CIR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.26552702
2central nervous system myelination (GO:0022010)7.26552702
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.41249594
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.36794177
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.18925851
6ATP synthesis coupled proton transport (GO:0015986)5.18925851
7fatty acid elongation (GO:0030497)4.87833479
8long-chain fatty acid biosynthetic process (GO:0042759)4.56649324
9protein neddylation (GO:0045116)4.51903818
10respiratory electron transport chain (GO:0022904)4.44951866
11presynaptic membrane assembly (GO:0097105)4.39151693
12electron transport chain (GO:0022900)4.37198117
13neuron cell-cell adhesion (GO:0007158)4.14427948
14chaperone-mediated protein transport (GO:0072321)4.10242916
15presynaptic membrane organization (GO:0097090)4.02335705
16neutrophil activation involved in immune response (GO:0002283)3.84009951
17ribosomal small subunit biogenesis (GO:0042274)3.79992084
18pyrimidine-containing compound transmembrane transport (GO:0072531)3.78151210
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.71330185
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.71330185
21NADH dehydrogenase complex assembly (GO:0010257)3.71330185
22myelination (GO:0042552)3.65131397
23ensheathment of neurons (GO:0007272)3.60571369
24axon ensheathment (GO:0008366)3.60571369
25viral transcription (GO:0019083)3.51700710
26neuron remodeling (GO:0016322)3.48837590
27histone H2B ubiquitination (GO:0033523)3.48740371
28negative regulation of interleukin-12 production (GO:0032695)3.43915150
29substantia nigra development (GO:0021762)3.40013135
30negative regulation of execution phase of apoptosis (GO:1900118)3.39605246
31dopamine biosynthetic process (GO:0042416)3.39074734
32translational termination (GO:0006415)3.36014523
33protein complex biogenesis (GO:0070271)3.33256804
34positive regulation of gamma-delta T cell activation (GO:0046645)3.28722413
35GPI anchor biosynthetic process (GO:0006506)3.26671353
36regulation of collateral sprouting (GO:0048670)3.25297619
37negative regulation of neurotransmitter transport (GO:0051589)3.24699577
38GTP biosynthetic process (GO:0006183)3.23293490
39piRNA metabolic process (GO:0034587)3.20392812
40preassembly of GPI anchor in ER membrane (GO:0016254)3.19643184
41limb bud formation (GO:0060174)3.17854747
42neutrophil activation (GO:0042119)3.17785383
43oligosaccharide catabolic process (GO:0009313)3.15857867
44centriole replication (GO:0007099)3.14532463
45negative regulation of interleukin-1 beta production (GO:0032691)3.12770703
46granulocyte activation (GO:0036230)3.11698903
47glycerophospholipid catabolic process (GO:0046475)3.09378076
48hydrogen ion transmembrane transport (GO:1902600)3.07845691
49cotranslational protein targeting to membrane (GO:0006613)3.06847471
50immunoglobulin mediated immune response (GO:0016064)3.06302089
51establishment of protein localization to mitochondrial membrane (GO:0090151)3.06285474
52GPI anchor metabolic process (GO:0006505)3.05299635
53response to methylmercury (GO:0051597)3.05107974
54neuronal action potential propagation (GO:0019227)3.03550173
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.02816572
56positive regulation of mast cell activation (GO:0033005)2.98963922
57epithelial cilium movement (GO:0003351)2.96991829
58protein targeting to ER (GO:0045047)2.95974720
59negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95790043
60regulation of catecholamine metabolic process (GO:0042069)2.95634511
61regulation of dopamine metabolic process (GO:0042053)2.95634511
62negative regulation of interleukin-1 production (GO:0032692)2.92029646
63negative regulation of cell killing (GO:0031342)2.91514478
64negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.91514478
65neurotransmitter uptake (GO:0001504)2.89802323
66proteasome assembly (GO:0043248)2.88392391
67proton transport (GO:0015992)2.87862036
68SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87377471
69protein localization to endoplasmic reticulum (GO:0070972)2.87165730
70neurotransmitter catabolic process (GO:0042135)2.86471206
71protein localization to cilium (GO:0061512)2.86087505
72mitochondrial respiratory chain complex assembly (GO:0033108)2.85364811
73cellular extravasation (GO:0045123)2.85092563
74establishment of protein localization to endoplasmic reticulum (GO:0072599)2.84551920
75negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.83200414
76gamma-aminobutyric acid signaling pathway (GO:0007214)2.82031323
77hydrogen transport (GO:0006818)2.79706646
78positive regulation of action potential (GO:0045760)2.79177504
79phenol-containing compound catabolic process (GO:0019336)2.77149447
80microglial cell activation (GO:0001774)2.76235732
81respiratory burst (GO:0045730)2.76200587
82response to peptidoglycan (GO:0032494)2.76179895
83positive regulation of cellular amine metabolic process (GO:0033240)2.76015680
84cholesterol biosynthetic process (GO:0006695)2.75627564
85retinal cone cell development (GO:0046549)2.73775466
86positive regulation of mast cell degranulation (GO:0043306)2.73653420
87positive regulation of mast cell activation involved in immune response (GO:0033008)2.73653420
88axonemal dynein complex assembly (GO:0070286)2.73387507
89regulation of mast cell activation (GO:0033003)2.73196462
90regulation of memory T cell differentiation (GO:0043380)2.73091300
91neuron recognition (GO:0008038)2.72593637
92oligodendrocyte differentiation (GO:0048709)2.71887540
93positive regulation of interleukin-1 beta secretion (GO:0050718)2.71736266
94regulation of B cell receptor signaling pathway (GO:0050855)2.71125072
95negative regulation of neurotransmitter secretion (GO:0046929)2.70453991
96positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.69413049
97positive regulation of antigen processing and presentation (GO:0002579)2.68712225
98organelle membrane fusion (GO:0090174)2.68344493
99DNA deamination (GO:0045006)2.67083377
100cellular protein complex disassembly (GO:0043624)2.66353581
101epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.66080078
102multicellular organism reproduction (GO:0032504)2.65835893
103viral life cycle (GO:0019058)2.65701517
104positive regulation of toll-like receptor signaling pathway (GO:0034123)2.63686849
105regulation of axon regeneration (GO:0048679)2.62283968
106regulation of neuron projection regeneration (GO:0070570)2.62283968
107modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62259677
108positive regulation by organism of defense response of other organism involved in symbiotic interact2.62259677
109modulation by symbiont of host immune response (GO:0052553)2.62259677
110positive regulation by symbiont of host defense response (GO:0052509)2.62259677
111modulation by symbiont of host defense response (GO:0052031)2.62259677
112modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62259677
113membrane assembly (GO:0071709)2.61449221
114positive regulation of oligodendrocyte differentiation (GO:0048714)2.61168226
115platelet dense granule organization (GO:0060155)2.60730202
116macrophage activation involved in immune response (GO:0002281)2.60395494
117regulation of interleukin-6 biosynthetic process (GO:0045408)2.60385011
118positive regulation of synapse assembly (GO:0051965)2.59265300
119detection of molecule of bacterial origin (GO:0032490)2.58226382
120cilium movement (GO:0003341)2.57744308
121protein localization to synapse (GO:0035418)2.57498544
122cytokine metabolic process (GO:0042107)2.56176761
123regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.55495236
124positive regulation of interleukin-1 secretion (GO:0050716)2.55373374
125neuron fate determination (GO:0048664)2.54740978
126magnesium ion transport (GO:0015693)2.54729567
127activated T cell proliferation (GO:0050798)2.54623797
128purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.54236485
129transmission of nerve impulse (GO:0019226)2.54085476
130regulation of DNA methylation (GO:0044030)2.54081519
131response to interferon-beta (GO:0035456)2.53238333
132interferon-gamma-mediated signaling pathway (GO:0060333)2.52813180
133detection of temperature stimulus involved in sensory perception (GO:0050961)2.52686543
134detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.52686543
135neural nucleus development (GO:0048857)2.52003744
136protoporphyrinogen IX metabolic process (GO:0046501)2.51793806
137regulation of interleukin-1 beta secretion (GO:0050706)2.51680078
138protoporphyrinogen IX biosynthetic process (GO:0006782)2.50890105
139amino sugar catabolic process (GO:0046348)2.50444516
140positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.50303477
141cilium or flagellum-dependent cell motility (GO:0001539)2.50220001
142dendritic spine morphogenesis (GO:0060997)2.49975217
143cytidine deamination (GO:0009972)2.49811486
144cytidine metabolic process (GO:0046087)2.49811486
145cytidine catabolic process (GO:0006216)2.49811486
146autophagic vacuole fusion (GO:0000046)2.49640820
147cranial nerve development (GO:0021545)2.49322086
148regulation of meiosis I (GO:0060631)2.49170470
149chemokine-mediated signaling pathway (GO:0070098)2.48951414
150myeloid cell activation involved in immune response (GO:0002275)2.48877981
151isoprenoid biosynthetic process (GO:0008299)2.48603334
152purine nucleoside triphosphate biosynthetic process (GO:0009145)2.48574815
153regulation of cilium movement (GO:0003352)2.46945743
154cranial nerve morphogenesis (GO:0021602)2.46660795
155catecholamine biosynthetic process (GO:0042423)2.46024219
156catechol-containing compound biosynthetic process (GO:0009713)2.46024219
157DNA methylation involved in gamete generation (GO:0043046)2.44573465
158regulation of glutamate secretion (GO:0014048)2.44549511
159superoxide anion generation (GO:0042554)2.43978758
160transcription elongation from RNA polymerase III promoter (GO:0006385)2.43451307
161termination of RNA polymerase III transcription (GO:0006386)2.43451307
162T-helper 1 type immune response (GO:0042088)2.42742043
163protein-cofactor linkage (GO:0018065)2.42367218
164positive regulation of defense response to virus by host (GO:0002230)2.42137730
165mannosylation (GO:0097502)2.40117189
166I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.39954430
167positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.38842495
168tolerance induction (GO:0002507)2.37946860
169phagosome maturation (GO:0090382)2.36398402
170regulation of tolerance induction (GO:0002643)2.35551243
171defense response to protozoan (GO:0042832)2.34365020
172regulation of antigen processing and presentation (GO:0002577)2.34294453
173negative regulation of mast cell activation (GO:0033004)2.34204367
174neutrophil mediated immunity (GO:0002446)2.33883032
175regulation of germinal center formation (GO:0002634)2.33654133
176leukocyte degranulation (GO:0043299)2.33070292
177negative regulation of alpha-beta T cell activation (GO:0046636)2.32789281
178negative regulation of cAMP-mediated signaling (GO:0043951)2.32109866
179myeloid dendritic cell activation (GO:0001773)2.31589536
180positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.30986942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.97320318
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.91189883
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.74140287
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.49813049
5TAF15_26573619_Chip-Seq_HEK293_Human3.39334030
6GBX2_23144817_ChIP-Seq_PC3_Human2.99760753
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76095956
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.60751357
9VDR_22108803_ChIP-Seq_LS180_Human2.55703544
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.53333037
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41738306
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.39123051
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35520735
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33221920
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31127427
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.25685478
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25582655
18FUS_26573619_Chip-Seq_HEK293_Human2.21525209
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20893602
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.20716738
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.17359940
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15195846
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.07764515
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05433210
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04972622
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.03124027
27AR_21572438_ChIP-Seq_LNCaP_Human1.89765754
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.86808697
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86367636
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84594446
31ER_23166858_ChIP-Seq_MCF-7_Human1.83709123
32RNF2_27304074_Chip-Seq_NSC_Mouse1.83645477
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83597009
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81156731
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80560672
36P300_19829295_ChIP-Seq_ESCs_Human1.79096173
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75643780
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74014218
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.73327324
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72025296
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68540020
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68034796
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67497999
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65096215
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63619954
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62206868
47* VDR_23849224_ChIP-Seq_CD4+_Human1.61554711
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60075148
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60075148
50IRF1_19129219_ChIP-ChIP_H3396_Human1.60046895
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.59822190
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58961393
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51282878
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51030376
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50996409
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.50864882
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.50836871
58EWS_26573619_Chip-Seq_HEK293_Human1.50456452
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49620660
60VDR_24787735_ChIP-Seq_THP-1_Human1.48541853
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.48151301
62GATA3_26560356_Chip-Seq_TH2_Human1.47822535
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46447116
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44045638
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.44007049
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.43894870
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43742321
68BCAT_22108803_ChIP-Seq_LS180_Human1.42645791
69RUNX_20019798_ChIP-Seq_JUKART_Human1.41614940
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40907813
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40743475
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40236621
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39337600
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39332176
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.36462129
76TP53_22573176_ChIP-Seq_HFKS_Human1.36430488
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35898115
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34496761
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34082110
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34082110
81REST_21632747_ChIP-Seq_MESCs_Mouse1.33505594
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32822181
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32504668
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31414278
85SPI1_23547873_ChIP-Seq_NB4_Human1.29196733
86* GATA3_21878914_ChIP-Seq_MCF-7_Human1.28563598
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28372521
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.27727005
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27727005
90ELK1_19687146_ChIP-ChIP_HELA_Human1.26013867
91ZNF274_21170338_ChIP-Seq_K562_Hela1.25653522
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.25513638
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.25484613
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.24254928
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22778225
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.20687529
97P53_22387025_ChIP-Seq_ESCs_Mouse1.20191643
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19686211
99WT1_19549856_ChIP-ChIP_CCG9911_Human1.18056085
100SMRT_27268052_Chip-Seq_Bcells_Human1.17310743
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17252860
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16684262
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16426229
104P300_18555785_Chip-Seq_ESCs_Mouse1.15808025
105MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14921874
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.14729283
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.13781791
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13644821
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12986283
110CBP_20019798_ChIP-Seq_JUKART_Human1.12986283
111AR_20517297_ChIP-Seq_VCAP_Human1.12393608
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11843017
113ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11292907
114SMAD4_21799915_ChIP-Seq_A2780_Human1.10382866
115MYB_26560356_Chip-Seq_TH2_Human1.10310344
116HTT_18923047_ChIP-ChIP_STHdh_Human1.09541625
117FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08838648
118FOXH1_21741376_ChIP-Seq_EPCs_Human1.08671004
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08456496
120CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.08340953
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07854909
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07480004
123IGF1R_20145208_ChIP-Seq_DFB_Human1.06010021
124STAT3_18555785_Chip-Seq_ESCs_Mouse1.05458940
125MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05007882
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04538010
127CRX_20693478_ChIP-Seq_RETINA_Mouse1.04113559
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03648886
129SOX2_18555785_Chip-Seq_ESCs_Mouse1.03529517
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.02896765
131KDM2B_26808549_Chip-Seq_REH_Human1.02627093
132NANOG_19829295_ChIP-Seq_ESCs_Human1.00609930
133SOX2_19829295_ChIP-Seq_ESCs_Human1.00609930
134NMYC_18555785_Chip-Seq_ESCs_Mouse1.00513485
135* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99249752
136TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99126060
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98505949
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98464029
139JUN_21703547_ChIP-Seq_K562_Human0.98276369
140AR_25329375_ChIP-Seq_VCAP_Human0.98221320
141CDX2_22108803_ChIP-Seq_LS180_Human0.98137116
142FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97998570
143KLF4_18555785_Chip-Seq_ESCs_Mouse0.97914459
144STAT1_20625510_ChIP-Seq_HELA_Human0.97707491
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97545646
146PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97424402
147AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96914050
148RUNX2_22187159_ChIP-Seq_PCA_Human0.96305446
149GATA3_27048872_Chip-Seq_THYMUS_Human0.95886115
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95464055
151MYC_19829295_ChIP-Seq_ESCs_Human0.94577732
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.94341502
153OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92428231
154TCF4_22108803_ChIP-Seq_LS180_Human0.92317063
155SALL4_22934838_ChIP-ChIP_CD34+_Human0.91918078
156NCOR_22424771_ChIP-Seq_293T_Human0.90367045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.50743208
2MP0003724_increased_susceptibility_to3.58562413
3MP0009379_abnormal_foot_pigmentation3.26024331
4MP0003136_yellow_coat_color3.17470568
5MP0001529_abnormal_vocalization3.15524006
6MP0005409_darkened_coat_color2.93968444
7MP0005671_abnormal_response_to2.78362167
8MP0001905_abnormal_dopamine_level2.76754077
9MP0002277_abnormal_respiratory_mucosa2.60551306
10MP0000920_abnormal_myelination2.58660440
11MP0001835_abnormal_antigen_presentation2.52021741
12MP0002148_abnormal_hypersensitivity_rea2.51411020
13MP0009785_altered_susceptibility_to2.50122227
14MP0004147_increased_porphyrin_level2.39501048
15MP0005423_abnormal_somatic_nervous2.37275256
16MP0003806_abnormal_nucleotide_metabolis2.33145081
17MP0003436_decreased_susceptibility_to2.31244824
18MP0001188_hyperpigmentation2.22394430
19MP0002272_abnormal_nervous_system2.22342299
20MP0005410_abnormal_fertilization2.19518540
21MP0006082_CNS_inflammation2.18836005
22MP0004381_abnormal_hair_follicle2.18450575
23MP0002139_abnormal_hepatobiliary_system2.15809469
24MP0003195_calcinosis2.14746053
25MP0002419_abnormal_innate_immunity2.14179440
26MP0003303_peritoneal_inflammation2.12296081
27MP0004270_analgesia2.08142245
28MP0004742_abnormal_vestibular_system2.07681137
29MP0004142_abnormal_muscle_tone2.07102142
30MP0001790_abnormal_immune_system2.06989520
31MP0005387_immune_system_phenotype2.06989520
32MP0001486_abnormal_startle_reflex2.05486276
33MP0002064_seizures2.02665039
34MP0001800_abnormal_humoral_immune1.98409595
35MP0009745_abnormal_behavioral_response1.98047510
36MP0006276_abnormal_autonomic_nervous1.94003315
37MP0005000_abnormal_immune_tolerance1.92628616
38MP0001984_abnormal_olfaction1.91037675
39MP0002822_catalepsy1.89525571
40MP0002723_abnormal_immune_serum1.87350984
41MP0003635_abnormal_synaptic_transmissio1.87348043
42MP0002452_abnormal_antigen_presenting1.86940404
43MP0005551_abnormal_eye_electrophysiolog1.86618661
44MP0002734_abnormal_mechanical_nocicepti1.86015536
45MP0005025_abnormal_response_to1.84582525
46MP0002009_preneoplasia1.83398936
47MP0001440_abnormal_grooming_behavior1.82008252
48MP0005171_absent_coat_pigmentation1.81377397
49MP0002638_abnormal_pupillary_reflex1.81339319
50MP0001986_abnormal_taste_sensitivity1.80077194
51MP0000778_abnormal_nervous_system1.79725809
52MP0009046_muscle_twitch1.78005166
53MP0000685_abnormal_immune_system1.75167388
54MP0008875_abnormal_xenobiotic_pharmacok1.74156001
55MP0002572_abnormal_emotion/affect_behav1.70871420
56MP0001968_abnormal_touch/_nociception1.69884400
57MP0006292_abnormal_olfactory_placode1.68865895
58MP0003172_abnormal_lysosome_physiology1.65616842
59MP0002420_abnormal_adaptive_immunity1.65169888
60MP0001819_abnormal_immune_cell1.62806029
61MP0002102_abnormal_ear_morphology1.59842141
62MP0003011_delayed_dark_adaptation1.53360905
63MP0004859_abnormal_synaptic_plasticity1.52687412
64MP0009764_decreased_sensitivity_to1.46058198
65MP0002067_abnormal_sensory_capabilities1.45783393
66MP0003656_abnormal_erythrocyte_physiolo1.44227286
67MP0006072_abnormal_retinal_apoptosis1.43333695
68MP0002063_abnormal_learning/memory/cond1.42846823
69MP0001970_abnormal_pain_threshold1.40896687
70MP0008877_abnormal_DNA_methylation1.38992115
71MP0002163_abnormal_gland_morphology1.38968502
72MP0003718_maternal_effect1.38243524
73MP0002735_abnormal_chemical_nociception1.38194308
74MP0001845_abnormal_inflammatory_respons1.37449399
75MP0002736_abnormal_nociception_after1.36062702
76MP0002132_abnormal_respiratory_system1.34462102
77MP0001485_abnormal_pinna_reflex1.34165158
78MP0001501_abnormal_sleep_pattern1.31755670
79MP0002138_abnormal_hepatobiliary_system1.31726047
80MP0005379_endocrine/exocrine_gland_phen1.31700908
81MP0002837_dystrophic_cardiac_calcinosis1.29574931
82MP0002405_respiratory_system_inflammati1.29004919
83MP0005084_abnormal_gallbladder_morpholo1.27594667
84MP0002733_abnormal_thermal_nociception1.26126646
85MP0001963_abnormal_hearing_physiology1.25291707
86MP0002184_abnormal_innervation1.21357469
87MP0001533_abnormal_skeleton_physiology1.19985589
88MP0003950_abnormal_plasma_membrane1.19836089
89MP0002229_neurodegeneration1.19400674
90MP0008469_abnormal_protein_level1.18634229
91MP0002752_abnormal_somatic_nervous1.17301682
92MP0005310_abnormal_salivary_gland1.15281127
93MP0003787_abnormal_imprinting1.13729004
94MP0005174_abnormal_tail_pigmentation1.13416555
95MP0000566_synostosis1.12973972
96MP0002938_white_spotting1.11063814
97MP0004924_abnormal_behavior1.10296888
98MP0005386_behavior/neurological_phenoty1.10296888
99MP0000569_abnormal_digit_pigmentation1.09701491
100MP0002882_abnormal_neuron_morphology1.09253559
101MP0000026_abnormal_inner_ear1.08417371
102MP0004019_abnormal_vitamin_homeostasis1.08231138
103MP0000716_abnormal_immune_system1.07508348
104MP0003938_abnormal_ear_development1.07393322
105MP0002653_abnormal_ependyma_morphology1.04569011
106MP0008995_early_reproductive_senescence1.01893036
107MP0001853_heart_inflammation1.01241067
108MP0009840_abnormal_foam_cell0.99852828
109MP0005365_abnormal_bile_salt0.99309259
110MP0002066_abnormal_motor_capabilities/c0.97650110
111MP0002557_abnormal_social/conspecific_i0.97556026
112MP0005085_abnormal_gallbladder_physiolo0.97504415
113MP0005645_abnormal_hypothalamus_physiol0.96368030
114MP0005195_abnormal_posterior_eye0.96199818
115MP0001346_abnormal_lacrimal_gland0.95611926
116MP0000343_altered_response_to0.95470968
117MP0003879_abnormal_hair_cell0.94269487
118MP0009697_abnormal_copulation0.94105081
119MP0005646_abnormal_pituitary_gland0.94007961
120MP0002095_abnormal_skin_pigmentation0.92591012
121MP0010155_abnormal_intestine_physiology0.92447758
122MP0008569_lethality_at_weaning0.92357935
123MP0005377_hearing/vestibular/ear_phenot0.91941809
124MP0003878_abnormal_ear_physiology0.91941809
125MP0003698_abnormal_male_reproductive0.91903640
126MP0000372_irregular_coat_pigmentation0.91682117
127MP0003191_abnormal_cellular_cholesterol0.90963485
128MP0003186_abnormal_redox_activity0.89180545
129MP0005253_abnormal_eye_physiology0.89166253
130MP0000955_abnormal_spinal_cord0.88559023
131MP0001764_abnormal_homeostasis0.87894483
132MP0000631_abnormal_neuroendocrine_gland0.87876112
133MP0008789_abnormal_olfactory_epithelium0.87403106
134MP0004145_abnormal_muscle_electrophysio0.87107425
135MP0005451_abnormal_body_composition0.86548483
136MP0001324_abnormal_eye_pigmentation0.85673076
137MP0005394_taste/olfaction_phenotype0.83443447
138MP0005499_abnormal_olfactory_system0.83443447
139MP0002398_abnormal_bone_marrow0.83367127
140MP0003252_abnormal_bile_duct0.83065367
141MP0000689_abnormal_spleen_morphology0.82726846
142MP0008057_abnormal_DNA_replication0.82143668
143MP0005075_abnormal_melanosome_morpholog0.81260895
144MP0002693_abnormal_pancreas_physiology0.79937172
145MP0008872_abnormal_physiological_respon0.79512516
146MP0001851_eye_inflammation0.77891945
147MP0003634_abnormal_glial_cell0.77747211
148MP0002928_abnormal_bile_duct0.77276549
149MP0003690_abnormal_glial_cell0.76198205
150MP0001727_abnormal_embryo_implantation0.75582456
151MP0005164_abnormal_response_to0.73635177
152MP0009333_abnormal_splenocyte_physiolog0.73360083
153MP0005058_abnormal_lysosome_morphology0.73323332
154MP0003866_abnormal_defecation0.73314228
155MP0004883_abnormal_blood_vessel0.73262075
156MP0005408_hypopigmentation0.73185188
157MP0001661_extended_life_span0.73052787
158MP0002876_abnormal_thyroid_physiology0.72491649
159MP0002429_abnormal_blood_cell0.72433336
160MP0002090_abnormal_vision0.71709246
161MP0004510_myositis0.71599036
162MP0005647_abnormal_sex_gland0.68771832
163MP0003329_amyloid_beta_deposits0.68228331
164MP0003631_nervous_system_phenotype0.68010848
165MP0001502_abnormal_circadian_rhythm0.67960001
166MP0000383_abnormal_hair_follicle0.67586947
167MP0004885_abnormal_endolymph0.66962861
168MP0002152_abnormal_brain_morphology0.66689747
169MP0001340_abnormal_eyelid_morphology0.66059074
170MP0008260_abnormal_autophagy0.65557503
171MP0010386_abnormal_urinary_bladder0.65392201

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.32889045
2Parakeratosis (HP:0001036)4.18044253
3Renal Fanconi syndrome (HP:0001994)4.11317410
4Mitochondrial inheritance (HP:0001427)3.97047736
5Increased hepatocellular lipid droplets (HP:0006565)3.94824460
6Stomatitis (HP:0010280)3.89078633
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.87940115
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.87940115
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.87180518
10Progressive macrocephaly (HP:0004481)3.79552990
11Abnormal mitochondria in muscle tissue (HP:0008316)3.68494042
12Absent/shortened dynein arms (HP:0200106)3.59704836
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.59704836
14Acute encephalopathy (HP:0006846)3.43875357
15Abnormal respiratory epithelium morphology (HP:0012253)3.39568110
16Abnormal respiratory motile cilium morphology (HP:0005938)3.39568110
17Abnormality of midbrain morphology (HP:0002418)3.37159459
18Molar tooth sign on MRI (HP:0002419)3.37159459
19Pancreatic cysts (HP:0001737)3.36000252
20Lipid accumulation in hepatocytes (HP:0006561)3.35345180
21Abnormality of cells of the erythroid lineage (HP:0012130)3.35100993
223-Methylglutaconic aciduria (HP:0003535)3.28934999
23Abnormal ciliary motility (HP:0012262)3.27380850
24Optic neuritis (HP:0100653)3.13982094
25Retrobulbar optic neuritis (HP:0100654)3.13982094
26Focal motor seizures (HP:0011153)3.13859376
27Hepatocellular necrosis (HP:0001404)3.12748756
28Neurofibrillary tangles (HP:0002185)3.12200222
29Optic disc pallor (HP:0000543)3.08219552
30Increased CSF lactate (HP:0002490)3.05126117
31Abnormality of macrophages (HP:0004311)2.99930333
32Abnormality of liposaccharide metabolism (HP:0010968)2.98860265
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.98860265
34Abnormality of glycolipid metabolism (HP:0010969)2.98860265
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.97244413
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.95177216
37Abnormal respiratory motile cilium physiology (HP:0012261)2.94080592
38Recurrent bacterial skin infections (HP:0005406)2.94046230
39Abnormal hair whorl (HP:0010721)2.90678603
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.89752000
41True hermaphroditism (HP:0010459)2.88924384
42Abnormal number of erythroid precursors (HP:0012131)2.85806290
43Increased intramyocellular lipid droplets (HP:0012240)2.85667140
44Hypothermia (HP:0002045)2.84633610
45Leukodystrophy (HP:0002415)2.82567945
46Recurrent abscess formation (HP:0002722)2.81420543
47Nephronophthisis (HP:0000090)2.80659378
48Sensory axonal neuropathy (HP:0003390)2.76369169
49Abnormality of renal resorption (HP:0011038)2.76207682
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.75928164
51Congenital ichthyosiform erythroderma (HP:0007431)2.72959512
52Abnormality of the corticospinal tract (HP:0002492)2.72620147
53Orchitis (HP:0100796)2.71015948
54Increased serum pyruvate (HP:0003542)2.70596275
55Abnormality of glycolysis (HP:0004366)2.70596275
56Myositis (HP:0100614)2.69752559
57Congenital stationary night blindness (HP:0007642)2.57844425
58Hyperventilation (HP:0002883)2.56374158
59Atonic seizures (HP:0010819)2.53305219
60Recurrent gram-negative bacterial infections (HP:0005420)2.52655733
61Macrocytic anemia (HP:0001972)2.49289289
62Exertional dyspnea (HP:0002875)2.48503762
63Hypochromic microcytic anemia (HP:0004840)2.37302992
64Delusions (HP:0000746)2.37010779
65Abnormal rod and cone electroretinograms (HP:0008323)2.34201599
66Abnormality of the axillary hair (HP:0100134)2.33736499
67Abnormality of secondary sexual hair (HP:0009888)2.33736499
68Hepatic necrosis (HP:0002605)2.31745101
69Abnormality of the renal medulla (HP:0100957)2.31653395
70Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26315291
71Medial flaring of the eyebrow (HP:0010747)2.25888036
72Increased muscle lipid content (HP:0009058)2.25369497
73White forelock (HP:0002211)2.25227373
74Eczematoid dermatitis (HP:0000976)2.24385163
75Elevated erythrocyte sedimentation rate (HP:0003565)2.23852937
76Patchy hypopigmentation of hair (HP:0011365)2.23429049
77Supernumerary spleens (HP:0009799)2.22051653
78Peripheral hypomyelination (HP:0007182)2.21101472
79Chronic sinusitis (HP:0011109)2.20055455
80Thickened helices (HP:0000391)2.17232957
81Bronchiectasis (HP:0002110)2.15876298
82Abnormality of the renal cortex (HP:0011035)2.15647210
83Cerebral edema (HP:0002181)2.15246742
84Genital tract atresia (HP:0001827)2.15211661
85Rhinitis (HP:0012384)2.14282558
86Abnormal drinking behavior (HP:0030082)2.13011248
87Polydipsia (HP:0001959)2.13011248
88Myokymia (HP:0002411)2.12090769
89Vaginal atresia (HP:0000148)2.10451296
90Chronic obstructive pulmonary disease (HP:0006510)2.10338194
91Obstructive lung disease (HP:0006536)2.10338194
92Cerebral inclusion bodies (HP:0100314)2.09598936
93Abnormal pupillary function (HP:0007686)2.08475489
94Methylmalonic acidemia (HP:0002912)2.06126432
95Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.04226972
96Generalized aminoaciduria (HP:0002909)2.04137471
97Vacuolated lymphocytes (HP:0001922)2.04053419
98Septo-optic dysplasia (HP:0100842)2.03439989
99Spastic paraparesis (HP:0002313)2.03345192
100Abnormal hemoglobin (HP:0011902)2.03162541
101Respiratory difficulties (HP:0002880)2.02366156
102Cerebral hypomyelination (HP:0006808)2.02021754
103Keratoconjunctivitis sicca (HP:0001097)2.01890103
104Encephalitis (HP:0002383)2.01272361
105Bile duct proliferation (HP:0001408)2.00492948
106Abnormal biliary tract physiology (HP:0012439)2.00492948
107Hemoptysis (HP:0002105)2.00416133
108Fair hair (HP:0002286)2.00300784
109Chronic otitis media (HP:0000389)2.00236813
110Gait imbalance (HP:0002141)1.99210419
111Attenuation of retinal blood vessels (HP:0007843)1.98703075
112Chronic bronchitis (HP:0004469)1.98101177
113X-linked dominant inheritance (HP:0001423)1.96634833
114Cerebral hemorrhage (HP:0001342)1.95451061
115Cupped ear (HP:0000378)1.95239327
116Stenosis of the external auditory canal (HP:0000402)1.92529977
117Disinhibition (HP:0000734)1.92054606
118Epileptic encephalopathy (HP:0200134)1.91998165
119Stomach cancer (HP:0012126)1.91834634
120Keratoconjunctivitis (HP:0001096)1.91409103
121Amniotic constriction ring (HP:0009775)1.91197651
122Abnormality of placental membranes (HP:0011409)1.91197651
123Congenital primary aphakia (HP:0007707)1.88473173
124Recurrent fungal infections (HP:0002841)1.87904812
125Anencephaly (HP:0002323)1.87005330
126Gastrointestinal infarctions (HP:0005244)1.86824236
127Broad-based gait (HP:0002136)1.86207514
128T lymphocytopenia (HP:0005403)1.86205683
129Exercise intolerance (HP:0003546)1.86164473
130Respiratory failure (HP:0002878)1.85706315
131Retinal dysplasia (HP:0007973)1.85465203
132Metaphyseal irregularity (HP:0003025)1.85318737
133Abnormality of T cell number (HP:0011839)1.83146717
134Cystic liver disease (HP:0006706)1.82864278
135Chronic hepatic failure (HP:0100626)1.82566496
136Autoamputation (HP:0001218)1.81519030
137Pulmonary infiltrates (HP:0002113)1.81381679
138Congenital, generalized hypertrichosis (HP:0004540)1.81061539
139Hyperphosphaturia (HP:0003109)1.80783285
140Vasculitis (HP:0002633)1.80419654
141Aplasia/Hypoplasia of the tongue (HP:0010295)1.79716451
142Recurrent skin infections (HP:0001581)1.79648468
143Recurrent sinusitis (HP:0011108)1.79487111
144Mediastinal lymphadenopathy (HP:0100721)1.79217754
145Adrenal hypoplasia (HP:0000835)1.78823900
146Erythroderma (HP:0001019)1.78626880
147Congenital hepatic fibrosis (HP:0002612)1.78247951
148Progressive inability to walk (HP:0002505)1.77639857
149Dialeptic seizures (HP:0011146)1.77302653
150Abolished electroretinogram (ERG) (HP:0000550)1.76736482
151Seborrheic dermatitis (HP:0001051)1.76673473
152Nausea (HP:0002018)1.76630930
153Dysmetria (HP:0001310)1.76114786
154Paralysis (HP:0003470)1.75406718
155Nephrogenic diabetes insipidus (HP:0009806)1.75314480
156Esotropia (HP:0000565)1.72133139
157Pancreatic fibrosis (HP:0100732)1.70043137
158Absence seizures (HP:0002121)1.69351405
159Termporal pattern (HP:0011008)1.68399436
160Insidious onset (HP:0003587)1.68399436
161Absent septum pellucidum (HP:0001331)1.68014254
162Metaphyseal dysplasia (HP:0100255)1.67486184
163Lactic acidosis (HP:0003128)1.66053375
164Decreased central vision (HP:0007663)1.64852369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.71359956
2PNCK3.66395189
3TNIK3.55540387
4TAOK33.54130353
5OXSR12.81218240
6MAP3K132.77051527
7CASK2.70725211
8ACVR1B2.56814508
9MST42.55391287
10FRK2.45492977
11CDK192.12900790
12NME12.03254907
13MUSK2.03125566
14PBK1.99039178
15MAP3K121.98199435
16MAP2K71.84710946
17IRAK41.77683001
18EPHA41.73176063
19GRK71.69095966
20CSK1.66365991
21MAP4K11.65396821
22IKBKB1.64736284
23BCR1.61894282
24BLK1.61420026
25IKBKE1.60040151
26GRK51.59929814
27MAPK151.53949955
28MARK31.53658526
29BMPR1B1.51117282
30MAP3K141.49882866
31STK161.48917691
32MAP4K21.47674252
33WNK41.46620037
34TYK21.44755029
35UHMK11.43765874
36MAPKAPK51.42869104
37FGR1.41379724
38TNK21.40519615
39CSNK1G31.40308092
40MAP3K61.36875055
41FGFR21.36137306
42PKN11.35857788
43DYRK21.32077350
44MATK1.31107063
45PINK11.23349399
46EPHB11.21169741
47CDK31.20925880
48MAP3K41.20845334
49CAMK2B1.20206829
50BMPR21.19393990
51SYK1.18802992
52EIF2AK31.17401677
53TEC1.14751563
54MAPK131.13623277
55CSNK1G11.10376711
56VRK11.08903692
57ZAK1.07894489
58MAP3K91.04886657
59CSNK1G21.04763884
60RIPK41.04532984
61TBK11.03810283
62CHUK1.02683330
63KIT1.02087870
64NME21.00795768
65ADRBK20.99399616
66FES0.99110201
67CSNK1A1L0.97193081
68ARAF0.95417700
69DYRK30.93232569
70IRAK20.93018423
71CAMK2A0.92441185
72NEK60.90935801
73MAP2K40.89327876
74CAMKK20.88729798
75MAP2K60.85508129
76ROCK20.85503625
77YES10.85280256
78MAP3K110.82448780
79BCKDK0.82184494
80ITK0.81867779
81TLK10.81173603
82PIM20.80397171
83PTK2B0.78954630
84NLK0.78188734
85PIM10.75834862
86DYRK1A0.74836228
87PAK30.73883877
88GRK10.73771242
89CAMK2D0.72130077
90BTK0.71893721
91NTRK30.70849584
92CAMK2G0.70312678
93NTRK10.69963249
94LCK0.69209403
95DAPK20.69199711
96INSRR0.68455569
97JAK30.68188159
98NTRK20.64603132
99TAOK10.63649313
100CDK50.63582514
101HCK0.62748017
102PAK60.62453245
103RPS6KA50.61797732
104ZAP700.61755009
105MOS0.61271467
106RAF10.61048577
107PLK20.60802236
108IRAK10.60436658
109PRKCQ0.60081740
110EIF2AK10.59637785
111PRKCG0.59377078
112MARK10.57465666
113PRKCE0.57178968
114CDK140.56216293
115NUAK10.56034115
116SIK20.55366663
117CLK10.55141380
118CSF1R0.53978447
119PRKD20.53855545
120JAK20.53179820
121STK240.51218681
122WNK10.50903034
123PRKG10.49907365
124ADRBK10.49763306
125MYLK0.49645151
126LRRK20.49371356
127CDK11A0.47691368
128PRKACA0.47027324
129CDK150.45292095
130CDK180.44527455
131PRKCZ0.43523499
132DYRK1B0.42808046
133PASK0.42792494
134ABL20.42317069
135MKNK20.41654319
136PIK3CG0.40560950
137CAMK10.39923019
138PRKACB0.37645868
139MKNK10.37609910
140MAPK40.37592462
141STK110.37322375
142CAMK1G0.36836525
143TXK0.36660081
144MARK20.35958439
145MAP3K50.35942670
146HIPK20.34871266
147MAP3K10.34813681
148SRPK10.34786421
149LYN0.34287360
150WNK30.34096162
151ERBB40.34085186
152GRK60.33495713
153PRKCD0.32583804

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.67576594
2Parkinsons disease_Homo sapiens_hsa050123.66614246
3Ribosome_Homo sapiens_hsa030103.43375369
4Alzheimers disease_Homo sapiens_hsa050103.17931694
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.01481086
6Huntingtons disease_Homo sapiens_hsa050162.78225629
7Protein export_Homo sapiens_hsa030602.57823767
8Allograft rejection_Homo sapiens_hsa053302.55093284
9Fatty acid elongation_Homo sapiens_hsa000622.53583777
10Asthma_Homo sapiens_hsa053102.48501524
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37398214
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.35232699
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33066958
14Staphylococcus aureus infection_Homo sapiens_hsa051502.30823903
15Graft-versus-host disease_Homo sapiens_hsa053322.27666622
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.20884647
17Ether lipid metabolism_Homo sapiens_hsa005652.19788732
18Nicotine addiction_Homo sapiens_hsa050332.12453838
19Type I diabetes mellitus_Homo sapiens_hsa049402.10142038
20RNA polymerase_Homo sapiens_hsa030202.05662297
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93427218
22Proteasome_Homo sapiens_hsa030501.92273299
23Cardiac muscle contraction_Homo sapiens_hsa042601.86659419
24Leishmaniasis_Homo sapiens_hsa051401.82889764
25Collecting duct acid secretion_Homo sapiens_hsa049661.82438070
26Steroid biosynthesis_Homo sapiens_hsa001001.79864056
27Serotonergic synapse_Homo sapiens_hsa047261.79240423
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.76653426
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73968881
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73022228
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69546630
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63457652
33Phototransduction_Homo sapiens_hsa047441.62619636
34Osteoclast differentiation_Homo sapiens_hsa043801.62471154
35GABAergic synapse_Homo sapiens_hsa047271.55595870
36Basal transcription factors_Homo sapiens_hsa030221.53180026
37Glutamatergic synapse_Homo sapiens_hsa047241.48952591
38Histidine metabolism_Homo sapiens_hsa003401.45597584
39Caffeine metabolism_Homo sapiens_hsa002321.43322668
40Linoleic acid metabolism_Homo sapiens_hsa005911.42033304
41Lysosome_Homo sapiens_hsa041421.40396167
42Hematopoietic cell lineage_Homo sapiens_hsa046401.38601533
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.38219431
44Morphine addiction_Homo sapiens_hsa050321.36190850
45Tuberculosis_Homo sapiens_hsa051521.34981901
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33799266
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31244057
48Primary immunodeficiency_Homo sapiens_hsa053401.29824828
49Antigen processing and presentation_Homo sapiens_hsa046121.27195233
50Vitamin B6 metabolism_Homo sapiens_hsa007501.21567638
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20638751
52Taste transduction_Homo sapiens_hsa047421.20296713
53Sphingolipid metabolism_Homo sapiens_hsa006001.19633744
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.16554939
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.12550432
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11793050
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09992787
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08703946
59Homologous recombination_Homo sapiens_hsa034401.08090935
60Malaria_Homo sapiens_hsa051441.07002656
61Axon guidance_Homo sapiens_hsa043601.05626157
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.04115975
63Dopaminergic synapse_Homo sapiens_hsa047281.01370333
64Long-term depression_Homo sapiens_hsa047301.00718176
65Chemokine signaling pathway_Homo sapiens_hsa040620.98969006
66Circadian entrainment_Homo sapiens_hsa047130.98003453
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96344588
68Arachidonic acid metabolism_Homo sapiens_hsa005900.93860890
69Renin secretion_Homo sapiens_hsa049240.92282454
70Mineral absorption_Homo sapiens_hsa049780.91773751
71Amphetamine addiction_Homo sapiens_hsa050310.90886195
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89737566
73Sulfur metabolism_Homo sapiens_hsa009200.86640522
74Synaptic vesicle cycle_Homo sapiens_hsa047210.83535087
75Rheumatoid arthritis_Homo sapiens_hsa053230.81396701
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80489503
77Vibrio cholerae infection_Homo sapiens_hsa051100.79694236
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79321562
79Salivary secretion_Homo sapiens_hsa049700.79315297
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78465239
81Nitrogen metabolism_Homo sapiens_hsa009100.78134262
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76112169
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.72198406
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71889611
85Herpes simplex infection_Homo sapiens_hsa051680.71785025
86Measles_Homo sapiens_hsa051620.71648676
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71184816
88Legionellosis_Homo sapiens_hsa051340.70878909
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.68916115
90Butanoate metabolism_Homo sapiens_hsa006500.68906379
91Circadian rhythm_Homo sapiens_hsa047100.68746002
92Metabolic pathways_Homo sapiens_hsa011000.67334644
93Calcium signaling pathway_Homo sapiens_hsa040200.66988583
94Tyrosine metabolism_Homo sapiens_hsa003500.65516018
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63418990
96Arginine and proline metabolism_Homo sapiens_hsa003300.62067046
97Cholinergic synapse_Homo sapiens_hsa047250.61894197
98Tryptophan metabolism_Homo sapiens_hsa003800.61712046
99Cocaine addiction_Homo sapiens_hsa050300.60853709
100Pertussis_Homo sapiens_hsa051330.60498007
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59859030
102T cell receptor signaling pathway_Homo sapiens_hsa046600.59282746
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.58456685
104Long-term potentiation_Homo sapiens_hsa047200.56522884
105Glutathione metabolism_Homo sapiens_hsa004800.56069819
106TNF signaling pathway_Homo sapiens_hsa046680.54417100
107Regulation of autophagy_Homo sapiens_hsa041400.54213023
108Olfactory transduction_Homo sapiens_hsa047400.53581353
109Ovarian steroidogenesis_Homo sapiens_hsa049130.53300471
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.52559509
111Influenza A_Homo sapiens_hsa051640.51473663
112Other glycan degradation_Homo sapiens_hsa005110.51426976
113Folate biosynthesis_Homo sapiens_hsa007900.51292117
114Chemical carcinogenesis_Homo sapiens_hsa052040.51169927
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.50155898
116Ras signaling pathway_Homo sapiens_hsa040140.47715547
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47331555
118Fanconi anemia pathway_Homo sapiens_hsa034600.46537881
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46371503
120B cell receptor signaling pathway_Homo sapiens_hsa046620.45677608
121Spliceosome_Homo sapiens_hsa030400.44420982
122Peroxisome_Homo sapiens_hsa041460.43575300
123Retinol metabolism_Homo sapiens_hsa008300.43322294
124Toxoplasmosis_Homo sapiens_hsa051450.41958316
125Autoimmune thyroid disease_Homo sapiens_hsa053200.41497018
126Vitamin digestion and absorption_Homo sapiens_hsa049770.41464349
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.40081189
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39763017
129Purine metabolism_Homo sapiens_hsa002300.38865462
130Alcoholism_Homo sapiens_hsa050340.38438402
131Oxytocin signaling pathway_Homo sapiens_hsa049210.38425119
132Non-homologous end-joining_Homo sapiens_hsa034500.38325595
133Pancreatic secretion_Homo sapiens_hsa049720.38272093
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37831854
135Epstein-Barr virus infection_Homo sapiens_hsa051690.36969302
136Gastric acid secretion_Homo sapiens_hsa049710.36811000
137Pyrimidine metabolism_Homo sapiens_hsa002400.34730953
138Dorso-ventral axis formation_Homo sapiens_hsa043200.31525384
139Phenylalanine metabolism_Homo sapiens_hsa003600.30126824
140GnRH signaling pathway_Homo sapiens_hsa049120.30093516
141Melanogenesis_Homo sapiens_hsa049160.29246203
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28829887
143Viral myocarditis_Homo sapiens_hsa054160.28639185
144African trypanosomiasis_Homo sapiens_hsa051430.28490623
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27652543
146Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27591478
147Phagosome_Homo sapiens_hsa041450.27502433
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.26396218
149ABC transporters_Homo sapiens_hsa020100.24911159
150cAMP signaling pathway_Homo sapiens_hsa040240.21743162
151Insulin secretion_Homo sapiens_hsa049110.19376524
152RNA degradation_Homo sapiens_hsa030180.18719050
153Pyruvate metabolism_Homo sapiens_hsa006200.17181322

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