CILP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1extracellular fibril organization (GO:0043206)9.72057778
2keratan sulfate catabolic process (GO:0042340)9.40347709
3protein heterotrimerization (GO:0070208)8.62211823
4fibril organization (GO:0097435)8.32505037
5peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)7.32947403
6collagen fibril organization (GO:0030199)6.74508817
7sequestering of extracellular ligand from receptor (GO:0035581)6.32172424
8extracellular matrix assembly (GO:0085029)5.79963384
9dermatan sulfate biosynthetic process (GO:0030208)5.66134252
10bone trabecula formation (GO:0060346)5.48947779
11dermatan sulfate metabolic process (GO:0030205)5.17277429
12positive regulation of osteoblast proliferation (GO:0033690)5.02032459
13low-density lipoprotein particle clearance (GO:0034383)4.87717739
14collagen metabolic process (GO:0032963)4.87567051
15growth hormone secretion (GO:0030252)4.67452072
16multicellular organismal macromolecule metabolic process (GO:0044259)4.65663847
17collagen catabolic process (GO:0030574)4.61409092
18atrioventricular valve morphogenesis (GO:0003181)4.53437423
19regulation of sequestering of triglyceride (GO:0010889)4.48341942
20multicellular organismal metabolic process (GO:0044236)4.45299323
21multicellular organismal catabolic process (GO:0044243)4.32172170
22negative regulation of biomineral tissue development (GO:0070168)4.31623565
23keratan sulfate biosynthetic process (GO:0018146)4.19007508
24peripheral nervous system axon ensheathment (GO:0032292)4.05579288
25myelination in peripheral nervous system (GO:0022011)4.05579288
26triglyceride catabolic process (GO:0019433)4.03860321
27positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.03503336
28glomerulus development (GO:0032835)4.01701980
29endocardial cushion morphogenesis (GO:0003203)3.99514664
30myoblast migration (GO:0051451)3.99148640
31venous blood vessel morphogenesis (GO:0048845)3.97658279
32extracellular matrix disassembly (GO:0022617)3.97579867
33skeletal muscle adaptation (GO:0043501)3.95790183
34negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.89205403
35barbed-end actin filament capping (GO:0051016)3.84871593
36plasma membrane repair (GO:0001778)3.82829451
37sulfur compound catabolic process (GO:0044273)3.82298861
38detection of molecule of bacterial origin (GO:0032490)3.79705533
39skin morphogenesis (GO:0043589)3.78643232
40negative regulation of heart growth (GO:0061117)3.72015235
41negative regulation of cardiac muscle tissue growth (GO:0055022)3.72015235
42metanephric mesenchyme development (GO:0072075)3.69761326
43endodermal cell differentiation (GO:0035987)3.68663991
44regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.66382795
45regulation of cardiac muscle cell apoptotic process (GO:0010665)3.65318127
46cellular response to epinephrine stimulus (GO:0071872)3.64809805
47opsonization (GO:0008228)3.64579731
48vocalization behavior (GO:0071625)3.64301858
49keratan sulfate metabolic process (GO:0042339)3.61536433
50cardiac myofibril assembly (GO:0055003)3.59562407
51regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.59448491
52epithelial cell-cell adhesion (GO:0090136)3.59322109
53neutral lipid catabolic process (GO:0046461)3.58510201
54acylglycerol catabolic process (GO:0046464)3.58510201
55chondroitin sulfate catabolic process (GO:0030207)3.57932435
56regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.56415067
57myofibril assembly (GO:0030239)3.56040711
58endothelial cell morphogenesis (GO:0001886)3.55510250
59fatty acid transmembrane transport (GO:1902001)3.50650114
60extracellular matrix organization (GO:0030198)3.50513204
61extracellular structure organization (GO:0043062)3.49061559
62vascular endothelial growth factor signaling pathway (GO:0038084)3.45597648
63positive regulation of blood vessel endothelial cell migration (GO:0043536)3.41959761
64growth hormone receptor signaling pathway (GO:0060396)3.40304671
65gonadal mesoderm development (GO:0007506)3.38332456
66insulin-like growth factor receptor signaling pathway (GO:0048009)3.35492308
67cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.34625910
68regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.34584461
69regulation of striated muscle cell apoptotic process (GO:0010662)3.29563386
70negative regulation of stress fiber assembly (GO:0051497)3.28431453
71camera-type eye morphogenesis (GO:0048593)3.27751064
72carnitine shuttle (GO:0006853)3.27691725
73cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.27223652
74regulation of cAMP-dependent protein kinase activity (GO:2000479)3.23924013
75extracellular negative regulation of signal transduction (GO:1900116)3.22975472
76extracellular regulation of signal transduction (GO:1900115)3.22975472
77oxygen transport (GO:0015671)3.21935819
78ovulation from ovarian follicle (GO:0001542)3.20940192
79trabecula formation (GO:0060343)3.20814947
80mesenchyme morphogenesis (GO:0072132)3.20558708
81negative regulation of Rho protein signal transduction (GO:0035024)3.19979159
82endocrine hormone secretion (GO:0060986)3.18833078
83kidney mesenchyme development (GO:0072074)3.18182582
84protein trimerization (GO:0070206)3.16674839
85positive regulation of cholesterol efflux (GO:0010875)3.15337187
86glycosaminoglycan catabolic process (GO:0006027)3.14476688
87regulation of cardiac muscle cell differentiation (GO:2000725)3.14068029
88positive regulation of glycogen biosynthetic process (GO:0045725)3.13416504
89positive regulation of Rho protein signal transduction (GO:0035025)3.13154823
90cellular response to growth hormone stimulus (GO:0071378)3.13000755
91glomerular basement membrane development (GO:0032836)3.11687609
92response to epinephrine (GO:0071871)3.11542049
93actin-myosin filament sliding (GO:0033275)3.09769244
94muscle filament sliding (GO:0030049)3.09769244
95regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.07327990
96regulation of plasminogen activation (GO:0010755)3.05351607
97muscle cell migration (GO:0014812)3.04635410
98cell migration involved in heart development (GO:0060973)3.04305236
99peptide cross-linking (GO:0018149)3.03898821
100regulation of macrophage cytokine production (GO:0010935)3.03791747
101regulation of cardiac muscle hypertrophy (GO:0010611)3.03008016
102muscle hypertrophy (GO:0014896)3.02769251
103behavioral response to pain (GO:0048266)2.99957989
104regulation of muscle hypertrophy (GO:0014743)2.97368386
105creatine metabolic process (GO:0006600)2.97360217
106negative regulation of smooth muscle cell migration (GO:0014912)2.96880260
107fatty acid homeostasis (GO:0055089)2.96720430
108protein retention in ER lumen (GO:0006621)2.96483996
109polyol transport (GO:0015791)2.96115670
110ethanol oxidation (GO:0006069)2.95920674
111retina vasculature morphogenesis in camera-type eye (GO:0061299)2.95780108
112positive regulation of fatty acid oxidation (GO:0046321)2.94063725
113adhesion of symbiont to host cell (GO:0044650)2.93481142
114virion attachment to host cell (GO:0019062)2.93481142
115substrate-dependent cell migration (GO:0006929)2.92972753
116chondroitin sulfate biosynthetic process (GO:0030206)2.92377342
117aminoglycan catabolic process (GO:0006026)2.90771763
118fibroblast migration (GO:0010761)2.90043884
119basement membrane organization (GO:0071711)2.88895951
120negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.87181527
121positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.86410234
122NADH metabolic process (GO:0006734)2.86054245
123regulation of p38MAPK cascade (GO:1900744)2.85238885
124cGMP-mediated signaling (GO:0019934)2.84936576
125glomerular filtration (GO:0003094)2.82728353
126epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.82590226
127regulation of cholesterol storage (GO:0010885)2.80451475
128complement activation, alternative pathway (GO:0006957)2.80027445
129positive regulation of glucose import (GO:0046326)2.77161417
130regulation of interleukin-8 secretion (GO:2000482)2.77034359
131striated muscle hypertrophy (GO:0014897)2.76929520
132cellular response to BMP stimulus (GO:0071773)2.76722052
133response to BMP (GO:0071772)2.76722052
134positive regulation of glomerulus development (GO:0090193)2.76700031
135maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.75696189
136glycosaminoglycan biosynthetic process (GO:0006024)2.74866688
137actin-mediated cell contraction (GO:0070252)2.74798521
138regulation of skeletal muscle contraction (GO:0014819)2.74416207
139regulation of phospholipase A2 activity (GO:0032429)2.73420862
140blood vessel maturation (GO:0001955)2.72794876
141aminoglycan biosynthetic process (GO:0006023)2.72428904
142adhesion of symbiont to host (GO:0044406)2.72250721
143positive regulation of smooth muscle cell migration (GO:0014911)2.71005975
144negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.70920903
145chondrocyte proliferation (GO:0035988)2.69229964
146non-canonical Wnt signaling pathway (GO:0035567)2.68828974
147negative regulation of granulocyte differentiation (GO:0030853)2.68567037
148negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)2.68493088
149regulation of SMAD protein import into nucleus (GO:0060390)2.68140690
150arginine catabolic process (GO:0006527)2.67472737
151positive regulation of glycolytic process (GO:0045821)2.66056550
152positive regulation of lipid storage (GO:0010884)2.65094249
153valine metabolic process (GO:0006573)2.64955327
154phagocytosis, recognition (GO:0006910)2.64781292
155negative regulation of gluconeogenesis (GO:0045721)2.64485819
156positive regulation of sterol transport (GO:0032373)2.63336295
157positive regulation of cholesterol transport (GO:0032376)2.63336295
158protein localization to cell surface (GO:0034394)2.62444632
159regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.60447300
160actin filament-based movement (GO:0030048)2.60443995
161apoptotic cell clearance (GO:0043277)2.57384385
162positive regulation of p38MAPK cascade (GO:1900745)2.54312078
163skeletal muscle contraction (GO:0003009)2.51517508
164sarcoplasmic reticulum calcium ion transport (GO:0070296)2.50625569
165glycerolipid catabolic process (GO:0046503)2.49433011
166renal filtration (GO:0097205)2.48977789
167sarcomere organization (GO:0045214)2.47397145
168negative regulation of smooth muscle cell proliferation (GO:0048662)2.45784833
169positive regulation of metanephros development (GO:0072216)2.44724596
170regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.43961779
171striated muscle adaptation (GO:0014888)2.43034823
172regulation of muscle adaptation (GO:0043502)2.42388759
173regulation of smooth muscle cell migration (GO:0014910)2.42357889
174regulation of macrophage derived foam cell differentiation (GO:0010743)2.41395063
175transcytosis (GO:0045056)2.39652930
176lipid storage (GO:0019915)2.39395014

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.47699274
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.23562433
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.03446829
4ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.91932697
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.86414480
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.85915102
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.83927409
8CJUN_26792858_Chip-Seq_BT549_Human2.75080861
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.55016613
10CLOCK_20551151_ChIP-Seq_293T_Human2.45364252
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.30243042
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.29873653
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.21729436
14CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.09286608
15AR_21572438_ChIP-Seq_LNCaP_Human2.08968426
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.08393103
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.03207368
18EZH2_22144423_ChIP-Seq_EOC_Human1.90714752
19RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.89705311
20WT1_19549856_ChIP-ChIP_CCG9911_Human1.89333761
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88185545
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.82163853
23BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.79056337
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.74700226
25DROSHA_22980978_ChIP-Seq_HELA_Human1.66495611
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62894797
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62606744
28BRD4_25478319_ChIP-Seq_HGPS_Human1.56297709
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53363826
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53156222
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53156222
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51840134
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48013005
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44271018
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44271018
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42710386
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.41890398
38NFIB_24661679_ChIP-Seq_LUNG_Mouse1.41746900
39* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40420430
40JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40341219
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39524643
42TBX20_22080862_ChIP-Seq_HEART_Mouse1.38045731
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.38045731
44TP53_18474530_ChIP-ChIP_U2OS_Human1.38039048
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37190248
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36568490
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35269115
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33784532
49JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32057993
50* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30772967
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.27163985
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25456204
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21223932
54PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18629181
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16413131
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15541009
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.15418935
58EGR1_19032775_ChIP-ChIP_M12_Human1.15221604
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15216538
60SOX2_20726797_ChIP-Seq_SW620_Human1.14939199
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13003229
62AHR_22903824_ChIP-Seq_MCF-7_Human1.12404151
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11953251
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11703427
65GATA1_22025678_ChIP-Seq_K562_Human1.11312785
66ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10161439
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09306013
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08855271
69* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08475916
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.07802035
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07771612
72NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06880306
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05990262
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05896949
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04465936
76PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.04269005
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.03623120
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03542622
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03407596
80TP53_16413492_ChIP-PET_HCT116_Human1.03172602
81SA1_22415368_ChIP-Seq_MEFs_Mouse1.02887373
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02616204
83* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02231210
84GBX2_23144817_ChIP-Seq_PC3_Human1.00835680
85SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99634921
86HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99426417
87P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98086595
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97689466
89ISL1_27105846_Chip-Seq_CPCs_Mouse0.97623517
90EZH2_27304074_Chip-Seq_ESCs_Mouse0.96949198
91SMAD3_21741376_ChIP-Seq_HESCs_Human0.94990984
92MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94305050
93LXR_22158963_ChIP-Seq_LIVER_Mouse0.93729784
94CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92675364
95TCF4_18268006_ChIP-ChIP_LS174T_Human0.92478666
96P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92001694
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91846145
98ZNF263_19887448_ChIP-Seq_K562_Human0.90930305
99SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90589455
100FOXA2_19822575_ChIP-Seq_HepG2_Human0.89663377
101EZH2_27294783_Chip-Seq_ESCs_Mouse0.89308850
102CSB_26484114_Chip-Seq_FIBROBLAST_Human0.89110010
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88157515
104SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88157515
105RNF2_27304074_Chip-Seq_ESCs_Mouse0.88122700
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87899259
107FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87863614
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87209034
109ELK3_25401928_ChIP-Seq_HUVEC_Human0.86860990
110WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86792371
111UBF1/2_26484160_Chip-Seq_HMECs_Human0.86785051
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86341726
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86275786
114* TP63_23658742_ChIP-Seq_EP156T_Human0.85522963
115KDM2B_26808549_Chip-Seq_K562_Human0.83838022
116RXR_22158963_ChIP-Seq_LIVER_Mouse0.83250708
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.81963852
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.81749159
119RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80306226
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80239229
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.79946467
122SMAD4_21799915_ChIP-Seq_A2780_Human0.78976697
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.78957861
124RING1B_27294783_Chip-Seq_ESCs_Mouse0.78866365
125VDR_24787735_ChIP-Seq_THP-1_Human0.78395839
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78299170
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.78151047
128SUZ12_27294783_Chip-Seq_ESCs_Mouse0.77547321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology8.55141856
2MP0005275_abnormal_skin_tensile8.52867688
3MP0005670_abnormal_white_adipose4.30764381
4MP0001958_emphysema3.59037079
5MP0003705_abnormal_hypodermis_morpholog2.98957906
6MP0002108_abnormal_muscle_morphology2.87602044
7MP0003279_aneurysm2.75553866
8MP0005666_abnormal_adipose_tissue2.66155704
9MP0005257_abnormal_intraocular_pressure2.48636557
10MP0002060_abnormal_skin_morphology2.46782606
11MP0000751_myopathy2.42081648
12MP0001661_extended_life_span2.24789783
13MP0005375_adipose_tissue_phenotype2.05991568
14MP0005508_abnormal_skeleton_morphology2.02506115
15MP0008438_abnormal_cutaneous_collagen10.6568862
16MP0004272_abnormal_basement_membrane1.96357807
17MP0006054_spinal_hemorrhage1.87728114
18MP0005171_absent_coat_pigmentation1.76437434
19MP0002971_abnormal_brown_adipose1.70951114
20MP0003566_abnormal_cell_adhesion1.70257560
21MP0010368_abnormal_lymphatic_system1.70221893
22MP0003283_abnormal_digestive_organ1.64055867
23MP0000749_muscle_degeneration1.56125167
24MP0002837_dystrophic_cardiac_calcinosis1.55642770
25MP0009384_cardiac_valve_regurgitation1.47808096
26MP0002295_abnormal_pulmonary_circulatio1.45171895
27MP0009115_abnormal_fat_cell1.36506507
28MP0004134_abnormal_chest_morphology1.34548100
29MP0001243_abnormal_dermal_layer1.34334738
30MP0005369_muscle_phenotype1.32521671
31MP0002933_joint_inflammation1.24039219
32MP0004185_abnormal_adipocyte_glucose1.19076284
33MP0004145_abnormal_muscle_electrophysio1.17838908
34MP0005390_skeleton_phenotype1.16349938
35MP0002638_abnormal_pupillary_reflex1.13547391
36MP0009780_abnormal_chondrocyte_physiolo1.13190840
37MP0001542_abnormal_bone_strength1.13100459
38MP0009250_abnormal_appendicular_skeleto1.11274049
39MP0002876_abnormal_thyroid_physiology1.10458943
40MP0005330_cardiomyopathy1.06820673
41MP0003959_abnormal_lean_body1.05642858
42MP0000750_abnormal_muscle_regeneration1.01438192
43MP0000747_muscle_weakness0.98570493
44MP0003646_muscle_fatigue0.97272027
45MP0004087_abnormal_muscle_fiber0.95955464
46MP0002106_abnormal_muscle_physiology0.95360698
47MP0002254_reproductive_system_inflammat0.94548113
48MP0005023_abnormal_wound_healing0.94247804
49MP0000343_altered_response_to0.92707812
50MP0010386_abnormal_urinary_bladder0.91936422
51MP0003252_abnormal_bile_duct0.89078713
52MP0003724_increased_susceptibility_to0.88556447
53MP0000759_abnormal_skeletal_muscle0.88276137
54MP0002970_abnormal_white_adipose0.83268913
55MP0003045_fibrosis0.83008200
56MP0005334_abnormal_fat_pad0.82515108
57MP0010329_abnormal_lipoprotein_level0.82268302
58MP0005620_abnormal_muscle_contractility0.81215813
59MP0005595_abnormal_vascular_smooth0.77075912
60MP0002168_other_aberrant_phenotype0.76479621
61MP0002282_abnormal_trachea_morphology0.74713553
62MP0000163_abnormal_cartilage_morphology0.74297209
63MP0002127_abnormal_cardiovascular_syste0.72700854
64MP0005535_abnormal_body_temperature0.72240591
65MP0002133_abnormal_respiratory_system0.71812142
66MP0005388_respiratory_system_phenotype0.71812142
67MP0001544_abnormal_cardiovascular_syste0.70082864
68MP0005385_cardiovascular_system_phenoty0.70082864
69MP0010771_integument_phenotype0.68594721
70MP0004215_abnormal_myocardial_fiber0.68033235
71MP0003448_altered_tumor_morphology0.67688198
72MP0000733_abnormal_muscle_development0.67224574
73MP0004084_abnormal_cardiac_muscle0.67125774
74MP0000249_abnormal_blood_vessel0.66260718
75MP0002972_abnormal_cardiac_muscle0.66202033
76MP0005623_abnormal_meninges_morphology0.65260890
77MP0002896_abnormal_bone_mineralization0.64727835
78MP0002998_abnormal_bone_remodeling0.64403019
79MP0004036_abnormal_muscle_relaxation0.63868796
80MP0005167_abnormal_blood-brain_barrier0.63780195
81MP0002115_abnormal_skeleton_extremities0.63628276
82MP0001533_abnormal_skeleton_physiology0.63076859
83MP0004858_abnormal_nervous_system0.62408741
84MP0002128_abnormal_blood_circulation0.61366826
85MP0003115_abnormal_respiratory_system0.61285379
86MP0005165_increased_susceptibility_to0.61281611
87MP0002118_abnormal_lipid_homeostasis0.60887853
88MP0004130_abnormal_muscle_cell0.60727964
89MP0000767_abnormal_smooth_muscle0.60520176
90MP0004484_altered_response_of0.60335696
91MP0000013_abnormal_adipose_tissue0.59815212
92MP0003868_abnormal_feces_composition0.59487041
93MP0001299_abnormal_eye_distance/0.57456091
94MP0005448_abnormal_energy_balance0.57113021
95MP0006138_congestive_heart_failure0.56462825
96MP0003948_abnormal_gas_homeostasis0.55805906
97MP0003950_abnormal_plasma_membrane0.55702285
98MP0002113_abnormal_skeleton_development0.55278128
99MP0003191_abnormal_cellular_cholesterol0.55190084
100MP0002932_abnormal_joint_morphology0.55000108
101MP0005164_abnormal_response_to0.54648083
102MP0003075_altered_response_to0.54390643
103MP0002332_abnormal_exercise_endurance0.54341108
104MP0004883_abnormal_blood_vessel0.53575060
105MP0008004_abnormal_stomach_pH0.53375859
106MP0002269_muscular_atrophy0.52775266
107MP0003385_abnormal_body_wall0.52472226
108MP0000534_abnormal_ureter_morphology0.51722509
109MP0002166_altered_tumor_susceptibility0.50125537
110MP0005220_abnormal_exocrine_pancreas0.49618551
111MP0000230_abnormal_systemic_arterial0.49510578
112MP0001175_abnormal_lung_morphology0.49488704
113MP0000003_abnormal_adipose_tissue0.49435224
114MP0008775_abnormal_heart_ventricle0.49429884
115MP0010630_abnormal_cardiac_muscle0.49331718
116MP0003795_abnormal_bone_structure0.48529249
117MP0001879_abnormal_lymphatic_vessel0.48183367
118MP0003091_abnormal_cell_migration0.47389431
119MP0003828_pulmonary_edema0.43577826
120MP0002006_tumorigenesis0.42747190
121MP0001614_abnormal_blood_vessel0.42320285
122MP0001177_atelectasis0.41315926
123MP0000266_abnormal_heart_morphology0.41184035
124MP0005166_decreased_susceptibility_to0.39655715
125MP0009931_abnormal_skin_appearance0.37877762
126MP0005193_abnormal_anterior_eye0.37399063
127MP0005076_abnormal_cell_differentiation0.36905759

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)9.10650850
2Broad metatarsal (HP:0001783)6.86121547
3Premature rupture of membranes (HP:0001788)6.53103921
4Type 1 muscle fiber predominance (HP:0003803)5.46605066
5Increased connective tissue (HP:0009025)5.21419030
6Aortic dissection (HP:0002647)4.89787219
7Ankle contracture (HP:0006466)4.89725587
8Soft skin (HP:0000977)4.61827324
9Shallow orbits (HP:0000586)4.48608576
10Round ear (HP:0100830)4.48456864
11Aortic aneurysm (HP:0004942)4.27475186
12Follicular hyperkeratosis (HP:0007502)4.26973090
13Bladder diverticulum (HP:0000015)4.17672624
14Cerebral aneurysm (HP:0004944)4.14449379
15Dilatation of the ascending aorta (HP:0005111)4.12972027
16Flat cornea (HP:0007720)3.97317635
17Striae distensae (HP:0001065)3.80591780
18Spinal rigidity (HP:0003306)3.78894043
19Slender build (HP:0001533)3.70669854
20Mitral valve prolapse (HP:0001634)3.69459423
21Oligomenorrhea (HP:0000876)3.68027525
22Atrophic scars (HP:0001075)3.64392622
23Muscle fiber splitting (HP:0003555)3.56298136
24Mildly elevated creatine phosphokinase (HP:0008180)3.56122900
25Fragile skin (HP:0001030)3.52731491
26Increased variability in muscle fiber diameter (HP:0003557)3.44004956
27Thin bony cortex (HP:0002753)3.37954894
28Spondylolisthesis (HP:0003302)3.35927537
29Mitral stenosis (HP:0001718)3.33436293
30Neonatal short-limb short stature (HP:0008921)3.30140419
31Vertebral compression fractures (HP:0002953)3.27602191
32Subacute progressive viral hepatitis (HP:0006572)3.24378992
33Genu recurvatum (HP:0002816)3.23197383
34Abnormality of skeletal muscle fiber size (HP:0012084)3.20784035
35Wormian bones (HP:0002645)2.98378397
36Broad ribs (HP:0000885)2.97244902
37Hyperextensible skin (HP:0000974)2.96918014
38Pulmonary artery stenosis (HP:0004415)2.96589855
39Wrist flexion contracture (HP:0001239)2.95505620
40Biconcave vertebral bodies (HP:0004586)2.92630392
41Abnormal delivery (HP:0001787)2.85916517
42Peritonitis (HP:0002586)2.85195820
43Blue sclerae (HP:0000592)2.85137810
44Spinal cord compression (HP:0002176)2.85088026
45Overgrowth (HP:0001548)2.83849670
46Neck muscle weakness (HP:0000467)2.75669791
47Abnormality of complement system (HP:0005339)2.75095895
48Mitral regurgitation (HP:0001653)2.72912868
49Mild short stature (HP:0003502)2.70044291
50Hypoplasia of the iris (HP:0007676)2.66268811
51Asymmetric septal hypertrophy (HP:0001670)2.65628486
52Joint stiffness (HP:0001387)2.63925351
53Cervical subluxation (HP:0003308)2.62881369
54Vascular tortuosity (HP:0004948)2.60973788
55Muscle fiber inclusion bodies (HP:0100299)2.59719076
56Ectopia lentis (HP:0001083)2.58840170
57Aortic valve stenosis (HP:0001650)2.57468541
58Alopecia of scalp (HP:0002293)2.53653817
59Right ventricular cardiomyopathy (HP:0011663)2.50709221
60Abnormality of the calf musculature (HP:0001430)2.48285914
61Small epiphyses (HP:0010585)2.48123847
62Joint laxity (HP:0001388)2.47294489
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.47015061
64Osteolytic defects of the hand bones (HP:0009699)2.47015061
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.46792981
66Bulbar palsy (HP:0001283)2.44575757
67Exercise-induced myalgia (HP:0003738)2.43236426
68Calf muscle hypertrophy (HP:0008981)2.42430239
69Disproportionate tall stature (HP:0001519)2.41614203
70Infantile muscular hypotonia (HP:0008947)2.37491622
71Abnormality of dentin (HP:0010299)2.37221590
72Myotonia (HP:0002486)2.35898845
73Aortic regurgitation (HP:0001659)2.35830255
74Camptodactyly of toe (HP:0001836)2.34632303
75Acanthosis nigricans (HP:0000956)2.34617893
76Decreased subcutaneous fat (HP:0001002)2.30597635
77Aneurysm (HP:0002617)2.29242688
78Muscle hypertrophy of the lower extremities (HP:0008968)2.28203265
79Generalized amyotrophy (HP:0003700)2.27435832
80Rimmed vacuoles (HP:0003805)2.26809865
81Arterial tortuosity (HP:0005116)2.26321520
82Beaking of vertebral bodies (HP:0004568)2.24956464
83Lipoatrophy (HP:0100578)2.22951235
84Hyporeflexia of lower limbs (HP:0002600)2.22493515
85Neoplasm of head and neck (HP:0012288)2.21049973
86Esophageal neoplasm (HP:0100751)2.21049973
87Abnormality of the acetabulum (HP:0003170)2.20582778
88Sudden death (HP:0001699)2.20459763
89Nemaline bodies (HP:0003798)2.18637849
90Scapular winging (HP:0003691)2.18631371
91Exercise-induced muscle cramps (HP:0003710)2.18527654
92Bowel diverticulosis (HP:0005222)2.16118527
93Ovoid vertebral bodies (HP:0003300)2.15854034
94Redundant skin (HP:0001582)2.15407650
95Systemic lupus erythematosus (HP:0002725)2.14630287
96Cardiovascular calcification (HP:0011915)2.14440062
97Emphysema (HP:0002097)2.13138431
98Rectal prolapse (HP:0002035)2.12399016
99Abnormality of the ischium (HP:0003174)2.11893449
100Osteoarthritis (HP:0002758)2.10557356
101Limited hip movement (HP:0008800)2.09761232
102EMG: myopathic abnormalities (HP:0003458)2.06030840
103Elbow flexion contracture (HP:0002987)2.03651856
104Proximal amyotrophy (HP:0007126)2.03435165
105Ulnar deviation of the wrist (HP:0003049)2.02341735
106Ventricular tachycardia (HP:0004756)2.00194079
107Hip contracture (HP:0003273)1.99418148
108Broad palm (HP:0001169)1.99171933
109Lymphangioma (HP:0100764)1.98867417
110Wide anterior fontanel (HP:0000260)1.96906969
111Hypoplasia of the odontoid process (HP:0003311)1.96522405
112Distal lower limb amyotrophy (HP:0008944)1.94714567
113Venous abnormality (HP:0002624)1.91831906
114Abnormality of the anterior chamber (HP:0000593)1.91602581
115Difficulty running (HP:0009046)1.87157903
116Distal arthrogryposis (HP:0005684)1.86793963
117Amyloidosis (HP:0011034)1.86556575
118Irregular vertebral endplates (HP:0003301)1.86343918
119Delayed closure of the anterior fontanelle (HP:0001476)1.85846142
120Venous insufficiency (HP:0005293)1.84828633
121Gowers sign (HP:0003391)1.83886161
122Breech presentation (HP:0001623)1.83302448
123Myopathic facies (HP:0002058)1.83108092
124Narrow nasal bridge (HP:0000446)1.82643180
125Calcaneovalgus deformity (HP:0001848)1.81496821
126Frequent falls (HP:0002359)1.81005090
127Complement deficiency (HP:0004431)1.80157592
128Distal lower limb muscle weakness (HP:0009053)1.78118715
129Limb-girdle muscle weakness (HP:0003325)1.76727969
130Joint contractures involving the joints of the feet (HP:0100492)1.75200933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.84029332
2TTN4.01433620
3TGFBR23.48351697
4EPHA32.74530206
5DDR22.69658280
6PDGFRA2.59231961
7STK242.58997292
8SIK12.54355481
9ERN12.42261922
10TIE12.36943220
11EEF2K2.26041377
12EPHB12.21232975
13TRIB32.20081191
14MAP3K62.13313695
15STK38L2.12853925
16PRKCH2.11914172
17FER2.03960887
18MST1R1.94609172
19STK31.93999764
20PRKD21.93312734
21ERBB31.85472616
22NEK91.81499853
23PRKAA21.79486224
24MAPKAPK31.65993988
25LATS21.65934345
26PHKG11.64476495
27PHKG21.64476495
28FGFR41.55767225
29BCKDK1.45181388
30PIK3CA1.44930576
31BMPR21.41185414
32DMPK1.37186511
33PRPF4B1.31938721
34FRK1.31810963
35PIK3CG1.28249265
36LATS11.26395464
37MUSK1.23069618
38CDC42BPA1.19751794
39PDK21.19084365
40JAK11.17611211
41PINK11.17329238
42RIPK11.16803426
43MAPK71.09717541
44ICK1.09591729
45ZAK1.06538734
46MARK21.06263950
47MAPK41.03694867
48INSRR1.02797547
49PAK21.02657092
50PKN21.00573286
51SGK20.99725550
52MYLK0.99667778
53PDK40.98602667
54PDK30.98602667
55MAP3K70.98334172
56BLK0.97340827
57TRPM70.95238176
58MAP3K30.94334535
59FGFR30.94252101
60PRKAA10.90948347
61CAMK10.88942289
62PLK20.88572132
63SGK30.86296897
64BMX0.86040646
65EPHB20.85618459
66PTK2B0.84812948
67PDGFRB0.83839460
68ILK0.83539164
69PTK60.83057938
70PRKCE0.82356795
71RPS6KA20.81563260
72IRAK10.80919682
73GSK3A0.80692911
74WNK10.80422495
75MET0.79790210
76TESK10.78363858
77PRKD10.75376526
78PAK30.74878966
79SGK2230.73859282
80SGK4940.73859282
81LMTK20.70646095
82MAP2K30.70394215
83ROCK10.69913758
84PIM20.69554153
85LRRK20.67940871
86KIT0.67895714
87NLK0.66255150
88MAP2K40.65940978
89STK380.59875889
90NME10.58141362
91AKT30.57842048
92MAP2K10.57299171
93CAMK40.55418551
94RPS6KL10.53894526
95RPS6KC10.53894526
96JAK20.53335919
97MAP3K20.52506451
98TYK20.51461523
99KDR0.50643413
100MARK10.49622979
101FGFR10.48525644
102PKN10.47149992
103CLK10.46886737
104IRAK40.46010299
105PRKACG0.45152415
106RPS6KA60.44980021
107MAPK150.44673658
108AKT20.43858689
109ROCK20.42250233
110MAPK30.41472042
111INSR0.41434225
112TGFBR10.41385077
113ERBB40.40960633
114JAK30.40692877
115IKBKB0.39202826
116RET0.38827583
117PDPK10.38413046
118MTOR0.37921570
119CSK0.37833402
120MOS0.37083056
121PAK40.36849397
122HIPK20.35709557
123MAP3K110.34628947
124RPS6KA30.33749114
125CDK60.33558105
126IGF1R0.31647110
127PRKACB0.31547514
128PRKG10.31272913
129CAMK2G0.31240661
130ABL20.31060826
131PTK20.30917693
132MAP3K10.30434288
133MAPK120.30033698
134SRC0.29254954
135ABL10.29211071
136ADRBK10.28563116
137STK390.25101203
138NTRK10.25046342
139MAPK10.21625064
140MAPKAPK50.21555755

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.00473359
2Protein digestion and absorption_Homo sapiens_hsa049743.64762388
3Malaria_Homo sapiens_hsa051443.51390059
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.20509182
5Dilated cardiomyopathy_Homo sapiens_hsa054143.06738604
6Focal adhesion_Homo sapiens_hsa045102.82432508
7Amoebiasis_Homo sapiens_hsa051462.42171465
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.41359395
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.15182861
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.02547946
11Tyrosine metabolism_Homo sapiens_hsa003501.88757666
12Phenylalanine metabolism_Homo sapiens_hsa003601.78906965
13Starch and sucrose metabolism_Homo sapiens_hsa005001.72438331
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.64653417
15ABC transporters_Homo sapiens_hsa020101.63456478
16TGF-beta signaling pathway_Homo sapiens_hsa043501.61236145
17Fatty acid biosynthesis_Homo sapiens_hsa000611.58372455
18Proteoglycans in cancer_Homo sapiens_hsa052051.53386441
19PI3K-Akt signaling pathway_Homo sapiens_hsa041511.46363444
20Viral myocarditis_Homo sapiens_hsa054161.41874275
21Prion diseases_Homo sapiens_hsa050201.40582934
22Complement and coagulation cascades_Homo sapiens_hsa046101.40116948
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.27158246
24Insulin resistance_Homo sapiens_hsa049311.23467198
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18525819
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16616493
27Toxoplasmosis_Homo sapiens_hsa051451.15885686
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09976979
29Glycerolipid metabolism_Homo sapiens_hsa005611.08793659
30Adherens junction_Homo sapiens_hsa045201.07022183
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04987270
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.02328120
33Histidine metabolism_Homo sapiens_hsa003401.01592718
34Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98923885
35Galactose metabolism_Homo sapiens_hsa000520.97422531
36Small cell lung cancer_Homo sapiens_hsa052220.97417946
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91028965
38Platelet activation_Homo sapiens_hsa046110.86989706
39Chronic myeloid leukemia_Homo sapiens_hsa052200.84935192
40TNF signaling pathway_Homo sapiens_hsa046680.83067588
41Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82955858
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82804738
43Pyruvate metabolism_Homo sapiens_hsa006200.82371206
44Other glycan degradation_Homo sapiens_hsa005110.80267340
45PPAR signaling pathway_Homo sapiens_hsa033200.79842408
46beta-Alanine metabolism_Homo sapiens_hsa004100.79395410
47Cardiac muscle contraction_Homo sapiens_hsa042600.78072324
48Notch signaling pathway_Homo sapiens_hsa043300.77499209
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76588991
50Dorso-ventral axis formation_Homo sapiens_hsa043200.76515148
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.75768230
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73857256
53Thyroid hormone synthesis_Homo sapiens_hsa049180.72909817
54Type II diabetes mellitus_Homo sapiens_hsa049300.70331418
55Hippo signaling pathway_Homo sapiens_hsa043900.68810542
56Pathways in cancer_Homo sapiens_hsa052000.68759939
57Melanoma_Homo sapiens_hsa052180.67549755
58Circadian rhythm_Homo sapiens_hsa047100.67312004
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66984704
60Insulin signaling pathway_Homo sapiens_hsa049100.66168394
61mTOR signaling pathway_Homo sapiens_hsa041500.65522476
62Phagosome_Homo sapiens_hsa041450.64234672
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63866041
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63825325
65Bladder cancer_Homo sapiens_hsa052190.63673586
66Prostate cancer_Homo sapiens_hsa052150.62938485
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61639987
68Fat digestion and absorption_Homo sapiens_hsa049750.61256139
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61047120
70Pancreatic cancer_Homo sapiens_hsa052120.60894691
71Estrogen signaling pathway_Homo sapiens_hsa049150.60879037
72Acute myeloid leukemia_Homo sapiens_hsa052210.60157614
73MicroRNAs in cancer_Homo sapiens_hsa052060.59958197
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.59624829
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.59338568
76Leishmaniasis_Homo sapiens_hsa051400.58918589
77Pertussis_Homo sapiens_hsa051330.58170129
78Legionellosis_Homo sapiens_hsa051340.57496067
79GnRH signaling pathway_Homo sapiens_hsa049120.56179584
80Oxytocin signaling pathway_Homo sapiens_hsa049210.56151716
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56116254
82Tryptophan metabolism_Homo sapiens_hsa003800.56033859
83Gastric acid secretion_Homo sapiens_hsa049710.55938688
84Fatty acid degradation_Homo sapiens_hsa000710.55791732
85Calcium signaling pathway_Homo sapiens_hsa040200.55557793
86Osteoclast differentiation_Homo sapiens_hsa043800.54893492
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54376518
88Hedgehog signaling pathway_Homo sapiens_hsa043400.53684509
89FoxO signaling pathway_Homo sapiens_hsa040680.53114635
90HIF-1 signaling pathway_Homo sapiens_hsa040660.53023617
91Glioma_Homo sapiens_hsa052140.52944200
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52686672
93Glucagon signaling pathway_Homo sapiens_hsa049220.51705618
94Renin secretion_Homo sapiens_hsa049240.51613484
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51440588
96Retinol metabolism_Homo sapiens_hsa008300.51106482
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.49685916
98Fatty acid metabolism_Homo sapiens_hsa012120.49554061
99Ovarian steroidogenesis_Homo sapiens_hsa049130.48763555
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.48687896
101cAMP signaling pathway_Homo sapiens_hsa040240.48590168
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48075264
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47813991
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.47477632
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47430405
106Renin-angiotensin system_Homo sapiens_hsa046140.46779032
107Basal cell carcinoma_Homo sapiens_hsa052170.46682973
108Staphylococcus aureus infection_Homo sapiens_hsa051500.46000048
109Propanoate metabolism_Homo sapiens_hsa006400.45657798
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44992818
111Renal cell carcinoma_Homo sapiens_hsa052110.44935171
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.44692897
113Axon guidance_Homo sapiens_hsa043600.44623694
114Melanogenesis_Homo sapiens_hsa049160.44580138
115Arginine and proline metabolism_Homo sapiens_hsa003300.43952151
116Tight junction_Homo sapiens_hsa045300.43949425
117Arachidonic acid metabolism_Homo sapiens_hsa005900.43817870
118Gap junction_Homo sapiens_hsa045400.43738111
119Wnt signaling pathway_Homo sapiens_hsa043100.43697617
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43260866
121Salmonella infection_Homo sapiens_hsa051320.43240640
122AMPK signaling pathway_Homo sapiens_hsa041520.43181310
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42666316
124MAPK signaling pathway_Homo sapiens_hsa040100.41565073
125Lysine degradation_Homo sapiens_hsa003100.37976202
126Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37845762
127Prolactin signaling pathway_Homo sapiens_hsa049170.37485298
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37417738
129Rap1 signaling pathway_Homo sapiens_hsa040150.36164101
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34086852
131Fatty acid elongation_Homo sapiens_hsa000620.33901373
132Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33271705
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32568049
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32137059

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