CIAPIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.81892325
2proteasome assembly (GO:0043248)4.74032825
3cullin deneddylation (GO:0010388)4.58540462
4DNA deamination (GO:0045006)4.51658155
5DNA strand elongation involved in DNA replication (GO:0006271)4.47515121
6nucleobase biosynthetic process (GO:0046112)4.34683326
7protein deneddylation (GO:0000338)4.24664348
8DNA strand elongation (GO:0022616)4.23563902
9telomere maintenance via semi-conservative replication (GO:0032201)4.23563187
10purine nucleobase biosynthetic process (GO:0009113)4.21057865
11DNA replication checkpoint (GO:0000076)4.16687353
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.00635780
13establishment of viral latency (GO:0019043)4.00017852
14DNA replication initiation (GO:0006270)3.99555270
15spliceosomal snRNP assembly (GO:0000387)3.98134423
16anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.92779758
17chaperone-mediated protein transport (GO:0072321)3.91982256
18DNA replication-dependent nucleosome organization (GO:0034723)3.91677406
19DNA replication-dependent nucleosome assembly (GO:0006335)3.91677406
20ribosome assembly (GO:0042255)3.84983604
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.82946461
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82371183
23folic acid-containing compound biosynthetic process (GO:0009396)3.79477261
24formation of translation preinitiation complex (GO:0001731)3.70783030
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.70315718
26negative regulation of ligase activity (GO:0051352)3.70315718
27telomere maintenance via recombination (GO:0000722)3.68654541
28maturation of SSU-rRNA (GO:0030490)3.64976218
29DNA damage response, detection of DNA damage (GO:0042769)3.64726413
30nucleotide-excision repair, DNA gap filling (GO:0006297)3.63707336
31protein localization to kinetochore (GO:0034501)3.63284731
32IMP biosynthetic process (GO:0006188)3.63013423
33histone arginine methylation (GO:0034969)3.62358699
34mitotic metaphase plate congression (GO:0007080)3.59993803
35peptidyl-arginine omega-N-methylation (GO:0035247)3.59322890
36ribosome biogenesis (GO:0042254)3.58127706
37energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58024360
38ATP synthesis coupled proton transport (GO:0015986)3.58024360
39viral mRNA export from host cell nucleus (GO:0046784)3.53337180
40positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.43478513
41rRNA modification (GO:0000154)3.41748314
42mitotic nuclear envelope disassembly (GO:0007077)3.41583600
43DNA ligation (GO:0006266)3.39545579
44chromatin remodeling at centromere (GO:0031055)3.38374169
45negative regulation of protein acetylation (GO:1901984)3.38090599
46mitotic recombination (GO:0006312)3.38062426
47tRNA aminoacylation for protein translation (GO:0006418)3.37305484
48negative regulation of peptidyl-lysine acetylation (GO:2000757)3.36540771
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.35999734
50CENP-A containing nucleosome assembly (GO:0034080)3.35316023
51telomere maintenance via telomere lengthening (GO:0010833)3.34173735
52regulation of cellular amino acid metabolic process (GO:0006521)3.34093987
53deoxyribonucleotide biosynthetic process (GO:0009263)3.33136228
54DNA catabolic process, exonucleolytic (GO:0000738)3.33047277
55amino acid activation (GO:0043038)3.31193489
56tRNA aminoacylation (GO:0043039)3.31193489
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.30001718
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.30001718
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.30001718
60mitotic sister chromatid segregation (GO:0000070)3.29679909
61intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29661808
62signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29661808
63regulation of mitochondrial translation (GO:0070129)3.28871085
64signal transduction involved in DNA damage checkpoint (GO:0072422)3.28852733
65signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28852733
66ribonucleoprotein complex biogenesis (GO:0022613)3.28845331
67rRNA methylation (GO:0031167)3.28354141
68maturation of 5.8S rRNA (GO:0000460)3.27995448
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27055458
70DNA double-strand break processing (GO:0000729)3.26462912
71negative regulation of histone acetylation (GO:0035067)3.26185301
72signal transduction involved in cell cycle checkpoint (GO:0072395)3.25073832
73positive regulation of ligase activity (GO:0051351)3.24568317
74IMP metabolic process (GO:0046040)3.24170609
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.23935980
76termination of RNA polymerase III transcription (GO:0006386)3.23935980
77ribosomal large subunit biogenesis (GO:0042273)3.20689452
78cell cycle G1/S phase transition (GO:0044843)3.18359601
79G1/S transition of mitotic cell cycle (GO:0000082)3.18359601
80spliceosomal complex assembly (GO:0000245)3.17727873
81regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17153813
82mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.16538756
83negative regulation of chromosome segregation (GO:0051985)3.16399907
84transcription-coupled nucleotide-excision repair (GO:0006283)3.16287232
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15998725
86membrane disassembly (GO:0030397)3.15318612
87nuclear envelope disassembly (GO:0051081)3.15318612
88regulation of ubiquitin-protein transferase activity (GO:0051438)3.15109216
89rRNA processing (GO:0006364)3.14715599
90negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14488478
91negative regulation of sister chromatid segregation (GO:0033046)3.14488478
92negative regulation of mitotic sister chromatid separation (GO:2000816)3.14488478
93negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14488478
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09154386
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.07377590
96L-serine metabolic process (GO:0006563)3.04390284
97oxidative phosphorylation (GO:0006119)3.02213286
98DNA unwinding involved in DNA replication (GO:0006268)3.01959888
99mitotic spindle assembly checkpoint (GO:0007094)3.01661021
100establishment of protein localization to mitochondrion (GO:0072655)3.01562860
101pseudouridine synthesis (GO:0001522)3.01168992
102rRNA metabolic process (GO:0016072)3.01037305
103regulation of ligase activity (GO:0051340)3.00391563
104histone exchange (GO:0043486)2.99391508
105mitotic spindle checkpoint (GO:0071174)2.99016746
106regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98604602
107protein insertion into membrane (GO:0051205)2.98205720
108spindle checkpoint (GO:0031577)2.98168908
109double-strand break repair via nonhomologous end joining (GO:0006303)2.97709721
110non-recombinational repair (GO:0000726)2.97709721
111deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97626049
112sister chromatid segregation (GO:0000819)2.97294052
113metaphase plate congression (GO:0051310)2.97093519
114spindle assembly checkpoint (GO:0071173)2.96793550
115protein localization to mitochondrion (GO:0070585)2.96011133
116establishment of protein localization to mitochondrial membrane (GO:0090151)2.95607769
117negative regulation of protein ubiquitination (GO:0031397)2.95426731
118protein localization to chromosome, centromeric region (GO:0071459)2.94958523
119protein complex localization (GO:0031503)2.93466949
120mitochondrial RNA metabolic process (GO:0000959)2.93208344
121regulation of mitotic spindle checkpoint (GO:1903504)2.92735978
122regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92735978
123protein targeting to mitochondrion (GO:0006626)2.92570471
124respiratory chain complex IV assembly (GO:0008535)2.91681599
125DNA replication-independent nucleosome assembly (GO:0006336)2.90966603
126DNA replication-independent nucleosome organization (GO:0034724)2.90966603
127protein neddylation (GO:0045116)2.89507499
128mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87972568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.79720624
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.59979576
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.85470559
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65720234
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38414985
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37143097
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.28363935
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.25061629
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23414356
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.17026917
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.16329646
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.15906685
13GABP_17652178_ChIP-ChIP_JURKAT_Human3.15301648
14MYC_19030024_ChIP-ChIP_MESCs_Mouse3.03153280
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99917651
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.96818493
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93250616
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81680230
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75572421
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69935849
21* XRN2_22483619_ChIP-Seq_HELA_Human2.63495353
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.49518674
23DCP1A_22483619_ChIP-Seq_HELA_Human2.39115080
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.38578254
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36236493
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.36044241
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27602991
28YY1_21170310_ChIP-Seq_MESCs_Mouse2.10125653
29VDR_23849224_ChIP-Seq_CD4+_Human2.09499930
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06769088
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.98785462
32TTF2_22483619_ChIP-Seq_HELA_Human1.96293304
33GABP_19822575_ChIP-Seq_HepG2_Human1.96059830
34* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92285773
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.87162150
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86579312
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81285874
38FOXP3_21729870_ChIP-Seq_TREG_Human1.79799985
39AR_21909140_ChIP-Seq_LNCAP_Human1.78202067
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76657133
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.75619572
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.74745668
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.63300663
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60056144
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59527189
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58637064
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55335706
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53316043
49KDM5A_27292631_Chip-Seq_BREAST_Human1.52936571
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51740797
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.50884330
52* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46599231
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.46171745
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44555596
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44493231
56* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43380654
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35588356
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33446447
59ELK1_19687146_ChIP-ChIP_HELA_Human1.32429184
60NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31409348
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31296851
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31296851
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31296851
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.31073812
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29731799
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27108264
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26601431
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19155190
69SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17891449
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15802881
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13956069
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12520411
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.12388661
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11673293
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09339680
76NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08378928
77OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06944247
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06597325
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05986095
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05625931
81MYC_18940864_ChIP-ChIP_HL60_Human1.05591902
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04592521
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04457589
84* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03595858
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02767059
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02404025
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.02263501
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01401189
89PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98822780
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98747020
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97329882
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96364414
93CIITA_25753668_ChIP-Seq_RAJI_Human0.96022022
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94381103
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.94241515
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94155665
97ZNF274_21170338_ChIP-Seq_K562_Hela0.92990605
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.91791253
99SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91345475
100SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90788582
101* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89999550
102POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89419322
103CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89316248
104TP63_19390658_ChIP-ChIP_HaCaT_Human0.88749212
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87936018
106IRF1_19129219_ChIP-ChIP_H3396_Human0.87678997
107YY1_22570637_ChIP-Seq_MALME-3M_Human0.87555355
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.87423760
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87364199
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85769772
111SOX17_20123909_ChIP-Seq_XEN_Mouse0.85159497
112SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84830313
113POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84589717
114CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83960445
115NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.83716191
116EWS_26573619_Chip-Seq_HEK293_Human0.81715503
117TFEB_21752829_ChIP-Seq_HELA_Human0.78021761
118CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76949498
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.75115147
120* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71930383
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71162908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.05249756
2MP0004957_abnormal_blastocyst_morpholog4.67091032
3MP0010094_abnormal_chromosome_stability4.02615403
4MP0003111_abnormal_nucleus_morphology4.00723476
5MP0003077_abnormal_cell_cycle3.46958813
6MP0008932_abnormal_embryonic_tissue3.35864591
7MP0008007_abnormal_cellular_replicative3.09046306
8MP0008058_abnormal_DNA_repair2.96744252
9MP0008057_abnormal_DNA_replication2.84376681
10MP0003806_abnormal_nucleotide_metabolis2.77492635
11MP0003718_maternal_effect2.61702932
12MP0010030_abnormal_orbit_morphology2.54980526
13MP0004270_analgesia2.33692841
14MP0008877_abnormal_DNA_methylation2.22798445
15MP0004133_heterotaxia2.22344710
16MP0003786_premature_aging2.18690006
17MP0001730_embryonic_growth_arrest2.17839409
18MP0003646_muscle_fatigue1.95368504
19MP0000350_abnormal_cell_proliferation1.95136457
20MP0009379_abnormal_foot_pigmentation1.90811366
21MP0003123_paternal_imprinting1.89100997
22MP0009697_abnormal_copulation1.76358141
23MP0003890_abnormal_embryonic-extraembry1.69945043
24MP0002210_abnormal_sex_determination1.64237239
25MP0005380_embryogenesis_phenotype1.63350786
26MP0001672_abnormal_embryogenesis/_devel1.63350786
27MP0002653_abnormal_ependyma_morphology1.60488521
28* MP0001697_abnormal_embryo_size1.59158392
29MP0006035_abnormal_mitochondrial_morpho1.57689364
30MP0003315_abnormal_perineum_morphology1.57355761
31MP0002085_abnormal_embryonic_tissue1.57192187
32* MP0002080_prenatal_lethality1.47030936
33MP0003984_embryonic_growth_retardation1.44988932
34MP0001145_abnormal_male_reproductive1.43018571
35MP0002088_abnormal_embryonic_growth/wei1.42847936
36MP0001929_abnormal_gametogenesis1.38229331
37MP0000372_irregular_coat_pigmentation1.38021338
38MP0002084_abnormal_developmental_patter1.35761075
39MP0002102_abnormal_ear_morphology1.33389926
40MP0002751_abnormal_autonomic_nervous1.29369583
41MP0002160_abnormal_reproductive_system1.27691974
42MP0006036_abnormal_mitochondrial_physio1.24200891
43MP0006276_abnormal_autonomic_nervous1.23636315
44MP0004084_abnormal_cardiac_muscle1.22714514
45MP0000653_abnormal_sex_gland1.21621407
46MP0002233_abnormal_nose_morphology1.20388392
47MP0009672_abnormal_birth_weight1.20347068
48MP0003221_abnormal_cardiomyocyte_apopto1.19240136
49MP0003698_abnormal_male_reproductive1.17862523
50MP0006292_abnormal_olfactory_placode1.15787924
51MP0002127_abnormal_cardiovascular_syste1.15274051
52MP0003119_abnormal_digestive_system1.13270659
53MP0003121_genomic_imprinting1.12748424
54MP0000537_abnormal_urethra_morphology1.11517167
55MP0000358_abnormal_cell_content/1.11097087
56MP0000313_abnormal_cell_death1.11006566
57MP0001529_abnormal_vocalization1.10853784
58MP0008260_abnormal_autophagy1.10425391
59MP0001984_abnormal_olfaction1.09988802
60MP0003567_abnormal_fetal_cardiomyocyte1.07503621
61MP0008995_early_reproductive_senescence1.07363559
62MP0005410_abnormal_fertilization1.04924897
63MP0002086_abnormal_extraembryonic_tissu1.04029937
64MP0003880_abnormal_central_pattern1.03996791
65MP0002822_catalepsy1.03086606
66MP0002234_abnormal_pharynx_morphology1.02690253
67MP0001286_abnormal_eye_development1.00707592
68MP0001346_abnormal_lacrimal_gland0.98251055
69MP0001764_abnormal_homeostasis0.97764535
70MP0001293_anophthalmia0.97760154
71MP0002697_abnormal_eye_size0.95283566
72MP0003136_yellow_coat_color0.94868163
73MP0009053_abnormal_anal_canal0.94304558
74MP0003186_abnormal_redox_activity0.94297208
75MP0003861_abnormal_nervous_system0.92719814
76MP0002269_muscular_atrophy0.92461582
77MP0005266_abnormal_metabolism0.91356672
78MP0000647_abnormal_sebaceous_gland0.90560506
79MP0000579_abnormal_nail_morphology0.90113161
80MP0002161_abnormal_fertility/fecundity0.86428587
81MP0003937_abnormal_limbs/digits/tail_de0.86335532
82MP0002638_abnormal_pupillary_reflex0.85293035
83MP0003122_maternal_imprinting0.84715180
84MP0004147_increased_porphyrin_level0.84342155
85MP0010352_gastrointestinal_tract_polyps0.82813227
86MP0004197_abnormal_fetal_growth/weight/0.82658449
87MP0001905_abnormal_dopamine_level0.81665713
88MP0002111_abnormal_tail_morphology0.81147392
89MP0005623_abnormal_meninges_morphology0.79381090
90MP0006072_abnormal_retinal_apoptosis0.79245467
91MP0002735_abnormal_chemical_nociception0.78854199
92MP0008789_abnormal_olfactory_epithelium0.78761637
93MP0002090_abnormal_vision0.78704970
94MP0001119_abnormal_female_reproductive0.77330206
95MP0003137_abnormal_impulse_conducting0.76884324
96MP0010307_abnormal_tumor_latency0.76653486
97MP0005389_reproductive_system_phenotype0.76251928
98MP0000049_abnormal_middle_ear0.76040941
99MP0002938_white_spotting0.75886775
100MP0001727_abnormal_embryo_implantation0.73277119
101MP0002019_abnormal_tumor_incidence0.72793324
102MP0000750_abnormal_muscle_regeneration0.72782822
103MP0003941_abnormal_skin_development0.72362228
104MP0002736_abnormal_nociception_after0.71642954
105MP0005391_vision/eye_phenotype0.71499025
106MP0005394_taste/olfaction_phenotype0.70573620
107MP0005499_abnormal_olfactory_system0.70573620
108MP0004233_abnormal_muscle_weight0.70541431
109MP0009703_decreased_birth_body0.70524721
110MP0003938_abnormal_ear_development0.70206750
111MP0005395_other_phenotype0.69801667
112MP0003385_abnormal_body_wall0.69661250
113MP0002282_abnormal_trachea_morphology0.69050606
114MP0002092_abnormal_eye_morphology0.68820852
115MP0001188_hyperpigmentation0.68110651
116MP0003942_abnormal_urinary_system0.65986024
117MP0005501_abnormal_skin_physiology0.64883897
118MP0005253_abnormal_eye_physiology0.63395690
119MP0003936_abnormal_reproductive_system0.62847662
120MP0000749_muscle_degeneration0.62764961
121MP0002332_abnormal_exercise_endurance0.61872132
122MP0000490_abnormal_crypts_of0.61708786
123MP0000751_myopathy0.61281677
124MP0003011_delayed_dark_adaptation0.60484249
125MP0003755_abnormal_palate_morphology0.59572344
126MP0003699_abnormal_female_reproductive0.58485433
127MP0005408_hypopigmentation0.56993472

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)5.01890921
2Long foot (HP:0001833)4.94058531
3Neoplasm of the adrenal cortex (HP:0100641)4.84920813
4Birth length less than 3rd percentile (HP:0003561)4.71426681
5High anterior hairline (HP:0009890)4.69858523
6Diastasis recti (HP:0001540)4.56644082
7Breast hypoplasia (HP:0003187)4.21784226
8Neonatal hypoglycemia (HP:0001998)3.98295839
9Abnormal pancreas size (HP:0012094)3.91832368
10Abnormality of glycolysis (HP:0004366)3.80978798
11Increased serum pyruvate (HP:0003542)3.80978798
12Carpal bone hypoplasia (HP:0001498)3.77764396
13Cerebral hypomyelination (HP:0006808)3.69081998
14Neoplasm of the adrenal gland (HP:0100631)3.62838549
15Abnormality of the labia minora (HP:0012880)3.57617819
16Nephroblastoma (Wilms tumor) (HP:0002667)3.40619962
17Microvesicular hepatic steatosis (HP:0001414)3.35156681
18Absent radius (HP:0003974)3.30943818
19Progressive macrocephaly (HP:0004481)3.24151223
20Embryonal renal neoplasm (HP:0011794)3.23336259
21Aplasia involving forearm bones (HP:0009822)3.13015615
22Absent forearm bone (HP:0003953)3.13015615
23Partial agenesis of the corpus callosum (HP:0001338)3.10389768
24Lipid accumulation in hepatocytes (HP:0006561)3.07468818
25Supernumerary spleens (HP:0009799)3.07187611
26Cerebral edema (HP:0002181)3.06494443
27Reticulocytopenia (HP:0001896)3.06109575
28Type I transferrin isoform profile (HP:0003642)3.06039856
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.95062192
30Patellar aplasia (HP:0006443)2.93808635
31Degeneration of anterior horn cells (HP:0002398)2.93772211
32Abnormality of the anterior horn cell (HP:0006802)2.93772211
33Meckel diverticulum (HP:0002245)2.93055582
34Abnormality of the ileum (HP:0001549)2.81105978
35Abnormality of methionine metabolism (HP:0010901)2.80244567
36Aplasia/Hypoplasia of the patella (HP:0006498)2.79641958
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77223153
38Absent thumb (HP:0009777)2.77084488
39Lactic acidosis (HP:0003128)2.76470364
40Rough bone trabeculation (HP:0100670)2.72056498
41Abnormal protein glycosylation (HP:0012346)2.69119934
42Abnormal glycosylation (HP:0012345)2.69119934
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69119934
44Abnormal protein N-linked glycosylation (HP:0012347)2.69119934
45Abnormality of the preputium (HP:0100587)2.60350646
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.56985533
47Aplasia/Hypoplasia involving the musculature (HP:0001460)2.56700651
48Hyperglycinemia (HP:0002154)2.52433624
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52236846
50Abnormality of serum amino acid levels (HP:0003112)2.46943544
51Chromsome breakage (HP:0040012)2.46357429
52Acute necrotizing encephalopathy (HP:0006965)2.46110247
53Abnormality of the septum pellucidum (HP:0007375)2.45770523
54Cortical dysplasia (HP:0002539)2.44765955
55Increased intramyocellular lipid droplets (HP:0012240)2.44728090
56Renal Fanconi syndrome (HP:0001994)2.44074951
57Reduced antithrombin III activity (HP:0001976)2.42661886
58Progressive external ophthalmoplegia (HP:0000590)2.41859898
59Respiratory difficulties (HP:0002880)2.40345225
60Oral leukoplakia (HP:0002745)2.39247221
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37536526
62Respiratory failure (HP:0002878)2.35875558
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33542652
64Abnormal lung lobation (HP:0002101)2.32704363
65Distal lower limb muscle weakness (HP:0009053)2.30591541
66Horseshoe kidney (HP:0000085)2.30470055
67Mitochondrial inheritance (HP:0001427)2.30291787
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.29571999
69Hypoplastic pelvis (HP:0008839)2.28699941
70Hepatocellular necrosis (HP:0001404)2.27522305
71Triphalangeal thumb (HP:0001199)2.27370456
72Abnormality of abdominal situs (HP:0011620)2.27236303
73Abdominal situs inversus (HP:0003363)2.27236303
74Rhabdomyosarcoma (HP:0002859)2.27022541
75Increased serum lactate (HP:0002151)2.26907474
763-Methylglutaconic aciduria (HP:0003535)2.26008306
77Impulsivity (HP:0100710)2.22176513
78Abnormality of pyrimidine metabolism (HP:0004353)2.21303249
79Enlarged kidneys (HP:0000105)2.21253899
80Abnormal mitochondria in muscle tissue (HP:0008316)2.19806976
81Selective tooth agenesis (HP:0001592)2.19157688
82Poor coordination (HP:0002370)2.18516232
83Secondary amenorrhea (HP:0000869)2.18410015
84Overgrowth (HP:0001548)2.16803874
85Ependymoma (HP:0002888)2.16336069
86Duodenal stenosis (HP:0100867)2.15239224
87Small intestinal stenosis (HP:0012848)2.15239224
88Large hands (HP:0001176)2.14409475
89Postnatal microcephaly (HP:0005484)2.14055820
90Increased CSF lactate (HP:0002490)2.12073188
91Abnormal glucose tolerance (HP:0001952)2.10738219
92Abnormality of chromosome stability (HP:0003220)2.09022783
93Leukodystrophy (HP:0002415)2.07666516
94Methylmalonic acidemia (HP:0002912)2.07075533
95Abnormality of the duodenum (HP:0002246)2.04782889
96Methylmalonic aciduria (HP:0012120)2.03991374
97CNS demyelination (HP:0007305)2.03597370
98Premature ovarian failure (HP:0008209)2.01338593
99Genu varum (HP:0002970)1.99744212
100Duplicated collecting system (HP:0000081)1.99305634
101Amniotic constriction ring (HP:0009775)1.95423151
102Abnormality of placental membranes (HP:0011409)1.95423151
103Hepatic necrosis (HP:0002605)1.95334559
104Lethargy (HP:0001254)1.95055724
105Aplasia/hypoplasia of the humerus (HP:0006507)1.93924838
106Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93798385
107Acute encephalopathy (HP:0006846)1.93577143
108Increased hepatocellular lipid droplets (HP:0006565)1.93391885
109Multiple enchondromatosis (HP:0005701)1.92065272
110Pancytopenia (HP:0001876)1.91488102
111Optic disc pallor (HP:0000543)1.91149057
112Abnormality of glycine metabolism (HP:0010895)1.90537754
113Abnormality of serine family amino acid metabolism (HP:0010894)1.90537754
11411 pairs of ribs (HP:0000878)1.90390292
115Abnormal gallbladder physiology (HP:0012438)1.89228179
116Cholecystitis (HP:0001082)1.89228179
117Abnormality of alanine metabolism (HP:0010916)1.88835986
118Hyperalaninemia (HP:0003348)1.88835986
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88835986
120Abnormal trabecular bone morphology (HP:0100671)1.85642161
121Macrocytic anemia (HP:0001972)1.85614574
122Bifid tongue (HP:0010297)1.85506394
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.85495498
124Increased muscle lipid content (HP:0009058)1.85474413
125Tongue fasciculations (HP:0001308)1.84423921
126Trismus (HP:0000211)1.83901850
127Agnosia (HP:0010524)1.83285576
128CNS hypomyelination (HP:0003429)1.83020335
129Colon cancer (HP:0003003)1.82407622
130Spinal muscular atrophy (HP:0007269)1.81870801
131Hyperglycinuria (HP:0003108)1.81832843
132Sloping forehead (HP:0000340)1.80651336
133Exercise intolerance (HP:0003546)1.80447625
134Germ cell neoplasia (HP:0100728)1.80229765
135Rectal fistula (HP:0100590)1.78469960
136Rectovaginal fistula (HP:0000143)1.78469960
137External ophthalmoplegia (HP:0000544)1.78262517
138Delusions (HP:0000746)1.77844758
139Megaloblastic anemia (HP:0001889)1.77707188
140Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77702260
141Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77702260
142Medulloblastoma (HP:0002885)1.76747147
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.76686992
144Neoplasm of the colon (HP:0100273)1.76614693
145Embryonal neoplasm (HP:0002898)1.76241744
146Emotional lability (HP:0000712)1.76139686
147Increased nuchal translucency (HP:0010880)1.74181235
148Abnormal number of erythroid precursors (HP:0012131)1.72815948
149Prominent metopic ridge (HP:0005487)1.69439803
150Volvulus (HP:0002580)1.68727193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.17204202
2BUB14.92244554
3WEE13.98669942
4EIF2AK13.84802697
5VRK23.50209230
6NEK13.40263691
7MKNK22.63625655
8TRIM282.61100716
9CDC72.55523012
10TESK22.55212706
11SRPK12.48920457
12TSSK62.32754735
13PLK42.25502559
14TLK12.14720361
15MKNK12.11859536
16MST42.11858289
17TTK2.09290539
18PLK11.83991379
19PRKG21.78315665
20EIF2AK31.65730917
21BRSK21.55697805
22TESK11.55006468
23STK38L1.52107722
24NEK21.49483346
25EPHA21.44739509
26DYRK21.42583607
27WNK31.36970779
28MAP4K21.36426732
29LIMK11.36141706
30AURKA1.35971829
31BRSK11.33662974
32PLK31.33484100
33VRK11.30664837
34CDK191.27462167
35NUAK11.26287871
36MARK11.25604315
37PDK41.22796833
38PDK31.22796833
39BCKDK1.19788799
40CSNK1G11.15786918
41PNCK1.15225252
42PAK41.14771594
43CDK71.14266620
44TAF11.10868159
45NME11.08550423
46NME21.06367006
47CCNB11.05531952
48LATS21.05123494
49ATR1.04855693
50BMPR1B1.01906237
51AURKB1.01122233
52CHEK20.99783508
53MAP2K70.99588049
54RPS6KB20.98933918
55CSNK1A1L0.98431131
56CSNK1G20.97687661
57PBK0.97151884
58DYRK30.93389966
59SIK30.91586570
60PLK20.90237695
61PRKCI0.89804524
62MAP3K120.89699852
63ZAK0.88909325
64ALK0.86993276
65ACVR1B0.85645747
66CHEK10.81966990
67CAMK2B0.80430778
68CDK120.77885089
69BRAF0.76855730
70MAPKAPK30.76301104
71MINK10.74769417
72MAP3K40.70461522
73AKT30.69780696
74MAP3K110.69220145
75RPS6KA40.68323077
76PASK0.66775398
77EIF2AK20.66152618
78CDK80.65614199
79DAPK10.64123506
80UHMK10.64033100
81MAP3K80.63533446
82NTRK20.61686002
83TNIK0.61405743
84ATM0.60056990
85ERBB40.59949447
86PDK20.59285071
87PIM20.57513275
88ARAF0.57325968
89KDR0.57062644
90CAMK2G0.55855785
91CSNK2A10.55584742
92CAMK2D0.55474459
93PAK10.55443856
94CDK20.54932294
95CSNK2A20.54882161
96BCR0.54856747
97CSNK1E0.52592812
98CASK0.50758648
99SCYL20.48789451
100CSNK1G30.48162988
101CDK140.47635307
102CDK10.47555584
103TIE10.47066299
104IRAK30.45736982
105CDK180.45122410
106OXSR10.42591442
107NEK90.41455708
108CDK150.41069501
109CLK10.39500191
110DAPK30.37670250
111MYLK0.36729401
112CDK11A0.36167491
113OBSCN0.35348845
114EPHA40.35184162
115MAPKAPK50.34938419
116PRKCG0.31656988
117RPS6KA50.30827392
118AKT20.30601964
119STK40.30514586
120CDK40.30488530
121TGFBR10.29091588
122CDK30.28488195
123IRAK20.28244439
124ERBB30.24996117
125FER0.24379989
126FGFR10.23884243
127PRKDC0.23523332
128DYRK1A0.18510931
129MELK0.17924258
130ABL20.17711744
131STK100.15575157
132STK240.15320065

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.60866709
2DNA replication_Homo sapiens_hsa030304.54537543
3Mismatch repair_Homo sapiens_hsa034304.08405533
4RNA polymerase_Homo sapiens_hsa030203.51662658
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51659872
6Ribosome_Homo sapiens_hsa030103.06322852
7Spliceosome_Homo sapiens_hsa030403.04578984
8RNA transport_Homo sapiens_hsa030132.91717446
9One carbon pool by folate_Homo sapiens_hsa006702.79078221
10Nucleotide excision repair_Homo sapiens_hsa034202.63862057
11Homologous recombination_Homo sapiens_hsa034402.62428070
12Base excision repair_Homo sapiens_hsa034102.62070930
13Pyrimidine metabolism_Homo sapiens_hsa002402.47304700
14Cell cycle_Homo sapiens_hsa041102.26443222
15Oxidative phosphorylation_Homo sapiens_hsa001902.22961710
16Fanconi anemia pathway_Homo sapiens_hsa034602.14889854
17Parkinsons disease_Homo sapiens_hsa050122.13727978
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12383585
19Basal transcription factors_Homo sapiens_hsa030222.01262244
20Huntingtons disease_Homo sapiens_hsa050161.99746317
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80825245
22RNA degradation_Homo sapiens_hsa030181.63870623
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55837456
24Biosynthesis of amino acids_Homo sapiens_hsa012301.40460689
25mRNA surveillance pathway_Homo sapiens_hsa030151.37503346
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.36543427
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.32586076
28Non-homologous end-joining_Homo sapiens_hsa034501.30298535
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28868914
30Purine metabolism_Homo sapiens_hsa002301.28764527
31Alzheimers disease_Homo sapiens_hsa050101.21045574
32Oocyte meiosis_Homo sapiens_hsa041141.20632530
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19168699
34Epstein-Barr virus infection_Homo sapiens_hsa051691.13736950
35Carbon metabolism_Homo sapiens_hsa012001.12668004
36Vitamin B6 metabolism_Homo sapiens_hsa007501.11909696
37Cardiac muscle contraction_Homo sapiens_hsa042601.02241189
38p53 signaling pathway_Homo sapiens_hsa041150.99834891
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99280246
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95964896
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95683413
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88659940
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84559774
44Pyruvate metabolism_Homo sapiens_hsa006200.78382082
45Glutathione metabolism_Homo sapiens_hsa004800.76076516
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75845198
47N-Glycan biosynthesis_Homo sapiens_hsa005100.73704310
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72278883
49Fructose and mannose metabolism_Homo sapiens_hsa000510.70398829
50Folate biosynthesis_Homo sapiens_hsa007900.69380168
51Fatty acid metabolism_Homo sapiens_hsa012120.68248521
52Selenocompound metabolism_Homo sapiens_hsa004500.67168563
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.66539702
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66474317
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65998944
56Pentose phosphate pathway_Homo sapiens_hsa000300.59136715
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58792732
58Protein export_Homo sapiens_hsa030600.57399231
59Peroxisome_Homo sapiens_hsa041460.57018497
60Butanoate metabolism_Homo sapiens_hsa006500.55342672
61Sulfur relay system_Homo sapiens_hsa041220.55282045
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.54971786
63Viral carcinogenesis_Homo sapiens_hsa052030.48726150
64Metabolic pathways_Homo sapiens_hsa011000.48534000
65Systemic lupus erythematosus_Homo sapiens_hsa053220.46755091
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46672308
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46043017
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42053653
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41715884
70beta-Alanine metabolism_Homo sapiens_hsa004100.41660676
71Sulfur metabolism_Homo sapiens_hsa009200.41554926
72Collecting duct acid secretion_Homo sapiens_hsa049660.39457393
73Arginine and proline metabolism_Homo sapiens_hsa003300.37559176
74Hippo signaling pathway_Homo sapiens_hsa043900.36997898
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36653938
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36039022
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33686943
78Galactose metabolism_Homo sapiens_hsa000520.33375788
79Fatty acid degradation_Homo sapiens_hsa000710.31817092
80Basal cell carcinoma_Homo sapiens_hsa052170.30498454
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29760624
82Thyroid cancer_Homo sapiens_hsa052160.28850898
83Synaptic vesicle cycle_Homo sapiens_hsa047210.24967290
84Phenylalanine metabolism_Homo sapiens_hsa003600.24200032
85Lysine degradation_Homo sapiens_hsa003100.24174141
86HTLV-I infection_Homo sapiens_hsa051660.23225575
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22942682
88Hedgehog signaling pathway_Homo sapiens_hsa043400.22247524
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.20895091
90Arginine biosynthesis_Homo sapiens_hsa002200.20376354
91Herpes simplex infection_Homo sapiens_hsa051680.20361450
92Vibrio cholerae infection_Homo sapiens_hsa051100.20178267
93Phototransduction_Homo sapiens_hsa047440.18577872
94Propanoate metabolism_Homo sapiens_hsa006400.18228353
95Tryptophan metabolism_Homo sapiens_hsa003800.16889474
96Tyrosine metabolism_Homo sapiens_hsa003500.15763298
97HIF-1 signaling pathway_Homo sapiens_hsa040660.15305713
98Alcoholism_Homo sapiens_hsa050340.14382880
99TGF-beta signaling pathway_Homo sapiens_hsa043500.12487425
100African trypanosomiasis_Homo sapiens_hsa051430.11500879
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.11443803
102Vitamin digestion and absorption_Homo sapiens_hsa049770.11440178
103Fat digestion and absorption_Homo sapiens_hsa049750.11349088
104Wnt signaling pathway_Homo sapiens_hsa043100.10106978
105Tight junction_Homo sapiens_hsa045300.09731492
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.07420666
107Legionellosis_Homo sapiens_hsa051340.06895649
108Steroid biosynthesis_Homo sapiens_hsa001000.06685365
109Gap junction_Homo sapiens_hsa045400.06662617
110Colorectal cancer_Homo sapiens_hsa052100.05836253
111Shigellosis_Homo sapiens_hsa051310.05588757
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05587555
113Arachidonic acid metabolism_Homo sapiens_hsa005900.04999283
114Fatty acid elongation_Homo sapiens_hsa000620.03561285
115MicroRNAs in cancer_Homo sapiens_hsa052060.02791210
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.02070063
117Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.01648985
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.01545886
119Regulation of autophagy_Homo sapiens_hsa041400.01011893

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