CHST5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dermatan sulfate biosynthetic process (GO:0030208)5.26927242
2locomotory exploration behavior (GO:0035641)5.23528308
3behavioral response to nicotine (GO:0035095)5.17849523
4neuron cell-cell adhesion (GO:0007158)5.16952167
5dermatan sulfate metabolic process (GO:0030205)4.92073324
6DNA deamination (GO:0045006)4.83415810
7* sulfation (GO:0051923)4.61905884
8cell proliferation in forebrain (GO:0021846)4.58904799
9water-soluble vitamin biosynthetic process (GO:0042364)4.52958617
10regulation of glomerulus development (GO:0090192)4.41829525
11cellular response to ATP (GO:0071318)4.36606036
12notochord development (GO:0030903)4.33041829
13glycoprotein catabolic process (GO:0006516)4.18040804
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.17716320
15cell aggregation (GO:0098743)4.10803119
16cartilage condensation (GO:0001502)4.10803119
17regulation of DNA endoreduplication (GO:0032875)3.96405787
18limb bud formation (GO:0060174)3.96204414
19tryptophan catabolic process (GO:0006569)3.90487285
20indole-containing compound catabolic process (GO:0042436)3.90487285
21indolalkylamine catabolic process (GO:0046218)3.90487285
22chondroitin sulfate biosynthetic process (GO:0030206)3.86343644
23flavonoid metabolic process (GO:0009812)3.85810719
24proline transport (GO:0015824)3.84009805
25kynurenine metabolic process (GO:0070189)3.82627659
263-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.77809250
27purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.77809250
28positive regulation of cAMP-mediated signaling (GO:0043950)3.73921729
29cytidine metabolic process (GO:0046087)3.72744617
30cytidine catabolic process (GO:0006216)3.72744617
31cytidine deamination (GO:0009972)3.72744617
32positive regulation of neurological system process (GO:0031646)3.71892641
33regulation of cell proliferation involved in kidney development (GO:1901722)3.70052891
34detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.69273162
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60470373
36gamma-aminobutyric acid transport (GO:0015812)3.55920715
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.55384398
38NADH dehydrogenase complex assembly (GO:0010257)3.55384398
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55384398
40indolalkylamine metabolic process (GO:0006586)3.48770558
41negative regulation of transcription regulatory region DNA binding (GO:2000678)3.47918678
42otic vesicle formation (GO:0030916)3.47374708
43folic acid transport (GO:0015884)3.47162281
44DNA damage induced protein phosphorylation (GO:0006975)3.46906874
45oligosaccharide catabolic process (GO:0009313)3.46330939
46protein complex biogenesis (GO:0070271)3.43988305
47detection of mechanical stimulus involved in sensory perception (GO:0050974)3.38921734
48cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.38378770
49regulation of axon regeneration (GO:0048679)3.37969878
50regulation of neuron projection regeneration (GO:0070570)3.37969878
51spinal cord development (GO:0021510)3.34189408
52regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.33197816
53negative regulation of mast cell activation (GO:0033004)3.31755000
54negative regulation of platelet activation (GO:0010544)3.26988947
55outer ear morphogenesis (GO:0042473)3.26873416
56negative regulation of systemic arterial blood pressure (GO:0003085)3.26425492
57chondrocyte development (GO:0002063)3.21640685
58regulation of phospholipid biosynthetic process (GO:0071071)3.21536280
59mitotic metaphase plate congression (GO:0007080)3.21230092
60parturition (GO:0007567)3.19925195
61thalamus development (GO:0021794)3.19641337
62somite development (GO:0061053)3.18468046
63exploration behavior (GO:0035640)3.17035319
64regulation of meiosis I (GO:0060631)3.16956281
65mitochondrial respiratory chain complex assembly (GO:0033108)3.14838961
66tryptophan metabolic process (GO:0006568)3.14353890
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.14334844
68postsynaptic membrane organization (GO:0001941)3.13757704
69regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.13691329
70positive regulation of fatty acid oxidation (GO:0046321)3.13533244
71pharyngeal system development (GO:0060037)3.13284656
72regulation of axon extension involved in axon guidance (GO:0048841)3.11376967
73reflex (GO:0060004)3.11303079
74pyrimidine ribonucleoside catabolic process (GO:0046133)3.10861292
75negative regulation of telomere maintenance (GO:0032205)3.10601710
76regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09865724
77negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.09194480
78embryonic cranial skeleton morphogenesis (GO:0048701)3.09084493
79face development (GO:0060324)3.07568751
80mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07458156
81detection of light stimulus involved in sensory perception (GO:0050962)3.06637229
82detection of light stimulus involved in visual perception (GO:0050908)3.06637229
83regulation of gene silencing by RNA (GO:0060966)3.06353770
84regulation of posttranscriptional gene silencing (GO:0060147)3.06353770
85regulation of gene silencing by miRNA (GO:0060964)3.06353770
86righting reflex (GO:0060013)3.03339560
87response to pheromone (GO:0019236)3.02284342
88energy coupled proton transport, down electrochemical gradient (GO:0015985)2.99787667
89ATP synthesis coupled proton transport (GO:0015986)2.99787667
90chondroitin sulfate catabolic process (GO:0030207)2.99641565
91dorsal/ventral axis specification (GO:0009950)2.99618831
92regulation of transmission of nerve impulse (GO:0051969)2.97178821
93male genitalia development (GO:0030539)2.96969561
94negative regulation of appetite (GO:0032099)2.96783225
95negative regulation of response to food (GO:0032096)2.96783225
96peptidyl-arginine methylation (GO:0018216)2.95579682
97peptidyl-arginine N-methylation (GO:0035246)2.95579682
98metaphase plate congression (GO:0051310)2.92764225
99mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92198430
100ventricular cardiac muscle cell development (GO:0055015)2.91411882
101protein polyglutamylation (GO:0018095)2.91392929
102indole-containing compound metabolic process (GO:0042430)2.90801642
103glycosphingolipid catabolic process (GO:0046479)2.89468822
104cellular anion homeostasis (GO:0030002)2.88399735
105negative regulation of axon extension (GO:0030517)2.87615973
106response to UV-C (GO:0010225)2.86758741
107epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.86634723
108negative regulation by host of viral transcription (GO:0043922)2.86382182
109regulation of glutamate receptor signaling pathway (GO:1900449)2.83725534
110regulation of mesoderm development (GO:2000380)2.83717519
111cell migration in hindbrain (GO:0021535)2.79735929
112cytoplasmic mRNA processing body assembly (GO:0033962)2.79438381
113cartilage development (GO:0051216)2.78547294
114negative regulation of axon extension involved in axon guidance (GO:0048843)2.78511024
115oligodendrocyte differentiation (GO:0048709)2.78288729
116regulation of meiosis (GO:0040020)2.78271952
117microtubule polymerization or depolymerization (GO:0031109)2.77409837
118glial cell migration (GO:0008347)2.77333910
119dentate gyrus development (GO:0021542)2.76932290
120positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.76899609
121regulation of collateral sprouting (GO:0048670)2.74912232
122lung-associated mesenchyme development (GO:0060484)2.74261381
123protein localization to synapse (GO:0035418)2.73841925
124L-fucose catabolic process (GO:0042355)2.72422543
125fucose catabolic process (GO:0019317)2.72422543
126L-fucose metabolic process (GO:0042354)2.72422543
127regulation of exit from mitosis (GO:0007096)2.72053037
128ganglioside metabolic process (GO:0001573)2.69733244
129urogenital system development (GO:0001655)2.69532723
130protein neddylation (GO:0045116)2.69104426
131peptidyl-arginine omega-N-methylation (GO:0035247)2.68915113
132serotonin metabolic process (GO:0042428)2.68317949
133mitotic chromosome condensation (GO:0007076)2.67709210
134axoneme assembly (GO:0035082)2.67396468
135cellular biogenic amine catabolic process (GO:0042402)2.66744869
136amine catabolic process (GO:0009310)2.66744869
137cellular response to exogenous dsRNA (GO:0071360)2.66608923
138paraxial mesoderm development (GO:0048339)2.66585616
139neuronal action potential (GO:0019228)2.66264698
140regulation of axon guidance (GO:1902667)2.65803941
141signal transduction involved in regulation of gene expression (GO:0023019)2.64737325
142inner ear morphogenesis (GO:0042472)2.64185141
143photoreceptor cell development (GO:0042461)2.64097483
144estrogen metabolic process (GO:0008210)2.63536421
145phosphorelay signal transduction system (GO:0000160)2.62495461
146chondroitin sulfate metabolic process (GO:0030204)2.62008884
147transmission of nerve impulse (GO:0019226)2.61535620
148histone arginine methylation (GO:0034969)2.61493455
149regulation of action potential (GO:0098900)2.61255102
150positive regulation of metanephros development (GO:0072216)2.60521998
151primary amino compound metabolic process (GO:1901160)2.59568243
152purine nucleotide salvage (GO:0032261)2.59500587
153positive regulation of fatty acid transport (GO:2000193)2.57467884
154piRNA metabolic process (GO:0034587)2.57123687
155negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.56508337
156positive regulation of potassium ion transmembrane transport (GO:1901381)2.55872921
157kidney morphogenesis (GO:0060993)2.55865929
158long-term synaptic potentiation (GO:0060291)2.55676116
159regulation of rhodopsin mediated signaling pathway (GO:0022400)2.55544088
160detection of mechanical stimulus (GO:0050982)2.55231901
161generation of neurons (GO:0048699)2.54500477
162innervation (GO:0060384)2.53724801
163positive regulation of cardiac muscle cell differentiation (GO:2000727)2.52272240
164glycolipid catabolic process (GO:0019377)2.51643322
165C4-dicarboxylate transport (GO:0015740)2.51355410
166vitamin biosynthetic process (GO:0009110)2.51017710
167embryonic skeletal joint morphogenesis (GO:0060272)2.50505625
168positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.49537357
169establishment of chromosome localization (GO:0051303)2.48484773
170enteric nervous system development (GO:0048484)2.48269092
171eye photoreceptor cell development (GO:0042462)2.47572721
172DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.47487391
173protein K6-linked ubiquitination (GO:0085020)2.47360100
174negative regulation of synaptic transmission, GABAergic (GO:0032229)2.47356273
175GPI anchor metabolic process (GO:0006505)2.47187926
176rhodopsin mediated signaling pathway (GO:0016056)2.46725962
177negative regulation of homotypic cell-cell adhesion (GO:0034111)2.45541136
178positive regulation of catenin import into nucleus (GO:0035413)2.45413171
179positive regulation of axon extension (GO:0045773)2.45002060
180cornea development in camera-type eye (GO:0061303)2.43778979
181negative regulation of sodium ion transport (GO:0010766)2.43773045
182positive regulation of DNA-dependent DNA replication (GO:2000105)2.43739497
183spinal cord motor neuron differentiation (GO:0021522)2.43451847
184female gonad development (GO:0008585)2.43363276
185electron transport chain (GO:0022900)2.43062735
186protein K11-linked deubiquitination (GO:0035871)2.42852000
187regulation of axon extension (GO:0030516)2.42074531
188regulation of transcription regulatory region DNA binding (GO:2000677)2.41513159
189amino acid import (GO:0043090)2.41263309
190cranial nerve morphogenesis (GO:0021602)2.40047935
191positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.39729552
192positive regulation of chondrocyte differentiation (GO:0032332)2.39148851
193histone H2A acetylation (GO:0043968)2.38577375
194positive regulation of extracellular matrix organization (GO:1903055)2.37934587
195regulation of extent of cell growth (GO:0061387)2.37929744
196ionotropic glutamate receptor signaling pathway (GO:0035235)2.37016172
197regulation of secondary heart field cardioblast proliferation (GO:0003266)2.35404439
198regulation of cardioblast proliferation (GO:0003264)2.35404439

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.85841431
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.57321753
3AR_21572438_ChIP-Seq_LNCaP_Human2.82587052
4EZH2_22144423_ChIP-Seq_EOC_Human2.74218807
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.72438416
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.57255058
7VDR_22108803_ChIP-Seq_LS180_Human2.51872998
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.43882783
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43838424
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36397308
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30908917
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.28533309
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25949323
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25949323
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24779717
16* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20878691
17IGF1R_20145208_ChIP-Seq_DFB_Human2.15300207
18* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12130078
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09605961
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03307307
21GBX2_23144817_ChIP-Seq_PC3_Human2.00686617
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99290169
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98217478
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.89665006
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87640736
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86262062
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86041996
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81235146
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.81143500
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80336724
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.80193674
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.78444306
33ZNF274_21170338_ChIP-Seq_K562_Hela1.78362051
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.76594913
35ER_23166858_ChIP-Seq_MCF-7_Human1.76215919
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.75438654
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71883212
38RNF2_27304074_Chip-Seq_NSC_Mouse1.68290899
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.67257484
40* RING1B_27294783_Chip-Seq_ESCs_Mouse1.67238571
41* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63873436
42BCAT_22108803_ChIP-Seq_LS180_Human1.61335897
43* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60855395
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.58727890
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57203817
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54870668
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54107541
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52410251
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51644495
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51141809
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50377487
52CBP_20019798_ChIP-Seq_JUKART_Human1.49433465
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49433465
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45187272
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.44387944
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42899325
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.42140684
58STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.40951759
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40130407
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39579083
61* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39254283
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39171714
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38805750
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38715660
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.38557156
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38178900
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.36816752
68MYC_18940864_ChIP-ChIP_HL60_Human1.34813650
69IRF1_19129219_ChIP-ChIP_H3396_Human1.34712625
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33794374
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32413286
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32357691
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32357691
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.32308003
75FOXM1_23109430_ChIP-Seq_U2OS_Human1.31872435
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.31680180
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31656607
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28694259
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27834506
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.26891338
81SMAD4_21799915_ChIP-Seq_A2780_Human1.26479223
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25240441
83AR_25329375_ChIP-Seq_VCAP_Human1.25048319
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.24607789
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23296831
86TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23043643
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22339249
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.21834944
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21834944
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21471963
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21358085
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19866668
93TCF4_23295773_ChIP-Seq_U87_Human1.19805919
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19771896
95NANOG_19829295_ChIP-Seq_ESCs_Human1.19600981
96SOX2_19829295_ChIP-Seq_ESCs_Human1.19600981
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.19357719
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19351476
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.18819816
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18373330
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18025182
102JUN_21703547_ChIP-Seq_K562_Human1.17788935
103EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16122457
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16109556
105TCF4_22108803_ChIP-Seq_LS180_Human1.15670639
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15604635
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15326677
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14810954
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.14575307
110E2F7_22180533_ChIP-Seq_HELA_Human1.14048252
111TAF15_26573619_Chip-Seq_HEK293_Human1.13878248
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.13841816
113TP53_22573176_ChIP-Seq_HFKS_Human1.13001964
114EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12937149
115SMAD3_21741376_ChIP-Seq_ESCs_Human1.10891836
116REST_21632747_ChIP-Seq_MESCs_Mouse1.10319566
117NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09423956
118NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07336113
119SOX2_16153702_ChIP-ChIP_HESCs_Human1.06403411
120* NCOR_22424771_ChIP-Seq_293T_Human1.06077049
121AR_21909140_ChIP-Seq_LNCAP_Human1.05948756
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05908012
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05190985
124EWS_26573619_Chip-Seq_HEK293_Human1.04130184
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.03311513
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03030738
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02653501
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.02386553
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02180187
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.01490624
131GATA3_21878914_ChIP-Seq_MCF-7_Human1.01485494
132P53_22387025_ChIP-Seq_ESCs_Mouse1.01394099
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00428683
134TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00174453
135KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00057025
136CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99992446
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99512291
138TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99414074
139FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99373855
140TP53_20018659_ChIP-ChIP_R1E_Mouse0.97613292
141SMAD3_21741376_ChIP-Seq_EPCs_Human0.97315462
142ESR1_21235772_ChIP-Seq_MCF-7_Human0.95944600
143P300_19829295_ChIP-Seq_ESCs_Human0.95838185
144TET1_21490601_ChIP-Seq_MESCs_Mouse0.95109686
145TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94701843
146PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.94415439
147POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93821781
148POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93269072
149FUS_26573619_Chip-Seq_HEK293_Human0.92978813
150CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92669888
151AHR_22903824_ChIP-Seq_MCF-7_Human0.92265601
152STAT3_23295773_ChIP-Seq_U87_Human0.91671880
153P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91128659
154* SOX2_21211035_ChIP-Seq_LN229_Gbm0.90686433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.83433151
2MP0005423_abnormal_somatic_nervous3.13327581
3MP0006292_abnormal_olfactory_placode3.07664611
4MP0009250_abnormal_appendicular_skeleto2.90684642
5MP0005645_abnormal_hypothalamus_physiol2.80425037
6MP0005646_abnormal_pituitary_gland2.65972498
7MP0008872_abnormal_physiological_respon2.43045028
8MP0003195_calcinosis2.38740743
9MP0003879_abnormal_hair_cell2.35982561
10MP0002160_abnormal_reproductive_system2.32896136
11MP0004145_abnormal_muscle_electrophysio2.27361199
12MP0010030_abnormal_orbit_morphology2.26698584
13MP0005551_abnormal_eye_electrophysiolog2.18927752
14MP0002138_abnormal_hepatobiliary_system2.18050306
15MP0003880_abnormal_central_pattern2.15730513
16MP0002735_abnormal_chemical_nociception2.10988718
17MP0006072_abnormal_retinal_apoptosis2.09354079
18MP0002102_abnormal_ear_morphology2.05387051
19MP0000566_synostosis2.03413363
20MP0004134_abnormal_chest_morphology2.02833084
21MP0002184_abnormal_innervation2.01779467
22MP0002876_abnormal_thyroid_physiology2.00556869
23MP0006276_abnormal_autonomic_nervous2.00390180
24MP0005389_reproductive_system_phenotype1.98304868
25MP0002837_dystrophic_cardiac_calcinosis1.95670681
26MP0002233_abnormal_nose_morphology1.88778924
27MP0003646_muscle_fatigue1.88318752
28MP0001299_abnormal_eye_distance/1.88271189
29MP0002653_abnormal_ependyma_morphology1.87977020
30MP0001485_abnormal_pinna_reflex1.86627872
31MP0001968_abnormal_touch/_nociception1.79773187
32MP0003123_paternal_imprinting1.79049864
33MP0000534_abnormal_ureter_morphology1.76386332
34MP0003755_abnormal_palate_morphology1.72857176
35MP0009745_abnormal_behavioral_response1.70845933
36MP0002638_abnormal_pupillary_reflex1.66636274
37MP0003011_delayed_dark_adaptation1.66531565
38MP0000049_abnormal_middle_ear1.65170638
39MP0009384_cardiac_valve_regurgitation1.65023760
40MP0000778_abnormal_nervous_system1.63427734
41MP0000537_abnormal_urethra_morphology1.63163210
42MP0005671_abnormal_response_to1.62273189
43MP0000631_abnormal_neuroendocrine_gland1.61715915
44MP0000762_abnormal_tongue_morphology1.59937781
45MP0001963_abnormal_hearing_physiology1.58522139
46MP0002734_abnormal_mechanical_nocicepti1.57793588
47MP0008877_abnormal_DNA_methylation1.57515331
48MP0008875_abnormal_xenobiotic_pharmacok1.55495702
49MP0008932_abnormal_embryonic_tissue1.54538210
50MP0002282_abnormal_trachea_morphology1.52149395
51MP0004858_abnormal_nervous_system1.51739539
52MP0000163_abnormal_cartilage_morphology1.51708894
53MP0009046_muscle_twitch1.51325814
54MP0001440_abnormal_grooming_behavior1.49967273
55MP0001502_abnormal_circadian_rhythm1.48022814
56MP0005253_abnormal_eye_physiology1.43805699
57MP0002249_abnormal_larynx_morphology1.42428323
58MP0004133_heterotaxia1.39179546
59MP0002277_abnormal_respiratory_mucosa1.38490964
60MP0003122_maternal_imprinting1.38462784
61MP0002064_seizures1.35817309
62MP0003937_abnormal_limbs/digits/tail_de1.35277402
63MP0002733_abnormal_thermal_nociception1.34354251
64MP0000569_abnormal_digit_pigmentation1.33149206
65MP0000026_abnormal_inner_ear1.31558893
66MP0001919_abnormal_reproductive_system1.31452207
67MP0003121_genomic_imprinting1.31199081
68MP0002116_abnormal_craniofacial_bone1.31180939
69MP0003635_abnormal_synaptic_transmissio1.24375624
70MP0002736_abnormal_nociception_after1.24162320
71MP0001270_distended_abdomen1.23991353
72MP0003385_abnormal_body_wall1.23972476
73MP0004859_abnormal_synaptic_plasticity1.21828460
74MP0000462_abnormal_digestive_system1.20649804
75MP0001486_abnormal_startle_reflex1.20545206
76MP0002063_abnormal_learning/memory/cond1.19103654
77MP0002139_abnormal_hepatobiliary_system1.16741300
78MP0003878_abnormal_ear_physiology1.16365880
79MP0005377_hearing/vestibular/ear_phenot1.16365880
80MP0008789_abnormal_olfactory_epithelium1.16184290
81MP0000428_abnormal_craniofacial_morphol1.15938250
82MP0004270_analgesia1.15726867
83MP0005084_abnormal_gallbladder_morpholo1.15047938
84MP0004742_abnormal_vestibular_system1.14878994
85MP0001905_abnormal_dopamine_level1.14809840
86MP0005360_urolithiasis1.14336816
87MP0003638_abnormal_response/metabolism_1.12339362
88MP0005410_abnormal_fertilization1.12170215
89MP0001986_abnormal_taste_sensitivity1.11525679
90MP0001529_abnormal_vocalization1.11308250
91MP0003787_abnormal_imprinting1.10943840
92MP0000516_abnormal_urinary_system1.10634597
93MP0005367_renal/urinary_system_phenotyp1.10634597
94MP0005379_endocrine/exocrine_gland_phen1.10449030
95MP0002272_abnormal_nervous_system1.10338881
96MP0003136_yellow_coat_color1.09854381
97MP0002067_abnormal_sensory_capabilities1.09749363
98MP0004130_abnormal_muscle_cell1.04648164
99MP0002572_abnormal_emotion/affect_behav1.04324829
100MP0004019_abnormal_vitamin_homeostasis1.03421025
101MP0000432_abnormal_head_morphology1.03202466
102MP0003861_abnormal_nervous_system1.03153047
103MP0000467_abnormal_esophagus_morphology1.02830539
104MP0003718_maternal_effect1.01455005
105MP0005508_abnormal_skeleton_morphology1.00963007
106MP0000230_abnormal_systemic_arterial1.00606001
107MP0001970_abnormal_pain_threshold1.00521976
108MP0002089_abnormal_postnatal_growth/wei1.00227809
109MP0004885_abnormal_endolymph1.00168543
110MP0003938_abnormal_ear_development0.99708611
111MP0002928_abnormal_bile_duct0.98860135
112MP0000955_abnormal_spinal_cord0.98128009
113MP0000733_abnormal_muscle_development0.97891076
114MP0009379_abnormal_foot_pigmentation0.97656214
115MP0000613_abnormal_salivary_gland0.97578623
116MP0000383_abnormal_hair_follicle0.97451984
117MP0003942_abnormal_urinary_system0.96688613
118MP0005171_absent_coat_pigmentation0.96202198
119MP0009697_abnormal_copulation0.95746050
120MP0002938_white_spotting0.94255265
121MP0003283_abnormal_digestive_organ0.93822853
122MP0002115_abnormal_skeleton_extremities0.93537193
123MP0005085_abnormal_gallbladder_physiolo0.92584953
124MP0001501_abnormal_sleep_pattern0.92427704
125MP0005195_abnormal_posterior_eye0.91729433
126MP0002882_abnormal_neuron_morphology0.91023675
127MP0003091_abnormal_cell_migration0.90855271
128MP0002113_abnormal_skeleton_development0.89823254
129MP0003252_abnormal_bile_duct0.89547793
130MP0002114_abnormal_axial_skeleton0.89453412
131MP0001765_abnormal_ion_homeostasis0.88681126
132MP0004215_abnormal_myocardial_fiber0.87518494
133MP0003935_abnormal_craniofacial_develop0.87286864
134MP0005174_abnormal_tail_pigmentation0.85830391
135MP0002210_abnormal_sex_determination0.84692367
136MP0002752_abnormal_somatic_nervous0.84121423
137MP0003119_abnormal_digestive_system0.83985260
138MP0000372_irregular_coat_pigmentation0.82499246
139MP0003699_abnormal_female_reproductive0.82368854
140MP0010386_abnormal_urinary_bladder0.81829128
141MP0002109_abnormal_limb_morphology0.80666685
142MP0005448_abnormal_energy_balance0.79888433
143MP0002152_abnormal_brain_morphology0.79589140
144MP0002557_abnormal_social/conspecific_i0.79382831
145MP0000678_abnormal_parathyroid_gland0.79248252
146MP0002751_abnormal_autonomic_nervous0.78829217
147MP0004147_increased_porphyrin_level0.76274774
148MP0005636_abnormal_mineral_homeostasis0.75161343
149MP0003315_abnormal_perineum_morphology0.75102990
150MP0001764_abnormal_homeostasis0.74256110
151MP0003077_abnormal_cell_cycle0.74005461
152MP0004142_abnormal_muscle_tone0.73660502
153MP0003567_abnormal_fetal_cardiomyocyte0.73047188
154MP0004924_abnormal_behavior0.72145916
155MP0005386_behavior/neurological_phenoty0.72145916
156MP0002163_abnormal_gland_morphology0.69117550
157MP0010094_abnormal_chromosome_stability0.69050792
158MP0001943_abnormal_respiration0.68265145

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)6.16251722
2Epiphyseal dysplasia (HP:0002656)5.69053240
3Metaphyseal cupping (HP:0003021)5.52072846
4Vitreoretinal degeneration (HP:0000655)5.15210597
5Pancreatic cysts (HP:0001737)4.31747588
6Pendular nystagmus (HP:0012043)4.27171772
7Metaphyseal dysplasia (HP:0100255)4.20355578
8Mild short stature (HP:0003502)4.19507346
9Genu varum (HP:0002970)4.07459948
10Pancreatic fibrosis (HP:0100732)4.02654017
11True hermaphroditism (HP:0010459)3.98358195
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.98134164
13Delayed epiphyseal ossification (HP:0002663)3.97356776
14Flat capital femoral epiphysis (HP:0003370)3.96902680
15Small epiphyses (HP:0010585)3.85437113
16Irregular vertebral endplates (HP:0003301)3.75662163
17Abolished electroretinogram (ERG) (HP:0000550)3.75228679
18Hypoplastic ischia (HP:0003175)3.65852946
19Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.65050085
20Abnormality of the vertebral endplates (HP:0005106)3.63017458
21Abnormality of femoral epiphyses (HP:0006499)3.58341036
22Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.58341036
23Abnormal tarsal ossification (HP:0008369)3.56738030
24Abnormality of the epiphysis of the femoral head (HP:0010574)3.51508997
25Abnormality of the femoral head (HP:0003368)3.46893629
26Congenital stationary night blindness (HP:0007642)3.43401150
27Hypoplastic pelvis (HP:0008839)3.38341380
28Cupped ribs (HP:0000887)3.36870201
29Absent epiphyses (HP:0010577)3.35948616
30Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.35948616
31Abnormality of the ischium (HP:0003174)3.33489953
32Abnormal rod and cone electroretinograms (HP:0008323)3.23888381
33Genetic anticipation (HP:0003743)3.20404034
34Decreased central vision (HP:0007663)3.15504133
35Molar tooth sign on MRI (HP:0002419)3.07819546
36Abnormality of midbrain morphology (HP:0002418)3.07819546
37Conjunctival hamartoma (HP:0100780)3.05973248
38Hip contracture (HP:0003273)3.05728903
39Methylmalonic acidemia (HP:0002912)3.03404724
40Enlarged epiphyses (HP:0010580)3.01345318
41Flat acetabular roof (HP:0003180)3.00895007
42Furrowed tongue (HP:0000221)3.00201327
43Limited hip movement (HP:0008800)2.99693218
44Congenital, generalized hypertrichosis (HP:0004540)2.96411740
45Progressive cerebellar ataxia (HP:0002073)2.95345547
46Asplenia (HP:0001746)2.91877250
47Nephronophthisis (HP:0000090)2.85383023
48Keratoconus (HP:0000563)2.84196318
49Increased corneal curvature (HP:0100692)2.84196318
50Aplasia/Hypoplasia of the spleen (HP:0010451)2.83167168
51Abnormality of the proximal phalanges of the hand (HP:0009834)2.80921637
52Confusion (HP:0001289)2.76264516
53Carpal bone hypoplasia (HP:0001498)2.74876788
54Severe visual impairment (HP:0001141)2.69570584
55Flattened epiphyses (HP:0003071)2.68982947
56Cystic liver disease (HP:0006706)2.67852800
57Congenital sensorineural hearing impairment (HP:0008527)2.63587104
58Attenuation of retinal blood vessels (HP:0007843)2.62080922
59Abnormality of the labia minora (HP:0012880)2.61874457
60Methylmalonic aciduria (HP:0012120)2.61222699
613-Methylglutaconic aciduria (HP:0003535)2.61179963
62Fetal akinesia sequence (HP:0001989)2.58326825
63Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.55628700
64Arthropathy (HP:0003040)2.49645881
65Neonatal short-limb short stature (HP:0008921)2.48509788
66Barrel-shaped chest (HP:0001552)2.48121323
67Short femoral neck (HP:0100864)2.46447646
68Broad phalanx (HP:0006009)2.43014521
69Hypoplasia of the odontoid process (HP:0003311)2.40789823
70Abnormality of the phalanges of the 2nd finger (HP:0009541)2.40574399
71Abnormality of the renal medulla (HP:0100957)2.40022356
72Metaphyseal irregularity (HP:0003025)2.39155317
73Abnormality of the pubic bones (HP:0003172)2.38934851
74Abnormality of the renal cortex (HP:0011035)2.37091554
75Hypoplasia of the uterus (HP:0000013)2.35048475
76Mitochondrial inheritance (HP:0001427)2.34702425
77Coxa vara (HP:0002812)2.32691215
78Abnormal foot bone ossification (HP:0010675)2.32676104
79Male pseudohermaphroditism (HP:0000037)2.31983709
80Chorioretinal atrophy (HP:0000533)2.31626969
81Glossoptosis (HP:0000162)2.30553395
82Osteoarthritis (HP:0002758)2.30523808
83Stillbirth (HP:0003826)2.27637662
84Gaze-evoked nystagmus (HP:0000640)2.27158850
85Hamartoma of the eye (HP:0010568)2.25645849
86Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.25454606
87Acute necrotizing encephalopathy (HP:0006965)2.25350097
88Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24121607
89Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.23836279
90Agitation (HP:0000713)2.21326776
91Broad long bones (HP:0005622)2.19771177
92Sclerocornea (HP:0000647)2.19371493
93Aplasia/hypoplasia of the uterus (HP:0008684)2.19037545
94Lip pit (HP:0100267)2.18469406
95Optic nerve hypoplasia (HP:0000609)2.15808165
96Mixed hearing impairment (HP:0000410)2.14186622
97Broad finger (HP:0001500)2.13659234
98Disproportionate short-trunk short stature (HP:0003521)2.13003448
99Hypoplastic iliac wings (HP:0002866)2.11546079
100Short middle phalanx of finger (HP:0005819)2.11031704
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09466225
102Abnormality of DNA repair (HP:0003254)2.09229568
103Hepatocellular necrosis (HP:0001404)2.08485939
104Short hallux (HP:0010109)2.07753266
105Aplasia/Hypoplasia of the tongue (HP:0010295)2.07588875
106Decreased circulating renin level (HP:0003351)2.07472527
107Increased CSF lactate (HP:0002490)2.06395569
108Broad phalanges of the hand (HP:0009768)2.06175007
109Mesomelia (HP:0003027)2.05498059
110IgG deficiency (HP:0004315)2.05459811
111Goiter (HP:0000853)2.04878141
112Waddling gait (HP:0002515)2.03520517
113Small hand (HP:0200055)2.03084302
114Urethral obstruction (HP:0000796)2.02819502
115Abnormality of the vitamin B12 metabolism (HP:0004341)2.01556647
116Anomalous pulmonary venous return (HP:0010772)2.01086428
117Abnormality of vitamin B metabolism (HP:0004340)2.00815883
118Porencephaly (HP:0002132)1.99971347
119Short tibia (HP:0005736)1.99877310
120Septo-optic dysplasia (HP:0100842)1.99610870
121Abnormality of the odontoid process (HP:0003310)1.99090938
122Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.98963550
123Progressive macrocephaly (HP:0004481)1.98277955
124Sex reversal (HP:0012245)1.97217871
125Abnormal sex determination (HP:0012244)1.97217871
126Anencephaly (HP:0002323)1.96528347
127Symphalangism affecting the phalanges of the hand (HP:0009773)1.95536706
128Hemiplegia (HP:0002301)1.95432941
129Oral leukoplakia (HP:0002745)1.94819206
130Chronic hepatic failure (HP:0100626)1.94599882
131Abnormal mitochondria in muscle tissue (HP:0008316)1.93482669
132Abnormality of carpal bone ossification (HP:0006257)1.93103577
133Aplasia/Hypoplasia of the hallux (HP:0008362)1.93070219
134Spinal cord compression (HP:0002176)1.90892527
135Acute encephalopathy (HP:0006846)1.88888888
136Vertebral clefting (HP:0008428)1.87202411
137Abnormality of the renal collecting system (HP:0004742)1.87164928
138Broad thumb (HP:0011304)1.85112443
139Fibular hypoplasia (HP:0003038)1.84433111
140Aplasia/hypoplasia of the femur (HP:0005613)1.84142749
141Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.83502235
142Type II lissencephaly (HP:0007260)1.80256602
143Absent/shortened dynein arms (HP:0200106)1.79149533
144Dynein arm defect of respiratory motile cilia (HP:0012255)1.79149533
145Abnormal auditory evoked potentials (HP:0006958)1.78856778
146Abnormal number of erythroid precursors (HP:0012131)1.78764960
147Bony spicule pigmentary retinopathy (HP:0007737)1.78230790
148Abnormality of the pulmonary veins (HP:0011718)1.77873543
149Bone cyst (HP:0012062)1.76765490
150Hepatic necrosis (HP:0002605)1.76577970
151Hyperventilation (HP:0002883)1.76488090
152Congenital hepatic fibrosis (HP:0002612)1.76434172
153Morphological abnormality of the middle ear (HP:0008609)1.76420553
154Abnormal vertebral ossification (HP:0100569)1.75857396
155Hemiparesis (HP:0001269)1.74389836
156Hypoplastic ilia (HP:0000946)1.74336202
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.73808404
158Thyroiditis (HP:0100646)1.73759174
159Renal cortical cysts (HP:0000803)1.73744398
160Tubular atrophy (HP:0000092)1.73572229
161Abnormality of the nasal septum (HP:0000419)1.73556211
162Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.72679972
163Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.71601731
164Absent thumb (HP:0009777)1.71515616
165Platyspondyly (HP:0000926)1.70946497
166Meningioma (HP:0002858)1.70568962
167Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70257660
168Broad-based gait (HP:0002136)1.68814820
169Abnormality of incisor morphology (HP:0011063)1.67969802
170Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67819090
171Abnormality of the middle phalanges of the hand (HP:0009833)1.67278851
172Severe Myopia (HP:0011003)1.66931205
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.66358707
174Long nose (HP:0003189)1.63449882
175Aplasia/Hypoplasia of the fibula (HP:0006492)1.61707811
176Down-sloping shoulders (HP:0200021)1.61694164
177Flared metaphyses (HP:0003015)1.61630730
178Neoplasm of the peripheral nervous system (HP:0100007)1.61447505
179Abnormality of the 2nd finger (HP:0004100)1.60600543
180Abnormality of the middle phalanges of the toes (HP:0010183)1.60195093
181Synostosis of carpal bones (HP:0005048)1.60108166
182Aplasia/Hypoplasia of the patella (HP:0006498)1.59934970
183Abnormal ossification of hand bones (HP:0005921)1.59338610
184Peripheral hypomyelination (HP:0007182)1.59000377
185Abnormality of the phalanges of the 5th finger (HP:0004213)1.58122735
186Neoplasm of the oral cavity (HP:0100649)1.57597276
187Hip dysplasia (HP:0001385)1.57242754
188Mutism (HP:0002300)1.56369697
189Morphological abnormality of the inner ear (HP:0011390)1.55422238
190Limited elbow extension (HP:0001377)1.55236548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.58070630
2CASK4.38713974
3ADRBK23.92048471
4GRK13.71156885
5ERBB42.89353491
6MARK12.73908718
7STK38L2.69012778
8NUAK12.46553992
9BUB12.45574089
10PDGFRA2.37539558
11TLK12.33360689
12DDR22.31047087
13WEE12.27837986
14LATS22.25868841
15TAOK32.17933807
16TXK2.16509922
17NTRK32.10859258
18MAPK132.06545821
19MAP4K21.92642898
20MAP3K41.91250999
21DYRK21.90692303
22TNIK1.89200926
23INSRR1.87035761
24BRSK21.86210167
25STK241.83743978
26NTRK21.81101189
27WNK41.80476371
28NEK11.71677587
29GRK71.67774579
30STK161.66954933
31BCR1.62888135
32PLK31.62415616
33VRK21.61620498
34MST41.61465056
35MAP2K71.58860007
36MINK11.56854139
37PAK31.53156701
38TAF11.51994284
39VRK11.48511487
40KDR1.45594101
41PDK21.40712534
42BRSK11.37577051
43ACVR1B1.34230247
44KSR21.32950096
45CSNK1G31.32198758
46MAP3K61.31026126
47MKNK21.29532402
48STK391.26900187
49OXSR11.25597754
50PRKD21.23330028
51PDK31.22422170
52PDK41.22422170
53PAK61.19998681
54CSNK1A1L1.19675988
55TEC1.19547936
56DAPK21.19419275
57PDGFRB1.16133318
58EPHB11.15899212
59EPHA21.15667154
60CSNK1G21.10055142
61WNK31.09827735
62KSR11.09326272
63AKT31.08873077
64NEK61.07384503
65BCKDK1.07316163
66PTK2B1.02332432
67PNCK1.02178813
68CHEK20.98479249
69RET0.96882343
70SRPK10.94753977
71TIE10.91748127
72IKBKB0.91386906
73PIK3CA0.91110002
74EIF2AK10.90954713
75BMPR1B0.89655046
76NME10.88917886
77PLK20.88100999
78CSNK1G10.86350788
79LMTK20.85876693
80PLK40.84118831
81BLK0.83339934
82AURKA0.82769029
83ERBB30.82168069
84GRK50.81830921
85MUSK0.80067923
86PRKCE0.79478076
87MAP2K40.79084082
88GRK60.75787124
89TYRO30.74895450
90CAMKK20.73706029
91BMPR20.72387790
92ZAK0.72119677
93FER0.70975950
94PHKG20.70147254
95PHKG10.70147254
96MAP2K60.69262116
97CDC70.68189254
98PLK10.67715902
99CDK80.66906190
100ITK0.66762187
101MAPKAPK50.66546963
102PINK10.65482980
103TTK0.65399308
104SGK4940.64783618
105SGK2230.64783618
106PTK20.63044467
107ERBB20.62742349
108CSNK1A10.61922088
109PRKCQ0.61672929
110PRKACA0.61610742
111LATS10.61481316
112ROCK10.61431987
113NTRK10.61417934
114CAMK2A0.60982615
115EPHB20.60081304
116CSNK1D0.59913511
117MAP3K120.58613282
118PRKG20.57275528
119PKN10.56524149
120MELK0.55499450
121SGK20.55099639
122MAP2K10.54632994
123MKNK10.54436838
124RPS6KA50.53951673
125MAPK150.53622566
126NLK0.53335885
127MOS0.52374429
128PRKCA0.52086068
129MAPKAPK30.51637863
130PRKCI0.51557820
131ADRBK10.51503578
132PRKD30.51093920
133STK380.50712526
134LYN0.50596391
135RPS6KA10.50502159
136SYK0.49647250
137DYRK1A0.48680456
138EPHA30.48607249
139IGF1R0.47975417
140TAOK10.47736368
141AURKB0.46977234
142OBSCN0.46188496
143MAP3K90.45054294
144PRKAA10.44420235
145EPHA40.43717368
146CDK30.42892693
147CSNK1E0.41657814
148PIM10.40324635
149ATR0.38703910
150PRKCG0.38562506
151TNK20.38426243
152ABL20.38415431
153CDK10.37767094
154SGK10.36256627
155MAPK100.36207750
156TRIM280.36180671
157CHEK10.34332136
158HIPK20.34046603
159MAP3K10.33600429
160PRKCH0.33043355
161KIT0.32888559
162RPS6KA60.32596812
163CAMK10.31245968

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.84152811
2Oxidative phosphorylation_Homo sapiens_hsa001902.85261574
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70786513
4RNA polymerase_Homo sapiens_hsa030202.69072093
5Cell cycle_Homo sapiens_hsa041102.62400917
6Phototransduction_Homo sapiens_hsa047442.55575398
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.40590763
8Circadian rhythm_Homo sapiens_hsa047102.37116062
9Nicotine addiction_Homo sapiens_hsa050332.34807942
10Oocyte meiosis_Homo sapiens_hsa041142.26507873
11ECM-receptor interaction_Homo sapiens_hsa045122.22325775
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21479094
13Parkinsons disease_Homo sapiens_hsa050122.18880682
14Nitrogen metabolism_Homo sapiens_hsa009102.17783255
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08277515
16Linoleic acid metabolism_Homo sapiens_hsa005912.03730363
17Homologous recombination_Homo sapiens_hsa034402.02112708
18Chemical carcinogenesis_Homo sapiens_hsa052041.92351542
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91832345
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85597086
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.84363289
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79075374
23Protein export_Homo sapiens_hsa030601.77493174
24Axon guidance_Homo sapiens_hsa043601.74568829
25Caffeine metabolism_Homo sapiens_hsa002321.72641081
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.70233734
27Primary immunodeficiency_Homo sapiens_hsa053401.69846990
28Sulfur metabolism_Homo sapiens_hsa009201.62821230
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61842115
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.61046996
31Retinol metabolism_Homo sapiens_hsa008301.60612777
32MicroRNAs in cancer_Homo sapiens_hsa052061.60219542
33Basal transcription factors_Homo sapiens_hsa030221.59568114
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.58653440
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57072773
36Tryptophan metabolism_Homo sapiens_hsa003801.56098100
37Alzheimers disease_Homo sapiens_hsa050101.55966815
38Gap junction_Homo sapiens_hsa045401.54202582
39Glioma_Homo sapiens_hsa052141.48176716
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45215750
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40701157
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40043391
43Huntingtons disease_Homo sapiens_hsa050161.38723453
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38420033
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37896133
46Hippo signaling pathway_Homo sapiens_hsa043901.37375966
47Melanoma_Homo sapiens_hsa052181.36341117
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34698111
49Protein digestion and absorption_Homo sapiens_hsa049741.34304844
50Sphingolipid metabolism_Homo sapiens_hsa006001.33894007
51Ribosome_Homo sapiens_hsa030101.33042195
52Amphetamine addiction_Homo sapiens_hsa050311.32999627
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28455704
54Glutamatergic synapse_Homo sapiens_hsa047241.26371710
55Olfactory transduction_Homo sapiens_hsa047401.20408812
56Fanconi anemia pathway_Homo sapiens_hsa034601.20330793
57GnRH signaling pathway_Homo sapiens_hsa049121.20011583
58RNA transport_Homo sapiens_hsa030131.19348500
59Asthma_Homo sapiens_hsa053101.18868557
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18171126
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16722971
62Hedgehog signaling pathway_Homo sapiens_hsa043401.16212388
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15485559
64TGF-beta signaling pathway_Homo sapiens_hsa043501.14461570
65Endometrial cancer_Homo sapiens_hsa052131.13839912
66Circadian entrainment_Homo sapiens_hsa047131.12078479
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11606787
68Fat digestion and absorption_Homo sapiens_hsa049751.11423187
69Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10120253
70Selenocompound metabolism_Homo sapiens_hsa004501.06681626
71Taste transduction_Homo sapiens_hsa047421.04336813
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01398645
73Ether lipid metabolism_Homo sapiens_hsa005651.00291438
74Ovarian steroidogenesis_Homo sapiens_hsa049131.00206687
75Spliceosome_Homo sapiens_hsa030400.99466896
76Glycerolipid metabolism_Homo sapiens_hsa005610.99314068
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98259940
78ErbB signaling pathway_Homo sapiens_hsa040120.96946503
79RNA degradation_Homo sapiens_hsa030180.95823655
80Oxytocin signaling pathway_Homo sapiens_hsa049210.95766109
81Butanoate metabolism_Homo sapiens_hsa006500.94317354
82Colorectal cancer_Homo sapiens_hsa052100.94024904
83Long-term depression_Homo sapiens_hsa047300.94000437
84Renal cell carcinoma_Homo sapiens_hsa052110.93119759
85Salivary secretion_Homo sapiens_hsa049700.92904892
86Focal adhesion_Homo sapiens_hsa045100.92764387
87Dopaminergic synapse_Homo sapiens_hsa047280.92154346
88Cocaine addiction_Homo sapiens_hsa050300.91759370
89Purine metabolism_Homo sapiens_hsa002300.90893752
90Pyrimidine metabolism_Homo sapiens_hsa002400.89958058
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89730422
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87837319
93Proteasome_Homo sapiens_hsa030500.86739818
94Other glycan degradation_Homo sapiens_hsa005110.86101497
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85754381
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84851295
97Cardiac muscle contraction_Homo sapiens_hsa042600.83497705
98Synaptic vesicle cycle_Homo sapiens_hsa047210.82281995
99p53 signaling pathway_Homo sapiens_hsa041150.82248491
100Systemic lupus erythematosus_Homo sapiens_hsa053220.82228971
101Serotonergic synapse_Homo sapiens_hsa047260.82148113
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81719080
103Bladder cancer_Homo sapiens_hsa052190.80793867
104Choline metabolism in cancer_Homo sapiens_hsa052310.80137160
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79683274
106Prion diseases_Homo sapiens_hsa050200.78861738
107GABAergic synapse_Homo sapiens_hsa047270.78323285
108Wnt signaling pathway_Homo sapiens_hsa043100.78297668
109MAPK signaling pathway_Homo sapiens_hsa040100.78029635
110Steroid biosynthesis_Homo sapiens_hsa001000.76888528
111Arachidonic acid metabolism_Homo sapiens_hsa005900.76419350
112Cholinergic synapse_Homo sapiens_hsa047250.76378948
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.76091473
114Dilated cardiomyopathy_Homo sapiens_hsa054140.75958635
115Vitamin digestion and absorption_Homo sapiens_hsa049770.75889123
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75766861
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74951447
118Graft-versus-host disease_Homo sapiens_hsa053320.74879758
119mRNA surveillance pathway_Homo sapiens_hsa030150.72508836
120Histidine metabolism_Homo sapiens_hsa003400.72501732
121Estrogen signaling pathway_Homo sapiens_hsa049150.72444512
122Tight junction_Homo sapiens_hsa045300.69871936
123Peroxisome_Homo sapiens_hsa041460.69832132
124Calcium signaling pathway_Homo sapiens_hsa040200.69638636
125FoxO signaling pathway_Homo sapiens_hsa040680.69132811
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68665676
127Prostate cancer_Homo sapiens_hsa052150.68121899
128Renin secretion_Homo sapiens_hsa049240.66808325
129Type I diabetes mellitus_Homo sapiens_hsa049400.66500664
130Vitamin B6 metabolism_Homo sapiens_hsa007500.65724824
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.65390868
132Hematopoietic cell lineage_Homo sapiens_hsa046400.64530887
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64344051
134Insulin secretion_Homo sapiens_hsa049110.64155338
135Allograft rejection_Homo sapiens_hsa053300.62449189
136Autoimmune thyroid disease_Homo sapiens_hsa053200.62343622
137Basal cell carcinoma_Homo sapiens_hsa052170.59718823
138Long-term potentiation_Homo sapiens_hsa047200.59225637
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59021942
140One carbon pool by folate_Homo sapiens_hsa006700.58872958
141Melanogenesis_Homo sapiens_hsa049160.57686466
142Nucleotide excision repair_Homo sapiens_hsa034200.57408891
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57122528
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56831599
145Renin-angiotensin system_Homo sapiens_hsa046140.56558748
146cAMP signaling pathway_Homo sapiens_hsa040240.56195434
147ABC transporters_Homo sapiens_hsa020100.56153935
148Morphine addiction_Homo sapiens_hsa050320.55525551
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55379921
150Central carbon metabolism in cancer_Homo sapiens_hsa052300.55141280
151Mineral absorption_Homo sapiens_hsa049780.54523815
152Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53657800
153Propanoate metabolism_Homo sapiens_hsa006400.53651896
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52045396
155Ras signaling pathway_Homo sapiens_hsa040140.50795081
156Glycosaminoglycan degradation_Homo sapiens_hsa005310.50428194
157Base excision repair_Homo sapiens_hsa034100.49336934
158Regulation of autophagy_Homo sapiens_hsa041400.49173050
159Pancreatic cancer_Homo sapiens_hsa052120.48913995
160Epstein-Barr virus infection_Homo sapiens_hsa051690.48068617
161Dorso-ventral axis formation_Homo sapiens_hsa043200.47295132
162Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46639583
163Metabolic pathways_Homo sapiens_hsa011000.42803336
164Collecting duct acid secretion_Homo sapiens_hsa049660.42678739
165Starch and sucrose metabolism_Homo sapiens_hsa005000.40616861
166Rheumatoid arthritis_Homo sapiens_hsa053230.39806384
167Gastric acid secretion_Homo sapiens_hsa049710.38662922
168Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36370079
169beta-Alanine metabolism_Homo sapiens_hsa004100.35258882

Most similar genes based on co-expression Upload to Enrichr

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