CHST11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.97876192
2positive regulation of gamma-delta T cell activation (GO:0046645)5.69545479
3keratan sulfate catabolic process (GO:0042340)5.49407777
4cartilage condensation (GO:0001502)5.03100029
5cell aggregation (GO:0098743)5.03100029
6response to peptidoglycan (GO:0032494)4.88974141
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.88341679
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.88341679
9modulation by symbiont of host immune response (GO:0052553)4.88341679
10positive regulation by symbiont of host defense response (GO:0052509)4.88341679
11modulation by symbiont of host defense response (GO:0052031)4.88341679
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.88341679
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.68412236
14negative regulation of cell killing (GO:0031342)4.68412236
15cellular extravasation (GO:0045123)4.63468401
16negative regulation of interleukin-12 production (GO:0032695)4.56809155
17neutrophil activation involved in immune response (GO:0002283)4.52376246
18* chondrocyte development (GO:0002063)4.46477668
19macrophage activation involved in immune response (GO:0002281)4.40200007
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.25119482
21negative regulation of erythrocyte differentiation (GO:0045647)4.07797657
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06986426
23collagen fibril organization (GO:0030199)4.04391572
24regulation of B cell receptor signaling pathway (GO:0050855)4.03722321
25regulation of gamma-delta T cell activation (GO:0046643)4.03245483
26detection of molecule of bacterial origin (GO:0032490)3.94012412
27antigen processing and presentation of endogenous antigen (GO:0019883)3.92467745
28detection of other organism (GO:0098543)3.91029196
29response to muramyl dipeptide (GO:0032495)3.87262734
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.84599345
31locomotory exploration behavior (GO:0035641)3.82322701
32positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.73903378
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.70763650
34regulation of mast cell degranulation (GO:0043304)3.64182262
35germinal center formation (GO:0002467)3.63317480
36regulation of gamma-delta T cell differentiation (GO:0045586)3.62261240
37positive regulation of B cell differentiation (GO:0045579)3.60797192
38lipopolysaccharide-mediated signaling pathway (GO:0031663)3.60432475
39detection of external biotic stimulus (GO:0098581)3.60341952
40immunoglobulin mediated immune response (GO:0016064)3.58215917
41regulation of interferon-beta biosynthetic process (GO:0045357)3.58185042
42COPI coating of Golgi vesicle (GO:0048205)3.57448143
43Golgi transport vesicle coating (GO:0048200)3.57448143
44detection of bacterium (GO:0016045)3.56442220
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54474452
46positive regulation of extracellular matrix organization (GO:1903055)3.54357889
47positive regulation of mast cell activation (GO:0033005)3.54191954
48negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.53850486
49leukocyte aggregation (GO:0070486)3.47772470
50* chondroitin sulfate biosynthetic process (GO:0030206)3.43406680
51myeloid cell activation involved in immune response (GO:0002275)3.42141157
52regulation of leukocyte degranulation (GO:0043300)3.39939922
53granulocyte activation (GO:0036230)3.38829400
54regulation of mast cell activation involved in immune response (GO:0033006)3.37015847
55respiratory burst (GO:0045730)3.36351181
56protein retention in ER lumen (GO:0006621)3.35519841
57neutrophil activation (GO:0042119)3.34580141
58response to host immune response (GO:0052572)3.33853766
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.33853766
60regulation of myeloid leukocyte mediated immunity (GO:0002886)3.32805329
61macrophage activation (GO:0042116)3.26145576
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.25988195
63positive regulation of mast cell activation involved in immune response (GO:0033008)3.24967720
64positive regulation of mast cell degranulation (GO:0043306)3.24967720
65positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.24435724
66microglial cell activation (GO:0001774)3.23327905
67B cell receptor signaling pathway (GO:0050853)3.19142186
68detection of biotic stimulus (GO:0009595)3.18296243
69negative regulation of T cell mediated immunity (GO:0002710)3.17918085
70regulation of mast cell activation (GO:0033003)3.16360875
71regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.12514019
72T-helper 1 type immune response (GO:0042088)3.11223155
73chondroitin sulfate catabolic process (GO:0030207)3.10448822
74response to host (GO:0075136)3.10342808
75response to host defenses (GO:0052200)3.10342808
76response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.10342808
77chondrocyte proliferation (GO:0035988)3.07438698
78negative regulation of lymphocyte mediated immunity (GO:0002707)3.06366665
79dermatan sulfate biosynthetic process (GO:0030208)3.05658664
80neutrophil mediated immunity (GO:0002446)3.04973114
81cellular response to thyroid hormone stimulus (GO:0097067)3.03969019
82regulation of B cell differentiation (GO:0045577)3.03447680
83positive regulation of leukocyte degranulation (GO:0043302)3.03135331
84positive thymic T cell selection (GO:0045059)3.00736470
85T cell migration (GO:0072678)3.00697264
86positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.00120513
87replacement ossification (GO:0036075)2.99908776
88endochondral ossification (GO:0001958)2.99908776
89response to protozoan (GO:0001562)2.99166343
90response to interleukin-15 (GO:0070672)2.98174613
91defense response to protozoan (GO:0042832)2.97971111
92interferon-gamma-mediated signaling pathway (GO:0060333)2.96359747
93negative regulation of leukocyte mediated immunity (GO:0002704)2.91480145
94dermatan sulfate metabolic process (GO:0030205)2.91335312
95negative thymic T cell selection (GO:0045060)2.89727548
96proteoglycan metabolic process (GO:0006029)2.89128714
97positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.88271597
98collagen catabolic process (GO:0030574)2.88251900
99cellular response to type I interferon (GO:0071357)2.86962197
100type I interferon signaling pathway (GO:0060337)2.86962197
101positive regulation of p38MAPK cascade (GO:1900745)2.86823398
102regulation of tolerance induction (GO:0002643)2.86785516
103response to type I interferon (GO:0034340)2.84222364
104NIK/NF-kappaB signaling (GO:0038061)2.83469918
105regulation of T cell tolerance induction (GO:0002664)2.83302556
106cartilage development (GO:0051216)2.83183202
107leukocyte degranulation (GO:0043299)2.81153011
108myeloid dendritic cell activation (GO:0001773)2.80608775
109regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.79059785
110negative T cell selection (GO:0043383)2.78674425
111myeloid dendritic cell differentiation (GO:0043011)2.78360433
112negative regulation of interleukin-17 production (GO:0032700)2.77794128
113positive regulation of chondrocyte differentiation (GO:0032332)2.77702509
114regulation of regulated secretory pathway (GO:1903305)2.75581191
115regulation of extracellular matrix disassembly (GO:0010715)2.75475158
116myeloid leukocyte activation (GO:0002274)2.74911489
117neutrophil chemotaxis (GO:0030593)2.73626257
118negative regulation of cytokine production involved in immune response (GO:0002719)2.73517877
119positive regulation of interferon-alpha production (GO:0032727)2.73054094
120collagen metabolic process (GO:0032963)2.71670667
121tolerance induction (GO:0002507)2.71629939
122regulation of interferon-alpha production (GO:0032647)2.70927356
123keratan sulfate metabolic process (GO:0042339)2.70578258
124B cell mediated immunity (GO:0019724)2.67094358
125keratan sulfate biosynthetic process (GO:0018146)2.66929222
126hypotonic response (GO:0006971)2.66821156
127protein localization to endosome (GO:0036010)2.66164769
128neutrophil migration (GO:1990266)2.66083893
129multicellular organismal catabolic process (GO:0044243)2.58374221
130negative regulation of bone resorption (GO:0045779)2.58143901
131chondrocyte differentiation (GO:0002062)2.56348454
132exploration behavior (GO:0035640)2.55975240
133multicellular organismal macromolecule metabolic process (GO:0044259)2.53626903
134proline transport (GO:0015824)2.51729281
135negative regulation of bone remodeling (GO:0046851)2.50279206
136positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.50028223
137regulation of macrophage cytokine production (GO:0010935)2.49708579
138type B pancreatic cell development (GO:0003323)2.47291076
139embryonic skeletal joint morphogenesis (GO:0060272)2.44565885
140peptidyl-proline hydroxylation (GO:0019511)2.42764753
141positive regulation of vesicle fusion (GO:0031340)2.42555343
142regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.41298036
143glycosaminoglycan catabolic process (GO:0006027)2.40965713
144negative regulation of fatty acid transport (GO:2000192)2.40680123
145endodermal cell differentiation (GO:0035987)2.40550570
146synaptic vesicle maturation (GO:0016188)2.40395074
147response to gravity (GO:0009629)2.40329043
148* chondroitin sulfate metabolic process (GO:0030204)2.37673142
149bone resorption (GO:0045453)2.37379608
150multicellular organismal metabolic process (GO:0044236)2.36967574
151endothelial cell morphogenesis (GO:0001886)2.35449117
152positive regulation of cartilage development (GO:0061036)2.35272560
153positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.34420233
154alanine transport (GO:0032328)2.33562635
155regulation of beta-amyloid formation (GO:1902003)2.32889691
156notochord development (GO:0030903)2.31996081
157negative regulation of tissue remodeling (GO:0034104)2.31550465
158extracellular matrix disassembly (GO:0022617)2.31298409
159positive regulation of macrophage cytokine production (GO:0060907)2.30368072
160negative regulation of gluconeogenesis (GO:0045721)2.30323086
161limb bud formation (GO:0060174)2.29883955
162sphingomyelin metabolic process (GO:0006684)2.28735976
163aminoglycan catabolic process (GO:0006026)2.24606523
164vesicle coating (GO:0006901)2.23974478
165positive regulation of astrocyte differentiation (GO:0048711)2.22821448
166positive regulation of hormone biosynthetic process (GO:0046886)2.21792630
167positive regulation of cellular amide metabolic process (GO:0034250)2.21168932
168activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.20797799
169decidualization (GO:0046697)2.20520240
170regulation of type B pancreatic cell apoptotic process (GO:2000674)2.20337548
171regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.19307537
172positive regulation of axon extension (GO:0045773)2.19090974
173growth hormone receptor signaling pathway (GO:0060396)2.18561962
174regulation of synapse structural plasticity (GO:0051823)2.17688475
175regulation of fever generation (GO:0031620)2.15890159
176negative regulation of bone mineralization (GO:0030502)2.11541260
177* glycosaminoglycan biosynthetic process (GO:0006024)2.11457083
178positive regulation of heat generation (GO:0031652)2.10314769
179regulation of interleukin-12 biosynthetic process (GO:0045075)2.08457133
180retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.08183202
181glycoprotein metabolic process (GO:0009100)2.07776955
182regulation of chondrocyte differentiation (GO:0032330)2.07599064
183positive regulation of nitric-oxide synthase activity (GO:0051000)2.07057819
184regulation of bone mineralization (GO:0030500)2.06353636
185* aminoglycan biosynthetic process (GO:0006023)2.06324397
186positive regulation of nuclease activity (GO:0032075)2.05993699
187stress fiber assembly (GO:0043149)2.05793391
188adenosine receptor signaling pathway (GO:0001973)2.04979125
189regulation of glutamate receptor signaling pathway (GO:1900449)2.03466516
190sodium ion export (GO:0071436)2.03291500
191cellular response to growth hormone stimulus (GO:0071378)2.03291452
192regulation of cartilage development (GO:0061035)2.02843412
193positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.02526458
194cellular response to vitamin D (GO:0071305)2.02252237
195response to vitamin D (GO:0033280)2.02081357
196endoplasmic reticulum unfolded protein response (GO:0030968)2.01940062
197* mucopolysaccharide metabolic process (GO:1903510)2.00710299
198negative regulation of biomineral tissue development (GO:0070168)2.00162361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.04262206
2* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.59034713
3NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.08657735
4VDR_21846776_ChIP-Seq_THP-1_Human3.08212229
5AR_21572438_ChIP-Seq_LNCaP_Human2.93926311
6VDR_24763502_ChIP-Seq_THP-1_Human2.82628910
7SCL_19346495_ChIP-Seq_HPC-7_Human2.71103867
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.67893242
9MYC_22102868_ChIP-Seq_BL_Human2.57403216
10* SPI1_23547873_ChIP-Seq_NB4_Human2.53216763
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42199212
12* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.38133074
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35799568
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.34679968
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.29905388
16* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.26953588
17MAF_26560356_Chip-Seq_TH1_Human2.26277666
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.23665424
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22260989
20* MYB_26560356_Chip-Seq_TH2_Human2.17573893
21RUNX1_22412390_ChIP-Seq_EML_Mouse2.13699834
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09398414
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06442533
24TCF7_22412390_ChIP-Seq_EML_Mouse2.03782264
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03760931
26* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.00316355
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97608709
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.96146584
29UTX_26944678_Chip-Seq_JUKART_Human1.93286950
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93263113
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93263113
32GATA1_22025678_ChIP-Seq_K562_Human1.90751948
33* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90232067
34* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86280795
35MYB_26560356_Chip-Seq_TH1_Human1.84039071
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.83877247
37* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81638239
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.76896052
39* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.76304937
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.75988106
41* KDM2B_26808549_Chip-Seq_DND41_Human1.73571136
42* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72791952
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71573056
44* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70578439
45* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68787260
46* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68495561
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66310712
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66185524
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.63507269
50* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60749615
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.60022896
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.59361197
53* EED_16625203_ChIP-ChIP_MESCs_Mouse1.57824718
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57085453
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56787484
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.56782870
57* MAF_26560356_Chip-Seq_TH2_Human1.54996739
58VDR_24787735_ChIP-Seq_THP-1_Human1.54490709
59* PU_27001747_Chip-Seq_BMDM_Mouse1.52845888
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51630917
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50228119
62* GATA1_19941826_ChIP-Seq_K562_Human1.50114175
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49651455
64* RNF2_27304074_Chip-Seq_ESCs_Mouse1.49195156
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.47149097
66GATA3_27048872_Chip-Seq_THYMUS_Human1.45781642
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45495133
68CJUN_26792858_Chip-Seq_BT549_Human1.44458938
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43745270
70RXR_22108803_ChIP-Seq_LS180_Human1.42454755
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39396944
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39173351
73* KDM2B_26808549_Chip-Seq_K562_Human1.38792250
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38308714
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37870218
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37183100
77* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37107638
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.34354060
79DROSHA_22980978_ChIP-Seq_HELA_Human1.33930306
80BP1_19119308_ChIP-ChIP_Hs578T_Human1.33023082
81* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31182132
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31157522
83GBX2_23144817_ChIP-Seq_PC3_Human1.29320999
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29301863
85TP53_18474530_ChIP-ChIP_U2OS_Human1.28458313
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27616635
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26453223
88* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25867975
89* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25867975
90LXR_22292898_ChIP-Seq_THP-1_Human1.25070588
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24883816
92* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24782581
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24742922
94* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24714867
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24577872
96* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24523442
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23410815
98EZH2_22144423_ChIP-Seq_EOC_Human1.23160069
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23134640
100PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21964513
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21895061
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19922682
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19619517
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19370791
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17435316
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.17013922
107* GATA2_19941826_ChIP-Seq_K562_Human1.16046284
108NCOR1_26117541_ChIP-Seq_K562_Human1.15359337
109* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13955214
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13859503
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13756986
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13677848
113* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13236812
114GATA2_21666600_ChIP-Seq_HMVEC_Human1.12973634
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12796427
116* EZH2_27294783_Chip-Seq_ESCs_Mouse1.11813361
117* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11366916
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11311960
119* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09980901
120TFEB_21752829_ChIP-Seq_HELA_Human1.09842579
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09280369
122* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09143027
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08125589
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06967296
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06728235
126FOXO3_23340844_ChIP-Seq_DLD1_Human1.06692392
127* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05917110
128RARB_27405468_Chip-Seq_BRAIN_Mouse1.03518057
129GATA3_26560356_Chip-Seq_TH2_Human1.03276284
130JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03118691
131* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02753162
132TP53_16413492_ChIP-PET_HCT116_Human1.02475280
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01491319
134MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01328738
135IRF8_27001747_Chip-Seq_BMDM_Mouse1.00711447
136* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99521444
137SMAD4_21799915_ChIP-Seq_A2780_Human0.99499034
138* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99267511
139ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99065577
140BRD4_25478319_ChIP-Seq_HGPS_Human0.98974953
141SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98479384
142TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98261861
143* RUNX_20019798_ChIP-Seq_JUKART_Human0.98135886
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97466957
145PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95933179
146PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94521569
147P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93897662
148* SOX2_20726797_ChIP-Seq_SW620_Human0.93761048
149TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93520014
150CLOCK_20551151_ChIP-Seq_293T_Human0.93275574
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92870729
152* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92156890
153* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91568809
154IRF8_21731497_ChIP-ChIP_J774_Mouse0.91241527
155* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90839043
156* SOX2_21211035_ChIP-Seq_LN229_Gbm0.90092988
157RING1B_27294783_Chip-Seq_ESCs_Mouse0.89371142
158CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87763592
159PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87297398
160* PIAS1_25552417_ChIP-Seq_VCAP_Human0.86304468
161* KDM2B_26808549_Chip-Seq_JURKAT_Human0.86192338
162* TP63_23658742_ChIP-Seq_EP156T_Human0.85627506
163CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85320579
164PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84535195
165ESR1_20079471_ChIP-ChIP_T-47D_Human0.84460207
166* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84396849
167SPI1_23127762_ChIP-Seq_K562_Human0.84163471
168* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83772099
169* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.83611907
170GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82500672
171KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.78567177
172FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.77308562
173VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75824134

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo4.29970379
2MP0003724_increased_susceptibility_to3.52287532
3MP0002909_abnormal_adrenal_gland3.23935590
4MP0002933_joint_inflammation3.22760872
5MP0005503_abnormal_tendon_morphology3.09787738
6MP0004134_abnormal_chest_morphology2.93435923
7MP0005671_abnormal_response_to2.75764399
8MP0002877_abnormal_melanocyte_morpholog2.74666807
9MP0002282_abnormal_trachea_morphology2.68911633
10MP0004859_abnormal_synaptic_plasticity2.64454468
11MP0002148_abnormal_hypersensitivity_rea2.62337696
12MP0006082_CNS_inflammation2.59545099
13MP0005025_abnormal_response_to2.56792940
14MP0003303_peritoneal_inflammation2.52520314
15MP0005058_abnormal_lysosome_morphology2.50460666
16MP0009785_altered_susceptibility_to2.47280377
17MP0002896_abnormal_bone_mineralization2.45500227
18* MP0000163_abnormal_cartilage_morphology2.45465997
19MP0001800_abnormal_humoral_immune2.45062766
20MP0003191_abnormal_cellular_cholesterol2.41413514
21MP0002452_abnormal_antigen_presenting2.39221156
22MP0002089_abnormal_postnatal_growth/wei2.34539723
23MP0002723_abnormal_immune_serum2.32578518
24MP0002420_abnormal_adaptive_immunity2.26446631
25MP0001299_abnormal_eye_distance/2.25174620
26MP0001819_abnormal_immune_cell2.24384371
27MP0001533_abnormal_skeleton_physiology2.23219735
28* MP0002115_abnormal_skeleton_extremities2.22689222
29MP0008438_abnormal_cutaneous_collagen2.20234291
30MP0005464_abnormal_platelet_physiology2.19373442
31* MP0009250_abnormal_appendicular_skeleto2.15812354
32MP0004858_abnormal_nervous_system2.13151192
33MP0005451_abnormal_body_composition2.12112413
34MP0003283_abnormal_digestive_organ2.08606399
35MP0002405_respiratory_system_inflammati1.96867727
36MP0003172_abnormal_lysosome_physiology1.94778607
37MP0003763_abnormal_thymus_physiology1.94644628
38MP0002998_abnormal_bone_remodeling1.92662770
39MP0004947_skin_inflammation1.90579644
40MP0005397_hematopoietic_system_phenotyp1.89286280
41MP0001545_abnormal_hematopoietic_system1.89286280
42* MP0002113_abnormal_skeleton_development1.86966288
43MP0005390_skeleton_phenotype1.84426755
44MP0003279_aneurysm1.80335033
45MP0003091_abnormal_cell_migration1.79650104
46MP0003300_gastrointestinal_ulcer1.77025458
47MP0002398_abnormal_bone_marrow1.76556258
48MP0008260_abnormal_autophagy1.74618224
49MP0000716_abnormal_immune_system1.73508476
50MP0003646_muscle_fatigue1.69756847
51MP0005508_abnormal_skeleton_morphology1.69650104
52MP0005076_abnormal_cell_differentiation1.69063531
53MP0009840_abnormal_foam_cell1.68846077
54MP0001853_heart_inflammation1.67922643
55MP0003656_abnormal_erythrocyte_physiolo1.66809387
56MP0003795_abnormal_bone_structure1.66807939
57MP0003828_pulmonary_edema1.66452985
58MP0001845_abnormal_inflammatory_respons1.65088089
59MP0009333_abnormal_splenocyte_physiolog1.64762181
60MP0003436_decreased_susceptibility_to1.63464473
61MP0003075_altered_response_to1.63352380
62MP0001958_emphysema1.62886608
63MP0009764_decreased_sensitivity_to1.56583142
64MP0000569_abnormal_digit_pigmentation1.55333307
65MP0010155_abnormal_intestine_physiology1.55309044
66MP0001270_distended_abdomen1.55190739
67MP0005623_abnormal_meninges_morphology1.50438706
68MP0004510_myositis1.49873121
69MP0002396_abnormal_hematopoietic_system1.48074195
70MP0000689_abnormal_spleen_morphology1.45367046
71MP0002722_abnormal_immune_system1.45068899
72MP0000465_gastrointestinal_hemorrhage1.44537542
73MP0002429_abnormal_blood_cell1.41621863
74MP0000858_altered_metastatic_potential1.41616665
75MP0004808_abnormal_hematopoietic_stem1.39150978
76MP0001542_abnormal_bone_strength1.37062998
77MP0003566_abnormal_cell_adhesion1.36711973
78MP0008469_abnormal_protein_level1.35886431
79MP0005164_abnormal_response_to1.29450749
80MP0003690_abnormal_glial_cell1.27095394
81MP0009384_cardiac_valve_regurgitation1.25635940
82MP0003045_fibrosis1.25330381
83MP0001348_abnormal_lacrimal_gland1.24782794
84MP0000703_abnormal_thymus_morphology1.22869393
85* MP0002109_abnormal_limb_morphology1.21418484
86MP0000685_abnormal_immune_system1.20988815
87MP0002254_reproductive_system_inflammat1.19177966
88MP0003635_abnormal_synaptic_transmissio1.14809497
89MP0001851_eye_inflammation1.12006999
90MP0010352_gastrointestinal_tract_polyps1.11466669
91MP0000013_abnormal_adipose_tissue1.09305047
92MP0004381_abnormal_hair_follicle1.08539916
93MP0003453_abnormal_keratinocyte_physiol1.08096613
94MP0002163_abnormal_gland_morphology1.07939701
95* MP0002116_abnormal_craniofacial_bone1.04735325
96MP0003183_abnormal_peptide_metabolism1.03265845
97MP0000015_abnormal_ear_pigmentation1.00734998
98MP0003329_amyloid_beta_deposits1.00498308
99MP0004272_abnormal_basement_membrane1.00356735
100MP0000343_altered_response_to0.97926823
101MP0001835_abnormal_antigen_presentation0.97586332
102MP0002063_abnormal_learning/memory/cond0.97151849
103MP0003705_abnormal_hypodermis_morpholog0.95911614
104MP0004270_analgesia0.95660583
105MP0003448_altered_tumor_morphology0.93905477
106MP0002735_abnormal_chemical_nociception0.93781862
107MP0008004_abnormal_stomach_pH0.92453786
108MP0003866_abnormal_defecation0.92204416
109MP0000678_abnormal_parathyroid_gland0.91911440
110MP0005387_immune_system_phenotype0.91134681
111MP0001790_abnormal_immune_system0.91134681
112MP0009763_increased_sensitivity_to0.88384410
113MP0003755_abnormal_palate_morphology0.85603017
114MP0010386_abnormal_urinary_bladder0.85425132
115MP0009278_abnormal_bone_marrow0.83845518
116MP0002419_abnormal_innate_immunity0.83340429
117MP0005379_endocrine/exocrine_gland_phen0.82216931
118MP0002166_altered_tumor_susceptibility0.82080867
119MP0005166_decreased_susceptibility_to0.80838402
120MP0005023_abnormal_wound_healing0.80683191
121MP0000751_myopathy0.78380326
122MP0000428_abnormal_craniofacial_morphol0.78302736
123MP0000920_abnormal_myelination0.78103717
124MP0000371_diluted_coat_color0.77514855
125MP0005275_abnormal_skin_tensile0.76335996
126MP0006054_spinal_hemorrhage0.75421119
127MP0000249_abnormal_blood_vessel0.74874383
128MP0001873_stomach_inflammation0.74496857
129MP0009765_abnormal_xenobiotic_induced0.74282601
130MP0001501_abnormal_sleep_pattern0.74254803
131MP0000432_abnormal_head_morphology0.74113460
132MP0002108_abnormal_muscle_morphology0.73766352
133MP0008961_abnormal_basal_metabolism0.73220940
134MP0005310_abnormal_salivary_gland0.72787757
135MP0009745_abnormal_behavioral_response0.72646282
136MP0005000_abnormal_immune_tolerance0.70496666
137MP0000733_abnormal_muscle_development0.69837767
138MP0005167_abnormal_blood-brain_barrier0.69651576
139MP0002132_abnormal_respiratory_system0.69294116
140MP0002332_abnormal_exercise_endurance0.67707721
141MP0000534_abnormal_ureter_morphology0.67693233
142MP0002693_abnormal_pancreas_physiology0.65452083
143MP0003221_abnormal_cardiomyocyte_apopto0.64686034
144MP0001663_abnormal_digestive_system0.64623845
145MP0004883_abnormal_blood_vessel0.64541117
146MP0002006_tumorigenesis0.64222622
147MP0000049_abnormal_middle_ear0.64095055
148MP0002736_abnormal_nociception_after0.64077082
149MP0003941_abnormal_skin_development0.63819926
150MP0000767_abnormal_smooth_muscle0.63819009
151MP0008874_decreased_physiological_sensi0.63354505
152MP0005075_abnormal_melanosome_morpholog0.62149038
153MP0002064_seizures0.61548936
154MP0001968_abnormal_touch/_nociception0.61514893
155MP0004484_altered_response_of0.60566906
156MP0001765_abnormal_ion_homeostasis0.60157128
157MP0002734_abnormal_mechanical_nocicepti0.59927193
158MP0003935_abnormal_craniofacial_develop0.59904569
159MP0000490_abnormal_crypts_of0.59493813
160MP0003385_abnormal_body_wall0.58129058
161MP0000604_amyloidosis0.57987933
162MP0000681_abnormal_thyroid_gland0.57820974
163MP0002277_abnormal_respiratory_mucosa0.56676903
164MP0004185_abnormal_adipocyte_glucose0.54950948
165MP0003806_abnormal_nucleotide_metabolis0.54885648
166MP0005621_abnormal_cell_physiology0.51682703

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)8.60468997
2Irregular epiphyses (HP:0010582)6.85510911
3Eczematoid dermatitis (HP:0000976)5.65666080
4Vitreoretinal degeneration (HP:0000655)5.65234721
5Hypoplastic ischia (HP:0003175)5.38940657
6Small epiphyses (HP:0010585)5.38355729
7Recurrent bacterial skin infections (HP:0005406)5.37607931
8Recurrent abscess formation (HP:0002722)5.25095172
9Abnormality of macrophages (HP:0004311)5.12692029
10Cupped ribs (HP:0000887)4.89116540
11Abnormality of glycolipid metabolism (HP:0010969)4.84936232
12Abnormality of liposaccharide metabolism (HP:0010968)4.84936232
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.84936232
14Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.76397034
15Abnormality of the ischium (HP:0003174)4.75043769
16Flat capital femoral epiphysis (HP:0003370)4.66795978
17Delayed epiphyseal ossification (HP:0002663)4.53601445
18Abnormal tarsal ossification (HP:0008369)4.31179157
19Flat acetabular roof (HP:0003180)4.24773693
20Myositis (HP:0100614)4.13143318
21Genu varum (HP:0002970)3.98873552
22Recurrent gram-negative bacterial infections (HP:0005420)3.97986800
23Mediastinal lymphadenopathy (HP:0100721)3.92941840
24Orchitis (HP:0100796)3.92010596
25Flattened epiphyses (HP:0003071)3.89128519
26Neonatal short-limb short stature (HP:0008921)3.87598139
27Metaphyseal cupping (HP:0003021)3.87584333
28Cervical subluxation (HP:0003308)3.86097650
29Mild short stature (HP:0003502)3.77753571
30Stomatitis (HP:0010280)3.68962028
31Increased cerebral lipofuscin (HP:0011813)3.68596628
32Retrobulbar optic neuritis (HP:0100654)3.67843415
33Optic neuritis (HP:0100653)3.67843415
34Recurrent fungal infections (HP:0002841)3.66479217
35Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.62525176
36Abnormality of femoral epiphyses (HP:0006499)3.62525176
37Abnormality of the vertebral endplates (HP:0005106)3.61071211
38Osteoarthritis (HP:0002758)3.60346064
39Obstructive lung disease (HP:0006536)3.44657787
40Chronic obstructive pulmonary disease (HP:0006510)3.44657787
41Recurrent skin infections (HP:0001581)3.43007656
42Abnormal foot bone ossification (HP:0010675)3.34921885
43Abnormality of the epiphysis of the femoral head (HP:0010574)3.28338113
44Absent frontal sinuses (HP:0002688)3.27051477
45Elevated erythrocyte sedimentation rate (HP:0003565)3.21116374
46Vacuolated lymphocytes (HP:0001922)3.20933882
47Irregular vertebral endplates (HP:0003301)3.17542716
48Meningitis (HP:0001287)3.15739055
49Recurrent viral infections (HP:0004429)3.15229808
50Short femoral neck (HP:0100864)3.11795271
51Dysostosis multiplex (HP:0000943)3.11170370
52Spontaneous hematomas (HP:0007420)3.11069669
53Gingivitis (HP:0000230)3.07779507
54Abnormality of the femoral head (HP:0003368)3.06335800
55T lymphocytopenia (HP:0005403)3.06289715
56Increased neuronal autofluorescent lipopigment (HP:0002074)3.02847792
57Recurrent cutaneous fungal infections (HP:0011370)3.02518108
58Chronic mucocutaneous candidiasis (HP:0002728)3.02518108
59Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.01323128
60Absent epiphyses (HP:0010577)3.01323128
61Metaphyseal irregularity (HP:0003025)2.99463920
62Cellulitis (HP:0100658)2.99181294
63Thoracolumbar scoliosis (HP:0002944)2.98208550
64Hypoplasia of the odontoid process (HP:0003311)2.98006025
65Ovoid vertebral bodies (HP:0003300)2.97778026
66Loss of speech (HP:0002371)2.95068777
67Gastrointestinal infarctions (HP:0005244)2.93211857
68Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.91918561
69Exostoses (HP:0100777)2.90430807
70Enlarged epiphyses (HP:0010580)2.89678730
71Platyspondyly (HP:0000926)2.86742901
72Metaphyseal dysplasia (HP:0100255)2.86230530
73Protuberant abdomen (HP:0001538)2.84619866
74Autoimmune thrombocytopenia (HP:0001973)2.84234717
75Coxa vara (HP:0002812)2.82780951
76Abnormal delayed hypersensitivity skin test (HP:0002963)2.80047464
77Abnormality of the proximal phalanges of the hand (HP:0009834)2.79771456
78Urticaria (HP:0001025)2.79273119
79Vasculitis (HP:0002633)2.79084599
80Abnormality of T cell number (HP:0011839)2.77430014
81Beaking of vertebral bodies (HP:0004568)2.75693786
82Spinal cord compression (HP:0002176)2.75241389
83Abnormality of the pubic bones (HP:0003172)2.71563696
84Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.70570816
85Arthropathy (HP:0003040)2.69010327
86Keratoconjunctivitis sicca (HP:0001097)2.68953767
87Increased IgE level (HP:0003212)2.65625813
88Waddling gait (HP:0002515)2.62428009
89Pulmonary infiltrates (HP:0002113)2.61093948
90Disinhibition (HP:0000734)2.60351501
91Encephalitis (HP:0002383)2.59631528
92Abnormality of carpal bone ossification (HP:0006257)2.58053975
93Chest pain (HP:0100749)2.53741042
94Abnormality of the odontoid process (HP:0003310)2.53736008
95Disproportionate short-trunk short stature (HP:0003521)2.51929347
96Lumbar hyperlordosis (HP:0002938)2.50317577
97Abnormal vertebral ossification (HP:0100569)2.47893238
98Osteomyelitis (HP:0002754)2.47145098
99Barrel-shaped chest (HP:0001552)2.46877381
100Hemoptysis (HP:0002105)2.46020891
101Aplasia/hypoplasia of the femur (HP:0005613)2.45271877
102Pustule (HP:0200039)2.44578877
103Limited elbow extension (HP:0001377)2.44031769
104Myocardial infarction (HP:0001658)2.43919916
105Leukocytosis (HP:0001974)2.42354525
106Prolonged bleeding time (HP:0003010)2.41414975
107Keratoconjunctivitis (HP:0001096)2.40126445
108Radial bowing (HP:0002986)2.39955381
109Arterial thrombosis (HP:0004420)2.36191261
110Amyloidosis (HP:0011034)2.35457815
111Epistaxis (HP:0000421)2.34689053
112Systemic lupus erythematosus (HP:0002725)2.32470763
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32398845
114Hepatosplenomegaly (HP:0001433)2.30630049
115Abnormality of the lumbar spine (HP:0100712)2.29150970
116Inflammation of the large intestine (HP:0002037)2.28412942
117Abnormality of polysaccharide metabolism (HP:0011012)2.28113802
118Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28113802
119Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28113802
120Granulocytopenia (HP:0001913)2.27999353
121Petechiae (HP:0000967)2.25944433
122Vertebral clefting (HP:0008428)2.25278820
123Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.24701041
124Limited hip movement (HP:0008800)2.24100972
125Mesomelia (HP:0003027)2.23986160
126Gastrointestinal inflammation (HP:0004386)2.23621103
127Slow saccadic eye movements (HP:0000514)2.21488914
128Abnormality of the phalanges of the 2nd finger (HP:0009541)2.21324997
129Abnormality of T cells (HP:0002843)2.20749964
130Urinary glycosaminoglycan excretion (HP:0003541)2.20312993
131Mucopolysacchariduria (HP:0008155)2.20312993
132Interstitial pulmonary disease (HP:0006530)2.19855160
133Thin ribs (HP:0000883)2.18748204
134Colitis (HP:0002583)2.17806090
135Gingival bleeding (HP:0000225)2.17705427
136Abnormality of the frontal sinuses (HP:0002687)2.15944895
137Increased serum ferritin (HP:0003281)2.15474898
138Upper motor neuron abnormality (HP:0002127)2.14274371
139Neurofibrillary tangles (HP:0002185)2.12645900
140Purpura (HP:0000979)2.10162756
141Abnormal hand bone ossification (HP:0010660)2.09437770
142Autoimmune hemolytic anemia (HP:0001890)2.08872818
143Abnormal ossification of hand bones (HP:0005921)2.07740553
144Relative macrocephaly (HP:0004482)2.07551059
145Broad phalanx (HP:0006009)2.06352405
146Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.05965230
147Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.05785978
148Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.05603675
149Vertebral hypoplasia (HP:0008417)2.05603675
150Viral hepatitis (HP:0006562)2.05583708
151Broad long bones (HP:0005622)2.04406581
152Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.04301625
153Panhypogammaglobulinemia (HP:0003139)2.01894550
154Hematochezia (HP:0002573)2.00769468
155Broad thumb (HP:0011304)1.99529948
156Mixed hearing impairment (HP:0000410)1.98143684
157Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97836463
158Genu valgum (HP:0002857)1.97801189
159Increased IgM level (HP:0003496)1.97468952
160Amaurosis fugax (HP:0100576)1.96768880
161Pulmonary embolism (HP:0002204)1.96198903
162Neuronal loss in central nervous system (HP:0002529)1.96114366
163Hip contracture (HP:0003273)1.95380285
164Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.95166229
165Genu recurvatum (HP:0002816)1.94862128
166Hypoplastic ilia (HP:0000946)1.94357233
167Stillbirth (HP:0003826)1.93954114
168Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93716325
169Fatigue (HP:0012378)1.93129592
170Hydroxyprolinuria (HP:0003080)1.92397506
171Abnormality of proline metabolism (HP:0010907)1.92397506
172Thoracic kyphosis (HP:0002942)1.92117907
173Sepsis (HP:0100806)1.91614125
174Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.90757368
175Micromelia (HP:0002983)1.89477554
176Joint stiffness (HP:0001387)1.89471957
177Abnormality of the acetabulum (HP:0003170)1.89436628
178Agammaglobulinemia (HP:0004432)1.88552435
179Hypergammaglobulinemia (HP:0010702)1.87984989
180Glomerulopathy (HP:0100820)1.87862842
181Anorexia (HP:0002039)1.87600944
182Premature rupture of membranes (HP:0001788)1.87452962
183Episodic fever (HP:0001954)1.87121810
184Spondylolisthesis (HP:0003302)1.86017004
185Abnormality of iron homeostasis (HP:0011031)1.85569956
186Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.85255470
187Mutism (HP:0002300)1.85242282
188Premature loss of primary teeth (HP:0006323)1.85231941
189Segmental peripheral demyelination/remyelination (HP:0003481)1.82993838
190Subacute progressive viral hepatitis (HP:0006572)1.82893068
191Ulnar deviation of the wrist (HP:0003049)1.81080942
192Abnormality of incisor morphology (HP:0011063)1.80073480
193Ulnar bowing (HP:0003031)1.77045377
194Rhizomelia (HP:0008905)1.76084841
195Coxa valga (HP:0002673)1.75692329
196Flared metaphyses (HP:0003015)1.75691453
197Persistence of primary teeth (HP:0006335)1.75657447
198Severe short stature (HP:0003510)1.74288943
199Hand muscle atrophy (HP:0009130)1.72806117
200Short middle phalanx of finger (HP:0005819)1.71756171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.31280471
2MAP3K33.59322696
3PRPF4B3.29983199
4MAP4K13.00581546
5TRIB32.93825337
6BLK2.91246443
7STK242.74310070
8MAP2K32.66258225
9TYK22.63161988
10IRAK42.59695311
11PRKD32.55843289
12RIPK42.43163190
13NTRK32.40649740
14CSK2.36272040
15IRAK32.33838484
16PDGFRA2.21249311
17ZAP702.13733180
18RIPK12.00777360
19MAP3K21.93427781
20ERBB31.92351585
21TAOK11.75735270
22FGFR31.74397631
23MATK1.68771937
24FGR1.64886703
25NTRK11.64491312
26IKBKE1.61550154
27SYK1.60730349
28CAMKK11.57467569
29PRKG21.56388621
30BTK1.55461042
31TXK1.52439960
32SIK11.51857321
33TAOK21.49139175
34MAP3K111.48149257
35TAOK31.41086367
36RET1.40962544
37PLK21.37956111
38MAP3K141.37338444
39MAP3K91.31540790
40PKN21.28148352
41GRK61.28106884
42PRKCH1.27786142
43CAMKK21.23339087
44LYN1.23015962
45NME21.22108309
46TBK11.21919533
47PDGFRB1.18011536
48STK31.17522813
49EPHA41.15596037
50KIT1.14783779
51DMPK1.14484076
52GRK71.13643264
53CSF1R1.13508160
54STK101.13075238
55JAK11.12346730
56SCYL21.10964200
57LCK1.10288962
58MARK31.09892931
59SIK21.09057997
60TNK21.07466263
61JAK31.05608706
62FRK1.01537509
63IRAK21.01107843
64BMX0.99934533
65CDK120.99739830
66STK38L0.99209180
67PTK60.97404613
68TRPM70.95317839
69MAP3K130.94961484
70ITK0.93978528
71IRAK10.93198427
72CHUK0.92595544
73ALK0.89703331
74MAP3K10.87919919
75SMG10.87821897
76KSR20.87676131
77PIM20.86686802
78PAK60.85999690
79PTK20.85252523
80NME10.85072198
81HIPK20.83353231
82SIK30.83096475
83MARK20.81170658
84TEC0.78111987
85IKBKB0.77587292
86KSR10.77011012
87YES10.76004275
88BMPR20.75603824
89TESK20.75573201
90ICK0.74797383
91MAP3K40.74369626
92EPHB10.74246849
93NEK60.73432671
94DAPK20.69689231
95CDC42BPA0.69629532
96ROCK10.69594556
97NEK90.69547441
98MINK10.69242392
99CDK50.68905386
100PAK30.67935762
101GSK3A0.66695222
102MAP3K60.66051300
103SGK30.65921711
104NTRK20.65465652
105CAMK1G0.64223539
106ERN10.63228365
107FES0.62715251
108MAPK70.62134633
109RPS6KL10.62134196
110RPS6KC10.62134196
111PIM10.61741195
112EPHA30.61439826
113LRRK20.60705852
114STK380.58396761
115MAP3K100.58333384
116MOS0.55201193
117PTK2B0.54962118
118CDK40.53645237
119SGK10.53598423
120IGF1R0.52769227
121TGFBR20.52209213
122MAP3K50.52190257
123TTN0.52167584
124CLK10.51910736
125PAK20.51673972
126RPS6KA20.50078883
127MARK10.49752854
128DYRK1A0.49730506
129HCK0.49641573
130FYN0.49008758
131MAPK120.48736023
132RPS6KA60.48663923
133NLK0.48457141
134PDK10.46865877
135MAP3K80.46345411
136RAF10.45879978
137STK110.43727438
138MAP2K70.43698034
139FGFR40.43396863
140PIK3CG0.43218954
141JAK20.43001245
142CDK60.40125680
143MAPKAPK20.39301424
144CAMK1D0.38101810
145PRKCQ0.37559883
146FGFR10.36210317
147FER0.35658124
148PDPK10.35273516
149EGFR0.35124016
150MST40.34833648
151SRC0.34753220
152PRKACG0.34377592
153INSR0.33018069
154MAPK110.33012837
155MAPK130.32393354
156SGK20.32274575
157FLT30.31908321

Predicted pathways (KEGG)

RankGene SetZ-score
1* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.41746512
2ECM-receptor interaction_Homo sapiens_hsa045122.38616100
3Staphylococcus aureus infection_Homo sapiens_hsa051502.20985128
4Acute myeloid leukemia_Homo sapiens_hsa052211.81941867
5NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80521500
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79331761
7Protein digestion and absorption_Homo sapiens_hsa049741.77506760
8Measles_Homo sapiens_hsa051621.65962385
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63533423
10Hematopoietic cell lineage_Homo sapiens_hsa046401.59693662
11Type I diabetes mellitus_Homo sapiens_hsa049401.53704099
12T cell receptor signaling pathway_Homo sapiens_hsa046601.51708502
13Influenza A_Homo sapiens_hsa051641.51588101
14Asthma_Homo sapiens_hsa053101.51335877
15Focal adhesion_Homo sapiens_hsa045101.49727167
16Antigen processing and presentation_Homo sapiens_hsa046121.49029457
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48185174
18Olfactory transduction_Homo sapiens_hsa047401.48122939
19Primary immunodeficiency_Homo sapiens_hsa053401.46503666
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36184911
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.35092185
22Malaria_Homo sapiens_hsa051441.31353100
23Non-small cell lung cancer_Homo sapiens_hsa052231.31205132
24Pertussis_Homo sapiens_hsa051331.30016085
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.28698605
26Cocaine addiction_Homo sapiens_hsa050301.26778418
27Osteoclast differentiation_Homo sapiens_hsa043801.26650071
28Insulin secretion_Homo sapiens_hsa049111.26270389
29Herpes simplex infection_Homo sapiens_hsa051681.25863484
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25780712
31Glioma_Homo sapiens_hsa052141.23594080
32Viral myocarditis_Homo sapiens_hsa054161.22080184
33Type II diabetes mellitus_Homo sapiens_hsa049301.20374093
34Salmonella infection_Homo sapiens_hsa051321.18258164
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18215547
36Circadian entrainment_Homo sapiens_hsa047131.16699266
37Leishmaniasis_Homo sapiens_hsa051401.16179478
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14952534
39Amphetamine addiction_Homo sapiens_hsa050311.13805081
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.12627887
41Salivary secretion_Homo sapiens_hsa049701.11046085
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09838301
43Cholinergic synapse_Homo sapiens_hsa047251.08835743
44TNF signaling pathway_Homo sapiens_hsa046681.08792525
45Shigellosis_Homo sapiens_hsa051311.08439935
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08324214
47African trypanosomiasis_Homo sapiens_hsa051431.07924869
48Hepatitis C_Homo sapiens_hsa051601.07837452
49Apoptosis_Homo sapiens_hsa042101.07790983
50Proteoglycans in cancer_Homo sapiens_hsa052051.06934557
51Long-term potentiation_Homo sapiens_hsa047201.05452945
52Gastric acid secretion_Homo sapiens_hsa049711.03731964
53Allograft rejection_Homo sapiens_hsa053301.01946607
54Chronic myeloid leukemia_Homo sapiens_hsa052201.00643111
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.00522481
56Thyroid hormone synthesis_Homo sapiens_hsa049180.99650665
57Dopaminergic synapse_Homo sapiens_hsa047280.96469648
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.95955707
59Estrogen signaling pathway_Homo sapiens_hsa049150.95160591
60Rheumatoid arthritis_Homo sapiens_hsa053230.94908995
61Morphine addiction_Homo sapiens_hsa050320.94210800
62Chemokine signaling pathway_Homo sapiens_hsa040620.92686353
63Lysosome_Homo sapiens_hsa041420.92461183
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92408043
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92299654
66Gap junction_Homo sapiens_hsa045400.92140283
67Glutamatergic synapse_Homo sapiens_hsa047240.91264638
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90274796
69Renin secretion_Homo sapiens_hsa049240.89890917
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89383894
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89340032
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89036169
73Long-term depression_Homo sapiens_hsa047300.88528932
74Dorso-ventral axis formation_Homo sapiens_hsa043200.88416933
75Oxytocin signaling pathway_Homo sapiens_hsa049210.87609482
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87319135
77Amoebiasis_Homo sapiens_hsa051460.86930073
78Tuberculosis_Homo sapiens_hsa051520.86555526
79Graft-versus-host disease_Homo sapiens_hsa053320.86449254
80GnRH signaling pathway_Homo sapiens_hsa049120.85390527
81GABAergic synapse_Homo sapiens_hsa047270.84986785
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83893996
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83068711
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82937053
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82828215
86Prolactin signaling pathway_Homo sapiens_hsa049170.82800650
87Synaptic vesicle cycle_Homo sapiens_hsa047210.82454766
88Sphingolipid metabolism_Homo sapiens_hsa006000.79515179
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79453834
90Notch signaling pathway_Homo sapiens_hsa043300.79248971
91Dilated cardiomyopathy_Homo sapiens_hsa054140.78779983
92Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78360455
93cAMP signaling pathway_Homo sapiens_hsa040240.77853599
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77634479
95Bladder cancer_Homo sapiens_hsa052190.77245153
96Ovarian steroidogenesis_Homo sapiens_hsa049130.76857332
97Phagosome_Homo sapiens_hsa041450.76487138
98Hepatitis B_Homo sapiens_hsa051610.76446652
99Epstein-Barr virus infection_Homo sapiens_hsa051690.76341617
100Viral carcinogenesis_Homo sapiens_hsa052030.75710501
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75401795
102Toxoplasmosis_Homo sapiens_hsa051450.75360427
103Pancreatic cancer_Homo sapiens_hsa052120.75342182
104MAPK signaling pathway_Homo sapiens_hsa040100.74397099
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73977114
106mTOR signaling pathway_Homo sapiens_hsa041500.73764638
107B cell receptor signaling pathway_Homo sapiens_hsa046620.73395000
108Legionellosis_Homo sapiens_hsa051340.72740813
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72681434
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71785023
111ErbB signaling pathway_Homo sapiens_hsa040120.71369244
112TGF-beta signaling pathway_Homo sapiens_hsa043500.71359486
113Endometrial cancer_Homo sapiens_hsa052130.71336428
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71184903
115Renal cell carcinoma_Homo sapiens_hsa052110.70716180
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70201618
117Platelet activation_Homo sapiens_hsa046110.69193304
118Sulfur metabolism_Homo sapiens_hsa009200.68543883
119Vibrio cholerae infection_Homo sapiens_hsa051100.67573747
120Autoimmune thyroid disease_Homo sapiens_hsa053200.67154535
121Other glycan degradation_Homo sapiens_hsa005110.66982674
122Insulin resistance_Homo sapiens_hsa049310.66809803
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.66701671
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.66378413
125Melanogenesis_Homo sapiens_hsa049160.66165316
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.65974763
127VEGF signaling pathway_Homo sapiens_hsa043700.65772222
128HIF-1 signaling pathway_Homo sapiens_hsa040660.65680582
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65636137
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65617130
131MicroRNAs in cancer_Homo sapiens_hsa052060.65302960
132HTLV-I infection_Homo sapiens_hsa051660.65267488
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64842419
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62307982
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62022087
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61868350
137Endocytosis_Homo sapiens_hsa041440.60064070
138Colorectal cancer_Homo sapiens_hsa052100.59158120
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.58984056
140Prion diseases_Homo sapiens_hsa050200.57895857
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55757799
142Prostate cancer_Homo sapiens_hsa052150.55460058
143FoxO signaling pathway_Homo sapiens_hsa040680.54549570
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51143656
145Inositol phosphate metabolism_Homo sapiens_hsa005620.45744856
146Choline metabolism in cancer_Homo sapiens_hsa052310.44866887
147Small cell lung cancer_Homo sapiens_hsa052220.43091958
148Collecting duct acid secretion_Homo sapiens_hsa049660.40091522

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