CICP16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1GDP-mannose metabolic process (GO:0019673)6.20433314
2cellular response to ATP (GO:0071318)5.98240455
3meiotic chromosome segregation (GO:0045132)5.64722855
4positive regulation of catecholamine secretion (GO:0033605)5.45488681
5negative regulation of cell aging (GO:0090344)5.36221982
6DNA strand renaturation (GO:0000733)5.34708558
7G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.29835897
8adenosine receptor signaling pathway (GO:0001973)5.27634309
9positive regulation of protein kinase C signaling (GO:0090037)5.16718490
10purinergic nucleotide receptor signaling pathway (GO:0035590)4.40367127
11positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.38046646
12regulation of skeletal muscle contraction (GO:0014819)4.35973590
13adenine nucleotide transport (GO:0051503)4.32609970
14purine ribonucleotide transport (GO:0015868)4.17526968
15rRNA methylation (GO:0031167)4.15672600
16mannose metabolic process (GO:0006013)4.07470791
17sensory perception of taste (GO:0050909)4.00497777
18Arp2/3 complex-mediated actin nucleation (GO:0034314)3.76606058
19histone H3-K36 demethylation (GO:0070544)3.71824751
20regulation of monocyte differentiation (GO:0045655)3.69515981
21melanin metabolic process (GO:0006582)3.61168925
22melanin biosynthetic process (GO:0042438)3.51950851
23histone phosphorylation (GO:0016572)3.50027267
24response to ATP (GO:0033198)3.45469550
25UV protection (GO:0009650)3.43816975
26gonadal mesoderm development (GO:0007506)3.42567870
273-UTR-mediated mRNA stabilization (GO:0070935)3.36386515
28G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.34186731
29positive regulation of odontogenesis (GO:0042482)3.34120907
30purinergic receptor signaling pathway (GO:0035587)3.32301542
31lens fiber cell differentiation (GO:0070306)3.25784256
32negative regulation of erythrocyte differentiation (GO:0045647)3.24411050
33negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.23245479
34urinary tract smooth muscle contraction (GO:0014848)3.20827981
35mRNA cleavage (GO:0006379)3.20651201
36germ cell migration (GO:0008354)3.17016588
37purine nucleotide transport (GO:0015865)3.16962961
38sex determination (GO:0007530)3.13115736
39rRNA modification (GO:0000154)3.12868598
40protein carboxylation (GO:0018214)3.12676219
41peptidyl-glutamic acid carboxylation (GO:0017187)3.12676219
42regulation of NFAT protein import into nucleus (GO:0051532)3.11775584
43snRNA metabolic process (GO:0016073)3.04671750
44actin nucleation (GO:0045010)3.04530439
45cellular response to virus (GO:0098586)3.03073011
46oligosaccharide catabolic process (GO:0009313)3.02479222
47mitochondrion distribution (GO:0048311)2.98860097
48mitotic chromosome condensation (GO:0007076)2.97040084
49positive regulation of gamma-delta T cell activation (GO:0046645)2.97019992
50DNA duplex unwinding (GO:0032508)2.93842239
51nucleoside transmembrane transport (GO:1901642)2.92674706
52regulation of protein kinase A signaling (GO:0010738)2.91764663
53regulation of type I interferon-mediated signaling pathway (GO:0060338)2.88149526
54positive thymic T cell selection (GO:0045059)2.87784805
55phenylpropanoid metabolic process (GO:0009698)2.86438433
56purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.84171396
57ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.84171396
58nucleoside bisphosphate biosynthetic process (GO:0033866)2.84171396
59chromatin silencing (GO:0006342)2.82330128
60peristalsis (GO:0030432)2.82287182
61stress granule assembly (GO:0034063)2.80455012
62thymic T cell selection (GO:0045061)2.80276907
63snRNA processing (GO:0016180)2.78150439
64mRNA stabilization (GO:0048255)2.78045630
65RNA stabilization (GO:0043489)2.78045630
66granulocyte differentiation (GO:0030851)2.72820409
67DNA geometric change (GO:0032392)2.72081151
68regulation of cytokine production involved in inflammatory response (GO:1900015)2.71938248
69DNA replication checkpoint (GO:0000076)2.68221930
70folic acid metabolic process (GO:0046655)2.67273102
71regulation of histone H3-K27 methylation (GO:0061085)2.66227312
72modulation by virus of host process (GO:0019054)2.61819259
73peptidyl-threonine phosphorylation (GO:0018107)2.58148991
74peptidyl-threonine modification (GO:0018210)2.55543843
75planar cell polarity pathway involved in neural tube closure (GO:0090179)2.53700842
76embryonic process involved in female pregnancy (GO:0060136)2.53269808
77regulation of ARF GTPase activity (GO:0032312)2.53008561
78positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.52669022
79trophectodermal cell differentiation (GO:0001829)2.51898636
80protein retention in ER lumen (GO:0006621)2.49264163
81regulation of gamma-delta T cell differentiation (GO:0045586)2.49071626
82histone lysine methylation (GO:0034968)2.48720482
83histone H3-K9 modification (GO:0061647)2.48583019
84regulation of DNA damage checkpoint (GO:2000001)2.48441916
85positive regulation of CREB transcription factor activity (GO:0032793)2.48408806
86negative regulation of gene expression, epigenetic (GO:0045814)2.48407975
87negative regulation of interleukin-8 production (GO:0032717)2.48319863
88secondary metabolite biosynthetic process (GO:0044550)2.48039222
89regulation of chromatin binding (GO:0035561)2.46608200
90convergent extension (GO:0060026)2.45276114
91histone H3-K9 methylation (GO:0051567)2.42161120
92retrograde transport, endosome to Golgi (GO:0042147)2.41653588
93nucleotide transmembrane transport (GO:1901679)2.40032751
94histone H4 deacetylation (GO:0070933)2.37855678
95anatomical structure regression (GO:0060033)2.36800538
96nucleoside transport (GO:0015858)2.36794879
97cell migration in hindbrain (GO:0021535)2.36647456
98nucleotide-sugar biosynthetic process (GO:0009226)2.35992183
99regulation of glycogen (starch) synthase activity (GO:2000465)2.35942901
100regulation of cell aging (GO:0090342)2.35324122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.70454628
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.03922228
3MYC_22102868_ChIP-Seq_BL_Human3.56954263
4TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.01306597
5LXR_22292898_ChIP-Seq_THP-1_Human2.93864345
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.74607537
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.65436958
8E2F7_22180533_ChIP-Seq_HELA_Human2.63021070
9MAF_26560356_Chip-Seq_TH2_Human2.60407547
10VDR_24763502_ChIP-Seq_THP-1_Human2.58897126
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.52193373
12P68_20966046_ChIP-Seq_HELA_Human2.51932503
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.47315121
14MAF_26560356_Chip-Seq_TH1_Human2.43744238
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.28968397
16KDM2B_26808549_Chip-Seq_DND41_Human2.24152576
17TCF7_22412390_ChIP-Seq_EML_Mouse2.17860678
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.11346987
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.06024792
20RACK7_27058665_Chip-Seq_MCF-7_Human2.04941693
21UTX_26944678_Chip-Seq_JUKART_Human2.04651060
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00258540
23CTCF_27219007_Chip-Seq_ERYTHROID_Human1.97423377
24BCL6_27268052_Chip-Seq_Bcells_Human1.96532375
25XRN2_22483619_ChIP-Seq_HELA_Human1.92490367
26MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.91693103
27BCOR_27268052_Chip-Seq_Bcells_Human1.90394567
28SMC4_20622854_ChIP-Seq_HELA_Human1.87438754
29CTCF_27219007_Chip-Seq_Bcells_Human1.76792409
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72524570
31E2F1_20622854_ChIP-Seq_HELA_Human1.70157596
32SA1_27219007_Chip-Seq_ERYTHROID_Human1.69389190
33PHF8_20622854_ChIP-Seq_HELA_Human1.67853743
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67536304
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.62012520
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.61664329
37CREB1_26743006_Chip-Seq_LNCaP_Human1.56109955
38CTCF_21964334_Chip-Seq_Bcells_Human1.54019820
39SCL_19346495_ChIP-Seq_HPC-7_Human1.53408502
40NCOR1_26117541_ChIP-Seq_K562_Human1.53225056
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.52453209
42KDM2B_26808549_Chip-Seq_K562_Human1.46616838
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46046469
44RARB_24833708_ChIP-Seq_LIVER_Mouse1.45004921
45EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42927637
46CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39432967
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.39367555
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.37875199
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37652219
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36922778
51CTCF_21964334_ChIP-Seq_BJAB-B_Human1.35191988
52RARA_24833708_ChIP-Seq_LIVER_Mouse1.30437775
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28694932
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27830513
55TP53_22127205_ChIP-Seq_IMR90_Human1.26911751
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24585045
57ETS1_21867929_ChIP-Seq_TH2_Mouse1.23871571
58PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22939780
59CIITA_25753668_ChIP-Seq_RAJI_Human1.21918320
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21397338
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21275286
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20803254
63SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20707565
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.19778374
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17992099
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.16722255
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.16018884
68FOXP1_21924763_ChIP-Seq_HESCs_Human1.15793911
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15778820
70SA1_27219007_Chip-Seq_Bcells_Human1.15770238
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.14878556
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.14072678
73YY1_22570637_ChIP-Seq_MALME-3M_Human1.13321422
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12574428
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12535330
76PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12283432
77RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10277069
78CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09865398
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08900584
80CTCF_20526341_ChIP-Seq_ESCs_Human1.07949047
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07027171
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06348498
83TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05733215
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04932559
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04750694
86ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03574891
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02099113
88TP63_22573176_ChIP-Seq_HFKS_Human1.01856474
89P300_27268052_Chip-Seq_Bcells_Human1.01855072
90FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00207358
91ATF3_27146783_Chip-Seq_COLON_Human0.99997063
92CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99988031
93GATA1_19941826_ChIP-Seq_K562_Human0.98355252
94EGR1_19374776_ChIP-ChIP_THP-1_Human0.97744049
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97646044
96MYB_26560356_Chip-Seq_TH1_Human0.97295197
97JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97255334
98DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97033132
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.96766379
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96668091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation5.78506249
2MP0005174_abnormal_tail_pigmentation5.13953644
3MP0003136_yellow_coat_color5.10322509
4MP0001986_abnormal_taste_sensitivity4.48341063
5MP0009278_abnormal_bone_marrow4.22736640
6MP0005423_abnormal_somatic_nervous3.91823340
7MP0005409_darkened_coat_color3.17106726
8MP0004381_abnormal_hair_follicle2.72702830
9MP0000015_abnormal_ear_pigmentation2.66890984
10MP0005076_abnormal_cell_differentiation2.43877140
11MP0003705_abnormal_hypodermis_morpholog2.32430742
12MP0003111_abnormal_nucleus_morphology2.17965907
13MP0004808_abnormal_hematopoietic_stem2.08761582
14MP0003091_abnormal_cell_migration1.99582151
15MP0003693_abnormal_embryo_hatching1.91852817
16MP0005083_abnormal_biliary_tract1.90202583
17MP0003329_amyloid_beta_deposits1.87120075
18MP0001188_hyperpigmentation1.82316527
19MP0005397_hematopoietic_system_phenotyp1.76266675
20MP0001545_abnormal_hematopoietic_system1.76266675
21MP0003763_abnormal_thymus_physiology1.70596475
22MP0001873_stomach_inflammation1.61501093
23MP0004858_abnormal_nervous_system1.61394257
24MP0001502_abnormal_circadian_rhythm1.60329507
25MP0000751_myopathy1.57293248
26MP0001661_extended_life_span1.56622304
27MP0003453_abnormal_keratinocyte_physiol1.50773530
28MP0005058_abnormal_lysosome_morphology1.43453635
29MP0005451_abnormal_body_composition1.40236221
30MP0010094_abnormal_chromosome_stability1.34723573
31MP0002638_abnormal_pupillary_reflex1.34581742
32MP0003077_abnormal_cell_cycle1.32482269
33MP0001968_abnormal_touch/_nociception1.32255143
34MP0004130_abnormal_muscle_cell1.25007536
35MP0003303_peritoneal_inflammation1.23799297
36MP0002009_preneoplasia1.22137880
37MP0000538_abnormal_urinary_bladder1.19991714
38MP0004947_skin_inflammation1.14722796
39MP0000703_abnormal_thymus_morphology1.13992322
40MP0003632_abnormal_nervous_system1.12601962
41MP0002398_abnormal_bone_marrow1.09744398
42MP0001756_abnormal_urination1.07282089
43MP0002405_respiratory_system_inflammati1.06806458
44MP0000003_abnormal_adipose_tissue1.04655757
45MP0009333_abnormal_splenocyte_physiolog1.02956475
46MP0004957_abnormal_blastocyst_morpholog1.02670665
47MP0000685_abnormal_immune_system1.00591529
48MP0002249_abnormal_larynx_morphology0.99686254
49MP0000604_amyloidosis0.95427214
50MP0002722_abnormal_immune_system0.94582743
51MP0002396_abnormal_hematopoietic_system0.93177223
52MP0003172_abnormal_lysosome_physiology0.92794611
53MP0000689_abnormal_spleen_morphology0.90052025
54MP0002933_joint_inflammation0.86477919
55MP0008057_abnormal_DNA_replication0.83902315
56MP0001958_emphysema0.81049347
57MP0002429_abnormal_blood_cell0.80834476
58MP0005220_abnormal_exocrine_pancreas0.80512999
59MP0005621_abnormal_cell_physiology0.79304093
60MP0000371_diluted_coat_color0.79147965
61MP0000716_abnormal_immune_system0.78909264
62MP0002019_abnormal_tumor_incidence0.78380764
63MP0004782_abnormal_surfactant_physiolog0.76307507
64MP0005410_abnormal_fertilization0.74694404
65MP0004233_abnormal_muscle_weight0.74490277
66MP0000750_abnormal_muscle_regeneration0.74273229
67MP0005584_abnormal_enzyme/coenzyme_acti0.73638549
68MP0001849_ear_inflammation0.73060681
69MP0002075_abnormal_coat/hair_pigmentati0.72771945
70MP0002452_abnormal_antigen_presenting0.70773737
71MP0001800_abnormal_humoral_immune0.70306987
72MP0009931_abnormal_skin_appearance0.69090348
73MP0008260_abnormal_autophagy0.67363795
74MP0002420_abnormal_adaptive_immunity0.66664384
75MP0000747_muscle_weakness0.66384993
76MP0003984_embryonic_growth_retardation0.65830987
77MP0001765_abnormal_ion_homeostasis0.65766739
78MP0001919_abnormal_reproductive_system0.65689487
79MP0001819_abnormal_immune_cell0.65147948
80MP0002877_abnormal_melanocyte_morpholog0.63449101
81MP0002723_abnormal_immune_serum0.63233266
82MP0002086_abnormal_extraembryonic_tissu0.62284643
83MP0002080_prenatal_lethality0.61802637
84MP0009840_abnormal_foam_cell0.61445354
85MP0001672_abnormal_embryogenesis/_devel0.60447745
86MP0005380_embryogenesis_phenotype0.60447745
87MP0002088_abnormal_embryonic_growth/wei0.60426330
88MP0000013_abnormal_adipose_tissue0.57872536
89MP0000490_abnormal_crypts_of0.57770186
90MP0005025_abnormal_response_to0.57080465
91MP0003959_abnormal_lean_body0.56845100
92MP0003436_decreased_susceptibility_to0.56328606
93MP0001835_abnormal_antigen_presentation0.55869000
94MP0004197_abnormal_fetal_growth/weight/0.55570570
95MP0008961_abnormal_basal_metabolism0.55232680
96MP0001348_abnormal_lacrimal_gland0.54184877
97MP0003448_altered_tumor_morphology0.54090431
98MP0001790_abnormal_immune_system0.53556022
99MP0005387_immune_system_phenotype0.53556022
100MP0000350_abnormal_cell_proliferation0.53485106

Predicted human phenotypes

RankGene SetZ-score
1Annular pancreas (HP:0001734)5.36201493
2Ulnar bowing (HP:0003031)5.18329567
3Rib fusion (HP:0000902)4.89623004
4Intestinal fistula (HP:0100819)4.76231767
5Testicular atrophy (HP:0000029)4.56554568
6Facial hemangioma (HP:0000329)4.40597130
7Turricephaly (HP:0000262)4.36285093
8Rectal fistula (HP:0100590)4.34638849
9Rectovaginal fistula (HP:0000143)4.34638849
10Congenital stationary night blindness (HP:0007642)4.29034057
11Thin bony cortex (HP:0002753)4.24326616
12Poikiloderma (HP:0001029)4.23274229
13Vaginal fistula (HP:0004320)4.20806525
14Anteriorly placed anus (HP:0001545)3.66477094
15Attenuation of retinal blood vessels (HP:0007843)3.53000738
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.26915423
17Hemorrhage of the eye (HP:0011885)3.17506677
18Squamous cell carcinoma (HP:0002860)3.14906149
19Abnormality of the intrinsic pathway (HP:0010989)3.08663758
20Popliteal pterygium (HP:0009756)3.06011679
21Dyschromatopsia (HP:0007641)3.04495563
22Coronal craniosynostosis (HP:0004440)2.97800018
23Facial diplegia (HP:0001349)2.97609999
24Patellar aplasia (HP:0006443)2.92109806
25Akinesia (HP:0002304)2.88059559
26Capillary hemangiomas (HP:0005306)2.80881115
27Abnormality of the fingertips (HP:0001211)2.73326204
28Aplasia/Hypoplasia of the patella (HP:0006498)2.66729367
29Bony spicule pigmentary retinopathy (HP:0007737)2.64284593
30Aplasia of the musculature (HP:0100854)2.63039876
31Delayed epiphyseal ossification (HP:0002663)2.62541108
32Birth length less than 3rd percentile (HP:0003561)2.61773393
33Widely patent fontanelles and sutures (HP:0004492)2.59934226
34Premature graying of hair (HP:0002216)2.56922727
35Absent thumb (HP:0009777)2.55652119
36Breast hypoplasia (HP:0003187)2.55224154
37Bowing of the arm (HP:0006488)2.50978420
38Bowed forearm bones (HP:0003956)2.50978420
39Absent radius (HP:0003974)2.50785666
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49334236
41Short chin (HP:0000331)2.49314271
42Abnormality of the costochondral junction (HP:0000919)2.45155780
43Joint stiffness (HP:0001387)2.44364766
44Thin ribs (HP:0000883)2.38266662
45Short humerus (HP:0005792)2.34145214
46Increased number of teeth (HP:0011069)2.29241471
47Basal cell carcinoma (HP:0002671)2.28066384
48Aplasia involving forearm bones (HP:0009822)2.27728215
49Absent forearm bone (HP:0003953)2.27728215
50Mesangial abnormality (HP:0001966)2.24866207
51Broad face (HP:0000283)2.20999095
52Global brain atrophy (HP:0002283)2.20375562
53Neonatal respiratory distress (HP:0002643)2.19416405
54Impaired smooth pursuit (HP:0007772)2.14557048
55Recurrent cutaneous fungal infections (HP:0011370)2.14009206
56Chronic mucocutaneous candidiasis (HP:0002728)2.14009206
57Prominent nose (HP:0000448)2.13381444
58Male infertility (HP:0003251)2.12666308
59Flat occiput (HP:0005469)2.08172132
60Short thumb (HP:0009778)2.07048731
61Aplasia/hypoplasia of the humerus (HP:0006507)2.06187278
62Spina bifida occulta (HP:0003298)2.03110371
63Colitis (HP:0002583)1.99858494
64Fetal akinesia sequence (HP:0001989)1.99743537
65Abnormality of pyrimidine metabolism (HP:0004353)1.99064343
66Duplicated collecting system (HP:0000081)1.98470211
67Vertebral clefting (HP:0008428)1.97611117
68Chromsome breakage (HP:0040012)1.93397155
69Genu recurvatum (HP:0002816)1.92778245
70Abnormality of saccadic eye movements (HP:0000570)1.90716184
71Ectopic kidney (HP:0000086)1.90609258
72Arterial tortuosity (HP:0005116)1.90147716
73Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.87458223
74Dislocated radial head (HP:0003083)1.87325688
75Joint hemorrhage (HP:0005261)1.87099469
76Enlarged epiphyses (HP:0010580)1.86780487
77Pustule (HP:0200039)1.85306826
78Atrioventricular block (HP:0001678)1.85142928
79Hyperacusis (HP:0010780)1.84277945
80Abnormality of small intestinal villus morphology (HP:0011472)1.83129135
81Villous atrophy (HP:0011473)1.83129135
82Optic nerve coloboma (HP:0000588)1.79050634
83Metaphyseal cupping (HP:0003021)1.78678214
84Broad distal phalanx of finger (HP:0009836)1.78404485
85Choanal stenosis (HP:0000452)1.77789395
86Abnormality of the columella (HP:0009929)1.76124990
87Wide cranial sutures (HP:0010537)1.75803394
88Abnormality of the renal collecting system (HP:0004742)1.75573794
89Abnormality of the radial head (HP:0003995)1.74037489
90Pendular nystagmus (HP:0012043)1.73622168
91Hypotelorism (HP:0000601)1.71542474
92Urinary glycosaminoglycan excretion (HP:0003541)1.69816139
93Mucopolysacchariduria (HP:0008155)1.69816139
94Chorioretinal atrophy (HP:0000533)1.69631667
95Cervical subluxation (HP:0003308)1.69416746
96Abnormality of DNA repair (HP:0003254)1.68600764
97Truncal obesity (HP:0001956)1.66802791
98Increased neuronal autofluorescent lipopigment (HP:0002074)1.66599308
99Dysmetric saccades (HP:0000641)1.65988477
100Easy fatigability (HP:0003388)1.65324928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.12435878
2CDK123.75009673
3TRIB33.45311606
4ICK2.91900958
5ERN12.80557869
6MAP3K102.73749999
7TESK22.65213294
8BLK2.60561307
9EEF2K2.51190812
10MAP2K32.38846789
11WNK42.23866925
12SMG12.08845991
13PRPF4B2.04704890
14GRK61.96402739
15SIK11.88987501
16SIK21.81730259
17ZAP701.77793789
18MAP4K11.76177331
19CDK41.67001445
20TLK11.48867760
21NEK21.46165941
22BRD41.41144471
23MTOR1.35549311
24WNK11.24663530
25MAPK111.19528343
26RPS6KL11.16319746
27RPS6KC11.16319746
28GRK11.14216788
29KSR21.13861498
30IRAK21.13813913
31PRKD21.12450936
32CDK61.11238049
33PKN21.08426182
34RPS6KA61.04671805
35RAF11.02993889
36TTN1.01132633
37RPS6KA20.95083796
38PIM20.92832493
39CAMK1D0.89958068
40MAPK120.89765186
41FGFR30.88672266
42MAP3K10.87706146
43PDPK10.86237128
44MARK20.80853021
45MAP3K130.80604089
46MAP3K70.77704274
47TAOK20.77611373
48TBK10.77442162
49MAP3K140.76812379
50PRKD30.74940446
51LATS10.74116327
52ZAK0.73586201
53DYRK1B0.73426659
54STK380.73266075
55IRAK30.72152161
56MELK0.71566694
57BTK0.68343828
58TGFBR10.66049228
59FGFR40.63710414
60MUSK0.63670768
61CDC42BPA0.63614134
62MAPK70.61991292
63ATR0.60872618
64ADRBK20.59863350
65CSK0.57766054
66TGFBR20.55601058
67TAOK10.54238710
68SYK0.52746216
69BMX0.51624604
70IKBKE0.51475402
71DDR20.51449918
72HIPK20.50917461
73CDK30.49246458
74MAP3K30.48455912
75MAP3K80.48054094
76MAP3K110.48014559
77RET0.46320459
78TNK20.46290462
79RPS6KA10.45395984
80PDGFRA0.44530253
81AURKA0.44232182
82TYRO30.43844828
83CDK20.43685660
84CHEK20.41386935
85CDK70.40912126
86JAK30.40008251
87SRPK10.39268341
88DYRK30.39011320
89PIM10.38661712
90MAP2K20.37914765
91PRKD10.37629923
92CHEK10.37262105
93IRAK40.37107618
94MAPK80.36323017
95HCK0.36266894
96AKT20.36079434
97MAPK30.34847429
98RPS6KB20.34844742
99PDGFRB0.33290471
100CDK80.32971987

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006045.41134902
2Sulfur relay system_Homo sapiens_hsa041224.06319635
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.60780184
4Other glycan degradation_Homo sapiens_hsa005112.77665884
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.61475930
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.29702756
7Fructose and mannose metabolism_Homo sapiens_hsa000512.08682741
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89068563
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.86221526
10Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.78665553
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70759174
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62365146
13Lysine degradation_Homo sapiens_hsa003101.54301204
14mTOR signaling pathway_Homo sapiens_hsa041501.31732175
15Bladder cancer_Homo sapiens_hsa052191.29163983
16Acute myeloid leukemia_Homo sapiens_hsa052211.27902872
17Notch signaling pathway_Homo sapiens_hsa043301.27266809
18Fanconi anemia pathway_Homo sapiens_hsa034601.26266536
19Hedgehog signaling pathway_Homo sapiens_hsa043401.26107501
20Chronic myeloid leukemia_Homo sapiens_hsa052201.25003424
21Non-small cell lung cancer_Homo sapiens_hsa052231.24669178
22Primary immunodeficiency_Homo sapiens_hsa053401.21258923
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.15926911
24B cell receptor signaling pathway_Homo sapiens_hsa046621.14840224
25Sphingolipid metabolism_Homo sapiens_hsa006001.14691000
26Taste transduction_Homo sapiens_hsa047421.13389076
27Inositol phosphate metabolism_Homo sapiens_hsa005621.13344147
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02043491
29T cell receptor signaling pathway_Homo sapiens_hsa046600.98150048
30Thyroid cancer_Homo sapiens_hsa052160.96702516
31Cell cycle_Homo sapiens_hsa041100.95913095
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95836595
33Hepatitis B_Homo sapiens_hsa051610.94791869
34HTLV-I infection_Homo sapiens_hsa051660.92524422
35Osteoclast differentiation_Homo sapiens_hsa043800.92177934
36Endometrial cancer_Homo sapiens_hsa052130.91500829
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89737388
38Neurotrophin signaling pathway_Homo sapiens_hsa047220.89262776
39VEGF signaling pathway_Homo sapiens_hsa043700.88603523
40Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88255628
41Base excision repair_Homo sapiens_hsa034100.87146940
42Pancreatic cancer_Homo sapiens_hsa052120.86601495
43Apoptosis_Homo sapiens_hsa042100.84715659
44Hepatitis C_Homo sapiens_hsa051600.80669017
45Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80469737
46mRNA surveillance pathway_Homo sapiens_hsa030150.79241356
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78054086
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77672834
49MicroRNAs in cancer_Homo sapiens_hsa052060.75475047
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73149488
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72642980
52TNF signaling pathway_Homo sapiens_hsa046680.72525590
53Small cell lung cancer_Homo sapiens_hsa052220.71282971
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70654527
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69566125
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.67944352
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64821259
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63525603
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.62845449
60Colorectal cancer_Homo sapiens_hsa052100.61635740
61Melanogenesis_Homo sapiens_hsa049160.61618056
62Basal cell carcinoma_Homo sapiens_hsa052170.61475999
63Viral carcinogenesis_Homo sapiens_hsa052030.60952462
64Gap junction_Homo sapiens_hsa045400.60895176
65Herpes simplex infection_Homo sapiens_hsa051680.60865367
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.60349676
67Prostate cancer_Homo sapiens_hsa052150.60282581
68Influenza A_Homo sapiens_hsa051640.59615279
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58365850
70FoxO signaling pathway_Homo sapiens_hsa040680.57070740
71DNA replication_Homo sapiens_hsa030300.55913112
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55756843
73Circadian rhythm_Homo sapiens_hsa047100.55424405
74Lysosome_Homo sapiens_hsa041420.54089321
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54015861
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.53789909
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53440158
78Hippo signaling pathway_Homo sapiens_hsa043900.52245118
79Measles_Homo sapiens_hsa051620.51596583
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.51395595
81Insulin resistance_Homo sapiens_hsa049310.47664497
82Hematopoietic cell lineage_Homo sapiens_hsa046400.47249426
83Vitamin digestion and absorption_Homo sapiens_hsa049770.45172668
84Calcium signaling pathway_Homo sapiens_hsa040200.45029678
85MAPK signaling pathway_Homo sapiens_hsa040100.43278729
86Chemokine signaling pathway_Homo sapiens_hsa040620.43162889
87GnRH signaling pathway_Homo sapiens_hsa049120.42752315
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42185352
89N-Glycan biosynthesis_Homo sapiens_hsa005100.42128206
90Platelet activation_Homo sapiens_hsa046110.41956846
91Insulin signaling pathway_Homo sapiens_hsa049100.41595620
92Endocytosis_Homo sapiens_hsa041440.41326612
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40534052
94Toxoplasmosis_Homo sapiens_hsa051450.39775125
95Alcoholism_Homo sapiens_hsa050340.39726475
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.39236461
97Prion diseases_Homo sapiens_hsa050200.37130392
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37109193
99Estrogen signaling pathway_Homo sapiens_hsa049150.36992757
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36543013

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