mitochondrial translation (GO:0070129)2.85388763
87proteasome assembly (GO:0043248)2.84333855
88cellular glucuronidation (GO:0052695)2.83802376
89monocarboxylic acid catabolic process (GO:0072329)2.83717145
90serine family amino acid catabolic process (GO:0009071)2.83231156
91establishment of protein localization to mitochondrial membrane (GO:0090151)2.82852736
92ethanol oxidation (GO:0006069)2.82849037
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.82764063
94ribonucleoside triphosphate biosynthetic process (GO:0009201)2.82126560
95GDP-mannose metabolic process (GO:0019673)2.81935372
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.80268350
97quinone biosynthetic process (GO:1901663)2.80259445
98ubiquinone biosynthetic process (GO:0006744)2.80259445
99nucleobase-containing small molecule interconversion (GO:0015949)2.79058780
100branched-chain amino acid catabolic process (GO:0009083)2.78101513
101arginine metabolic process (GO:0006525)2.77982671
102fructose metabolic process (GO:0006000)2.77797319
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76612010
104negative regulation of ligase activity (GO:0051352)2.76612010
105mitochondrial transport (GO:0006839)2.75068146
106cofactor catabolic process (GO:0051187)2.74786954
107positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.74664008
108peptidyl-glutamic acid carboxylation (GO:0017187)2.73203899
109protein carboxylation (GO:0018214)2.73203899
110glutathione derivative biosynthetic process (GO:1901687)2.72253148
111glutathione derivative metabolic process (GO:1901685)2.72253148
112tryptophan metabolic process (GO:0006568)2.72202018
113DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72003518
114carboxylic acid catabolic process (GO:0046395)2.70941422
115organic acid catabolic process (GO:0016054)2.70941422
116positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70938559
117epoxygenase P450 pathway (GO:0019373)2.69275374
118fatty acid oxidation (GO:0019395)2.68399341
119amine catabolic process (GO:0009310)2.68197470
120cellular biogenic amine catabolic process (GO:0042402)2.68197470
121termination of RNA polymerase III transcription (GO:0006386)2.68003179
122transcription elongation from RNA polymerase III promoter (GO:0006385)2.68003179
123response to nitrosative stress (GO:0051409)2.67906802
124regulation of triglyceride catabolic process (GO:0010896)2.67794207
125ethanol metabolic process (GO:0006067)2.67775958
126NAD biosynthetic process (GO:0009435)2.67718262
127protein localization to mitochondrion (GO:0070585)2.67323934
128antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.67150536
129nucleoside diphosphate biosynthetic process (GO:0009133)2.65952106
130lipid oxidation (GO:0034440)2.65845348
131kynurenine metabolic process (GO:0070189)2.65214044
132arginine catabolic process (GO:0006527)2.64852069
133bile acid and bile salt transport (GO:0015721)2.64184176
134alpha-amino acid catabolic process (GO:1901606)2.62979305
135intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.61356021
136signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.61356021
137mitochondrial calcium ion transport (GO:0006851)2.61255114
138regulation of cellular amine metabolic process (GO:0033238)2.60537116
139regulation of oxidative phosphorylation (GO:0002082)2.58556387
140cellular amino acid catabolic process (GO:0009063)2.58152470
141cellular response to cadmium ion (GO:0071276)2.57896890
142glutathione metabolic process (GO:0006749)2.57150437
143signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.55369741
144signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.55369741
145signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.55369741
146nuclear envelope reassembly (GO:0031468)2.53639186
147mitotic nuclear envelope reassembly (GO:0007084)2.53639186
148signal transduction involved in DNA damage checkpoint (GO:0072422)2.51781030
149signal transduction involved in DNA integrity checkpoint (GO:0072401)2.51781030
150proline metabolic process (GO:0006560)2.50928075
151positive regulation of lipoprotein lipase activity (GO:0051006)2.48694144
152positive regulation of triglyceride lipase activity (GO:0061365)2.48694144
153aminoglycoside antibiotic metabolic process (GO:0030647)2.48688678
1542-deoxyribonucleotide biosynthetic process (GO:0009265)2.48353853
155deoxyribose phosphate biosynthetic process (GO:0046385)2.48353853
156angiotensin maturation (GO:0002003)2.48222516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.11403842
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.91383094
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.07347809
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.79995152
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.58898375
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.53013157
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.39090415
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19638239
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.18664618
10PPARA_22158963_ChIP-Seq_LIVER_Mouse3.00577372
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.36850038
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35228754
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.35215222
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.33823220
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.28775174
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.27043308
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26776959
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.20045968
19ZNF263_19887448_ChIP-Seq_K562_Human2.13684565
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09384323
21LXR_22292898_ChIP-Seq_THP-1_Human2.09362085
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95614074
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95097798
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.89517823
25TET1_21451524_ChIP-Seq_MESCs_Mouse1.85501188
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.84293752
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81258639
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77602019
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77541044
30SRY_22984422_ChIP-ChIP_TESTIS_Rat1.76753677
31* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.73996083
32* RACK7_27058665_Chip-Seq_MCF-7_Human1.73578901
33XRN2_22483619_ChIP-Seq_HELA_Human1.71533408
34VDR_21846776_ChIP-Seq_THP-1_Human1.68438652
35TAF15_26573619_Chip-Seq_HEK293_Human1.63963914
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60575163
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60038742
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55295170
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.54820958
40GABP_19822575_ChIP-Seq_HepG2_Human1.54163984
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53933546
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53320935
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52823012
44P68_20966046_ChIP-Seq_HELA_Human1.50461071
45BCL6_27268052_Chip-Seq_Bcells_Human1.49473890
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.46600698
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.45335518
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43913372
49EZH2_22144423_ChIP-Seq_EOC_Human1.41827164
50BCOR_27268052_Chip-Seq_Bcells_Human1.39088557
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38721990
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.38702496
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34742031
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32242669
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29876987
56RAD21_21589869_ChIP-Seq_MESCs_Mouse1.29011157
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28087640
58CTCF_26484167_Chip-Seq_Bcells_Mouse1.27742708
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27428825
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.26852503
61SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25106096
62DCP1A_22483619_ChIP-Seq_HELA_Human1.23767190
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23588024
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22975701
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20397118
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.20193076
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.19446449
68* SA1_27219007_Chip-Seq_ERYTHROID_Human1.19065662
69E2F1_20622854_ChIP-Seq_HELA_Human1.18533736
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18069946
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17295161
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.17198020
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16603486
74* FOXP1_21924763_ChIP-Seq_HESCs_Human1.16567146
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16093509
76PHF8_20622854_ChIP-Seq_HELA_Human1.15711620
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14889242
78STAT1_20625510_ChIP-Seq_HELA_Human1.14880137
79VDR_22108803_ChIP-Seq_LS180_Human1.14778962
80* SA1_27219007_Chip-Seq_Bcells_Human1.14666717
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14360178
82NANOG_20526341_ChIP-Seq_ESCs_Human1.14241260
83IRF1_19129219_ChIP-ChIP_H3396_Human1.14054123
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13761878
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.13248759
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11429029
87TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08933843
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08831509
89RARB_24833708_ChIP-Seq_LIVER_Mouse1.07833658
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07710621
91CTCF_20526341_ChIP-Seq_ESCs_Human1.07231145
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07122756
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06910991
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06878937
95ATF3_27146783_Chip-Seq_COLON_Human1.06698820
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06243149
97CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05841580
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.05684208
99CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05063429
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04992066
101* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04885905
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03807683
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03621423
104TTF2_22483619_ChIP-Seq_HELA_Human1.03221033
105KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03169080
106KDM5A_27292631_Chip-Seq_BREAST_Human1.02198536
107PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01603961
108AR_20517297_ChIP-Seq_VCAP_Human1.01518586
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01507043
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01210072
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99479162
112HTT_18923047_ChIP-ChIP_STHdh_Human0.99441248
113FLI1_27457419_Chip-Seq_LIVER_Mouse0.98921600
114BP1_19119308_ChIP-ChIP_Hs578T_Human0.97554044
115TRIM28_21343339_ChIP-Seq_HEK293_Human0.96610076
116SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96244102
117EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95933454
118RARA_24833708_ChIP-Seq_LIVER_Mouse0.95727353
119MYC_18555785_ChIP-Seq_MESCs_Mouse0.95505565
120CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95370468
121GBX2_23144817_ChIP-Seq_PC3_Human0.95254202
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95032234
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90768936
124SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88981362
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87955649
126KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87121796
127KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87121796
128KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87121796
129YY1_22570637_ChIP-Seq_MALME-3M_Human0.87105713
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87052358
131ERG_20517297_ChIP-Seq_VCAP_Human0.87040114
132GATA3_21867929_ChIP-Seq_CD8_Mouse0.86584574
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86461040
134THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85235911
135PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85068077
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84268650
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82103122
138NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.81650578
139EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.80956347
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80869875
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79961798
142MYC_18940864_ChIP-ChIP_HL60_Human0.79298155
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78947137
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78635101
145SOX2_20726797_ChIP-Seq_SW620_Human0.78585279
146SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75582335
147NFE2_27457419_Chip-Seq_LIVER_Mouse0.74428330
148RUNX1_27457419_Chip-Seq_LIVER_Mouse0.73556495
149POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73159006
150SOX2_22085726_ChIP-Seq_NPCs_Mouse0.73124832
151* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72626084
152NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72600130
153FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72025623
154FOXA1_25329375_ChIP-Seq_VCAP_Human0.72025623
155* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.70238070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.50376269
2MP0005360_urolithiasis4.83393885
3MP0009379_abnormal_foot_pigmentation4.28851448
4MP0003806_abnormal_nucleotide_metabolis3.97574310
5MP0005085_abnormal_gallbladder_physiolo3.89063965
6MP0008875_abnormal_xenobiotic_pharmacok3.43514307
7MP0005058_abnormal_lysosome_morphology3.30859087
8MP0005365_abnormal_bile_salt2.96463275
9MP0003195_calcinosis2.46213663
10MP0003136_yellow_coat_color2.34913167
11MP0005332_abnormal_amino_acid2.34788596
12MP0006036_abnormal_mitochondrial_physio2.33761418
13MP0010234_abnormal_vibrissa_follicle2.32083910
14MP0006276_abnormal_autonomic_nervous2.25983002
15MP0003724_increased_susceptibility_to2.24069218
16MP0002876_abnormal_thyroid_physiology2.15210487
17MP0002822_catalepsy2.14637123
18MP0005083_abnormal_biliary_tract2.04748322
19MP0003868_abnormal_feces_composition1.94478607
20MP0009333_abnormal_splenocyte_physiolog1.88631910
21MP0001666_abnormal_nutrient_absorption1.87368185
22MP0003186_abnormal_redox_activity1.83680262
23MP0003252_abnormal_bile_duct1.82014952
24MP0001529_abnormal_vocalization1.79552098
25MP0001188_hyperpigmentation1.79253313
26MP0005409_darkened_coat_color1.78507894
27MP0005084_abnormal_gallbladder_morpholo1.74203015
28MP0000678_abnormal_parathyroid_gland1.71338089
29MP0001986_abnormal_taste_sensitivity1.71008209
30MP0003880_abnormal_central_pattern1.69589243
31MP0001873_stomach_inflammation1.68898412
32MP0003011_delayed_dark_adaptation1.61819256
33MP0010329_abnormal_lipoprotein_level1.61789684
34MP0001905_abnormal_dopamine_level1.61187958
35MP0004019_abnormal_vitamin_homeostasis1.55438344
36MP0001764_abnormal_homeostasis1.53691005
37MP0000372_irregular_coat_pigmentation1.51611616
38MP0003075_altered_response_to1.49205988
39MP0009840_abnormal_foam_cell1.44185763
40MP0004142_abnormal_muscle_tone1.43971933
41MP0001756_abnormal_urination1.40565450
42MP0005584_abnormal_enzyme/coenzyme_acti1.40301416
43MP0001968_abnormal_touch/_nociception1.39902516
44MP0002837_dystrophic_cardiac_calcinosis1.38761001
45MP0009697_abnormal_copulation1.36715425
46MP0006035_abnormal_mitochondrial_morpho1.36712203
47MP0001853_heart_inflammation1.35885531
48MP0001661_extended_life_span1.35278902
49MP0002736_abnormal_nociception_after1.35122141
50MP0005330_cardiomyopathy1.34720397
51MP0004858_abnormal_nervous_system1.34082362
52MP0004381_abnormal_hair_follicle1.32668164
53MP0002138_abnormal_hepatobiliary_system1.31220048
54MP0003646_muscle_fatigue1.31067677
55MP0002877_abnormal_melanocyte_morpholog1.30476009
56MP0004043_abnormal_pH_regulation1.24785363
57MP0009643_abnormal_urine_homeostasis1.23802877
58MP0005636_abnormal_mineral_homeostasis1.23325995
59MP0002118_abnormal_lipid_homeostasis1.22134807
60MP0005319_abnormal_enzyme/_coenzyme1.19405621
61MP0003123_paternal_imprinting1.18848693
62MP0000343_altered_response_to1.17404304
63MP0002735_abnormal_chemical_nociception1.17046759
64MP0001664_abnormal_digestion1.16626561
65MP0005166_decreased_susceptibility_to1.16337692
66MP0005535_abnormal_body_temperature1.15795960
67MP0003172_abnormal_lysosome_physiology1.09259573
68MP0001881_abnormal_mammary_gland1.08231865
69MP0005408_hypopigmentation1.08024368
70MP0000858_altered_metastatic_potential1.06734675
71MP0008872_abnormal_physiological_respon1.04654199
72MP0002733_abnormal_thermal_nociception1.03739112
73MP0002796_impaired_skin_barrier1.03720640
74MP0003866_abnormal_defecation1.02989822
75MP0005501_abnormal_skin_physiology1.02202397
76MP0010386_abnormal_urinary_bladder1.02105826
77MP0000490_abnormal_crypts_of1.00890679
78MP0005379_endocrine/exocrine_gland_phen0.99702347
79MP0001970_abnormal_pain_threshold0.98706350
80MP0010155_abnormal_intestine_physiology0.97304782
81MP0004147_increased_porphyrin_level0.97226644
82MP0002638_abnormal_pupillary_reflex0.96327459
83MP0005266_abnormal_metabolism0.96299513
84MP0001663_abnormal_digestive_system0.96082612
85MP0002132_abnormal_respiratory_system0.95487890
86MP0000609_abnormal_liver_physiology0.94882468
87MP0001765_abnormal_ion_homeostasis0.94263361
88MP0004510_myositis0.93806189
89MP0005451_abnormal_body_composition0.93079620
90MP0006082_CNS_inflammation0.91822576
91MP0000681_abnormal_thyroid_gland0.90059260
92MP0009785_altered_susceptibility_to0.89588711
93MP0001845_abnormal_inflammatory_respons0.89311066
94MP0005376_homeostasis/metabolism_phenot0.88738709
95MP0004185_abnormal_adipocyte_glucose0.88107033
96MP0002277_abnormal_respiratory_mucosa0.87938132
97MP0001440_abnormal_grooming_behavior0.85631684
98MP0003786_premature_aging0.85506847
99MP0005381_digestive/alimentary_phenotyp0.84097360
100MP0002734_abnormal_mechanical_nocicepti0.83203803
101MP0002751_abnormal_autonomic_nervous0.83002173
102MP0002160_abnormal_reproductive_system0.82798734
103MP0003638_abnormal_response/metabolism_0.81335412
104MP0003718_maternal_effect0.80566075
105MP0000749_muscle_degeneration0.80327348
106MP0005025_abnormal_response_to0.80212974
107MP0002272_abnormal_nervous_system0.79147730
108MP0002136_abnormal_kidney_physiology0.78082492
109MP0003879_abnormal_hair_cell0.77320416
110MP0005666_abnormal_adipose_tissue0.76994958
111MP0000230_abnormal_systemic_arterial0.75959043
112MP0000538_abnormal_urinary_bladder0.75636404
113MP0008469_abnormal_protein_level0.75258079
114MP0002163_abnormal_gland_morphology0.74948319
115MP0003693_abnormal_embryo_hatching0.73698404
116MP0008004_abnormal_stomach_pH0.72062241
117MP0002693_abnormal_pancreas_physiology0.71479499
118MP0000747_muscle_weakness0.71431733
119MP0008007_abnormal_cellular_replicative0.70607723
120MP0006292_abnormal_olfactory_placode0.70212902
121MP0000613_abnormal_salivary_gland0.69901101
122MP0002067_abnormal_sensory_capabilities0.68920520
123MP0005257_abnormal_intraocular_pressure0.68463308
124MP0002078_abnormal_glucose_homeostasis0.68186311
125MP0005670_abnormal_white_adipose0.67923815
126MP0003315_abnormal_perineum_morphology0.67099383
127MP0005375_adipose_tissue_phenotype0.66763156
128MP0002148_abnormal_hypersensitivity_rea0.66319269
129MP0009765_abnormal_xenobiotic_induced0.66220595
130MP0005464_abnormal_platelet_physiology0.65703869
131MP0009642_abnormal_blood_homeostasis0.65510320
132MP0004742_abnormal_vestibular_system0.65299440
133MP0001944_abnormal_pancreas_morphology0.65178120
134MP0000751_myopathy0.64745808
135MP0005075_abnormal_melanosome_morpholog0.64480037
136MP0003959_abnormal_lean_body0.64340184
137MP0003191_abnormal_cellular_cholesterol0.64287085
138MP0008260_abnormal_autophagy0.64160932
139MP0002909_abnormal_adrenal_gland0.63974795
140MP0002970_abnormal_white_adipose0.63840252
141MP0009764_decreased_sensitivity_to0.63801269
142MP0002971_abnormal_brown_adipose0.63446057
143MP0003436_decreased_susceptibility_to0.63105724
144MP0005165_increased_susceptibility_to0.61446323
145MP0005551_abnormal_eye_electrophysiolog0.60219127
146MP0003953_abnormal_hormone_level0.59943566
147MP0002229_neurodegeneration0.59823227
148MP0002332_abnormal_exercise_endurance0.59601636

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.31416907
2Mitochondrial inheritance (HP:0001427)4.99636219
3Acute encephalopathy (HP:0006846)4.98590276
4Abnormal mitochondria in muscle tissue (HP:0008316)4.89029949
5Hepatocellular necrosis (HP:0001404)4.86305077
6Hepatic necrosis (HP:0002605)4.77052989
7Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.39558681
8Progressive macrocephaly (HP:0004481)4.37416066
9Increased CSF lactate (HP:0002490)4.34319865
10Cerebral edema (HP:0002181)4.34249616
11Abnormality of aromatic amino acid family metabolism (HP:0004338)4.31490771
12Lipid accumulation in hepatocytes (HP:0006561)4.11428940
13Increased hepatocellular lipid droplets (HP:0006565)4.07611322
14Renal Fanconi syndrome (HP:0001994)3.92070436
15Increased intramyocellular lipid droplets (HP:0012240)3.76763537
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.75768354
17Increased muscle lipid content (HP:0009058)3.69129387
183-Methylglutaconic aciduria (HP:0003535)3.63958520
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.51710039
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.51710039
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.45077074
22Systemic lupus erythematosus (HP:0002725)3.45058480
23Lethargy (HP:0001254)3.39332659
24Optic disc pallor (HP:0000543)3.34896294
25Lactic acidosis (HP:0003128)3.34219616
26Dicarboxylic aciduria (HP:0003215)3.20399487
27Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20399487
28Hypothermia (HP:0002045)3.15534394
29Hyperglycinemia (HP:0002154)3.12676331
30Hyperglycinuria (HP:0003108)3.11885221
31Respiratory failure (HP:0002878)3.11095431
32Exercise intolerance (HP:0003546)3.10527191
33Prolonged partial thromboplastin time (HP:0003645)3.07745402
34Increased serum lactate (HP:0002151)3.05321579
35Abnormality of liposaccharide metabolism (HP:0010968)3.02905353
36Abnormality of glycosphingolipid metabolism (HP:0004343)3.02905353
37Abnormality of glycolipid metabolism (HP:0010969)3.02905353
38Glycosuria (HP:0003076)2.96135166
39Abnormality of urine glucose concentration (HP:0011016)2.96135166
40Intrahepatic cholestasis (HP:0001406)2.94170447
41Testicular atrophy (HP:0000029)2.92115498
42Exertional dyspnea (HP:0002875)2.87298986
43Hyperphosphaturia (HP:0003109)2.85613243
44Abnormality of serine family amino acid metabolism (HP:0010894)2.77028413
45Abnormality of glycine metabolism (HP:0010895)2.77028413
46Abnormality of renal resorption (HP:0011038)2.75202307
47Hyperammonemia (HP:0001987)2.72119008
48Reduced antithrombin III activity (HP:0001976)2.63870496
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.62039514
50Hypobetalipoproteinemia (HP:0003563)2.53821278
51Vacuolated lymphocytes (HP:0001922)2.51519681
52Leukodystrophy (HP:0002415)2.50178716
53Type I transferrin isoform profile (HP:0003642)2.48925777
54Axonal loss (HP:0003447)2.47910606
55Abnormal urine phosphate concentration (HP:0012599)2.45351090
56Methylmalonic aciduria (HP:0012120)2.44309309
57Abnormality of glycolysis (HP:0004366)2.43853243
58Increased serum pyruvate (HP:0003542)2.43853243
59Abnormality of fatty-acid metabolism (HP:0004359)2.41061750
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40943430
61Opisthotonus (HP:0002179)2.40806599
62Vomiting (HP:0002013)2.38184650
63Vertebral compression fractures (HP:0002953)2.37299045
64Abnormality of serum amino acid levels (HP:0003112)2.35959197
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35427477
66Complement deficiency (HP:0004431)2.34037292
67Abnormal hemoglobin (HP:0011902)2.34004844
68Xanthomatosis (HP:0000991)2.26990567
69Abnormal pupillary function (HP:0007686)2.26527046
70Ketosis (HP:0001946)2.25982502
71Methylmalonic acidemia (HP:0002912)2.25868969
72Microvesicular hepatic steatosis (HP:0001414)2.25611947
73Abnormality of complement system (HP:0005339)2.25372172
74Abnormality of pyrimidine metabolism (HP:0004353)2.24269023
75Hypokinesia (HP:0002375)2.24215645
76Progressive external ophthalmoplegia (HP:0000590)2.23780496
77Sensory axonal neuropathy (HP:0003390)2.23304605
78CNS demyelination (HP:0007305)2.22553346
79Deep venous thrombosis (HP:0002625)2.20657675
80Generalized aminoaciduria (HP:0002909)2.20161702
81Progressive neurologic deterioration (HP:0002344)2.18856615
82Late onset (HP:0003584)2.18485545
83Metabolic acidosis (HP:0001942)2.17761164
84Conjugated hyperbilirubinemia (HP:0002908)2.17526275
85Hypoglycemic coma (HP:0001325)2.16805413
86Petechiae (HP:0000967)2.14846983
87Abnormality of methionine metabolism (HP:0010901)2.14782896
88Neuroendocrine neoplasm (HP:0100634)2.10952258
89Microretrognathia (HP:0000308)2.10627441
90Pheochromocytoma (HP:0002666)2.09937510
91Ileus (HP:0002595)2.09905965
92Macrocytic anemia (HP:0001972)2.07393994
93Prolonged neonatal jaundice (HP:0006579)2.05941832
94Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.05706164
95Gout (HP:0001997)2.04019761
96Malnutrition (HP:0004395)2.02651444
97Rough bone trabeculation (HP:0100670)2.00446096
98Emotional lability (HP:0000712)1.99834148
99Vascular calcification (HP:0004934)1.99829437
100Ragged-red muscle fibers (HP:0003200)1.97758814
101Renal tubular dysfunction (HP:0000124)1.96724656
102Joint hemorrhage (HP:0005261)1.96635971
103Alkalosis (HP:0001948)1.96375175
104Respiratory difficulties (HP:0002880)1.96125877
105Abnormal trabecular bone morphology (HP:0100671)1.95063747
106Dysostosis multiplex (HP:0000943)1.93295862
107Hydroxyprolinuria (HP:0003080)1.92139828
108Abnormality of proline metabolism (HP:0010907)1.92139828
109Abnormality of cells of the erythroid lineage (HP:0012130)1.91484424
110Neoplasm of head and neck (HP:0012288)1.90693729
111Esophageal neoplasm (HP:0100751)1.90693729
112Glomerulonephritis (HP:0000099)1.90314153
113Abnormality of magnesium homeostasis (HP:0004921)1.90012649
114Fat malabsorption (HP:0002630)1.89277095
115Paraparesis (HP:0002385)1.89195872
116Purpura (HP:0000979)1.88352900
117X-linked dominant inheritance (HP:0001423)1.86377930
118Nausea (HP:0002018)1.86163805
119Rhabdomyolysis (HP:0003201)1.85800964
120Palpitations (HP:0001962)1.85609086
121Abnormality of polysaccharide metabolism (HP:0011012)1.84902588
122Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84902588
123Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84902588
124Hyperlipoproteinemia (HP:0010980)1.82395603
125Abnormality of the vitamin B12 metabolism (HP:0004341)1.82373631
126Ketoacidosis (HP:0001993)1.82345211
127Delayed CNS myelination (HP:0002188)1.81046537
128Abnormality of vitamin B metabolism (HP:0004340)1.80543562
129Abnormal number of erythroid precursors (HP:0012131)1.79903063
130Abnormality of vitamin metabolism (HP:0100508)1.79754949
131Spastic paraparesis (HP:0002313)1.77904183
132Hyperbilirubinemia (HP:0002904)1.74427493
133Amniotic constriction ring (HP:0009775)1.73432771
134Abnormality of placental membranes (HP:0011409)1.73432771
135Proximal tubulopathy (HP:0000114)1.72740606
136Abnormal gallbladder physiology (HP:0012438)1.72490828
137Cholecystitis (HP:0001082)1.72490828
138Pancreatitis (HP:0001733)1.72155285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.67058947
2VRK24.06446325
3CASK3.69492512
4TNIK3.42002470
5BCKDK3.29996999
6TLK13.23683136
7ERN12.86865852
8EPHA22.66354308
9STK162.59248755
10MAP3K122.48344317
11NME12.38426327
12MUSK2.30746673
13STK392.21704691
14IRAK32.06999471
15MST42.01241706
16MYLK1.93681909
17MAPKAPK31.88752417
18PIM21.85278648
19ARAF1.84814964
20PBK1.83619233
21WNK41.70021333
22ILK1.68250421
23GRK71.67150775
24TRIB31.63566240
25MST1R1.60564372
26ADRBK21.57744459
27PAK41.50879828
28GRK51.50192797
29OXSR11.48404176
30TESK21.43828077
31TAOK21.38311975
32MKNK21.37688915
33EIF2AK31.33513502
34PRKCI1.31724515
35IRAK11.30987569
36SIK11.30473627
37MAPKAPK51.25149828
38DAPK11.23998972
39MAP2K21.23772865
40CDK191.23114079
41TAOK11.22314251
42MAP2K61.21026063
43IRAK41.20292717
44PRKD31.19353283
45MAP3K31.17391655
46PIK3CG1.14773811
47MAP2K71.13410085
48SMG11.10488499
49NLK1.10008929
50FES1.09521961
51PINK11.07581596
52MAPK151.06661617
53PIK3CA1.06005823
54EIF2AK11.04421359
55BRAF1.02852594
56MAP3K111.02663416
57BLK0.99164759
58PRKG20.98729724
59TEC0.98645278
60IRAK20.97360389
61LIMK10.96824859
62CAMK2D0.96027797
63OBSCN0.95565190
64ABL20.91893347
65CAMK2G0.90259786
66LRRK20.89715661
67CAMK2B0.84010189
68SCYL20.83882437
69PDK20.82801406
70BMPR1B0.80294628
71BRSK10.80286064
72VRK10.79474279
73PRKD20.76009067
74LMTK20.72858214
75DAPK30.69055101
76BMPR20.68252476
77EPHB20.67709011
78CSNK1G30.67384079
79ADRBK10.62737063
80SRPK10.62722892
81RPS6KB20.62277439
82MAPK110.60337148
83CSNK1G10.59806050
84MAP4K10.59754761
85NEK10.58689039
86TBK10.58578574
87MAPK40.57995281
88PTK20.57860193
89CDK80.56987800
90CAMK2A0.56714249
91AURKA0.56376587
92YES10.54359361
93TYK20.54224836
94ERBB40.53651892
95PAK10.52954358
96AKT30.52633168
97PRKACA0.52376720
98MAP3K10.51674855
99MAP2K40.51587501
100PDPK10.50926876
101PHKG10.50366398
102PHKG20.50366398
103MAPK130.49903115
104CAMKK20.48574124
105FLT30.48325860
106KDR0.48310415
107TXK0.48202474
108CDK70.47618265
109CSK0.47416111
110BUB10.47144581
111MAP2K30.46782641
112MAP3K80.46223673
113GRK10.45288135
114TGFBR20.44112439
115PTK60.43294991
116NEK90.43262482
117IKBKB0.42092943
118PKN10.41508294
119TESK10.40864830
120ZAP700.40607296
121PRKAA20.38552315
122GRK60.38364046
123TIE10.38305408
124CSNK2A10.37192980
125INSRR0.36413989
126IKBKE0.35068418
127MAPK120.34687181
128CSNK2A20.34528806
129CLK10.33219598
130RPS6KA50.33098526
131PRKCE0.32078372
132CSNK1A1L0.31836007
133MATK0.31676965
134MET0.31550025
135UHMK10.30894251
136PRKCA0.30647144
137TNK20.30594237
138MKNK10.29534431
139MAPKAPK20.25374029
140CSNK1G20.24947750
141AURKB0.24337848
142CDK11A0.23622522
143CSNK1A10.23599615
144PRKCD0.23141321
145PRKD10.23061927
146PKN20.21059336
147MOS0.18992427
148DMPK0.17837199
149STK100.17700427
150BMX0.16753476

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.25762914
2Parkinsons disease_Homo sapiens_hsa050123.57437117
3Ribosome_Homo sapiens_hsa030102.83438482
4Alzheimers disease_Homo sapiens_hsa050102.59550760
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.42559514
6Sulfur metabolism_Homo sapiens_hsa009202.38609634
7Huntingtons disease_Homo sapiens_hsa050162.31870228
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25240889
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17833200
10Fatty acid elongation_Homo sapiens_hsa000622.17462507
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.08743509
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07376703
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.02724882
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.02672874
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95599525
16Histidine metabolism_Homo sapiens_hsa003401.93638706
17Propanoate metabolism_Homo sapiens_hsa006401.91363075
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91267767
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85504672
20Fatty acid degradation_Homo sapiens_hsa000711.84807258
21Protein export_Homo sapiens_hsa030601.83534828
22Tryptophan metabolism_Homo sapiens_hsa003801.81166661
23Butanoate metabolism_Homo sapiens_hsa006501.76418345
24Peroxisome_Homo sapiens_hsa041461.76367349
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69287730
26Pyruvate metabolism_Homo sapiens_hsa006201.68803514
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67265472
28Folate biosynthesis_Homo sapiens_hsa007901.59426263
29Chemical carcinogenesis_Homo sapiens_hsa052041.56021456
30Tyrosine metabolism_Homo sapiens_hsa003501.54083098
31Sulfur relay system_Homo sapiens_hsa041221.52198039
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.46087233
33Cardiac muscle contraction_Homo sapiens_hsa042601.41309247
34Vitamin B6 metabolism_Homo sapiens_hsa007501.40775457
35Arginine biosynthesis_Homo sapiens_hsa002201.40633818
36Phenylalanine metabolism_Homo sapiens_hsa003601.31006687
37Steroid biosynthesis_Homo sapiens_hsa001001.30392490
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29221158
39Proteasome_Homo sapiens_hsa030501.27592679
40Retinol metabolism_Homo sapiens_hsa008301.24659596
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.22905081
42beta-Alanine metabolism_Homo sapiens_hsa004101.21160479
43Glutathione metabolism_Homo sapiens_hsa004801.20043562
44Fatty acid metabolism_Homo sapiens_hsa012121.19488999
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.18732522
46Carbon metabolism_Homo sapiens_hsa012001.18712854
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17608985
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14711544
49Arginine and proline metabolism_Homo sapiens_hsa003301.14392155
50Fat digestion and absorption_Homo sapiens_hsa049751.12628751
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12038513
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.11803675
53DNA replication_Homo sapiens_hsa030301.11668783
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11355027
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08002853
56Starch and sucrose metabolism_Homo sapiens_hsa005001.06982625
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06941035
58Metabolic pathways_Homo sapiens_hsa011001.03857850
59PPAR signaling pathway_Homo sapiens_hsa033201.00893365
60Base excision repair_Homo sapiens_hsa034100.99511599
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.96335817
62Complement and coagulation cascades_Homo sapiens_hsa046100.92645664
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92540509
64Arachidonic acid metabolism_Homo sapiens_hsa005900.87802941
65Lysosome_Homo sapiens_hsa041420.87174949
66Linoleic acid metabolism_Homo sapiens_hsa005910.84218639
67RNA polymerase_Homo sapiens_hsa030200.81081946
68Fructose and mannose metabolism_Homo sapiens_hsa000510.77200449
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76162946
70Renin-angiotensin system_Homo sapiens_hsa046140.75943993
71Pentose phosphate pathway_Homo sapiens_hsa000300.75895182
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74265451
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72305533
74Prion diseases_Homo sapiens_hsa050200.71581426
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.68578713
76Vitamin digestion and absorption_Homo sapiens_hsa049770.67256014
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65516577
78Pyrimidine metabolism_Homo sapiens_hsa002400.65423560
79Biosynthesis of amino acids_Homo sapiens_hsa012300.64675865
80Ether lipid metabolism_Homo sapiens_hsa005650.59355753
81N-Glycan biosynthesis_Homo sapiens_hsa005100.58610174
82Galactose metabolism_Homo sapiens_hsa000520.58031979
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56456293
84Mismatch repair_Homo sapiens_hsa034300.56298000
85One carbon pool by folate_Homo sapiens_hsa006700.56081263
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55717436
87Caffeine metabolism_Homo sapiens_hsa002320.54829192
88Collecting duct acid secretion_Homo sapiens_hsa049660.54823830
89Glycerolipid metabolism_Homo sapiens_hsa005610.54745221
90Nucleotide excision repair_Homo sapiens_hsa034200.49771814
91Bile secretion_Homo sapiens_hsa049760.49163911
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48954771
93Other glycan degradation_Homo sapiens_hsa005110.47662231
94Staphylococcus aureus infection_Homo sapiens_hsa051500.47488465
95ABC transporters_Homo sapiens_hsa020100.42572813
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42306212
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41670468
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40927280
99Vibrio cholerae infection_Homo sapiens_hsa051100.38433512
100Purine metabolism_Homo sapiens_hsa002300.34244643
101Regulation of autophagy_Homo sapiens_hsa041400.33738752
102Nitrogen metabolism_Homo sapiens_hsa009100.33573256
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31339684
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29959562
105Sphingolipid metabolism_Homo sapiens_hsa006000.28133075
106Homologous recombination_Homo sapiens_hsa034400.27557170
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27521418
108Antigen processing and presentation_Homo sapiens_hsa046120.25531729
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24736904
110Mineral absorption_Homo sapiens_hsa049780.24197055
111Pertussis_Homo sapiens_hsa051330.23651430
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22638515
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21553422
114Selenocompound metabolism_Homo sapiens_hsa004500.19666450
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.19353737
116Graft-versus-host disease_Homo sapiens_hsa053320.19056516
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18605893
118Rheumatoid arthritis_Homo sapiens_hsa053230.14555205

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