CHST13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by glucuronic acid residue in chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.55649827
2L-phenylalanine catabolic process (GO:0006559)6.55649827
3killing of cells in other organism involved in symbiotic interaction (GO:0051883)6.42121639
4disruption of cells of other organism involved in symbiotic interaction (GO:0051818)6.42121639
5L-phenylalanine metabolic process (GO:0006558)6.31402906
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.31402906
7aromatic amino acid family catabolic process (GO:0009074)5.96822077
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.72001324
9glyoxylate metabolic process (GO:0046487)5.55514604
10indole-containing compound catabolic process (GO:0042436)5.47544981
11indolalkylamine catabolic process (GO:0046218)5.47544981
12tryptophan catabolic process (GO:0006569)5.47544981
13kynurenine metabolic process (GO:0070189)5.39809432
14urea cycle (GO:0000050)5.31666483
15urea metabolic process (GO:0019627)5.31666483
16bile acid biosynthetic process (GO:0006699)5.28483754
17negative regulation of fibrinolysis (GO:0051918)5.25420667
18high-density lipoprotein particle remodeling (GO:0034375)5.25226289
19killing of cells of other organism (GO:0031640)5.24629026
20disruption of cells of other organism (GO:0044364)5.24629026
21sulfur amino acid catabolic process (GO:0000098)5.19001385
22tryptophan metabolic process (GO:0006568)5.09332798
23alpha-linolenic acid metabolic process (GO:0036109)5.07744122
24regulation of fibrinolysis (GO:0051917)5.00706230
25protein carboxylation (GO:0018214)4.98319782
26peptidyl-glutamic acid carboxylation (GO:0017187)4.98319782
27regulation of protein activation cascade (GO:2000257)4.97768603
28complement activation, alternative pathway (GO:0006957)4.97239625
29protein-lipid complex remodeling (GO:0034368)4.95431931
30macromolecular complex remodeling (GO:0034367)4.95431931
31plasma lipoprotein particle remodeling (GO:0034369)4.95431931
32nitrogen cycle metabolic process (GO:0071941)4.88240153
33cysteine metabolic process (GO:0006534)4.87778259
34regulation of triglyceride catabolic process (GO:0010896)4.75434818
35imidazole-containing compound metabolic process (GO:0052803)4.72951212
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.65007032
37regulation of complement activation (GO:0030449)4.64351225
38low-density lipoprotein particle remodeling (GO:0034374)4.61930355
39reverse cholesterol transport (GO:0043691)4.61097556
40positive regulation of fatty acid biosynthetic process (GO:0045723)4.54415880
41serine family amino acid catabolic process (GO:0009071)4.46605262
42bile acid metabolic process (GO:0008206)4.41794489
43glycine metabolic process (GO:0006544)4.37332110
44aromatic amino acid family metabolic process (GO:0009072)4.30197171
45amino-acid betaine metabolic process (GO:0006577)4.25994046
46regulation of cholesterol esterification (GO:0010872)4.25787974
47phospholipid efflux (GO:0033700)4.19246051
48serine family amino acid biosynthetic process (GO:0009070)4.18097757
49alpha-amino acid catabolic process (GO:1901606)4.13173202
50homocysteine metabolic process (GO:0050667)4.07033245
51serine family amino acid metabolic process (GO:0009069)4.04911476
52plasma lipoprotein particle clearance (GO:0034381)4.04587836
53acylglycerol homeostasis (GO:0055090)4.04490398
54triglyceride homeostasis (GO:0070328)4.04490398
55aggressive behavior (GO:0002118)4.01990248
56negative regulation of sterol transport (GO:0032372)4.01044111
57negative regulation of cholesterol transport (GO:0032375)4.01044111
58tyrosine metabolic process (GO:0006570)3.99986394
59lysine metabolic process (GO:0006553)3.99905140
60lysine catabolic process (GO:0006554)3.99905140
61plasma lipoprotein particle assembly (GO:0034377)3.92771209
62aldehyde catabolic process (GO:0046185)3.87975008
63plasma lipoprotein particle organization (GO:0071827)3.87129122
64defense response to fungus (GO:0050832)3.85734275
65cellular amino acid catabolic process (GO:0009063)3.81898092
66cholesterol efflux (GO:0033344)3.78455675
67cellular modified amino acid catabolic process (GO:0042219)3.76173250
68cellular ketone body metabolic process (GO:0046950)3.75929232
69cellular glucuronidation (GO:0052695)3.75019229
70fibrinolysis (GO:0042730)3.74521991
71indolalkylamine metabolic process (GO:0006586)3.74361718
72bile acid and bile salt transport (GO:0015721)3.74100853
73immunoglobulin mediated immune response (GO:0016064)3.71997761
74cellular biogenic amine catabolic process (GO:0042402)3.70902101
75amine catabolic process (GO:0009310)3.70902101
76positive regulation of B cell differentiation (GO:0045579)3.70514451
77phospholipid homeostasis (GO:0055091)3.68678779
78glutamate metabolic process (GO:0006536)3.68419294
79positive regulation of triglyceride lipase activity (GO:0061365)3.66615241
80positive regulation of lipoprotein lipase activity (GO:0051006)3.66615241
81coenzyme catabolic process (GO:0009109)3.64513628
82protein-lipid complex subunit organization (GO:0071825)3.63535447
83benzene-containing compound metabolic process (GO:0042537)3.63047402
84ethanol oxidation (GO:0006069)3.60417532
85blood coagulation, intrinsic pathway (GO:0007597)3.59084585
86regulation of mast cell degranulation (GO:0043304)3.54624711
87dicarboxylic acid biosynthetic process (GO:0043650)3.53383629
88very-low-density lipoprotein particle assembly (GO:0034379)3.52543828
89regulation of superoxide anion generation (GO:0032928)3.52225018
90protein-lipid complex assembly (GO:0065005)3.51510760
91positive regulation of lipid catabolic process (GO:0050996)3.51252991
92cholesterol homeostasis (GO:0042632)3.49878350
93arginine metabolic process (GO:0006525)3.49562331
94opsonization (GO:0008228)3.45872100
95nicotinamide nucleotide biosynthetic process (GO:0019359)3.45239227
96pyridine nucleotide biosynthetic process (GO:0019363)3.45239227
97pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.43557249
98deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43461483
99sterol homeostasis (GO:0055092)3.43121433
100complement activation (GO:0006956)3.42816307
101neutrophil activation involved in immune response (GO:0002283)3.41010890
102protein activation cascade (GO:0072376)3.40936484
103L-serine metabolic process (GO:0006563)3.40519988
104acute-phase response (GO:0006953)3.37157896
105carboxylic acid catabolic process (GO:0046395)3.35684836
106organic acid catabolic process (GO:0016054)3.35684836
107negative regulation of erythrocyte differentiation (GO:0045647)3.35426014
108complement activation, classical pathway (GO:0006958)3.33750057
109negative regulation of lipase activity (GO:0060192)3.31193850
110N-acetylneuraminate metabolic process (GO:0006054)3.29592496
111endothelium development (GO:0003158)3.28480718
112NAD biosynthetic process (GO:0009435)3.27564180
113female mating behavior (GO:0060180)3.27432879
114pinocytosis (GO:0006907)3.24935380
115regulation of mast cell activation involved in immune response (GO:0033006)3.22875047
116purine nucleotide salvage (GO:0032261)3.21272282
117positive regulation of mast cell activation involved in immune response (GO:0033008)3.21008023
118positive regulation of mast cell degranulation (GO:0043306)3.21008023
119purine deoxyribonucleotide catabolic process (GO:0009155)3.16319222
120positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.14750713
121regulation of hypersensitivity (GO:0002883)3.08344105
122deoxyribonucleotide catabolic process (GO:0009264)3.07266419
123oligosaccharide catabolic process (GO:0009313)3.05186930
124hyperosmotic salinity response (GO:0042538)3.04581483
125regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03968739
126regulation of plasminogen activation (GO:0010755)3.00824098
127amino sugar catabolic process (GO:0046348)2.99555634
128regulation of fatty acid biosynthetic process (GO:0042304)2.97309393
129negative regulation of myeloid cell apoptotic process (GO:0033033)2.97125722
130positive regulation of systemic arterial blood pressure (GO:0003084)2.94244760
131daunorubicin metabolic process (GO:0044597)2.94107811
132polyketide metabolic process (GO:0030638)2.94107811
133doxorubicin metabolic process (GO:0044598)2.94107811
134response to peptidoglycan (GO:0032494)2.92957537
135mature B cell differentiation involved in immune response (GO:0002313)2.92809285
136detection of bacterium (GO:0016045)2.89865605
137positive regulation of hemostasis (GO:1900048)2.88385700
138positive regulation of blood coagulation (GO:0030194)2.88385700
139positive regulation of prostaglandin secretion (GO:0032308)2.87707665
140deoxyribose phosphate catabolic process (GO:0046386)2.87347793
141positive regulation of megakaryocyte differentiation (GO:0045654)2.85006849
142pyrimidine nucleotide catabolic process (GO:0006244)2.83135631
143positive regulation of antigen processing and presentation (GO:0002579)2.82769996
144regulation of female receptivity (GO:0045924)2.80159070
145sterol catabolic process (GO:0016127)2.80117938
146cholesterol catabolic process (GO:0006707)2.80117938
147positive regulation of mast cell activation (GO:0033005)2.79438137
148positive regulation of gamma-delta T cell activation (GO:0046645)2.79192531
149autophagic vacuole fusion (GO:0000046)2.78387304
150detection of other organism (GO:0098543)2.78049317
151B cell mediated immunity (GO:0019724)2.76797623
152regulation of monocyte differentiation (GO:0045655)2.76398591
153negative regulation of digestive system process (GO:0060457)2.75835088
154regulation of leukocyte degranulation (GO:0043300)2.71663739
155negative regulation of blood coagulation (GO:0030195)2.71087429
156negative regulation of hemostasis (GO:1900047)2.71087429
157regulation of prostaglandin secretion (GO:0032306)2.70672643
158sodium-independent organic anion transport (GO:0043252)2.68658626
159definitive hemopoiesis (GO:0060216)2.67693483
160nucleotide salvage (GO:0043173)2.67285123
161Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66982771
162regulation of lipoprotein particle clearance (GO:0010984)2.65632427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.01764282
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.30264298
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.88587680
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.25337807
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.77906678
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.67697268
7BP1_19119308_ChIP-ChIP_Hs578T_Human4.40726377
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.08366499
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.93601911
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.06018476
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37184590
12* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00913678
13* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.00641902
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3493984
15MYC_22102868_ChIP-Seq_BL_Human1.94533314
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93983038
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.88428029
18ELF1_20517297_ChIP-Seq_JURKAT_Human1.82585767
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.81411397
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.79257138
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78067851
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.69298519
23GATA1_22025678_ChIP-Seq_K562_Human1.66121970
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65897326
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58830786
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.57856058
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53706074
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50964212
29P68_20966046_ChIP-Seq_HELA_Human1.49092637
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48087414
31CLOCK_20551151_ChIP-Seq_293T_Human1.46609649
32SPI1_23127762_ChIP-Seq_K562_Human1.46011679
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42906534
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42839432
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.41856376
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41625932
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.40213236
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.39005969
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35049036
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33609747
41PU.1_20513432_ChIP-Seq_Bcells_Mouse1.32536567
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.32198252
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28337143
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28129209
45CTCF_26484167_Chip-Seq_Bcells_Mouse1.27610731
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24915565
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24275220
48MAF_26560356_Chip-Seq_TH2_Human1.23979205
49* SA1_27219007_Chip-Seq_ERYTHROID_Human1.23937232
50VDR_21846776_ChIP-Seq_THP-1_Human1.23486821
51TCF7_22412390_ChIP-Seq_EML_Mouse1.22123596
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19198647
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15839009
54YY1_22570637_ChIP-Seq_MALME-3M_Human1.15472926
55HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15088956
56* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13581711
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12987323
58HNF4A_19822575_ChIP-Seq_HepG2_Human1.11558269
59* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11258908
60E2F1_20622854_ChIP-Seq_HELA_Human1.10371549
61PHF8_20622854_ChIP-Seq_HELA_Human1.10142443
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10072143
63RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09416083
64SCL_19346495_ChIP-Seq_HPC-7_Human1.08341464
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.08182210
66NCOR1_26117541_ChIP-Seq_K562_Human1.07135861
67KDM2B_26808549_Chip-Seq_DND41_Human1.05944153
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.04174188
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03923961
70SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03724376
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03597922
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01799348
73E2F7_22180533_ChIP-Seq_HELA_Human1.01538684
74IRF8_27001747_Chip-Seq_BMDM_Mouse0.99893800
75CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99699368
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98675047
77CTCF_21964334_Chip-Seq_Bcells_Human0.97699824
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96741715
79GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96714903
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95540182
81LXR_22292898_ChIP-Seq_THP-1_Human0.95039243
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93722499
83RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93207689
84GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92545913
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91384385
86HTT_18923047_ChIP-ChIP_STHdh_Human0.91011370
87SPI1_23547873_ChIP-Seq_NB4_Human0.89143308
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89007964
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88423340
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85208300
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84001698
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83624265
93AR_21909140_ChIP-Seq_LNCAP_Human0.83338357
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82475875
95SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82443660
96VDR_24763502_ChIP-Seq_THP-1_Human0.81825553
97RUNX1_22412390_ChIP-Seq_EML_Mouse0.81506006
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80958001
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80719581
100GATA1_19941827_ChIP-Seq_MEL_Mouse0.80604823
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80100247
102EGR1_19374776_ChIP-ChIP_THP-1_Human0.78852310
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78692401
104RARA_24833708_ChIP-Seq_LIVER_Mouse0.78329221
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.77434216
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77369660
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.77259260
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77204569
109EGR1_19032775_ChIP-ChIP_M12_Human0.75387608
110CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75363090
111* GATA4_25053715_ChIP-Seq_YYC3_Human0.74422369
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72175695
113CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70377668
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70055199
115ZNF263_19887448_ChIP-Seq_K562_Human0.67682541
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.67123211
117PU_27001747_Chip-Seq_BMDM_Mouse0.66961769
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66683225
119* UTX_26944678_Chip-Seq_JUKART_Human0.66334249
120SPI1_20517297_ChIP-Seq_HL60_Human0.66317576
121MAF_26560356_Chip-Seq_TH1_Human0.66241977
122BCOR_27268052_Chip-Seq_Bcells_Human0.65889322
123RARB_24833708_ChIP-Seq_LIVER_Mouse0.65742898
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.64246160
125* BCL6_27268052_Chip-Seq_Bcells_Human0.64205835
126MYB_26560356_Chip-Seq_TH1_Human0.63397776
127GATA1_19941826_ChIP-Seq_K562_Human0.61598875
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.61112087
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.60778540
130GATA2_19941826_ChIP-Seq_K562_Human0.60773612
131E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.60159113
132IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.59811755
133P300_27268052_Chip-Seq_Bcells_Human0.59433487
134MYC_18358816_ChIP-ChIP_MESCs_Mouse0.59251895
135PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57995440
136CEBPB_22108803_ChIP-Seq_LS180_Human0.57716459
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.57637005
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.57438988
139PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.57292955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.03923126
2MP0005360_urolithiasis6.81786360
3MP0005085_abnormal_gallbladder_physiolo5.49875393
4MP0005365_abnormal_bile_salt5.34546762
5MP0003806_abnormal_nucleotide_metabolis4.42076003
6MP0008875_abnormal_xenobiotic_pharmacok4.36127521
7MP0009840_abnormal_foam_cell3.52955201
8MP0010329_abnormal_lipoprotein_level3.40056828
9MP0003252_abnormal_bile_duct3.11856608
10MP0003191_abnormal_cellular_cholesterol2.80737650
11MP0005083_abnormal_biliary_tract2.56430902
12MP0005332_abnormal_amino_acid2.43279905
13MP0009278_abnormal_bone_marrow2.31660553
14MP0001666_abnormal_nutrient_absorption2.30128228
15MP0003195_calcinosis2.25497833
16MP0002148_abnormal_hypersensitivity_rea2.24960483
17MP0000609_abnormal_liver_physiology2.10281912
18MP0003436_decreased_susceptibility_to2.02360144
19MP0001764_abnormal_homeostasis2.01633901
20MP0002118_abnormal_lipid_homeostasis1.91697567
21MP0005319_abnormal_enzyme/_coenzyme1.87630442
22MP0004019_abnormal_vitamin_homeostasis1.86731094
23MP0003656_abnormal_erythrocyte_physiolo1.82897802
24MP0006082_CNS_inflammation1.77508352
25MP0005000_abnormal_immune_tolerance1.68535579
26MP0003303_peritoneal_inflammation1.67001276
27MP0003186_abnormal_redox_activity1.60013274
28MP0009333_abnormal_splenocyte_physiolog1.56772758
29MP0005584_abnormal_enzyme/coenzyme_acti1.54089796
30MP0001790_abnormal_immune_system1.53416827
31MP0005387_immune_system_phenotype1.53416827
32MP0002452_abnormal_antigen_presenting1.47944481
33MP0005464_abnormal_platelet_physiology1.46538161
34MP0002723_abnormal_immune_serum1.44423294
35MP0001800_abnormal_humoral_immune1.39665116
36MP0002138_abnormal_hepatobiliary_system1.38865018
37MP0003724_increased_susceptibility_to1.36587769
38MP0005671_abnormal_response_to1.35755556
39MP0009764_decreased_sensitivity_to1.34652681
40MP0003868_abnormal_feces_composition1.33809886
41MP0002420_abnormal_adaptive_immunity1.33595347
42MP0001819_abnormal_immune_cell1.33344524
43MP0003011_delayed_dark_adaptation1.30785887
44MP0009697_abnormal_copulation1.30552820
45MP0009785_altered_susceptibility_to1.28980663
46MP0000598_abnormal_liver_morphology1.26864958
47MP0002419_abnormal_innate_immunity1.26617717
48MP0008469_abnormal_protein_level1.25494536
49MP0009643_abnormal_urine_homeostasis1.23182493
50MP0009763_increased_sensitivity_to1.21886473
51MP0000604_amyloidosis1.21409551
52MP0005451_abnormal_body_composition1.21305103
53MP0002405_respiratory_system_inflammati1.15102604
54MP0002837_dystrophic_cardiac_calcinosis1.11716591
55MP0000689_abnormal_spleen_morphology1.10839837
56MP0001853_heart_inflammation1.08413998
57MP0000716_abnormal_immune_system1.07154743
58MP0010386_abnormal_urinary_bladder1.06107811
59MP0002398_abnormal_bone_marrow1.05546870
60MP0001533_abnormal_skeleton_physiology1.00408662
61MP0005025_abnormal_response_to0.99452384
62MP0005310_abnormal_salivary_gland0.98374387
63MP0005376_homeostasis/metabolism_phenot0.97198583
64MP0003705_abnormal_hypodermis_morpholog0.97173529
65MP0001851_eye_inflammation0.96901215
66MP0002429_abnormal_blood_cell0.95896621
67MP0006036_abnormal_mitochondrial_physio0.95328334
68MP0005636_abnormal_mineral_homeostasis0.94398955
69MP0002722_abnormal_immune_system0.94270035
70MP0005645_abnormal_hypothalamus_physiol0.94257774
71MP0003075_altered_response_to0.92380707
72MP0009642_abnormal_blood_homeostasis0.90451939
73MP0001845_abnormal_inflammatory_respons0.88423337
74MP0001663_abnormal_digestive_system0.85676717
75MP0005058_abnormal_lysosome_morphology0.84993302
76MP0009765_abnormal_xenobiotic_induced0.82482176
77MP0003718_maternal_effect0.82123664
78MP0005397_hematopoietic_system_phenotyp0.79723058
79MP0001545_abnormal_hematopoietic_system0.79723058
80MP0004883_abnormal_blood_vessel0.78748156
81MP0003866_abnormal_defecation0.78525319
82MP0005408_hypopigmentation0.77644715
83MP0003329_amyloid_beta_deposits0.74333854
84MP0003172_abnormal_lysosome_physiology0.74299630
85MP0005670_abnormal_white_adipose0.74202620
86MP0005165_increased_susceptibility_to0.74198832
87MP0002971_abnormal_brown_adipose0.74080867
88MP0005164_abnormal_response_to0.72993254
89MP0009053_abnormal_anal_canal0.72687603
90MP0005023_abnormal_wound_healing0.71970836
91MP0004808_abnormal_hematopoietic_stem0.69475214
92MP0005266_abnormal_metabolism0.69393381
93MP0005647_abnormal_sex_gland0.68913687
94MP0002166_altered_tumor_susceptibility0.68542474
95MP0002998_abnormal_bone_remodeling0.65387619
96MP0005410_abnormal_fertilization0.64690112
97MP0001661_extended_life_span0.63280749
98MP0000343_altered_response_to0.62784967
99MP0004264_abnormal_extraembryonic_tissu0.62437146
100MP0008873_increased_physiological_sensi0.62055314
101MP0002089_abnormal_postnatal_growth/wei0.61879415
102MP0003183_abnormal_peptide_metabolism0.61372937
103MP0000249_abnormal_blood_vessel0.60919761
104MP0005334_abnormal_fat_pad0.60622919
105MP0008260_abnormal_autophagy0.60147593
106MP0005166_decreased_susceptibility_to0.59905610
107MP0006054_spinal_hemorrhage0.59805069
108MP0002078_abnormal_glucose_homeostasis0.59513148
109MP0005220_abnormal_exocrine_pancreas0.59078707
110MP0003638_abnormal_response/metabolism_0.58741495
111MP0002254_reproductive_system_inflammat0.58677532
112MP0003300_gastrointestinal_ulcer0.57969996
113MP0006035_abnormal_mitochondrial_morpho0.56989526
114MP0005075_abnormal_melanosome_morpholog0.56908588
115MP0002876_abnormal_thyroid_physiology0.56366714
116MP0004381_abnormal_hair_follicle0.55345432
117MP0008874_decreased_physiological_sensi0.55089089
118MP0000685_abnormal_immune_system0.55066277
119MP0005167_abnormal_blood-brain_barrier0.54571253
120MP0000858_altered_metastatic_potential0.52021878
121MP0010155_abnormal_intestine_physiology0.51797647
122MP0001835_abnormal_antigen_presentation0.51675621
123MP0001756_abnormal_urination0.51544940
124MP0004782_abnormal_surfactant_physiolog0.51503509
125MP0005535_abnormal_body_temperature0.51117175
126MP0005084_abnormal_gallbladder_morpholo0.50397703
127MP0003690_abnormal_glial_cell0.49948057
128MP0000639_abnormal_adrenal_gland0.49555444
129MP0002396_abnormal_hematopoietic_system0.48799355
130MP0000465_gastrointestinal_hemorrhage0.47823363
131MP0002132_abnormal_respiratory_system0.46917699
132MP0002136_abnormal_kidney_physiology0.46890705
133MP0002060_abnormal_skin_morphology0.46141897
134MP0002970_abnormal_white_adipose0.44261769

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.67758229
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.20220126
3Intrahepatic cholestasis (HP:0001406)6.15954688
4Prolonged partial thromboplastin time (HP:0003645)6.14363239
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.89578190
6Hypobetalipoproteinemia (HP:0003563)5.70892237
7Xanthomatosis (HP:0000991)5.70241813
8Hyperlipoproteinemia (HP:0010980)5.04610625
9Joint hemorrhage (HP:0005261)4.79656863
10Abnormality of the common coagulation pathway (HP:0010990)4.77520089
11Complement deficiency (HP:0004431)4.66782322
12Purpura (HP:0000979)4.43991133
13Recurrent gram-negative bacterial infections (HP:0005420)4.22149058
14Increased cerebral lipofuscin (HP:0011813)4.20514798
15Hypolipoproteinemia (HP:0010981)4.17299700
16Hyperammonemia (HP:0001987)4.14286338
17Abnormality of glycolipid metabolism (HP:0010969)4.11673091
18Abnormality of liposaccharide metabolism (HP:0010968)4.11673091
19Abnormality of glycosphingolipid metabolism (HP:0004343)4.11673091
20Increased neuronal autofluorescent lipopigment (HP:0002074)4.01259691
21Hypoglycemic coma (HP:0001325)3.89797542
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.89190845
23Abnormality of pyrimidine metabolism (HP:0004353)3.87097138
24Abnormality of the intrinsic pathway (HP:0010989)3.79753428
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.70889557
26Hyperglycinemia (HP:0002154)3.69206474
27Abnormality of methionine metabolism (HP:0010901)3.67549254
28Ketosis (HP:0001946)3.64724976
29Abnormality of complement system (HP:0005339)3.61413898
30Myositis (HP:0100614)3.60047966
31Fat malabsorption (HP:0002630)3.59525897
32Prolonged bleeding time (HP:0003010)3.58050271
33Epidermoid cyst (HP:0200040)3.55585012
34Hypoalphalipoproteinemia (HP:0003233)3.51305854
35Petechiae (HP:0000967)3.50514989
36Abnormality of glutamine family amino acid metabolism (HP:0010902)3.50347262
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.49960245
38Obstructive lung disease (HP:0006536)3.47210964
39Chronic obstructive pulmonary disease (HP:0006510)3.47210964
40Dysostosis multiplex (HP:0000943)3.46426533
41Abnormality of fatty-acid metabolism (HP:0004359)3.45626726
42Abnormality of serine family amino acid metabolism (HP:0010894)3.40306228
43Abnormality of glycine metabolism (HP:0010895)3.40306228
44Hyperglycinuria (HP:0003108)3.34910855
45Vacuolated lymphocytes (HP:0001922)3.33543464
46Hyperbilirubinemia (HP:0002904)3.33083177
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30217471
48Conjugated hyperbilirubinemia (HP:0002908)3.23287514
49Stomatitis (HP:0010280)3.17627449
50Hypercholesterolemia (HP:0003124)3.17103171
51Elevated erythrocyte sedimentation rate (HP:0003565)2.90477307
52Abnormality of macrophages (HP:0004311)2.89276962
53Abnormality of nucleobase metabolism (HP:0010932)2.87778571
54Abnormality of polysaccharide metabolism (HP:0011012)2.83564504
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.83564504
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.83564504
57Orchitis (HP:0100796)2.81782871
58Delayed CNS myelination (HP:0002188)2.79795828
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.79365873
60Dicarboxylic aciduria (HP:0003215)2.79365873
61Systemic lupus erythematosus (HP:0002725)2.77902517
62Amyloidosis (HP:0011034)2.76982702
63Steatorrhea (HP:0002570)2.74139332
64Mucopolysacchariduria (HP:0008155)2.74080465
65Urinary glycosaminoglycan excretion (HP:0003541)2.74080465
66Gingival bleeding (HP:0000225)2.72612929
67Loss of speech (HP:0002371)2.71391850
68Mediastinal lymphadenopathy (HP:0100721)2.68341166
69Hepatocellular carcinoma (HP:0001402)2.68319199
70Abnormality of serum amino acid levels (HP:0003112)2.62506108
71Thrombophlebitis (HP:0004418)2.60936408
72Myocardial infarction (HP:0001658)2.59139307
73Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.58739594
74Hypertensive crisis (HP:0100735)2.55807530
75Spontaneous abortion (HP:0005268)2.53933113
76Eczematoid dermatitis (HP:0000976)2.49097004
77Acanthocytosis (HP:0001927)2.48477386
78Spastic diplegia (HP:0001264)2.47602506
79Mutism (HP:0002300)2.47015078
80Abnormality of iron homeostasis (HP:0011031)2.46788311
81Ketoacidosis (HP:0001993)2.44679117
82Pancreatitis (HP:0001733)2.43665258
83Generalized aminoaciduria (HP:0002909)2.43466683
84Increased muscle lipid content (HP:0009058)2.43043532
85Hypochromic microcytic anemia (HP:0004840)2.42781085
86Hepatosplenomegaly (HP:0001433)2.41770848
87Metabolic acidosis (HP:0001942)2.39505978
88Agammaglobulinemia (HP:0004432)2.39021714
89Abnormality of purine metabolism (HP:0004352)2.38119287
90Meningitis (HP:0001287)2.37237127
91Abnormality of transition element cation homeostasis (HP:0011030)2.34977342
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.34893103
93Opisthotonus (HP:0002179)2.34309742
94Retrobulbar optic neuritis (HP:0100654)2.31552230
95Optic neuritis (HP:0100653)2.31552230
96Panhypogammaglobulinemia (HP:0003139)2.31074381
97Recurrent bacterial skin infections (HP:0005406)2.30986377
98Increased intramyocellular lipid droplets (HP:0012240)2.30939319
99Abnormality of the heme biosynthetic pathway (HP:0010472)2.30315652
100Cellulitis (HP:0100658)2.28241112
101Lethargy (HP:0001254)2.27854791
102Vascular calcification (HP:0004934)2.26623913
103Prolonged neonatal jaundice (HP:0006579)2.26306825
104Spastic paraparesis (HP:0002313)2.24872530
105Recurrent fungal infections (HP:0002841)2.23441528
106Skin nodule (HP:0200036)2.23302513
107Autoimmune thrombocytopenia (HP:0001973)2.22990892
108Menorrhagia (HP:0000132)2.22193473
109Poikilocytosis (HP:0004447)2.17252352
110Pulmonary embolism (HP:0002204)2.16611518
111Epistaxis (HP:0000421)2.14870534
112Glomerulonephritis (HP:0000099)2.13298683
113Abnormal gallbladder morphology (HP:0012437)2.12781186
114Increased serum ferritin (HP:0003281)2.12670589
115Cholelithiasis (HP:0001081)2.10965482
116Thrombocytosis (HP:0001894)2.09660626
117Abnormal gallbladder physiology (HP:0012438)2.09566881
118Cholecystitis (HP:0001082)2.09566881
119Reduced antithrombin III activity (HP:0001976)2.05864623
120Episodic fever (HP:0001954)2.04355035
121Esophageal varix (HP:0002040)2.03568633
122Gangrene (HP:0100758)2.03455235
123Hemorrhage of the eye (HP:0011885)2.03225959
124Cerebral palsy (HP:0100021)2.02875950
125Gout (HP:0001997)2.02816116
126Thoracic kyphosis (HP:0002942)2.02455007
127Cerebral edema (HP:0002181)2.02353117
128Periodontitis (HP:0000704)2.02136970
129Disinhibition (HP:0000734)2.00506030
130Mitral stenosis (HP:0001718)2.00472874
131Upper motor neuron abnormality (HP:0002127)2.00355538
132Recurrent skin infections (HP:0001581)2.00087639
133Malnutrition (HP:0004395)1.99937749
134Progressive neurologic deterioration (HP:0002344)1.99511761
135Cardiovascular calcification (HP:0011915)1.98865661
136Late onset (HP:0003584)1.98510745
137Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96858950
138Retinal atrophy (HP:0001105)1.96370058
139Neonatal onset (HP:0003623)1.95234146
140Nausea (HP:0002018)1.95028846
141Irritability (HP:0000737)1.94891826
142Recurrent viral infections (HP:0004429)1.94680357
143Vomiting (HP:0002013)1.94288343
144Urticaria (HP:0001025)1.94205712
145Abnormal platelet volume (HP:0011876)1.91384055
146Hypoglycemic seizures (HP:0002173)1.90834142
147Hypertriglyceridemia (HP:0002155)1.90242186
148Recurrent abscess formation (HP:0002722)1.88980024
149Brushfield spots (HP:0001088)1.87945232
150Abnormal cartilage morphology (HP:0002763)1.87381481
151Arterial thrombosis (HP:0004420)1.87099449
152Xerostomia (HP:0000217)1.86485460
153Abnormal enzyme/coenzyme activity (HP:0012379)1.85740403
154Paraparesis (HP:0002385)1.85247586
155Epiphyseal stippling (HP:0010655)1.84902339
156Sensorimotor neuropathy (HP:0007141)1.84452781
157Encephalitis (HP:0002383)1.83440267
158Pulmonary infiltrates (HP:0002113)1.82818444
159Proximal tubulopathy (HP:0000114)1.82602096
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82032141
161Seborrheic dermatitis (HP:0001051)1.81999711
162Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80386285
163Renal cortical cysts (HP:0000803)1.78654869
164Elevated hepatic transaminases (HP:0002910)1.78267884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.44287514
2ERN14.74399869
3TAOK33.49913128
4NME23.29287619
5MAP2K32.85522708
6FGFR42.75238494
7PKN22.69062159
8TRIB32.62932518
9IRAK42.50815173
10SIK12.50277529
11GRK62.28682271
12EIF2AK32.27829952
13EPHB12.18102926
14VRK22.07888855
15KDR1.82723936
16TESK21.75944932
17FLT31.74081932
18BTK1.71514798
19ABL21.70079465
20TYK21.68583461
21STK161.68086539
22MAP3K111.66718254
23TEC1.60036876
24MAP3K31.58662556
25PIK3CG1.57181705
26BLK1.50564486
27MAPK111.49246401
28TGFBR21.45796305
29IKBKB1.42856264
30MAPK41.41779218
31TNK21.39238279
32JAK31.38277777
33PTK61.37398169
34NEK91.31740243
35CCNB11.31689876
36PBK1.31618756
37CSK1.24597632
38MAP3K121.23583925
39MATK1.22696186
40EPHA21.20928269
41FES1.19301968
42TAOK21.12622342
43JAK21.11399263
44CDK191.10471592
45MAP4K11.10051862
46ERBB41.09879155
47PAK41.08555380
48IRAK31.08074945
49GRK71.05601112
50EIF2AK11.03286687
51DYRK1B1.02796880
52TRPM71.02546769
53LRRK21.02496931
54RIPK41.01847532
55WEE11.01349244
56MAP2K41.00240383
57MAP3K61.00194563
58TBK10.98048235
59ZAP700.95062631
60STK100.95010805
61LCK0.93200404
62FGR0.90815443
63MAP3K50.89254338
64MST1R0.86152949
65ITK0.85775930
66MAP2K60.84550219
67MAP3K80.84295515
68PRPF4B0.84171014
69PRKD20.82497438
70TXK0.82319179
71TESK10.80176281
72ARAF0.79700672
73JAK10.79639122
74MAP3K100.77668670
75CSF1R0.76028474
76EEF2K0.75582573
77INSRR0.74876605
78HCK0.70435434
79NUAK10.69508338
80DAPK10.65637387
81SIK20.63769845
82CDK40.63177175
83MAP3K140.62817225
84PINK10.60190133
85TAOK10.58895823
86RPS6KB20.58661939
87MYLK0.56689235
88PTK20.54774822
89SYK0.52779602
90SMG10.52231344
91NEK10.51583919
92DAPK20.50172752
93BMX0.49848396
94MAP2K20.48163230
95PRKAA20.47849879
96MAPKAPK30.46982003
97MAP3K130.46603346
98IRAK20.46567216
99PIM10.46284935
100PRKACG0.45166480
101PRKCD0.44850101
102MAP3K10.44054136
103SCYL20.42084598
104LYN0.41419910
105KIT0.40891010
106AURKA0.40297716
107DDR20.40242008
108CDK60.39882606
109MAPK30.39841688
110PIM20.39632229
111PDPK10.39558797
112GRK10.38732342
113EIF2AK20.38218002
114PRKCZ0.37018061
115CAMK1D0.36451371
116NEK20.35912188
117DAPK30.35686736
118MARK20.34994760
119CAMKK20.34681497
120IKBKE0.34487365
121ADRBK20.33468464
122PRKG20.32911647
123PRKCQ0.32677837
124CDK90.32072103
125CAMKK10.31954445
126RIPK10.31504428
127CDK70.30898052
128FRK0.29212294
129RPS6KA50.29132114
130CDC42BPA0.29074244
131ABL10.28403936
132STK40.27868777
133RPS6KC10.27462967
134RPS6KL10.27462967
135RPS6KA60.27034872
136EGFR0.26721424
137CHUK0.22735940
138MAP4K20.22626033
139ATR0.22196880

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.29496973
2Nitrogen metabolism_Homo sapiens_hsa009103.31341835
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26613492
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06805673
5Arginine biosynthesis_Homo sapiens_hsa002202.92042989
6Complement and coagulation cascades_Homo sapiens_hsa046102.80339225
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.68260535
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58667467
9Tryptophan metabolism_Homo sapiens_hsa003802.44356072
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39745893
11Fatty acid degradation_Homo sapiens_hsa000712.32220884
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29632396
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27227233
14Histidine metabolism_Homo sapiens_hsa003402.24592822
15Staphylococcus aureus infection_Homo sapiens_hsa051502.08434621
16Asthma_Homo sapiens_hsa053102.07663509
17Peroxisome_Homo sapiens_hsa041462.07451125
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99531043
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.85634633
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83413377
21Chemical carcinogenesis_Homo sapiens_hsa052041.82932725
22Butanoate metabolism_Homo sapiens_hsa006501.80445626
23Caffeine metabolism_Homo sapiens_hsa002321.80035549
24beta-Alanine metabolism_Homo sapiens_hsa004101.77767106
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.72144731
26Propanoate metabolism_Homo sapiens_hsa006401.71033498
27Allograft rejection_Homo sapiens_hsa053301.69708177
28Selenocompound metabolism_Homo sapiens_hsa004501.67300972
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67155328
30PPAR signaling pathway_Homo sapiens_hsa033201.64453819
31Retinol metabolism_Homo sapiens_hsa008301.59944304
32Starch and sucrose metabolism_Homo sapiens_hsa005001.58398174
33Fatty acid metabolism_Homo sapiens_hsa012121.57965301
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57934592
35Phenylalanine metabolism_Homo sapiens_hsa003601.52788122
36Primary immunodeficiency_Homo sapiens_hsa053401.52574218
37Sulfur metabolism_Homo sapiens_hsa009201.45855030
38Biosynthesis of amino acids_Homo sapiens_hsa012301.45390697
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43327019
40Autoimmune thyroid disease_Homo sapiens_hsa053201.42818215
41Graft-versus-host disease_Homo sapiens_hsa053321.41605632
42Carbon metabolism_Homo sapiens_hsa012001.40493863
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39557018
44Pentose phosphate pathway_Homo sapiens_hsa000301.38799726
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38422022
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.36547178
47Antigen processing and presentation_Homo sapiens_hsa046121.28699536
48Tyrosine metabolism_Homo sapiens_hsa003501.27591836
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27574337
50Folate biosynthesis_Homo sapiens_hsa007901.24391055
51Rheumatoid arthritis_Homo sapiens_hsa053231.23373957
52Pyruvate metabolism_Homo sapiens_hsa006201.22083221
53Type I diabetes mellitus_Homo sapiens_hsa049401.22043786
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.20710262
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18332961
56Sulfur relay system_Homo sapiens_hsa041221.16323263
57Fatty acid elongation_Homo sapiens_hsa000621.16119128
58Fat digestion and absorption_Homo sapiens_hsa049751.15802911
59ABC transporters_Homo sapiens_hsa020101.14466643
60Bile secretion_Homo sapiens_hsa049761.12900703
61Glutathione metabolism_Homo sapiens_hsa004801.11903277
62Vitamin B6 metabolism_Homo sapiens_hsa007501.09746809
63Base excision repair_Homo sapiens_hsa034101.08733687
64One carbon pool by folate_Homo sapiens_hsa006701.08506792
65Cyanoamino acid metabolism_Homo sapiens_hsa004601.06804692
66Hematopoietic cell lineage_Homo sapiens_hsa046401.06648536
67Osteoclast differentiation_Homo sapiens_hsa043801.03563074
68Tuberculosis_Homo sapiens_hsa051521.02159629
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01677124
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96827111
71Arginine and proline metabolism_Homo sapiens_hsa003300.94899873
72Steroid biosynthesis_Homo sapiens_hsa001000.93961743
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84771376
74Vitamin digestion and absorption_Homo sapiens_hsa049770.84104421
75Malaria_Homo sapiens_hsa051440.79752319
76Lysine degradation_Homo sapiens_hsa003100.73884422
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71824135
78Galactose metabolism_Homo sapiens_hsa000520.69598535
79Phagosome_Homo sapiens_hsa041450.69131868
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69083865
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68090329
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.67992899
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65842814
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65257031
85Glycerolipid metabolism_Homo sapiens_hsa005610.62072434
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61770790
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60854080
88Herpes simplex infection_Homo sapiens_hsa051680.59526780
89* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57818569
90Platelet activation_Homo sapiens_hsa046110.54993595
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54781137
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53422023
93Fructose and mannose metabolism_Homo sapiens_hsa000510.52945647
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.52545966
95Metabolic pathways_Homo sapiens_hsa011000.50416006
96Acute myeloid leukemia_Homo sapiens_hsa052210.50126226
97African trypanosomiasis_Homo sapiens_hsa051430.46033304
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44167467
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43744351
100Salmonella infection_Homo sapiens_hsa051320.43150010
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42418337
102Mineral absorption_Homo sapiens_hsa049780.41416759
103Viral myocarditis_Homo sapiens_hsa054160.40084093
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32726955
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.27002391
106Renin-angiotensin system_Homo sapiens_hsa046140.24248580
107Insulin resistance_Homo sapiens_hsa049310.23406763
108Other glycan degradation_Homo sapiens_hsa005110.23055893
109Fatty acid biosynthesis_Homo sapiens_hsa000610.22200229
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.16245682
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15096805
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13508504
113Leishmaniasis_Homo sapiens_hsa051400.11886794
114Prion diseases_Homo sapiens_hsa050200.11766414
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11737901
116N-Glycan biosynthesis_Homo sapiens_hsa005100.10209448
117Systemic lupus erythematosus_Homo sapiens_hsa053220.03657602
118Arachidonic acid metabolism_Homo sapiens_hsa005900.02503995
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.01337648
120Lysosome_Homo sapiens_hsa041420.00118739
121Insulin signaling pathway_Homo sapiens_hsa04910-0.0837612
122Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0803086
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0795125
124Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0745256
125Bladder cancer_Homo sapiens_hsa05219-0.0546448
126AMPK signaling pathway_Homo sapiens_hsa04152-0.0520625
127Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0437694
128Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0347567
129Protein export_Homo sapiens_hsa03060-0.0216632
130Linoleic acid metabolism_Homo sapiens_hsa00591-0.0206004
131Legionellosis_Homo sapiens_hsa05134-0.0189992
132Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0040100
133Pertussis_Homo sapiens_hsa05133-0.0039472
134Glucagon signaling pathway_Homo sapiens_hsa04922-0.0005317

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