CISD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.28537536
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.20318847
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.01623423
4ATP synthesis coupled proton transport (GO:0015986)6.01623423
5respiratory electron transport chain (GO:0022904)5.46778149
6electron transport chain (GO:0022900)5.32843578
7fatty acid elongation (GO:0030497)5.18823065
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.98619841
9L-phenylalanine catabolic process (GO:0006559)4.98619841
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.74793164
11L-phenylalanine metabolic process (GO:0006558)4.74793164
12proteasome assembly (GO:0043248)4.65952452
13regulation of mitochondrial translation (GO:0070129)4.37391325
14axon ensheathment in central nervous system (GO:0032291)4.24093855
15central nervous system myelination (GO:0022010)4.24093855
16chaperone-mediated protein transport (GO:0072321)4.18946320
17respiratory chain complex IV assembly (GO:0008535)4.02617634
18cellular ketone body metabolic process (GO:0046950)3.93638125
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.89637282
20termination of RNA polymerase III transcription (GO:0006386)3.89637282
21aromatic amino acid family catabolic process (GO:0009074)3.77296249
22aldehyde catabolic process (GO:0046185)3.71724185
23protein targeting to mitochondrion (GO:0006626)3.66225890
24cytochrome complex assembly (GO:0017004)3.65956656
25ATP biosynthetic process (GO:0006754)3.53844642
26ribosomal large subunit biogenesis (GO:0042273)3.51087469
27cholesterol biosynthetic process (GO:0006695)3.48077506
28establishment of protein localization to mitochondrion (GO:0072655)3.45272369
29protein localization to mitochondrion (GO:0070585)3.44946670
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44663726
31cullin deneddylation (GO:0010388)3.44187250
32ketone body metabolic process (GO:1902224)3.44100635
33cotranslational protein targeting to membrane (GO:0006613)3.43580847
34glyoxylate metabolic process (GO:0046487)3.43124464
35SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42913324
36coenzyme catabolic process (GO:0009109)3.41596970
37hydrogen ion transmembrane transport (GO:1902600)3.40964307
38protein targeting to ER (GO:0045047)3.36506360
39viral transcription (GO:0019083)3.32020620
40short-chain fatty acid metabolic process (GO:0046459)3.30962575
41translational termination (GO:0006415)3.30041177
42mitochondrial transport (GO:0006839)3.28936733
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27831912
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.27413934
45acetyl-CoA metabolic process (GO:0006084)3.27112061
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24945115
47translation (GO:0006412)3.24652222
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23917336
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.23917336
50NADH dehydrogenase complex assembly (GO:0010257)3.23917336
51protein-cofactor linkage (GO:0018065)3.23286744
52protein localization to endoplasmic reticulum (GO:0070972)3.21560751
53protein complex biogenesis (GO:0070271)3.21456960
54very long-chain fatty acid metabolic process (GO:0000038)3.19847749
55ribosomal small subunit biogenesis (GO:0042274)3.18075014
56water-soluble vitamin biosynthetic process (GO:0042364)3.17967188
57purine nucleoside triphosphate biosynthetic process (GO:0009145)3.15857916
58protein neddylation (GO:0045116)3.14597328
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.14322086
60acyl-CoA metabolic process (GO:0006637)3.13703047
61thioester metabolic process (GO:0035383)3.13703047
62inner mitochondrial membrane organization (GO:0007007)3.13480953
63regulation of cellular amino acid metabolic process (GO:0006521)3.13348892
64purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.12891234
65bile acid biosynthetic process (GO:0006699)3.11814224
66negative regulation of ligase activity (GO:0051352)3.11185956
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11185956
68cofactor catabolic process (GO:0051187)3.09788652
69proton transport (GO:0015992)3.08260475
70thioester biosynthetic process (GO:0035384)3.07193990
71acyl-CoA biosynthetic process (GO:0071616)3.07193990
72sterol biosynthetic process (GO:0016126)3.06499968
73aspartate family amino acid catabolic process (GO:0009068)3.06287242
74long-chain fatty acid biosynthetic process (GO:0042759)3.06160335
75protein deneddylation (GO:0000338)3.06022050
76DNA damage response, detection of DNA damage (GO:0042769)3.05466062
77cysteine metabolic process (GO:0006534)3.05365315
78hydrogen transport (GO:0006818)3.05072449
79fatty-acyl-CoA metabolic process (GO:0035337)3.04737362
80CENP-A containing nucleosome assembly (GO:0034080)3.03181353
81rRNA modification (GO:0000154)3.02877458
82aerobic respiration (GO:0009060)3.02230248
83substantia nigra development (GO:0021762)3.01448273
84chromatin remodeling at centromere (GO:0031055)2.98914728
85fatty-acyl-CoA biosynthetic process (GO:0046949)2.98808531
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98787406
87purine nucleoside monophosphate biosynthetic process (GO:0009127)2.98465578
88purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.98465578
89cellular component biogenesis (GO:0044085)2.97340684
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97264878
91long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.95433101
92mitochondrial respiratory chain complex assembly (GO:0033108)2.93927658
93glutathione biosynthetic process (GO:0006750)2.92379613
94aromatic amino acid family metabolic process (GO:0009072)2.91692174
95maturation of SSU-rRNA (GO:0030490)2.89685887
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.88581310
97intracellular protein transmembrane import (GO:0044743)2.88539308
98tyrosine metabolic process (GO:0006570)2.88051202
99organelle disassembly (GO:1903008)2.87769411
100pseudouridine synthesis (GO:0001522)2.87245957
101establishment of protein localization to mitochondrial membrane (GO:0090151)2.86493396
102translational elongation (GO:0006414)2.86231198
103spliceosomal snRNP assembly (GO:0000387)2.85614769
104oxidative phosphorylation (GO:0006119)2.84850092
105establishment of integrated proviral latency (GO:0075713)2.82618031
106peroxisome fission (GO:0016559)2.80899089
107DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80711533
108cellular respiration (GO:0045333)2.80393465
109nonribosomal peptide biosynthetic process (GO:0019184)2.77763963
110ribosomal small subunit assembly (GO:0000028)2.77694040
111long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.77186970
112translational initiation (GO:0006413)2.77162746
113heme transport (GO:0015886)2.74935893
114regulation of oxidative phosphorylation (GO:0002082)2.74442200
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74409601
116signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74409601
117signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74409601
118fatty acid catabolic process (GO:0009062)2.74137154
119positive regulation of ligase activity (GO:0051351)2.74128160
120signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73124060
121intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73124060
122branched-chain amino acid catabolic process (GO:0009083)2.73079866
123tryptophan catabolic process (GO:0006569)2.72735377
124indole-containing compound catabolic process (GO:0042436)2.72735377
125indolalkylamine catabolic process (GO:0046218)2.72735377
126energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.72095882
127ATP hydrolysis coupled proton transport (GO:0015991)2.72095882
128ribonucleoside triphosphate biosynthetic process (GO:0009201)2.69002450
129kynurenine metabolic process (GO:0070189)2.66527500
130DNA replication checkpoint (GO:0000076)2.66429985
131succinate metabolic process (GO:0006105)2.65928219
132triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.65257670
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64973004
134positive regulation of cellular amine metabolic process (GO:0033240)2.64775219
135signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63842984
136signal transduction involved in DNA damage checkpoint (GO:0072422)2.63842984
137fatty acid beta-oxidation (GO:0006635)2.62864299
138monocarboxylic acid catabolic process (GO:0072329)2.62160782
139tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.61584202
140RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.61584202
141alpha-amino acid catabolic process (GO:1901606)2.61229411
142signal transduction involved in cell cycle checkpoint (GO:0072395)2.61108255
143glutathione metabolic process (GO:0006749)2.60260279
1447-methylguanosine mRNA capping (GO:0006370)2.59916831
145lysine metabolic process (GO:0006553)2.59437367
146lysine catabolic process (GO:0006554)2.59437367
147ribonucleoprotein complex disassembly (GO:0032988)2.58520764
148cellular protein complex disassembly (GO:0043624)2.58069947
149regulation of dopamine metabolic process (GO:0042053)2.57923984
150regulation of catecholamine metabolic process (GO:0042069)2.57923984
151glutathione derivative metabolic process (GO:1901685)2.57809047
152glutathione derivative biosynthetic process (GO:1901687)2.57809047
153ethanol oxidation (GO:0006069)2.56318139
154tryptophan metabolic process (GO:0006568)2.56187080
155viral life cycle (GO:0019058)2.55776607
156tricarboxylic acid cycle (GO:0006099)2.55321965
157regulation of ubiquitin-protein transferase activity (GO:0051438)2.55067243
158ribonucleoside monophosphate biosynthetic process (GO:0009156)2.55012507
159response to methylmercury (GO:0051597)2.54922883
160nucleoside monophosphate biosynthetic process (GO:0009124)2.54910275
161creatine metabolic process (GO:0006600)2.54819468
162iron coordination entity transport (GO:1901678)2.54158631
163glutamate metabolic process (GO:0006536)2.53135430
1647-methylguanosine RNA capping (GO:0009452)2.52865002
165bile acid metabolic process (GO:0008206)2.52609166
166cellular amino acid catabolic process (GO:0009063)2.52563819
167isoprenoid biosynthetic process (GO:0008299)2.51992561
168establishment of mitochondrion localization (GO:0051654)2.51503269
169dicarboxylic acid catabolic process (GO:0043649)2.50607744
170neuron cell-cell adhesion (GO:0007158)2.50303796
171fatty acid oxidation (GO:0019395)2.48986949
172organic acid catabolic process (GO:0016054)2.47717892
173carboxylic acid catabolic process (GO:0046395)2.47717892
174nucleoside triphosphate biosynthetic process (GO:0009142)2.47260015

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.18261355
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.22208686
3ETS1_20019798_ChIP-Seq_JURKAT_Human2.96980603
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.82339655
5EZH2_22144423_ChIP-Seq_EOC_Human2.66241144
6* RXR_22158963_ChIP-Seq_LIVER_Mouse2.64305512
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.63377892
8GBX2_23144817_ChIP-Seq_PC3_Human2.62322506
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.57932114
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55759026
11ELK1_19687146_ChIP-ChIP_HELA_Human2.48207977
12TAF15_26573619_Chip-Seq_HEK293_Human2.39269899
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.38358698
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.33270823
15VDR_22108803_ChIP-Seq_LS180_Human2.16296515
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15652923
17VDR_23849224_ChIP-Seq_CD4+_Human2.10735430
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.10586724
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.06257117
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.04543943
21* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.93429545
22* LXR_22158963_ChIP-Seq_LIVER_Mouse1.93282264
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89333895
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87612933
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87239708
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87001005
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85163634
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84173688
29DCP1A_22483619_ChIP-Seq_HELA_Human1.81049962
30* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79881599
31FOXP3_21729870_ChIP-Seq_TREG_Human1.78366839
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77738977
33TTF2_22483619_ChIP-Seq_HELA_Human1.68214996
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68019624
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66566553
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66392562
37HTT_18923047_ChIP-ChIP_STHdh_Human1.63857498
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62768933
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62711865
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61035537
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60133268
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59597490
43EWS_26573619_Chip-Seq_HEK293_Human1.56169998
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.55808123
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55307072
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54334814
47MYC_18940864_ChIP-ChIP_HL60_Human1.53433195
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50485847
49* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50383527
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49541629
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49122340
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48754250
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48020842
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.46620027
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45378296
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45299858
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44111413
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43814487
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42359472
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41836074
61GABP_19822575_ChIP-Seq_HepG2_Human1.40439651
62* REST_21632747_ChIP-Seq_MESCs_Mouse1.40266010
63SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40106346
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.39852118
65XRN2_22483619_ChIP-Seq_HELA_Human1.38625011
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.36491215
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36376643
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35429963
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35429963
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.34605199
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33744286
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.33427696
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.31676894
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30207287
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29890928
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28943547
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27095242
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.24012813
79P300_19829295_ChIP-Seq_ESCs_Human1.23694134
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23177090
81ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22991798
82ER_23166858_ChIP-Seq_MCF-7_Human1.21312228
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18563964
84E2F7_22180533_ChIP-Seq_HELA_Human1.13564402
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.13045275
86AR_21909140_ChIP-Seq_LNCAP_Human1.11560765
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11553066
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11238528
89POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11208619
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10821627
91TP53_22573176_ChIP-Seq_HFKS_Human1.09873186
92CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09749848
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08038437
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06352390
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06111640
96* SRF_21415370_ChIP-Seq_HL-1_Mouse1.04993957
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03276203
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02906717
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02428858
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02097853
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02033122
102ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01220372
103CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00746082
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.00363366
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99843941
106TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99561322
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.98984724
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98751926
109* NCOR_22424771_ChIP-Seq_293T_Human0.97496904
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97298558
111ERG_21242973_ChIP-ChIP_JURKAT_Human0.97286901
112ZNF274_21170338_ChIP-Seq_K562_Hela0.97201706
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95642363
114EST1_17652178_ChIP-ChIP_JURKAT_Human0.95089655
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94094429
116FUS_26573619_Chip-Seq_HEK293_Human0.93439462
117SOX2_19829295_ChIP-Seq_ESCs_Human0.92908239
118NANOG_19829295_ChIP-Seq_ESCs_Human0.92908239
119POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92635270
120SOX2_16153702_ChIP-ChIP_HESCs_Human0.91536755
121MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91188408
122IRF1_19129219_ChIP-ChIP_H3396_Human0.90971460
123IGF1R_20145208_ChIP-Seq_DFB_Human0.90068294
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88688423
125CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88018344
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87641317
127MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87000611
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.86695598
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85638822
130REST_19997604_ChIP-ChIP_NEURONS_Mouse0.84041460
131RNF2_27304074_Chip-Seq_NSC_Mouse0.83085318
132JUN_21703547_ChIP-Seq_K562_Human0.82463679
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82169128
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81882803
135SMAD4_21799915_ChIP-Seq_A2780_Human0.81818448
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.81435753
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80663588
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80505986
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80170797
140HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.79882072
141* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79734595
142ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79385933
143PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.79351694
144* EOMES_21245162_ChIP-Seq_HESCs_Human0.79034238
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78403191
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.77737843
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.77142119
148SOX17_20123909_ChIP-Seq_XEN_Mouse0.77092959
149SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76893438
150SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76878955
151THAP11_20581084_ChIP-Seq_MESCs_Mouse0.76722975
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76715038
153SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74775843
154NFE2_27457419_Chip-Seq_LIVER_Mouse0.74303158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.03493723
2MP0005360_urolithiasis3.78986371
3MP0003806_abnormal_nucleotide_metabolis3.62165924
4MP0003880_abnormal_central_pattern3.22441817
5MP0008875_abnormal_xenobiotic_pharmacok3.02097836
6MP0005085_abnormal_gallbladder_physiolo2.99881414
7MP0002837_dystrophic_cardiac_calcinosis2.73962282
8MP0001529_abnormal_vocalization2.68722274
9MP0005365_abnormal_bile_salt2.51852114
10MP0003195_calcinosis2.49108329
11MP0001905_abnormal_dopamine_level2.27539708
12MP0008058_abnormal_DNA_repair2.16618579
13MP0005332_abnormal_amino_acid2.14240130
14MP0004043_abnormal_pH_regulation2.13677739
15MP0004270_analgesia2.10880915
16MP0002938_white_spotting2.10598194
17MP0006276_abnormal_autonomic_nervous1.95246686
18* MP0006036_abnormal_mitochondrial_physio1.94042114
19MP0004142_abnormal_muscle_tone1.93212192
20MP0002822_catalepsy1.91237062
21MP0000920_abnormal_myelination1.88198552
22MP0003329_amyloid_beta_deposits1.84965515
23MP0002272_abnormal_nervous_system1.84029892
24MP0000372_irregular_coat_pigmentation1.74983227
25MP0002064_seizures1.71851451
26MP0005451_abnormal_body_composition1.71175966
27MP0005083_abnormal_biliary_tract1.68167916
28MP0001968_abnormal_touch/_nociception1.65672524
29MP0009745_abnormal_behavioral_response1.65067371
30MP0002638_abnormal_pupillary_reflex1.61041129
31MP0001440_abnormal_grooming_behavior1.56311921
32MP0002736_abnormal_nociception_after1.56001051
33MP0003646_muscle_fatigue1.54381881
34MP0006035_abnormal_mitochondrial_morpho1.52683626
35MP0003693_abnormal_embryo_hatching1.51062600
36MP0002734_abnormal_mechanical_nocicepti1.50890499
37MP0000751_myopathy1.50593823
38MP0002735_abnormal_chemical_nociception1.50460602
39MP0004957_abnormal_blastocyst_morpholog1.47521090
40MP0003635_abnormal_synaptic_transmissio1.45583187
41MP0002876_abnormal_thyroid_physiology1.45505748
42MP0009046_muscle_twitch1.45442476
43MP0004859_abnormal_synaptic_plasticity1.43293375
44MP0001486_abnormal_startle_reflex1.37281753
45MP0002909_abnormal_adrenal_gland1.34980322
46MP0010329_abnormal_lipoprotein_level1.33035976
47MP0001984_abnormal_olfaction1.31532961
48MP0006292_abnormal_olfactory_placode1.30627898
49MP0008877_abnormal_DNA_methylation1.29540017
50MP0002572_abnormal_emotion/affect_behav1.28526781
51MP0003941_abnormal_skin_development1.28149612
52MP0002160_abnormal_reproductive_system1.28085691
53MP0010094_abnormal_chromosome_stability1.27921213
54MP0004036_abnormal_muscle_relaxation1.26643126
55MP0005367_renal/urinary_system_phenotyp1.26367472
56MP0000516_abnormal_urinary_system1.26367472
57MP0002118_abnormal_lipid_homeostasis1.24948106
58MP0009840_abnormal_foam_cell1.24259435
59MP0009379_abnormal_foot_pigmentation1.23957084
60MP0005551_abnormal_eye_electrophysiolog1.22926059
61MP0002229_neurodegeneration1.22699524
62MP0002234_abnormal_pharynx_morphology1.22037726
63MP0002733_abnormal_thermal_nociception1.21835362
64MP0003786_premature_aging1.21574741
65MP0002102_abnormal_ear_morphology1.20960895
66MP0005386_behavior/neurological_phenoty1.20913450
67MP0004924_abnormal_behavior1.20913450
68MP0000749_muscle_degeneration1.20229442
69MP0002067_abnormal_sensory_capabilities1.18332217
70MP0002063_abnormal_learning/memory/cond1.17001055
71MP0005584_abnormal_enzyme/coenzyme_acti1.16794535
72MP0002163_abnormal_gland_morphology1.16551564
73MP0005535_abnormal_body_temperature1.15599729
74MP0003011_delayed_dark_adaptation1.15035686
75MP0001970_abnormal_pain_threshold1.14466229
76MP0003690_abnormal_glial_cell1.14205794
77MP0004019_abnormal_vitamin_homeostasis1.13878172
78MP0008872_abnormal_physiological_respon1.12832263
79MP0005084_abnormal_gallbladder_morpholo1.12184793
80MP0000747_muscle_weakness1.10067509
81MP0003123_paternal_imprinting1.10009662
82MP0003186_abnormal_redox_activity1.09596767
83MP0005379_endocrine/exocrine_gland_phen1.08813681
84MP0005253_abnormal_eye_physiology1.08183522
85MP0001666_abnormal_nutrient_absorption1.07809086
86MP0005636_abnormal_mineral_homeostasis1.06676185
87MP0003950_abnormal_plasma_membrane1.06489531
88MP0001764_abnormal_homeostasis1.05674211
89MP0001188_hyperpigmentation1.03796265
90MP0003252_abnormal_bile_duct1.03445083
91MP0000604_amyloidosis1.02143836
92MP0008789_abnormal_olfactory_epithelium1.01802948
93MP0000678_abnormal_parathyroid_gland1.01680982
94MP0000778_abnormal_nervous_system1.00603515
95MP0004215_abnormal_myocardial_fiber1.00493648
96MP0005645_abnormal_hypothalamus_physiol0.98932466
97MP0003567_abnormal_fetal_cardiomyocyte0.98754998
98MP0000631_abnormal_neuroendocrine_gland0.98391784
99MP0003077_abnormal_cell_cycle0.97562145
100MP0009697_abnormal_copulation0.97500088
101MP0004145_abnormal_muscle_electrophysio0.97488008
102MP0008932_abnormal_embryonic_tissue0.96969311
103MP0005187_abnormal_penis_morphology0.96953127
104MP0004742_abnormal_vestibular_system0.96372293
105MP0001661_extended_life_span0.95441948
106MP0001485_abnormal_pinna_reflex0.95187049
107MP0005646_abnormal_pituitary_gland0.95170050
108MP0005330_cardiomyopathy0.94723861
109MP0005423_abnormal_somatic_nervous0.93410022
110MP0003136_yellow_coat_color0.93094600
111MP0002066_abnormal_motor_capabilities/c0.92948148
112MP0002090_abnormal_vision0.92846641
113MP0001501_abnormal_sleep_pattern0.92451227
114MP0004147_increased_porphyrin_level0.91849263
115MP0005266_abnormal_metabolism0.91176473
116MP0010386_abnormal_urinary_bladder0.89506586
117MP0003634_abnormal_glial_cell0.88326956
118MP0004085_abnormal_heartbeat0.88023985
119MP0000230_abnormal_systemic_arterial0.87822702
120MP0002557_abnormal_social/conspecific_i0.86623427
121MP0003121_genomic_imprinting0.86520871
122MP0003137_abnormal_impulse_conducting0.85499976
123MP0005408_hypopigmentation0.84499044
124MP0002332_abnormal_exercise_endurance0.83990659
125MP0004885_abnormal_endolymph0.83091208
126MP0009643_abnormal_urine_homeostasis0.82679306
127MP0000358_abnormal_cell_content/0.82614056
128MP0000647_abnormal_sebaceous_gland0.79371804
129MP0006072_abnormal_retinal_apoptosis0.79006417
130MP0008775_abnormal_heart_ventricle0.78908153
131MP0005620_abnormal_muscle_contractility0.78619946
132MP0000955_abnormal_spinal_cord0.78549655
133MP0001986_abnormal_taste_sensitivity0.78014537
134MP0002184_abnormal_innervation0.77604225
135MP0002882_abnormal_neuron_morphology0.77383546
136MP0004130_abnormal_muscle_cell0.76048769
137MP0005410_abnormal_fertilization0.75850715
138MP0003868_abnormal_feces_composition0.75692652
139MP0005389_reproductive_system_phenotype0.75688898
140MP0008260_abnormal_autophagy0.75529980
141MP0005319_abnormal_enzyme/_coenzyme0.74968592
142MP0003656_abnormal_erythrocyte_physiolo0.74826820
143MP0002752_abnormal_somatic_nervous0.74351602
144MP0003718_maternal_effect0.74303573

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.51428118
2Acute encephalopathy (HP:0006846)5.11350034
3Abnormal mitochondria in muscle tissue (HP:0008316)5.09759329
4Progressive macrocephaly (HP:0004481)4.58731747
5Mitochondrial inheritance (HP:0001427)4.58483854
6Cerebral edema (HP:0002181)4.37149997
7Increased serum pyruvate (HP:0003542)4.24560244
8Abnormality of glycolysis (HP:0004366)4.24560244
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.20515106
10Hepatocellular necrosis (HP:0001404)4.17368035
11Hepatic necrosis (HP:0002605)4.05423070
12Increased CSF lactate (HP:0002490)4.04732392
13Myokymia (HP:0002411)3.44370136
14Leukodystrophy (HP:0002415)3.32865339
15Lipid accumulation in hepatocytes (HP:0006561)3.32618532
16Increased hepatocellular lipid droplets (HP:0006565)3.29362164
17Renal Fanconi syndrome (HP:0001994)3.29165491
18Lactic acidosis (HP:0003128)3.15794502
19Pheochromocytoma (HP:0002666)3.04105790
20Optic disc pallor (HP:0000543)3.02766441
21Respiratory failure (HP:0002878)3.00415079
22Increased intramyocellular lipid droplets (HP:0012240)3.00382680
23Lethargy (HP:0001254)2.95502546
24Intrahepatic cholestasis (HP:0001406)2.93991643
25Neuroendocrine neoplasm (HP:0100634)2.90767407
263-Methylglutaconic aciduria (HP:0003535)2.90422636
27Increased muscle lipid content (HP:0009058)2.85487023
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.82795803
29Hyperventilation (HP:0002883)2.76950006
30Macrocytic anemia (HP:0001972)2.74519342
31Exertional dyspnea (HP:0002875)2.70312968
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70179980
33Abnormality of alanine metabolism (HP:0010916)2.70179980
34Hyperalaninemia (HP:0003348)2.70179980
35Hypobetalipoproteinemia (HP:0003563)2.67373269
36Hyperlipoproteinemia (HP:0010980)2.67116510
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66233005
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66233005
39Ketosis (HP:0001946)2.65986683
40Exercise intolerance (HP:0003546)2.63816825
41Increased serum lactate (HP:0002151)2.60795325
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59202017
43Neurofibrillary tangles (HP:0002185)2.55738649
44Congenital, generalized hypertrichosis (HP:0004540)2.53861588
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52830774
46Dicarboxylic aciduria (HP:0003215)2.52830774
47Hyperammonemia (HP:0001987)2.52792253
48Limb dystonia (HP:0002451)2.52441169
49Abnormality of fatty-acid metabolism (HP:0004359)2.50098702
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.49779483
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.49779483
52Abnormality of serine family amino acid metabolism (HP:0010894)2.48589590
53Abnormality of glycine metabolism (HP:0010895)2.48589590
54Abnormality of urine glucose concentration (HP:0011016)2.48406284
55Glycosuria (HP:0003076)2.48406284
56Xanthomatosis (HP:0000991)2.47667236
57Respiratory difficulties (HP:0002880)2.42746775
58Parakeratosis (HP:0001036)2.41355072
59Ketoacidosis (HP:0001993)2.41194847
60Prolonged partial thromboplastin time (HP:0003645)2.40782775
61Hyperglycinemia (HP:0002154)2.39849540
62Cholecystitis (HP:0001082)2.37488358
63Abnormal gallbladder physiology (HP:0012438)2.37488358
64Vomiting (HP:0002013)2.36687441
65Sensory axonal neuropathy (HP:0003390)2.35205350
66Deep venous thrombosis (HP:0002625)2.33680478
67Methylmalonic acidemia (HP:0002912)2.31767015
68Cerebral hemorrhage (HP:0001342)2.31483906
69CNS demyelination (HP:0007305)2.31089924
70Hyperglycinuria (HP:0003108)2.26493580
71Methylmalonic aciduria (HP:0012120)2.26059931
72Abnormality of renal resorption (HP:0011038)2.24654507
73Hyperphosphaturia (HP:0003109)2.24300352
74Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.20341502
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18581372
76X-linked dominant inheritance (HP:0001423)2.17082073
77Type I transferrin isoform profile (HP:0003642)2.16176382
78Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15977658
79Metabolic acidosis (HP:0001942)2.13320731
80Abnormality of vitamin B metabolism (HP:0004340)2.11558085
81Focal motor seizures (HP:0011153)2.11026505
82Megaloblastic anemia (HP:0001889)2.09081215
83Muscle hypertrophy of the lower extremities (HP:0008968)2.08640239
84Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.08389850
85Abnormality of cells of the erythroid lineage (HP:0012130)2.08297741
86Abnormal number of erythroid precursors (HP:0012131)2.08204426
87Medial flaring of the eyebrow (HP:0010747)2.07586633
88Hypoglycemic coma (HP:0001325)2.05926300
89Abnormality of the vitamin B12 metabolism (HP:0004341)2.01703456
90Generalized aminoaciduria (HP:0002909)2.00508431
91Abnormal urine phosphate concentration (HP:0012599)1.99745237
92Cerebral inclusion bodies (HP:0100314)1.98310700
93Spastic paraparesis (HP:0002313)1.97966983
94Aplastic anemia (HP:0001915)1.97258039
95Abnormality of methionine metabolism (HP:0010901)1.96679843
96Gout (HP:0001997)1.96532046
97Reticulocytopenia (HP:0001896)1.95539404
98Cerebral hypomyelination (HP:0006808)1.94904188
99Abnormality of the corticospinal tract (HP:0002492)1.94099658
100Delayed CNS myelination (HP:0002188)1.93126418
101Retinal dysplasia (HP:0007973)1.91106914
102Tetany (HP:0001281)1.90211286
103Brushfield spots (HP:0001088)1.90073437
104Abnormality of serum amino acid levels (HP:0003112)1.88213174
105Delusions (HP:0000746)1.87989875
106Hypomagnesemia (HP:0002917)1.87828704
107Gait imbalance (HP:0002141)1.87633308
108Abnormal pupillary function (HP:0007686)1.85873171
109Myoglobinuria (HP:0002913)1.85348347
110Emotional lability (HP:0000712)1.84827791
111Hypothermia (HP:0002045)1.84423656
112Reduced antithrombin III activity (HP:0001976)1.83820285
113Abnormal gallbladder morphology (HP:0012437)1.83167410
114Poor suck (HP:0002033)1.82937477
115Increased circulating renin level (HP:0000848)1.82627371
116Hypolipoproteinemia (HP:0010981)1.82465069
117Nemaline bodies (HP:0003798)1.82317332
118Irritability (HP:0000737)1.81978748
119Abnormality of the anterior horn cell (HP:0006802)1.81609087
120Degeneration of anterior horn cells (HP:0002398)1.81609087
121Exercise-induced muscle cramps (HP:0003710)1.80904127
122Muscle fiber inclusion bodies (HP:0100299)1.80446044
123Calf muscle hypertrophy (HP:0008981)1.80356349
124Alkalosis (HP:0001948)1.79039340
125Congenital ichthyosiform erythroderma (HP:0007431)1.78890826
126Amniotic constriction ring (HP:0009775)1.77755653
127Abnormality of placental membranes (HP:0011409)1.77755653
128Molar tooth sign on MRI (HP:0002419)1.76389247
129Abnormality of midbrain morphology (HP:0002418)1.76389247
130Fat malabsorption (HP:0002630)1.76135207
131Congenital primary aphakia (HP:0007707)1.76097691
132Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.75847636
133Palpitations (HP:0001962)1.74881690
134Hyperinsulinemic hypoglycemia (HP:0000825)1.73541689
135Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.71433704
136Microretrognathia (HP:0000308)1.68177378
137Absence seizures (HP:0002121)1.67518116
138Pancreatic fibrosis (HP:0100732)1.67151520
139Abnormality of the labia minora (HP:0012880)1.66959394
140Hyperphosphatemia (HP:0002905)1.66454355
141Blindness (HP:0000618)1.65874486
142Abnormality of magnesium homeostasis (HP:0004921)1.65400096
143Colon cancer (HP:0003003)1.63194494
144Oral leukoplakia (HP:0002745)1.62036365
145Renal cortical cysts (HP:0000803)1.61777065
146Atonic seizures (HP:0010819)1.60678833
147Nephrogenic diabetes insipidus (HP:0009806)1.60203445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.16809417
2OXSR13.69180910
3BUB13.18839069
4WNK43.07234309
5VRK22.96058543
6BCKDK2.90490128
7ARAF2.58135018
8CASK2.49264283
9NEK12.46826518
10NME12.40375843
11PBK2.00530819
12BCR1.96130768
13PNCK1.95622532
14EPHA41.92671681
15EIF2AK11.92377727
16CDK191.90531895
17VRK11.88000457
18GRK51.87519722
19ZAK1.84345383
20CDC71.82483654
21LIMK11.77327167
22MAP3K121.72914876
23EIF2AK31.69061555
24PHKG21.64784811
25PHKG11.64784811
26SRPK11.63726013
27STK161.62231741
28TSSK61.61425071
29WNK31.59700847
30PLK31.52094836
31GRK71.51066918
32TNIK1.50587682
33MAP4K21.49062477
34PLK41.47753016
35PKN11.46287413
36CSNK1G31.42468050
37CAMK2B1.42274742
38OBSCN1.42014862
39MYLK1.40254302
40MAP2K71.37500408
41MUSK1.35341776
42MST41.34791811
43CAMK2D1.34740503
44MARK11.32626775
45TTK1.31544366
46TRIM281.30931950
47WEE11.30181482
48PINK11.27879826
49CAMK2G1.26551720
50UHMK11.25689660
51MAP2K41.21235461
52MAPKAPK51.19302087
53NTRK31.17829300
54NTRK11.17621357
55FRK1.17321694
56INSRR1.17087771
57MAP3K41.13137940
58CAMK2A1.12185766
59BRAF1.09194453
60CSNK1G21.05031132
61DYRK21.04761902
62ERBB41.02201028
63MET1.00764576
64PLK11.00680168
65CSNK1G10.97189720
66NME20.95947184
67PDK40.95400208
68PDK30.95400208
69ADRBK20.93728760
70CCNB10.92665907
71NUAK10.92592313
72TAF10.90415854
73GRK10.89333327
74BRSK20.89196332
75SGK4940.86212355
76SGK2230.86212355
77TESK20.86148487
78PLK20.86090354
79CDK140.85942637
80ERBB30.85767057
81MINK10.85630630
82ABL20.85167276
83WNK10.83547059
84PAK30.82413236
85MAPK130.82107881
86PRKCG0.79449601
87TESK10.78815794
88CSNK1A1L0.78663576
89MAPK150.78565016
90BMPR20.75772864
91BMPR1B0.75419269
92MKNK20.73862496
93DAPK10.73840933
94ROCK20.73731712
95PRPF4B0.73569455
96PIK3CG0.72759087
97ADRBK10.70490592
98AURKB0.70217227
99MAP3K90.69933995
100CDK180.69769331
101CDK150.69739581
102PRKCE0.69357885
103CDK50.69141738
104KSR20.69093313
105BRSK10.68900688
106PAK60.68608685
107MKNK10.67562790
108EPHB10.66487429
109DAPK20.65793003
110CSNK2A20.65643950
111MAP3K110.65550272
112PRKACA0.63759181
113PIK3CA0.62686964
114NEK60.62425517
115CDK11A0.61576173
116PDK20.61049115
117CHEK20.59836580
118FGR0.57417689
119ACVR1B0.54470825
120PDPK10.53544618
121CSNK2A10.53074202
122CDK80.52523334
123PTK2B0.51530779
124CSNK1E0.51430763
125ILK0.51094923
126RPS6KA50.51057814
127AURKA0.49479463
128MAPK120.49006953
129IRAK20.48863332
130DAPK30.47648152
131CAMKK20.45955107
132ATR0.45107254
133MST1R0.44315284
134EIF2AK20.42657172
135CSNK1A10.42563037
136STK40.41940523
137PRKG10.41789197
138PRKCQ0.40961516
139NTRK20.38531304
140PRKACB0.37010236
141PRKCA0.34648287
142PRKACG0.33544775
143TLK10.33011444

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.17848484
2Parkinsons disease_Homo sapiens_hsa050123.39700456
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.08085807
4Fatty acid elongation_Homo sapiens_hsa000622.82981788
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61216105
6Alzheimers disease_Homo sapiens_hsa050102.58661057
7Butanoate metabolism_Homo sapiens_hsa006502.39738829
8Propanoate metabolism_Homo sapiens_hsa006402.37157221
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.27897928
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22263891
11Huntingtons disease_Homo sapiens_hsa050162.20343990
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.15136162
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.13069494
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11894924
15Sulfur metabolism_Homo sapiens_hsa009202.05505975
16Steroid biosynthesis_Homo sapiens_hsa001001.99871846
17Pyruvate metabolism_Homo sapiens_hsa006201.93421616
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88969293
19Mismatch repair_Homo sapiens_hsa034301.88676531
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81354395
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77147586
22Fatty acid degradation_Homo sapiens_hsa000711.72899411
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72799351
24Peroxisome_Homo sapiens_hsa041461.72678157
25Cardiac muscle contraction_Homo sapiens_hsa042601.72413033
26Homologous recombination_Homo sapiens_hsa034401.68862171
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66531806
28Fatty acid metabolism_Homo sapiens_hsa012121.62200125
29DNA replication_Homo sapiens_hsa030301.61852540
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60813060
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60419466
32Histidine metabolism_Homo sapiens_hsa003401.58184358
33Tryptophan metabolism_Homo sapiens_hsa003801.55108805
34Collecting duct acid secretion_Homo sapiens_hsa049661.54421490
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51835644
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47373296
37Phenylalanine metabolism_Homo sapiens_hsa003601.35760729
38Arginine biosynthesis_Homo sapiens_hsa002201.34719484
39Nucleotide excision repair_Homo sapiens_hsa034201.32717900
40Tyrosine metabolism_Homo sapiens_hsa003501.32157208
41Protein export_Homo sapiens_hsa030601.30634378
42Proteasome_Homo sapiens_hsa030501.30562980
43Basal transcription factors_Homo sapiens_hsa030221.30184224
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29021016
45Pyrimidine metabolism_Homo sapiens_hsa002401.25710121
46Chemical carcinogenesis_Homo sapiens_hsa052041.25230578
47beta-Alanine metabolism_Homo sapiens_hsa004101.24804826
48Carbon metabolism_Homo sapiens_hsa012001.22402756
49RNA degradation_Homo sapiens_hsa030181.18552091
50Arginine and proline metabolism_Homo sapiens_hsa003301.15337407
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.15297067
52Spliceosome_Homo sapiens_hsa030401.11940668
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07816763
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.07121986
55One carbon pool by folate_Homo sapiens_hsa006701.05510376
56Fanconi anemia pathway_Homo sapiens_hsa034601.04399761
57Purine metabolism_Homo sapiens_hsa002301.04215884
58Folate biosynthesis_Homo sapiens_hsa007901.03490051
59PPAR signaling pathway_Homo sapiens_hsa033201.02502096
60Retinol metabolism_Homo sapiens_hsa008300.97869342
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.97657536
62Base excision repair_Homo sapiens_hsa034100.95568970
63RNA transport_Homo sapiens_hsa030130.95072182
64Glutathione metabolism_Homo sapiens_hsa004800.93807570
65Metabolic pathways_Homo sapiens_hsa011000.91650614
66Synaptic vesicle cycle_Homo sapiens_hsa047210.89441908
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86300900
68Vitamin B6 metabolism_Homo sapiens_hsa007500.84337978
69Biosynthesis of amino acids_Homo sapiens_hsa012300.80715774
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80190581
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79891692
72Complement and coagulation cascades_Homo sapiens_hsa046100.79788318
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.78401718
74Nitrogen metabolism_Homo sapiens_hsa009100.78344044
75Vibrio cholerae infection_Homo sapiens_hsa051100.77583704
76Nicotine addiction_Homo sapiens_hsa050330.76859719
77Ether lipid metabolism_Homo sapiens_hsa005650.72797234
78Linoleic acid metabolism_Homo sapiens_hsa005910.72762827
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72512711
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72025781
81Non-homologous end-joining_Homo sapiens_hsa034500.69967923
82Sulfur relay system_Homo sapiens_hsa041220.69112265
83Bile secretion_Homo sapiens_hsa049760.66502870
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.66393986
85GABAergic synapse_Homo sapiens_hsa047270.65715273
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64301975
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63774354
88Oocyte meiosis_Homo sapiens_hsa041140.59058216
89Fat digestion and absorption_Homo sapiens_hsa049750.58849139
90Starch and sucrose metabolism_Homo sapiens_hsa005000.57314851
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.54550357
92Mineral absorption_Homo sapiens_hsa049780.52934327
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52341342
94Cell cycle_Homo sapiens_hsa041100.49181121
95Ribosome_Homo sapiens_hsa030100.48097310
96Circadian rhythm_Homo sapiens_hsa047100.45219801
97Serotonergic synapse_Homo sapiens_hsa047260.43111926
98Glycerolipid metabolism_Homo sapiens_hsa005610.42334357
99RNA polymerase_Homo sapiens_hsa030200.41564236
100Vitamin digestion and absorption_Homo sapiens_hsa049770.38974118
101Regulation of autophagy_Homo sapiens_hsa041400.38968042
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36722951
103Fructose and mannose metabolism_Homo sapiens_hsa000510.35223492
104Insulin secretion_Homo sapiens_hsa049110.34701344
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34545874
106Amphetamine addiction_Homo sapiens_hsa050310.34433504
107Arachidonic acid metabolism_Homo sapiens_hsa005900.33728363
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33614450
109Taste transduction_Homo sapiens_hsa047420.33228748
110Phototransduction_Homo sapiens_hsa047440.32335469
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28904427
112Sphingolipid metabolism_Homo sapiens_hsa006000.28751716
113Morphine addiction_Homo sapiens_hsa050320.27973618
114Glutamatergic synapse_Homo sapiens_hsa047240.27843305
115Pentose phosphate pathway_Homo sapiens_hsa000300.27716601
116ABC transporters_Homo sapiens_hsa020100.26587909
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.24875273
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23976030
119Rheumatoid arthritis_Homo sapiens_hsa053230.22452360
120Selenocompound metabolism_Homo sapiens_hsa004500.20842955
121Caffeine metabolism_Homo sapiens_hsa002320.18286693
122Circadian entrainment_Homo sapiens_hsa047130.17361824
123Dopaminergic synapse_Homo sapiens_hsa047280.17303472

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