CHTOP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.29871805
2negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.68880442
3negative regulation of RNA splicing (GO:0033119)4.28815535
4positive regulation of mitochondrial fission (GO:0090141)4.12225291
5pre-miRNA processing (GO:0031054)3.97691788
6negative regulation of mRNA processing (GO:0050686)3.92162870
7establishment of mitochondrion localization (GO:0051654)3.86914638
8nuclear pore organization (GO:0006999)3.78508462
9peptidyl-lysine dimethylation (GO:0018027)3.77248065
10nuclear pore complex assembly (GO:0051292)3.73397261
11base-excision repair, AP site formation (GO:0006285)3.73105135
12protein localization to kinetochore (GO:0034501)3.70860419
13negative regulation of histone methylation (GO:0031061)3.65457325
14dosage compensation (GO:0007549)3.60645362
15pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.55173577
16negative regulation of mRNA metabolic process (GO:1903312)3.54868291
17regulation of RNA export from nucleus (GO:0046831)3.53115542
18regulation of mRNA splicing, via spliceosome (GO:0048024)3.51743160
19pyrimidine nucleobase catabolic process (GO:0006208)3.50409609
20DNA replication-dependent nucleosome assembly (GO:0006335)3.45632899
21DNA replication-dependent nucleosome organization (GO:0034723)3.45632899
22histone H4-K8 acetylation (GO:0043982)3.45252009
23histone H4-K5 acetylation (GO:0043981)3.45252009
24regulation of translational fidelity (GO:0006450)3.45133556
25mitotic sister chromatid cohesion (GO:0007064)3.45087239
26histone H4-K16 acetylation (GO:0043984)3.41592677
27spliceosomal tri-snRNP complex assembly (GO:0000244)3.40437706
28regulation of sister chromatid cohesion (GO:0007063)3.39899377
29DNA duplex unwinding (GO:0032508)3.39400725
30mitotic chromosome condensation (GO:0007076)3.38732406
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33010251
32DNA geometric change (GO:0032392)3.32256278
33pyrimidine nucleotide catabolic process (GO:0006244)3.30411360
34protein localization to chromosome, centromeric region (GO:0071459)3.30169963
35mitotic nuclear envelope disassembly (GO:0007077)3.28984933
36tRNA methylation (GO:0030488)3.28489515
37positive regulation of receptor biosynthetic process (GO:0010870)3.27223759
38membrane disassembly (GO:0030397)3.21796488
39nuclear envelope disassembly (GO:0051081)3.21796488
40peptidyl-arginine omega-N-methylation (GO:0035247)3.20273999
41sister chromatid segregation (GO:0000819)3.20016231
42negative regulation of cell cycle G2/M phase transition (GO:1902750)3.19000813
43peptidyl-arginine N-methylation (GO:0035246)3.18910365
44peptidyl-arginine methylation (GO:0018216)3.18910365
45* RNA export from nucleus (GO:0006405)3.14614573
46mitochondrial RNA metabolic process (GO:0000959)3.14114645
47* mRNA export from nucleus (GO:0006406)3.12781973
48mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.11938227
49translesion synthesis (GO:0019985)3.11614204
50RNA stabilization (GO:0043489)3.11081136
51mRNA stabilization (GO:0048255)3.11081136
52DNA strand elongation involved in DNA replication (GO:0006271)3.10861268
53telomere maintenance via semi-conservative replication (GO:0032201)3.10704466
54protein-DNA complex disassembly (GO:0032986)3.09161037
55nucleosome disassembly (GO:0006337)3.09161037
56establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.08921554
57mitochondrion transport along microtubule (GO:0047497)3.08921554
58regulation of histone H3-K9 methylation (GO:0051570)3.08247908
59base-excision repair (GO:0006284)3.07355675
60regulation of mitochondrial fission (GO:0090140)3.05855571
61glucocorticoid receptor signaling pathway (GO:0042921)3.04630359
62regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.02487758
633-UTR-mediated mRNA stabilization (GO:0070935)2.96223603
64nuclear envelope reassembly (GO:0031468)2.96101721
65mitotic nuclear envelope reassembly (GO:0007084)2.96101721
66alternative mRNA splicing, via spliceosome (GO:0000380)2.95399883
67regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.94012354
68DNA replication initiation (GO:0006270)2.93403499
69snRNA metabolic process (GO:0016073)2.89306762
70snRNA processing (GO:0016180)2.89067606
71histone H3 deacetylation (GO:0070932)2.88824897
72DNA strand elongation (GO:0022616)2.88331164
73regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.87483307
74mitotic G1 DNA damage checkpoint (GO:0031571)2.86948037
75peptidyl-histidine modification (GO:0018202)2.86022576
76ribosome biogenesis (GO:0042254)2.85599962
77RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.84762042
78mRNA splicing, via spliceosome (GO:0000398)2.84762042
79regulation of RNA splicing (GO:0043484)2.84595284
80heterochromatin organization (GO:0070828)2.84028523
81histone H4 deacetylation (GO:0070933)2.82940000
82iron-sulfur cluster assembly (GO:0016226)2.81820521
83metallo-sulfur cluster assembly (GO:0031163)2.81820521
84de novo posttranslational protein folding (GO:0051084)2.79161753
85DNA topological change (GO:0006265)2.78953800
86RNA splicing (GO:0008380)2.78571854
87regulation of double-strand break repair via homologous recombination (GO:0010569)2.78219202
88regulation of chromatin binding (GO:0035561)2.78202542
89negative regulation of gene expression, epigenetic (GO:0045814)2.77336695
90nuclear envelope organization (GO:0006998)2.76953880
91RNA splicing, via transesterification reactions (GO:0000375)2.76699660
92regulation of nucleobase-containing compound transport (GO:0032239)2.76147662
93pseudouridine synthesis (GO:0001522)2.75155424
94embryonic foregut morphogenesis (GO:0048617)2.74945429
95tRNA modification (GO:0006400)2.74857016
96folic acid-containing compound biosynthetic process (GO:0009396)2.74809691
97regulation of mRNA stability (GO:0043488)2.74396510
98regulation of oxidative stress-induced neuron death (GO:1903203)2.74319717
99negative regulation of DNA-templated transcription, elongation (GO:0032785)2.73989586
100negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.72005482
101histone H4 acetylation (GO:0043967)2.71923773
102regulation of DNA damage checkpoint (GO:2000001)2.71255462
103NLS-bearing protein import into nucleus (GO:0006607)2.70616479
104positive regulation of RNA splicing (GO:0033120)2.70553275
105ubiquinone metabolic process (GO:0006743)2.70057389
106mitochondrial fusion (GO:0008053)2.69433527
107planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69181646
108de novo protein folding (GO:0006458)2.69141921
109mRNA splice site selection (GO:0006376)2.69040225
110ncRNA 3-end processing (GO:0043628)2.68161984
111nucleotide-excision repair, DNA gap filling (GO:0006297)2.65760755
112pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.65553564
113termination of RNA polymerase II transcription (GO:0006369)2.65547620
114chromatin assembly or disassembly (GO:0006333)2.65240823
115regulation of translational termination (GO:0006449)2.64568986
116intracellular estrogen receptor signaling pathway (GO:0030520)2.62466850
117protein complex localization (GO:0031503)2.62035659
118histone H2A acetylation (GO:0043968)2.62013877
119positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.61987300
120histone H2A monoubiquitination (GO:0035518)2.61986982
121chromatin silencing (GO:0006342)2.61732141
122mitotic sister chromatid segregation (GO:0000070)2.61547951
123ATP-dependent chromatin remodeling (GO:0043044)2.60605665
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.60504925
125ubiquinone biosynthetic process (GO:0006744)2.60417457
126rRNA transcription (GO:0009303)2.60417161
127telomere maintenance via recombination (GO:0000722)2.60288853
128spliceosomal snRNP assembly (GO:0000387)2.59917360
129gene silencing (GO:0016458)2.59548037
130negative regulation of Notch signaling pathway (GO:0045746)2.59336696
131protein insertion into membrane (GO:0051205)2.58065078
132regulation of spindle organization (GO:0090224)2.57868696
133gene silencing by RNA (GO:0031047)2.57563682
134chromatin assembly (GO:0031497)2.57383200
135ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.57154912
136regulation of chromosome segregation (GO:0051983)2.56824462
137negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.56655313
138hippo signaling (GO:0035329)2.56473754
139DNA conformation change (GO:0071103)2.55854185
140regulation of RNA stability (GO:0043487)2.55131478
141regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54133526
142regulation of mRNA processing (GO:0050684)2.53752373
143positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.52939790
144negative regulation of chromosome segregation (GO:0051985)2.52760129
145regulation of telomere maintenance via telomerase (GO:0032210)2.52345115
146mitotic spindle assembly checkpoint (GO:0007094)2.52078075
147Golgi transport vesicle coating (GO:0048200)2.51958442
148COPI coating of Golgi vesicle (GO:0048205)2.51958442
149paraxial mesoderm development (GO:0048339)2.51855380
150protein localization to chromosome (GO:0034502)2.51787546
151regulation of NFAT protein import into nucleus (GO:0051532)2.50458448
152histone arginine methylation (GO:0034969)2.50351082
153spindle assembly checkpoint (GO:0071173)2.48748451
154mitochondrion localization (GO:0051646)2.48586445
155L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.48326599
156* mRNA transport (GO:0051028)2.47835915
157negative regulation of mitotic sister chromatid separation (GO:2000816)2.47292980
158negative regulation of mitotic sister chromatid segregation (GO:0033048)2.47292980
159negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.47292980
160negative regulation of sister chromatid segregation (GO:0033046)2.47292980
161mitotic metaphase plate congression (GO:0007080)2.47220445
162regulation of centriole replication (GO:0046599)2.46665895
163mRNA processing (GO:0006397)2.46173803
164proximal/distal pattern formation (GO:0009954)2.44238396
165mRNA 3-end processing (GO:0031124)2.43575943
166establishment of viral latency (GO:0019043)2.43523624
167poly(A)+ mRNA export from nucleus (GO:0016973)2.42773257

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.85009166
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.00641632
3MYC_22102868_ChIP-Seq_BL_Human3.67520191
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.66702130
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.11327181
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07180628
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.03215796
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98321048
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.91215166
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.86133748
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.82785218
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.64552950
13DCP1A_22483619_ChIP-Seq_HELA_Human2.47415780
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46053712
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.36454874
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35466781
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28555426
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.25894152
19CIITA_25753668_ChIP-Seq_RAJI_Human2.17931051
20VDR_21846776_ChIP-Seq_THP-1_Human2.16041270
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.08776535
22XRN2_22483619_ChIP-Seq_HELA_Human2.07031427
23FOXP3_21729870_ChIP-Seq_TREG_Human2.04448687
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.97051153
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94749506
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93948792
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91761260
28KDM2B_26808549_Chip-Seq_DND41_Human1.91733335
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.91462578
30BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.89480330
31ZNF263_19887448_ChIP-Seq_K562_Human1.88770901
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88603808
33TCF7_22412390_ChIP-Seq_EML_Mouse1.87880432
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.87357000
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86886519
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86188509
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.84538450
38AR_21909140_ChIP-Seq_LNCAP_Human1.83253373
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82692470
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.80514246
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77698802
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75853757
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75375737
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.73568817
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72209638
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71315622
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67675659
48* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65171520
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61642942
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60869098
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.56481981
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55499376
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.55389863
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.55117885
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49400839
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48988522
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46861786
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.42899241
59KDM5A_27292631_Chip-Seq_BREAST_Human1.41298732
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40824167
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.40715477
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40201769
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39978315
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39909530
65UTX_26944678_Chip-Seq_JUKART_Human1.39206376
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38813702
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37237073
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.37161602
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.37055296
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36775828
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35894987
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34140493
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32862440
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30607094
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29828138
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29458943
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29061674
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28869905
79ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28841755
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28749788
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.27601042
82MAF_26560356_Chip-Seq_TH1_Human1.26490340
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26120092
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25873436
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25635227
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25446347
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25441444
88CHD1_26751641_Chip-Seq_LNCaP_Human1.24253759
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22586888
90IGF1R_20145208_ChIP-Seq_DFB_Human1.20567790
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20455706
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18975429
93POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18597286
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18156178
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17457071
96GABP_19822575_ChIP-Seq_HepG2_Human1.17060616
97TTF2_22483619_ChIP-Seq_HELA_Human1.16709444
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16334077
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15344597
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14823646
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14169423
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13684743
103ELK1_19687146_ChIP-ChIP_HELA_Human1.12648108
104STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12320490
105PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12135771
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11808339
107NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11616365
108CLOCK_20551151_ChIP-Seq_293T_Human1.11505368
109SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11306267
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10479510
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09684816
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09574642
113LXR_22292898_ChIP-Seq_THP-1_Human1.09405595
114SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08903631
115THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07768801
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06855276
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06324769
118MYC_18940864_ChIP-ChIP_HL60_Human1.04690028
119ATF3_27146783_Chip-Seq_COLON_Human1.04051800
120CREB1_26743006_Chip-Seq_LNCaP_Human1.02413787
121ETS1_20019798_ChIP-Seq_JURKAT_Human1.02288276
122NCOR1_26117541_ChIP-Seq_K562_Human1.01803993
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00579115
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99698355
125TET1_21451524_ChIP-Seq_MESCs_Mouse0.99116848
126VDR_23849224_ChIP-Seq_CD4+_Human0.98319703
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.97583235
128SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96314684
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96255930
130KDM2B_26808549_Chip-Seq_K562_Human0.94806171
131E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92845075
132TFEB_21752829_ChIP-Seq_HELA_Human0.92684707
133FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92606770
134MAF_26560356_Chip-Seq_TH2_Human0.92595012
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92578551
136* FOXP1_21924763_ChIP-Seq_HESCs_Human0.92350108
137SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91832267
138EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91804886
139CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91667662
140P68_20966046_ChIP-Seq_HELA_Human0.90451872
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89613076
142NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89148839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.55315903
2MP0010352_gastrointestinal_tract_polyps2.88901984
3MP0010094_abnormal_chromosome_stability2.79278029
4MP0003111_abnormal_nucleus_morphology2.74488980
5MP0010030_abnormal_orbit_morphology2.62950894
6MP0003077_abnormal_cell_cycle2.62652758
7MP0003221_abnormal_cardiomyocyte_apopto2.62473114
8MP0003283_abnormal_digestive_organ2.59988806
9MP0004957_abnormal_blastocyst_morpholog2.59005648
10MP0005076_abnormal_cell_differentiation2.52989864
11MP0003693_abnormal_embryo_hatching2.47494107
12MP0002822_catalepsy2.37919362
13MP0010234_abnormal_vibrissa_follicle2.36691209
14MP0003705_abnormal_hypodermis_morpholog2.36351219
15MP0001730_embryonic_growth_arrest2.25816516
16MP0009053_abnormal_anal_canal2.16515215
17MP0000350_abnormal_cell_proliferation2.12973278
18MP0008057_abnormal_DNA_replication2.10842439
19MP0002009_preneoplasia2.09888458
20MP0006035_abnormal_mitochondrial_morpho2.08490578
21MP0003123_paternal_imprinting2.07629172
22MP0008007_abnormal_cellular_replicative2.02775067
23MP0002102_abnormal_ear_morphology1.93463718
24MP0002084_abnormal_developmental_patter1.91489168
25MP0004197_abnormal_fetal_growth/weight/1.90376703
26MP0008995_early_reproductive_senescence1.87808636
27MP0002249_abnormal_larynx_morphology1.83506329
28MP0003786_premature_aging1.80574888
29MP0005187_abnormal_penis_morphology1.80566856
30MP0003119_abnormal_digestive_system1.79078939
31MP0002085_abnormal_embryonic_tissue1.75811069
32MP0001697_abnormal_embryo_size1.73259283
33MP0006054_spinal_hemorrhage1.72949060
34MP0000428_abnormal_craniofacial_morphol1.72891348
35MP0001293_anophthalmia1.70566454
36MP0005380_embryogenesis_phenotype1.66614280
37MP0001672_abnormal_embryogenesis/_devel1.66614280
38MP0002396_abnormal_hematopoietic_system1.65613938
39MP0003121_genomic_imprinting1.63660537
40MP0002653_abnormal_ependyma_morphology1.63535372
41MP0000733_abnormal_muscle_development1.58223821
42MP0001188_hyperpigmentation1.57041807
43MP0001849_ear_inflammation1.56522507
44MP0003984_embryonic_growth_retardation1.55641580
45MP0008058_abnormal_DNA_repair1.55133513
46MP0002088_abnormal_embryonic_growth/wei1.54297083
47MP0002234_abnormal_pharynx_morphology1.53410258
48MP0004233_abnormal_muscle_weight1.53194005
49MP0003890_abnormal_embryonic-extraembry1.53051023
50MP0002080_prenatal_lethality1.52220481
51MP0008932_abnormal_embryonic_tissue1.47721160
52MP0003115_abnormal_respiratory_system1.44918134
53MP0000750_abnormal_muscle_regeneration1.44567677
54MP0006036_abnormal_mitochondrial_physio1.44532161
55MP0002086_abnormal_extraembryonic_tissu1.44333808
56MP0008961_abnormal_basal_metabolism1.44005022
57MP0009672_abnormal_birth_weight1.42136251
58MP0006292_abnormal_olfactory_placode1.38656011
59MP0002277_abnormal_respiratory_mucosa1.38481344
60MP0010307_abnormal_tumor_latency1.37172157
61MP0003315_abnormal_perineum_morphology1.37021059
62MP0005083_abnormal_biliary_tract1.33693335
63MP0003763_abnormal_thymus_physiology1.33516747
64MP0009278_abnormal_bone_marrow1.32129720
65MP0004133_heterotaxia1.28038193
66MP0001270_distended_abdomen1.27909021
67MP0003300_gastrointestinal_ulcer1.26567871
68MP0002092_abnormal_eye_morphology1.25790391
69MP0000703_abnormal_thymus_morphology1.22983731
70MP0009703_decreased_birth_body1.22178491
71MP0003861_abnormal_nervous_system1.20691493
72MP0003567_abnormal_fetal_cardiomyocyte1.17221324
73MP0004808_abnormal_hematopoietic_stem1.17109886
74MP0001529_abnormal_vocalization1.16223561
75MP0002932_abnormal_joint_morphology1.16208594
76MP0003942_abnormal_urinary_system1.15624598
77MP0000534_abnormal_ureter_morphology1.14699951
78MP0004811_abnormal_neuron_physiology1.14410659
79MP0000751_myopathy1.11812258
80MP0002210_abnormal_sex_determination1.10559639
81MP0003935_abnormal_craniofacial_develop1.10238942
82MP0008260_abnormal_autophagy1.10147590
83MP0003938_abnormal_ear_development1.09127278
84MP0002089_abnormal_postnatal_growth/wei1.08939881
85MP0005248_abnormal_Harderian_gland1.05732718
86MP0001929_abnormal_gametogenesis1.04310239
87MP0005645_abnormal_hypothalamus_physiol1.02382952
88MP0000313_abnormal_cell_death0.99772455
89MP0003937_abnormal_limbs/digits/tail_de0.98150516
90MP0008877_abnormal_DNA_methylation0.97670083
91MP0000569_abnormal_digit_pigmentation0.97249638
92MP0002098_abnormal_vibrissa_morphology0.96960965
93MP0003122_maternal_imprinting0.96951056
94MP0003303_peritoneal_inflammation0.96910206
95MP0000490_abnormal_crypts_of0.96740631
96MP0001502_abnormal_circadian_rhythm0.95953559
97MP0002269_muscular_atrophy0.95604630
98MP0003698_abnormal_male_reproductive0.95261877
99MP0003787_abnormal_imprinting0.95151135
100MP0001145_abnormal_male_reproductive0.94726437
101MP0002019_abnormal_tumor_incidence0.94611875
102MP0002925_abnormal_cardiovascular_devel0.93977719
103MP0000759_abnormal_skeletal_muscle0.93799975
104MP0002697_abnormal_eye_size0.93744908
105MP0002332_abnormal_exercise_endurance0.93568080
106MP0002111_abnormal_tail_morphology0.92129960
107MP0002106_abnormal_muscle_physiology0.90100703
108MP0003385_abnormal_body_wall0.89420232
109MP0000747_muscle_weakness0.89098652
110MP0005623_abnormal_meninges_morphology0.88838564
111MP0006072_abnormal_retinal_apoptosis0.85605122
112MP0002081_perinatal_lethality0.84730468
113MP0004185_abnormal_adipocyte_glucose0.84486665
114MP0001299_abnormal_eye_distance/0.84398433
115MP0008770_decreased_survivor_rate0.83474938
116MP0000631_abnormal_neuroendocrine_gland0.83405065
117MP0000358_abnormal_cell_content/0.82422849
118MP0002722_abnormal_immune_system0.81335185
119MP0004859_abnormal_synaptic_plasticity0.81327806
120MP0003755_abnormal_palate_morphology0.81310872
121MP0001346_abnormal_lacrimal_gland0.79900678
122MP0008789_abnormal_olfactory_epithelium0.79669168
123MP0002116_abnormal_craniofacial_bone0.79162938
124MP0006276_abnormal_autonomic_nervous0.78862952
125MP0001764_abnormal_homeostasis0.78424472
126MP0005266_abnormal_metabolism0.78416926
127MP0010678_abnormal_skin_adnexa0.77783715
128MP0002132_abnormal_respiratory_system0.77232851
129MP0000266_abnormal_heart_morphology0.75525615
130MP0005391_vision/eye_phenotype0.75338122
131MP0004147_increased_porphyrin_level0.74995415
132MP0000653_abnormal_sex_gland0.74383105
133MP0000689_abnormal_spleen_morphology0.74147388
134MP0000516_abnormal_urinary_system0.73688638
135MP0005367_renal/urinary_system_phenotyp0.73688638
136MP0000003_abnormal_adipose_tissue0.73116824
137MP0005253_abnormal_eye_physiology0.72404342
138MP0001286_abnormal_eye_development0.72099690
139MP0003646_muscle_fatigue0.70270427
140MP0005499_abnormal_olfactory_system0.70267098
141MP0005394_taste/olfaction_phenotype0.70267098
142MP0010630_abnormal_cardiac_muscle0.70127716
143MP0002152_abnormal_brain_morphology0.69865954
144MP0001915_intracranial_hemorrhage0.69254789
145MP0000955_abnormal_spinal_cord0.69128422
146MP0002114_abnormal_axial_skeleton0.68648758
147MP0000566_synostosis0.68533072
148MP0002751_abnormal_autonomic_nervous0.68411630
149MP0000462_abnormal_digestive_system0.68362134
150MP0005369_muscle_phenotype0.68225709
151MP0000477_abnormal_intestine_morphology0.67802516
152MP0000432_abnormal_head_morphology0.67487661
153MP0000778_abnormal_nervous_system0.67434555
154MP0000049_abnormal_middle_ear0.67128545
155MP0002398_abnormal_bone_marrow0.66840603
156MP0002233_abnormal_nose_morphology0.66469530

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)4.27517131
2Ragged-red muscle fibers (HP:0003200)3.91483737
3Colon cancer (HP:0003003)3.64641423
4Hyperacusis (HP:0010780)3.61309552
5Progressive muscle weakness (HP:0003323)3.60187150
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.52854162
7Short 4th metacarpal (HP:0010044)3.52854162
8Cortical dysplasia (HP:0002539)3.44876527
9Ependymoma (HP:0002888)3.34318774
10Retinal dysplasia (HP:0007973)3.26638998
11Renal duplication (HP:0000075)3.20729834
12Increased nuchal translucency (HP:0010880)3.15781621
13Rimmed vacuoles (HP:0003805)3.06264835
14Abnormality of the astrocytes (HP:0100707)3.04045847
15Astrocytoma (HP:0009592)3.04045847
16Medulloblastoma (HP:0002885)2.86594070
17Pelvic girdle muscle weakness (HP:0003749)2.83992332
18Abnormality of the 4th metacarpal (HP:0010012)2.82017477
19Optic nerve coloboma (HP:0000588)2.76531327
20Overriding aorta (HP:0002623)2.71622946
21Insomnia (HP:0100785)2.64703077
22Progressive microcephaly (HP:0000253)2.63512389
23Volvulus (HP:0002580)2.59814952
24Lissencephaly (HP:0001339)2.59239891
25Selective tooth agenesis (HP:0001592)2.58154635
26Elfin facies (HP:0004428)2.49454315
27Abnormality of the columella (HP:0009929)2.46615442
28Renovascular hypertension (HP:0100817)2.43489763
29Gastrointestinal carcinoma (HP:0002672)2.41987031
30Malignant gastrointestinal tract tumors (HP:0006749)2.41987031
31Glioma (HP:0009733)2.41312155
32Pointed chin (HP:0000307)2.40540551
33Nephrogenic diabetes insipidus (HP:0009806)2.39602933
34Shoulder girdle muscle weakness (HP:0003547)2.39588379
35Abnormality of the hip-girdle musculature (HP:0001445)2.39508971
36Abnormality of the musculature of the pelvis (HP:0001469)2.39508971
37Basal cell carcinoma (HP:0002671)2.38972848
38Trigonocephaly (HP:0000243)2.33231802
39Microretrognathia (HP:0000308)2.31067348
40Myopathic facies (HP:0002058)2.30037433
41Neoplasm of the oral cavity (HP:0100649)2.29334631
42Rectal prolapse (HP:0002035)2.26898337
43Centrally nucleated skeletal muscle fibers (HP:0003687)2.24187273
44Split foot (HP:0001839)2.24031461
45Hypoplasia of the brainstem (HP:0002365)2.20522790
46Aplasia/Hypoplasia of the brainstem (HP:0007362)2.20522790
47Proximal placement of thumb (HP:0009623)2.20319759
48Ankyloglossia (HP:0010296)2.19579998
49Progressive external ophthalmoplegia (HP:0000590)2.18625282
50Gait imbalance (HP:0002141)2.18291725
51Abnormal number of incisors (HP:0011064)2.16474672
52Exercise-induced myalgia (HP:0003738)2.15809104
53Neoplasm of the heart (HP:0100544)2.15420460
54Carpal bone hypoplasia (HP:0001498)2.14441003
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13981409
56Abnormal protein N-linked glycosylation (HP:0012347)2.13981409
57Abnormal protein glycosylation (HP:0012346)2.13981409
58Abnormal glycosylation (HP:0012345)2.13981409
59Overlapping toe (HP:0001845)2.13387982
60Broad palm (HP:0001169)2.12932356
61Congenital primary aphakia (HP:0007707)2.12809266
62Heterotopia (HP:0002282)2.12777613
63Neoplasm of striated muscle (HP:0009728)2.12051927
64Fibroma (HP:0010614)2.11461375
65Fibrous tissue neoplasm (HP:0012316)2.09834685
66Increased serum lactate (HP:0002151)2.08590812
673-Methylglutaconic aciduria (HP:0003535)2.07785335
68Premature ovarian failure (HP:0008209)2.07226547
69Sacral dimple (HP:0000960)2.06677212
70Deviation of the thumb (HP:0009603)2.06068936
71Shallow orbits (HP:0000586)2.04508244
72Severe combined immunodeficiency (HP:0004430)2.04449233
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04384297
74Bowel diverticulosis (HP:0005222)2.01873832
75Cutis marmorata (HP:0000965)2.00931194
76Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.00712894
77High anterior hairline (HP:0009890)2.00485001
78Adenoma sebaceum (HP:0009720)2.00448940
79Angiofibromas (HP:0010615)2.00448940
80Abnormality of oral frenula (HP:0000190)2.00425202
81Subacute progressive viral hepatitis (HP:0006572)2.00131448
82Obsessive-compulsive behavior (HP:0000722)1.99391652
83Limb-girdle muscle atrophy (HP:0003797)1.98007830
84Skin tags (HP:0010609)1.97311442
85Back pain (HP:0003418)1.94685032
86Deep palmar crease (HP:0006191)1.94580599
87Hallux valgus (HP:0001822)1.93835954
88Exercise-induced muscle cramps (HP:0003710)1.93685206
89Urinary urgency (HP:0000012)1.91971108
90Atresia of the external auditory canal (HP:0000413)1.91129252
91Atrophy/Degeneration involving motor neurons (HP:0007373)1.90046927
92Macroorchidism (HP:0000053)1.89148769
93Self-mutilation (HP:0000742)1.89062872
94Abnormality of the diencephalon (HP:0010662)1.88998671
95Intestinal polyp (HP:0005266)1.88831694
96Polymicrogyria (HP:0002126)1.88385244
97Long eyelashes (HP:0000527)1.88322074
98Death in infancy (HP:0001522)1.87996292
99Leiomyosarcoma (HP:0100243)1.87862569
100Uterine leiomyosarcoma (HP:0002891)1.87862569
101Hepatoblastoma (HP:0002884)1.86935630
102Failure to thrive in infancy (HP:0001531)1.86665402
103Abnormality of the metopic suture (HP:0005556)1.86465132
104Deviation of the hallux (HP:0010051)1.86204899
105Biliary tract neoplasm (HP:0100574)1.86167712
106Rhabdomyosarcoma (HP:0002859)1.84929789
107Abnormality of the lower motor neuron (HP:0002366)1.84607189
108Increased density of long bones (HP:0006392)1.84061766
109Postnatal microcephaly (HP:0005484)1.83856318
110Prominent nose (HP:0000448)1.83778050
111Birth length less than 3rd percentile (HP:0003561)1.83365999
112Patellar aplasia (HP:0006443)1.82164039
113Intestinal polyposis (HP:0200008)1.80900606
114Pachygyria (HP:0001302)1.80802832
115Transitional cell carcinoma of the bladder (HP:0006740)1.79230210
116Megalencephaly (HP:0001355)1.78288107
117Amyotrophic lateral sclerosis (HP:0007354)1.78100049
118Neoplasm of the adrenal cortex (HP:0100641)1.78064640
119Megalocornea (HP:0000485)1.78014425
120Flat cornea (HP:0007720)1.77702277
121Broad thumb (HP:0011304)1.77262185
122Prominent metopic ridge (HP:0005487)1.77029024
123Aplasia/Hypoplasia of the patella (HP:0006498)1.76673548
124Supernumerary ribs (HP:0005815)1.75816920
125Partial agenesis of the corpus callosum (HP:0001338)1.75426514
126Preauricular skin tag (HP:0000384)1.75019406
127Bicuspid aortic valve (HP:0001647)1.73460141
128Uterine neoplasm (HP:0010784)1.73456851
129Bladder carcinoma (HP:0002862)1.72931625
130Bladder neoplasm (HP:0009725)1.72931625
131Peripheral hypomyelination (HP:0007182)1.72372298
132Ankle clonus (HP:0011448)1.71782696
133Abnormal mitochondria in muscle tissue (HP:0008316)1.71601862
134Lactic acidosis (HP:0003128)1.71317912
135Broad alveolar ridges (HP:0000187)1.70797658
136Exercise intolerance (HP:0003546)1.70646987
137Cerebral aneurysm (HP:0004944)1.70221468
138Chromsome breakage (HP:0040012)1.69797322
139Combined immunodeficiency (HP:0005387)1.69074344
140Chromosomal breakage induced by crosslinking agents (HP:0003221)1.68859172
141Cerebellar dysplasia (HP:0007033)1.68247375
142Panhypogammaglobulinemia (HP:0003139)1.67549884
143Missing ribs (HP:0000921)1.67267148
144External ophthalmoplegia (HP:0000544)1.66743003
145Vertebral arch anomaly (HP:0008438)1.65492646
146Sloping forehead (HP:0000340)1.64206051
147Abnormality of the intervertebral disk (HP:0005108)1.63919436
148Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.63729754
149Septate vagina (HP:0001153)1.63523887
150High pitched voice (HP:0001620)1.63408853
151Poor coordination (HP:0002370)1.63238450
152Spina bifida occulta (HP:0003298)1.63026638
153Aplasia/Hypoplasia of the sternum (HP:0006714)1.61683254
154Esophageal atresia (HP:0002032)1.61528537
155Annular pancreas (HP:0001734)1.61513548
156Genu recurvatum (HP:0002816)1.61372772
157Increased muscle lipid content (HP:0009058)1.60772474
158Horseshoe kidney (HP:0000085)1.60134558
159Abnormality of the fingertips (HP:0001211)1.59245193
160Neoplasm of the pancreas (HP:0002894)1.58480259
161Cerebral hypomyelination (HP:0006808)1.57040043
162Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.56888197
163Decreased activity of mitochondrial respiratory chain (HP:0008972)1.56888197
164Preaxial hand polydactyly (HP:0001177)1.56672520
165Medial flaring of the eyebrow (HP:0010747)1.56429050
166Broad phalanges of the hand (HP:0009768)1.56235118
167Neonatal respiratory distress (HP:0002643)1.55876244
168Granulocytopenia (HP:0001913)1.55806226
169Cerebellar hypoplasia (HP:0001321)1.55172233
170Cafe-au-lait spot (HP:0000957)1.54448975
171Abnormality of chromosome segregation (HP:0002916)1.54173940
172Supernumerary bones of the axial skeleton (HP:0009144)1.53695595
173Broad distal phalanx of finger (HP:0009836)1.53669454
174Esotropia (HP:0000565)1.53341818
175Aplasia/hypoplasia of the uterus (HP:0008684)1.53237575
176Muscle fiber atrophy (HP:0100295)1.52748371
177Tented upper lip vermilion (HP:0010804)1.49128672
178Type II lissencephaly (HP:0007260)1.49036114
179EMG: myopathic abnormalities (HP:0003458)1.48342493
180Oligodactyly (HP:0012165)1.48266660
181Decreased testicular size (HP:0008734)1.48138183
182Degeneration of anterior horn cells (HP:0002398)1.47993062
183Abnormality of the anterior horn cell (HP:0006802)1.47993062
184Delayed myelination (HP:0012448)1.47572407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.23804897
2MAP3K103.90074653
3TRIB33.28477829
4MAP4K23.16702179
5CDC73.11036382
6PKN22.88615446
7MAP2K72.87620203
8PRPF4B2.80742299
9BUB12.72626352
10CDK192.67212521
11NEK22.57437516
12SIK32.43230907
13CDK122.22593218
14ICK2.16904688
15STK161.95563663
16NEK11.93805051
17BCKDK1.85427478
18PASK1.82007466
19SCYL21.73412331
20KSR11.71807988
21DYRK21.70973761
22TRIM281.70775073
23TAOK21.66629251
24NME21.62275888
25RPS6KB21.60632534
26MAP3K41.56862903
27PTK61.55977689
28WEE11.53801489
29PAK41.50340133
30BCR1.49553391
31TYRO31.48246043
32ALK1.43272630
33EPHA31.42644080
34RPS6KA41.39583695
35CSNK1G21.36995681
36PDGFRA1.36775073
37PIM21.36267421
38LRRK21.33821624
39LATS11.32135860
40PRKD31.31662148
41TESK21.28940243
42CSNK1G11.28667548
43DYRK31.28657091
44CDK41.26148428
45KSR21.25357610
46TTK1.25043382
47MAPK131.23417434
48MAPKAPK31.17322623
49FGFR11.13795110
50CDK61.13124651
51RPS6KA51.11772772
52RAF11.11426575
53MTOR1.11118738
54ATR1.09756055
55STK101.09650769
56TGFBR11.03223946
57GRK61.02826435
58FGFR31.02419205
59DYRK1B1.01339888
60PINK10.98921165
61VRK20.98529493
62MAPK110.95338666
63MAP3K80.94694050
64CDK70.91725078
65TTN0.90348603
66FGFR20.89479658
67PLK10.88421967
68UHMK10.88316173
69PDK20.88207010
70MAP4K10.87928878
71CAMK40.87728105
72MKNK10.87687590
73* CHEK10.84717412
74MELK0.82946521
75MARK30.82893013
76AURKB0.80611237
77CDK20.80370253
78BRSK10.79215860
79PIM10.79159332
80RIPK10.78243058
81CHEK20.78075535
82MARK20.77948052
83SMG10.77422414
84ERN10.77229129
85PNCK0.75416590
86ILK0.74780716
87TAOK10.72677830
88MAP3K90.72662764
89MARK10.71696366
90PAK60.71154361
91CSNK1A1L0.68843385
92CDK80.67156886
93ZAK0.66237613
94OBSCN0.66185370
95IRAK20.66100777
96BRD40.66021172
97LATS20.65385359
98EPHB20.65162127
99PRKD20.64190092
100TSSK60.62946159
101DMPK0.61803626
102MAP3K70.61332656
103SRPK10.61314327
104ACVR1B0.60923478
105TESK10.60838334
106ITK0.59227909
107AURKA0.58523677
108AKT20.58143863
109TLK10.57817166
110ATM0.57223483
111CDK30.56820014
112PLK30.56130246
113FGFR40.56086275
114CDK10.55958175
115HIPK20.54164864
116EPHB10.54033477
117NME10.53931200
118RET0.53472509
119PAK20.52240917
120STK40.52040706
121CSNK1D0.51760389
122ERBB20.51485704
123PDGFRB0.50812386
124SIK20.50231672
125FES0.48770660
126MAPK90.47478494
127MAP2K40.45499736
128CSNK1E0.45350805
129ERBB30.45205654
130PRKDC0.44844075
131IKBKE0.44629875
132CCNB10.44560618
133SIK10.44206687
134CDK140.43381689
135DDR20.43366504
136PRKAA10.43132969
137FLT30.42784024
138CSNK1G30.42720882
139CDK11A0.42162690
140CDK180.41892829
141RPS6KA10.41305089
142STK30.41226389
143PHKG10.40955052
144PHKG20.40955052
145CDK150.39332496
146VRK10.39167245
147DYRK1A0.38461363
148MAP3K50.38373129
149MAPK120.37304752
150PKN10.35357113
151MAPK100.33321515

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.04577098
2Spliceosome_Homo sapiens_hsa030402.69641665
3Sulfur relay system_Homo sapiens_hsa041222.34627703
4RNA polymerase_Homo sapiens_hsa030202.30076966
5Mismatch repair_Homo sapiens_hsa034302.29031269
6Cell cycle_Homo sapiens_hsa041102.17181070
7RNA transport_Homo sapiens_hsa030132.15017879
8mRNA surveillance pathway_Homo sapiens_hsa030152.09905597
9Base excision repair_Homo sapiens_hsa034102.09098290
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96323677
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92510663
12Pyrimidine metabolism_Homo sapiens_hsa002401.92318012
13Chronic myeloid leukemia_Homo sapiens_hsa052201.82969602
14Basal cell carcinoma_Homo sapiens_hsa052171.71596982
15Colorectal cancer_Homo sapiens_hsa052101.69771446
16mTOR signaling pathway_Homo sapiens_hsa041501.62357851
17Biosynthesis of amino acids_Homo sapiens_hsa012301.58271010
18Oocyte meiosis_Homo sapiens_hsa041141.54076553
19Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53310300
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51699628
21Endometrial cancer_Homo sapiens_hsa052131.51347746
22Hippo signaling pathway_Homo sapiens_hsa043901.47267059
23Notch signaling pathway_Homo sapiens_hsa043301.44227193
24MicroRNAs in cancer_Homo sapiens_hsa052061.42196921
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36202621
26Non-small cell lung cancer_Homo sapiens_hsa052231.36138299
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.33966505
28HTLV-I infection_Homo sapiens_hsa051661.32762958
29Hedgehog signaling pathway_Homo sapiens_hsa043401.31832511
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.29552015
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28388580
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28160043
33Glioma_Homo sapiens_hsa052141.25352671
34Basal transcription factors_Homo sapiens_hsa030221.24169800
35Viral carcinogenesis_Homo sapiens_hsa052031.23933787
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.21525213
37Nucleotide excision repair_Homo sapiens_hsa034201.20465187
38T cell receptor signaling pathway_Homo sapiens_hsa046601.20132556
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16962045
40Non-homologous end-joining_Homo sapiens_hsa034501.16899843
41Renal cell carcinoma_Homo sapiens_hsa052111.15846108
42Alcoholism_Homo sapiens_hsa050341.15785578
43p53 signaling pathway_Homo sapiens_hsa041151.14371961
44Small cell lung cancer_Homo sapiens_hsa052221.13737973
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13045960
46VEGF signaling pathway_Homo sapiens_hsa043701.12089137
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.11958591
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10533992
49Dorso-ventral axis formation_Homo sapiens_hsa043201.09570508
50Regulation of autophagy_Homo sapiens_hsa041401.07754630
51Pancreatic cancer_Homo sapiens_hsa052121.06348842
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05529941
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04754045
54Acute myeloid leukemia_Homo sapiens_hsa052211.04608043
55Proteoglycans in cancer_Homo sapiens_hsa052051.04354796
56B cell receptor signaling pathway_Homo sapiens_hsa046621.04266278
57Bladder cancer_Homo sapiens_hsa052191.03672430
58Thyroid cancer_Homo sapiens_hsa052161.03551795
59Viral myocarditis_Homo sapiens_hsa054161.02158574
60Wnt signaling pathway_Homo sapiens_hsa043101.01410352
61Systemic lupus erythematosus_Homo sapiens_hsa053221.01298998
62One carbon pool by folate_Homo sapiens_hsa006700.98588143
63Adherens junction_Homo sapiens_hsa045200.98568699
64Estrogen signaling pathway_Homo sapiens_hsa049150.92933684
65Purine metabolism_Homo sapiens_hsa002300.89699467
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88048092
67Parkinsons disease_Homo sapiens_hsa050120.87680762
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86211187
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.86143952
70Antigen processing and presentation_Homo sapiens_hsa046120.85884872
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85639135
72RNA degradation_Homo sapiens_hsa030180.83599687
73Homologous recombination_Homo sapiens_hsa034400.82655064
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82290608
75Pathways in cancer_Homo sapiens_hsa052000.81722383
76Huntingtons disease_Homo sapiens_hsa050160.81593042
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80006786
78Gap junction_Homo sapiens_hsa045400.79129943
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78818461
80TGF-beta signaling pathway_Homo sapiens_hsa043500.78239221
81Hepatitis B_Homo sapiens_hsa051610.78239118
82Insulin signaling pathway_Homo sapiens_hsa049100.77874808
83Long-term potentiation_Homo sapiens_hsa047200.77639689
84Carbon metabolism_Homo sapiens_hsa012000.77509723
85Lysine degradation_Homo sapiens_hsa003100.77049685
86Epstein-Barr virus infection_Homo sapiens_hsa051690.76081057
87ErbB signaling pathway_Homo sapiens_hsa040120.76074018
88Primary immunodeficiency_Homo sapiens_hsa053400.75899378
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75577852
90Proteasome_Homo sapiens_hsa030500.75349381
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74890606
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74380948
93Prostate cancer_Homo sapiens_hsa052150.72958291
94Folate biosynthesis_Homo sapiens_hsa007900.71707735
95Prolactin signaling pathway_Homo sapiens_hsa049170.71605221
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70644015
97FoxO signaling pathway_Homo sapiens_hsa040680.68448535
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68318498
99Herpes simplex infection_Homo sapiens_hsa051680.67084242
100Focal adhesion_Homo sapiens_hsa045100.65642942
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65535784
102AMPK signaling pathway_Homo sapiens_hsa041520.65096635
103Melanogenesis_Homo sapiens_hsa049160.65091488
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64860228
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.64839591
106Insulin resistance_Homo sapiens_hsa049310.64116022
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63938535
108Ribosome_Homo sapiens_hsa030100.62954053
109Fructose and mannose metabolism_Homo sapiens_hsa000510.62862361
110Circadian rhythm_Homo sapiens_hsa047100.62716537
111Endocytosis_Homo sapiens_hsa041440.62570086
112Selenocompound metabolism_Homo sapiens_hsa004500.62080237
113Tight junction_Homo sapiens_hsa045300.57890727
114Fanconi anemia pathway_Homo sapiens_hsa034600.57866219
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.57056366
116Axon guidance_Homo sapiens_hsa043600.56628666
117Shigellosis_Homo sapiens_hsa051310.56477781
118Rap1 signaling pathway_Homo sapiens_hsa040150.55037868
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54525095
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54470438
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54439075
122Apoptosis_Homo sapiens_hsa042100.54391708
123GnRH signaling pathway_Homo sapiens_hsa049120.53942663
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52939527
125N-Glycan biosynthesis_Homo sapiens_hsa005100.52148107
126HIF-1 signaling pathway_Homo sapiens_hsa040660.51265891
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50517238
128Olfactory transduction_Homo sapiens_hsa047400.50426746
129MAPK signaling pathway_Homo sapiens_hsa040100.50295579
130Platelet activation_Homo sapiens_hsa046110.48908633
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46175576
132Oxidative phosphorylation_Homo sapiens_hsa001900.45427304
133Steroid biosynthesis_Homo sapiens_hsa001000.42761400
134Choline metabolism in cancer_Homo sapiens_hsa052310.39804014
135Fatty acid elongation_Homo sapiens_hsa000620.37316846
136Vibrio cholerae infection_Homo sapiens_hsa051100.36417792
137Legionellosis_Homo sapiens_hsa051340.35878695
138Pyruvate metabolism_Homo sapiens_hsa006200.31757021
139Pentose phosphate pathway_Homo sapiens_hsa000300.31573764
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29609469
141Hepatitis C_Homo sapiens_hsa051600.25419486
142Phototransduction_Homo sapiens_hsa047440.25146237
143Collecting duct acid secretion_Homo sapiens_hsa049660.23380966
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23211517

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