CHTF18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.35218419
2protein localization to kinetochore (GO:0034501)5.18050901
3DNA strand elongation involved in DNA replication (GO:0006271)5.05455219
4DNA replication initiation (GO:0006270)5.00755264
5DNA strand elongation (GO:0022616)4.79617245
6telomere maintenance via semi-conservative replication (GO:0032201)4.69788620
7DNA replication-dependent nucleosome organization (GO:0034723)4.53188350
8DNA replication-dependent nucleosome assembly (GO:0006335)4.53188350
9protein localization to chromosome, centromeric region (GO:0071459)4.43630881
10DNA replication checkpoint (GO:0000076)4.39972746
11mitotic sister chromatid segregation (GO:0000070)4.34286343
12nuclear pore organization (GO:0006999)4.31470794
13mitotic nuclear envelope disassembly (GO:0007077)4.29790815
14mitotic metaphase plate congression (GO:0007080)4.24420409
15DNA topological change (GO:0006265)4.22579671
16telomere maintenance via recombination (GO:0000722)4.15956142
17nucleobase biosynthetic process (GO:0046112)4.15384502
18folic acid-containing compound biosynthetic process (GO:0009396)4.08631858
19mitotic recombination (GO:0006312)4.05625333
20negative regulation of mRNA processing (GO:0050686)4.05165045
21nuclear pore complex assembly (GO:0051292)4.04729219
22formation of translation preinitiation complex (GO:0001731)4.01032230
23nuclear envelope disassembly (GO:0051081)3.98910144
24membrane disassembly (GO:0030397)3.98910144
25sister chromatid segregation (GO:0000819)3.95968213
26IMP biosynthetic process (GO:0006188)3.93189980
27regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.85708849
28regulation of mammary gland epithelial cell proliferation (GO:0033599)3.84540826
29ribosomal small subunit biogenesis (GO:0042274)3.82095079
30chromosome condensation (GO:0030261)3.81349085
31spliceosomal tri-snRNP complex assembly (GO:0000244)3.80483666
32mitotic chromosome condensation (GO:0007076)3.79271598
33negative regulation of mRNA metabolic process (GO:1903312)3.79184184
34proline biosynthetic process (GO:0006561)3.76427816
35telomere maintenance via telomere lengthening (GO:0010833)3.76392827
36purine nucleobase biosynthetic process (GO:0009113)3.74751103
37nucleotide-excision repair, DNA gap filling (GO:0006297)3.74581278
38nucleosome disassembly (GO:0006337)3.72791794
39protein-DNA complex disassembly (GO:0032986)3.72791794
40kinetochore organization (GO:0051383)3.71996684
41DNA duplex unwinding (GO:0032508)3.71990592
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.70745355
43DNA geometric change (GO:0032392)3.70722433
44metaphase plate congression (GO:0051310)3.70717882
45regulation of gene silencing by RNA (GO:0060966)3.68431554
46regulation of posttranscriptional gene silencing (GO:0060147)3.68431554
47regulation of gene silencing by miRNA (GO:0060964)3.68431554
48DNA synthesis involved in DNA repair (GO:0000731)3.63575840
49chromatin remodeling at centromere (GO:0031055)3.60104746
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.58131413
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.58131413
52negative regulation of RNA splicing (GO:0033119)3.56696736
53maturation of SSU-rRNA (GO:0030490)3.54132469
54positive regulation of chromosome segregation (GO:0051984)3.53645589
55peptidyl-arginine omega-N-methylation (GO:0035247)3.52312573
56regulation of spindle organization (GO:0090224)3.52229969
57heterochromatin organization (GO:0070828)3.52202033
58CENP-A containing nucleosome assembly (GO:0034080)3.51292259
59kinetochore assembly (GO:0051382)3.46095398
60attachment of spindle microtubules to kinetochore (GO:0008608)3.45785981
61ribosome biogenesis (GO:0042254)3.45057310
62DNA replication-independent nucleosome assembly (GO:0006336)3.42043849
63DNA replication-independent nucleosome organization (GO:0034724)3.42043849
64DNA deamination (GO:0045006)3.39840404
65IMP metabolic process (GO:0046040)3.36054841
66mitotic sister chromatid cohesion (GO:0007064)3.35525424
67protein complex localization (GO:0031503)3.34796855
68establishment of chromosome localization (GO:0051303)3.34268488
69L-serine metabolic process (GO:0006563)3.30624976
70regulation of translational fidelity (GO:0006450)3.29858575
71ribosome assembly (GO:0042255)3.25714718
72regulation of chromosome segregation (GO:0051983)3.24669268
73negative regulation of chromosome segregation (GO:0051985)3.23259132
74regulation of histone H3-K9 methylation (GO:0051570)3.21278298
75planar cell polarity pathway involved in neural tube closure (GO:0090179)3.20615373
76ribosomal small subunit assembly (GO:0000028)3.20128953
77protein localization to chromosome (GO:0034502)3.19020543
78chromatin assembly or disassembly (GO:0006333)3.18167539
79pore complex assembly (GO:0046931)3.15652457
80DNA packaging (GO:0006323)3.15298603
81ribonucleoprotein complex biogenesis (GO:0022613)3.14536625
82regulation of double-strand break repair via homologous recombination (GO:0010569)3.14183107
83meiotic chromosome segregation (GO:0045132)3.13649972
84establishment of integrated proviral latency (GO:0075713)3.13000143
85apoptotic process involved in morphogenesis (GO:0060561)3.12796618
86activation of Rac GTPase activity (GO:0032863)3.12135961
87regulation of centrosome cycle (GO:0046605)3.11711253
88protein K6-linked ubiquitination (GO:0085020)3.11317621
89spindle checkpoint (GO:0031577)3.11277511
90DNA conformation change (GO:0071103)3.11017425
91negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10790579
92chromatin assembly (GO:0031497)3.10414014
93nuclear envelope organization (GO:0006998)3.10258829
94viral mRNA export from host cell nucleus (GO:0046784)3.10107633
95histone exchange (GO:0043486)3.09764765
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09658348
97negative regulation of sister chromatid segregation (GO:0033046)3.09658348
98negative regulation of mitotic sister chromatid separation (GO:2000816)3.09658348
99negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09658348
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08655265
101regulation of RNA export from nucleus (GO:0046831)3.08418049
102regulation of nuclear cell cycle DNA replication (GO:0033262)3.07299950
103translesion synthesis (GO:0019985)3.06616315
104spindle assembly checkpoint (GO:0071173)3.06228180
105viral transcription (GO:0019083)3.06141795
106regulation of mitotic spindle organization (GO:0060236)3.05696327
107spliceosomal snRNP assembly (GO:0000387)3.04865393
108base-excision repair (GO:0006284)3.03575543
109mitotic spindle assembly checkpoint (GO:0007094)3.02569583
110histone arginine methylation (GO:0034969)3.02068411
111regulation of sister chromatid cohesion (GO:0007063)3.01582548
112regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00889356
113positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00612837
114positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00612837
115positive regulation of mitotic sister chromatid separation (GO:1901970)3.00612837
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99630404
117telomere organization (GO:0032200)2.99465514
118ribosomal large subunit biogenesis (GO:0042273)2.99002341
119telomere maintenance (GO:0000723)2.98569714
120negative regulation of histone methylation (GO:0031061)2.98407801
121chromosome segregation (GO:0007059)2.97711642
122mismatch repair (GO:0006298)2.96452274
123rRNA processing (GO:0006364)2.96107501
124mitotic spindle checkpoint (GO:0071174)2.95451325
125regulation of histone H3-K27 methylation (GO:0061085)2.93986316
126regulation of chromatin binding (GO:0035561)2.93495011
127regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93339786
128regulation of helicase activity (GO:0051095)2.92713301
129peptidyl-arginine methylation (GO:0018216)2.92623258
130peptidyl-arginine N-methylation (GO:0035246)2.92623258
131positive regulation of DNA-dependent DNA replication (GO:2000105)2.92212757
132RNA stabilization (GO:0043489)2.90184933
133mRNA stabilization (GO:0048255)2.90184933
134convergent extension (GO:0060026)2.87539249
135nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86464378
136regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.85992302
137DNA strand renaturation (GO:0000733)2.85055750
138translational termination (GO:0006415)2.84839075
139cellular protein complex localization (GO:0034629)2.79082976
140mitotic G1 DNA damage checkpoint (GO:0031571)2.78832310
141DNA ligation (GO:0006266)2.78484240
142snRNA metabolic process (GO:0016073)2.76615239
143intracellular estrogen receptor signaling pathway (GO:0030520)2.73285191
144positive regulation of cell cycle checkpoint (GO:1901978)2.72675335
145mitotic nuclear envelope reassembly (GO:0007084)2.72347162
146nuclear envelope reassembly (GO:0031468)2.72347162
147folic acid metabolic process (GO:0046655)2.72214803
148peptidyl-lysine dimethylation (GO:0018027)2.72169322
149rRNA transcription (GO:0009303)2.71610198
150V(D)J recombination (GO:0033151)2.69562553
151pentose-phosphate shunt (GO:0006098)2.68391381
152Golgi transport vesicle coating (GO:0048200)2.67135385
153COPI coating of Golgi vesicle (GO:0048205)2.67135385
154protein export from nucleus (GO:0006611)2.67084804
155negative regulation of cell size (GO:0045792)2.64896950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.25183724
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.74222579
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.00566125
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.77408663
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50672226
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23866754
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.01696904
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69610010
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60140918
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39515374
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.35674098
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33211407
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.30877319
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23969364
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19360533
16XRN2_22483619_ChIP-Seq_HELA_Human2.16495405
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13734020
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07709319
19AR_21909140_ChIP-Seq_LNCAP_Human2.06817125
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.03790798
21NANOG_18555785_ChIP-Seq_MESCs_Mouse2.03234297
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01746521
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.01291620
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.00315370
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.96628105
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.94359291
27LXR_22292898_ChIP-Seq_THP-1_Human1.88945595
28MYC_22102868_ChIP-Seq_BL_Human1.87297523
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86128092
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.83973235
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83085295
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81143192
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79669843
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78803104
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78424142
36VDR_23849224_ChIP-Seq_CD4+_Human1.76797662
37ZNF263_19887448_ChIP-Seq_K562_Human1.74195151
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.68196617
39FOXP3_21729870_ChIP-Seq_TREG_Human1.66751619
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66059493
41DCP1A_22483619_ChIP-Seq_HELA_Human1.62747840
42CIITA_25753668_ChIP-Seq_RAJI_Human1.62628084
43RACK7_27058665_Chip-Seq_MCF-7_Human1.60930542
44GABP_19822575_ChIP-Seq_HepG2_Human1.59607646
45TTF2_22483619_ChIP-Seq_HELA_Human1.59078600
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56829293
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.50999498
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.50999498
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.50999498
50KDM5A_27292631_Chip-Seq_BREAST_Human1.45114479
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.44767002
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.42900285
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42853386
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42501427
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42151152
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41741386
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40910361
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40878901
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40108346
60KDM2B_26808549_Chip-Seq_DND41_Human1.39650083
61TCF7_22412390_ChIP-Seq_EML_Mouse1.38987989
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38753015
63* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37913943
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.36636607
65P68_20966046_ChIP-Seq_HELA_Human1.35786477
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34685897
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34592155
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34567035
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33798430
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33498289
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33123697
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32422216
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32268906
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25555143
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25453369
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.24396896
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24159716
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23354025
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.22731907
80VDR_21846776_ChIP-Seq_THP-1_Human1.22350751
81NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21242443
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20723127
83NCOR1_26117541_ChIP-Seq_K562_Human1.20708902
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19275451
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19012023
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17278666
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16237553
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13365305
89ELK1_19687146_ChIP-ChIP_HELA_Human1.12643616
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12089507
91TFEB_21752829_ChIP-Seq_HELA_Human1.11896889
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11594142
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.10449521
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09276112
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08962958
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08651833
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.08588038
98* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06429303
99KDM2B_26808549_Chip-Seq_K562_Human1.06375238
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06163666
101MAF_26560356_Chip-Seq_TH2_Human1.05925532
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05813030
103ERG_21242973_ChIP-ChIP_JURKAT_Human1.05266519
104CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05173484
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04545511
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03037025
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02863553
108UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02488814
109FOXP1_21924763_ChIP-Seq_HESCs_Human1.02320403
110TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02157461
111CREB1_26743006_Chip-Seq_LNCaP_Human1.02107321
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02044897
113ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01469754
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01279252
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01093652
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99296311
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98592664
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.97981542
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97840039
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97155375
121ATF3_27146783_Chip-Seq_COLON_Human0.97086429
122* SMC4_20622854_ChIP-Seq_HELA_Human0.96379058
123MAF_26560356_Chip-Seq_TH1_Human0.95376252
124CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95305598
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94966573
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.94411672
127SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94339780
128UTX_26944678_Chip-Seq_JUKART_Human0.94306581
129OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94235393
130PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93040374
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92754978
132NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92661290
133SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.91847798
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91374446
135ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91254546
136SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89368715
137SRF_21415370_ChIP-Seq_HL-1_Mouse0.88951332
138SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87973617
139BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87545904
140POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85073174
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84236062
142SALL1_21062744_ChIP-ChIP_HESCs_Human0.83925874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.04654399
2MP0003111_abnormal_nucleus_morphology4.78666392
3MP0010094_abnormal_chromosome_stability4.75113228
4MP0004957_abnormal_blastocyst_morpholog4.40662531
5MP0008057_abnormal_DNA_replication4.35174894
6MP0003077_abnormal_cell_cycle4.00767723
7MP0008058_abnormal_DNA_repair3.05112052
8MP0010352_gastrointestinal_tract_polyps2.75327222
9MP0001730_embryonic_growth_arrest2.61629195
10MP0008932_abnormal_embryonic_tissue2.56750494
11MP0008007_abnormal_cellular_replicative2.53905516
12MP0000350_abnormal_cell_proliferation2.48520780
13MP0010307_abnormal_tumor_latency2.28290398
14MP0003123_paternal_imprinting2.20922437
15MP0008877_abnormal_DNA_methylation2.17508339
16MP0004185_abnormal_adipocyte_glucose2.11346781
17MP0003786_premature_aging2.02995534
18MP0002249_abnormal_larynx_morphology2.02810885
19MP0005380_embryogenesis_phenotype2.00874626
20MP0001672_abnormal_embryogenesis/_devel2.00874626
21MP0002877_abnormal_melanocyte_morpholog1.95773193
22MP0000566_synostosis1.95361345
23MP0001697_abnormal_embryo_size1.91607904
24MP0002396_abnormal_hematopoietic_system1.86815605
25MP0002085_abnormal_embryonic_tissue1.85052834
26MP0005076_abnormal_cell_differentiation1.83847749
27MP0003984_embryonic_growth_retardation1.78644287
28MP0002084_abnormal_developmental_patter1.77405946
29MP0002080_prenatal_lethality1.75937925
30MP0002088_abnormal_embryonic_growth/wei1.74719167
31MP0000678_abnormal_parathyroid_gland1.72879127
32MP0004858_abnormal_nervous_system1.72474829
33MP0004197_abnormal_fetal_growth/weight/1.67292234
34MP0002086_abnormal_extraembryonic_tissu1.65989854
35MP0000490_abnormal_crypts_of1.62315028
36MP0010030_abnormal_orbit_morphology1.61856422
37MP0008260_abnormal_autophagy1.53498089
38MP0000313_abnormal_cell_death1.50603128
39MP0010234_abnormal_vibrissa_follicle1.50256885
40MP0001346_abnormal_lacrimal_gland1.49065591
41MP0005451_abnormal_body_composition1.47223549
42MP0002653_abnormal_ependyma_morphology1.45514991
43MP0003890_abnormal_embryonic-extraembry1.43458466
44MP0002019_abnormal_tumor_incidence1.42984086
45MP0004133_heterotaxia1.42327348
46MP0001293_anophthalmia1.40839651
47MP0003705_abnormal_hypodermis_morpholog1.37391813
48MP0003121_genomic_imprinting1.35413663
49MP0003119_abnormal_digestive_system1.34918382
50MP0003806_abnormal_nucleotide_metabolis1.34535807
51MP0003718_maternal_effect1.33554842
52MP0003283_abnormal_digestive_organ1.31870416
53MP0002210_abnormal_sex_determination1.29801685
54MP0005058_abnormal_lysosome_morphology1.27888730
55MP0009278_abnormal_bone_marrow1.22719489
56MP0003567_abnormal_fetal_cardiomyocyte1.22262808
57MP0001145_abnormal_male_reproductive1.19617507
58MP0001545_abnormal_hematopoietic_system1.18632533
59MP0005397_hematopoietic_system_phenotyp1.18632533
60MP0004808_abnormal_hematopoietic_stem1.17710153
61MP0002796_impaired_skin_barrier1.14393393
62MP0000003_abnormal_adipose_tissue1.11112145
63MP0009379_abnormal_foot_pigmentation1.09737609
64MP0000537_abnormal_urethra_morphology1.09512600
65MP0009053_abnormal_anal_canal1.06832172
66MP0003453_abnormal_keratinocyte_physiol1.06388393
67MP0005666_abnormal_adipose_tissue1.03598115
68MP0001929_abnormal_gametogenesis1.03573692
69MP0003942_abnormal_urinary_system1.02017574
70MP0002089_abnormal_postnatal_growth/wei1.00729948
71MP0003315_abnormal_perineum_morphology1.00525672
72MP0000703_abnormal_thymus_morphology0.99432828
73MP0001849_ear_inflammation0.98897961
74MP0000653_abnormal_sex_gland0.93714847
75MP0009333_abnormal_splenocyte_physiolog0.93463855
76MP0002111_abnormal_tail_morphology0.93400352
77MP0003385_abnormal_body_wall0.92303460
78MP0001348_abnormal_lacrimal_gland0.91647406
79MP0000579_abnormal_nail_morphology0.90858024
80MP0003566_abnormal_cell_adhesion0.90773198
81MP0004381_abnormal_hair_follicle0.90089630
82MP0005023_abnormal_wound_healing0.88607212
83MP0003941_abnormal_skin_development0.88419198
84MP0000358_abnormal_cell_content/0.87559361
85MP0005384_cellular_phenotype0.85200939
86MP0004264_abnormal_extraembryonic_tissu0.84036258
87MP0002060_abnormal_skin_morphology0.83505070
88MP0002722_abnormal_immune_system0.83364861
89MP0005621_abnormal_cell_physiology0.82492950
90MP0002160_abnormal_reproductive_system0.81878788
91MP0009672_abnormal_birth_weight0.81733809
92MP0002092_abnormal_eye_morphology0.81151811
93MP0005375_adipose_tissue_phenotype0.81143493
94MP0005171_absent_coat_pigmentation0.80836412
95MP0006292_abnormal_olfactory_placode0.80465748
96MP0001915_intracranial_hemorrhage0.80271845
97MP0009703_decreased_birth_body0.79660116
98MP0002398_abnormal_bone_marrow0.78337444
99MP0002697_abnormal_eye_size0.77775186
100MP0002098_abnormal_vibrissa_morphology0.77722590
101MP0000428_abnormal_craniofacial_morphol0.76866119
102MP0000689_abnormal_spleen_morphology0.75842048
103MP0002116_abnormal_craniofacial_bone0.75459664
104MP0003937_abnormal_limbs/digits/tail_de0.75367022
105MP0001661_extended_life_span0.74764980
106MP0002254_reproductive_system_inflammat0.74724182
107MP0001873_stomach_inflammation0.74617359
108MP0009931_abnormal_skin_appearance0.72886421
109MP0002114_abnormal_axial_skeleton0.72599120
110MP0000858_altered_metastatic_potential0.72390223
111MP0000477_abnormal_intestine_morphology0.69362310
112MP0002163_abnormal_gland_morphology0.69357628
113MP0010630_abnormal_cardiac_muscle0.69298786
114MP0003763_abnormal_thymus_physiology0.68733141
115MP0000049_abnormal_middle_ear0.68080189
116MP0008770_decreased_survivor_rate0.67735307
117MP0001119_abnormal_female_reproductive0.67710428
118MP0000467_abnormal_esophagus_morphology0.67286340
119MP0001286_abnormal_eye_development0.65464925
120MP0004233_abnormal_muscle_weight0.64469880
121MP0008995_early_reproductive_senescence0.64414645
122MP0005501_abnormal_skin_physiology0.63447860
123MP0003115_abnormal_respiratory_system0.63445325
124MP0003861_abnormal_nervous_system0.63066665
125MP0005389_reproductive_system_phenotype0.61907453
126MP0002925_abnormal_cardiovascular_devel0.61028267
127MP0000432_abnormal_head_morphology0.60964592
128MP0005266_abnormal_metabolism0.60568922
129MP0002429_abnormal_blood_cell0.60134761
130MP0003698_abnormal_male_reproductive0.58977490
131MP0000733_abnormal_muscle_development0.57289730
132MP0003935_abnormal_craniofacial_develop0.56494395
133MP0002161_abnormal_fertility/fecundity0.54571633
134MP0003221_abnormal_cardiomyocyte_apopto0.53975042
135MP0002075_abnormal_coat/hair_pigmentati0.53862322
136MP0002132_abnormal_respiratory_system0.53566422

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.43669826
2Birth length less than 3rd percentile (HP:0003561)4.40599658
3Breast hypoplasia (HP:0003187)3.96903374
4Chromsome breakage (HP:0040012)3.86961826
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.86207104
6Selective tooth agenesis (HP:0001592)3.79561517
7Broad distal phalanx of finger (HP:0009836)3.74056426
8Medulloblastoma (HP:0002885)3.67356723
9Hyperacusis (HP:0010780)3.62710321
10Reticulocytopenia (HP:0001896)3.54553659
11Patellar aplasia (HP:0006443)3.36731275
12Colon cancer (HP:0003003)3.21528965
13Absent radius (HP:0003974)3.21215654
14Meckel diverticulum (HP:0002245)3.18110628
15Abnormality of the ileum (HP:0001549)3.13081908
16Aplasia/Hypoplasia of the patella (HP:0006498)3.12063595
17Abnormality of chromosome stability (HP:0003220)3.06178287
18Rhabdomyosarcoma (HP:0002859)3.05263918
19Astrocytoma (HP:0009592)3.05205775
20Abnormality of the astrocytes (HP:0100707)3.05205775
21Carpal bone hypoplasia (HP:0001498)3.03648036
22Ulnar bowing (HP:0003031)3.03001718
23Aplasia/Hypoplasia of the uvula (HP:0010293)3.01066341
24Absent thumb (HP:0009777)3.00675326
25Impulsivity (HP:0100710)3.00553602
26Aplasia involving forearm bones (HP:0009822)2.98767743
27Absent forearm bone (HP:0003953)2.98767743
28Agnosia (HP:0010524)2.94866029
29Abnormality of the labia minora (HP:0012880)2.93244332
30Abnormality of the preputium (HP:0100587)2.93121266
31Oral leukoplakia (HP:0002745)2.90650150
32Abnormality of cells of the erythroid lineage (HP:0012130)2.90301769
33Abnormal number of incisors (HP:0011064)2.88765598
34Abnormality of the anterior horn cell (HP:0006802)2.87784015
35Degeneration of anterior horn cells (HP:0002398)2.87784015
36Abnormal number of erythroid precursors (HP:0012131)2.77822870
37Small intestinal stenosis (HP:0012848)2.76740294
38Duodenal stenosis (HP:0100867)2.76740294
39Glioma (HP:0009733)2.72885470
40Basal cell carcinoma (HP:0002671)2.72793841
41High anterior hairline (HP:0009890)2.67411013
42Neoplasm of striated muscle (HP:0009728)2.63390646
43Aplasia/hypoplasia of the humerus (HP:0006507)2.57066279
44Rough bone trabeculation (HP:0100670)2.56978390
45Neoplasm of the oral cavity (HP:0100649)2.54040163
46Supernumerary spleens (HP:0009799)2.54037601
47Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.49343917
48Myelodysplasia (HP:0002863)2.48815745
49Microvesicular hepatic steatosis (HP:0001414)2.48670553
50Ectopic kidney (HP:0000086)2.46658210
51Long palpebral fissure (HP:0000637)2.42283068
52Neoplasm of the pancreas (HP:0002894)2.41264851
53Proximal placement of thumb (HP:0009623)2.39540040
54Missing ribs (HP:0000921)2.36924745
55Increased nuchal translucency (HP:0010880)2.36443311
56Abnormality of abdominal situs (HP:0011620)2.36199718
57Abdominal situs inversus (HP:0003363)2.36199718
58Insomnia (HP:0100785)2.35874436
59Progressive muscle weakness (HP:0003323)2.35848372
60Duplicated collecting system (HP:0000081)2.35437936
61Trismus (HP:0000211)2.34642206
62Tracheoesophageal fistula (HP:0002575)2.34013105
63Abnormality of the duodenum (HP:0002246)2.33222984
64Cafe-au-lait spot (HP:0000957)2.32822804
65Deviation of the thumb (HP:0009603)2.32367487
66Absent epiphyses (HP:0010577)2.31879044
67Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.31879044
68Reticulocytosis (HP:0001923)2.31651873
69Bone marrow hypocellularity (HP:0005528)2.30243791
70Pointed chin (HP:0000307)2.29482038
71Rib fusion (HP:0000902)2.29048303
72Sloping forehead (HP:0000340)2.28317862
73Short humerus (HP:0005792)2.28127679
74Broad face (HP:0000283)2.26724990
7511 pairs of ribs (HP:0000878)2.25458533
76Atresia of the external auditory canal (HP:0000413)2.23408314
77Disproportionate tall stature (HP:0001519)2.23285097
78Premature graying of hair (HP:0002216)2.21483979
79Premature ovarian failure (HP:0008209)2.20820558
80Turricephaly (HP:0000262)2.20757820
81Abnormality of the calcaneus (HP:0008364)2.19093392
82Abnormality of the carotid arteries (HP:0005344)2.16471128
83Progressive external ophthalmoplegia (HP:0000590)2.14617833
84Urethral obstruction (HP:0000796)2.14111885
85Squamous cell carcinoma (HP:0002860)2.13193053
86Short thumb (HP:0009778)2.12608472
87Abnormal gallbladder physiology (HP:0012438)2.12405948
88Cholecystitis (HP:0001082)2.12405948
89Prominent nose (HP:0000448)2.12322014
90Horseshoe kidney (HP:0000085)2.12101952
91Cerebral hypomyelination (HP:0006808)2.10480552
92Multiple enchondromatosis (HP:0005701)2.10243298
93Abnormality of the fingertips (HP:0001211)2.08457040
94Abnormality of cochlea (HP:0000375)2.06379945
95Triphalangeal thumb (HP:0001199)2.05922454
96Duplication of thumb phalanx (HP:0009942)2.04038466
97Thin ribs (HP:0000883)2.03362403
98Pallor (HP:0000980)2.03162659
99Deep palmar crease (HP:0006191)2.03152343
100Metaphyseal cupping (HP:0003021)2.03026988
101Abnormal lung lobation (HP:0002101)2.02098215
102High pitched voice (HP:0001620)1.99500841
103Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99005688
104Spinal muscular atrophy (HP:0007269)1.98166477
105Abnormality of the thoracic spine (HP:0100711)1.97094867
106Flared metaphyses (HP:0003015)1.95958107
107Flattened epiphyses (HP:0003071)1.95305873
108Abnormality of the renal collecting system (HP:0004742)1.95195771
109Amaurosis fugax (HP:0100576)1.93215460
110Cellular immunodeficiency (HP:0005374)1.92625124
111Abnormality of reticulocytes (HP:0004312)1.92464814
112Facial hemangioma (HP:0000329)1.92003794
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.91981938
114Microretrognathia (HP:0000308)1.91884706
115Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91781010
116Macrocytic anemia (HP:0001972)1.91331975
117Pseudobulbar signs (HP:0002200)1.90558554
118Ragged-red muscle fibers (HP:0003200)1.90475341
119Distal lower limb amyotrophy (HP:0008944)1.90462194
120Abnormality of the umbilical cord (HP:0010881)1.90438497
121Aplastic anemia (HP:0001915)1.90187093
122Atrophy/Degeneration involving motor neurons (HP:0007373)1.87330419
123Overriding aorta (HP:0002623)1.86825232
124Shallow orbits (HP:0000586)1.86533398
125Annular pancreas (HP:0001734)1.86466953
126Biconcave vertebral bodies (HP:0004586)1.86203968
127Adenoma sebaceum (HP:0009720)1.85990716
128Angiofibromas (HP:0010615)1.85990716
129Achilles tendon contracture (HP:0001771)1.83116102
130Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81585418
131Short 4th metacarpal (HP:0010044)1.81585418
132Skull defect (HP:0001362)1.81337751
133Stridor (HP:0010307)1.81144368
134Truncus arteriosus (HP:0001660)1.80354882
135Rectovaginal fistula (HP:0000143)1.79726555
136Rectal fistula (HP:0100590)1.79726555
137Shawl scrotum (HP:0000049)1.78929209
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.77836971
139Nephroblastoma (Wilms tumor) (HP:0002667)1.76539872
140Biliary tract neoplasm (HP:0100574)1.76171712
141Abnormal trabecular bone morphology (HP:0100671)1.75917104
142Septate vagina (HP:0001153)1.75895575
143Patellar dislocation (HP:0002999)1.74998817
144Preauricular skin tag (HP:0000384)1.74914807
145Premature skin wrinkling (HP:0100678)1.73529915
146Poikiloderma (HP:0001029)1.72372180
147Morphological abnormality of the inner ear (HP:0011390)1.71732519
148Long eyelashes (HP:0000527)1.69021044
149Elfin facies (HP:0004428)1.68695289
150Intestinal fistula (HP:0100819)1.67788327
151Renal duplication (HP:0000075)1.64661932
152Broad phalanges of the hand (HP:0009768)1.64076027
153Testicular atrophy (HP:0000029)1.62843697
154Myopathic facies (HP:0002058)1.61579318
155Thoracic kyphosis (HP:0002942)1.61294641
156Upper limb amyotrophy (HP:0009129)1.60788244
157Distal upper limb amyotrophy (HP:0007149)1.60788244
158Trigonocephaly (HP:0000243)1.60029204
159Slender long bone (HP:0003100)1.59965806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.63798578
2CDC74.46462658
3SMG14.45153445
4WEE14.11284912
5NEK23.20080896
6CDK123.18723782
7SIK12.72421580
8NEK12.65012255
9TTK2.62144006
10IRAK32.18569962
11PLK12.16259224
12EPHA22.13372560
13EEF2K2.07665277
14CDK72.06979925
15EIF2AK12.02037066
16SRPK12.00393821
17TESK21.95047111
18RPS6KB21.90476019
19TSSK61.90326105
20VRK21.86720825
21ACVR1B1.83465871
22MAP3K101.80692641
23TLK11.75806469
24MST1R1.74165075
25AURKB1.71581383
26CHEK21.71074913
27* ATR1.66747854
28BRSK21.64439490
29CDK41.60810994
30PASK1.58150704
31PLK41.55777864
32PRPF4B1.55557647
33STK101.54083424
34MAP3K81.44914774
35CHEK11.42102287
36AURKA1.39138358
37DYRK31.36093432
38VRK11.33532575
39STK41.31931812
40PLK31.30751046
41FGFR41.27430779
42PAK41.26202523
43BRSK11.23388503
44SCYL21.21423234
45NME21.19299710
46BRD41.16662945
47RPS6KA41.14866679
48MKNK11.14690633
49PKN21.11267360
50FLT31.05836964
51CDK21.03183133
52PIM11.02989612
53ICK1.01299511
54ATM1.00119506
55ERN10.97169878
56CCNB10.93208932
57ALK0.93089658
58TAF10.91879762
59PTK60.91590596
60EIF2AK30.89369592
61ZAK0.87752226
62MTOR0.82455889
63MKNK20.81992263
64CDK60.81758932
65TYRO30.81656651
66TGFBR10.80504847
67PRKD30.79623579
68IRAK20.78752240
69PAK10.77773185
70MAPKAPK30.74396572
71NME10.73925808
72MAP2K20.73851458
73* CDK10.72996778
74SIK20.72754692
75TESK10.71649379
76MAP4K10.71627700
77MAP3K130.70735302
78AKT30.68899826
79PDGFRA0.68883200
80PRKCI0.67111286
81MELK0.65895381
82RPS6KC10.64644374
83RPS6KL10.64644374
84CSNK2A20.63823117
85GRK60.62711684
86STK30.61549087
87MET0.61073937
88AKT20.60015861
89RPS6KA20.58982613
90MAP3K110.58800342
91CDK90.58317906
92CAMK1D0.57655958
93CSNK2A10.57552328
94LRRK20.56273237
95ARAF0.55702132
96PTK20.55081139
97MAP3K60.54733039
98LATS20.52354684
99STK160.51939459
100RPS6KA50.49103603
101CDK80.47160293
102PNCK0.46106060
103CDK150.45759840
104RPS6KA60.45444019
105BRAF0.43936432
106TAOK20.43291657
107CSNK1E0.42039701
108PRKDC0.41345391
109KDR0.41297830
110STK38L0.40894661
111PIM20.40524804
112CDK180.40021098
113BMX0.39519204
114CLK10.38447824
115PBK0.38321298
116RIPK10.38252228
117ILK0.37718424
118PRKD20.35391318
119CAMK1G0.34428801
120TRIB30.34288028
121CSF1R0.34268509
122IRAK40.33454102
123CSNK1D0.33021465
124TTN0.32802011
125* MAPK140.32260001
126PAK20.31738227
127MAP2K30.29983106
128AKT10.27650746
129MAPK110.27650321
130MAPK10.27410202
131DAPK10.26721692
132RPS6KA10.26138564
133CDK11A0.24618441
134PDK40.24323701
135PDK30.24323701

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.39421017
2Mismatch repair_Homo sapiens_hsa034304.73704074
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.63153122
4Base excision repair_Homo sapiens_hsa034103.35159490
5Spliceosome_Homo sapiens_hsa030403.33909842
6Homologous recombination_Homo sapiens_hsa034403.17880997
7RNA transport_Homo sapiens_hsa030133.17321374
8One carbon pool by folate_Homo sapiens_hsa006703.02979359
9Nucleotide excision repair_Homo sapiens_hsa034202.97613428
10Cell cycle_Homo sapiens_hsa041102.95735801
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.77228261
12Ribosome_Homo sapiens_hsa030102.70296566
13RNA polymerase_Homo sapiens_hsa030202.61085730
14Fanconi anemia pathway_Homo sapiens_hsa034602.46099790
15Proteasome_Homo sapiens_hsa030502.34145804
16Pyrimidine metabolism_Homo sapiens_hsa002402.16532805
17Non-homologous end-joining_Homo sapiens_hsa034502.01172533
18mRNA surveillance pathway_Homo sapiens_hsa030151.93473189
19RNA degradation_Homo sapiens_hsa030181.74444061
20p53 signaling pathway_Homo sapiens_hsa041151.70837671
21Basal transcription factors_Homo sapiens_hsa030221.64716805
22Systemic lupus erythematosus_Homo sapiens_hsa053221.44812986
23Other glycan degradation_Homo sapiens_hsa005111.18170072
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14374504
25Viral carcinogenesis_Homo sapiens_hsa052031.14195165
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11023531
27Epstein-Barr virus infection_Homo sapiens_hsa051691.10165398
28Oocyte meiosis_Homo sapiens_hsa041141.09667286
29Biosynthesis of amino acids_Homo sapiens_hsa012301.08810577
30Purine metabolism_Homo sapiens_hsa002301.07908131
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07091030
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.02580295
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00956545
34VEGF signaling pathway_Homo sapiens_hsa043700.95258270
35Selenocompound metabolism_Homo sapiens_hsa004500.92025992
36HTLV-I infection_Homo sapiens_hsa051660.87250943
37Glioma_Homo sapiens_hsa052140.84275970
38Herpes simplex infection_Homo sapiens_hsa051680.83299170
39Pentose phosphate pathway_Homo sapiens_hsa000300.82528765
40Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78875653
41MicroRNAs in cancer_Homo sapiens_hsa052060.78849505
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.78638487
43Antigen processing and presentation_Homo sapiens_hsa046120.77495940
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75805911
45Folate biosynthesis_Homo sapiens_hsa007900.74867173
46Small cell lung cancer_Homo sapiens_hsa052220.71799701
47AMPK signaling pathway_Homo sapiens_hsa041520.70853398
48Basal cell carcinoma_Homo sapiens_hsa052170.68825225
49Hippo signaling pathway_Homo sapiens_hsa043900.67570356
50Sulfur relay system_Homo sapiens_hsa041220.65606162
51ErbB signaling pathway_Homo sapiens_hsa040120.65354838
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64781551
53Thyroid cancer_Homo sapiens_hsa052160.64625329
54Vitamin B6 metabolism_Homo sapiens_hsa007500.63850248
55Insulin signaling pathway_Homo sapiens_hsa049100.62687188
56Notch signaling pathway_Homo sapiens_hsa043300.62591433
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.60834003
58Fructose and mannose metabolism_Homo sapiens_hsa000510.60312676
59Alcoholism_Homo sapiens_hsa050340.59839879
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58302067
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56691575
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.56026298
63Bladder cancer_Homo sapiens_hsa052190.54601193
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54232628
65Colorectal cancer_Homo sapiens_hsa052100.53799796
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53645178
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53508663
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.53443569
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52663202
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51734005
71Carbon metabolism_Homo sapiens_hsa012000.51616079
72mTOR signaling pathway_Homo sapiens_hsa041500.50488933
73Hedgehog signaling pathway_Homo sapiens_hsa043400.49778748
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49632048
75Apoptosis_Homo sapiens_hsa042100.47745518
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45937318
77TGF-beta signaling pathway_Homo sapiens_hsa043500.45407744
78Melanogenesis_Homo sapiens_hsa049160.44622247
79Chronic myeloid leukemia_Homo sapiens_hsa052200.43841120
80Pyruvate metabolism_Homo sapiens_hsa006200.43294275
81B cell receptor signaling pathway_Homo sapiens_hsa046620.43261734
82Renal cell carcinoma_Homo sapiens_hsa052110.42902053
83Choline metabolism in cancer_Homo sapiens_hsa052310.42784629
84Legionellosis_Homo sapiens_hsa051340.42065785
85Lysine degradation_Homo sapiens_hsa003100.41978712
86Prion diseases_Homo sapiens_hsa050200.41581949
87Inositol phosphate metabolism_Homo sapiens_hsa005620.40222917
88Adherens junction_Homo sapiens_hsa045200.35283511
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34998774
90Primary immunodeficiency_Homo sapiens_hsa053400.34421134
91Glutathione metabolism_Homo sapiens_hsa004800.33724497
92Pathways in cancer_Homo sapiens_hsa052000.33637462
93Glucagon signaling pathway_Homo sapiens_hsa049220.33210348
94Galactose metabolism_Homo sapiens_hsa000520.32997594
95HIF-1 signaling pathway_Homo sapiens_hsa040660.32912258
96Acute myeloid leukemia_Homo sapiens_hsa052210.31595693
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31392758
98Hepatitis B_Homo sapiens_hsa051610.31274812
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31139251
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27408913
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27210881
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26063974
103Shigellosis_Homo sapiens_hsa051310.25584007
104Non-small cell lung cancer_Homo sapiens_hsa052230.23793620
105Tight junction_Homo sapiens_hsa045300.22645635
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21268826
107Prostate cancer_Homo sapiens_hsa052150.18978045
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18491081
109Measles_Homo sapiens_hsa051620.17491266
110N-Glycan biosynthesis_Homo sapiens_hsa005100.17257754
111Wnt signaling pathway_Homo sapiens_hsa043100.15690861
112Viral myocarditis_Homo sapiens_hsa054160.13550877
113Melanoma_Homo sapiens_hsa052180.13255861
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13017518
115Proteoglycans in cancer_Homo sapiens_hsa052050.12963723
116Influenza A_Homo sapiens_hsa051640.12864885
117Pancreatic cancer_Homo sapiens_hsa052120.11909484
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.11695132
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11170480
120Endometrial cancer_Homo sapiens_hsa052130.11169612
121Huntingtons disease_Homo sapiens_hsa050160.10803302
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.08911914
123Renin-angiotensin system_Homo sapiens_hsa046140.08446621

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