CHST10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.84734597
2locomotory exploration behavior (GO:0035641)5.76114238
3synaptic vesicle maturation (GO:0016188)5.46417588
4vocalization behavior (GO:0071625)5.43857569
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.32868247
6synaptic vesicle exocytosis (GO:0016079)5.31455571
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.30707609
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.01765332
9regulation of synaptic vesicle exocytosis (GO:2000300)4.99366445
10regulation of glutamate receptor signaling pathway (GO:1900449)4.96912551
11neuron cell-cell adhesion (GO:0007158)4.88765874
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.83728512
13glutamate secretion (GO:0014047)4.75476444
14protein localization to synapse (GO:0035418)4.66706748
15neurotransmitter secretion (GO:0007269)4.57152453
16synaptic transmission, glutamatergic (GO:0035249)4.57144511
17regulation of synaptic vesicle transport (GO:1902803)4.54821515
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.52683753
19exploration behavior (GO:0035640)4.46356310
20neurotransmitter-gated ion channel clustering (GO:0072578)4.44493490
21gamma-aminobutyric acid transport (GO:0015812)4.40764016
22glutamate receptor signaling pathway (GO:0007215)4.39231585
23neuronal action potential propagation (GO:0019227)4.36202956
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.29283954
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.28963011
26regulation of neuronal synaptic plasticity (GO:0048168)4.24327216
27neuron-neuron synaptic transmission (GO:0007270)4.14090179
28regulation of synapse structural plasticity (GO:0051823)4.12038335
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.08282367
30auditory behavior (GO:0031223)3.94047514
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.92509267
32response to auditory stimulus (GO:0010996)3.92356534
33layer formation in cerebral cortex (GO:0021819)3.91866044
34cellular potassium ion homeostasis (GO:0030007)3.90729801
35transmission of nerve impulse (GO:0019226)3.89723506
36proline transport (GO:0015824)3.86389918
37postsynaptic membrane organization (GO:0001941)3.83232392
38* long-term memory (GO:0007616)3.80309138
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.77919127
40DNA unwinding involved in DNA replication (GO:0006268)3.74740373
41neurotransmitter transport (GO:0006836)3.70823986
42dendritic spine morphogenesis (GO:0060997)3.68609009
43positive regulation of membrane potential (GO:0045838)3.64692745
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60271813
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59166949
46cell migration in hindbrain (GO:0021535)3.57444564
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.57411868
48positive regulation of synapse maturation (GO:0090129)3.56393877
49regulation of neurotransmitter secretion (GO:0046928)3.56344159
50cerebral cortex radially oriented cell migration (GO:0021799)3.54271566
51regulation of vesicle fusion (GO:0031338)3.51537877
52regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.50961992
53regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.49237042
54long-term synaptic potentiation (GO:0060291)3.48064367
55synaptic vesicle endocytosis (GO:0048488)3.45991015
56prepulse inhibition (GO:0060134)3.45245019
57regulation of neurotransmitter levels (GO:0001505)3.44436836
58regulation of postsynaptic membrane potential (GO:0060078)3.43393667
59gamma-aminobutyric acid signaling pathway (GO:0007214)3.40599030
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.39362465
61establishment of mitochondrion localization (GO:0051654)3.39242689
62cerebellar Purkinje cell differentiation (GO:0021702)3.39116285
63regulation of synaptic plasticity (GO:0048167)3.38744563
64response to pheromone (GO:0019236)3.37373386
65regulation of synapse maturation (GO:0090128)3.36198285
66presynaptic membrane assembly (GO:0097105)3.34724821
67positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32765440
68neuron recognition (GO:0008038)3.31282349
69regulation of neurotransmitter transport (GO:0051588)3.31114214
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.30877945
71L-amino acid import (GO:0043092)3.29280003
72sodium ion export (GO:0071436)3.29136742
73cell communication by electrical coupling (GO:0010644)3.27151675
74mechanosensory behavior (GO:0007638)3.26922836
75regulation of respiratory system process (GO:0044065)3.25138421
76positive regulation of dendritic spine morphogenesis (GO:0061003)3.25082647
77pyrimidine nucleobase catabolic process (GO:0006208)3.24300804
78startle response (GO:0001964)3.23462156
79cerebellar granule cell differentiation (GO:0021707)3.23180464
80positive regulation of neurotransmitter secretion (GO:0001956)3.18859478
81dendrite morphogenesis (GO:0048813)3.18681483
82axonal fasciculation (GO:0007413)3.18356490
83neuromuscular synaptic transmission (GO:0007274)3.17104772
84positive regulation of neurotransmitter transport (GO:0051590)3.16922660
85glycine transport (GO:0015816)3.16315592
86regulation of synaptic transmission, GABAergic (GO:0032228)3.13629000
87synapse assembly (GO:0007416)3.12655303
88presynaptic membrane organization (GO:0097090)3.12224389
89neuromuscular process controlling balance (GO:0050885)3.11536624
90* learning (GO:0007612)3.05383233
91membrane hyperpolarization (GO:0060081)3.04661994
92regulation of respiratory gaseous exchange (GO:0043576)3.04021287
93central nervous system projection neuron axonogenesis (GO:0021952)3.03617171
94neuromuscular process controlling posture (GO:0050884)3.02796886
95regulation of dendritic spine morphogenesis (GO:0061001)3.02763049
96positive regulation of synaptic transmission (GO:0050806)3.02109956
97response to histamine (GO:0034776)3.01105926
98alanine transport (GO:0032328)3.01080796
99membrane depolarization (GO:0051899)3.00752496
100membrane depolarization during action potential (GO:0086010)3.00129634
101positive regulation of synapse assembly (GO:0051965)2.99687796
102synaptic transmission (GO:0007268)2.99344251
103neuronal ion channel clustering (GO:0045161)2.99045095
104regulation of synaptic transmission (GO:0050804)2.97341513
105amino acid import (GO:0043090)2.97321913
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95607421
107L-serine metabolic process (GO:0006563)2.91124763
108establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.81498575
109mitochondrion transport along microtubule (GO:0047497)2.81498575
110protein-DNA complex disassembly (GO:0032986)2.65792792
111nucleosome disassembly (GO:0006337)2.65792792
112cerebellar Purkinje cell layer development (GO:0021680)2.59974853
113generation of neurons (GO:0048699)2.52928066
114negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.50132839
115positive regulation of dendritic spine development (GO:0060999)2.48363496
116central nervous system myelination (GO:0022010)2.44433988
117axon ensheathment in central nervous system (GO:0032291)2.44433988
118cerebral cortex neuron differentiation (GO:0021895)2.43572550
119axon extension (GO:0048675)2.43105382
120heterochromatin organization (GO:0070828)2.40615528
121mitotic chromosome condensation (GO:0007076)2.40247055
122nucleobase catabolic process (GO:0046113)2.38033235
123negative regulation of histone methylation (GO:0031061)2.31733957
124DNA strand elongation involved in DNA replication (GO:0006271)2.28779820
125peptidyl-arginine methylation (GO:0018216)2.25833213
126peptidyl-arginine N-methylation (GO:0035246)2.25833213
127RNA localization (GO:0006403)2.25552979
128neuron projection extension (GO:1990138)2.24173520
129innervation (GO:0060384)2.23645826
130DNA strand elongation (GO:0022616)2.21554339
131positive regulation of mitochondrial fission (GO:0090141)2.20231049
132protein localization to chromosome, centromeric region (GO:0071459)2.19902908
133potassium ion homeostasis (GO:0055075)2.19437538
134sister chromatid segregation (GO:0000819)2.18239740
135camera-type eye morphogenesis (GO:0048593)2.18183683
136histone arginine methylation (GO:0034969)2.18129232
137mitotic sister chromatid segregation (GO:0000070)2.17885051
138DNA topological change (GO:0006265)2.17599938
139apical protein localization (GO:0045176)2.17452230
140convergent extension (GO:0060026)2.17366377
141chromatin remodeling at centromere (GO:0031055)2.15745304
142intraspecies interaction between organisms (GO:0051703)2.15542723
143social behavior (GO:0035176)2.15542723
144negative regulation of microtubule polymerization (GO:0031115)2.14703860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.56546253
2E2F7_22180533_ChIP-Seq_HELA_Human4.22048733
3GBX2_23144817_ChIP-Seq_PC3_Human3.82138064
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10209193
5REST_21632747_ChIP-Seq_MESCs_Mouse3.09857477
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01644905
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.94768855
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94138592
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.87996427
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73001499
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60541413
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58588595
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58013586
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53108048
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53108048
16DROSHA_22980978_ChIP-Seq_HELA_Human2.52196249
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.51065422
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50728501
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.50177819
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.49712522
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35062451
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31929776
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.31310505
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.31247348
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.28102459
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27416840
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26589494
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.20777372
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.20436827
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14206661
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05770610
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05717822
33AR_21572438_ChIP-Seq_LNCaP_Human1.97783076
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.90333903
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84759613
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83836328
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82818524
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82286783
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81891636
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79534282
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79513083
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73986251
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69494432
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68501089
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.63010093
46SMAD4_21799915_ChIP-Seq_A2780_Human1.62958588
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60293270
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56271862
49TAF15_26573619_Chip-Seq_HEK293_Human1.54853343
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53598846
51P300_19829295_ChIP-Seq_ESCs_Human1.51149117
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.48217435
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.45980706
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45289440
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43486824
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.41984308
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41249452
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40425676
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39618076
60RNF2_27304074_Chip-Seq_NSC_Mouse1.37165059
61OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.36788921
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35633400
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34863113
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33817289
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30620133
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29566165
67XRN2_22483619_ChIP-Seq_HELA_Human1.29211668
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28951416
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28167130
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27854668
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27088745
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25127541
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23917845
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23774871
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.23372917
76RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.23212868
77AR_25329375_ChIP-Seq_VCAP_Human1.22807612
78* RING1B_27294783_Chip-Seq_ESCs_Mouse1.22706910
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.22230259
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21033009
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.20844329
82ZNF274_21170338_ChIP-Seq_K562_Hela1.20726775
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19877946
84STAT3_23295773_ChIP-Seq_U87_Human1.18046633
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.17993024
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17046629
87TCF4_23295773_ChIP-Seq_U87_Human1.16324046
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.14913093
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14393447
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14351543
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14234490
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14097837
93AR_19668381_ChIP-Seq_PC3_Human1.12978828
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12709525
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.11787635
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.10966916
97KDM2B_26808549_Chip-Seq_K562_Human1.10957119
98* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10735618
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10276520
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09658080
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09482876
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08729514
103* NANOG_18555785_Chip-Seq_ESCs_Mouse1.08605446
104IGF1R_20145208_ChIP-Seq_DFB_Human1.08407291
105POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08325155
106RUNX2_22187159_ChIP-Seq_PCA_Human1.08275970
107SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08184740
108MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08037097
109FUS_26573619_Chip-Seq_HEK293_Human1.06618010
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06616150
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05980045
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05980045
113MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04160459
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03255935
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02942026
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01459008
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01334119
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01150201
119YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00893041
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00768551
121* E2F1_18555785_Chip-Seq_ESCs_Mouse1.00759451
122CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00385772
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00161818
124SOX3_22085726_ChIP-Seq_NPCs_Mouse0.99542296
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.98336199
126YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98287893
127* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97903978
128TTF2_22483619_ChIP-Seq_HELA_Human0.97071548
129RING1B_27294783_Chip-Seq_NPCs_Mouse0.96492632
130CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96232857
131SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96054150
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.95628847
133MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95128678
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94681610
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.94307691
136POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93828196
137RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93827150
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93701496
139JUN_21703547_ChIP-Seq_K562_Human0.92280074
140* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91899146
141* FLI1_27457419_Chip-Seq_LIVER_Mouse0.91674093
142SALL1_21062744_ChIP-ChIP_HESCs_Human0.91265848
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.90967147
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90082016
145SOX9_26525672_Chip-Seq_HEART_Mouse0.89574660
146* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89507700
147* CMYC_18555785_Chip-Seq_ESCs_Mouse0.88958206
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88607067
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88061070
150BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87943840
151ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87912426
152* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87658950
153ER_23166858_ChIP-Seq_MCF-7_Human0.86837662
154* P53_22387025_ChIP-Seq_ESCs_Mouse0.85819694
155* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83900522
156GATA1_26923725_Chip-Seq_HPCs_Mouse0.83425548
157SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82518902

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.75793380
2MP0003880_abnormal_central_pattern4.12745788
3* MP0003635_abnormal_synaptic_transmissio3.90918199
4MP0005423_abnormal_somatic_nervous3.48467236
5MP0009745_abnormal_behavioral_response3.33362982
6MP0009046_muscle_twitch3.25466933
7MP0004270_analgesia3.14506801
8* MP0002063_abnormal_learning/memory/cond3.13192933
9MP0002064_seizures2.97453273
10MP0001968_abnormal_touch/_nociception2.83800935
11MP0002572_abnormal_emotion/affect_behav2.79847360
12MP0002822_catalepsy2.78308574
13MP0001486_abnormal_startle_reflex2.68856671
14MP0002734_abnormal_mechanical_nocicepti2.52619179
15MP0002272_abnormal_nervous_system2.44191651
16MP0002736_abnormal_nociception_after2.25794931
17MP0003787_abnormal_imprinting2.19458187
18MP0001440_abnormal_grooming_behavior2.17599633
19MP0002735_abnormal_chemical_nociception2.13823776
20MP0005646_abnormal_pituitary_gland2.11639242
21MP0005645_abnormal_hypothalamus_physiol2.04758735
22MP0001501_abnormal_sleep_pattern2.00785775
23MP0002557_abnormal_social/conspecific_i1.97540372
24MP0002067_abnormal_sensory_capabilities1.97311781
25MP0008569_lethality_at_weaning1.97306025
26MP0001188_hyperpigmentation1.95064009
27MP0002733_abnormal_thermal_nociception1.94105534
28MP0001970_abnormal_pain_threshold1.91209875
29MP0004924_abnormal_behavior1.88565871
30MP0005386_behavior/neurological_phenoty1.88565871
31MP0002184_abnormal_innervation1.88151533
32MP0001529_abnormal_vocalization1.85621324
33MP0000778_abnormal_nervous_system1.83055913
34MP0002638_abnormal_pupillary_reflex1.82098404
35MP0006276_abnormal_autonomic_nervous1.79610053
36MP0001984_abnormal_olfaction1.67602262
37MP0001502_abnormal_circadian_rhythm1.66220562
38MP0004858_abnormal_nervous_system1.63682844
39MP0004811_abnormal_neuron_physiology1.62352021
40MP0000049_abnormal_middle_ear1.57707917
41MP0010030_abnormal_orbit_morphology1.57056410
42MP0001905_abnormal_dopamine_level1.55486318
43MP0004142_abnormal_muscle_tone1.52624653
44MP0006292_abnormal_olfactory_placode1.51506162
45MP0002249_abnormal_larynx_morphology1.49563956
46MP0000955_abnormal_spinal_cord1.48713038
47MP0003111_abnormal_nucleus_morphology1.48506715
48MP0004885_abnormal_endolymph1.47017289
49MP0000537_abnormal_urethra_morphology1.45702766
50MP0003122_maternal_imprinting1.40102384
51MP0002882_abnormal_neuron_morphology1.39962940
52MP0002909_abnormal_adrenal_gland1.37661370
53MP0002066_abnormal_motor_capabilities/c1.34641995
54MP0003942_abnormal_urinary_system1.32904556
55MP0003890_abnormal_embryonic-extraembry1.32394993
56MP0001293_anophthalmia1.31243143
57MP0002653_abnormal_ependyma_morphology1.26672481
58MP0009780_abnormal_chondrocyte_physiolo1.26343623
59MP0003938_abnormal_ear_development1.24880334
60MP0000569_abnormal_digit_pigmentation1.21794075
61MP0003329_amyloid_beta_deposits1.19721590
62MP0002697_abnormal_eye_size1.18995685
63MP0008932_abnormal_embryonic_tissue1.18955550
64MP0003879_abnormal_hair_cell1.17916108
65MP0002152_abnormal_brain_morphology1.17345275
66MP0005499_abnormal_olfactory_system1.16625944
67MP0005394_taste/olfaction_phenotype1.16625944
68MP0003633_abnormal_nervous_system1.13406936
69MP0008877_abnormal_DNA_methylation1.13243612
70MP0000534_abnormal_ureter_morphology1.11556538
71MP0004742_abnormal_vestibular_system1.11330336
72MP0002234_abnormal_pharynx_morphology1.10005970
73MP0002233_abnormal_nose_morphology1.09935161
74MP0000631_abnormal_neuroendocrine_gland1.09779991
75MP0001299_abnormal_eye_distance/1.08776185
76MP0010094_abnormal_chromosome_stability1.08759683
77MP0003937_abnormal_limbs/digits/tail_de1.08734327
78MP0000428_abnormal_craniofacial_morphol1.08238596
79MP0009053_abnormal_anal_canal1.06678050
80MP0003631_nervous_system_phenotype1.05220964
81MP0003119_abnormal_digestive_system1.04226558
82MP0003693_abnormal_embryo_hatching1.04104905
83MP0003385_abnormal_body_wall1.03370387
84MP0001346_abnormal_lacrimal_gland1.02460946
85MP0003077_abnormal_cell_cycle1.02158461
86MP0009672_abnormal_birth_weight1.01303205
87MP0005248_abnormal_Harderian_gland1.00996888
88MP0002938_white_spotting0.98976179
89MP0005171_absent_coat_pigmentation0.98649704
90MP0005551_abnormal_eye_electrophysiolog0.97550041
91MP0001963_abnormal_hearing_physiology0.92173090
92MP0003755_abnormal_palate_morphology0.91622637
93MP0008872_abnormal_physiological_respon0.91562862
94MP0005187_abnormal_penis_morphology0.91318374
95MP0001986_abnormal_taste_sensitivity0.91131597
96MP0009379_abnormal_foot_pigmentation0.90855562
97MP0001286_abnormal_eye_development0.90406027
98MP0002081_perinatal_lethality0.90213132
99MP0002069_abnormal_eating/drinking_beha0.90082503
100MP0002229_neurodegeneration0.88751982
101MP0005623_abnormal_meninges_morphology0.88695145
102MP0002116_abnormal_craniofacial_bone0.88352456
103MP0001485_abnormal_pinna_reflex0.88025176
104MP0004133_heterotaxia0.87484063
105MP0002092_abnormal_eye_morphology0.85985203
106MP0003121_genomic_imprinting0.85150096
107MP0002085_abnormal_embryonic_tissue0.84562236
108MP0001730_embryonic_growth_arrest0.84237041
109MP0002752_abnormal_somatic_nervous0.83936515
110MP0003690_abnormal_glial_cell0.83627006
111MP0005409_darkened_coat_color0.83506924
112MP0001177_atelectasis0.82591889
113MP0003935_abnormal_craniofacial_develop0.81499323
114MP0003632_abnormal_nervous_system0.81065175
115MP0008058_abnormal_DNA_repair0.78282530
116MP0002084_abnormal_developmental_patter0.78236833
117MP0003705_abnormal_hypodermis_morpholog0.77490167
118MP0006072_abnormal_retinal_apoptosis0.76370894
119MP0010386_abnormal_urinary_bladder0.75870164
120MP0003137_abnormal_impulse_conducting0.75667178
121MP0003634_abnormal_glial_cell0.74055728
122MP0005253_abnormal_eye_physiology0.70740091
123MP0002163_abnormal_gland_morphology0.68095447
124MP0003861_abnormal_nervous_system0.68012422
125MP0000026_abnormal_inner_ear0.65177620
126MP0000015_abnormal_ear_pigmentation0.64214718
127MP0003136_yellow_coat_color0.64143676
128MP0003183_abnormal_peptide_metabolism0.63991250
129MP0003123_paternal_imprinting0.60733725
130MP0002751_abnormal_autonomic_nervous0.60127474
131MP0000566_synostosis0.59101210
132MP0004085_abnormal_heartbeat0.57269332
133MP0010769_abnormal_survival0.57055353
134MP0001943_abnormal_respiration0.56251483
135MP0000751_myopathy0.56241049
136MP0008789_abnormal_olfactory_epithelium0.56161834
137MP0002082_postnatal_lethality0.55455586
138MP0010770_preweaning_lethality0.55455586
139MP0010768_mortality/aging0.55115811
140MP0005379_endocrine/exocrine_gland_phen0.53794714
141MP0008874_decreased_physiological_sensi0.52672767
142MP0002090_abnormal_vision0.51166353
143MP0005535_abnormal_body_temperature0.50635961

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.13758540
2Myokymia (HP:0002411)6.10983482
3Focal seizures (HP:0007359)5.17356721
4Epileptic encephalopathy (HP:0200134)4.78221949
5Febrile seizures (HP:0002373)4.72416045
6Visual hallucinations (HP:0002367)4.44974920
7Progressive cerebellar ataxia (HP:0002073)4.38966735
8Atonic seizures (HP:0010819)3.84582245
9Broad-based gait (HP:0002136)3.59004532
10Action tremor (HP:0002345)3.55417014
11Absence seizures (HP:0002121)3.47561301
12Generalized tonic-clonic seizures (HP:0002069)3.33339279
13Dialeptic seizures (HP:0011146)3.33186044
14Ankle clonus (HP:0011448)3.13390383
15Gaze-evoked nystagmus (HP:0000640)3.06642303
16Septo-optic dysplasia (HP:0100842)3.00475895
17Poor eye contact (HP:0000817)3.00357363
18Diplopia (HP:0000651)2.99174230
19Abnormality of binocular vision (HP:0011514)2.99174230
20Depression (HP:0000716)2.89388318
21Abnormal eating behavior (HP:0100738)2.87591215
22Dysdiadochokinesis (HP:0002075)2.86587606
23Hemiparesis (HP:0001269)2.85622187
24Truncal ataxia (HP:0002078)2.85090828
25Morphological abnormality of the inner ear (HP:0011390)2.83235603
26Limb dystonia (HP:0002451)2.81967423
27Anxiety (HP:0000739)2.76230947
28Impaired vibration sensation in the lower limbs (HP:0002166)2.75644629
29Megalencephaly (HP:0001355)2.75252993
30Abnormal hair whorl (HP:0010721)2.71486976
31Supranuclear gaze palsy (HP:0000605)2.68842535
32Mutism (HP:0002300)2.68626077
33Hyperacusis (HP:0010780)2.64085673
34Cortical dysplasia (HP:0002539)2.62188287
35Fetal akinesia sequence (HP:0001989)2.59884838
36Impaired smooth pursuit (HP:0007772)2.59479823
37Overriding aorta (HP:0002623)2.57868682
38Postural instability (HP:0002172)2.54509780
39Hyperventilation (HP:0002883)2.54130156
40Bradykinesia (HP:0002067)2.51656918
41Hepatoblastoma (HP:0002884)2.49841435
42Urinary bladder sphincter dysfunction (HP:0002839)2.48462817
43Polyphagia (HP:0002591)2.47696442
44Aplasia involving bones of the upper limbs (HP:0009823)2.46500271
45Aplasia of the phalanges of the hand (HP:0009802)2.46500271
46Aplasia involving bones of the extremities (HP:0009825)2.46500271
47Abnormality of ocular smooth pursuit (HP:0000617)2.45302136
48Increased nuchal translucency (HP:0010880)2.45195878
49Hemiplegia (HP:0002301)2.44517648
50Genetic anticipation (HP:0003743)2.44473286
51Dysmetria (HP:0001310)2.44440637
52Abnormality of cochlea (HP:0000375)2.43373697
53Abnormal social behavior (HP:0012433)2.42778385
54Impaired social interactions (HP:0000735)2.42778385
55Partial duplication of thumb phalanx (HP:0009944)2.38463013
56Excessive salivation (HP:0003781)2.37794131
57Drooling (HP:0002307)2.37794131
58Elfin facies (HP:0004428)2.36944490
59Turricephaly (HP:0000262)2.34311712
60Papilledema (HP:0001085)2.32492606
61Stereotypic behavior (HP:0000733)2.28840762
62Progressive inability to walk (HP:0002505)2.27571242
63Abnormality of the diencephalon (HP:0010662)2.26578997
64Amyotrophic lateral sclerosis (HP:0007354)2.26327331
65Urinary urgency (HP:0000012)2.25441136
66Renovascular hypertension (HP:0100817)2.23938425
67Epileptiform EEG discharges (HP:0011182)2.23377797
68Amblyopia (HP:0000646)2.21529955
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.19675355
70EEG with generalized epileptiform discharges (HP:0011198)2.17332339
71Gait imbalance (HP:0002141)2.15678845
72Abnormality of the lower motor neuron (HP:0002366)2.11956329
73Spastic gait (HP:0002064)2.10946626
74Peripheral hypomyelination (HP:0007182)2.10324544
75Hypsarrhythmia (HP:0002521)2.10188141
76Absent septum pellucidum (HP:0001331)2.05357407
77Obstructive sleep apnea (HP:0002870)2.05182628
78Scanning speech (HP:0002168)2.04928204
79Partial duplication of the phalanx of hand (HP:0009999)2.03572953
80Sleep apnea (HP:0010535)2.01687748
81High anterior hairline (HP:0009890)1.93937327
82Cerebral hypomyelination (HP:0006808)1.93429279
83Inability to walk (HP:0002540)1.91281983
84Abnormality of the labia minora (HP:0012880)1.90001999
85Cutaneous finger syndactyly (HP:0010554)1.89676459
86Trigonocephaly (HP:0000243)1.89500529
87Cutaneous syndactyly (HP:0012725)1.88993272
88Impaired vibratory sensation (HP:0002495)1.88252432
89Renal duplication (HP:0000075)1.88056909
90Abnormality of the septum pellucidum (HP:0007375)1.86365712
91Shallow orbits (HP:0000586)1.84480255
92Pointed chin (HP:0000307)1.84034890
93Failure to thrive in infancy (HP:0001531)1.83876315
94Agitation (HP:0000713)1.83482614
95Specific learning disability (HP:0001328)1.83338011
96Narrow nasal bridge (HP:0000446)1.83243023
97Incomplete penetrance (HP:0003829)1.83131440
98Megalocornea (HP:0000485)1.83080605
99Optic nerve hypoplasia (HP:0000609)1.82766757
100Lower limb muscle weakness (HP:0007340)1.81112469
101Focal dystonia (HP:0004373)1.80922836
102Protruding tongue (HP:0010808)1.79945426
103Pheochromocytoma (HP:0002666)1.79867583
104Hyperthyroidism (HP:0000836)1.78649988
105Status epilepticus (HP:0002133)1.78486627
106Flat cornea (HP:0007720)1.77266146
107Bowel diverticulosis (HP:0005222)1.76221394
108Torticollis (HP:0000473)1.75926987
109Menstrual irregularities (HP:0000858)1.75505762
110Intention tremor (HP:0002080)1.75403599
111Spinal canal stenosis (HP:0003416)1.74993441
112Duplication of thumb phalanx (HP:0009942)1.73763582
113Abnormality of salivation (HP:0100755)1.73674108
114Broad distal phalanx of finger (HP:0009836)1.73078116
115Diastasis recti (HP:0001540)1.73034233
116Generalized hypotonia (HP:0001290)1.72215493
117Patellar dislocation (HP:0002999)1.71806812
118Delusions (HP:0000746)1.71719531
119Split foot (HP:0001839)1.71343215
120Congenital primary aphakia (HP:0007707)1.70571383
121Hypoplasia of the brainstem (HP:0002365)1.70536925
122Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70536925
123Poor suck (HP:0002033)1.69952073
124Obsessive-compulsive behavior (HP:0000722)1.69813139
125Truncus arteriosus (HP:0001660)1.69712699
126Abnormality of the 4th metacarpal (HP:0010012)1.68929169
127Arnold-Chiari malformation (HP:0002308)1.68468339
128Gastroesophageal reflux (HP:0002020)1.67971227
129Unsteady gait (HP:0002317)1.67896605
130Medial flaring of the eyebrow (HP:0010747)1.65405974
131Absent speech (HP:0001344)1.65009318
132Nephrogenic diabetes insipidus (HP:0009806)1.64816487
133Abnormality of the phalanges of the hallux (HP:0010057)1.64642906
134Broad thumb (HP:0011304)1.64062393
135Maternal diabetes (HP:0009800)1.64037298
136Gait ataxia (HP:0002066)1.63625733
137Lissencephaly (HP:0001339)1.63344668
138Insomnia (HP:0100785)1.62761676
139Neuroendocrine neoplasm (HP:0100634)1.62675672
140Blue irides (HP:0000635)1.62146381
141Limb ataxia (HP:0002070)1.61179177
142Autism (HP:0000717)1.59592066
143Broad finger (HP:0001500)1.59433338
144Akinesia (HP:0002304)1.59319760
145Abnormal EKG (HP:0003115)1.59112496
146Annular pancreas (HP:0001734)1.58666736
147Retinal dysplasia (HP:0007973)1.58441990
148Broad phalanges of the hand (HP:0009768)1.58347651
149Urethral obstruction (HP:0000796)1.58311426
150Rectovaginal fistula (HP:0000143)1.56755654
151Rectal fistula (HP:0100590)1.56755654
152Colon cancer (HP:0003003)1.56268623
153Hypoplasia of the corpus callosum (HP:0002079)1.56240296
154Absent epiphyses (HP:0010577)1.54598929
155Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.54598929
156Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.53120364
157Short 4th metacarpal (HP:0010044)1.53120364
158Bowel incontinence (HP:0002607)1.52776979
159Abnormal lung lobation (HP:0002101)1.52459963
160Coronal craniosynostosis (HP:0004440)1.52341768
161Hammertoe (HP:0001765)1.51254316
162Choanal stenosis (HP:0000452)1.51250174
163Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.50439664
164Vertebral arch anomaly (HP:0008438)1.49430042
165Missing ribs (HP:0000921)1.48752311
166Abnormality of the antihelix (HP:0009738)1.48094647
167Broad phalanx (HP:0006009)1.47968768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.79465796
2NTRK34.15276095
3EPHA43.75110034
4MAP2K72.95871894
5MAP3K92.90909092
6TNIK2.83229080
7NTRK22.79992034
8MAP3K42.75909879
9CDC72.68989983
10MINK12.51280827
11CASK2.26587297
12MAP3K122.09044745
13PRPF4B2.07944147
14MAPK132.04437367
15DAPK22.00848610
16SGK21.57371739
17PRKD31.54683127
18RIPK41.47886112
19PHKG21.45432010
20PHKG11.45432010
21KSR11.42811279
22PLK41.40651473
23AKT31.39238502
24PLK21.38217357
25CDK191.37805916
26DAPK11.36728689
27CDK51.35017377
28CAMKK11.34658934
29MAP2K41.31919898
30BUB11.30121980
31PAK61.29867246
32MAP3K101.28542759
33SGK2231.27234367
34SGK4941.27234367
35ARAF1.25488418
36PRKCG1.25094760
37SIK21.24525412
38ICK1.24373323
39SRPK11.20503862
40GRK51.17417974
41LMTK21.16497431
42CSNK1G31.15642683
43PINK11.14478212
44SIK31.10897743
45SGK31.10645601
46FES1.10040629
47EEF2K1.08066033
48UHMK11.07327507
49AURKA1.07261988
50NEK11.05484402
51STK381.04431779
52PKN11.03539484
53CSNK1A1L1.03181215
54PNCK1.02588108
55TTK1.02427187
56EPHB21.00896941
57NTRK10.97591980
58CSNK1G10.97121178
59KSR20.96939045
60IRAK30.96468697
61SMG10.94862858
62CAMKK20.93500925
63FGFR20.92347347
64MAP3K130.89981452
65TNK20.87659993
66DYRK1A0.86925972
67BRAF0.86638988
68BMPR20.86080139
69IRAK20.84835378
70NEK20.84798048
71CAMK1G0.84620185
72PRKCH0.79836261
73MAP3K110.78854620
74CCNB10.78845126
75CDK180.78670815
76CDC42BPA0.77936654
77TYRO30.77245439
78MKNK10.77015793
79ATR0.76884671
80NEK60.76775653
81CAMK2A0.75394940
82BRSK10.74440061
83PBK0.74044937
84CDK150.73575525
85PLK10.73476753
86PDGFRA0.72665425
87CDK20.72342397
88VRK20.71198867
89DYRK1B0.69374412
90CSNK1E0.68953183
91STK160.68780239
92CAMK2B0.68381562
93ERBB30.68185208
94CDK11A0.67398686
95CAMK10.67396332
96AKT20.66013973
97SGK10.65806558
98CDK10.65309967
99CHEK20.63492760
100ALK0.62483538
101CDK140.61885769
102TAF10.60529047
103CSNK1G20.60367865
104PRKDC0.59484125
105MKNK20.58807558
106GSK3B0.58795031
107ATM0.58002383
108DMPK0.57994956
109MTOR0.57747548
110MARK20.57354511
111CHEK10.57197806
112STK110.56305101
113PAK20.56181208
114BCKDK0.55972062
115CAMK40.53066867
116LATS20.52593633
117PRKCE0.52177486
118RAF10.52025693
119NME10.51953434
120MAP3K20.50969742
121AURKB0.48876287
122DYRK20.48585548
123MAPK140.48226336
124ADRBK20.47645874
125CDK70.46218113
126PRKCZ0.44835548
127ROCK20.44798488
128MAPK90.44743865
129MUSK0.41559073
130WNK30.39506289
131PLK30.39209586
132GRK70.38864675
133RPS6KA30.38500318
134CDK30.38129227
135CAMK2G0.36858933
136ZAK0.36394949
137PRKCB0.36207557
138IRAK40.35909819
139MAPK120.35280735
140MAPK70.34367678
141MAPK100.33655649
142MAPK80.31560083
143FYN0.31422071
144PRKD20.31396671
145RPS6KB10.30232863
146TAOK10.30074572
147TXK0.29695438
148YES10.29469781

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.31180911
2Synaptic vesicle cycle_Homo sapiens_hsa047213.34181149
3GABAergic synapse_Homo sapiens_hsa047272.88476256
4Olfactory transduction_Homo sapiens_hsa047402.84632960
5Morphine addiction_Homo sapiens_hsa050322.74707655
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74086388
7Glutamatergic synapse_Homo sapiens_hsa047242.73971661
8Circadian entrainment_Homo sapiens_hsa047132.72401175
9Long-term potentiation_Homo sapiens_hsa047202.62003844
10Amphetamine addiction_Homo sapiens_hsa050312.41490148
11DNA replication_Homo sapiens_hsa030302.29362352
12Dopaminergic synapse_Homo sapiens_hsa047282.11302721
13Insulin secretion_Homo sapiens_hsa049112.03112283
14Salivary secretion_Homo sapiens_hsa049702.02908465
15Taste transduction_Homo sapiens_hsa047422.02824018
16Cholinergic synapse_Homo sapiens_hsa047251.95071655
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81838811
18Cocaine addiction_Homo sapiens_hsa050301.79952314
19Serotonergic synapse_Homo sapiens_hsa047261.78335934
20Gastric acid secretion_Homo sapiens_hsa049711.75665516
21Long-term depression_Homo sapiens_hsa047301.72824776
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62461020
23Base excision repair_Homo sapiens_hsa034101.60067614
24Calcium signaling pathway_Homo sapiens_hsa040201.59699867
25Spliceosome_Homo sapiens_hsa030401.55890591
26Cell cycle_Homo sapiens_hsa041101.55254021
27Renin secretion_Homo sapiens_hsa049241.45395967
28Mismatch repair_Homo sapiens_hsa034301.44717426
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44656723
30Oxytocin signaling pathway_Homo sapiens_hsa049211.44359131
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42353533
32Vitamin B6 metabolism_Homo sapiens_hsa007501.41363789
33Collecting duct acid secretion_Homo sapiens_hsa049661.40086230
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36820530
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31192773
36Hippo signaling pathway_Homo sapiens_hsa043901.29655053
37GnRH signaling pathway_Homo sapiens_hsa049121.28970186
38cAMP signaling pathway_Homo sapiens_hsa040241.23679738
39Gap junction_Homo sapiens_hsa045401.21301750
40Steroid biosynthesis_Homo sapiens_hsa001001.20526822
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20223876
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18992485
43Biosynthesis of amino acids_Homo sapiens_hsa012301.18177975
44Sulfur relay system_Homo sapiens_hsa041221.16302145
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15044387
46Basal cell carcinoma_Homo sapiens_hsa052171.12888348
47Ribosome_Homo sapiens_hsa030101.09876691
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07703199
49Axon guidance_Homo sapiens_hsa043601.06585878
50Melanogenesis_Homo sapiens_hsa049161.02992120
51Cardiac muscle contraction_Homo sapiens_hsa042601.02970901
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02600553
53RNA transport_Homo sapiens_hsa030131.01787609
54Oocyte meiosis_Homo sapiens_hsa041141.01668953
55Phototransduction_Homo sapiens_hsa047441.00704050
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97484573
57RNA polymerase_Homo sapiens_hsa030200.96450512
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96408075
59Lysine degradation_Homo sapiens_hsa003100.95493356
60Fanconi anemia pathway_Homo sapiens_hsa034600.95152707
61Type I diabetes mellitus_Homo sapiens_hsa049400.93918125
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93609725
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93445343
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92516556
65Type II diabetes mellitus_Homo sapiens_hsa049300.92414519
66Estrogen signaling pathway_Homo sapiens_hsa049150.92097574
67ErbB signaling pathway_Homo sapiens_hsa040120.90447137
68Glioma_Homo sapiens_hsa052140.88663948
69Notch signaling pathway_Homo sapiens_hsa043300.86097574
70Homologous recombination_Homo sapiens_hsa034400.83365449
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82738581
72Alcoholism_Homo sapiens_hsa050340.82559816
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81618315
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81447476
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.79896743
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79078420
77Vibrio cholerae infection_Homo sapiens_hsa051100.78888629
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78140969
79MicroRNAs in cancer_Homo sapiens_hsa052060.76857816
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76759603
81Nucleotide excision repair_Homo sapiens_hsa034200.75166403
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.73916609
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73293152
84Circadian rhythm_Homo sapiens_hsa047100.72869794
85MAPK signaling pathway_Homo sapiens_hsa040100.70177510
86Arginine and proline metabolism_Homo sapiens_hsa003300.70035576
87Choline metabolism in cancer_Homo sapiens_hsa052310.69794271
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67986351
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.67724076
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67051159
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.66976219
92Basal transcription factors_Homo sapiens_hsa030220.66853072
93Pancreatic secretion_Homo sapiens_hsa049720.66608885
94Adherens junction_Homo sapiens_hsa045200.65686105
95Dorso-ventral axis formation_Homo sapiens_hsa043200.62664912
96Pyrimidine metabolism_Homo sapiens_hsa002400.61781880
97Prion diseases_Homo sapiens_hsa050200.61640698
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59931521
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59460578
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.59184570
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57822828
102Thyroid hormone synthesis_Homo sapiens_hsa049180.57525360
103Alzheimers disease_Homo sapiens_hsa050100.57078724
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55788362
105Wnt signaling pathway_Homo sapiens_hsa043100.55302172
106Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53302345
107Melanoma_Homo sapiens_hsa052180.52673943
108Parkinsons disease_Homo sapiens_hsa050120.52584546
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52271619
110Endometrial cancer_Homo sapiens_hsa052130.51828415
111Ras signaling pathway_Homo sapiens_hsa040140.50642730
112* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50054714
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.49284289
114Oxidative phosphorylation_Homo sapiens_hsa001900.48964848
115Chronic myeloid leukemia_Homo sapiens_hsa052200.48955520
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46845564
117Chemokine signaling pathway_Homo sapiens_hsa040620.46454405
118Huntingtons disease_Homo sapiens_hsa050160.46164133
119Colorectal cancer_Homo sapiens_hsa052100.45973176
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44409768
121Dilated cardiomyopathy_Homo sapiens_hsa054140.44051015
122Rap1 signaling pathway_Homo sapiens_hsa040150.42681987
123Inositol phosphate metabolism_Homo sapiens_hsa005620.42134397
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40565449
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39857143
126African trypanosomiasis_Homo sapiens_hsa051430.38830288
127T cell receptor signaling pathway_Homo sapiens_hsa046600.38297360
128Non-small cell lung cancer_Homo sapiens_hsa052230.38246990
129Endocytosis_Homo sapiens_hsa041440.34120107
130Fatty acid biosynthesis_Homo sapiens_hsa000610.33780785
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32887531
132Glucagon signaling pathway_Homo sapiens_hsa049220.31406574
133mRNA surveillance pathway_Homo sapiens_hsa030150.31375377
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30428437
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30023786
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29054749
137Rheumatoid arthritis_Homo sapiens_hsa053230.28370696
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27338699
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26546315
140VEGF signaling pathway_Homo sapiens_hsa043700.25601453
141Hedgehog signaling pathway_Homo sapiens_hsa043400.23638672

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